subject:(Polyphenols)

University of Georgia

1. Kobs, Lisa Michelle. Dietary polyphenolic intake from acorns and acorn meal.

Degree: MS, Foods and Nutrition, 2008, University of Georgia

URL: http://purl.galileo.usg.edu/uga_etd/kobs_lisa_m_200805_ms

► Antioxidant consumption can increase through strategic food choices. Acorns could contribute to those strategic choices. We surveyed antioxidant content in a variety of acorns from… (more)

Subjects/Keywords: Polyphenols

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kobs, L. M. (2008). Dietary polyphenolic intake from acorns and acorn meal. (Masters Thesis). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/kobs_lisa_m_200805_ms

Chicago Manual of Style (16^th Edition):

Kobs, Lisa Michelle. “Dietary polyphenolic intake from acorns and acorn meal.” 2008. Masters Thesis, University of Georgia. Accessed February 16, 2020. http://purl.galileo.usg.edu/uga_etd/kobs_lisa_m_200805_ms.

MLA Handbook (7^th Edition):

Kobs, Lisa Michelle. “Dietary polyphenolic intake from acorns and acorn meal.” 2008. Web. 16 Feb 2020.

Vancouver:

Kobs LM. Dietary polyphenolic intake from acorns and acorn meal. [Internet] [Masters thesis]. University of Georgia; 2008. [cited 2020 Feb 16]. Available from: http://purl.galileo.usg.edu/uga_etd/kobs_lisa_m_200805_ms.

Council of Science Editors:

Kobs LM. Dietary polyphenolic intake from acorns and acorn meal. [Masters Thesis]. University of Georgia; 2008. Available from: http://purl.galileo.usg.edu/uga_etd/kobs_lisa_m_200805_ms

2. Ritchie, Lauren E. Diet, Disease State, and the Space Environment Modify the Intestinal Microbiota and Mucosal Environment via Microbiota-directed Alterations in Colonocyte Signalling.

Degree: 2013, Texas Digital Library

URL: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66599

► Microbial dysbiosis and toll-like receptor (TLR) signaling play a role in colonic injury and inflammation. Ulcerative colitis and radiation are known to alter microbiota, and… (more)

▼ Microbial dysbiosis and toll-like receptor (TLR) signaling play a role in colonic injury and inflammation. Ulcerative colitis and radiation are known to alter microbiota, and diets containing polyphenols impact bacterial populations. We hypothesized that diet can mitigate dextran sodium sulfate (DSS) colitis (sorghum bran diets containing polyphenols) and space environment-induced alterations (normal iron content) in colonic microbiota and TLR signaling. To test this we utilized two experimental paradigms; DSS-induced colitis (3% DSS, 48-hr, 3 exposures, 2 wk separation), and three models to emulate the space environment: 1) fractionated low linear energy transfer (LET) ?? radiation (RAD) (3 Gy) and high Fe diet (IRON) (650 mg/kg), 2) high LET Si particle exposure (50 cGy) and 1/6 G hind limb unloading (HLU), and 3) 13 d spaceflight. Bran diets upregulated proliferation, and repair protein (TFF3 and TGF??) and short chain fatty acid (SCFA) transporter (Slc16a1 and Slc5a8) expression post-DSS. Diet significantly affected 24-hr fecal butyrate production, with Cellulose and Black bran having numerically higher concentrations. Two predominant phyla were identified, Firmicutes and Bacteroidetes, and this ratio was higher in Cellulose DSS. Post DSS#3 the proportion of Bacteroidales, Clostridiales, and Lactobacillales was reduced compared to post DSS#2 for all diets. Black bran non-DSS rats had the highest richness and diversity. Colonic injury negatively correlated with the proportion of Firmicutes, Actinobacteria, and Lactobacillales, and positively correlated with Unknown and Unclassified groups. Bran diets reduced the severity of epithelial injury, maintained fecal butyrate, and prevented microbial dysbiosis and depletion during DSS-induced colitis. IRON+RAD decreased SCFA concentrations. Low and high LET radiation, HLU, IRON and spaceflight increased Bacteroidetes and decreased Firmicutes. HLU and spaceflight increased Clostridiales and decreased Lactobacillales. RAD and IRON+RAD animals had increased Lactobacillales and significantly lower Clostridiales compared to CON and IRON. TLR9 and IL-6 were downregulated by RAD. TLR4, TFF3 and TGF?? differentially changed with IRON and spaceflight. Microgravity independently affected the microbiota, regardless of radiation energy or dose. Each environmental insult differentially altered the microbiota and mucosal gene expression, with distinct diet, microgravity, and radiation effects observed. Bran diets mitigated deleterious effects of colitis, maintained barrier integrity, and prevented microbiota dysbiosis. Advisors/Committee Members: Turner, Nancy D (advisor).

