subject:(Preterm)

1. Vuong, Ann Minh. Prenatal Exposure to Nitrates, Nitrites, and Nitrosatable Drugs and Preterm Births.

Degree: 2013, Texas Digital Library

URL: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66688

► Nitrosatable drugs react with nitrite in the stomach to form N-nitroso compounds, observed in animal models to result in adverse pregnancy outcomes such as birth… (more)

▼ Nitrosatable drugs react with nitrite in the stomach to form N-nitroso compounds, observed in animal models to result in adverse pregnancy outcomes such as birth defects and reduced fetal weight. Previous studies examining prenatal exposure to medications classified as nitrosatable have observed an increased risk of preterm delivery. Vitamin C is a known nitrosation inhibitor. Using data from mothers (controls) of babies without major birth defects from the National Birth Defects Prevention Study, we examined the relation between preterm births and: 1) prenatal nitrosatable drug usage; 2) dietary intake of nitrates/nitrites; 3) joint exposures to nitrosatable drugs and nitrate/nitrite intake; and 4) nitrosatable drugs and vitamin C intake among 496 case-mothers of preterm infants and 5398 control-mothers who delivered full term babies from 1997-2005. An increased risk of preterm births was observed with secondary amine exposure during the second (adjusted hazard ratio (aHR) 1.37, [95% confidence interval (CI) 1.05, 1.79]) and third (aHR 1.34, [95% CI 1.02, 1.76]) trimester. A protective effect was detected with high levels of plant nitrites (aHR 0.72, [95% CI 0.53, 0.97]). Exposure to secondary amines and high levels of nitrite were associated with preterm births, having an increased risk with first (aHR 1.84, [95% CI 1.14, 2.98]), second (aHR 1.89, [95% CI 1.17, 3.07]), and third (aHR 2.00, [95% CI 1.22, 3.29]) trimester exposure. Lower risk of moderately preterm births was observed with second trimester amide exposure in conjunction with higher levels of dietary vitamin C (aHR 1.14, [95% CI 0.66, 1.98]) compared to <85 mg/day (aHR 2.08, [95% CI 1.25, 3.47]). Prenatal exposure to nitrosatable drugs during the second and third trimester, particularly secondary amines, might increase risk of preterm delivery. In addition, nitrosatable drugs, especially secondary and tertiary amines, and higher levels of dietary nitrite (including animal, plant, and total) may increase risk of preterm births. However, dietary vitamin C intake ???85 mg/day may attenuate the association between nitrosatable drug use during the second trimester and preterm and moderately preterm births. In this study population, daily vitamin C supplementation did not appear to confer the same benefits. Advisors/Committee Members: Brender, Jean D (advisor).

Subjects/Keywords: preterm births

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APA (6^th Edition):

Vuong, A. M. (2013). Prenatal Exposure to Nitrates, Nitrites, and Nitrosatable Drugs and Preterm Births. (Thesis). Texas Digital Library. Retrieved from http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66688

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vuong, Ann Minh. “Prenatal Exposure to Nitrates, Nitrites, and Nitrosatable Drugs and Preterm Births.” 2013. Thesis, Texas Digital Library. Accessed April 22, 2021. http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66688.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vuong, Ann Minh. “Prenatal Exposure to Nitrates, Nitrites, and Nitrosatable Drugs and Preterm Births.” 2013. Web. 22 Apr 2021.

Vancouver:

Vuong AM. Prenatal Exposure to Nitrates, Nitrites, and Nitrosatable Drugs and Preterm Births. [Internet] [Thesis]. Texas Digital Library; 2013. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66688.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vuong AM. Prenatal Exposure to Nitrates, Nitrites, and Nitrosatable Drugs and Preterm Births. [Thesis]. Texas Digital Library; 2013. Available from: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66688

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manitoba

2. Williamson, Kathryn E. Social cognition and social outcomes in children born at very low birth weight.

Degree: Psychology, 2014, University of Manitoba

URL: http://hdl.handle.net/1993/23585

► Social cognition is a broad construct that refers to the fundamental abilities to perceive, store, analyze, process, categorize, reason with, and behave towards other conspecifics… (more)

Subjects/Keywords: preterm birth

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APA (6^th Edition):

Williamson, K. E. (2014). Social cognition and social outcomes in children born at very low birth weight. (Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/23585

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Williamson, Kathryn E. “Social cognition and social outcomes in children born at very low birth weight.” 2014. Thesis, University of Manitoba. Accessed April 22, 2021. http://hdl.handle.net/1993/23585.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Williamson, Kathryn E. “Social cognition and social outcomes in children born at very low birth weight.” 2014. Web. 22 Apr 2021.

Vancouver:

Williamson KE. Social cognition and social outcomes in children born at very low birth weight. [Internet] [Thesis]. University of Manitoba; 2014. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/1993/23585.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Williamson KE. Social cognition and social outcomes in children born at very low birth weight. [Thesis]. University of Manitoba; 2014. Available from: http://hdl.handle.net/1993/23585

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Namibia

3. Velikoshi-Indongo, Eva-Angelina N. Investigations into experiences of mothers who delivered and are caring for preterm babies in nothern Namibian state hospitals .

Degree: 2013, University of Namibia

URL: http://hdl.handle.net/11070/922

► Prematurity has become a major global cause of death in neonates. The number of preterm babies has increased significantly in the past ten to fifteen… (more)

▼ Prematurity has become a major global cause of death in neonates. The number of preterm babies has increased significantly in the past ten to fifteen years, creating a public health crisis in the financial and social fraternities. While prematurity has become a public health crisis, delivering and caring for a preterm baby also affects the emotional and social well-being of the mothers who delivered preterm babies. Most preterm infants are born ill, or have difficulties in adapting to extra-uterine life because of immature body systems and organs. As a result, preterm birth and caring for a preterm baby becomes a stressful and worrisome situation for parents. However, some preterm babies do survive, and they can quite soon be discharged home with their mothers. But, although mothers may experience excitement and happiness at discharge, many are anxious and insecure about how to take care of their tiny babies at home. This creates another burden for the mothers, because they will be carrying on with the baby care at home without assistance. Therefore, nurses should be prepared to assist the mothers in this transitional period, by providing instructions and interventions that will give the mothers the necessary knowledge and skills to confidently and effectively care for their babies at home. This research was conducted in the Neonatal Intensive Care Unit (NICUs) of the Pediatric and Maternity Wards of Intermediate Hospital Oshakati. The study was undertaken as a qualitative, exploratory, descriptive and contextual study, aimed at understanding lived experiences of mothers regarding giving birth to a preterm baby and caring for him or her. In-depth interviews were conducted on eight mothers, who had been caring for their preterm babies for at least two weeks in the mentioned units. The researcher observed ethical implication pertaining to research conducting. Permission to conduct the study was sought from the concerned institutions. Ethical principles of informed consent, anonymity, confidentiality were adhered to. The study revealed that mothers who delivered preterm babies experienced emotional challenges, manifested in shock, fear, despair and sadness. It also showed that the mothers relied mainly on their religion in an attempt to cope with preterm birth. In addition, mothers experienced difficulties in bonding with their babies as well as apprehension in the care of their babies because they had inadequate information about preterm birth and preterm baby care. This caused them to have no foundations to build the discharge care planning at home after discharge from the hospital. Hence, a discharge health educational-support programme was developed, to address their emotional challenges in the care of their preterm babies as well as to address their educational needs. The programme aimed to empower the mothers with knowledge and skills to enable them to effectively and confidently continue caring for their babies at home, as well as to address the emotional challenges brought about by prematurity. The programme…

Subjects/Keywords: Preterm babies

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APA (6^th Edition):

Velikoshi-Indongo, E. N. (2013). Investigations into experiences of mothers who delivered and are caring for preterm babies in nothern Namibian state hospitals . (Thesis). University of Namibia. Retrieved from http://hdl.handle.net/11070/922

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Velikoshi-Indongo, Eva-Angelina N. “Investigations into experiences of mothers who delivered and are caring for preterm babies in nothern Namibian state hospitals .” 2013. Thesis, University of Namibia. Accessed April 22, 2021. http://hdl.handle.net/11070/922.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Velikoshi-Indongo, Eva-Angelina N. “Investigations into experiences of mothers who delivered and are caring for preterm babies in nothern Namibian state hospitals .” 2013. Web. 22 Apr 2021.

Vancouver:

Velikoshi-Indongo EN. Investigations into experiences of mothers who delivered and are caring for preterm babies in nothern Namibian state hospitals . [Internet] [Thesis]. University of Namibia; 2013. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/11070/922.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Velikoshi-Indongo EN. Investigations into experiences of mothers who delivered and are caring for preterm babies in nothern Namibian state hospitals . [Thesis]. University of Namibia; 2013. Available from: http://hdl.handle.net/11070/922

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Noguchi, Taketoshi; Sado, Toshiyuki; Naruse, Katsuhiko. Vaginal fluid pH and buffer capacity for predicting false preterm labor in Japanese women. : 日本人女性における切迫早産予測のための腟分泌物pHと腟分泌物緩衝能に関する研究.

Degree: 博士（医学）, 2016, Nara Medical University / 奈良県立医科大学

URL: http://hdl.handle.net/10564/3273

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OBJECTIVE: To determine the relationship between preterm labor and delivery, and the pH and buffer capacity of vaginal secretions. METHODS: Between January 1, 2009 and… (more)

Subjects/Keywords: Buffering capacity; Prediction; Preterm delivery; Preterm labor; Threatened preterm labor; Vaginal pH

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APA (6^th Edition):

Noguchi, Taketoshi; Sado, Toshiyuki; Naruse, K. (2016). Vaginal fluid pH and buffer capacity for predicting false preterm labor in Japanese women. : 日本人女性における切迫早産予測のための腟分泌物pHと腟分泌物緩衝能に関する研究. (Thesis). Nara Medical University / 奈良県立医科大学. Retrieved from http://hdl.handle.net/10564/3273

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Noguchi, Taketoshi; Sado, Toshiyuki; Naruse, Katsuhiko. “Vaginal fluid pH and buffer capacity for predicting false preterm labor in Japanese women. : 日本人女性における切迫早産予測のための腟分泌物pHと腟分泌物緩衝能に関する研究.” 2016. Thesis, Nara Medical University / 奈良県立医科大学. Accessed April 22, 2021. http://hdl.handle.net/10564/3273.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Noguchi, Taketoshi; Sado, Toshiyuki; Naruse, Katsuhiko. “Vaginal fluid pH and buffer capacity for predicting false preterm labor in Japanese women. : 日本人女性における切迫早産予測のための腟分泌物pHと腟分泌物緩衝能に関する研究.” 2016. Web. 22 Apr 2021.

Vancouver:

Noguchi, Taketoshi; Sado, Toshiyuki; Naruse K. Vaginal fluid pH and buffer capacity for predicting false preterm labor in Japanese women. : 日本人女性における切迫早産予測のための腟分泌物pHと腟分泌物緩衝能に関する研究. [Internet] [Thesis]. Nara Medical University / 奈良県立医科大学; 2016. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/10564/3273.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Noguchi, Taketoshi; Sado, Toshiyuki; Naruse K. Vaginal fluid pH and buffer capacity for predicting false preterm labor in Japanese women. : 日本人女性における切迫早産予測のための腟分泌物pHと腟分泌物緩衝能に関する研究. [Thesis]. Nara Medical University / 奈良県立医科大学; 2016. Available from: http://hdl.handle.net/10564/3273

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Dalhousie University

5. Jones, Donna. RATES AND DETERMINANTS OF PRETERM BIRTH IN PREGNANCIES COMPLICATED BY DIABETES MELLITUS.

Degree: MS, Department of Community Health & Epidemiology, 2014, Dalhousie University

URL: http://hdl.handle.net/10222/53788

► This population-based retrospective cohort study involving all singleton births between 1988 and 2009 in Nova Scotia estimated the rate of preterm birth less than 37… (more)

Subjects/Keywords: Pregnancy; Diabetes mellitus; Preterm birth

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APA (6^th Edition):

Jones, D. (2014). RATES AND DETERMINANTS OF PRETERM BIRTH IN PREGNANCIES COMPLICATED BY DIABETES MELLITUS. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/53788

Chicago Manual of Style (16^th Edition):

Jones, Donna. “RATES AND DETERMINANTS OF PRETERM BIRTH IN PREGNANCIES COMPLICATED BY DIABETES MELLITUS.” 2014. Masters Thesis, Dalhousie University. Accessed April 22, 2021. http://hdl.handle.net/10222/53788.

