subject:(Prevention of Type 2 diabetes mellitus)

University of New South Wales

1. Shahid, Farhana. Understanding psycho-social factors influencing lifestyle of women with a history of gestational diabetes in Pakistan.

Degree: Community Medicine, 2012, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/52619 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11292/SOURCE01?view=true

► Lifestyle interventions are proven to be effective in preventing or delaying type 2 diabetes mellitus (T2DM) in high risk individuals, such as women with a… (more)

▼ Lifestyle interventions are proven to be effective in preventing or delaying type 2 diabetes mellitus (T2DM) in high risk individuals, such as women with a history of gestational diabetes mellitus (GDM) referred to henceforth as GDM women. This thesis was designed to address the lack of understanding of factors that affect lifestyle of GDM women in Pakistan and identify suitable approaches for intervention. A series of studies were conducted to develop valid and reliable measures for constructs in the trans-theoretical model (TTM), family support and diet and to test a model for lifestyle change. The study participants were recruited from a tertiary care hospital in Karachi, Pakistan. The qualitative study used in-depth interviews (n=24) and group discussions (n=17) and was analysed thematically. Measures were developed and tested in a cross sectional survey of post-natal women (n=331). Exploratory factor analysis was used to examine the construct validity of measures and Partial least Square (PLS) to predict diet and physical activity of GDM women in Pakistan. The qualitative findings revealed lack of knowledge, social support, cultural expectations and gender role as influencing lifestyle of GDM women. Variables that included TTM constructs (pros and cons, self efficacy and stages of change), family support and selected demographic factors predicted 44 percent of variance in dietary fat intake and 38 percent of physical activity of GDM women. These models explained much less of the variance in non-GDM women. Self-efficacy, cons for change and positive family support were the most significant predicators of dietary behaviour. Self-efficacy and cons for change were significant predictors of physical activity. This study makes an original contribution to the gap in knowledge of factors that affect lifestyle behaviours of GDM women in a South Asian context, and specifically Pakistan. The findings indicate that interventions for GDM women using strategies to improve self efficacy, addressing perceived cons, and using family support would be effective. Culturally specific messages, delivered by a health care provider targeting weight management would be acceptable for GDM women in Pakistan. The findings inform the design of a lifestyle intervention for this target group. Advisors/Committee Members: Jayasuriya, Rohan, Public Health & Community Medicine, Faculty of Medicine, UNSW, Razee, Husna, Public Health & Community Medicine, Faculty of Medicine, UNSW, Iqbal, Romaina, Department of Community Health Sciences, The Aga Khan University, Karachi, Pakistan.

Subjects/Keywords: Prevention of Type 2 diabetes mellitus; Gestational Diabetes Mellitus; Pakistan; Lifestyle; Psycho-social factors

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APA (6^th Edition):

Shahid, F. (2012). Understanding psycho-social factors influencing lifestyle of women with a history of gestational diabetes in Pakistan. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/52619 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11292/SOURCE01?view=true

Chicago Manual of Style (16^th Edition):

Shahid, Farhana. “Understanding psycho-social factors influencing lifestyle of women with a history of gestational diabetes in Pakistan.” 2012. Doctoral Dissertation, University of New South Wales. Accessed January 18, 2021. http://handle.unsw.edu.au/1959.4/52619 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11292/SOURCE01?view=true.

MLA Handbook (7^th Edition):

Shahid, Farhana. “Understanding psycho-social factors influencing lifestyle of women with a history of gestational diabetes in Pakistan.” 2012. Web. 18 Jan 2021.

Vancouver:

Shahid F. Understanding psycho-social factors influencing lifestyle of women with a history of gestational diabetes in Pakistan. [Internet] [Doctoral dissertation]. University of New South Wales; 2012. [cited 2021 Jan 18]. Available from: http://handle.unsw.edu.au/1959.4/52619 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11292/SOURCE01?view=true.

Council of Science Editors:

Shahid F. Understanding psycho-social factors influencing lifestyle of women with a history of gestational diabetes in Pakistan. [Doctoral Dissertation]. University of New South Wales; 2012. Available from: http://handle.unsw.edu.au/1959.4/52619 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11292/SOURCE01?view=true

Texas A&M University

2. Spears, Erica Charlot. Stuck in the Middle: A Mixed-Methods Study Examining the Role of Specific Health Knowledge and Perceived Risk in the African American Type 2 Diabetes Mellitus Health Disparity.

Degree: PhD, Health Education, 2017, Texas A&M University

URL: http://hdl.handle.net/1969.1/187244

► African Americans are disproportionately represented in the United States’ Type 2 Diabetes Mellitus (T2DM) statistics. This disparity has long been investigated, but no marked improvement… (more)

▼ African Americans are disproportionately represented in the United States’ Type 2 Diabetes Mellitus (T2DM) statistics. This disparity has long been investigated, but no marked improvement has been made. This study examines knowledge gaps, perceptions of risk and conditions contributing to the persistence of this disparity, utilizing a mixed-methods approach. This study examines T2DM knowledge and perceptions of risk in middle-class, African Americans living in New Orleans, Louisiana. Specifically, this study: 1) examines the T2DM prevention literature; 2) assesses knowledge levels, and perceptions of severity and susceptibility to T2DM in non-diabetic, or asymptomatic, middle-class African Americans; 3) explores the role of built environments on health behaviors; and 4) examines attitudes and feelings of self-efficacy in relation to preventative health strategies that may deter the development of T2MD. This study found that the majority of the T2DM literature focused on the treatment of T2DM complications (n=177), not prevention of the disease (n=101). Study designs for T2DM prevention varied widely, from pilot and feasibility studies (n=9) to randomized control trials (n=10); the largest study type, however, was observational (n=19). None of the studies reviewed focused on middle-class African Americans. Income levels or socioeconomic status were largely unspecified (n=62). The study did not find a correlation between participants’ perceptions of risk and actual risk, based on the ADA’s risk assessment (p =.110). There was a statistically significant, negative correlation (p = -.748) found between ADA risk totals and age, with significance set at the 0.01 level. There was also a statistically significant, negative correlation (p = -.214) found between T2DM risks and participant education levels, with significance set at the .05 level. At large, participants expressed a perceived severity of T2DM. Participants noted, however, that the condition has become somewhat normalized in the African American community. Respondents generally felt sufficiently informed about the condition, which contributed to feelings of high self-efficacy and low levels of concern for developing T2DM. There were knowledge gaps and misinformation that provide grounds for re-evaluating those feelings, however. Advisors/Committee Members: Guidry, Jeffrey J (advisor), Harvey, Idethia S (advisor), Han, Daikwon (committee member), Street, Richard L (committee member).

Subjects/Keywords: African American; Type 2 Diabetes Mellitus; Type 2 Diabetes; Diabetes; Diabetes Prevention; middle-class; perceived risk; diabetes knowledge.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Spears, E. C. (2017). Stuck in the Middle: A Mixed-Methods Study Examining the Role of Specific Health Knowledge and Perceived Risk in the African American Type 2 Diabetes Mellitus Health Disparity. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/187244

Chicago Manual of Style (16^th Edition):

Spears, Erica Charlot. “Stuck in the Middle: A Mixed-Methods Study Examining the Role of Specific Health Knowledge and Perceived Risk in the African American Type 2 Diabetes Mellitus Health Disparity.” 2017. Doctoral Dissertation, Texas A&M University. Accessed January 18, 2021. http://hdl.handle.net/1969.1/187244.

MLA Handbook (7^th Edition):

Spears, Erica Charlot. “Stuck in the Middle: A Mixed-Methods Study Examining the Role of Specific Health Knowledge and Perceived Risk in the African American Type 2 Diabetes Mellitus Health Disparity.” 2017. Web. 18 Jan 2021.

Vancouver:

Spears EC. Stuck in the Middle: A Mixed-Methods Study Examining the Role of Specific Health Knowledge and Perceived Risk in the African American Type 2 Diabetes Mellitus Health Disparity. [Internet] [Doctoral dissertation]. Texas A&M University; 2017. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1969.1/187244.

Council of Science Editors:

Spears EC. Stuck in the Middle: A Mixed-Methods Study Examining the Role of Specific Health Knowledge and Perceived Risk in the African American Type 2 Diabetes Mellitus Health Disparity. [Doctoral Dissertation]. Texas A&M University; 2017. Available from: http://hdl.handle.net/1969.1/187244

Georgia State University

3. Shah, Payal S. Awareness of Diabetes Risk and Adoption of Diabetes Risk Reduction Behaviors in the Presence of Other Risk Factors in U.S Adults: An Examination of NHANES Data 2007-2008.

Degree: MPH, Public Health, 2011, Georgia State University

URL: https://scholarworks.gsu.edu/iph_theses/188

► ABSTRACT Background: Prediabetes is a precursor condition to type 2 diabetes mellitus. Previous research and clinical trials have shown that the onset of type… (more)

▼ ABSTRACT Background: Prediabetes is a precursor condition to type 2 diabetes mellitus. Previous research and clinical trials have shown that the onset of type 2 diabetes could be delayed or prevented through structured life style modifications such as dietary changes, modest weight loss and moderate-intensity exercise. This study examines U.S adults of different ethnicities that include non-Hispanic white, non-Hispanic black and Mexican Americans and whether their awareness of diabetes risk is associated with their participation in diabetes risk reduction behavior, a combination of physical activity, weight control and fat/calories intake. Methods: The 2007-2008 National Health and Nutrition Examination Survey, NHANES, was used to conduct a cross-sectional study of 4083 U.S. adults who were 20 years old and above and were aware of their diabetes risk. The association between the awareness of one’s diabetes risk and the adoption of diabetes risk reduction behavior were examined in present of other risk factors such as age, gender, ethnicity, education, annual family income, BMI, hypertension, mean systolic blood pressure, mean diastolic blood pressure, total cholesterol, LDL, HDL and triglyceride levels. Males and females were examined separately for all analyses performed. Cross tabulation was conducted and p-values were calculated by the Pearson’s chi-square test for the categorical variables which include gender, ethnicity, education, annual family income, adiposity and hypertension. One Way ANOVA and Tukey post hoc tests were conducted for the continuous variables which include age, mean systolic blood pressure, mean diastolic blood pressure, total cholesterol, LDL, HDL and triglyceride levels. Univariate and multivariate analyses were performed to determine the association between the main independent variable, awareness of one’s diabetes risk, and the dependent variable, adoption of diabetes risk reduction behavior, controlling for other risk factors. A p-value of <0.05 and 95% confidence intervals were used to determine statistical significance throughout all analyses performed. Results: After controlling for age, gender, race, education, annual family income, BMI, hypertension, mean systolic blood pressure, mean diastolic blood pressure, total cholesterol, LDL, HDL, and triglycerides, results from the multivariate analysis showed that subjects who were aware of their diabetes risk were more likely to adopt diabetes risk reduction behavior (OR= 1,734, 95 % CI=1.217-2.470). Females and non-Hispanic blacks, who were aware of their diabetes risk, were also more likely to adopt diabetes risk reduction behavior compared to males, non-Hispanic whites and Mexican Americans. An increase in the levels of education, annual family income and BMI was also associated with the adoption of diabetes risk reduction behavior. Stratification according to gender and ethnicity, showed that Mexican American males and females were more… Advisors/Committee Members: Ike S. Okosun, Frances McCarty.

Subjects/Keywords: NHANES; prediabetes; type 2 diabetes mellitus; prevention; intervention; ethnicity; Public Health

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shah, P. S. (2011). Awareness of Diabetes Risk and Adoption of Diabetes Risk Reduction Behaviors in the Presence of Other Risk Factors in U.S Adults: An Examination of NHANES Data 2007-2008. (Thesis). Georgia State University. Retrieved from https://scholarworks.gsu.edu/iph_theses/188

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shah, Payal S. “Awareness of Diabetes Risk and Adoption of Diabetes Risk Reduction Behaviors in the Presence of Other Risk Factors in U.S Adults: An Examination of NHANES Data 2007-2008.” 2011. Thesis, Georgia State University. Accessed January 18, 2021. https://scholarworks.gsu.edu/iph_theses/188.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shah, Payal S. “Awareness of Diabetes Risk and Adoption of Diabetes Risk Reduction Behaviors in the Presence of Other Risk Factors in U.S Adults: An Examination of NHANES Data 2007-2008.” 2011. Web. 18 Jan 2021.

Vancouver:

Shah PS. Awareness of Diabetes Risk and Adoption of Diabetes Risk Reduction Behaviors in the Presence of Other Risk Factors in U.S Adults: An Examination of NHANES Data 2007-2008. [Internet] [Thesis]. Georgia State University; 2011. [cited 2021 Jan 18]. Available from: https://scholarworks.gsu.edu/iph_theses/188.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shah PS. Awareness of Diabetes Risk and Adoption of Diabetes Risk Reduction Behaviors in the Presence of Other Risk Factors in U.S Adults: An Examination of NHANES Data 2007-2008. [Thesis]. Georgia State University; 2011. Available from: https://scholarworks.gsu.edu/iph_theses/188

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Aberdeen

4. Mathur, Aditi. Genetic association between schizophrenia and type-2 diabetes.

Degree: PhD, 2011, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=167136 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542644

► Aims: This PhD project was designed under two studies, the genetic association study to investigate a genetic component or a genetic pathway that might be… (more)

▼ Aims: This PhD project was designed under two studies, the genetic association study to investigate a genetic component or a genetic pathway that might be associated with both schizophrenia and type-2 diabetes (T2D). The gene functional study to explore whether clozapine could affect expression of the genes associated with obesity and T2D. Methods: In genetic association study, a total of 17 single nucleotide polymorphisms (SNPs) were genotyped in the PPARG, PLA2G4A, PTGS2 and AKT1 genes in 221 British nuclear families. In the gene functional study, U937 cells were treated with clozapine (1g/ml and 2g/ml) for 48 hours and 96 hours. Quantitative real-time PCR analysis was used to measure the mRNA expression levels of the genes of interest in clozapine-treated and untreated cells. Results: Eight SNPs tested across the PPARG gene did not show allelic association with schizophrenia. An association was detected at rs2745557 in the PTGS2 locus (2=4.19, p= 0.041) and rs10798059 in the PLA2G4A locus (2=4.28, p=0.039), but these associations did not survive after 10,000 permutations (global p=0.246). Allelic association for the AKT1 gene was detected at rs1130214 (2=6.28, p=0.012) and at rs11847866 (2=4.64, p=0.031) only although the global p-value of overall associations for the AKT1 was 0.059 after 10,000 permutations. Haplotype analysis showed a disease association for the rs1130214-rs2494746-rs11847866 haplotypes (2= 10.18, df= 4, p=0.037), of which the T-G-A haplotype was excessively transmitted (2=6.93, p=0.008) and this haplotypic association survived the Bonferroni correction (p=0.04). The expression of the MTCH2 gene showed a significant decrease in mRNA expression (combined p=0.001) and that of the PPARG gene showed a significant increase (combined p=0.005) in the cells treated with 1g/ml clozapine for 96 hours. Conclusions: The present results support the AKT1 gene association with schizophrenia as reported in previous studies; both the MTCH2 and PPARG genes may be involved in the development of clozapine-induced obesity and in an increased risk of T2D.