Subjects/Keywords: polyphenols

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ritchie, L. E. (2013). Diet, Disease State, and the Space Environment Modify the Intestinal Microbiota and Mucosal Environment via Microbiota-directed Alterations in Colonocyte Signalling. (Thesis). Texas Digital Library. Retrieved from http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66599

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ritchie, Lauren E. “Diet, Disease State, and the Space Environment Modify the Intestinal Microbiota and Mucosal Environment via Microbiota-directed Alterations in Colonocyte Signalling.” 2013. Thesis, Texas Digital Library. Accessed February 16, 2020. http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66599.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ritchie, Lauren E. “Diet, Disease State, and the Space Environment Modify the Intestinal Microbiota and Mucosal Environment via Microbiota-directed Alterations in Colonocyte Signalling.” 2013. Web. 16 Feb 2020.

Vancouver:

Ritchie LE. Diet, Disease State, and the Space Environment Modify the Intestinal Microbiota and Mucosal Environment via Microbiota-directed Alterations in Colonocyte Signalling. [Internet] [Thesis]. Texas Digital Library; 2013. [cited 2020 Feb 16]. Available from: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66599.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ritchie LE. Diet, Disease State, and the Space Environment Modify the Intestinal Microbiota and Mucosal Environment via Microbiota-directed Alterations in Colonocyte Signalling. [Thesis]. Texas Digital Library; 2013. Available from: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66599

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Oregon State University

3. Chaovanalikit, Arusa, 1974-. Cherry phytochemicals.

Degree: PhD, Food Science and Technology, 2003, Oregon State University

URL: http://hdl.handle.net/1957/27184

► The distribution of anthocyanin pigments and polyphenolics of sweet (Prunus avium) and sour cherries (Prunus cerasus) were determined by Ultraviolet- Visible (UV-Visible) spectrophotometry and High… (more)

▼ The distribution of anthocyanin pigments and polyphenolics of sweet (Prunus avium) and sour cherries (Prunus cerasus) were determined by Ultraviolet- Visible (UV-Visible) spectrophotometry and High Performance Liquid Chromatography with photodiode array detector (HPLC-DAD). Their antioxidant properties were determined by Oxygen Radical Absorbance Capacity (ORAC) and Ferric Reducing Antioxidant Power (FRAP). The effect of frozen storage, canning, and brining on those properties was measured. Experiments were conducted on three sweet cherry cultivars; Bing, Rainier, Royal Ann and one sour cherry cultivar; Montmorency. Cherries were separated into skins, flesh, pits, and pitted cherries for subsequent analyses. Bing had the highest anthocyanin pigments (60.6 mg/lOOg fw) while Montmorency had both the highest total phenolic content (5.6 mg GAE/g fw) and the highest antioxidant activities (ORAC 51.02 μmoles Trolox equivalent (TE) /g fw, FRAP 47.96 μmoles TE/g fw). Hydroxycinnamates predominated in sweet cherries (70-80%) while flavanols were the major class of polyphenolics in sour cherries (70%). The major anthocyanins in sweet and sour cherries were cyanidin-3-rutinoside and cyanidin-3- glucosylrutinoside, respectively. Skins contained the highest amount of anthocyanins, polyphenolics, and antioxidant activities. Anthocyanins and flavonol glycosides predominated in cherry skins. Bing cherries were different from the others in that it had substantial anthocyanins in flesh and pits. The proportion of flavanols increased from skins to pits. Pitted Bing cherries were frozen and stored at -23 and -70°C for 3 and 6 months. Pitted Bing cherries were also canned in light syrup and stored at 2 and 22°C for 5 months. Both Bing and Royal Ann cherries were brined in bisulfite for one year. In all processing experiments, polyphenolics were more stable than anthocyanins. Degradation of hydroxycinnamates occurred during frozen storage and canning while flavonol glycosides were relatively stable. With both canning and brining, anthocyanins and polyphenolics leached into syrup and brine. With brining, hydroxycinnamates and flavonol glycosides disappeared, and unidentified compounds with UV-Visible spectra similar to flavanols were formed. Unidentified compounds possessed antioxidant activity. Cherry skins are high in anthocyanins, polyphenolics and antioxidant properties. Cherry pits and spent brine solution may be a potential source for natural colorants, nutraceuticals, and natural antioxidants. Advisors/Committee Members: Wrolstad, Ronald E. (advisor), Remcho, Vincent T. (committee member).