MLA Handbook (7^th Edition):

Jones, Donna. “RATES AND DETERMINANTS OF PRETERM BIRTH IN PREGNANCIES COMPLICATED BY DIABETES MELLITUS.” 2014. Web. 22 Apr 2021.

Vancouver:

Jones D. RATES AND DETERMINANTS OF PRETERM BIRTH IN PREGNANCIES COMPLICATED BY DIABETES MELLITUS. [Internet] [Masters thesis]. Dalhousie University; 2014. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/10222/53788.

Council of Science Editors:

Jones D. RATES AND DETERMINANTS OF PRETERM BIRTH IN PREGNANCIES COMPLICATED BY DIABETES MELLITUS. [Masters Thesis]. Dalhousie University; 2014. Available from: http://hdl.handle.net/10222/53788

6. Enami, Nobuko; Itaya-Hironaka, Asako; Yamauchi, Akiyo; Sakuramoto-Tsuchida, Sumiyo; Takasawa, Shin. The CD38 genotype (rs1800561 (4693C>T): R140W) is associated with an increased risk of admission to the neonatal intensive care unit. : CD38 genotype (rs1800561 (4693C > T): R140W)は新生児集中治療室への入院のリスク増加に関連する.

Degree: 博士（医学）, 2015, Nara Medical University / 奈良県立医科大学

URL: http://hdl.handle.net/10564/3100

►

BACKGROUNDS:Preterm birth (PTB)/admission to the neonatal intensive care unit (NICU) is a complex disorder associated with significant neonatal mortality and morbidity and long-term adverse health… (more)

Subjects/Keywords: CD38; Preterm birth; OXTR; SNP

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APA (6^th Edition):

Enami, Nobuko; Itaya-Hironaka, Asako; Yamauchi, Akiyo; Sakuramoto-Tsuchida, Sumiyo; Takasawa, S. (2015). The CD38 genotype (rs1800561 (4693C>T): R140W) is associated with an increased risk of admission to the neonatal intensive care unit. : CD38 genotype (rs1800561 (4693C > T): R140W)は新生児集中治療室への入院のリスク増加に関連する. (Thesis). Nara Medical University / 奈良県立医科大学. Retrieved from http://hdl.handle.net/10564/3100

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Enami, Nobuko; Itaya-Hironaka, Asako; Yamauchi, Akiyo; Sakuramoto-Tsuchida, Sumiyo; Takasawa, Shin. “The CD38 genotype (rs1800561 (4693C>T): R140W) is associated with an increased risk of admission to the neonatal intensive care unit. : CD38 genotype (rs1800561 (4693C > T): R140W)は新生児集中治療室への入院のリスク増加に関連する.” 2015. Thesis, Nara Medical University / 奈良県立医科大学. Accessed April 22, 2021. http://hdl.handle.net/10564/3100.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Enami, Nobuko; Itaya-Hironaka, Asako; Yamauchi, Akiyo; Sakuramoto-Tsuchida, Sumiyo; Takasawa, Shin. “The CD38 genotype (rs1800561 (4693C>T): R140W) is associated with an increased risk of admission to the neonatal intensive care unit. : CD38 genotype (rs1800561 (4693C > T): R140W)は新生児集中治療室への入院のリスク増加に関連する.” 2015. Web. 22 Apr 2021.

Vancouver:

Enami, Nobuko; Itaya-Hironaka, Asako; Yamauchi, Akiyo; Sakuramoto-Tsuchida, Sumiyo; Takasawa S. The CD38 genotype (rs1800561 (4693C>T): R140W) is associated with an increased risk of admission to the neonatal intensive care unit. : CD38 genotype (rs1800561 (4693C > T): R140W)は新生児集中治療室への入院のリスク増加に関連する. [Internet] [Thesis]. Nara Medical University / 奈良県立医科大学; 2015. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/10564/3100.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Enami, Nobuko; Itaya-Hironaka, Asako; Yamauchi, Akiyo; Sakuramoto-Tsuchida, Sumiyo; Takasawa S. The CD38 genotype (rs1800561 (4693C>T): R140W) is associated with an increased risk of admission to the neonatal intensive care unit. : CD38 genotype (rs1800561 (4693C > T): R140W)は新生児集中治療室への入院のリスク増加に関連する. [Thesis]. Nara Medical University / 奈良県立医科大学; 2015. Available from: http://hdl.handle.net/10564/3100

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

7. Luk, Yunnie. Do VLBW Infants Continue to Acquire Growth Deficits during their In-hospital Stay?.

Degree: 2017, University of Toronto

URL: http://hdl.handle.net/1807/97235

►

The purpose of this study was to determine whether very low birth weight (VLBW) infants continue to leave the hospital growth restricted, and to explore… (more)

Subjects/Keywords: Growth; Infants; Preterm; 0570

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APA (6^th Edition):

Luk, Y. (2017). Do VLBW Infants Continue to Acquire Growth Deficits during their In-hospital Stay?. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/97235

Chicago Manual of Style (16^th Edition):

Luk, Yunnie. “Do VLBW Infants Continue to Acquire Growth Deficits during their In-hospital Stay?.” 2017. Masters Thesis, University of Toronto. Accessed April 22, 2021. http://hdl.handle.net/1807/97235.

MLA Handbook (7^th Edition):

Luk, Yunnie. “Do VLBW Infants Continue to Acquire Growth Deficits during their In-hospital Stay?.” 2017. Web. 22 Apr 2021.

Vancouver:

Luk Y. Do VLBW Infants Continue to Acquire Growth Deficits during their In-hospital Stay?. [Internet] [Masters thesis]. University of Toronto; 2017. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/1807/97235.

Council of Science Editors:

Luk Y. Do VLBW Infants Continue to Acquire Growth Deficits during their In-hospital Stay?. [Masters Thesis]. University of Toronto; 2017. Available from: http://hdl.handle.net/1807/97235

University of Newcastle

8. Philpott-Robinson, Kelsey Rose. Characteristics and moderators of sensory modulation in infants, in the first year of life.

Degree: MPhil, 2017, University of Newcastle

URL: http://hdl.handle.net/1959.13/1384959

►

Masters Research - Masters of Philosophy (MPhil)

Preterm infants are at higher risk of poor neurodevelopmental and sensory modulation outcomes. There is growing interest in… (more)

▼

Masters Research - Masters of Philosophy (MPhil)

Preterm infants are at higher risk of poor neurodevelopmental and sensory modulation outcomes. There is growing interest in determining if preterm infants display more sensory modulation difficulties in the first year of life when compared to their full term peers, although no research to date has employed an assessment protocol using parent-report, clinical observation and cardiac autonomic function. Identification of sensory modulation difficulties in early infancy may inform early intervention procedures for the preterm infant population to improve everyday participation. Utilising a multimodal sensory modulation measurement protocol, the aims of this thesis were to: 1) elucidate the sensory modulation of infants at 12 months of age, using a multimodal sensory assessment approach including parent-report, clinical observation of sensory modulation, and autonomic cardiac function and 2) identify the relationship of early sensory environment, developmental age and gestational age with sensory modulation issues in infants at 12 months. A cross-sectional study and scoping review were implemented to address these aims. Sixty-eight infants (mean age 12.8 months) participated in the cross-sectional study and were recruited from the John Hunter Children’s Hospital, and pre-existing Breathing for Life Trial- Infant Development study. The majority of participants were born full term (n=50) and recruited from the Breathing for Life Trial-Infant Development study (n=42). Parent report data was collected using the Toddler Sensory Profile 2, and clinical observation collected via the Test of Sensory Function in Infants, which was undertaken whilst the infant wore a portable electrocardiogram to collect cardiac autonomic function. General developmental data was collected via administration of the Bayley Scales of Infant and Toddler Development-Third Edition. All testing was completed at the Hunter Medical Research Institute. Overall, our study did not find evidence of sensory modulation difficulties in preterm infants at 12 months of age, and there was a general pattern of typical sensory modulation both from parent-report and performance-based assessment. Trends in the physiological data suggest a possible biomarker for maladaptive responses to sensory stimuli in preterm infants, given that that the autonomic nervous system of preterm infants appeared to be immature compared to their full term peers. A weak relationship between developmental age and sensory modulation was identified, and preterm infants were found to have immature autonomic nervous system functioning resulting in dysregulation of their adaptive response to challenging stimuli. No relationships between preterm birth and sensory modulation difficulties at 12 months of age were found. The scoping review revealed a lack of high quality evidence pertaining to long term sensory and developmental outcomes of infants born preterm and admitted to the NICU, although the search strategy may limit the generalisability of…

Advisors/Committee Members: University of Newcastle. Faculty of Health & Medicine, School of Health Sciences.

Subjects/Keywords: preterm; development; sensory modulation; infants

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APA (6^th Edition):

Philpott-Robinson, K. R. (2017). Characteristics and moderators of sensory modulation in infants, in the first year of life. (Masters Thesis). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1384959

Chicago Manual of Style (16^th Edition):

Philpott-Robinson, Kelsey Rose. “Characteristics and moderators of sensory modulation in infants, in the first year of life.” 2017. Masters Thesis, University of Newcastle. Accessed April 22, 2021. http://hdl.handle.net/1959.13/1384959.

MLA Handbook (7^th Edition):

Philpott-Robinson, Kelsey Rose. “Characteristics and moderators of sensory modulation in infants, in the first year of life.” 2017. Web. 22 Apr 2021.

Vancouver:

Philpott-Robinson KR. Characteristics and moderators of sensory modulation in infants, in the first year of life. [Internet] [Masters thesis]. University of Newcastle; 2017. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/1959.13/1384959.

Council of Science Editors:

Philpott-Robinson KR. Characteristics and moderators of sensory modulation in infants, in the first year of life. [Masters Thesis]. University of Newcastle; 2017. Available from: http://hdl.handle.net/1959.13/1384959

University of Miami

9. Veerapen, Muthu Kumar. The Genetics of Preterm Birth.

Degree: PhD, Biochemistry and Molecular Biology (Medicine), 2016, University of Miami

URL: https://scholarlyrepository.miami.edu/oa_dissertations/1673

► Defined as live births prior to the completion of 37 weeks of gestation, preterm birth (PTB) affects up to 13% of all US deliveries.… (more)

▼ Defined as live births prior to the completion of 37 weeks of gestation, preterm birth (PTB) affects up to 13% of all US deliveries. PTB is one of the largest causes of perinatal morbidity and mortality resulting for a large economic burden. With an overall heritability of up to 37%, PTB is a multifactorial condition and is poorly understood. Despite being highly ancestry variable in affectation, few replicable studies have identified variants, transcriptional or epigenetic changes. The objective of this study is to utilize a multi-omics approach in well-characterized SPTB cohorts: exome sequencing in Latin-American infant SPTB cases; and RNA sequencing and methylation genotyping in a white-Caucasian case/control longitudinal cohort. For the Latin-American cohort, I performed a personal genome approach in analyzing the individuals and performing a gene-based analysis method for identifying and prioritizing potentially damaging genes. Many developmental pathways were highly enriched e.g. NRAS signaling pathway by the resulting genes where IP3R was frequent in most pathways. This could elude towards the infants being affected by intrauterine growth restriction (IUGR) and thereby causing SPTB. For the longitudinal cohort taken at 3 time points: gestation, pregnancy, and post-partum, I performed RNA sequencing and genotyping analysis separately in a linear model framework and integrated using Spearman’s rank correlation. Based on 3,408 differentially expressed transcripts and 20,448 differentially methylated positions (both, q < 0.05), I identified eleven candidate regulatory changes. CHIT1 (ρ = -0.69) had the highest inverse correlation between the data types and held most promise in clinical utility. CHIT1 is clinically used to test for decreased levels of -glucocerebrosidase in patients with Gaucher’s disease and a role in increased immune responses. Therefore, CHIT1 has ease in clinical use for the potential diagnosis of mothers during pregnancy for PTB. Upon integrating between the results of cohort via network analysis, I observed trends in a dysregulation in immunological genes supported by the observation of hub genes such MMP-8, IL-6 and NIK (MAP3K12). To the best of my knowledge, the multi-omics approach towards understanding the etiology of PTB is the first reported in current literature. The genes identified in this study could therefore be used towards potential development of therapeutic targets in PTB. Advisors/Committee Members: Olaf A. Bodamer, Ralf Landgraf, Stephan Zuchner, Juan Young, JoNell E. Potter.