Subjects/Keywords: Diabetes Mellitus; Type 2 : Schizophrenia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mathur, A. (2011). Genetic association between schizophrenia and type-2 diabetes. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=167136 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542644

Chicago Manual of Style (16^th Edition):

Mathur, Aditi. “Genetic association between schizophrenia and type-2 diabetes.” 2011. Doctoral Dissertation, University of Aberdeen. Accessed January 18, 2021. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=167136 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542644.

MLA Handbook (7^th Edition):

Mathur, Aditi. “Genetic association between schizophrenia and type-2 diabetes.” 2011. Web. 18 Jan 2021.

Vancouver:

Mathur A. Genetic association between schizophrenia and type-2 diabetes. [Internet] [Doctoral dissertation]. University of Aberdeen; 2011. [cited 2021 Jan 18]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=167136 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542644.

Council of Science Editors:

Mathur A. Genetic association between schizophrenia and type-2 diabetes. [Doctoral Dissertation]. University of Aberdeen; 2011. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=167136 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542644

5. Suyanne Freire de MacÃdo. Diabetes Mellitus Tipo 2 : investigaÃÃo dos fatores de risco em crianÃas de escolas pÃblicas de Fortaleza-CearÃ.

Degree: Master, 2009, Universidade Federal do Ceará

URL: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=5711 ;

►

Objetivou-se investigar fatores de risco para diabetes mellitus tipo 2, em uma populaÃÃo de crianÃas de escolas pÃblicas de Fortaleza. Estudo transversal realizado de marÃo… (more)

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Objetivou-se investigar fatores de risco para diabetes mellitus tipo 2, em uma populaÃÃo de crianÃas de escolas pÃblicas de Fortaleza. Estudo transversal realizado de marÃo a junho de 2008, com 727 crianÃas, de 6 a 11 anos, matriculadas em doze escolas pÃblicas. Utilizou-se um formulÃrio para registrar dados de identificaÃÃo e as medidas antropomÃtricas avaliadas. Os dados sofreram tripla digitaÃÃo e foram analisados conforme literatura especÃfica. Atenderam-se Ãs recomendaÃÃes das Diretrizes e Normas da Pesquisa em Seres Humanos. Foram mensurados: peso, altura, circunferÃncia da cintura, glicemia capilar e pressÃo arterial. Conforme os resultados evidenciaram 54,1% dos participantes eram do sexo feminino, 15,1% tinham sobrepeso, 6,6% obesidade, 27% obesidade central, 6,2% alteraÃÃes na glicemia capilar e 17,9% nÃveis de pressÃo arterial elevados. Os dados em relaÃÃo ao nÃmero de fatores de risco apresentados por cada crianÃa apontam que 53,4% nÃo possuÃam os fatores de risco investigados, entretanto, 24,3% tinham pelo menos um fator, 18,8% dois, 3,2% trÃs e 0,3% quatro. NÃo houve diferenÃas estatisticamente significantes entre os fatores de risco pesquisados quanto ao gÃnero e Ã faixa etÃria. Essa investigaÃÃo permitiu conhecer a frequÃncia dos fatores de risco para DM2 em crianÃas de Fortaleza-CearÃ e os resultados apontam para a necessidade de aÃÃes de promoÃÃo da saÃde imediatas. A enfermagem pode intervir efetivamente por meio de aÃÃes de educaÃÃo em saÃde, incentivando a adoÃÃo de hÃbitos de vida mais saudÃveis, bem como desenvolvendo, durante as consultas de enfermagem, a pesquisa dos fatores de risco para DM2. Dessa forma, serÃ possÃvel reduzir agravos, prevenir o surgimento do DM2 e promover a saÃde.

This study aims to investigate the risk factors for type 2 diabetes in a population of public schools children of Fortaleza. A transverse study was made from March to June 2008, with 727 6 to 11 yars-old children from twelve public schools. A form was used to register personal data and the anthropometric evaluated mesures. The data was typed three times and analyzed in accord with a specific literatura and also followed the Diretrizes e Normas de Pesquisa em Seres Humanosâs recommendations. The data was composed by some mesures like weight, height, capillary glucose, blood pressure and waist circumference. The results indicate that 54,1% of the children were femele, 15,1% overweight, 6,6% obese, 27% abdominal obese, 6,2% showed alterations in capillary glucose and 17% hight blood presure leves. The data regarding the numb of risk factors present by each child, points that 53,4% of them didnât have none of the investigated factors. However, 24,3% of the children had at least one factor 18,8%, two, 3,2% three e 0,3% four associated factores. There were no significant differences between genders and age-groups.This research allowed us to know the risk factors frequency to DM2 in children of Fortaleza and the results reveal the necessity of immediate health promotion. The nursing can intervene by health education…

Advisors/Committee Members: Lucia de Fatima da Silva, EscolÃstica Rejane Ferreira Moura, Marcos VenÃcios de Oliveira Lopes, Marta Maria Coelho Damasceno.

Subjects/Keywords: ENFERMAGEM; Diabetes Mellitus tipo 2; Fatores de risco; SaÃde da crianÃa; PrevenÃÃo; Diabetes mellitus type 2; Risk factors; Children Health; Prevention

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

MacÃdo, S. F. d. (2009). Diabetes Mellitus Tipo 2 : investigaÃÃo dos fatores de risco em crianÃas de escolas pÃblicas de Fortaleza-CearÃ. (Masters Thesis). Universidade Federal do Ceará. Retrieved from http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=5711 ;

Chicago Manual of Style (16^th Edition):

MacÃdo, Suyanne Freire de. “Diabetes Mellitus Tipo 2 : investigaÃÃo dos fatores de risco em crianÃas de escolas pÃblicas de Fortaleza-CearÃ.” 2009. Masters Thesis, Universidade Federal do Ceará. Accessed January 18, 2021. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=5711 ;.

MLA Handbook (7^th Edition):

MacÃdo, Suyanne Freire de. “Diabetes Mellitus Tipo 2 : investigaÃÃo dos fatores de risco em crianÃas de escolas pÃblicas de Fortaleza-CearÃ.” 2009. Web. 18 Jan 2021.

Vancouver:

MacÃdo SFd. Diabetes Mellitus Tipo 2 : investigaÃÃo dos fatores de risco em crianÃas de escolas pÃblicas de Fortaleza-CearÃ. [Internet] [Masters thesis]. Universidade Federal do Ceará 2009. [cited 2021 Jan 18]. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=5711 ;.

Council of Science Editors:

MacÃdo SFd. Diabetes Mellitus Tipo 2 : investigaÃÃo dos fatores de risco em crianÃas de escolas pÃblicas de Fortaleza-CearÃ. [Masters Thesis]. Universidade Federal do Ceará 2009. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=5711 ;

Louisiana State University

6. Wang, Yujie. A Cohort Study of a History of Gestational Diabetes Mellitus and the Risk of Incident Type 2 Diabetes in Louisiana Women.

Degree: MS, Human Ecology, 2011, Louisiana State University

URL: etd-07012011-144141 ; https://digitalcommons.lsu.edu/gradschool_theses/178

► Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications. It has been shown that a history of GDM is associated with an… (more)

Subjects/Keywords: gestational diabetes mellitus; type 2 diabetes; Louisiana

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, Y. (2011). A Cohort Study of a History of Gestational Diabetes Mellitus and the Risk of Incident Type 2 Diabetes in Louisiana Women. (Masters Thesis). Louisiana State University. Retrieved from etd-07012011-144141 ; https://digitalcommons.lsu.edu/gradschool_theses/178

Chicago Manual of Style (16^th Edition):

Wang, Yujie. “A Cohort Study of a History of Gestational Diabetes Mellitus and the Risk of Incident Type 2 Diabetes in Louisiana Women.” 2011. Masters Thesis, Louisiana State University. Accessed January 18, 2021. etd-07012011-144141 ; https://digitalcommons.lsu.edu/gradschool_theses/178.

MLA Handbook (7^th Edition):

Wang, Yujie. “A Cohort Study of a History of Gestational Diabetes Mellitus and the Risk of Incident Type 2 Diabetes in Louisiana Women.” 2011. Web. 18 Jan 2021.

Vancouver:

Wang Y. A Cohort Study of a History of Gestational Diabetes Mellitus and the Risk of Incident Type 2 Diabetes in Louisiana Women. [Internet] [Masters thesis]. Louisiana State University; 2011. [cited 2021 Jan 18]. Available from: etd-07012011-144141 ; https://digitalcommons.lsu.edu/gradschool_theses/178.

Council of Science Editors:

Wang Y. A Cohort Study of a History of Gestational Diabetes Mellitus and the Risk of Incident Type 2 Diabetes in Louisiana Women. [Masters Thesis]. Louisiana State University; 2011. Available from: etd-07012011-144141 ; https://digitalcommons.lsu.edu/gradschool_theses/178

Colorado State University

7. Dawson, Christine. Type II diabetes mellitus self-management: relating diabetes distress, social support, self-efficacy, and performance of diabetes self-care activities.

Degree: MS(M.S.), Occupational Therapy, 2020, Colorado State University

URL: http://hdl.handle.net/10217/208472

► Type 2 Diabetes Mellitus (T2DM) is a widespread chronic disease that negatively impacts an individual's health and well-being, particularly when uncontrolled. Due to the nature… (more)

Subjects/Keywords: type 2 diabetes mellitus; diabetes self-management

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APA (6^th Edition):

Dawson, C. (2020). Type II diabetes mellitus self-management: relating diabetes distress, social support, self-efficacy, and performance of diabetes self-care activities. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/208472

Chicago Manual of Style (16^th Edition):

Dawson, Christine. “Type II diabetes mellitus self-management: relating diabetes distress, social support, self-efficacy, and performance of diabetes self-care activities.” 2020. Masters Thesis, Colorado State University. Accessed January 18, 2021. http://hdl.handle.net/10217/208472.

MLA Handbook (7^th Edition):

Dawson, Christine. “Type II diabetes mellitus self-management: relating diabetes distress, social support, self-efficacy, and performance of diabetes self-care activities.” 2020. Web. 18 Jan 2021.

Vancouver:

Dawson C. Type II diabetes mellitus self-management: relating diabetes distress, social support, self-efficacy, and performance of diabetes self-care activities. [Internet] [Masters thesis]. Colorado State University; 2020. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10217/208472.

Council of Science Editors:

Dawson C. Type II diabetes mellitus self-management: relating diabetes distress, social support, self-efficacy, and performance of diabetes self-care activities. [Masters Thesis]. Colorado State University; 2020. Available from: http://hdl.handle.net/10217/208472

Boston University

8. Schmidt, Anna. Lifestyle intervention vs. metformin in the maintenance of normoglycemia in prediabetic adolescents.

Degree: MS, Physician Assistant Program, 2017, Boston University

URL: http://hdl.handle.net/2144/26899

► INTRODUCTION: Type 2 diabetes mellitus (T2DM), once thought to be an adult disease, now affects large numbers of children. The prevalence of T2DM in children… (more)

▼ INTRODUCTION: Type 2 diabetes mellitus (T2DM), once thought to be an adult disease, now affects large numbers of children. The prevalence of T2DM in children increased 35% between 2001 and 20091 and while it appears to now be leveling off, it is clear that much of the burden of disease falls disproportionately on ethnic minorities. It is well known that there are changes occurring in the microvasculature well before diabetes is diagnosed, and these changes are thought to contribute to micro- and macrovascular complications. Therefore, prediabetes, which is a time of mild hyperglycemia that exists between normal glucose metabolism and overt diabetes, provides a target for behavior modification and potentially the prevention of complications. The mainstay of treatment for diabetes has been lifestyle intervention and treatment with metformin. Research has shown that both intensive lifestyle interventions and metformin are effective for the treatment of T2DM. However, much of this knowledge comes from studies on adults and is simply inferred to youth. Thus, at this time it is still unknown to what extent treatments including lifestyle intervention and metformin should be used, or how they should be utilized, in youth. This is especially true for youth with prediabetes, as this is likely where prevention of the disease needs to occur to have the greatest overall benefit. PROPOSED STUDY: Thus, the proposed study will directly compare two groups treated with standard of care and either metformin daily or intensive lifestyle intervention with a CrossFit™ training modality. The primary outcome is treatment failure and development of diabetes. A secondary outcome is achievement of normoglycemia and its durability. CONCLUSIONS: This study will be the first to examine the longer term outcomes of the use of metformin in youth as well as the effects of high intensity functional training (HIFT) using the CrossFit™ modality. While there is accumulating evidence about the safety of the use of metformin in youth, most studies are of short duration and this study will provide longer term results. Additionally, CrossFit™, a relatively new exercise modality, has not been tested in the literature on youth and as a form of combined aerobic and resistance training, it may provide and effective and interesting means of lifestyle intervention and reversion to normoglycemia in adolescents. In conclusion the results from this study will provide significant clinical relevance.

Subjects/Keywords: Health care management; Adolescents; Children; Obesity; Prediabetes; Prevention; Type 2 diabetes mellitus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schmidt, A. (2017). Lifestyle intervention vs. metformin in the maintenance of normoglycemia in prediabetic adolescents. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/26899

Chicago Manual of Style (16^th Edition):

Schmidt, Anna. “Lifestyle intervention vs. metformin in the maintenance of normoglycemia in prediabetic adolescents.” 2017. Masters Thesis, Boston University. Accessed January 18, 2021. http://hdl.handle.net/2144/26899.

MLA Handbook (7^th Edition):

Schmidt, Anna. “Lifestyle intervention vs. metformin in the maintenance of normoglycemia in prediabetic adolescents.” 2017. Web. 18 Jan 2021.

Vancouver:

Schmidt A. Lifestyle intervention vs. metformin in the maintenance of normoglycemia in prediabetic adolescents. [Internet] [Masters thesis]. Boston University; 2017. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2144/26899.

Council of Science Editors:

Schmidt A. Lifestyle intervention vs. metformin in the maintenance of normoglycemia in prediabetic adolescents. [Masters Thesis]. Boston University; 2017. Available from: http://hdl.handle.net/2144/26899

9. Dube, Urvashi. Identification of genetic loci associated with risk for type 2 diabetes mellitus T2DM in Indians from Rajasthan; -.