Subjects/Keywords: Polyphenols

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chaovanalikit, Arusa, 1. (2003). Cherry phytochemicals. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/27184

Chicago Manual of Style (16^th Edition):

Chaovanalikit, Arusa, 1974-. “Cherry phytochemicals.” 2003. Doctoral Dissertation, Oregon State University. Accessed February 16, 2020. http://hdl.handle.net/1957/27184.

MLA Handbook (7^th Edition):

Chaovanalikit, Arusa, 1974-. “Cherry phytochemicals.” 2003. Web. 16 Feb 2020.

Vancouver:

Chaovanalikit, Arusa 1. Cherry phytochemicals. [Internet] [Doctoral dissertation]. Oregon State University; 2003. [cited 2020 Feb 16]. Available from: http://hdl.handle.net/1957/27184.

Council of Science Editors:

Chaovanalikit, Arusa 1. Cherry phytochemicals. [Doctoral Dissertation]. Oregon State University; 2003. Available from: http://hdl.handle.net/1957/27184

University of Hong Kong

4. 楊傳彬; Yang, Chuanbin. Characterization of the molecular mechanisms underlying the cytotoxicity and neurotrophic activities of caffeic acid derivatives.

Degree: PhD, 2014, University of Hong Kong

URL: Yang, C. [楊傳彬]. (2014). Characterization of the molecular mechanisms underlying the cytotoxicity and neurotrophic activities of caffeic acid derivatives. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5435624 ; http://dx.doi.org/10.5353/th_b5435624 ; http://hdl.handle.net/10722/221655

published_or_final_version

Chinese Medicine

Doctoral

Doctor of Philosophy

Subjects/Keywords: Polyphenols

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

楊傳彬; Yang, C. (2014). Characterization of the molecular mechanisms underlying the cytotoxicity and neurotrophic activities of caffeic acid derivatives. (Doctoral Dissertation). University of Hong Kong. Retrieved from Yang, C. [楊傳彬]. (2014). Characterization of the molecular mechanisms underlying the cytotoxicity and neurotrophic activities of caffeic acid derivatives. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5435624 ; http://dx.doi.org/10.5353/th_b5435624 ; http://hdl.handle.net/10722/221655

Chicago Manual of Style (16^th Edition):

楊傳彬; Yang, Chuanbin. “Characterization of the molecular mechanisms underlying the cytotoxicity and neurotrophic activities of caffeic acid derivatives.” 2014. Doctoral Dissertation, University of Hong Kong. Accessed February 16, 2020. Yang, C. [楊傳彬]. (2014). Characterization of the molecular mechanisms underlying the cytotoxicity and neurotrophic activities of caffeic acid derivatives. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5435624 ; http://dx.doi.org/10.5353/th_b5435624 ; http://hdl.handle.net/10722/221655.

MLA Handbook (7^th Edition):

楊傳彬; Yang, Chuanbin. “Characterization of the molecular mechanisms underlying the cytotoxicity and neurotrophic activities of caffeic acid derivatives.” 2014. Web. 16 Feb 2020.

Vancouver:

楊傳彬; Yang C. Characterization of the molecular mechanisms underlying the cytotoxicity and neurotrophic activities of caffeic acid derivatives. [Internet] [Doctoral dissertation]. University of Hong Kong; 2014. [cited 2020 Feb 16]. Available from: Yang, C. [楊傳彬]. (2014). Characterization of the molecular mechanisms underlying the cytotoxicity and neurotrophic activities of caffeic acid derivatives. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5435624 ; http://dx.doi.org/10.5353/th_b5435624 ; http://hdl.handle.net/10722/221655.