Subjects/Keywords: Preterm; Genetics; Epidemiology; Perinatology; Genomics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Veerapen, M. K. (2016). The Genetics of Preterm Birth. (Doctoral Dissertation). University of Miami. Retrieved from https://scholarlyrepository.miami.edu/oa_dissertations/1673

Chicago Manual of Style (16^th Edition):

Veerapen, Muthu Kumar. “The Genetics of Preterm Birth.” 2016. Doctoral Dissertation, University of Miami. Accessed April 22, 2021. https://scholarlyrepository.miami.edu/oa_dissertations/1673.

MLA Handbook (7^th Edition):

Veerapen, Muthu Kumar. “The Genetics of Preterm Birth.” 2016. Web. 22 Apr 2021.

Vancouver:

Veerapen MK. The Genetics of Preterm Birth. [Internet] [Doctoral dissertation]. University of Miami; 2016. [cited 2021 Apr 22]. Available from: https://scholarlyrepository.miami.edu/oa_dissertations/1673.

Council of Science Editors:

Veerapen MK. The Genetics of Preterm Birth. [Doctoral Dissertation]. University of Miami; 2016. Available from: https://scholarlyrepository.miami.edu/oa_dissertations/1673

University of Debrecen

10. Umeh, Chioma Chika. Management of Preterm Labor .

Degree: DE – Általános Orvostudományi Kar, University of Debrecen

URL: http://hdl.handle.net/2437/229977

► Preterm birth occurs in approximately 12% of pregnancies in developed countries and as high as 25% in developing countries. Preterm birth accounts for up to… (more)

Subjects/Keywords: Preterm Labor

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APA (6^th Edition):

Umeh, C. C. (n.d.). Management of Preterm Labor . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/229977

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Umeh, Chioma Chika. “Management of Preterm Labor .” Thesis, University of Debrecen. Accessed April 22, 2021. http://hdl.handle.net/2437/229977.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Umeh, Chioma Chika. “Management of Preterm Labor .” Web. 22 Apr 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Umeh CC. Management of Preterm Labor . [Internet] [Thesis]. University of Debrecen; [cited 2021 Apr 22]. Available from: http://hdl.handle.net/2437/229977.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Umeh CC. Management of Preterm Labor . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/229977

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

University of Debrecen

11. Krief, Yifat. Pharmacotherapy of preterm labor .

Degree: DE – Általános Orvostudományi Kar, University of Debrecen

URL: http://hdl.handle.net/2437/242874

► This thesis includes the main characteristics of preterm labor: risk factors, epidemiology, pathophysiology, etiology, clinical presentation, risk assessment, diagnosis and treatment. I conclude the main… (more)

Subjects/Keywords: preterm labor

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APA (6^th Edition):

Krief, Y. (n.d.). Pharmacotherapy of preterm labor . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/242874

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Krief, Yifat. “Pharmacotherapy of preterm labor .” Thesis, University of Debrecen. Accessed April 22, 2021. http://hdl.handle.net/2437/242874.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Krief, Yifat. “Pharmacotherapy of preterm labor .” Web. 22 Apr 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Krief Y. Pharmacotherapy of preterm labor . [Internet] [Thesis]. University of Debrecen; [cited 2021 Apr 22]. Available from: http://hdl.handle.net/2437/242874.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Krief Y. Pharmacotherapy of preterm labor . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/242874

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Brigham Young University

12. Huggins, Leslie Jane. Immunization Status of NICU Graduates at a Tertiary Care Children's Hospital.

Degree: MS, 2016, Brigham Young University

URL: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7333&context=etd

► The objectives of this study were to determine the current rates of immunization and identify variables associated with immunizations of NICU graduates who were 60… (more)

Subjects/Keywords: NICU; preterm; immunizations; Nursing

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APA (6^th Edition):

Huggins, L. J. (2016). Immunization Status of NICU Graduates at a Tertiary Care Children's Hospital. (Masters Thesis). Brigham Young University. Retrieved from https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7333&context=etd

Chicago Manual of Style (16^th Edition):

Huggins, Leslie Jane. “Immunization Status of NICU Graduates at a Tertiary Care Children's Hospital.” 2016. Masters Thesis, Brigham Young University. Accessed April 22, 2021. https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7333&context=etd.

MLA Handbook (7^th Edition):

Huggins, Leslie Jane. “Immunization Status of NICU Graduates at a Tertiary Care Children's Hospital.” 2016. Web. 22 Apr 2021.

Vancouver:

Huggins LJ. Immunization Status of NICU Graduates at a Tertiary Care Children's Hospital. [Internet] [Masters thesis]. Brigham Young University; 2016. [cited 2021 Apr 22]. Available from: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7333&context=etd.

Council of Science Editors:

Huggins LJ. Immunization Status of NICU Graduates at a Tertiary Care Children's Hospital. [Masters Thesis]. Brigham Young University; 2016. Available from: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7333&context=etd

University of Illinois – Chicago

13. Griffith, Thao T. The Relationship between Duration of Tube Feeding and Oral Feeding Success in Preterm Infants.

Degree: 2017, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/21962

► Background. Preterm infants often require extended tube feeding and are challenged to achieve oral feeding success (OFS, ability to consume 100% of the prescribed volume… (more)

Subjects/Keywords: preterm infants; oral feeding

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APA (6^th Edition):

Griffith, T. T. (2017). The Relationship between Duration of Tube Feeding and Oral Feeding Success in Preterm Infants. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/21962

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Griffith, Thao T. “The Relationship between Duration of Tube Feeding and Oral Feeding Success in Preterm Infants.” 2017. Thesis, University of Illinois – Chicago. Accessed April 22, 2021. http://hdl.handle.net/10027/21962.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Griffith, Thao T. “The Relationship between Duration of Tube Feeding and Oral Feeding Success in Preterm Infants.” 2017. Web. 22 Apr 2021.

Vancouver:

Griffith TT. The Relationship between Duration of Tube Feeding and Oral Feeding Success in Preterm Infants. [Internet] [Thesis]. University of Illinois – Chicago; 2017. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/10027/21962.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Griffith TT. The Relationship between Duration of Tube Feeding and Oral Feeding Success in Preterm Infants. [Thesis]. University of Illinois – Chicago; 2017. Available from: http://hdl.handle.net/10027/21962

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Edinburgh

14. Makieva, Sofia. Investigating the role of androgens in myometrial biology during pregnancy.

Degree: PhD, 2015, University of Edinburgh

URL: http://hdl.handle.net/1842/15950

► Understanding the physiology of pregnancy enables effective management of pregnancy complications that could otherwise be life threatening for both mother and fetus. A functional uterus… (more)

▼ Understanding the physiology of pregnancy enables effective management of pregnancy complications that could otherwise be life threatening for both mother and fetus. A functional uterus (a) retains the fetus in utero during pregnancy without initiating stretch-induced contractions and (b) is able to dilate the cervix and contract the myometrium at term to deliver the fetus. The onset of labour is associated with successful cervical remodelling and contraction of myometrium, arising from concomitant activation of uterine immune and endocrine systems. A large body of evidence suggest that the action of local sex hormones may drive changes occurring in the uterine microenvironment at term. Although there have been a number of studies considering the potential role(s) played by progesterone and estrogens at the time of parturition, the role of androgens has received less scrutiny. The overarching aim of this thesis was to investigate the potential roles of androgens in myometrial biology at the time of pregnancy. We examined both the genetranscription dependent (genomic) and independent (non-genomic) action of androgens on the uterine smooth muscle, employing in vitro, ex vivo, and in vivo approaches. We found that the androgen receptor (AR) mRNA was significantly increased in the myometrium during labour when compared to the term non-labouring myometrium. Our gene expression studies revealed that ligand-dependent AR signalling in the myometrium might play a role in regulation of uterine smooth muscle cell contractility. We explored the effect of androgens on contraction of uterine smooth muscle strips obtained from both human myometrial biopsies collected at term and murine uterine horns. We found that testosterone (T) and dihydrotestosterone (DHT) in a range of 10-100 μM concentrations rapidly relaxed spontaneous and oxytocin-initiated contractions. The relaxant effect was not mediated by the classical intracellular AR nor was cell-surface initiated as shown by experiments employing a specific AR antagonist (flutamide) and a cell-surface impermeable androgen (TBSA). We investigated whether the relaxant effect was specific to androgens or a generic effect of sex hormones. We demonstrated that both estradiol (E2) and progesterone (P4) were also capable of relaxing the human and murine myometrium at the same dose range. In addition, a sex hormone “cocktail” (all four sex hormones combined at 10 μM dose each) mimicked the relaxant effect that each individual sex hormone elicited at a 40 μM dose, implying that the effect was possibly attributable to the steroid structure of the sex hormones. To study the underlying molecular events that mediate the relaxant effect of sex hormones observed ex vivo, we employed two human myometrial cell lines namely PHM1-41s and UtSMCs. We demonstrated that the androgen-induced relaxation in vitro was not induced by cell death but was mediated by a physiological mechanism whereby incubation with the androgen impaired the stimulated-Ca2+ entry into the uterine myocytes, which in turn resulted…

Subjects/Keywords: 618.3; myometrium; preterm; contraction; androgens

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Makieva, S. (2015). Investigating the role of androgens in myometrial biology during pregnancy. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/15950

Chicago Manual of Style (16^th Edition):

Makieva, Sofia. “Investigating the role of androgens in myometrial biology during pregnancy.” 2015. Doctoral Dissertation, University of Edinburgh. Accessed April 22, 2021. http://hdl.handle.net/1842/15950.

MLA Handbook (7^th Edition):

Makieva, Sofia. “Investigating the role of androgens in myometrial biology during pregnancy.” 2015. Web. 22 Apr 2021.

Vancouver:

Makieva S. Investigating the role of androgens in myometrial biology during pregnancy. [Internet] [Doctoral dissertation]. University of Edinburgh; 2015. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/1842/15950.

Council of Science Editors:

Makieva S. Investigating the role of androgens in myometrial biology during pregnancy. [Doctoral Dissertation]. University of Edinburgh; 2015. Available from: http://hdl.handle.net/1842/15950

University of Melbourne

15. Burnett, Alice Claudia. Mood and anxiety outcomes in adolescents born with extremely low birthweight or extremely preterm: prevalence and neuroanatomy.

Degree: 2012, University of Melbourne

URL: http://hdl.handle.net/11343/37688

► Preterm birth is associated with poor outcome in a range of domains, which can persist into adolescence and beyond. This may include poor mental health… (more)

▼ Preterm birth is associated with poor outcome in a range of domains, which can persist into adolescence and beyond. This may include poor mental health outcomes, and particularly, anxiety and depressive symptoms. To date, studies of mood and anxiety outcomes in preterm groups have mainly used dimensional measures of symptoms; only a handful employ clinical diagnostic instruments and these largely focus on recent symptoms. Our understanding of the prevalence of clinically diagnosable disorders is consequently limited, particularly in late adolescence and for those born since 1990. Prematurity at birth can also have a significant and longstanding impact on brain development. An extended medial network, including the hippocampus, amygdala, and medial prefrontal cortex, is implicated in emotion regulation, as well as clinical mood and anxiety disorders. Hippocampus, amygdala, and prefrontal structure may be altered in preterm samples, but potential relationships between these brain regions and emotional outcomes are yet to be explored in preterm survivors. This study aimed to address these limitations in the current literature by i) characterising mood and anxiety outcomes in adolescents born extremely low birthweight or extremely preterm (ELBW/EP), ii) characterising the structure of regions in the extended medial network, and iii) investigating the relationships between these outcomes and brain structure. A number of specific hypotheses arose from this research question. Firstly, it was expected that the ELBW/EP group would report more recent symptoms, more frequently meet diagnostic criteria for current or past disorder, and more strongly endorse personality traits associated with anxiety and depression than a normal birthweight (>2500g; NBW), full-term (>36 weeks; FT) control group. Secondly, it was expected that ELBW/EP participants may have smaller hippocampus, amygdala, and ventromedial prefrontal cortex volumes, and thinner ventromedial prefrontal cortices, than NBW participants. Finally, it was predicted that structural reductions in these regions of interest would be associated with greater mood and anxiety symptoms, and a history of clinically diagnosable disorder, in ELBW/EP and NBW participants. This study assessed 215 ELBW/EP and 157 NBW adolescents who were born in 1991 and 1992 in the state of Victoria, Australia. Participants from a prospective geographical cohort were followed up at age 18 and completed measures of mood and anxiety symptoms and disorders (including questionnaires and a structured clinical interview), as well as personality traits. Participants also underwent structural MRI scanning, and cortical and subcortical brain volumes were generated using FreeSurfer (v5.0). Unexpectedly, there was no elevation in clinically relevant recent or lifetime history of depression or anxiety in the ELBW/EP group. Although mood and anxiety disorders were more prevalent in…

Subjects/Keywords: preterm; depression; anxiety; MRI

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Burnett, A. C. (2012). Mood and anxiety outcomes in adolescents born with extremely low birthweight or extremely preterm: prevalence and neuroanatomy. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/37688

Chicago Manual of Style (16^th Edition):

Burnett, Alice Claudia. “Mood and anxiety outcomes in adolescents born with extremely low birthweight or extremely preterm: prevalence and neuroanatomy.” 2012. Doctoral Dissertation, University of Melbourne. Accessed April 22, 2021. http://hdl.handle.net/11343/37688.