Degree: Bilogical Sciene, 2014, INFLIBNET

URL: http://shodhganga.inflibnet.ac.in/handle/10603/24942

►

The global epidemic of type 2 diabetes is increasing at an alarming rate in both newlinedeveloped and developing countries around the world The emerging pandemic… (more)

▼

The global epidemic of type 2 diabetes is increasing at an alarming rate in both newlinedeveloped and developing countries around the world The emerging pandemic is driven by the combined effects of population ageing rising levels of obesity and inactivity and greater longevity among patients with diabetes that is attributable to improved management The micro and macro vascular complications associated with type 2 diabetes account for the majority of the social and economic burden among patients and society more broadly Though the genetic basis of type 2 diabetes is not understood completely the familial nature of the disease is well recognized Studies on newlinehereditary nature of Type 2 Diabetes Mellitus T2DM have indicated both strong and newlinesuggestive linkage signals at loci 2q3237 3q2229 and 10q2526 on chromosome 2 3 newlineand 10 respectively The genetic variations such as single nucleotide polymorphisms newlineSNPs reported in the genes present in these regions are associated slightly with increased risk for type2 diabetes but they only marginally improve the odds of predicting whether an individual will get type2 diabetes based on the traditional newlineclinical characteristics combining age sex and weight Additionally diabetes is known newlineto be influenced by a number of environmental factors that affect body composition markers which in turn are regulated by Quantitative Trait Loci QTLs mapped to these loci as well We have therefore undertaken populationbased genetic screening using microsatellite markers to identify the potential association of these loci with T2DM in North Indian population and to identify the most crucial risk loci among the three associated with the pathogenesis of the disease in North Indians newlineThe study recruited two hundred and ninety one 291 subjects with Type 2 Diabetes newlineMellitus and around four hundred and seventy five 475 unrelated healthy volunteers newlineas controls without any history of diabetes and related comorbidities The subjects were newlineexamined by genotyping using PCRSSLP technique to ascertain disease association

-

Advisors/Committee Members: Kapur, Suman.

Subjects/Keywords: Bilogical Sciene; Identification of Genetic Loci; Type 2 Diabetes Mellitus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dube, U. (2014). Identification of genetic loci associated with risk for type 2 diabetes mellitus T2DM in Indians from Rajasthan; -. (Thesis). INFLIBNET. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/24942

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dube, Urvashi. “Identification of genetic loci associated with risk for type 2 diabetes mellitus T2DM in Indians from Rajasthan; -.” 2014. Thesis, INFLIBNET. Accessed January 18, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/24942.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dube, Urvashi. “Identification of genetic loci associated with risk for type 2 diabetes mellitus T2DM in Indians from Rajasthan; -.” 2014. Web. 18 Jan 2021.

Vancouver:

Dube U. Identification of genetic loci associated with risk for type 2 diabetes mellitus T2DM in Indians from Rajasthan; -. [Internet] [Thesis]. INFLIBNET; 2014. [cited 2021 Jan 18]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/24942.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dube U. Identification of genetic loci associated with risk for type 2 diabetes mellitus T2DM in Indians from Rajasthan; -. [Thesis]. INFLIBNET; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/24942

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Florida

10. Posgai, Amanda L. Evaluating Efficacy and Mechanisms of Combination Therapies for the Prevention and Reversal of Type 1 Diabetes Using the Non-Obese Diabetic Mouse Model of the Disease.

Degree: PhD, Medical Sciences - Immunology and Microbiology (IDP), 2014, University of Florida

URL: https://ufdc.ufl.edu/UFE0047323

► Type 1 Diabetes (T1D) is characterized by the autoimmune destruction of the insulin-producing beta cells of the pancreatic islets leading to glycemic dysregulation which if… (more)

▼ Type 1 Diabetes (T1D) is characterized by the autoimmune destruction of the insulin-producing beta cells of the pancreatic islets leading to glycemic dysregulation which if left untreated, results in diabetic ketoacidosis-induced coma and eventually, death. While patients can learn to manage their condition with exogenous insulin, T1D often leads to severe systemic comorbidities, and to date, there is no available cure. In the past, monotherapies have successfully prevented, and even reversed T1D in the NOD mouse; however, none have proven effective in clinical trials. In many instances, this can be attributed to improper translation of drug dose or treatment regimen, and sometimes, the original findings are not replicable suggesting a need for more rigorous preclinical studies to optimize therapeutic protocols prior to clinical testing. The work detailed in this dissertation aimed to test combinations of candidate reagents for efficacy (in both the prevention and reversal settings) across multiple doses and treatment regimens using the NOD mouse model. In two experiments, we utilized novel transplastomic nicotine-free tobacco plants as vectors for oral protein delivery in prediabetic animals. The first study aimed to induce autoantigen-specific tolerance to glutamic acid decarboxylase and human proinsulin while the second sought to preserve beta cell mass via an incretin hormone, exendin 4, alone or in combination with oral autoantigen therapy, to prevent T1D onset. Two additional experiments were conducted in a multicenter preclinical consortium to test anti-CD20 + oral insulin and anti-CD3 + IL-1 blockade for the reversal of new-onset T1D. While studies of mechanism revealed limited evidence of subclinical immunological, histological, and gut microbial changes as markers of therapeutic effect, each of the therapies tested was unsuccessful in preventing or reversing disease. The oral route may not provide a robust avenue for tolerance induction in an autoimmune-prone host, particularly regarding self-antigen administration, and thus, may require additional combinatorial agents to address this problem. Our findings support the notion that there is a need for larger sample size, dose optimization, and attempts to verify original findings (at more than one institution if possible) in order to identify combination treatment(s) for translation to the clinic. ( en ) Advisors/Committee Members: ATKINSON,MARK A (committee chair), BRUSKO,TODD MICHAEL (committee member), TRIPLETT,ERIC (committee member), SONG,SIHONG (committee member).

Subjects/Keywords: Antigens; Autoantigens; Beta cells; Diabetes complications; Diseases; Immune tolerance; Insulin; Mice; Type 1 diabetes mellitus; Type 2 diabetes mellitus; autoimmune – diabetes – microbiome – nod – prevention – reversal – tolerance

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Posgai, A. L. (2014). Evaluating Efficacy and Mechanisms of Combination Therapies for the Prevention and Reversal of Type 1 Diabetes Using the Non-Obese Diabetic Mouse Model of the Disease. (Doctoral Dissertation). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0047323

Chicago Manual of Style (16^th Edition):

Posgai, Amanda L. “Evaluating Efficacy and Mechanisms of Combination Therapies for the Prevention and Reversal of Type 1 Diabetes Using the Non-Obese Diabetic Mouse Model of the Disease.” 2014. Doctoral Dissertation, University of Florida. Accessed January 18, 2021. https://ufdc.ufl.edu/UFE0047323.

MLA Handbook (7^th Edition):

Posgai, Amanda L. “Evaluating Efficacy and Mechanisms of Combination Therapies for the Prevention and Reversal of Type 1 Diabetes Using the Non-Obese Diabetic Mouse Model of the Disease.” 2014. Web. 18 Jan 2021.

Vancouver:

Posgai AL. Evaluating Efficacy and Mechanisms of Combination Therapies for the Prevention and Reversal of Type 1 Diabetes Using the Non-Obese Diabetic Mouse Model of the Disease. [Internet] [Doctoral dissertation]. University of Florida; 2014. [cited 2021 Jan 18]. Available from: https://ufdc.ufl.edu/UFE0047323.

Council of Science Editors:

Posgai AL. Evaluating Efficacy and Mechanisms of Combination Therapies for the Prevention and Reversal of Type 1 Diabetes Using the Non-Obese Diabetic Mouse Model of the Disease. [Doctoral Dissertation]. University of Florida; 2014. Available from: https://ufdc.ufl.edu/UFE0047323

Universidade Estadual de Campinas

11. Corrêa, Nathália Batista, 1986-. Efeitos do inibidor de SGLT2 dapagliflozina na pressão arterial e perfil hemodinâmico em hipertensos resistentes diabéticos: Effects of SGLT2 inhibitor, dapagliflozin on blood pressure and hemodynamic profile in resistant hypertension subjects.

Degree: 2018, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/335846

► Abstract: Background: Resistant hypertension (HR) is a multifactorial condition characterized by an increased cardiovascular risk phenotype. Frequently, HAR is associated with Type 2 Diabetes (T2DM)… (more)

▼ Abstract: Background: Resistant hypertension (HR) is a multifactorial condition characterized by an increased cardiovascular risk phenotype. Frequently, HAR is associated with Type 2 Diabetes (T2DM) and obesity, which along with lack of blood pressure control, increasing target organ damage (TOD). Thus, new therapeutic approaches to HR treatment are under study. The objective is reducing blood pressure indexes, and consequently, improving cardiovascular prognosis. The new antidiabetic class of inhibitors of SGLT2 results has been shown in recent studies, able to improve cardiovascular parameters, independent of glucose control. Several mechanisms of resistance of antihypertensive therapy may be involved in the improvments shown by this new drug class. The aim of this study was to evaluate the effects of Dapagliflozin, an inhibitor of SGLT2, on blood pressure parameters in patients with HR and T2DM. Methods: Cross-sectional, blind clinical trial for 16 HR patients with T2DM (HbA1c> 6.5%) using metformin. The patients were randomized to receive glibenclamide (5mg / day) or Dapagliflozin (10mg / day) for 12 weeks, in adittion, to antihypertensive therapy. The blood pressure parameters were mesured before and after each intervention, a 30-day interval between treatments was adopted (washout period). Pharmacological compliance and adverse events to medication were also checked. Blood Pressure (BP) office, ambulatory blood pressure (ABPM), Central blood pressure and hemodynamic parameters obtained by Finometer system. Results: 12 months of intervention with glibenclamide and dapagliflozin (SBP: -2 ± 28 vs -8 ± 18 p = 0.61); DBP: -1.5 ± 14 and -16 ± 14 p = 0.82) as well as for a 24 hour BP (SBP: 0 ± 16 vs. -5 ± 15 p = 0.50; 7 ± 11 ± 2 ± 10 p = 0.55), central BP (SBP: -1.7 ± 28 vs -4.5 ± 19 p = 0.81, DBP: -1 ± 13.9 vs -0, 4 ± 11.5 p = 0.88) finometer BP (SBP: -5.8 ± 31.4 vs. -3 ± 33.6 p = 0.88; DBP: -3 ± 16.3 vs. -2 ± 17 , 7 p = 0.94) . Conclusion: Although the use of dapagliflozin does not show diference on BP parameters, after 12 weeks administration in comparision with glibenclamide. It was verified a decrease of at least 10mmHg in SBP in finometer analysis. Studies with a larger population of HR patents can be able to show more promising results for these changes Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Mónica, Fabíola Zakia Taufic, 1980- (other), Rodrigues, Bruno, 1980- (other), Moreno Junior, Heitor, 1958- (advisor), Modolo, Rodrigo Gimenez Pissutti, 1980- (coadvisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Farmacologia (nameofprogram), Rocha, Aloísio Marchi da (committee member), Lopes, Heno Ferreira (committee member).

Subjects/Keywords: Hipertensão; Diabetes mellitus tipo 2; Dapagliflozina; Hypertension; Diabetes Mellitus, Type 2

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Corrêa, Nathália Batista, 1. (2018). Efeitos do inibidor de SGLT2 dapagliflozina na pressão arterial e perfil hemodinâmico em hipertensos resistentes diabéticos: Effects of SGLT2 inhibitor, dapagliflozin on blood pressure and hemodynamic profile in resistant hypertension subjects. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/335846

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Corrêa, Nathália Batista, 1986-. “Efeitos do inibidor de SGLT2 dapagliflozina na pressão arterial e perfil hemodinâmico em hipertensos resistentes diabéticos: Effects of SGLT2 inhibitor, dapagliflozin on blood pressure and hemodynamic profile in resistant hypertension subjects.” 2018. Thesis, Universidade Estadual de Campinas. Accessed January 18, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/335846.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Corrêa, Nathália Batista, 1986-. “Efeitos do inibidor de SGLT2 dapagliflozina na pressão arterial e perfil hemodinâmico em hipertensos resistentes diabéticos: Effects of SGLT2 inhibitor, dapagliflozin on blood pressure and hemodynamic profile in resistant hypertension subjects.” 2018. Web. 18 Jan 2021.

Vancouver:

Corrêa, Nathália Batista 1. Efeitos do inibidor de SGLT2 dapagliflozina na pressão arterial e perfil hemodinâmico em hipertensos resistentes diabéticos: Effects of SGLT2 inhibitor, dapagliflozin on blood pressure and hemodynamic profile in resistant hypertension subjects. [Internet] [Thesis]. Universidade Estadual de Campinas; 2018. [cited 2021 Jan 18]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/335846.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Corrêa, Nathália Batista 1. Efeitos do inibidor de SGLT2 dapagliflozina na pressão arterial e perfil hemodinâmico em hipertensos resistentes diabéticos: Effects of SGLT2 inhibitor, dapagliflozin on blood pressure and hemodynamic profile in resistant hypertension subjects. [Thesis]. Universidade Estadual de Campinas; 2018. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/335846

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Sul

12. Wietzycoski, Cácio Ricardo. Duodenojejunostomia em modelo experimental de diabetes mellitus tipo 2 induzido com estreptozotocina em ratos : repercussões de uma potencial cirurgia metabólica.

Degree: 2011, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/86423

►

O Diabetes Mellitus tipo 2 (DM2) é uma síndrome multifatorial com complicações graves e mortalidade significativa, mas seu tratamento até o momento tem mostrado resultados… (more)

▼

O Diabetes Mellitus tipo 2 (DM2) é uma síndrome multifatorial com complicações graves e mortalidade significativa, mas seu tratamento até o momento tem mostrado resultados desapontadores. Apenas 50% dos pacientes com DM2 conseguem manter níveis glicêmicos adequados. Rubino et al em 2004 demonstraram uma técnica cirúrgica de exclusão duodenojejunal em ratos diabéticos não obesos com bons resultados no controle dos níveis glicêmicos. O desenvolvimento de uma técnica que não apresente perda ponderal pode prover base teórica e científica para justificar sua aplicação em pacientes com DM2 e IMC<35. Com este objetivo, iniciamos um estudo experimental utilizando a técnica proposta por Marchesini em 2008, que consiste na secção do duodeno imediatamente após o piloro, seguido de duodenojejunostomia com anastomose termino-lateral na porção média do intestino delgado. O objetivo foi demonstrar as alterações no perfil metabólico, inflamatório e de estresse oxidativo após a cirurgia metabólica. Foram utilizados 24 ratos Wistar com 2 dias de vida sendo que em 16 deles foi induzido o DM2 através de injeção i.p. de 100mg/kg de Streptozotocina. O desenvolvimento de diabetes foi confirmado após 10 semanas através de TTGIP. Oito ratos diabéticos compuseram o grupo diabético cirúrgico (DM+OP) e oito o grupo diabético controle (DM). Os outros oito animais que não tiveram indução do diabetes formaram o grupo controle clínico (CO). A técnica de Marchesini foi realizada no grupo DM+OP, e os grupos DM e CO receberam dieta padrão e seguimento. Foi realizado TTGIP aos 7, 15, 30, 60 e 90 dias após a cirurgia, quando os animais foram submetidos a eutanásia. Os animais do DM+OP não tiveram perda de peso importante após três meses da cirurgia, enquanto que o DM e o CO tiveram aumento significativo do peso. A glicemia dos animais operados foi significativamente menor no grupo operado em comparação ao diabético controle e os valores de colesterol seguiram a mesma tendência. Os níveis de TNF-α, NF-kB, SOD, TBARS e Catalase foram significativamente menores no grupo DM+OP em relação ao grupo DM. A duodenojejunostomia foi efetiva em controlar os níveis de glicemia e colesterol, bem como diminuiu significativamente os marcadores inflamatórios e de estresse oxidativo.