Council of Science Editors:

楊傳彬; Yang C. Characterization of the molecular mechanisms underlying the cytotoxicity and neurotrophic activities of caffeic acid derivatives. [Doctoral Dissertation]. University of Hong Kong; 2014. Available from: Yang, C. [楊傳彬]. (2014). Characterization of the molecular mechanisms underlying the cytotoxicity and neurotrophic activities of caffeic acid derivatives. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5435624 ; http://dx.doi.org/10.5353/th_b5435624 ; http://hdl.handle.net/10722/221655

University of Hong Kong

5. Yang, Chuanbin. Characterization of the molecular mechanisms underlying the cytotoxicity and neurotrophic activities of caffeic acid derivatives.

Degree: PhD, 2014, University of Hong Kong

URL: http://hdl.handle.net/10722/209510

abstract

Chinese Medicine

Doctoral

Doctor of Philosophy

Subjects/Keywords: Polyphenols

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yang, C. (2014). Characterization of the molecular mechanisms underlying the cytotoxicity and neurotrophic activities of caffeic acid derivatives. (Doctoral Dissertation). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/209510

Chicago Manual of Style (16^th Edition):

Yang, Chuanbin. “Characterization of the molecular mechanisms underlying the cytotoxicity and neurotrophic activities of caffeic acid derivatives.” 2014. Doctoral Dissertation, University of Hong Kong. Accessed February 16, 2020. http://hdl.handle.net/10722/209510.

MLA Handbook (7^th Edition):

Yang, Chuanbin. “Characterization of the molecular mechanisms underlying the cytotoxicity and neurotrophic activities of caffeic acid derivatives.” 2014. Web. 16 Feb 2020.

Vancouver:

Yang C. Characterization of the molecular mechanisms underlying the cytotoxicity and neurotrophic activities of caffeic acid derivatives. [Internet] [Doctoral dissertation]. University of Hong Kong; 2014. [cited 2020 Feb 16]. Available from: http://hdl.handle.net/10722/209510.

Council of Science Editors:

Yang C. Characterization of the molecular mechanisms underlying the cytotoxicity and neurotrophic activities of caffeic acid derivatives. [Doctoral Dissertation]. University of Hong Kong; 2014. Available from: http://hdl.handle.net/10722/209510

Oregon State University

6. Miller, Robert J. (Robert James), 1933-. Characterization and applications of polyphenol chemiluminescence reactions and flow cell instrumentation.

Degree: PhD, Chemistry, 1991, Oregon State University

URL: http://hdl.handle.net/1957/37277

Subjects/Keywords: Polyphenols

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Miller, Robert J. (Robert James), 1. (1991). Characterization and applications of polyphenol chemiluminescence reactions and flow cell instrumentation. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/37277

Chicago Manual of Style (16^th Edition):

Miller, Robert J. (Robert James), 1933-. “Characterization and applications of polyphenol chemiluminescence reactions and flow cell instrumentation.” 1991. Doctoral Dissertation, Oregon State University. Accessed February 16, 2020. http://hdl.handle.net/1957/37277.

MLA Handbook (7^th Edition):

Miller, Robert J. (Robert James), 1933-. “Characterization and applications of polyphenol chemiluminescence reactions and flow cell instrumentation.” 1991. Web. 16 Feb 2020.

Vancouver:

Miller, Robert J. (Robert James) 1. Characterization and applications of polyphenol chemiluminescence reactions and flow cell instrumentation. [Internet] [Doctoral dissertation]. Oregon State University; 1991. [cited 2020 Feb 16]. Available from: http://hdl.handle.net/1957/37277.

Council of Science Editors:

Miller, Robert J. (Robert James) 1. Characterization and applications of polyphenol chemiluminescence reactions and flow cell instrumentation. [Doctoral Dissertation]. Oregon State University; 1991. Available from: http://hdl.handle.net/1957/37277

Oregon State University

7. Chen, Jie. Low molecular weight polyphenols in Douglas-fir outer bark : extraction, isolation and structure determination.

Degree: MS, Forest Products, 1991, Oregon State University

URL: http://hdl.handle.net/1957/19784

Subjects/Keywords: Polyphenols

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chen, J. (1991). Low molecular weight polyphenols in Douglas-fir outer bark : extraction, isolation and structure determination. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/19784

Chicago Manual of Style (16^th Edition):

Chen, Jie. “Low molecular weight polyphenols in Douglas-fir outer bark : extraction, isolation and structure determination.” 1991. Masters Thesis, Oregon State University. Accessed February 16, 2020. http://hdl.handle.net/1957/19784.