MLA Handbook (7^th Edition):

Burnett, Alice Claudia. “Mood and anxiety outcomes in adolescents born with extremely low birthweight or extremely preterm: prevalence and neuroanatomy.” 2012. Web. 22 Apr 2021.

Vancouver:

Burnett AC. Mood and anxiety outcomes in adolescents born with extremely low birthweight or extremely preterm: prevalence and neuroanatomy. [Internet] [Doctoral dissertation]. University of Melbourne; 2012. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/11343/37688.

Council of Science Editors:

Burnett AC. Mood and anxiety outcomes in adolescents born with extremely low birthweight or extremely preterm: prevalence and neuroanatomy. [Doctoral Dissertation]. University of Melbourne; 2012. Available from: http://hdl.handle.net/11343/37688

University of Melbourne

16. Milne, Lisa Clare. Longitudinal outcome of a preterm birth: evaluation of an intervention program and an exploration of effects of maternal environment on preschool children born preterm.

Degree: 2013, University of Melbourne

URL: http://hdl.handle.net/11343/38635

► While survival rates of preterm infants continue to improve, a significant number of surviving preterm infants display ongoing cognitive and behavioural problems. Environmental factors, including… (more)

▼ While survival rates of preterm infants continue to improve, a significant number of surviving preterm infants display ongoing cognitive and behavioural problems. Environmental factors, including stress from medical and routine procedures in the Neonatal Intensive Care Unit (NICU) and problematic parent-infant interactions are now thought to influence developmental outcomes for preterm infants. The mother forms a large part of the infant’s environment and in the first 3 years of life environmental factors that may influence preterm infants include her relationship with the infant and also her capacity to organise, structure and regulate the infant’s interaction with other external experiences. In a landmark study (Nurcombe et al., 1984) found significant benefits emerging after 2 years on cognitive development (IQ )following early intervention in the NICU – the Mother Infant Transaction Program (MITP). The MITP is a relatively inexpensive parent-based program aimed at improving the neurodevelopmental outcomes for preterm infants. Study 1 was a follow-up at 36 months of 90 preterm infants, of less than 30 weeks gestation, who received either the intervention (a modified version of the MITP), or a control condition in a RCT. An ANOVA design was used with treatment entered as the fixed variable, and hospital and gender were entered as random variables. The results showed that there were no overall treatment effects on cognitive variables, executive function variables, or behavioural variables. However, the results were complex to interpret. In this field of study, where sample sizes are limited, consideration of the effect sizes is important, nonetheless the effect sizes in this study were unremarkable. While it may be that the results accurately reflect that at 36 months, the Premiestart modified MITP had no effect on the variables measured. Other possible explanations were that the preterm infants needed more time to recover and show the benefits of the intervention program, as shown in other studies where benefits emerged at later ages. Further it may have been that perhaps the measures were not sensitive enough to detect any differences between the groups, and finally it may be that improved standards of care in the NICU have reduced the impact of the intervention. It was also shown that the infants born at a later gestation, and who were less sick (as measured by length of hospital stay) had better cognitive achievement scores compared with the infants born earlier and who spent longer in hospital. Thus the MITP intervention may be effective only with very preterm infants, and not extremely preterm infants. Further follow-up research was recommended. Study 2 was one of the few reported studies exploring the relationship between maternal variables including: sensory profile, personality, maternal executive function and maternal emotion regulation on the neurobehavioural outcomes of preterm infants at 36 months,…

Subjects/Keywords: preterm; infant; outcome; maternal contribution

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APA (6^th Edition):

Milne, L. C. (2013). Longitudinal outcome of a preterm birth: evaluation of an intervention program and an exploration of effects of maternal environment on preschool children born preterm. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/38635

Chicago Manual of Style (16^th Edition):

Milne, Lisa Clare. “Longitudinal outcome of a preterm birth: evaluation of an intervention program and an exploration of effects of maternal environment on preschool children born preterm.” 2013. Doctoral Dissertation, University of Melbourne. Accessed April 22, 2021. http://hdl.handle.net/11343/38635.

MLA Handbook (7^th Edition):

Milne, Lisa Clare. “Longitudinal outcome of a preterm birth: evaluation of an intervention program and an exploration of effects of maternal environment on preschool children born preterm.” 2013. Web. 22 Apr 2021.

Vancouver:

Milne LC. Longitudinal outcome of a preterm birth: evaluation of an intervention program and an exploration of effects of maternal environment on preschool children born preterm. [Internet] [Doctoral dissertation]. University of Melbourne; 2013. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/11343/38635.

Council of Science Editors:

Milne LC. Longitudinal outcome of a preterm birth: evaluation of an intervention program and an exploration of effects of maternal environment on preschool children born preterm. [Doctoral Dissertation]. University of Melbourne; 2013. Available from: http://hdl.handle.net/11343/38635

Addis Ababa University

17. Liya, Befekadu. Presented in partial fulfillment of the requirements for the Degree of Master of Science in Biomedical Engineering .

Degree: 2017, Addis Ababa University

URL: http://etd.aau.edu.et/handle/123456789/21126

► Temperature instability in preterm neonates is one of the major causes of morbidity and mortality. The immature systems and organs of preterm neonates in combination… (more)

Subjects/Keywords: preterm neonates; NICU; body temperature

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APA (6^th Edition):

Liya, B. (2017). Presented in partial fulfillment of the requirements for the Degree of Master of Science in Biomedical Engineering . (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/handle/123456789/21126

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Liya, Befekadu. “Presented in partial fulfillment of the requirements for the Degree of Master of Science in Biomedical Engineering .” 2017. Thesis, Addis Ababa University. Accessed April 22, 2021. http://etd.aau.edu.et/handle/123456789/21126.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Liya, Befekadu. “Presented in partial fulfillment of the requirements for the Degree of Master of Science in Biomedical Engineering .” 2017. Web. 22 Apr 2021.

Vancouver:

Liya B. Presented in partial fulfillment of the requirements for the Degree of Master of Science in Biomedical Engineering . [Internet] [Thesis]. Addis Ababa University; 2017. [cited 2021 Apr 22]. Available from: http://etd.aau.edu.et/handle/123456789/21126.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Liya B. Presented in partial fulfillment of the requirements for the Degree of Master of Science in Biomedical Engineering . [Thesis]. Addis Ababa University; 2017. Available from: http://etd.aau.edu.et/handle/123456789/21126

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

18. Crawford, Tara Marie. The Effect of Washed vs Unwashed Packed Red Blood Cell Transfusion on Immune Responses in the Extremely Preterm Newborn: A Randomised Trial.

Degree: 2020, University of Adelaide

URL: http://hdl.handle.net/2440/129617

► Packed red blood cell (PRBC) transfusions continue to result in adverse inflammatory responses and increased rates of morbidity despite modifications in processing such as leukodepletion.… (more)

▼ Packed red blood cell (PRBC) transfusions continue to result in adverse inflammatory responses and increased rates of morbidity despite modifications in processing such as leukodepletion. It remains unknown if this is due to adverse physiological responses, inflammatory processes related to transfusion related immunomodulation (TRIM) or both. Washing of PRBCs may reduce the immunomodulatory potential and transfusion related adverse outcomes. This study aimed to investigate whether transfusion with washed leukodepleted PRBCs in the preterm newborn reduces post-transfusion inflammatory cytokine responses compared to transfusion with unwashed leukodepleted PRBCs, improving physiological stability. Extremely preterm newborns (n=154) were randomised to transfusion with unwashed or washed leukodepleted PRBCs, determined by the restrictive threshold of the PINT transfusion study, until primary hospital discharge (77 per arm). Plasma cytokines, markers of endothelial activation and measures of cardiorespiratory stability where measured pre- and post-transfusion. Transfusion with washed PRBCs resulted in decreases in pro-inflammatory cytokines while unwashed PRBCs resulted in increases in IL-17A and TNF. By the 3rd transfusion this response to unwashed PRBCs was associated with increases in MIF and PAI-1, markers of endothelial activation, an effect not seen with washed PRBCs. This response was influenced by donor sex with exposure to PRBCs from a female donor resulting in increases in pro-inflammatory cytokines, an effect ameliorated by PRBC washing. Changes over time and in response to the type of packed red blood cells transfused were seen with a greater reduction in cardiac output and increase in systemic vascular resistance and mean airway pressure seen in those infants transfused with washed PRBCs. However, none of these alterations met the current accepted definitions for either transfusion-associated circulatory overload or transfusion-associated lung injury. The current study suggests that the association between transfusion and poor outcome have a predominantly immunomodulatory basis, a relationship that may be altered by the use of washed packed red blood cells for the extremely preterm infant. The apparent lack of significant changes in cardio-respiratory responses to a transfusion may reflect the need for specific diagnostic criteria for transfusion related complication in the preterm newborn. The current results provide strong mechanistic data supporting a potentially beneficial effect of transfusion of washed packed red blood cells in this high-risk population. The next critical step is investigating whether the use of washed packed red blood cells is associated with a significant reduction in clinical outcomes, a finding which would have wide ranging implications for both transfusion medicine and the field of neonatology. Advisors/Committee Members: Robertson, Sarah (advisor), Andersen, Chad (advisor), Hodyl, Nicolette (advisor), School of Medicine (school).

Subjects/Keywords: Transfusion; Preterm Infant; Inflammation; Morbidity

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APA (6^th Edition):

Crawford, T. M. (2020). The Effect of Washed vs Unwashed Packed Red Blood Cell Transfusion on Immune Responses in the Extremely Preterm Newborn: A Randomised Trial. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/129617

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Crawford, Tara Marie. “The Effect of Washed vs Unwashed Packed Red Blood Cell Transfusion on Immune Responses in the Extremely Preterm Newborn: A Randomised Trial.” 2020. Thesis, University of Adelaide. Accessed April 22, 2021. http://hdl.handle.net/2440/129617.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Crawford, Tara Marie. “The Effect of Washed vs Unwashed Packed Red Blood Cell Transfusion on Immune Responses in the Extremely Preterm Newborn: A Randomised Trial.” 2020. Web. 22 Apr 2021.