Diabetes Mellitus type 2 (DMT2) is a multifactorial syndrome with severe complications and significant mortality. Until this moment, its treatment has proven disappointing. Only 50% of DM2 patients are able to maintain proper glycemic levels. In 2004 Rubino et al showed a surgical technique of duodenal-jejunal exclusion in diabetic non-obese rats with positive results in the control of glycemic levels. The development of a technique that does not imply weight loss may provide a theoretical and scientific basis for its application in DM2 patients who present BMI<35. With this aim, this experimental study was conducted using the technique proposed by Marchesini in 2008, which consists of a section of the duodenum immediately next to the pylorus, followed by duodenojejunostomy with…

Advisors/Committee Members: Trindade, Manoel Roberto Maciel.

Subjects/Keywords: Diabetes mellitus experimental; Metabolic surgery; Diabetes mellitus tipo 2; Induction of diabetes; Estreptozocina; Diabetes mellitus type 2 models; Diabetes surgery; Ratos; Metabolismo; Oxidative stress; Duodenostomia; Jejunostomia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wietzycoski, C. R. (2011). Duodenojejunostomia em modelo experimental de diabetes mellitus tipo 2 induzido com estreptozotocina em ratos : repercussões de uma potencial cirurgia metabólica. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/86423

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wietzycoski, Cácio Ricardo. “Duodenojejunostomia em modelo experimental de diabetes mellitus tipo 2 induzido com estreptozotocina em ratos : repercussões de uma potencial cirurgia metabólica.” 2011. Thesis, Universidade do Rio Grande do Sul. Accessed January 18, 2021. http://hdl.handle.net/10183/86423.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wietzycoski, Cácio Ricardo. “Duodenojejunostomia em modelo experimental de diabetes mellitus tipo 2 induzido com estreptozotocina em ratos : repercussões de uma potencial cirurgia metabólica.” 2011. Web. 18 Jan 2021.

Vancouver:

Wietzycoski CR. Duodenojejunostomia em modelo experimental de diabetes mellitus tipo 2 induzido com estreptozotocina em ratos : repercussões de uma potencial cirurgia metabólica. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2011. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10183/86423.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wietzycoski CR. Duodenojejunostomia em modelo experimental de diabetes mellitus tipo 2 induzido com estreptozotocina em ratos : repercussões de uma potencial cirurgia metabólica. [Thesis]. Universidade do Rio Grande do Sul; 2011. Available from: http://hdl.handle.net/10183/86423

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Gothenburg / Göteborgs Universitet

13. Björk, Anna. Congenital Heart Disease, Type 1 and Type 2 Diabetes Mellitus.

Degree: 2020, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/63285

► Worldwide, 1% of all live born children are born with a congenital heart disease (CHD) and currently >95% reach adulthood due to better diagnostics and… (more)

▼ Worldwide, 1% of all live born children are born with a congenital heart disease (CHD) and currently >95% reach adulthood due to better diagnostics and medical care. At the same time, Diabetes Mellitus (DM), type 1 (T1DM) and type 2 (T2DM), is increasing worldwide. The incidence of the endocrine disease T2DM, which makes up more than 90% of all diabetes increases in particular and is part of the metabolic syndrome. T2DM is due to a decrease in insulin sensitivity and insulin production depending on genetic factors as well as obesity and a sedentary lifestyle. T1DM is an autoimmune disease that can develop due to i.e. genetic factors, exposure to infections and stress-strain leading to an autoimmune response. The incidence of T1DM in patients with CHD is unknown and the incidence of T2DM in patients with CHD is previously not extensively studied. Also, the effect of T1DM and T2DM in the CHD population on mortality is unknown. The aim of this thesis was to in large reliable registers and cohorts investigate the prevalence and incidence of T1DM and T2DM in a CHD population, and how this influences the mortality and morbidity in patients with CHD and T1DM and T2DM. Paper I, a retrospective comparative cohort study, investigated the risk of concurrent CHD in patients with T2DM, regarding T2DM onset, mortality and morbidity compared with patients with T2DM without CHD. The study combined data from the National Diabetes Register (NDR), National Patient Register (NPR) and the Cause of Death Register (CDR). Out of patients with T2DM, 833 patients with CHD were matched with 5 controls without CHD, matched by sex, year of birth and year of entry in to the NDR. CHD patients had significantly lower body mass index (BMI), higher creatinine and were more sedentary as compared to patients with T2DM but without CHD. The overall mortality was 26.2% for CHD patients as compared with 19.9% (P<0.001) for the control group, and five-year mortality rates were 5.2% for patients with CHD and T2DM com- pared to 3.4% (P=0.014) in the controls. In conclusion, CHD and secondary risk factors for cardiovascular disease frequently coexist and the development of T2DM in the adult CHD population is not uncommon with an estimated prevalence of between 4 and 8%. Treatment of conventional cardiovascular risk factors in patients with CHD could be considered important given the relatively high morbidity and high risk for mortality observed in patients with the com- bination of CHD and T2DM. Paper II, a retrospective comparative cohort study investigated the risk of concurrent CHD in patients with T1DM, regarding T1DM onset, mortality and morbidity compared to patients with T1DM without CHD. The study combined data from the National Diabetes Register (NDR), National Patient Register (NPR) and the Cause of Death Register (CDR). Out of patients with T1DM, a total of 104 patients with CHD were matched with 520 controls without CHD, matched by sex, year of birth and year of entry in to the NDR. Patients with CHD and T1DM had an earlier onset of…

Subjects/Keywords: Congenital Heart Disease; Diabetes Mellitus; Type 1 Diabetes Mellitus; Type 2 Diabetes Mellitus; Mortality; Morbidity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Björk, A. (2020). Congenital Heart Disease, Type 1 and Type 2 Diabetes Mellitus. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/63285

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Björk, Anna. “Congenital Heart Disease, Type 1 and Type 2 Diabetes Mellitus.” 2020. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed January 18, 2021. http://hdl.handle.net/2077/63285.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Björk, Anna. “Congenital Heart Disease, Type 1 and Type 2 Diabetes Mellitus.” 2020. Web. 18 Jan 2021.

Vancouver:

Björk A. Congenital Heart Disease, Type 1 and Type 2 Diabetes Mellitus. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2020. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2077/63285.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Björk A. Congenital Heart Disease, Type 1 and Type 2 Diabetes Mellitus. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2020. Available from: http://hdl.handle.net/2077/63285

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of the Western Cape

14. Elshawesh, Mohamed Abdallah. The effects of hypoxis hemerocallidea on blood glucose levels in rats with Type 2 diabetes .

Degree: 2015, University of the Western Cape

URL: http://hdl.handle.net/11394/5327

► About 180 million people have been estimated to suffer from type 2 diabetes (T2DM) in 2006 and the annual death rate due to this disease… (more)

▼ About 180 million people have been estimated to suffer from type 2 diabetes (T2DM) in 2006 and the annual death rate due to this disease was 3 million by that time. More than 400 medicinal plants used for the treatment of diabetes mellitus have been recorded, but only a small number of these plants have received scientific and medical evaluation to assess their efficacy. The most common plant used to treat diabetes mellitus is Hypoxis hemerocallidea (HH). The present study was undertaken to investigate the effects of Hypoxis hemerocallidea (HH) on T2DM in rats. Male Wistar rats weighing 200-250 g were used in this experiment. Hypoxis hemerocallidea (HH) corm was used as plant material in the experiment. The study was based on three parts, an acute diabetes study, chronic diabetes study and insulin secretion study. In the acute study, the rats were randomly divided into 2 groups (control and diabetes). The saline solution was added to different concentrations of HH corm to produce concentration of (50, 200, 400, 800 mg/ml). Diabetes was induced by intraperitoneal injections of STZ (65mg/kg). Two weeks after the injection (STZ 65 mg/kg), different concentrations of HHS was administered intraperitoneally after an overnight fast. The blood glucose levels were monitored in the diabetic and control rats at, 30, 60, 120, 180 and 240 minutes post injection. In the chronic study, the rats were randomly divided into 6 different groups (control, HFD, DM, DM-HH, DM-PTHH, and HH). Diabetes mellitus was then induced in the groups of diabetic rats by intraperitoneal injections of STZ (40 mg/kg) and rats were fed a high fat diet (HFD). The body weight of the rats were measured weekly for 7 weeks. An intraperitoneal glucose tolerance test (IPGTT) was performed at the end of week 6. At the end of week 7, rats were killed and serum sample were collected for determination of fatty acid and insulin. Liver and pancreatic tissue was collected for histological evaluation. In the insulin secretion study, Hypoxis hemerocallidea was tested for its effects on insulin secretion by pancreatic islet cells exposed to low (3mM) and high (20mM) glucose medium. Results of the acute study indicated that HHS at a dose 800 mg/ml decreased blood glucose levels fastest in both normal and diabetic rats reaching significance after 30 minutes and 60 minutes respectively and remained below the baseline value until 240 minutes. In the chronic study, it was illustrated that HH had no effect in normal rats on any of the parameters evaluated. Animals in the DM group gained weight the first two weeks, but thereafter began to lose weight. At the end of seven weeks the animals gained significantly less weight than the rest. Animals fed a HFD have more visceral fat compared to the control group. The visceral fat gain occurred in the absence of a significant increase in body weight. We found a markedly lower fasting glucose level in HH treated diabetic animals compared to untreated DM animals. At time zero the blood glucose level of the HFD group… Advisors/Committee Members: Dietrich, Daneel (advisor), Tchokonte-Nana, Venant (advisor).

Subjects/Keywords: Diabetes; Type 2 diabetes mellitus; Insulin resistance; Diabetes Mellitus, Type 2; Streptozotocin; Hypoxis hemerocallidea

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Elshawesh, M. A. (2015). The effects of hypoxis hemerocallidea on blood glucose levels in rats with Type 2 diabetes . (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/5327

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Elshawesh, Mohamed Abdallah. “The effects of hypoxis hemerocallidea on blood glucose levels in rats with Type 2 diabetes .” 2015. Thesis, University of the Western Cape. Accessed January 18, 2021. http://hdl.handle.net/11394/5327.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Elshawesh, Mohamed Abdallah. “The effects of hypoxis hemerocallidea on blood glucose levels in rats with Type 2 diabetes .” 2015. Web. 18 Jan 2021.

Vancouver:

Elshawesh MA. The effects of hypoxis hemerocallidea on blood glucose levels in rats with Type 2 diabetes . [Internet] [Thesis]. University of the Western Cape; 2015. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/11394/5327.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Elshawesh MA. The effects of hypoxis hemerocallidea on blood glucose levels in rats with Type 2 diabetes . [Thesis]. University of the Western Cape; 2015. Available from: http://hdl.handle.net/11394/5327

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Queiroz, Flávia Alline de. Adaptação cultural e validação do instrumento diabetes - 39 (D-39): versão para brasileiros com diabetes mellitus tipo 2 - fase 1.

Degree: Mestrado, Enfermagem Fundamental, 2008, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/22/22132/tde-07072008-111923/ ;

► Diabetes mellitus é considerado um importante problema de saúde pública, que, pelas conseqüências decorrentes de suas complicações e tratamento, poderá afetar a qualidade de vida… (more)

▼ Diabetes mellitus é considerado um importante problema de saúde pública, que, pelas conseqüências decorrentes de suas complicações e tratamento, poderá afetar a qualidade de vida das pessoas acometidas. Os conceitos trazidos pela literatura sobre Qualidade de Vida têm enfocado a percepção das pessoas sobre suas experiências e satisfação em relação a determinadas áreas que compõem a natureza humana. Nas últimas décadas tem crescido o interesse de obter indicadores para avaliar os resultados de intervenções clínicas, de modo a garantir maior resolutividade dos problemas de saúde. Neste contexto surgem os estudos de Qualidade de Vida Relacionada à Saúde, que se constituem em um modelo multidimensional para incluir os vários aspectos da vida humana, no qual a pessoa é fonte primária de informação, para expressar as conseqüências da enfermidade e do tratamento, na sua vida diária. A literatura traz instrumentos gerais e específicos para avaliar a qualidade de vida em relação à saúde. Entendemos que os instrumentos específicos poderão trazer informações direcionadas a realidade que se pretende atuar. Entre os instrumentos específicos de qualidade de vida das pessoas com diabetes, identificou-se o instrumento D-39 para avaliar a qualidade de vida das pessoas com diabetes mellitus. Desta forma, o presente estudo teve como objetivos adaptar o D-39 para a língua portuguesa e desenvolver uma primeira fase do processo de validação, em um estudo piloto. Trata-se de um estudo transversal, de caráter metodológico, com análise psicométrica na simulação do teste de campo para a validade (face, constructo) e a confiabilidade da versão adaptada em uma amostra de brasileiros com diabetes mellitus tipo 2. Este instrumento é composto por 39 itens divididos em cinco domínios (Controle do diabetes, Ansiedade e preocupação, Sobrecarga social, Funcionamento sexual e Energia e mobilidade). O presente estudo foi conduzido em Unidade Básica de Saúde em uma amostra de conveniência, composta por 52 pessoas com diabetes mellitus tipo 2. O processo de adaptação seguiu os seguintes passos metodológicos: tradução do D-39 para a língua portuguesa; avaliação por um Comitê de Juízes; \"back-translationd̈a versão para o inglês, comparação das duas versões em inglês; análise semântica dos itens; préteste da versão adaptada e aplicação da versão final em português entre os participantes. Encontramos predomínio de pessoas do sexo feminino (65,4%), convivendo em companhia 9 conjugal ou com filhos (75%), idade entre 45 e 84 anos, média de 62,8 anos (DP=8,6) e baixa escolaridade (71,1%). Em relação à doença, o tempo médio de duração foi de 9,15 anos (DP=4,2); 23 participantes não faziam uso de insulina (23/52; 44,2%) e 29 faziam (29/52; 55,8%). Quanto às comorbidades, identificamos que 84,6% das pessoas apresentavam sobrepeso e obesidade; o valor médio da pressão arterial sistólica foi de 136,15 mmHg (DP=22) e da diastólica 80,57 mmHg (DP=13,34). Na versão adaptada do instrumento D-39, as respostas variaram de 1 a 7; o intervalo possível, para a soma dos 39… Advisors/Committee Members: Pace, Ana Emilia.

Subjects/Keywords: diabetes mellitus tipo 2; estudos de validação; qualidade de vida; Quality of Life; Type 2 diabetes mellitus; validation studies

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Queiroz, F. A. d. (2008). Adaptação cultural e validação do instrumento diabetes - 39 (D-39): versão para brasileiros com diabetes mellitus tipo 2 - fase 1. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/22/22132/tde-07072008-111923/ ;

Chicago Manual of Style (16^th Edition):

Queiroz, Flávia Alline de. “Adaptação cultural e validação do instrumento diabetes - 39 (D-39): versão para brasileiros com diabetes mellitus tipo 2 - fase 1.” 2008. Masters Thesis, University of São Paulo. Accessed January 18, 2021. http://www.teses.usp.br/teses/disponiveis/22/22132/tde-07072008-111923/ ;.

