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You searched for subject:(Propylparaben). Showing records 1 – 3 of 3 total matches.

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Uppsala University

1. Pohl, Johannes. Thyroid Endocrine Disruption of Propylparaben Assessed Using an Optimized Individual Xenopus tropicalis Metamorphosing Tadpole Exposure System.

Degree: Biology Education Centre, 2015, Uppsala University

The anuran Xenopus tropicalis tadpole is an attractive model animal in toxicological evaluation of suspected thyroid disrupting xenobiotics. Due to its reliance of a functioning hypothalamic-pituitary-thyroid (HPT) axis for normal metamorphosis, effects on the HPT axis produces apical endpoints, which are easy to measure. More sensitive endpoints of mRNA expression and histological evaluation of the thyroid gland itself provide strong indications of in vivo thyroid endocrine disruption. X. tropicalis is traditionally exposed in groups of 20 animals in four replicates for each treatment group. However, exposing tadpoles individually can provide stronger statistics and a reduction of total animal sacrifice. In this study we have developed and optimized an individual exposure system by a method development study. This method was then applied in an exposure experiment of a suspected thyroid endocrine disruptor, propylparaben (PrP). Prometamorphotic (NF stage 51) X. tropicalis tadpoles were distributed in three treatment groups (0.05, 0.5 and 5.0 mg PrP/L water) and maintained semi-statically for 14 days. Afterwards, apical measurements (body weight (BW), total body length (BL), snout to vent length (SVL) and hind limb length (HLL)) and reached developmental stage were assessed. In addition, mRNA expression of HPT axis relevant genes encoding deiodinase 2 (D2, hepatic tissue), deiodinase 3 (D3, hepatic and tail tissue) and transthyretin (Ttr, hepatic tissue) were measured by quantitative reverse transcription PCR (qRT-PCR). The PrP exposure did not affect general growth and development, but it did cause a downregulation of dio3 and ttr. The downregulation of dio3 could possibly be associated with a reduced serum content of thyroid hormone, while ttr might be connected to a previously described xenoestrogenic effect of PrP in vitro and in fish.

Subjects/Keywords: Xenopus; Thyroid hormones; Endocrine disruption; Amphibian metamorphosis assay; Propylparaben; Hormonstörande ämnen; Propylparaben; Xenopus; Sköldkörtelhormoner

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Pohl, J. (2015). Thyroid Endocrine Disruption of Propylparaben Assessed Using an Optimized Individual Xenopus tropicalis Metamorphosing Tadpole Exposure System. (Thesis). Uppsala University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-267976

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Pohl, Johannes. “Thyroid Endocrine Disruption of Propylparaben Assessed Using an Optimized Individual Xenopus tropicalis Metamorphosing Tadpole Exposure System.” 2015. Thesis, Uppsala University. Accessed August 15, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-267976.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Pohl, Johannes. “Thyroid Endocrine Disruption of Propylparaben Assessed Using an Optimized Individual Xenopus tropicalis Metamorphosing Tadpole Exposure System.” 2015. Web. 15 Aug 2020.

Vancouver:

Pohl J. Thyroid Endocrine Disruption of Propylparaben Assessed Using an Optimized Individual Xenopus tropicalis Metamorphosing Tadpole Exposure System. [Internet] [Thesis]. Uppsala University; 2015. [cited 2020 Aug 15]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-267976.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pohl J. Thyroid Endocrine Disruption of Propylparaben Assessed Using an Optimized Individual Xenopus tropicalis Metamorphosing Tadpole Exposure System. [Thesis]. Uppsala University; 2015. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-267976

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Zahin, Maryam. Studies on antibacterial, antioxidant and antimutagenic activities of certain Indian medicinal plants; -.

Degree: Agricultural Microbiology, 2010, Aligarh Muslim University

Abstract not available newline

Summaru p. i-xv, Bibliography p.262-311

Advisors/Committee Members: Ahmad, Iqbal.

Subjects/Keywords: Propylparaben; Chemical; Fractions; Polyphenolic; Phenolic

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Zahin, M. (2010). Studies on antibacterial, antioxidant and antimutagenic activities of certain Indian medicinal plants; -. (Thesis). Aligarh Muslim University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/53988

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Zahin, Maryam. “Studies on antibacterial, antioxidant and antimutagenic activities of certain Indian medicinal plants; -.” 2010. Thesis, Aligarh Muslim University. Accessed August 15, 2020. http://shodhganga.inflibnet.ac.in/handle/10603/53988.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Zahin, Maryam. “Studies on antibacterial, antioxidant and antimutagenic activities of certain Indian medicinal plants; -.” 2010. Web. 15 Aug 2020.