Vancouver:

Crawford TM. The Effect of Washed vs Unwashed Packed Red Blood Cell Transfusion on Immune Responses in the Extremely Preterm Newborn: A Randomised Trial. [Internet] [Thesis]. University of Adelaide; 2020. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/2440/129617.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Crawford TM. The Effect of Washed vs Unwashed Packed Red Blood Cell Transfusion on Immune Responses in the Extremely Preterm Newborn: A Randomised Trial. [Thesis]. University of Adelaide; 2020. Available from: http://hdl.handle.net/2440/129617

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Melbourne

19. LIONG, STELLA. Identification of novel biomarkers in the cervicovaginal fluid to predict preterm birth.

Degree: 2013, University of Melbourne

URL: http://hdl.handle.net/11343/39755

► INTRODUCTION: Preterm birth is associated with major perinatal morbidity and mortality. Despite the many advances in modern obstetrics the rate of preterm birth is increasing.… (more)

▼ INTRODUCTION: Preterm birth is associated with major perinatal morbidity and mortality. Despite the many advances in modern obstetrics the rate of preterm birth is increasing. The discovery of novel biomarkers that could reliably identify women who will subsequently deliver preterm may allow for timely medical intervention and therapeutic treatments aimed at improving maternal and fetal outcomes. The cervicovaginal fluid (CVF) provides a rich source for the discovery of putative biomarkers of pathophysiological disorders of pregnancy. It is hypothesised that the biochemical alterations that occur in the cervix and the overlying fetal membranes with labour may be reflected in the CVF proteome. Given the multifactorial aetiology of preterm birth, women may present with different clinical presentations that lead to preterm birth. This thesis has investigated the CVF proteome of three clinical groups of women in order to discover putative novel biomarkers of preterm birth in: (i) asymptomatic women at risk of preterm labour (PTL); (ii) women with symptoms of threatened PTL; and (iii) asymptomatic women who subsequently experienced preterm premature rupture of the fetal membranes (preterm PROM). A functional proteomic approach was used to detect putative novel biomarkers of PTL or preterm PROM using two-dimensional gel electrophoresis (2DE) coupled with mass spectrometry. Validation of these differentially expressed proteins was performed using enzyme-linked immunosorbant assay (ELISA) or Western blot on an independent cohort. MAIN FINDINGS: Chapter 3 contains work that has been published in Reproduction. IL-1ra and thioredoxin were significantly decreased in asymptomatic women with subsequent PTL and predictive modelling found these biomarkers to be effective predictors of spontaneous preterm birth. Chapter 4 contains work that has been published in PLoS One. This study investigated the temporal changes in vitamin D binding protein (VDBP) in the CVF with approaching term and PTL. VDBP was increased in the CVF with approaching term and PTL. Predictive modelling analysis also found VDBP to be a reliable predictor of spontaneous term and PTL. The study presented in Chapter 5 identified a number differentially expressed protein in the CVF proteome of women presenting with threatened PTL. IL-1ra, IL-1α, IL-1β, VDBP, thioredoxin and albumin were significantly altered in the CVF of symptomatic women in threatened PTL with subsequent preterm birth. Modelling analysis using albumin & VDBP was superior to fetal fibronectin in predicting preterm birth. The study presented in Chapter 6 has been published in Reproduction and describes the proteomic analysis of CVF samples collected from asymptomatic women who subsequently experienced preterm PROM. Western blot analysis confirmed IL-1ra, annexin A3 and cystatin A to be significantly altered in the…

Subjects/Keywords: biomarkers; cervicovaginal fluid; proteomics; pregnancy; preterm birth; preterm labour

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APA (6^th Edition):

LIONG, S. (2013). Identification of novel biomarkers in the cervicovaginal fluid to predict preterm birth. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/39755

Chicago Manual of Style (16^th Edition):

LIONG, STELLA. “Identification of novel biomarkers in the cervicovaginal fluid to predict preterm birth.” 2013. Doctoral Dissertation, University of Melbourne. Accessed April 22, 2021. http://hdl.handle.net/11343/39755.

MLA Handbook (7^th Edition):

LIONG, STELLA. “Identification of novel biomarkers in the cervicovaginal fluid to predict preterm birth.” 2013. Web. 22 Apr 2021.

Vancouver:

LIONG S. Identification of novel biomarkers in the cervicovaginal fluid to predict preterm birth. [Internet] [Doctoral dissertation]. University of Melbourne; 2013. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/11343/39755.

Council of Science Editors:

LIONG S. Identification of novel biomarkers in the cervicovaginal fluid to predict preterm birth. [Doctoral Dissertation]. University of Melbourne; 2013. Available from: http://hdl.handle.net/11343/39755

University of Edinburgh

20. Rajagopal, Shalini Priscilla. Modulation of inflammation in the female reproductive tract.

Degree: PhD, 2014, University of Edinburgh

URL: http://hdl.handle.net/1842/17928

► Physiological inflammation occurs in the female reproductive tract, but pathological inflammation is implicated in reproductive pathologies such as preterm labour and endometrial cancer. Preterm labour… (more)

▼ Physiological inflammation occurs in the female reproductive tract, but pathological inflammation is implicated in reproductive pathologies such as preterm labour and endometrial cancer. Preterm labour (PTL, before 37 weeks of gestation) is the leading cause of preterm birth, neonatal mortality and perinatal morbidities. Endometrial cancer is the commonest gynaecological cancer, and its pathogenesis is characterised by chronic inflammation. The overall aims of this thesis were (i) to develop an in vitro model of myometrial-monocyte interactions to replicate the events occurring in the myometrium in preterm labour (ii) to determine the effects of potential therapeutics such as lipoxins, IL-10 and progesterone, on inflammation, and (iii) to characterise the lipoxin pathway in endometrial adenocarcinoma. Macrophages infiltrate the pregnant myometrium during labour; however the role of these cells is unclear. A myometrial-monocyte coculture model was developed either using non-pregnant primary myometrial smooth muscle cells (UtSMCs), or immortalised pregnant human myometrial cells (PHM1-41), with primary monocytes from term (38-41 weeks of gestation), non-labouring pregnant women. Cultures were stimulated with the toll-like receptor 4 agonist lipopolysaccharide (LPS), in the presence or absence of each of lipoxins, IL-10 and progesterone. A significant and synergistic increase in IL-6 and IL-8 secretion was found in the UtSMC/monocyte coculture after stimulation with LPS for 24 hours, compared to LPS-treated UtSMCs, or monocytes alone, but the increase in IL-6 and IL-8 secretion was not inhibited by lipoxin, epi-lipoxin or benzo-lipoxin. The PHM1-41/monocyte coculture both alone and in response to LPS treatment generated significantly increased IL-6 and IL-8 secretion, compared to vehicle treatment in the coculture and compared to the culture of either cell type alone. IL-1β and TNFα secretion were only detected from the PHM1/monocyte coculture, and monocytes alone. Use of a TNFα blocking antibody partially suppressed LPS-induced IL-6 and IL-8 secretion in the coculture. Coculture of PHM1/monocytes resulted in increased secretion of multiple mediators including pro-inflammatory cytokines, chemokines and growth factors compared to culture of either PHM1 cells or primary monocytes separately, both with vehicle and with LPS. IL-10 inhibited LPS-induced IL-6 and IL-8 secretion from the coculture, as did progesterone, which also inhibited GM-CSF, MCP-1 and CXCL5 secretion. Myocyte contraction, measured by PHM1-41 cells embedded in collagen was increased by primary monocyte treatment. This suggests that not only do infiltrating monocytes increase myometrial inflammation but they can induce myometrial smooth muscle contraction. In endometrial adenocarcinoma, the lipoxin synthesis enzymes, ALOX-5 and -15 and FPR2 mRNA expression were upregulated compared to proliferative phase endometrium, with FPR2, a reported lipoxin receptor, immunolocalised in endometrial adenocarcinoma tissue. Additionally, TNFα treatment of Ishikawa…

Subjects/Keywords: 618.3; inflammation; pregnancy; preterm; preterm labour; endometrial adenocarcinoma; monocyte

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APA (6^th Edition):

Rajagopal, S. P. (2014). Modulation of inflammation in the female reproductive tract. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/17928

Chicago Manual of Style (16^th Edition):

Rajagopal, Shalini Priscilla. “Modulation of inflammation in the female reproductive tract.” 2014. Doctoral Dissertation, University of Edinburgh. Accessed April 22, 2021. http://hdl.handle.net/1842/17928.

MLA Handbook (7^th Edition):

Rajagopal, Shalini Priscilla. “Modulation of inflammation in the female reproductive tract.” 2014. Web. 22 Apr 2021.

Vancouver:

Rajagopal SP. Modulation of inflammation in the female reproductive tract. [Internet] [Doctoral dissertation]. University of Edinburgh; 2014. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/1842/17928.

Council of Science Editors:

Rajagopal SP. Modulation of inflammation in the female reproductive tract. [Doctoral Dissertation]. University of Edinburgh; 2014. Available from: http://hdl.handle.net/1842/17928

21. Kamphuis, E.I. Preterm birth: Recurrence and risks of routine interventions.

Degree: 2019, NARCIS

URL: https://research.vumc.nl/en/publications/0927005a-d83c-4bfb-a888-90ebca65f948 ; urn:nbn:nl:ui:31-0927005a-d83c-4bfb-a888-90ebca65f948 ; 0927005a-d83c-4bfb-a888-90ebca65f948 ; urn:nbn:nl:ui:31-0927005a-d83c-4bfb-a888-90ebca65f948 ; https://research.vumc.nl/en/publications/0927005a-d83c-4bfb-a888-90ebca65f948

Subjects/Keywords: preterm birth; recurrent preterm birth

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APA (6^th Edition):

Kamphuis, E. I. (2019). Preterm birth: Recurrence and risks of routine interventions. (Doctoral Dissertation). NARCIS. Retrieved from https://research.vumc.nl/en/publications/0927005a-d83c-4bfb-a888-90ebca65f948 ; urn:nbn:nl:ui:31-0927005a-d83c-4bfb-a888-90ebca65f948 ; 0927005a-d83c-4bfb-a888-90ebca65f948 ; urn:nbn:nl:ui:31-0927005a-d83c-4bfb-a888-90ebca65f948 ; https://research.vumc.nl/en/publications/0927005a-d83c-4bfb-a888-90ebca65f948

Chicago Manual of Style (16^th Edition):

Kamphuis, E I. “Preterm birth: Recurrence and risks of routine interventions.” 2019. Doctoral Dissertation, NARCIS. Accessed April 22, 2021. https://research.vumc.nl/en/publications/0927005a-d83c-4bfb-a888-90ebca65f948 ; urn:nbn:nl:ui:31-0927005a-d83c-4bfb-a888-90ebca65f948 ; 0927005a-d83c-4bfb-a888-90ebca65f948 ; urn:nbn:nl:ui:31-0927005a-d83c-4bfb-a888-90ebca65f948 ; https://research.vumc.nl/en/publications/0927005a-d83c-4bfb-a888-90ebca65f948.

MLA Handbook (7^th Edition):

Kamphuis, E I. “Preterm birth: Recurrence and risks of routine interventions.” 2019. Web. 22 Apr 2021.

Vancouver:

Kamphuis EI. Preterm birth: Recurrence and risks of routine interventions. [Internet] [Doctoral dissertation]. NARCIS; 2019. [cited 2021 Apr 22]. Available from: https://research.vumc.nl/en/publications/0927005a-d83c-4bfb-a888-90ebca65f948 ; urn:nbn:nl:ui:31-0927005a-d83c-4bfb-a888-90ebca65f948 ; 0927005a-d83c-4bfb-a888-90ebca65f948 ; urn:nbn:nl:ui:31-0927005a-d83c-4bfb-a888-90ebca65f948 ; https://research.vumc.nl/en/publications/0927005a-d83c-4bfb-a888-90ebca65f948.