MLA Handbook (7^th Edition):

Queiroz, Flávia Alline de. “Adaptação cultural e validação do instrumento diabetes - 39 (D-39): versão para brasileiros com diabetes mellitus tipo 2 - fase 1.” 2008. Web. 18 Jan 2021.

Vancouver:

Queiroz FAd. Adaptação cultural e validação do instrumento diabetes - 39 (D-39): versão para brasileiros com diabetes mellitus tipo 2 - fase 1. [Internet] [Masters thesis]. University of São Paulo; 2008. [cited 2021 Jan 18]. Available from: http://www.teses.usp.br/teses/disponiveis/22/22132/tde-07072008-111923/ ;.

Council of Science Editors:

Queiroz FAd. Adaptação cultural e validação do instrumento diabetes - 39 (D-39): versão para brasileiros com diabetes mellitus tipo 2 - fase 1. [Masters Thesis]. University of São Paulo; 2008. Available from: http://www.teses.usp.br/teses/disponiveis/22/22132/tde-07072008-111923/ ;

16. Gonela, Jefferson Thiago. Treinamento com pesos e cargas progressivas em idosos com diabetes mellitus tipo 2.

Degree: PhD, Enfermagem Fundamental, 2014, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/22/22132/tde-03022015-154922/ ;

► Objetivos: Caracterizar os pacientes com diabetes mellitus tipo 2 segundo as variáveis sociodemográficas e clínicas; comparar as variáveis antropométricas e morfológicas, os exames bioquímicos; a… (more)

▼ Objetivos: Caracterizar os pacientes com diabetes mellitus tipo 2 segundo as variáveis sociodemográficas e clínicas; comparar as variáveis antropométricas e morfológicas, os exames bioquímicos; a capacidade funcional; a qualidade de vida e a frequência alimentar, antes e após o treinamento com pesos. Método: A amostra foi constituída por 23 pacientes que participaram de um Programa de Treinamento com pesos. Foram utilizados formulários para obtenção das variáveis sociodemográficas, clínicas, antropométricas e morfológicas; Testes de força máxima de membros inferiores e superiores; Testes para avaliação funcional; Questionário SF-36 e de Frequência Alimentar. O tempo da intervenção foi de 16 semanas, sendo 12 de treinamento e quatro de avaliações. O treinamento ocorreu em três dias por semana; com intensidade moderada de 60 a 80% de uma repetição máxima (1RM), equivalente de oito a 12RM. O volume foi aumentado em número de exercícios com o progresso das fases do treinamento. Resultados: 18 (78,3%) dos pacientes eram mulheres, idade média de 68,3 anos, casada ou com cônjuge, aposentada, com escolaridade média de 5,3 anos de estudo. As comorbidades mais frequentes foram dislipidemia e a hipertensão arterial. Houve manutenção do peso corporal, Índice de massa corporal e circunferência da cintura. Ocorreu aumento da cintura escapular, da área muscular do braço e da perna e da massa isenta de gordura. Constatou-se redução da circunferência do tórax e do percentual de gordura. O índice HOMA-IR diminuiu de 3,8 para 2,8 nos pacientes sem uso de insulina. Observou-se tendência de redução da glicemia inicial durante as 37 sessões do treinamento. Houve melhora da sensibilidade à insulina após o Programa de Treinamento com pesos, com valores menores no final do treinamento. Não houve alterações significativas nos parâmetros de colesterolemia. Houve melhora significativa na maioria dos testes funcionais. No teste de levantar da cadeira cinco vezes, no pré-treinamento, nove pacientes apresentaram tempo superior a 13,6 seg. No pós-treinamento quatro mantiveram o tempo acima, mas dois reduziram o tempo de 16,1 seg e 19,6 seg para 13,9 seg. No teste de força de carga máxima, verificou-se aumento significativo tanto em membros superiores quanto inferiores, com 20,8% e 23,4%, respectivamente. Após o período de treinamento com pesos verificou-se redução significativa da pressão arterial sistólica, tanto em repouso quanto após o esforço dos testes funcionais. A qualidade de vida, segundo o SF-36, melhorou em todos os oito componentes. Houve melhora significativa nos componentes capacidade funcional, 18%; aspectos físicos, 63%; dor, 37,7%; vitalidade, 27,2%; aspectos sociais, 25,6%; e saúde mental, 22,5%. Para os componentes estado geral de saúde e aspectos emocionais houve melhora de 10,5 e 21%, respectivamente, mas sem significância estatística. A capacidade funcional dos pacientes apresentou correlação moderada com o desempenho nos testes físicos finais, coeficiente de Pearson… Advisors/Committee Members: Zanetti, Maria Lucia.

Subjects/Keywords: Diabetes Mellitus tipo 2; Exercício; Exercise; Qualidade de Vida; Quality of Life; Resistance Training; Treinamento Resistido; Type 2 Diabetes Mellitus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gonela, J. T. (2014). Treinamento com pesos e cargas progressivas em idosos com diabetes mellitus tipo 2. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/22/22132/tde-03022015-154922/ ;

Chicago Manual of Style (16^th Edition):

Gonela, Jefferson Thiago. “Treinamento com pesos e cargas progressivas em idosos com diabetes mellitus tipo 2.” 2014. Doctoral Dissertation, University of São Paulo. Accessed January 18, 2021. http://www.teses.usp.br/teses/disponiveis/22/22132/tde-03022015-154922/ ;.

MLA Handbook (7^th Edition):

Gonela, Jefferson Thiago. “Treinamento com pesos e cargas progressivas em idosos com diabetes mellitus tipo 2.” 2014. Web. 18 Jan 2021.

Vancouver:

Gonela JT. Treinamento com pesos e cargas progressivas em idosos com diabetes mellitus tipo 2. [Internet] [Doctoral dissertation]. University of São Paulo; 2014. [cited 2021 Jan 18]. Available from: http://www.teses.usp.br/teses/disponiveis/22/22132/tde-03022015-154922/ ;.

Council of Science Editors:

Gonela JT. Treinamento com pesos e cargas progressivas em idosos com diabetes mellitus tipo 2. [Doctoral Dissertation]. University of São Paulo; 2014. Available from: http://www.teses.usp.br/teses/disponiveis/22/22132/tde-03022015-154922/ ;

17. Karlsson, Carolina. Patienters upplevelser av livskvalitet vid nydiagnostiserad typ 2 Diabetes Mellitus : En intervjustudie.

Degree: Caring Science/Nursing, 2015, Dalarna University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:du-20900

►

Syfte: Att undersöka patienters upplevelser av livskvalitet vid nydiagnostiserad typ 2 Diabetes Mellitus. Metod: En empirisk studie med en kvalitativ ansats som innefattade tio… (more)

▼

Syfte: Att undersöka patienters upplevelser av livskvalitet vid nydiagnostiserad typ 2 Diabetes Mellitus. Metod: En empirisk studie med en kvalitativ ansats som innefattade tio deltagare med nydiagnostiserad typ 2 Diabetes Mellitus. Semistrukturerade intervjuer genomfördes utifrån en intervjuguide där insamlad data analyserades med kvalitativ manifest innehållsanalys. Resultat: Studien resulterade i fyra huvudkategorier och tio subkategorier. Upplevelsen av att få ett diagnosbesked varierade mellan deltagarna, för vissa deltagarna var beskedet inte förvånande medan andra upplevde känslor av chock och förnekelse. Deltagarna upplevde positiva förändringar, exempelvis viktnedgång och förbättrad hälsa men även negativa förändringar, exempelvis att vara beroende av läkemedel. Vissa upplevde ingen förändring alls. Typ 2 Diabetes Mellitus påverkade inte deltagarnas fysiska eller psykiska hälsa i de flesta fall. Deltagarna ansåg det som viktig att få stöd från både omgivningen och hälso- och sjukvården. Konklusion: Känslorna över ett diagnosbesked kunde variera men upplevelsen av livskvalitet påverkades inte av Typ 2 Diabetes Mellitus i de flesta fall i studien. Patientens inställning till att leva med Typ 2 Diabetes Mellitus inverkade på förmågan till att utföra egenvård, och distriktsköterskans stöd och engagemang ansågs vara betydelsefullt i sjukdomsprocessen.

Aim: To examine patients’ experiences of the quality of life in newly-diagnosed type 2 Diabetes Mellitus. Method: An empirical study with a qualitative approach that included ten participants with newly diagnosed type 2 Diabetes Mellitus. Semi-structured interviews were conducted on the basis of an interview-guide and the collected data was analyzed using qualitative manifest content analysis. Results: The study resulted in four main categories and ten subcategories. The experience of receiving a diagnosis varied between the participants, some participants did not experience the news as surprising, while others experienced feelings of shock and denial. The participants experienced positive changes, for example weight loss and improved health but also negative changes, such as being dependent of medicine. Some participants experienced no change at all. Type 2 Diabetes Mellitus did not affect the participants’ physical and mental health. The participants considered it important to get support from both surrounding people and health care. Conclusion: The feelings of a diagnosis could vary but the experience of quality of life is not affected by Type 2 Diabetes Mellitus in most cases in the study. The patient's attitude to living with Type 2 Diabetes Mellitus affects the ability to perform self-care, and the district nurse support and involvement is considered to be important in the process of the disease.

Subjects/Keywords: District nurse; Experience; Type 2 Diabetes Mellitus; Qualitative; Quality of life.; Distriktsköterska; Kvalitativ; Livskvalité; Typ 2 Diabetes Mellitus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Karlsson, C. (2015). Patienters upplevelser av livskvalitet vid nydiagnostiserad typ 2 Diabetes Mellitus : En intervjustudie. (Thesis). Dalarna University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:du-20900

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Karlsson, Carolina. “Patienters upplevelser av livskvalitet vid nydiagnostiserad typ 2 Diabetes Mellitus : En intervjustudie.” 2015. Thesis, Dalarna University. Accessed January 18, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:du-20900.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Karlsson, Carolina. “Patienters upplevelser av livskvalitet vid nydiagnostiserad typ 2 Diabetes Mellitus : En intervjustudie.” 2015. Web. 18 Jan 2021.

Vancouver:

Karlsson C. Patienters upplevelser av livskvalitet vid nydiagnostiserad typ 2 Diabetes Mellitus : En intervjustudie. [Internet] [Thesis]. Dalarna University; 2015. [cited 2021 Jan 18]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:du-20900.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Karlsson C. Patienters upplevelser av livskvalitet vid nydiagnostiserad typ 2 Diabetes Mellitus : En intervjustudie. [Thesis]. Dalarna University; 2015. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:du-20900

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

18. Wu, Kai-Di. Association studies of visfatin concentration and gene polymorphism in type 2 diabetes mellitus with and without macrovascular complications.

Degree: Master, Biological Sciences, 2008, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0120108-152648

► Adiposity has been shown to secrete bioactive cytokines and growth factor known as adipocytokines, they can contribute to obesity, diabetes and complications of diabetes. Visfatin… (more)

▼ Adiposity has been shown to secrete bioactive cytokines and growth factor known as adipocytokines, they can contribute to obesity, diabetes and complications of diabetes. Visfatin is a novel adipocytokine, and it was shown to exert insulin-mimetic effects in stimulating glucose transport and induced triglyceride accumulation in preadipocytes and triglyceride synthesis from gluvose. Visfatin plasma levels are increased in morbid obesity and type 2 diabetes mellitus. These finding indicate that visfatin may play a role in the association between visceral obesity and increased metabolic risk, visfatin gene suggested that genetic variation in the visfatin gene may, indeed, have a minor effect on visceral and subcutaneous visfatin messenger RNA expression profiles and parameters of glucose and insulin metabolism. In this study, we explored the relationships between the plasma level of visfatin and genetic single nucleotide polymorphisms (SNPs) of visfatin gene in type 2 diabetes mellitus (T2DM) with and without macrovascular disease. Plasma visfatin was found to be elevated significantly in T2DM with macrovascular disease patients. Moreover, waist to hip ratio was independently associated with plasma visfatin level. There were statistically significant differences in visfatin -948 G/T genetic variants distribution between T2DM with macrovascular disease and the T2DM control group. The visfatin -948 G/T heterozygotes showed higher mean high-density lipoprotein cholesterol than the carriers of the G allele. The results of the current study indicated that plasma visfatin levels were associated with macrovascular complications in type 2 diabetes. However, the definite roles of visfatin in the pathogenesis of insulin resistance, glucose and lipid metabolism are unclear. The observation of changes in the plasma concentrations of visfatin seen in T2DM and T2DM with macrovascular diseases may exert beneficial effects in understanding roles of visfatin in physiologic activity and metabolic disorder. Further studies are needed to elucidate the mechanisms behind visfatin overexpression in humans. Advisors/Committee Members: Ching-Mei Hsu (chair), Chung-Lung Cho (committee member), Hsueh-Wen Chang (chair).

Subjects/Keywords: visfatin; type 2 diabetes mellitus; macrovascular complications

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wu, K. (2008). Association studies of visfatin concentration and gene polymorphism in type 2 diabetes mellitus with and without macrovascular complications. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0120108-152648

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wu, Kai-Di. “Association studies of visfatin concentration and gene polymorphism in type 2 diabetes mellitus with and without macrovascular complications.” 2008. Thesis, NSYSU. Accessed January 18, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0120108-152648.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wu, Kai-Di. “Association studies of visfatin concentration and gene polymorphism in type 2 diabetes mellitus with and without macrovascular complications.” 2008. Web. 18 Jan 2021.

Vancouver:

Wu K. Association studies of visfatin concentration and gene polymorphism in type 2 diabetes mellitus with and without macrovascular complications. [Internet] [Thesis]. NSYSU; 2008. [cited 2021 Jan 18]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0120108-152648.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wu K. Association studies of visfatin concentration and gene polymorphism in type 2 diabetes mellitus with and without macrovascular complications. [Thesis]. NSYSU; 2008. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0120108-152648

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Anna University

19. Jyothi kumara P. Investigation of alteration in insulin signaling due to prolonged hyperinsulinemia on 3T3 L1 adipocytes;.

Degree: Investigation of alteration in insulin signaling due to prolonged hyperinsulinemia on 3T3 L1 adipocytes, 2015, Anna University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/34134

►

Type 2 diabetes mellitus T2DM is reaching epidemic proportions newlineworldwide with an increasing percentage of the adult population being affected newlineThe pathogenesis of T2DM results… (more)

Subjects/Keywords: Chronic hyperinsulinemia; Type 2 diabetes mellitus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

P, J. k. (2015). Investigation of alteration in insulin signaling due to prolonged hyperinsulinemia on 3T3 L1 adipocytes;. (Thesis). Anna University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/34134

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

P, Jyothi kumara. “Investigation of alteration in insulin signaling due to prolonged hyperinsulinemia on 3T3 L1 adipocytes;.” 2015. Thesis, Anna University. Accessed January 18, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/34134.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

P, Jyothi kumara. “Investigation of alteration in insulin signaling due to prolonged hyperinsulinemia on 3T3 L1 adipocytes;.” 2015. Web. 18 Jan 2021.