MLA Handbook (7^th Edition):

Chen, Jie. “Low molecular weight polyphenols in Douglas-fir outer bark : extraction, isolation and structure determination.” 1991. Web. 16 Feb 2020.

Vancouver:

Chen J. Low molecular weight polyphenols in Douglas-fir outer bark : extraction, isolation and structure determination. [Internet] [Masters thesis]. Oregon State University; 1991. [cited 2020 Feb 16]. Available from: http://hdl.handle.net/1957/19784.

Council of Science Editors:

Chen J. Low molecular weight polyphenols in Douglas-fir outer bark : extraction, isolation and structure determination. [Masters Thesis]. Oregon State University; 1991. Available from: http://hdl.handle.net/1957/19784

University of Hong Kong

8. Zhang, Xinchen. Controlling nonenzymatic browning reactions by selected dietary polyphenols in chemical and food models.

Degree: PhD, 2014, University of Hong Kong

URL: Zhang, X. [张忻晨]. (2014). Controlling nonenzymatic browning reactions by selected dietary polyphenols in chemical and food models. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5312328 ; http://dx.doi.org/10.5353/th_b5312328 ; http://hdl.handle.net/10722/219899

► Nonenzymatic browning reactions, which readily proceed with the starting reactants of sugar and protein during thermal processing and storage of food, are of unignorable significance… (more)

▼ Nonenzymatic browning reactions, which readily proceed with the starting reactants of sugar and protein during thermal processing and storage of food, are of unignorable significance to the formation of color, aroma and flavor compounds. In addition to its role in the sensory properties of food, the process also contributes to loss of essential nutrients, generation of beneficial compounds such as antioxidants, as well as production of toxicants, including 5-hydroxymethylfurfural (5-HMF), reactive carbonyl species (glyoxal and methylglyoxal) and advanced glycation end products (AGEs). These exogenous dietary toxicants can enter body circulation after digestion. The absorption, metabolism, and exposure to these toxicants have been found to cause oxidative cell damage, genetic mutation, pathological development of chronic diseases and tumor genesis. Dietary polyphenols from daily food intake have been reported to mitigate the toxicants formation primarily through free radical scavenging and dicarbonyl trapping activities in chemical models under simulated physiological conditions. However, there’s lack of studies on the phenolics’ antioxidant and antiglycation activity under thermal conditions or in real food matrix. The present study aims to evaluate the potential of dietary polyphenols in controlling the thermal proceeding of nonenzymatic browning reactions, specifically on the formation of colorants, antioxidants and toxicants. Six polyphenols commonly present in diet were selected, including phloretin, naringenin, quercetin, epicatechin, chlorogenic acid and rosmarinic acid, which belong to different structural categories. In sugar caramelization model, polyphenols were found to increase the browning intensity and antioxidant capacity of caramel. The chemical reactions in the system of sugar and polyphenol, which include formation of polyphenol-sugar adducts, were suggested to be partially responsible for the formation of brown pigments and heat-induced antioxidants. In addition, rosmarinic acid was demonstrated to significantly inhibit the formation of 5-HMF. When added into the glucose-casein glycation model, polyphenols were capable of inhibiting the formation of both total fluorescent AGEs and nonfluorescent carboxymethyllysine (CML).The thermal stability and transformation of polyphenols was likely an important factor affecting their antioxidant activity and inhibitory efficacy of dicarbonyls formation. We further discovered that treatment with epicatechin would not only lower AGEs formation but AGEs-induced cytotoxicity and oxidative stress to human retinal pigment epithelial (ARPE-19) cells. Finally, the practicality of polyphenols as functional food ingredients was explored in a cookie model. Results indicated that the enhancement on the antioxidant capacity was not as obvious as expected because the phenolics’ antioxidant activity was seriously lowered by the baking process due to thermal degradation and transformation. Meantime, the tested polyphenols, especially quercetin, showed inhibition against…

Subjects/Keywords: Food - Biotechnology; Polyphenols

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zhang, X. (2014). Controlling nonenzymatic browning reactions by selected dietary polyphenols in chemical and food models. (Doctoral Dissertation). University of Hong Kong. Retrieved from Zhang, X. [张忻晨]. (2014). Controlling nonenzymatic browning reactions by selected dietary polyphenols in chemical and food models. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5312328 ; http://dx.doi.org/10.5353/th_b5312328 ; http://hdl.handle.net/10722/219899