Council of Science Editors:

Kamphuis EI. Preterm birth: Recurrence and risks of routine interventions. [Doctoral Dissertation]. NARCIS; 2019. Available from: https://research.vumc.nl/en/publications/0927005a-d83c-4bfb-a888-90ebca65f948 ; urn:nbn:nl:ui:31-0927005a-d83c-4bfb-a888-90ebca65f948 ; 0927005a-d83c-4bfb-a888-90ebca65f948 ; urn:nbn:nl:ui:31-0927005a-d83c-4bfb-a888-90ebca65f948 ; https://research.vumc.nl/en/publications/0927005a-d83c-4bfb-a888-90ebca65f948

University of New South Wales

22. Hossain, Sadia. Neonatal Intensive Care Unit Outcomes of Very Preterm Infants in Australia, New Zealand and Canada.

Degree: Women's & Children's Health, 2015, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/55128 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36582/SOURCE02?view=true

► Very preterm infants, born less than 32 weeks gestation, have a high rate of in-hospital mortality and both short term and long term morbidities. A… (more)

▼ Very preterm infants, born less than 32 weeks gestation, have a high rate of in-hospital mortality and both short term and long term morbidities. A rising rate of preterm births worldwide means outcome improvement of these vulnerable infants is a healthcare priority. International comparison and benchmarking of NICU outcomes between high achieving countries can set standards for very preterm care and evaluate effects of quality–improvement initiatives. The aim of this thesis was to provide a comprehensive comparison of NICU outcomes of very preterm infants born in Australia-New Zealand and Canada, for benchmarking purpose. We utilised data from the Australian and New Zealand Neonatal Network (ANZNN) and Canadian Neonatal Network (CNN) to investigate the research questions. Study 1 was an overview of ANZNN and CNN. Despite demographic and healthcare system similarities between Canada and Australia and New Zealand, very premature infants admitted to the ANZNN after adjustment for confounding variables were 30% less likely to develop severe neurological injury (SNI), retinopathy of prematurity (ROP), necrotising enterocolitis (NEC) or chronic lung disease (CLD).Study 2 was an outcome comparison of inborn and outborn infants as defined by births in tertiary perinatal units. ANZNN had fewer outborns and lower morbidity rates in both inborn and outborn population than CNN. CNN outborn infants admitted from Level II units were more likely to be admitted later possibly due to subsequent surgical needs. CNN outborns after risk adjustments did not have less favourable outcomes, while CNN inborn had more major neonatal morbidities when compared with ANZNN counterparts. Study 3 was designed to investigate any change in NICU outcomes in ANZNN and CNN over 6 years. We found, even though ANZNN continued to have better outcomes, CNN had significant improvements in SNI and ROP rates but there was no change in these measures in ANZNN. In the 6 years of risk adjusted outcomes, ANZNN infants had an increase in both CLD and composite adverse outcome rates while CNN infants had a decrease. We suggest the more evident outcome improvement trends in CNN may be a result of their EPIQ initiatives. In conclusion, we found better outcomes in Australia–New Zealand along with indications of a more regionalised very preterm care in this region. However, we found CNN NICU outcomes are improving at a greater rate than ANZNN. We postulate the proactive quality–improvement initiatives in CNN may have been the primary reason of the improved outcomes in CNN. Furthermore, we propose that the overall better outcomes in ANZNN could similarly be improved. Greater international collaborative and benchmarking initiatives may lead to outcome improvements worldwide. Advisors/Committee Members: Lui, Kei, Faculty of Medicine, UNSW.

Subjects/Keywords: ANZNN; NICU; Quality Improvement; CNN; Very Preterm; Extremely Preterm; Neonatology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hossain, S. (2015). Neonatal Intensive Care Unit Outcomes of Very Preterm Infants in Australia, New Zealand and Canada. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/55128 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36582/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Hossain, Sadia. “Neonatal Intensive Care Unit Outcomes of Very Preterm Infants in Australia, New Zealand and Canada.” 2015. Doctoral Dissertation, University of New South Wales. Accessed April 22, 2021. http://handle.unsw.edu.au/1959.4/55128 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36582/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Hossain, Sadia. “Neonatal Intensive Care Unit Outcomes of Very Preterm Infants in Australia, New Zealand and Canada.” 2015. Web. 22 Apr 2021.

Vancouver:

Hossain S. Neonatal Intensive Care Unit Outcomes of Very Preterm Infants in Australia, New Zealand and Canada. [Internet] [Doctoral dissertation]. University of New South Wales; 2015. [cited 2021 Apr 22]. Available from: http://handle.unsw.edu.au/1959.4/55128 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36582/SOURCE02?view=true.

Council of Science Editors:

Hossain S. Neonatal Intensive Care Unit Outcomes of Very Preterm Infants in Australia, New Zealand and Canada. [Doctoral Dissertation]. University of New South Wales; 2015. Available from: http://handle.unsw.edu.au/1959.4/55128 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36582/SOURCE02?view=true

Oklahoma State University

23. Simpson, Shelby Dederick. High Protein Preterm Formula: Effect on Growth and Outcomes in Preterm Infants Admitted to the Neonatal Intensive Care Unit.

Degree: Department of Nutritional Sciences, 2012, Oklahoma State University

URL: http://hdl.handle.net/11244/9282

► The purpose of this study was to evaluate if increasing the amount of protein provided to preterm infants improved growth and blood urea nitrogen levels… (more)

▼ The purpose of this study was to evaluate if increasing the amount of protein provided to preterm infants improved growth and blood urea nitrogen levels without adverse outcomes. Additional expected outcomes were a decrease in infants with extrauterine growth restriction. Adverse outcomes such as length of stay, incidence of necrotizing enterocolitis, sepsis and mortality were also assessed. The design of the study was a retrospective chart review utilizing a convenience sample from a local hospital's neonatal intensive care unit. The hospital had recently changed from a traditional formula to a higher protein formula. Singleton infants with a birth weight between 600 and 2500 grams and gestation at birth >24 to <37 weeks, admitted to the NICU during the six months prior to the unit's transition to high protein formula in December 2010 and six months after the transition were included. Differences in extrauterine growth restriction and adverse outcomes were assessed by t- tests or chi-square. Hierarchical linear modeling was used to assess the primary hypothesis of differences in weight gain and blood urea nitrogen between groups. Infants in both the traditional formula group (n= 60) and the high protein formula group (n = 54) were similar with the majority of infants being classified as white with a mean gestational age of ~31 weeks. There was an improvement in growth of 8.4 grams per day with every day an infant remained on the higher protein product. There was also an increase in BUN of 0.16 mg/dL for every day an infant received the higher protein preterm formula. The infants in the traditional preterm formula group were discharged at a higher weight (p=.014), but were also admitted to the unit for 11 days more on average (p= .10). Sepsis was diagnosed more frequently in the traditional preterm formula group (p= .08). The higher protein formula lead to better daily growth and improvements in blood urea nitrogen, a measure of protein status. The higher protein product did not increase adverse outcomes, but did demonstrate clinically important trends toward decreased incidence of sepsis, and shortened length of stay.

Subjects/Keywords: blood urea nitrogen; high protein formula; preterm infant growth; preterm infants

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APA (6^th Edition):

Simpson, S. D. (2012). High Protein Preterm Formula: Effect on Growth and Outcomes in Preterm Infants Admitted to the Neonatal Intensive Care Unit. (Thesis). Oklahoma State University. Retrieved from http://hdl.handle.net/11244/9282

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Simpson, Shelby Dederick. “High Protein Preterm Formula: Effect on Growth and Outcomes in Preterm Infants Admitted to the Neonatal Intensive Care Unit.” 2012. Thesis, Oklahoma State University. Accessed April 22, 2021. http://hdl.handle.net/11244/9282.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Simpson, Shelby Dederick. “High Protein Preterm Formula: Effect on Growth and Outcomes in Preterm Infants Admitted to the Neonatal Intensive Care Unit.” 2012. Web. 22 Apr 2021.

Vancouver:

Simpson SD. High Protein Preterm Formula: Effect on Growth and Outcomes in Preterm Infants Admitted to the Neonatal Intensive Care Unit. [Internet] [Thesis]. Oklahoma State University; 2012. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/11244/9282.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Simpson SD. High Protein Preterm Formula: Effect on Growth and Outcomes in Preterm Infants Admitted to the Neonatal Intensive Care Unit. [Thesis]. Oklahoma State University; 2012. Available from: http://hdl.handle.net/11244/9282

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

24. Lawson, Matthew J. The Role of Inflammation in the Pathogenesis of Preterm Birth.

Degree: MS, Medicine: Molecular, Cellular and Biochemical Pharmacology, 2017, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1511861461945183

► Preterm birth (PTB) is a worldwide problem and accounts for nearly 1 million infant deaths each year. Preterm birth is a leading cause of neonatal… (more)

▼ Preterm birth (PTB) is a worldwide problem and accounts for nearly 1 million infant deaths each year. Preterm birth is a leading cause of neonatal morbidity and mortality. Infants born preterm are at an increased risk for many health complications including respiratory distress syndrome, necrotizing enterocolitis, cerebral palsy as well as developmental delays. Rates of PTB vary across the globe, from as low as 5% in Belarus, to as high as 18% in Malawi. Preterm birth is a problem for developed nations as well, for instance the PTB rate in the United States is reported to be 9.6%. The mechanisms underlying PTB are multifaceted and not well understood. It is known however that factors including maternal age, interpregnancy interval, maternal smoking, maternal weight, and race all are associated with PTB. With the paucity of knowledge on the mechanisms of PTB, it is not surprising that few successful preventative therapies exist yet. Notably, infection has been associated with over 40% of cases of PTB. During influenza pandemics pregnant women are at a significantly increased risk compared to others. Additionally, influenza virus has been linked to cases of PTB, and in fact, flu vaccination is considered to have a protective role in preventing PTB. Bacteria and viruses have both been detected in the reproductive tissues of women with PTB. The mechanisms by which infectious pathogens can induce PTB however, are not well understood. However, the innate immune system, the first line of defense against infection, has been implicated as having a potential role in infection driven PTB. The Toll-like receptors (TLR), pathogen-sensing receptors of the innate immune system, are expressed in the reproductive tissue of pregnant women and in fact play a role in the onset of on-time parturition. Activation of TLRs by infectious pathogens has been associated with induction of uterine inflammation and PTB. However, the mechanisms and regulators of these responses, as well as the contribution of specific pathogens to inducing PTB through these receptors is not well understood.Utilizing mouse and non-human primates models, we investigated 1) the downstream regulators and critical compartments of several TLRs in the pathogenesis of PTB; 2) the competency of various TLR ligands to induce PTB, 3) the identification of the immune mediators driving subclinical infection sensitization to inflammation induced PTB. Collectively, our data demonstrate the following: 1) The type I IFN axis plays a critical role in the inflammatory response of TLR2 and TLR4 as well as the induction of PTB in TLR2 and TLR4; 2) Type I Interferon, and specifically IFN-ß, induction by pathogens can prime for a secondary inflammatory challenge to induce PTB; 3) The magnitude TLR2 induced inflammatory response and subsequent PTB is dependent on the specific ligand detected; 4) Maternal TLR4 expression on hematopoietic cells is required for induction of TLR4 induced PTB. These studies demonstrate that TLR activation by infectious pathogens plays a role in… Advisors/Committee Members: Divanovic, Senad (Committee Chair).

Subjects/Keywords: Immunology; Preterm Birth; Inflammation; TLR; Infection; Preterm Labor

12 more images…

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APA (6^th Edition):

Lawson, M. J. (2017). The Role of Inflammation in the Pathogenesis of Preterm Birth. (Masters Thesis). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1511861461945183

Chicago Manual of Style (16^th Edition):

Lawson, Matthew J. “The Role of Inflammation in the Pathogenesis of Preterm Birth.” 2017. Masters Thesis, University of Cincinnati. Accessed April 22, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1511861461945183.

MLA Handbook (7^th Edition):

Lawson, Matthew J. “The Role of Inflammation in the Pathogenesis of Preterm Birth.” 2017. Web. 22 Apr 2021.

Vancouver:

Lawson MJ. The Role of Inflammation in the Pathogenesis of Preterm Birth. [Internet] [Masters thesis]. University of Cincinnati; 2017. [cited 2021 Apr 22]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1511861461945183.

Council of Science Editors:

Lawson MJ. The Role of Inflammation in the Pathogenesis of Preterm Birth. [Masters Thesis]. University of Cincinnati; 2017. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1511861461945183

25. Kamphuis, E.I. Preterm birth: Recurrence and risks of routine interventions.

Degree: 2019, NARCIS

URL: https://research.vu.nl/en/publications/58b558c5-e8ac-44f1-a0df-9134956655de ; urn:nbn:nl:ui:31-58b558c5-e8ac-44f1-a0df-9134956655de ; 58b558c5-e8ac-44f1-a0df-9134956655de ; 1871.1/58b558c5-e8ac-44f1-a0df-9134956655de ; urn:isbn:9789463754576 ; urn:nbn:nl:ui:31-58b558c5-e8ac-44f1-a0df-9134956655de ; https://research.vu.nl/en/publications/58b558c5-e8ac-44f1-a0df-9134956655de

Subjects/Keywords: preterm birth; recurrent preterm birth

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kamphuis, E. I. (2019). Preterm birth: Recurrence and risks of routine interventions. (Doctoral Dissertation). NARCIS. Retrieved from https://research.vu.nl/en/publications/58b558c5-e8ac-44f1-a0df-9134956655de ; urn:nbn:nl:ui:31-58b558c5-e8ac-44f1-a0df-9134956655de ; 58b558c5-e8ac-44f1-a0df-9134956655de ; 1871.1/58b558c5-e8ac-44f1-a0df-9134956655de ; urn:isbn:9789463754576 ; urn:nbn:nl:ui:31-58b558c5-e8ac-44f1-a0df-9134956655de ; https://research.vu.nl/en/publications/58b558c5-e8ac-44f1-a0df-9134956655de

Chicago Manual of Style (16^th Edition):

Kamphuis, E I. “Preterm birth: Recurrence and risks of routine interventions.” 2019. Doctoral Dissertation, NARCIS. Accessed April 22, 2021. https://research.vu.nl/en/publications/58b558c5-e8ac-44f1-a0df-9134956655de ; urn:nbn:nl:ui:31-58b558c5-e8ac-44f1-a0df-9134956655de ; 58b558c5-e8ac-44f1-a0df-9134956655de ; 1871.1/58b558c5-e8ac-44f1-a0df-9134956655de ; urn:isbn:9789463754576 ; urn:nbn:nl:ui:31-58b558c5-e8ac-44f1-a0df-9134956655de ; https://research.vu.nl/en/publications/58b558c5-e8ac-44f1-a0df-9134956655de.