Vancouver:

P Jk. Investigation of alteration in insulin signaling due to prolonged hyperinsulinemia on 3T3 L1 adipocytes;. [Internet] [Thesis]. Anna University; 2015. [cited 2021 Jan 18]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/34134.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

P Jk. Investigation of alteration in insulin signaling due to prolonged hyperinsulinemia on 3T3 L1 adipocytes;. [Thesis]. Anna University; 2015. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/34134

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Addis Ababa University

20. ALEMSEGED, AYELE. APPROPRIATENESS OF TYPE 2 DIABETES MELLITUS DRUG THERAPY: A CASE OF TIKUR ANBESSA SPECIALIZED HOSPITAL DIABETES CLINIC .

Degree: 2014, Addis Ababa University

URL: http://etd.aau.edu.et/dspace/handle/123456789/6070

► Appropriateness of Type 2 diabetes mellitus drug therapy: A case of Tikur Anbessa Specialized Hospital Diabetes Clinic ALEMSEGED AYELE ASFAW ADDIS ABABA UNIVERSITY, 2014 Background:… (more)

▼ Appropriateness of Type 2 diabetes mellitus drug therapy: A case of Tikur Anbessa Specialized Hospital Diabetes Clinic ALEMSEGED AYELE ASFAW ADDIS ABABA UNIVERSITY, 2014 Background: Diabetes mellitus (DM) is a metabolic problem involving chronically high blood glucose levels or hyperglycemia, which is thought to arise from insulin deficiency. This insulin deficiency can be decrease in amount or a complete absence in body. In the long run high blood glucose level could lead to various complications. Beside altered glucose metabolism carbohydrate, protein, and lipids metabolisms are also affected in diabetes mellitus. Objective: To assess appropriateness of Type 2 diabetes mellitus drug therapy (T2DM) and investigate association between fasting blood glucose (FBG) and the patients’ clinical and demographic characteristics at the diabetes clinic of Tikur Anbessa specialized hospital (TASH). Methods: The study was a cross sectional hospital based survey and used both quantitative and qualitative methods. T2DM patients who came for their follow up treatment at the diabetes clinic of TASH over a one month period (April 2013) were used as research participants. Plus key informant interview with the help of semi-structured open ended questioner was used focusing on the experience and practice physicians within the diabetes clinic regarding medication choice and guidelines they use. Results: A total of 103 patients enrolled in the survey and the proportion of females (59.2%) was higher than males (40.8%). The mean age was 52.2 years and most of them live in Addis Ababa. When it comes to clinical characteristics mean FBG was 155.99 ± 44.32 mg/dl, the difference in FBG between male and female was insignificant (P=0.325). Body mass index (BMI) had a mean value of 26.4± 3.05 kg/m2 and 51.45% of the patients were overweight. Medication wise NPH (56.3%), metformin plus glibenclamide (19.4%) and metformin (10.7%) were the most prescribed drug therapies. And 3.88% of patients were only on glibenclamide. The association of gender, age, BMI and medication used with the FBG levels of patients was not significant with a p value of 0.6, 0.803, 0.97 and 0.081 respectively. The key informants point out that patient load, physician rotation, lack of guide-line and devices as a reason for inadequacy of treatment. Conclusions: The treatment of T2DM is appropriate with existing problems. Metformin was the first choice oral medication, while most patients were on NPH. And no single factor was associated with influencing the FBG of patients. Key Words: Type 2 diabetes mellitus, Drug therapy Advisors/Committee Members: Epherm Engidawork(Dr.) (advisor).

Subjects/Keywords: Type 2 diabetes mellitus; Drug therapy

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APA (6^th Edition):

ALEMSEGED, A. (2014). APPROPRIATENESS OF TYPE 2 DIABETES MELLITUS DRUG THERAPY: A CASE OF TIKUR ANBESSA SPECIALIZED HOSPITAL DIABETES CLINIC . (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/6070

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

ALEMSEGED, AYELE. “APPROPRIATENESS OF TYPE 2 DIABETES MELLITUS DRUG THERAPY: A CASE OF TIKUR ANBESSA SPECIALIZED HOSPITAL DIABETES CLINIC .” 2014. Thesis, Addis Ababa University. Accessed January 18, 2021. http://etd.aau.edu.et/dspace/handle/123456789/6070.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

ALEMSEGED, AYELE. “APPROPRIATENESS OF TYPE 2 DIABETES MELLITUS DRUG THERAPY: A CASE OF TIKUR ANBESSA SPECIALIZED HOSPITAL DIABETES CLINIC .” 2014. Web. 18 Jan 2021.

Vancouver:

ALEMSEGED A. APPROPRIATENESS OF TYPE 2 DIABETES MELLITUS DRUG THERAPY: A CASE OF TIKUR ANBESSA SPECIALIZED HOSPITAL DIABETES CLINIC . [Internet] [Thesis]. Addis Ababa University; 2014. [cited 2021 Jan 18]. Available from: http://etd.aau.edu.et/dspace/handle/123456789/6070.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

ALEMSEGED A. APPROPRIATENESS OF TYPE 2 DIABETES MELLITUS DRUG THERAPY: A CASE OF TIKUR ANBESSA SPECIALIZED HOSPITAL DIABETES CLINIC . [Thesis]. Addis Ababa University; 2014. Available from: http://etd.aau.edu.et/dspace/handle/123456789/6070

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. Romero, Félix. Effects of a physical activity and dietary education intervention in a population with type 2 diabetes mellitus.

Degree: 2010, Universidad de Lleida; Instituto Politécnico de Santarém

URL: http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ipsantarem.pt:10400.15/383

►

Tese de doutoramento apresentada por,Félix Luís de Lima e Cunha Hopffer Romero,á Universidade de Lleida, orientada por Director: Pedro Manuel Marques Vidal PhD

Background: Type… (more)

▼

Tese de doutoramento apresentada por,Félix Luís de Lima e Cunha Hopffer Romero,á Universidade de Lleida, orientada por Director: Pedro Manuel Marques Vidal PhD

Background: Type 2 Diabetes is becoming increasingly prevalent worldwide at an alarming rate. Physical activity and adequate dietary patterns are cornerstones for the treatment and prevention of diabetes. Lifestyle intervention programs can be effective, but their application to the elderly needs further study. Methods: overall, 43 individuals with diagnosed type 2 diabetes were assigned to control (12 men, 12 women; age 68.9 ± 11.3, range 46- 84 years) or intervention (6 men 13 women; age 69.5 ± 8.9, range 52- 81 years) groups based on their own choice. The intervention group received a lifestyle program including physical activity classes and dietary counseling for a 9 month period. The control group received the usual care. Improvement in physical activity and dietary patterns was assessed as well as changes in biological (weight, body composition, blood pressure, lipid profile, HbA1c, glycemia), fitness (strength, aerobic endurance, flexibility, agility), psychological (profile of mood states) and economic variables (individual and state cost of medications). Results: participants in the intervention group tended to increase their overall physical activity (p=0.020) and to adopt better dietary patterns (p=0.050). However changes in lifestyle were mild: changes in overall physical activity outside the program were non-significant and no significant changes were found in the percentage of compliers with the dietary recommendations for the Portuguese population. Significant changes were found in lower limb strength (p=0.014), upper limb strength (p=0.001), aerobic endurance (p=0.001) and upper limb flexibility (p=0.040). Conversely no significant changes were found for body composition, blood pressure, lipid profile or glycemic control. The profile of mood states showed a significant decrease in the Fatigue-Inertia factor (p=0.002). The cost of medication increased substantially for the State (p=0.028) but not for individuals. Conclusions: The program achieved moderate success in relation to behaviour change, but not enough to have a significant impact on most clinical and biological variables. Fitness was improved and perceived fatigue reduced. Our results suggest that in order to be more effective, intervention should begin as early as possible, as its implementation among elderly subjects is difficult. This would lead to a larger response to the program and to a more intense physical activity intervention.Antecedentes: la diabetes tipo 2 es cada vez más frecuente en la población general. La actividad física adecuada y los hábitos alimentarios son las piedras angulares para el tratamiento de la diabetes y por lo tanto los programas de intervención de mejora del estilo de vida pueden ser de valor, pero el impacto de estos programas necesita más estudio. Métodos: 43 personas diagnosticadas con diabetes tipo 2 fueron asignadas a un grupo de control (12…

Subjects/Keywords: Physical; Activity; Dietary; Type 2 Diabetes Mellitus

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APA (6^th Edition):

Romero, F. (2010). Effects of a physical activity and dietary education intervention in a population with type 2 diabetes mellitus. (Thesis). Universidad de Lleida; Instituto Politécnico de Santarém. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ipsantarem.pt:10400.15/383

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Romero, Félix. “Effects of a physical activity and dietary education intervention in a population with type 2 diabetes mellitus.” 2010. Thesis, Universidad de Lleida; Instituto Politécnico de Santarém. Accessed January 18, 2021. http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ipsantarem.pt:10400.15/383.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Romero, Félix. “Effects of a physical activity and dietary education intervention in a population with type 2 diabetes mellitus.” 2010. Web. 18 Jan 2021.

Vancouver:

Romero F. Effects of a physical activity and dietary education intervention in a population with type 2 diabetes mellitus. [Internet] [Thesis]. Universidad de Lleida; Instituto Politécnico de Santarém; 2010. [cited 2021 Jan 18]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ipsantarem.pt:10400.15/383.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Romero F. Effects of a physical activity and dietary education intervention in a population with type 2 diabetes mellitus. [Thesis]. Universidad de Lleida; Instituto Politécnico de Santarém; 2010. Available from: http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ipsantarem.pt:10400.15/383

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Waikato

22. Hall, Luke. A Model In Vitro System to Study Heat Shock Protein 60 (HSP60) Expression in Response to Mitochondrial Impairment in Human Cells .

Degree: 2013, University of Waikato

URL: http://hdl.handle.net/10289/7905

► Heat Shock Proteins (HSPs) are a class of ubiquitously expressed and functionally related proteins found in all living organisms from humans to bacteria. Their expression… (more)

▼ Heat Shock Proteins (HSPs) are a class of ubiquitously expressed and functionally related proteins found in all living organisms from humans to bacteria. Their expression is increased in response to various cellular stressors in what is referred to as the heat shock response. The induction of one particular HSP, HSP60, has been found to be correlated with mitochondria specific cell stress. Recently HSP60 has been found to be secreted and expressed extracellularly, after first being thought to be strictly intracellular. However, the mechanisms of these mechanisms of translocation and secretion have not been clearly identified. The aim of this study was to develop a model in vitro system for HSP60 expression in human cells so that treatments which resulted in mitochondrial impairment could be investigated. This study looked at several aspects of high glucose, hydrogen peroxide (H₂O₂), and sodium azide treatment on human HeLa cells. At low levels, each treatment had a hormetic effect on HeLa cell growth; however at high concentrations growth was significantly inhibited. Additionally, high treatment concentrations resulted in increased cell lysis as determined by LDH assays. Treatment with concentrations of 100mM glucose, 200μM H₂O₂, and 50μM sodium azide were the only treatment concentrations that did not result in significantly different levels of cell lysis when compared to a control sample. Mitochondrial dehydrogenase activity was also found to be significantly decreased at high treatment concentrations as determined by MTT assays. Thus, 100mM glucose, 200μM H₂O₂, and 50μM sodium azide treatments were identified as optimal conditions for mitochondrial targeted cell stress, as each of these treatments impaired cell growth and inhibited mitochondrial activity while having no significant effect on the degree of cell lysis. The 100mM glucose, 200μM H₂O₂, and 50μM sodium azide treatments were then investigated for the intracellular reactive oxygen species (ROS) activity they induced over treatment periods of 24 hours, 3 and 7 days. After 7 days of treatment, the 200μM H₂O₂ and 50μM sodium azide treatments resulted in an approximate three-fold increase in ROS activity, while the 100mM glucose treatment resulted in almost twice as much ROS compared to a control sample. Finally, the effects of 100mM glucose, 200μM H₂O₂, and 50μM sodium azide treatments on HSP60 and HSP70 expression was also examined over 3 and 7 day time periods. After the 7 day treatment period, the 100mM glucose treatment had induced a 2.43 fold increase in HSP60 expression and a 2.75 fold increase in HSP70 expression, the 200μM H₂O₂ induced a 3.48 fold increase in HSP60 expression and a 3.98 fold increase in HSP70 expression, and finally the 50μM sodium azide induced a 4.74 fold increase in HSP60 expression and a 5.08 fold increase in HSP70 expression. It can therefore be concluded that 100mM glucose, 200μM H₂O₂, and 50μM sodium azide results in the upregulation of HSP60 and HSP70 in human HeLa cells. Therefore this model may be used to… Advisors/Committee Members: Martinus, Ryan Dennis (advisor).

Subjects/Keywords: HSP60; Stress; Type 2 Diabetes Mellitus; Mitochondria

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APA (6^th Edition):

Hall, L. (2013). A Model In Vitro System to Study Heat Shock Protein 60 (HSP60) Expression in Response to Mitochondrial Impairment in Human Cells . (Masters Thesis). University of Waikato. Retrieved from http://hdl.handle.net/10289/7905

Chicago Manual of Style (16^th Edition):

Hall, Luke. “A Model In Vitro System to Study Heat Shock Protein 60 (HSP60) Expression in Response to Mitochondrial Impairment in Human Cells .” 2013. Masters Thesis, University of Waikato. Accessed January 18, 2021. http://hdl.handle.net/10289/7905.

MLA Handbook (7^th Edition):

Hall, Luke. “A Model In Vitro System to Study Heat Shock Protein 60 (HSP60) Expression in Response to Mitochondrial Impairment in Human Cells .” 2013. Web. 18 Jan 2021.

Vancouver:

Hall L. A Model In Vitro System to Study Heat Shock Protein 60 (HSP60) Expression in Response to Mitochondrial Impairment in Human Cells . [Internet] [Masters thesis]. University of Waikato; 2013. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10289/7905.