Chicago Manual of Style (16^th Edition):

Zhang, Xinchen. “Controlling nonenzymatic browning reactions by selected dietary polyphenols in chemical and food models.” 2014. Doctoral Dissertation, University of Hong Kong. Accessed February 16, 2020. Zhang, X. [张忻晨]. (2014). Controlling nonenzymatic browning reactions by selected dietary polyphenols in chemical and food models. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5312328 ; http://dx.doi.org/10.5353/th_b5312328 ; http://hdl.handle.net/10722/219899.

MLA Handbook (7^th Edition):

Zhang, Xinchen. “Controlling nonenzymatic browning reactions by selected dietary polyphenols in chemical and food models.” 2014. Web. 16 Feb 2020.

Vancouver:

Zhang X. Controlling nonenzymatic browning reactions by selected dietary polyphenols in chemical and food models. [Internet] [Doctoral dissertation]. University of Hong Kong; 2014. [cited 2020 Feb 16]. Available from: Zhang, X. [张忻晨]. (2014). Controlling nonenzymatic browning reactions by selected dietary polyphenols in chemical and food models. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5312328 ; http://dx.doi.org/10.5353/th_b5312328 ; http://hdl.handle.net/10722/219899.

Council of Science Editors:

Zhang X. Controlling nonenzymatic browning reactions by selected dietary polyphenols in chemical and food models. [Doctoral Dissertation]. University of Hong Kong; 2014. Available from: Zhang, X. [张忻晨]. (2014). Controlling nonenzymatic browning reactions by selected dietary polyphenols in chemical and food models. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5312328 ; http://dx.doi.org/10.5353/th_b5312328 ; http://hdl.handle.net/10722/219899

University of Guelph

9. Rahimi Yazdi, Saeed. Changing the Structure of Casein Micelles to Improve the Delivery of Bioactive Compounds .

Degree: 2012, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3675

► This thesis is an investigation of binding of casein micelles to polyphenols such as epigallocatechin gallate (EGCG), resveratrol, and curcumin. The incorporation of the bioactive… (more)

▼ This thesis is an investigation of binding of casein micelles to polyphenols such as epigallocatechin gallate (EGCG), resveratrol, and curcumin. The incorporation of the bioactive molecules in casein micelles seems to be beneficial. The results from this study clearly demonstrated that casein micelles can incorporate polyphenols. There is a difference in the binding behaviour between curcumin and resveratrol. Curcumin is able to penetrate the core of the micelles, but resveratrol has less affinity for the hydrophobic sites, instead, it can be bind in the core of the micelles through the water channels. The processing of milk (heating, cooling, static high pressure and microfluidization) alters the surface or the internal structure of the casein micelles resulting in increased incorporation. The release of β-casein caused alteration to the core of the casein micelles, without any effect on the colloidal calcium phosphate composition and any changes in the surface properties of the micelles. These internal rearrangements lead to an increase in the affinity of the hydrophobic sites for curcumin and resveratrol in the inner core of the micelles. This work clearly confirmed that β -casein plays a role in stabilizing internal structures in the casein micelle and its release causes an increase in the micellar size by increasing the hydration and repulsion occurring within the water pockets present in the inhomogeneous inner structure of the casein micelles. Inner core of casein micelles undergoes rearrangements during application of static high pressure and microfluidization. In the case of static high pressure, the results indicated that the persistent rearrangement of the amino acid residues induced by high-pressure treatment result in an increase in the amount of curcumin association with milk proteins. It was shown that in both untreated and microfluidized milk, the presence of polyphenol molecules significantly affects rennet induced gelation, by delaying the gelation. However, the behavior of casein micelles incorporated with resveratrol is different comparing to curcumin, as resveratrol strongly affected the surface interactions during rennet-induced gelation. Further research is needed to explain the practical aspect ( functionalities such as acid gelation, emulsification and foaming) of application of casein micelles as natural nanocarrier of bioactive compounds. Advisors/Committee Members: Corredig, Milena (advisor).