MLA Handbook (7^th Edition):

Kamphuis, E I. “Preterm birth: Recurrence and risks of routine interventions.” 2019. Web. 22 Apr 2021.

Vancouver:

Kamphuis EI. Preterm birth: Recurrence and risks of routine interventions. [Internet] [Doctoral dissertation]. NARCIS; 2019. [cited 2021 Apr 22]. Available from: https://research.vu.nl/en/publications/58b558c5-e8ac-44f1-a0df-9134956655de ; urn:nbn:nl:ui:31-58b558c5-e8ac-44f1-a0df-9134956655de ; 58b558c5-e8ac-44f1-a0df-9134956655de ; 1871.1/58b558c5-e8ac-44f1-a0df-9134956655de ; urn:isbn:9789463754576 ; urn:nbn:nl:ui:31-58b558c5-e8ac-44f1-a0df-9134956655de ; https://research.vu.nl/en/publications/58b558c5-e8ac-44f1-a0df-9134956655de.

Council of Science Editors:

Kamphuis EI. Preterm birth: Recurrence and risks of routine interventions. [Doctoral Dissertation]. NARCIS; 2019. Available from: https://research.vu.nl/en/publications/58b558c5-e8ac-44f1-a0df-9134956655de ; urn:nbn:nl:ui:31-58b558c5-e8ac-44f1-a0df-9134956655de ; 58b558c5-e8ac-44f1-a0df-9134956655de ; 1871.1/58b558c5-e8ac-44f1-a0df-9134956655de ; urn:isbn:9789463754576 ; urn:nbn:nl:ui:31-58b558c5-e8ac-44f1-a0df-9134956655de ; https://research.vu.nl/en/publications/58b558c5-e8ac-44f1-a0df-9134956655de

Universiteit Utrecht

26. Zielman, M. Warming up for temperature control of vulnerable preterm infants A mixed method study about the applied interventions in case of a perceived hypo- or hyperthermia in preterm infants < 30 weeks gestational age.

Degree: 2014, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/296131

► English abstract Introduction: Temperature regulation in preterm infants, especially below 30 weeks gestational age (GA), is a risk factor for complications, caused by temperature fluctuations.… (more)

▼ English abstract Introduction: Temperature regulation in preterm infants, especially below 30 weeks gestational age (GA), is a risk factor for complications, caused by temperature fluctuations. Literature about applied interventions by neonatal nurses regarding temperature regulation of preterm infants is lacking and no guideline exists at the neonatal intensive care unit (NICU) under study. Aim: The aim of this study was to clarify the current operations at the NICU regarding temperature regulation in preterm infants below 30 weeks GA. Research questions: - What is the incidence of hypo- and hyperthermia over a year in preterm infants below 30 weeks GA? - Which interventions are applied by NICU nurses in case of a perceived hypo- or hyperthermia in preterm neonates below 30 weeks GA and which arguments do nurses mention to substantiate their way of handling? Method: To answer these questions a mixed method study design was carried out at the NICU of a University Medical Centre (UMC) in The Netherlands. Quantitative data was gathered from patient files and qualitative data by semi-structured interviews. The study- population consisted of 107 preterm infants below 30 weeks GA and inborn in 2013 and five staff nurses of the NICU. Results: A significant correlation was found between birth weight and the presence of hypothermia (p < .05). Nurses mentioned different applied interventions, but extra attention was paid to the smallest infants. Arguments for their way of handling were mainly based on intuition, taken into account context factors like recent happenings and the trend of the temperature. Conclusion and recommendations: No unequivocal way of handling is carried out by nurses in case of a perceived hypo- or hyperthermia, so further research about the effectiveness of interventions regarding temperature regulation in this vulnerable population is recommended. Dutch summary/ Nederlandse samenvatting Titel: Opwarmen voor de temperatuur bewaking van kwetsbare preterme neonaten. Introductie: Temperatuurregulatie bij preterme neonaten, met name onder de 30 weken zwangerschapsduur, is een risicofactor voor het oplopen van complicaties, veroorzaakt door temperatuurfluctuaties. Literatuur over de door verpleegkundigen toe te passen interventies bij temperatuurfluctuaties mist en ook bestaat er op de neonatologie intensive care unit (NICU) uit deze studie, geen protocol. Doel: Het doel van deze studie was het in kaart brengen van de huidige werkwijze op de NICU omtrent temperatuurregulatie van preterme neonaten onder de 30 weken zwangerschapsduur. Onderzoeksvragen: - Wat is de incidentie van hypo- en hyperthermie gemeten over een jaar bij preterme neonaten onder de 30 weken zwangerschapsduur? - Welke interventies worden toegepast door NICU verpleegkundigen in het geval van een geconstateerde hypo- of hyperthermie bij preterme neonaten onder de 30 weken zwangerschapsduur en welke argumenten benoemen verpleegkundigen voor hun handelswijze? Methode: Om deze onderzoeksvragen te beantwoorden werd een mixed- method… Advisors/Committee Members: Brouwer, A.J..

Subjects/Keywords: English: preterm infant; preterm neonate; temperature; hypothermia; hyperthermia Dutch: preterm kind; preterme neonaat; temperatuur; hypothermie; hyperthermie

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APA (6^th Edition):

Zielman, M. (2014). Warming up for temperature control of vulnerable preterm infants A mixed method study about the applied interventions in case of a perceived hypo- or hyperthermia in preterm infants < 30 weeks gestational age. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/296131

Chicago Manual of Style (16^th Edition):

Zielman, M. “Warming up for temperature control of vulnerable preterm infants A mixed method study about the applied interventions in case of a perceived hypo- or hyperthermia in preterm infants < 30 weeks gestational age.” 2014. Masters Thesis, Universiteit Utrecht. Accessed April 22, 2021. http://dspace.library.uu.nl:8080/handle/1874/296131.

MLA Handbook (7^th Edition):

Zielman, M. “Warming up for temperature control of vulnerable preterm infants A mixed method study about the applied interventions in case of a perceived hypo- or hyperthermia in preterm infants < 30 weeks gestational age.” 2014. Web. 22 Apr 2021.

Vancouver:

Zielman M. Warming up for temperature control of vulnerable preterm infants A mixed method study about the applied interventions in case of a perceived hypo- or hyperthermia in preterm infants < 30 weeks gestational age. [Internet] [Masters thesis]. Universiteit Utrecht; 2014. [cited 2021 Apr 22]. Available from: http://dspace.library.uu.nl:8080/handle/1874/296131.

Council of Science Editors:

Zielman M. Warming up for temperature control of vulnerable preterm infants A mixed method study about the applied interventions in case of a perceived hypo- or hyperthermia in preterm infants < 30 weeks gestational age. [Masters Thesis]. Universiteit Utrecht; 2014. Available from: http://dspace.library.uu.nl:8080/handle/1874/296131

University of Alberta

27. Reichert, Amber E. Evaluation of the Local Incidence and Determinants of Bronchopulmonary Dysplasia and Pulmonary Morbidity in Extremely Preterm Infants.

Degree: MS, Department of Public Health Sciences, 2014, University of Alberta

URL: https://era.library.ualberta.ca/files/cc08hj10c

► Prevention and management of bronchopulmonary dysplasia (BPD) and resulting pulmonary morbidity remains one of the greatest challenges of neonatal intensive care. This study of infants… (more)

▼ Prevention and management of bronchopulmonary dysplasia (BPD) and resulting pulmonary morbidity remains one of the greatest challenges of neonatal intensive care. This study of infants from northern and central Alberta had three goals: first, to estimate the incidence and risk factors contributing to the development of BPD; second, to estimate the incidence and risk factors contributing to the development of pulmonary morbidity in early infancy; and third, to evaluate the use of two specific early scoring systems in the prediction of BPD and early pulmonary morbidity. Methods: This observational prospective study was conducted on a cohort of 103 premature infants born at 30% oxygen was needed, the infant required ventilator support at 36 weeks post-menstrual age or oxygen support was required at hospital discharge. Maternal, antenatal and post-natal risk factors, including two pulmonary scoring systems: the Chronic Oxygen Dependency (COD) Score and the Pulmonary Severity (PS) Score, were evaluated by logistic regression in the prediction of BPD and pulmonary morbidity in early infancy. Infants in this cohort were evaluated for the presence of major pulmonary morbidity in the first 6 months post-discharge, including 1) death from a pulmonary cause; 2) pneumonia or sepsis with a positive blood culture or requiring antibiotics for 5 days or more; 3) continued hospitalization or rehospitalization for a pulmonary cause; 4) continued use of oxygen, diuretics or systemic steroids for pulmonary disease; or 5) use of pulmonary medications, including systemic or inhaled bronchodilators and/or corticosteroids or leukotriene receptor antagonists. Results: Overall incidence of moderate to severe BPD was 44.7%. In the univariate analysis, significant risk factors included lower gestational age, birth weight and male gender. Apgar scores at 1 and 5 minutes were significantly lower for infants developing moderate or severe BPD and these infants were significantly less likely to have received antenatal corticosteroids. When controlling for antenatal and postnatal variables, such as duration of ventilation and presence of retinopathy of prematurity, pulmonary scores applied at days 2 and 7 were not significantly associated with the development of BPD. Overall, at 3 months 20.5% of infants were reported as having one or more of the above morbidities. Similarly, 24.5% of infants with six-month follow-up data were reported as having one or more of the above morbidities. In the multivariate analysis, risk factors associated with pulmonary morbidity at six months corrected age included the presence of moderate to severe BPD, younger maternal age, duration of invasive and non-invasive ventilation, COD score at day 7 and history of atopy. The COD and PS scores were significant predictors of pulmonary morbidity at 6 months corrected age, but the prediction improved when applied at 2 days of age compared with scoring at day 7, however the prediction of pulmonary morbidity was not significant at 6 months when controlling for other risk factors.…

Subjects/Keywords: Bronchopulmonary Dysplasia; Pulmonary Morbidity; Extremely Preterm Infant

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Reichert, A. E. (2014). Evaluation of the Local Incidence and Determinants of Bronchopulmonary Dysplasia and Pulmonary Morbidity in Extremely Preterm Infants. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/cc08hj10c

Chicago Manual of Style (16^th Edition):

Reichert, Amber E. “Evaluation of the Local Incidence and Determinants of Bronchopulmonary Dysplasia and Pulmonary Morbidity in Extremely Preterm Infants.” 2014. Masters Thesis, University of Alberta. Accessed April 22, 2021. https://era.library.ualberta.ca/files/cc08hj10c.

MLA Handbook (7^th Edition):

Reichert, Amber E. “Evaluation of the Local Incidence and Determinants of Bronchopulmonary Dysplasia and Pulmonary Morbidity in Extremely Preterm Infants.” 2014. Web. 22 Apr 2021.

Vancouver:

Reichert AE. Evaluation of the Local Incidence and Determinants of Bronchopulmonary Dysplasia and Pulmonary Morbidity in Extremely Preterm Infants. [Internet] [Masters thesis]. University of Alberta; 2014. [cited 2021 Apr 22]. Available from: https://era.library.ualberta.ca/files/cc08hj10c.