Council of Science Editors:

Hall L. A Model In Vitro System to Study Heat Shock Protein 60 (HSP60) Expression in Response to Mitochondrial Impairment in Human Cells . [Masters Thesis]. University of Waikato; 2013. Available from: http://hdl.handle.net/10289/7905

University of Texas Southwestern Medical Center

23. Anderson, Jason Graham. SIRT6 Overexpression Protects Against Diet-Induced Diabetes in Mice.

Degree: 2013, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/1724

► Numerous studies in a variety of species indicate that caloric restriction (CR) elicits beneficial metabolic effects including reduced adiposity and improved glucose homeostasis, as well… (more)

▼ Numerous studies in a variety of species indicate that caloric restriction (CR) elicits beneficial metabolic effects including reduced adiposity and improved glucose homeostasis, as well as enhanced insulin and leptin sensitivity. Conversely, chronic feeding on high caloric diets brings about opposite outcomes and can progress to type-II-diabetes and obesity. An intense effort by many researchers has begun to elucidate the homeostatic mechanisms accounting for these beneficial metabolic effects of CR in order to facilitate development of CR-mimetic drugs to combat the alarming increase of these diseases. Mounting experimental evidence suggests that Sirtuins may be principal mediators of the metabolic effects of CR (1). Sirtuins are believed to sense and respond to cellular energy deficit via their (NAD+)-dependent enzymatic activities including lysine deacetylation of a variety of cytosolic, mitochondrial and nuclear proteins (2). Initial studies involving SIRT6, one of three nuclear sirtuins, suggest that it may be an attractive drug target for obesity and type-II-diabetes therapy. Knockout studies indicate that SIRT6 is required for normal growth, adiposity, and glucose homeostasis (3). Yet, contrasting these Sirt6-null phenotypes with those from opposing SIRT6 gain-of-function animal models lead to incongruous and seemingly contradictory conclusions regarding the stress-responsive homeostatic functions of SIRT6, casting doubt as to whether SIRT6 agonist or antagonist drugs should be sought after. To address these issues, I generated genetically engineered mice (Sirt6BAC mice) designed to eutopically overexpress SIRT6 and mimic its moderate eutopic upregulation observed during CR. This was achieved via BAC- mediated genomic insertion of an isogenic 187kb DNA region from chromosome 10 of mus musculus encompassing Sirt6. These Sirt6BAC mutants fed a high caloric diet exhibit improved glucose homeostasis as indicated via intraperitoneal glucose tolerance tests and intraperitoneal pyruvate tolerance tests. Hyperinsulinemic/euglycemic clamp indicate that these mutants exhibit enhanced insulin-sensitive inhibition of endogenous glucose production as well as enhanced blood glucose disposal and uptake into gastrocnemius and soleus muscle. Importantly, these data suggest that SIRT6 agonist drugs may be worthy of translational research for the treatment of type-II diabetes in humans. Advisors/Committee Members: Scherer, Philipp, Elmquist, Joel, Coppari, Roberto, Elias, Carol, Kuro-O, Makoto.

Subjects/Keywords: Diabetes Mellitus, Type 2; Glucose; Obesity; Sirtuins

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APA (6^th Edition):

Anderson, J. G. (2013). SIRT6 Overexpression Protects Against Diet-Induced Diabetes in Mice. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/1724

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Anderson, Jason Graham. “SIRT6 Overexpression Protects Against Diet-Induced Diabetes in Mice.” 2013. Thesis, University of Texas Southwestern Medical Center. Accessed January 18, 2021. http://hdl.handle.net/2152.5/1724.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Anderson, Jason Graham. “SIRT6 Overexpression Protects Against Diet-Induced Diabetes in Mice.” 2013. Web. 18 Jan 2021.

Vancouver:

Anderson JG. SIRT6 Overexpression Protects Against Diet-Induced Diabetes in Mice. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2013. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2152.5/1724.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Anderson JG. SIRT6 Overexpression Protects Against Diet-Induced Diabetes in Mice. [Thesis]. University of Texas Southwestern Medical Center; 2013. Available from: http://hdl.handle.net/2152.5/1724

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Universiteit Nederland

24. Struik-Vink, Hélène. Denken is Doen? De cognitieve representatie van ziekte als determinant van zelfmanagementgedrag bij Nederlandse, Turkse en Marokkaanse patiënten met diabetes mellitus type 2 in de huisartsenpraktijk .

Degree: 2011, Open Universiteit Nederland

URL: http://hdl.handle.net/1820/3282

► Diabetes komt vaker voor bij Turken en Marokkanen in Nederland dan bij autochtone Nederlanders. Effectieve behandeling van diabetes bestaat vooral uit het aanleren van goed… (more)

Subjects/Keywords: Diabetes mellitus type 2; cognitieve representatie; zelfmanagementgedrag

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APA (6^th Edition):

Struik-Vink, H. (2011). Denken is Doen? De cognitieve representatie van ziekte als determinant van zelfmanagementgedrag bij Nederlandse, Turkse en Marokkaanse patiënten met diabetes mellitus type 2 in de huisartsenpraktijk . (Masters Thesis). Open Universiteit Nederland. Retrieved from http://hdl.handle.net/1820/3282

Chicago Manual of Style (16^th Edition):

Struik-Vink, Hélène. “Denken is Doen? De cognitieve representatie van ziekte als determinant van zelfmanagementgedrag bij Nederlandse, Turkse en Marokkaanse patiënten met diabetes mellitus type 2 in de huisartsenpraktijk .” 2011. Masters Thesis, Open Universiteit Nederland. Accessed January 18, 2021. http://hdl.handle.net/1820/3282.

MLA Handbook (7^th Edition):

Struik-Vink, Hélène. “Denken is Doen? De cognitieve representatie van ziekte als determinant van zelfmanagementgedrag bij Nederlandse, Turkse en Marokkaanse patiënten met diabetes mellitus type 2 in de huisartsenpraktijk .” 2011. Web. 18 Jan 2021.

Vancouver:

Struik-Vink H. Denken is Doen? De cognitieve representatie van ziekte als determinant van zelfmanagementgedrag bij Nederlandse, Turkse en Marokkaanse patiënten met diabetes mellitus type 2 in de huisartsenpraktijk . [Internet] [Masters thesis]. Open Universiteit Nederland; 2011. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1820/3282.

Council of Science Editors:

Struik-Vink H. Denken is Doen? De cognitieve representatie van ziekte als determinant van zelfmanagementgedrag bij Nederlandse, Turkse en Marokkaanse patiënten met diabetes mellitus type 2 in de huisartsenpraktijk . [Masters Thesis]. Open Universiteit Nederland; 2011. Available from: http://hdl.handle.net/1820/3282

University of Ghana

25. Amoah, A. The Use of Complementary and Alternative Medicine among Patients Diagnosed with Type 2 Diabetes Mellitus at Lekma Hospital .

Degree: 2018, University of Ghana

URL: http://ugspace.ug.edu.gh/handle/123456789/32240

► The use of complementary and alternative medicine for the management of type 2 diabetes mellitus stems from the experiences, beliefs, and its efficacy. This study… (more)

Subjects/Keywords: Medicine; Type 2 Diabetes; Mellitus; Lekma Hospital

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APA (6^th Edition):

Amoah, A. (2018). The Use of Complementary and Alternative Medicine among Patients Diagnosed with Type 2 Diabetes Mellitus at Lekma Hospital . (Masters Thesis). University of Ghana. Retrieved from http://ugspace.ug.edu.gh/handle/123456789/32240

Chicago Manual of Style (16^th Edition):

Amoah, A. “The Use of Complementary and Alternative Medicine among Patients Diagnosed with Type 2 Diabetes Mellitus at Lekma Hospital .” 2018. Masters Thesis, University of Ghana. Accessed January 18, 2021. http://ugspace.ug.edu.gh/handle/123456789/32240.

MLA Handbook (7^th Edition):

Amoah, A. “The Use of Complementary and Alternative Medicine among Patients Diagnosed with Type 2 Diabetes Mellitus at Lekma Hospital .” 2018. Web. 18 Jan 2021.

Vancouver:

Amoah A. The Use of Complementary and Alternative Medicine among Patients Diagnosed with Type 2 Diabetes Mellitus at Lekma Hospital . [Internet] [Masters thesis]. University of Ghana; 2018. [cited 2021 Jan 18]. Available from: http://ugspace.ug.edu.gh/handle/123456789/32240.

Council of Science Editors:

Amoah A. The Use of Complementary and Alternative Medicine among Patients Diagnosed with Type 2 Diabetes Mellitus at Lekma Hospital . [Masters Thesis]. University of Ghana; 2018. Available from: http://ugspace.ug.edu.gh/handle/123456789/32240

Virginia Tech

26. Donnelly, Sarah Rebecca. Temporal examination of DNA methylation profile reprogramming in the promoter region of PGC-1α during the progression of insulin resistance and type 2 diabetes mellitus in rodent models.

Degree: PhD, Human Nutrition, Foods, and Exercise, 2019, Virginia Tech

URL: http://hdl.handle.net/10919/92592

► High blood glucose, referred to as type 2 diabetes (T2DM), increases the risk for heart and kidney disease, blindness, stroke, and death. Efforts to prevent… (more)

Subjects/Keywords: type 2 diabetes mellitus; epigenetics; mitochondria; methylation

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APA (6^th Edition):

Donnelly, S. R. (2019). Temporal examination of DNA methylation profile reprogramming in the promoter region of PGC-1α during the progression of insulin resistance and type 2 diabetes mellitus in rodent models. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/92592

Chicago Manual of Style (16^th Edition):

Donnelly, Sarah Rebecca. “Temporal examination of DNA methylation profile reprogramming in the promoter region of PGC-1α during the progression of insulin resistance and type 2 diabetes mellitus in rodent models.” 2019. Doctoral Dissertation, Virginia Tech. Accessed January 18, 2021. http://hdl.handle.net/10919/92592.

MLA Handbook (7^th Edition):

Donnelly, Sarah Rebecca. “Temporal examination of DNA methylation profile reprogramming in the promoter region of PGC-1α during the progression of insulin resistance and type 2 diabetes mellitus in rodent models.” 2019. Web. 18 Jan 2021.

Vancouver:

Donnelly SR. Temporal examination of DNA methylation profile reprogramming in the promoter region of PGC-1α during the progression of insulin resistance and type 2 diabetes mellitus in rodent models. [Internet] [Doctoral dissertation]. Virginia Tech; 2019. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10919/92592.

Council of Science Editors:

Donnelly SR. Temporal examination of DNA methylation profile reprogramming in the promoter region of PGC-1α during the progression of insulin resistance and type 2 diabetes mellitus in rodent models. [Doctoral Dissertation]. Virginia Tech; 2019. Available from: http://hdl.handle.net/10919/92592

University of Newcastle

27. Aguiar, Elroy Joseph. The feasibility and efficacy of the type 2 diabetes PULSE (Prevention Using LifeStyle Education) randomised controlled trial: a self-administered, gender-tailored, multi-component lifestyle intervention for men at high-risk for type 2 diabetes.

Degree: PhD, 2015, University of Newcastle

URL: http://hdl.handle.net/1959.13/1309784

►

Research Doctorate - Doctor of Philosophy (PhD)

The rising prevalence of type 2 diabetes mellitus (T2DM) is a global health concern. Seminal trials have demonstrated… (more)

▼

Research Doctorate - Doctor of Philosophy (PhD)

The rising prevalence of type 2 diabetes mellitus (T2DM) is a global health concern. Seminal trials have demonstrated the strong efficacy of lifestyle intervention for T2DM prevention, however several evidence gaps have been identified in the existing T2DM prevention literature, namely, a lack of lifestyle interventions that: i) are pragmatic and scalable, ii) are gender-targeted for men, and iii) utilise a multi-component approach combing diet modification, aerobic exercise and resistance training. Thus, the central component of this thesis was the development and evaluation of the PULSE (Prevention Using LifeStyle Education) Program, a 6-month, self-administered, gender-tailored, multi-component lifestyle intervention for men at high-risk for developing T2DM. The primary aim was to evaluate the feasibility and efficacy of the PULSE Program for improving a range of risk factors strongly linked with T2DM development, including weight (primary outcome) and glycaemic markers. This thesis is presented as a series of manuscripts that address the primary and three secondary aims related to the development and evaluation of the PULSE Program. Secondary aims 1 and 2 are presented first as they provide the context for the main analysis of this thesis. Secondary Aim 1: To systematically review and meta-analyse the current evidence regarding multi-component lifestyle interventions (diet, aerobic exercise and resistance training) for type 2 diabetes mellitus prevention in adults at high-risk or with prediabetes. A systematic review was conducted to synthesise the evidence from T2DM prevention lifestyle interventions employing a multi-component lifestyle approach. In total 23 articles arising from 8 trials met the eligibility criteria. Methodological quality was mixed, with four of the eight trials classified with a high risk of bias. Meta-analysis favoured interventions over controls for weight loss (-3.79 kg [-6.13, -1.46; 95% CI], Z = 3.19, P = 0.001) and fasting plasma glucose (-0.13 mmol.L⁻¹ [-0.24, -0.02; 95% CI], Z = 2.42, P = 0.02). The results of this systematic review support a multi-component approach for T2DM prevention. Secondary Aim 2: To describe the characteristics of men identified at high-risk for developing type 2 diabetes mellitus using the Australian Diabetes Risk Assessment (AUSDRISK) tool, and determine the ability of the tool to identify men with prediabetes and metabolic syndrome. An analysis of the characteristics of men (n = 101) identified as at high-risk for developing T2DM (AUSDRISK score ≥ 12) was performed to evaluate the performance of the AUSDRISK tool. In total, 70% of men displayed elevations for FPG or HbA_1C in the prediabetes range. Further, 62% were classified with metabolic syndrome. This study demonstrated the good ability of the AUSDRISK tool to identify men with substantial risk for the development of T2DM. Primary Aim: to evaluate the feasibility and efficacy of the PULSE Program for improving a range of risk factors…

Advisors/Committee Members: University of Newcastle. Faculty of Health & Medicine, School of Biomedical Sciences and Pharmacy.

Subjects/Keywords: type 2 diabetes mellitus; diet; physical activity; obesity; overweight; weight loss; diabetes prevention; thesis by publication

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APA (6^th Edition):

Aguiar, E. J. (2015). The feasibility and efficacy of the type 2 diabetes PULSE (Prevention Using LifeStyle Education) randomised controlled trial: a self-administered, gender-tailored, multi-component lifestyle intervention for men at high-risk for type 2 diabetes. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1309784

Chicago Manual of Style (16^th Edition):

Aguiar, Elroy Joseph. “The feasibility and efficacy of the type 2 diabetes PULSE (Prevention Using LifeStyle Education) randomised controlled trial: a self-administered, gender-tailored, multi-component lifestyle intervention for men at high-risk for type 2 diabetes.” 2015. Doctoral Dissertation, University of Newcastle. Accessed January 18, 2021. http://hdl.handle.net/1959.13/1309784.

MLA Handbook (7^th Edition):

Aguiar, Elroy Joseph. “The feasibility and efficacy of the type 2 diabetes PULSE (Prevention Using LifeStyle Education) randomised controlled trial: a self-administered, gender-tailored, multi-component lifestyle intervention for men at high-risk for type 2 diabetes.” 2015. Web. 18 Jan 2021.

Vancouver:

Aguiar EJ. The feasibility and efficacy of the type 2 diabetes PULSE (Prevention Using LifeStyle Education) randomised controlled trial: a self-administered, gender-tailored, multi-component lifestyle intervention for men at high-risk for type 2 diabetes. [Internet] [Doctoral dissertation]. University of Newcastle; 2015. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1959.13/1309784.