Subjects/Keywords: Casein Micelles; Polyphenols

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rahimi Yazdi, S. (2012). Changing the Structure of Casein Micelles to Improve the Delivery of Bioactive Compounds . (Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3675

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rahimi Yazdi, Saeed. “Changing the Structure of Casein Micelles to Improve the Delivery of Bioactive Compounds .” 2012. Thesis, University of Guelph. Accessed February 16, 2020. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3675.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rahimi Yazdi, Saeed. “Changing the Structure of Casein Micelles to Improve the Delivery of Bioactive Compounds .” 2012. Web. 16 Feb 2020.

Vancouver:

Rahimi Yazdi S. Changing the Structure of Casein Micelles to Improve the Delivery of Bioactive Compounds . [Internet] [Thesis]. University of Guelph; 2012. [cited 2020 Feb 16]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3675.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rahimi Yazdi S. Changing the Structure of Casein Micelles to Improve the Delivery of Bioactive Compounds . [Thesis]. University of Guelph; 2012. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3675

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Cape Peninsula University of Technology

10. Piek, Hannelise. Effect of Rooibos preparation on the total polyphenol content and antioxidant capacity of herbal tea and its consumer characteristics .

Degree: 2016, Cape Peninsula University of Technology

URL: http://etd.cput.ac.za/handle/20.500.11838/2476

► Background: The different types and forms of rooibos and the ways in which it is prepared and flavoured for consumption influences its total polyphenol content… (more)

Subjects/Keywords: Herbal teas; Rooibos tea; Antioxidants; Polyphenols; Polyphenols – Physiological effect; Polyphenols – Health aspects

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Piek, H. (2016). Effect of Rooibos preparation on the total polyphenol content and antioxidant capacity of herbal tea and its consumer characteristics . (Thesis). Cape Peninsula University of Technology. Retrieved from http://etd.cput.ac.za/handle/20.500.11838/2476

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Piek, Hannelise. “Effect of Rooibos preparation on the total polyphenol content and antioxidant capacity of herbal tea and its consumer characteristics .” 2016. Thesis, Cape Peninsula University of Technology. Accessed February 16, 2020. http://etd.cput.ac.za/handle/20.500.11838/2476.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Piek, Hannelise. “Effect of Rooibos preparation on the total polyphenol content and antioxidant capacity of herbal tea and its consumer characteristics .” 2016. Web. 16 Feb 2020.

Vancouver:

Piek H. Effect of Rooibos preparation on the total polyphenol content and antioxidant capacity of herbal tea and its consumer characteristics . [Internet] [Thesis]. Cape Peninsula University of Technology; 2016. [cited 2020 Feb 16]. Available from: http://etd.cput.ac.za/handle/20.500.11838/2476.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Piek H. Effect of Rooibos preparation on the total polyphenol content and antioxidant capacity of herbal tea and its consumer characteristics . [Thesis]. Cape Peninsula University of Technology; 2016. Available from: http://etd.cput.ac.za/handle/20.500.11838/2476

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

11. Arbizu Berrocal, Shirley. Anti-inflammatory and Cytotoxic Activities of Mango (Mangifera indica L. var Keitt) Polyphenols in Cancer and Non-cancer Breast Fibroblasts in Vitro.

Degree: 2013, Texas A&M University

URL: http://hdl.handle.net/1969.1/151359

► Breast cancer is the leading cause of cancer death among women worldwide and polyphenols are under investigation as an alternative to conventional treatment approaches of… (more)