Council of Science Editors:

Reichert AE. Evaluation of the Local Incidence and Determinants of Bronchopulmonary Dysplasia and Pulmonary Morbidity in Extremely Preterm Infants. [Masters Thesis]. University of Alberta; 2014. Available from: https://era.library.ualberta.ca/files/cc08hj10c

Royal Holloway, University of London

28. Sanderson, Charlotte. Early detection of autism spectrum symptomatology in very preterm infants.

Degree: Thesis (D.Clin.Psy.), 2016, Royal Holloway, University of London

URL: https://pure.royalholloway.ac.uk/portal/en/publications/early-detection-of-autism-spectrum-symptomatology-in-very-preterm-infants(e4fddff7-1c42-41d3-8ab9-b12a10879efd).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.792522

► Children born very preterm (VP) are at an increased risk for a wide range of neurodevelopmental impairments, including autism spectrum disorder (ASD) and related symptomatology.… (more)

▼ Children born very preterm (VP) are at an increased risk for a wide range of neurodevelopmental impairments, including autism spectrum disorder (ASD) and related symptomatology. The present thesis investigated early behavioural markers for ASD in VP infants. Using a prospective, longitudinal design, three early infancy markers which have been linked to ASD outcomes in other high-risk groups were investigated: the Autism Observation Scale for Infants (Bryson, Zwaigenbaum, Mcdermott, Rombough, & Brian, 2008), a disengagement of visual attention task (Mayada Elsabbagh, Fernandes, et al., 2013) and infant temperament profiles (Putnam, Helbig, Gartstein, Rothbart, & Leerkes, 2014). Existing data from 65 full term and 41 VP infants at 6 and 12 months was collated, audited and examined using a series of bivariate and multivariate analyses. A sub-set of these infants were followed up at 30-34 months to estimate associations with ASD outcomes, as indicated by the Autism Diagnostic Observation Schedule (ADOS II) (Lord et al., 2012). VP infants showed greater impairment on the AOSI, a behavioural assessment of multiple ASD markers, compared to full-term controls at both 6 and 12 months. These impairments appeared to be independent of developmental delays. AOSI scores at 12 months also showed association with ASD outcomes at 30-34 months. VP infants were also rated by their parents as showing more negative affect during the first year of life, though no association with ASD outcomes was observed. These findings are discussed in relation to the wider literature on early detection in ASD. In particular, the likelihood of heterogeneity in early trajectories towards ASD symptoms is discussed. Multiple marker assessments like the AOSI may be particularly useful tools for detecting ASD symptomatology earlier in high-risk infant populations, in order to enable earlier targeted intervention. Future research may consider the longer-term stability of these early profiles in VP infants, and explore specific biological and psychosocial risk factors for emerging ASD symptomatology in this group.

Subjects/Keywords: Preterm; Autism; ASD; autism spectrum disorder; infant

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APA (6^th Edition):

Sanderson, C. (2016). Early detection of autism spectrum symptomatology in very preterm infants. (Doctoral Dissertation). Royal Holloway, University of London. Retrieved from https://pure.royalholloway.ac.uk/portal/en/publications/early-detection-of-autism-spectrum-symptomatology-in-very-preterm-infants(e4fddff7-1c42-41d3-8ab9-b12a10879efd).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.792522

Chicago Manual of Style (16^th Edition):

Sanderson, Charlotte. “Early detection of autism spectrum symptomatology in very preterm infants.” 2016. Doctoral Dissertation, Royal Holloway, University of London. Accessed April 22, 2021. https://pure.royalholloway.ac.uk/portal/en/publications/early-detection-of-autism-spectrum-symptomatology-in-very-preterm-infants(e4fddff7-1c42-41d3-8ab9-b12a10879efd).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.792522.

MLA Handbook (7^th Edition):

Sanderson, Charlotte. “Early detection of autism spectrum symptomatology in very preterm infants.” 2016. Web. 22 Apr 2021.

Vancouver:

Sanderson C. Early detection of autism spectrum symptomatology in very preterm infants. [Internet] [Doctoral dissertation]. Royal Holloway, University of London; 2016. [cited 2021 Apr 22]. Available from: https://pure.royalholloway.ac.uk/portal/en/publications/early-detection-of-autism-spectrum-symptomatology-in-very-preterm-infants(e4fddff7-1c42-41d3-8ab9-b12a10879efd).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.792522.

Council of Science Editors:

Sanderson C. Early detection of autism spectrum symptomatology in very preterm infants. [Doctoral Dissertation]. Royal Holloway, University of London; 2016. Available from: https://pure.royalholloway.ac.uk/portal/en/publications/early-detection-of-autism-spectrum-symptomatology-in-very-preterm-infants(e4fddff7-1c42-41d3-8ab9-b12a10879efd).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.792522

29. Costa De Freitas, Aline 1987-. Characterization of the vaginal microbiome in pregnancy.

Degree: 2018, University of Saskatchewan

URL: http://hdl.handle.net/10388/8443

► The vaginal microbiome plays an important role in women's reproductive health. Imbalances in this microbiota are associated with bacterial vaginosis, increased susceptibility to sexually transmitted… (more)

▼ The vaginal microbiome plays an important role in women's reproductive health. Imbalances in this microbiota are associated with bacterial vaginosis, increased susceptibility to sexually transmitted infections, and negative reproductive outcomes. The causes of such variations, however, are poorly understood. A healthy vaginal microbiota is defined as Lactobacillus-dominated and an overgrowth of other species is often associated with unhealthy conditions. An appreciation of "atypical" microbiomes in healthy women, such as Bifidobacterium-dominated, has been gradually increasing. Although bifidobacteria play an important role in gut health, vaginal bifidobacteria have not yet been fully characterized. In this study, a baseline description of the "healthy" vaginal microbiome in pregnancy has been established based on cpn60 gene amplicon sequencing. The vaginal microbiota of pregnant women relative to non-pregnant women had lower richness and diversity, higher Lactobacillus abundance and lower Mollicutes/Ureaplasma prevalence. This gives a better understanding of the vaginal microbiome in healthy pregnancies and provides a control group for a subsequent comparison to women who experienced preterm birth. An association between Mollicutes and preterm was confirmed, and further suggested that a more rich and diverse microbiome is associated with prematurity. To better understand the relationship between reproductive outcomes and microbiota, an improved definition of the healthy microbiome is also needed, which should include evaluation of "atypical" microbiomes, such as Bifidobacterium-dominated. Phenotypic characterization of vaginal bifidobacteria indicated that they have health promoting characteristics similar to beneficial vaginal lactobacilli. Considering the importance of bifidobacteria as one of the primary colonizers of the neonatal gut, the genomes of vaginal and gut isolates of Bifidobacterium breve and Bifidobacterium longum were compared. Results indicated that vaginal and gut microbiomes are colonized by a shared community of Bifidobacterium, which may be transferred from mother to infant. Taken together, the results presented in this thesis provide a better understanding of the vaginal microbiome of pregnant women with low and high risk for preterm birth. It also improves the understanding of a healthy microbiome by phenotypically characterizing vaginal bifidobacteria, and contributes to elucidate aspects of bifidobacteria ecology by comparing the genomes of vaginal and gut bifidobacteria. Advisors/Committee Members: Hill, Janet E, Misra, Vikram, Rubin, Joseph, White, Aaron, Dilon, Jo-Anne.

Subjects/Keywords: Vaginal microbiome; pregnancy; bifidobacteria; genome; preterm birth

10 more images…

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APA (6^th Edition):

Costa De Freitas, A. 1. (2018). Characterization of the vaginal microbiome in pregnancy. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/8443

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Costa De Freitas, Aline 1987-. “Characterization of the vaginal microbiome in pregnancy.” 2018. Thesis, University of Saskatchewan. Accessed April 22, 2021. http://hdl.handle.net/10388/8443.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Costa De Freitas, Aline 1987-. “Characterization of the vaginal microbiome in pregnancy.” 2018. Web. 22 Apr 2021.

Vancouver:

Costa De Freitas A1. Characterization of the vaginal microbiome in pregnancy. [Internet] [Thesis]. University of Saskatchewan; 2018. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/10388/8443.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Costa De Freitas A1. Characterization of the vaginal microbiome in pregnancy. [Thesis]. University of Saskatchewan; 2018. Available from: http://hdl.handle.net/10388/8443

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

30. Vuong, Ann Minh. Prenatal Exposure to Nitrates, Nitrites, and Nitrosatable Drugs and Preterm Births.

Degree: Doctor of Public Health, Epidemiology and Environmental Health, 2013, Texas A&M University

URL: http://hdl.handle.net/1969.1/151795

► Nitrosatable drugs react with nitrite in the stomach to form N-nitroso compounds, observed in animal models to result in adverse pregnancy outcomes such as birth… (more)

▼ Nitrosatable drugs react with nitrite in the stomach to form N-nitroso compounds, observed in animal models to result in adverse pregnancy outcomes such as birth defects and reduced fetal weight. Previous studies examining prenatal exposure to medications classified as nitrosatable have observed an increased risk of preterm delivery. Vitamin C is a known nitrosation inhibitor. Using data from mothers (controls) of babies without major birth defects from the National Birth Defects Prevention Study, we examined the relation between preterm births and: 1) prenatal nitrosatable drug usage; 2) dietary intake of nitrates/nitrites; 3) joint exposures to nitrosatable drugs and nitrate/nitrite intake; and 4) nitrosatable drugs and vitamin C intake among 496 case-mothers of preterm infants and 5398 control-mothers who delivered full term babies from 1997-2005. An increased risk of preterm births was observed with secondary amine exposure during the second (adjusted hazard ratio (aHR) 1.37, [95% confidence interval (CI) 1.05, 1.79]) and third (aHR 1.34, [95% CI 1.02, 1.76]) trimester. A protective effect was detected with high levels of plant nitrites (aHR 0.72, [95% CI 0.53, 0.97]). Exposure to secondary amines and high levels of nitrite were associated with preterm births, having an increased risk with first (aHR 1.84, [95% CI 1.14, 2.98]), second (aHR 1.89, [95% CI 1.17, 3.07]), and third (aHR 2.00, [95% CI 1.22, 3.29]) trimester exposure. Lower risk of moderately preterm births was observed with second trimester amide exposure in conjunction with higher levels of dietary vitamin C (aHR 1.14, [95% CI 0.66, 1.98]) compared to <85 mg/day (aHR 2.08, [95% CI 1.25, 3.47]). Prenatal exposure to nitrosatable drugs during the second and third trimester, particularly secondary amines, might increase risk of preterm delivery. In addition, nitrosatable drugs, especially secondary and tertiary amines, and higher levels of dietary nitrite (including animal, plant, and total) may increase risk of preterm births. However, dietary vitamin C intake ≥85 mg/day may attenuate the association between nitrosatable drug use during the second trimester and preterm and moderately preterm births. In this study population, daily vitamin C supplementation did not appear to confer the same benefits. Advisors/Committee Members: Brender, Jean D (advisor), Huber, Jr., John C (committee member), McDonald, Thomas J (committee member), Sharkey, Joseph R (committee member), Shipp, Eva M (committee member).

Subjects/Keywords: preterm births; nitrosatable drugs; nitrate; nitrite

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vuong, A. M. (2013). Prenatal Exposure to Nitrates, Nitrites, and Nitrosatable Drugs and Preterm Births. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/151795

Chicago Manual of Style (16^th Edition):

Vuong, Ann Minh. “Prenatal Exposure to Nitrates, Nitrites, and Nitrosatable Drugs and Preterm Births.” 2013. Doctoral Dissertation, Texas A&M University. Accessed April 22, 2021. http://hdl.handle.net/1969.1/151795.

MLA Handbook (7^th Edition):

Vuong, Ann Minh. “Prenatal Exposure to Nitrates, Nitrites, and Nitrosatable Drugs and Preterm Births.” 2013. Web. 22 Apr 2021.

Vancouver:

Vuong AM. Prenatal Exposure to Nitrates, Nitrites, and Nitrosatable Drugs and Preterm Births. [Internet] [Doctoral dissertation]. Texas A&M University; 2013. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/1969.1/151795.

Council of Science Editors:

Vuong AM. Prenatal Exposure to Nitrates, Nitrites, and Nitrosatable Drugs and Preterm Births. [Doctoral Dissertation]. Texas A&M University; 2013. Available from: http://hdl.handle.net/1969.1/151795

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Open Access Theses and Dissertations