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You searched for subject:(Post surgical analgesia). Showing records 1 – 2 of 2 total matches.

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Dalhousie University

1. Liu, Jean. Further Studies in Adenosinergic and Monoaminergic Mechanisms of Analgesia by Amitriptyline.

Degree: MS, Department of Pharmacology with Neuroscience, 2012, Dalhousie University

In this thesis, rodent models of chronic pain were used to explore analgesic mechanisms that may potentially be engaged in spinal and peripheral compartments by systemically-administered amitriptyline, a tricyclic antidepressant. The first project (Chapter 2) identified the roles of spinal adenosine A1 and serotonin 5-HT7 receptors, as well as of peripheral adenosine A1 receptors, in the acute antinociceptive effects of amitriptyline in mice. The second project (Chapter 3) examined the potential utility of amitriptyline as a preventive analgesic against persistent post-surgical pain, and involved perioperative administration of amitriptyline after peripheral nerve injury in rats. Changes in post-injury behavioural outcomes, as well as spinal noradrenergic sprouting, were assessed. Overall, spinal serotonergic pathways linked to adenosine A1 receptors, as well as peripheral adenosine A1 receptors, appear to be important in antinociception by amitriptyline. Preventive analgesia by this drug does not appear to result from anatomical changes in spinal noradrenergic pathways. Advisors/Committee Members: Kazue Semba (external-examiner), Eileen Denovan-Wright (graduate-coordinator), Jason McDougall (thesis-reader), Jana Sawynok (thesis-supervisor), Received (ethics-approval), Not Applicable (manuscripts), Not Applicable (copyright-release).

Subjects/Keywords: amitriptyline; persistent post-surgical pain; adenosine A1 receptor; serotonin 5-HT7 receptor; formalin test; antinociception; spared nerve injury; preventive analgesia; antidepressants; pain

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Liu, J. (2012). Further Studies in Adenosinergic and Monoaminergic Mechanisms of Analgesia by Amitriptyline. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/15329

Chicago Manual of Style (16th Edition):

Liu, Jean. “Further Studies in Adenosinergic and Monoaminergic Mechanisms of Analgesia by Amitriptyline.” 2012. Masters Thesis, Dalhousie University. Accessed February 25, 2021. http://hdl.handle.net/10222/15329.

MLA Handbook (7th Edition):

Liu, Jean. “Further Studies in Adenosinergic and Monoaminergic Mechanisms of Analgesia by Amitriptyline.” 2012. Web. 25 Feb 2021.

Vancouver:

Liu J. Further Studies in Adenosinergic and Monoaminergic Mechanisms of Analgesia by Amitriptyline. [Internet] [Masters thesis]. Dalhousie University; 2012. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/10222/15329.

Council of Science Editors:

Liu J. Further Studies in Adenosinergic and Monoaminergic Mechanisms of Analgesia by Amitriptyline. [Masters Thesis]. Dalhousie University; 2012. Available from: http://hdl.handle.net/10222/15329

2. Bjerså, Kristofer. Complementary and Alternative Therapies in Surgical Care.

Degree: 2012, University of Gothenburg / Göteborgs Universitet

International and national use of complementary and alternative medicine (CAM) is high in the general population and among patients. The level of knowledge about CAM among health care professions is low, but an interest in receiving education about this field has been observed. Concerning surgical care, previous studies indicate a wide range of CAM use among patients, but the level of knowledge among health care professions is poorly investigated, both internationally and in Sweden. Concerning CAM therapies in the management of signs and symptoms in surgical care, transcutaneous electric nerve stimulation (TENS) was used with a variety of effectiveness and osteopathic medicine was found to be poorly investigated in this context. The overall objective of this thesis was to investigate CAM in the surgical context with a focus on health care professions’ perceptions and understanding and the usefulness of therapy in symptom management in clinical settings. Both inductive (paper I; semi structured interviews, n=16) and deductive (paper II; questionnaire, n=737) methods were used to investigate perceptions and understanding of CAM among Swedish health care professions in surgical care. TENS as a pain relieving complement during the transition from epidural analgesia (EDA) to general analgesia after major abdominal surgery was investigated in a randomized controlled trial design (paper III; n=20). Osteopathic intervention in management of chronic signs and symptoms after thoracotomy was investigated with a single-subject research design (paper IV; n=8). The results reveal that surgical health care professions understand and perceive CAM as a wide range of therapies, remedies and systems. Their self valued level of knowledge was low, both concerning CAM and CAM research, but a desire was found to gain knowledge about CAM. A majority of the participants would consider learning a CAM therapy. Dialog about and referral to CAM occurred, but to a limited extent. Concerning therapy usability, TENS was not found to significantly relieve pain, promote recovery or reduce consumption of analgesics. In addition, comments from nurses and patients indicated that TENS treatment obstructed postoperative care. A significant improvement was observed in the osteopathic intervention in stiffness and benefits for pain, but not in breathing. The comprehensive conclusion of the thesis is that Swedish health care professions recognise the concept of CAM and some of its therapies, but their knowledge is in general low. Concerning therapy usability and the effectiveness of CAM in surgical care, the context is essential; TENS after major abdominal surgery in EDA elimination is questionable as concerns pain and its clinical application, while osteopathy may be beneficial in the management of chronic signs and symptoms after thoracotomy.

Subjects/Keywords: Complementary Therapies; Komplementära terapier; Complementary medicine; Komplementära metoder; Complementary and Alternative medicine (CAM); Komplementär och alternativmedicin (KAM); Surgery; Kirurgi; Surgical Care; Kirurgisk vård; Transcutaneous electric nerve stimulation (TENS); Osteopathic Medicine; Osteopati; Perceptions; Uppfattningar; Knowledge; Kunskap; Epidural Analgesia; Post-thoracic symptoms

…among Swedish registered professions in surgical care. Complementary Therapies in Clinical… …providers in Swedish surgical care: a national survey among university hospitals. BMC… …from epidural to general analgesia after pancreatic resection. Submitted. IV. Bjerså, K… …1.1.3 Surgical care… …surgical care ................................ 17 1.2 Transcutaneous electrical nerve stimulation… 

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Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Bjerså, K. (2012). Complementary and Alternative Therapies in Surgical Care. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/29720

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Bjerså, Kristofer. “Complementary and Alternative Therapies in Surgical Care.” 2012. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed February 25, 2021. http://hdl.handle.net/2077/29720.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Bjerså, Kristofer. “Complementary and Alternative Therapies in Surgical Care.” 2012. Web. 25 Feb 2021.

Vancouver:

Bjerså K. Complementary and Alternative Therapies in Surgical Care. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2012. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/2077/29720.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bjerså K. Complementary and Alternative Therapies in Surgical Care. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2012. Available from: http://hdl.handle.net/2077/29720

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.