Vancouver:

Zahin M. Studies on antibacterial, antioxidant and antimutagenic activities of certain Indian medicinal plants; -. [Internet] [Thesis]. Aligarh Muslim University; 2010. [cited 2020 Aug 15]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/53988.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zahin M. Studies on antibacterial, antioxidant and antimutagenic activities of certain Indian medicinal plants; -. [Thesis]. Aligarh Muslim University; 2010. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/53988

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


RMIT University

3. Pereira Miranda, A. The effects of Endocrine Disrupting Chemicals (EDCs) on the native Australian fish Murray River rainbow fish (Melanotaenia fluviatilis).

Degree: 2018, RMIT University

Chemicals that have the ability to interfere with the endocrine system of organisms are termed endocrine disrupting chemicals (EDCs). The endocrine system requires a fine and orchestrated control of hormones to further control vital processes such as metabolism, growth or reproduction. This research evaluated the effects of several endocrine disrupting chemicals in the aquatic environment, such as 17α trenbolone, atrazine, propylparaben, pyrimethanil, estrone and 17α estradiol on the reproductive health of the native Australian fish Murray River rainbowfish (Melanotaenia fluviatilis); in response to the severe lack of research on native species. Diverse mixtures of endocrine disruptors were also assessed in order to attain a more realistic case scenario. In breeding groups of fish exposed to 4, 40 and 400 ng/L of the feedlot contaminant 17α trenbolone for 10 and 21 days, vitellogenin concentrations were significantly reduced at 40 ng/L at day 10; and 400 ng/L at the end of the exposure (21 days), highlighting the non-dose response effects of 17α trenbolone. Fecundity was significantly reduced and after 17 days of exposure eye and spinal deformations occurred on and were observed from day 2 after hatching in about 20% of larvae. By the end of the exposure period, gonads of female fish exposed to 400 ng/L of 17α trenbolone showed an increased number of atretic follicles when compared to the control. A further exposure of both male and female M. fluviatilis to 40 and 400 ng/L of 17α trenbolone for 14 days showed a significant decrease in plasma vitellogenin in females. In another experiment, vitellogenin mRNA was induced with exposure to 40 ng/L in male fish and the expression of brain aromatase (cyp19a1b) was significantly induced at both 40 and 400 ng/L of 17α trenbolone. In females, at 40 ng/L a decrease in brain aromatase expression cyp19a1b was observed. In the ovary, the expression of the ovarian aromatase (cyp19a1a) was significantly downregulated at both 40 and 400 ng/L of 17α trenbolone. The exposure of M. fluviatilis eggs to different concentrations of 17α trenbolone (until hatching) resulted in several abnormalities in hatched larvae though there was no dose-response in the percentage of abnormalities observed. Undeveloped eyes, as well as spinal deformations, were observed at exposure concentrations of 31.2, 125 and 500 ng/L. The results indicate that 17α trenbolone may have effects beyond its androgenic action and act also as a genotoxic compound at concentrations commonly found in effluents from feedlots. The effects of 17α trenbolone on both egg and larvae can additionally impair population fitness at relatively low concentrations. When the androgenic chemical 17α trenbolone was mixed with an estrogen, 17β estradiol, for 7 days it was demonstrated that 17α trenbolone was unable to activate the estrogen receptors. When circulatory levels of vitellogenin were…

Subjects/Keywords: Fields of Research; Endocrine Disrupting Chemicals; Water quality; Vitellogenin; Fish; 17α trenbolone; 17β estradiol; Mixtures; Propylparaben; Atrazine; Pyrimethanil; PFOA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Pereira Miranda, A. (2018). The effects of Endocrine Disrupting Chemicals (EDCs) on the native Australian fish Murray River rainbow fish (Melanotaenia fluviatilis). (Thesis). RMIT University. Retrieved from http://researchbank.rmit.edu.au/view/rmit:162475

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Pereira Miranda, A. “The effects of Endocrine Disrupting Chemicals (EDCs) on the native Australian fish Murray River rainbow fish (Melanotaenia fluviatilis).” 2018. Thesis, RMIT University. Accessed August 15, 2020. http://researchbank.rmit.edu.au/view/rmit:162475.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Pereira Miranda, A. “The effects of Endocrine Disrupting Chemicals (EDCs) on the native Australian fish Murray River rainbow fish (Melanotaenia fluviatilis).” 2018. Web. 15 Aug 2020.

Vancouver:

Pereira Miranda A. The effects of Endocrine Disrupting Chemicals (EDCs) on the native Australian fish Murray River rainbow fish (Melanotaenia fluviatilis). [Internet] [Thesis]. RMIT University; 2018. [cited 2020 Aug 15]. Available from: http://researchbank.rmit.edu.au/view/rmit:162475.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pereira Miranda A. The effects of Endocrine Disrupting Chemicals (EDCs) on the native Australian fish Murray River rainbow fish (Melanotaenia fluviatilis). [Thesis]. RMIT University; 2018. Available from: http://researchbank.rmit.edu.au/view/rmit:162475

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.