Council of Science Editors:

Aguiar EJ. The feasibility and efficacy of the type 2 diabetes PULSE (Prevention Using LifeStyle Education) randomised controlled trial: a self-administered, gender-tailored, multi-component lifestyle intervention for men at high-risk for type 2 diabetes. [Doctoral Dissertation]. University of Newcastle; 2015. Available from: http://hdl.handle.net/1959.13/1309784

28. Γραμματικού, Σοφία. Πρόληψη του σακχαρώδους διαβήτη τύπου 2 με υγιεινοδιαιτητική παρέμβαση σε ελληνικό πληθυσμό υψηλού κινδύνου.

Degree: 2013, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/29642

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Backgroud: It is known that the prevalence and incidence of diabetes mellitus type 2 (DM2)is increasing worldwide in all age groups due to increasing obesity… (more)

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Backgroud: It is known that the prevalence and incidence of diabetes mellitus type 2 (DM2)is increasing worldwide in all age groups due to increasing obesity and sedentary lifestylesadopted. Prevention of DM2 is an issue for health services because of high cost, which isassociated with the treatment and its complications. The US Diabetes Prevention Programme(DPP) and the Finnish Diabetes Prevention Study (DPS) showed that DM2 is a disease that ispreventable by lifestyle intervention programme at 58%.Aim: The aim of this study was to detect high-risk individuals and prevent the developmentof Type 2 diabetes mellitus (T2DM) implementing the first community-based lifestyleintervention programme in a general population sample in Athens, as part of the DE-PLANStudy.Methods: The Finnish Type 2 Diabetes Risk Score (FINDRISC) questionnaire wasdistributed to 7900 people at workplaces and primary-care centres in order to determine highriskindividuals. High-risk individuals were invited to receive an oral glucose tolerance test(OGTT) in order to exclude persons with unknown diabetes. Non-diabetic persons wereinvited to participate in a 1-year intervention programme, based on bimonthly sessions with adietitian.Results: Three thousand two hundred and forty questionnaires were returned; 620 high-riskindividuals were identified and 191 agreed to participate. Recruitment from workplaces wasthe most successful strategy for identifying high-risk persons, enrolling and maintaining themthroughout the study. The 125 participants who fully completed the programme (66 did notreturn for a second OGTT) lost on average 1.0 ± 4.7 kg (P = 0.022). Higher adherence to theintervention sessions resulted in more significant weight loss (1.1 ± 4.8 vs. 0.6 ± 4.6 kg forlow adherence). Persons with impaired fasting glucose (IFG) and ⁄ or impaired glucosetolerance (IGT) at baseline lost more weight than those with normal glucose tolerance (1.5 ±4.8 vs. 0.2 ± 4.5 kg). The percentage of people with any type of dysglycaemia (IFG ⁄ IGT)was lower after the intervention (68.0% at baseline vs. 53.6% 1 year later, P = 0.009); 5.6%developed diabetes. Conclusions: The implementation of a lifestyle intervention programme to prevent T2DM inthe community is practical and feasible, accompanied by favourable lifestyle changes.Recruitment from workplaces was the most successful strategy.

Εισαγωγή: Είναι γνωστό ότι ο επιπολασμός και η επίπτωση του σακχαρώδη διαβήτη τύπου 2(ΣΔ2) αυξάνει παγκοσμίως σε όλες τις ομάδες ηλικιών λόγω αύξησης της παχυσαρκίας καιτου καθιστικού τρόπου ζωής που έχει υιοθετηθεί. Η πρόληψη του ΣΔ2 είναι ένα θέμα πουαπασχολεί τις υπηρεσίες υγείας λόγω του υψηλού κόστους του, το οποίο σχετίζεται με τηνθεραπεία του και τις επιπλοκές του. Οι μελέτες Diabetes Prevention Programme (DPP) καιDiabetes Prevention Study (DPS) έδειξαν ότι ο ΣΔ2 είναι μία νόσος που μπορεί ναπροληφθεί με υγιεινοδιαιτητική παρέμβαση σε ποσοστό 58%.Σκοπός: Σκοπός της παρούσας μελέτης ήταν η ανίχνευση των άτομων υψηλού κινδύνου γιατην εμφάνιση σακχαρώδους διαβήτη τύπου 2 (ΣΔ2)…

Subjects/Keywords: Πρόληψη; Σακχαρώδης διαβήτης τύπου 2; Υγιεινοδιαιτητική παρέμβαση; Αλλαγή τρόπου ζωής; Prevention; Diabetes mellitus type 2; Nutritional intervetion; Life style changes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Γραμματικού, . �. (2013). Πρόληψη του σακχαρώδους διαβήτη τύπου 2 με υγιεινοδιαιτητική παρέμβαση σε ελληνικό πληθυσμό υψηλού κινδύνου. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/29642

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Γραμματικού, Σοφία. “Πρόληψη του σακχαρώδους διαβήτη τύπου 2 με υγιεινοδιαιτητική παρέμβαση σε ελληνικό πληθυσμό υψηλού κινδύνου.” 2013. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed January 18, 2021. http://hdl.handle.net/10442/hedi/29642.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Γραμματικού, Σοφία. “Πρόληψη του σακχαρώδους διαβήτη τύπου 2 με υγιεινοδιαιτητική παρέμβαση σε ελληνικό πληθυσμό υψηλού κινδύνου.” 2013. Web. 18 Jan 2021.

Vancouver:

Γραμματικού �. Πρόληψη του σακχαρώδους διαβήτη τύπου 2 με υγιεινοδιαιτητική παρέμβαση σε ελληνικό πληθυσμό υψηλού κινδύνου. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2013. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10442/hedi/29642.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Γραμματικού �. Πρόληψη του σακχαρώδους διαβήτη τύπου 2 με υγιεινοδιαιτητική παρέμβαση σε ελληνικό πληθυσμό υψηλού κινδύνου. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2013. Available from: http://hdl.handle.net/10442/hedi/29642

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Monteiro, Vanessa dos Santos Cardoso. Enfermagem comunitária : diferentes cenários e desafios para a prestação de cuidados.

Degree: 2010, RCAAP

URL: http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ucp.pt:10400.14/9270

►

Este Relatório descreve os caminhos percorridos no Estágio, no sentido da aquisição de competências na área de especialização em Enfermagem Comunitária. O Estágio desenvolveu-se em… (more)

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Este Relatório descreve os caminhos percorridos no Estágio, no sentido da aquisição de competências na área de especialização em Enfermagem Comunitária. O Estágio desenvolveu-se em dois Módulos (Módulo I - Diagnóstico de Saúde e Módulo II - Intervenção de acordo com as necessidades) que decorreram entre os dias 20 de Abril e 20 de Junho e os dias 6 de Outubro e 27 de Novembro de 2009, respectivamente, no Centro de Saúde Vila Real I. Desenvolveram-se actividades em diferentes domínios da Enfermagem Comunitária, reflectindo a diversidade e multiplicidade de áreas em que foi necessário aprofundar conhecimentos e competências. No âmbito do Módulo I foi produzido um diagnóstico de saúde circunscrito à Adesão/Gestão do Regime Terapêutico e Autovigilância na Diabetes. Foram definidas prioridades, emergindo como área de intervenção a promoção da actividade física nas pessoas com diabetes tipo 2. No segundo módulo, foi concebido um projecto de intervenção (“P’ró Activo: Projecto Educacional para Pessoas com Diabetes Tipo 2”), executado e avaliado, e realizada a I Feira da Diabetes. O projecto “P’ró Activo: Projecto Educacional para Pessoas com Diabetes Tipo 2” procurou promover a escolha informada e o desenvolvimento de habilidades e competências na gestão dos processos de saúde/doença, através de Sessões de Educação para a Saúde, com base na constituição de um grupo operativo. A I Feira da Diabetes visou a promoção de estilos de vida saudáveis, informação relevante para a adesão a comportamentos salutógenicos, rastreio de factores de risco para a diabetes e pé diabético, adesão ao regime terapêutico na diabetes e distribuição de materiais específicos para o auto-cuidado. Foram desenvolvidas outras actividades com vista ao desenvolvimento de diferentes competências na área de actuação da Especialização em Enfermagem Comunitária, nomeadamente no âmbito da Saúde Escolar, Equipa Coordenadora Local da Rede Nacional de Cuidados Continuados Integrados e Medidas de Prevenção da Gripe H1N1, consubstanciadas no Empoderamento Comunitário.

This summary describes the course taken along the traineeship, in order to obtain skills in the area of Specialization in Community Nursing. The traineeship developed in two Units (Module I-Health assessment and Module II- Intervention according needs) that took place between April the 20th and June the 20th 2009, and October the 6th and November the 27th 2009, respectively, in the Vila Real I Health Care Centre. Activities in different fields of the Community Nursing have been developed, reflecting the diversity and multiplicity of areas in which there was a need to deepen knowledge and skills. In the context of Unit I, a health diagnose was made restrict to the Adherence/Management of the Therapeutic Regimen and Self Care in Diabetes. Priorities have been defined, emerging as intervention area the promotion of physical activity in people with Diabetes type 2. In Unit II, an intervention project was conceived (Pro Active: Educational Project for People with diabetes type 2), executed and…

Subjects/Keywords: Enfermagem Comunitária; Diabetes Mellitus Tipo 2; Prevenção; Gestão/Adesão ao Regime Terapêutico; Actividade Física; Community Nursing; Diabetes Mellitus type 2; Prevention; Adherence/Management to the Therapeutic Regimen; Physical Activity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Monteiro, V. d. S. C. (2010). Enfermagem comunitária : diferentes cenários e desafios para a prestação de cuidados. (Thesis). RCAAP. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ucp.pt:10400.14/9270

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Monteiro, Vanessa dos Santos Cardoso. “Enfermagem comunitária : diferentes cenários e desafios para a prestação de cuidados.” 2010. Thesis, RCAAP. Accessed January 18, 2021. http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ucp.pt:10400.14/9270.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Monteiro, Vanessa dos Santos Cardoso. “Enfermagem comunitária : diferentes cenários e desafios para a prestação de cuidados.” 2010. Web. 18 Jan 2021.

Vancouver:

Monteiro VdSC. Enfermagem comunitária : diferentes cenários e desafios para a prestação de cuidados. [Internet] [Thesis]. RCAAP; 2010. [cited 2021 Jan 18]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ucp.pt:10400.14/9270.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Monteiro VdSC. Enfermagem comunitária : diferentes cenários e desafios para a prestação de cuidados. [Thesis]. RCAAP; 2010. Available from: http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ucp.pt:10400.14/9270

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Stellenbosch University

30. Fryer, Bradley James. A community-based lifestyle intervention program for adults with type 2 diabetes mellitus in a low socio-economic status community.

Degree: PhD, Sport Science, 2016, Stellenbosch University

URL: http://hdl.handle.net/10019.1/98537

► ENGLISH ABSTRACT : The prevalence, and associated burden of type-two diabetes mellitus (T2DM), is rapidly increasing globally, and in South Africa, with men and women… (more)

▼ ENGLISH ABSTRACT : The prevalence, and associated burden of type-two diabetes mellitus (T2DM), is rapidly increasing globally, and in South Africa, with men and women of all ages being affected. While there has been an extensive research into the pathophysiological mechanisms, and to some extent, the management of T2DM, healthcare systems are still not able to adequately deal with the increasing number of patients being diagnosed with the disease. Professional- and community-led lifestyle interventions have recently showed the most promise in combating T2DM. There is however, a paucity of data on comprehensive lifestyle interventions in communities of low socio-economic status (SES), where the incidence of T2DM and its related complications is high. The primary aim of this study was to determine the effectiveness of a community-based, 10-week lifestyle intervention on physiological, psychological and health-related outcomes in adults suffering with T2DM in a low SES community. Forty-three participants completed the study (age 59.5 ± 12.2 years, 25 Women; 18 Men), of which 23 made up the experimental group (EXP; BMI: 33.8 ± 7.5; HbA1c: 8.8 ± 2.1) and 20 made up the control group (CON; BMI: 34.4 ± 9.7; HbA1c: 9.4 ± 2.3). The control group completed a pre- and post-testing session, while experimental completed an additional post-testing retention session. The experimental group participated in a 10-week comprehensive lifestyle intervention. A number of anthropometric, cardiovascular and functional measurements were carried out, and questionnaires related to health-related quality of life (HRQoL), social support, dietary habits and lifestyle behaviours, as well as health professional usage were also administered. Following the 10-week comprehensive lifestyle intervention, there was a positive change in the outcome variables measured. There was a statistically significant decrease (p < 0.05) in body fat percentage, diastolic blood pressure and HbA1c, with a statistically significant increase in the total distance walked during the six-minute walk test (6MWT) (p < 0.05). Furthermore, there was a statistically significant improvement (p < 0.05) in all but three of the HRQoL domains. Dietary habits and lifestyle behaviours improved significantly (p < 0.05), with the exception of eating times where there was no change. The frequency at which the participants actively sought professional assistance with the management of their T2DM did not change significantly (p > 0.05). The results from the retention period, obtained 10-weeks after the conclusion of the intervention, suggest that the changes as a result of the program were maintained, however, it is uncertain if those results can be attributed to the use of the post-intervention guide. The findings of this study indicate that a 10-week comprehensive lifestyle intervention is effective in improving physiological, psychological and health-related outcomes in adults with T2DM living in a low SES community. The use of a post-intervention guide as… Advisors/Committee Members: Terblanche, Elmarie, Stellenbosch University. Faculty of Education. Dept. of Sport Science.

Subjects/Keywords: Diabetes mellitus, type 2; Low socioeconomic status and health; Lifestyle intervention – Diabetes; Community-based programmes – Diabetes; Non-insulin-dependent diabetes – Alternative treatment; Diabetes Prevention Program (DPP); UCTD

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fryer, B. J. (2016). A community-based lifestyle intervention program for adults with type 2 diabetes mellitus in a low socio-economic status community. (Doctoral Dissertation). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/98537

Chicago Manual of Style (16^th Edition):

Fryer, Bradley James. “A community-based lifestyle intervention program for adults with type 2 diabetes mellitus in a low socio-economic status community.” 2016. Doctoral Dissertation, Stellenbosch University. Accessed January 18, 2021. http://hdl.handle.net/10019.1/98537.

MLA Handbook (7^th Edition):

Fryer, Bradley James. “A community-based lifestyle intervention program for adults with type 2 diabetes mellitus in a low socio-economic status community.” 2016. Web. 18 Jan 2021.

Vancouver:

Fryer BJ. A community-based lifestyle intervention program for adults with type 2 diabetes mellitus in a low socio-economic status community. [Internet] [Doctoral dissertation]. Stellenbosch University; 2016. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10019.1/98537.

Council of Science Editors:

Fryer BJ. A community-based lifestyle intervention program for adults with type 2 diabetes mellitus in a low socio-economic status community. [Doctoral Dissertation]. Stellenbosch University; 2016. Available from: http://hdl.handle.net/10019.1/98537

Open Access Theses and Dissertations