▼ Breast cancer is the leading cause of cancer death among women worldwide and polyphenols are under investigation as an alternative to conventional treatment approaches of breast cancer. The anti-inflammatory and anti-proliferative activities of polyphenols have been demonstrated in many studies, yet cellular targets and the underlying cellular mechanisms remain unclear. The overall goal of this study was to investigate the anti-inflammatory and cytotoxic properties of polyphenol compounds extracted from the mango variety Keitt in MCF-12A breast non-cancer and MDA-MB231 breast cancer cells by assessing the modulation of signaling pathways involved in inflammation and carcinogenesis. Mango polyphenols were identified by HPLC-MS analysis. The generation of reactive oxygen species was performed using fluorescence intensity in the DCFH-DA assay. Gene expression was analyzed by qRT-PCR, and protein expression was conducted by Western Blotting and Multiplex Bead assay analysis. Bioactive compounds identified in the mango pulp by HPLC-MS included a great variety of polyphenols such as gallic acid, galloyl glucosides with different degree of polymerization and other polyphenols. The anti-inflammatory activities of mango polyphenols were evaluated in MCF-12A non cancer breast fibroblasts. An inflammatory microenvironment for MCF-12A breast cells was induced with tumor necrosis factor alpha (TNF-?). The generation of reactive oxygen species was suppressed significantly compared to cells induced with TNF-?, where there was no significant difference between the concentrations of mango polyphenol extract. Results showed a significant down-regulation of mRNA and protein expression of inflammatory genes involved in the PI3K/AKT pathway and related downstream targets such as NF-?B and mTOR involved in biological processes including cell growth, proliferation and survival. Moreover, mango polyphenols had a significant impact on the miRNA-126-PI3K/AKT axis which plays an important role in inflammation and carcinogenesis, suggesting a potential anti-inflammatory underlying mechanism. The cytotoxic effects of mango polyphenols were investigated in MDA-MB231 breast cancer cells. Mango polyphenols decreased the production of reactive oxygen species; however no significant differences were found between the tested concentrations of mango polyphenols. The gene expression of proapoptotic factors involved in the intrinsic mitochondrial pathway such as cytochrome C and caspase-3 were significantly regulated after mango polyphenol treatment. In addition, the suppression of the PI3K/AKT/mTOR pathway and downstream effectors such as HIF-1? and VEGF as well as the disruption of the miRNA-21-PTEN/AKT axis were identified as potential underlying mechanism of the cytotoxic properties of mango polyphenols. Overall, findings from this study show that mango polyphenols counteract inflammatory and cancerous cell signaling processes; therefore the potential of mango polyphenols in the prevention of breast-cancer focusing on the… Advisors/Committee Members: Talcott, Susanne U (advisor), Talcott, Stephen T (committee member), Awika, Joseph M (committee member).

Subjects/Keywords: mango; polyphenols; inflammation; breast cancer

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Arbizu Berrocal, S. (2013). Anti-inflammatory and Cytotoxic Activities of Mango (Mangifera indica L. var Keitt) Polyphenols in Cancer and Non-cancer Breast Fibroblasts in Vitro. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/151359

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Arbizu Berrocal, Shirley. “Anti-inflammatory and Cytotoxic Activities of Mango (Mangifera indica L. var Keitt) Polyphenols in Cancer and Non-cancer Breast Fibroblasts in Vitro.” 2013. Thesis, Texas A&M University. Accessed February 16, 2020. http://hdl.handle.net/1969.1/151359.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Arbizu Berrocal, Shirley. “Anti-inflammatory and Cytotoxic Activities of Mango (Mangifera indica L. var Keitt) Polyphenols in Cancer and Non-cancer Breast Fibroblasts in Vitro.” 2013. Web. 16 Feb 2020.

Vancouver:

Arbizu Berrocal S. Anti-inflammatory and Cytotoxic Activities of Mango (Mangifera indica L. var Keitt) Polyphenols in Cancer and Non-cancer Breast Fibroblasts in Vitro. [Internet] [Thesis]. Texas A&M University; 2013. [cited 2020 Feb 16]. Available from: http://hdl.handle.net/1969.1/151359.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arbizu Berrocal S. Anti-inflammatory and Cytotoxic Activities of Mango (Mangifera indica L. var Keitt) Polyphenols in Cancer and Non-cancer Breast Fibroblasts in Vitro. [Thesis]. Texas A&M University; 2013. Available from: http://hdl.handle.net/1969.1/151359

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Oregon State University

12. McLaughlin, Ian R. Bitterness modifying properties of hop polyphenols.

Degree: MS, Food Science and Technology, 2005, Oregon State University

URL: http://hdl.handle.net/1957/27328

Subjects/Keywords: Plant polyphenols

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McLaughlin, I. R. (2005). Bitterness modifying properties of hop polyphenols. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/27328

Chicago Manual of Style (16^th Edition):

McLaughlin, Ian R. “Bitterness modifying properties of hop polyphenols.” 2005. Masters Thesis, Oregon State University. Accessed February 16, 2020. http://hdl.handle.net/1957/27328.

MLA Handbook (7^th Edition):

McLaughlin, Ian R. “Bitterness modifying properties of hop polyphenols.” 2005. Web. 16 Feb 2020.

Vancouver:

McLaughlin IR. Bitterness modifying properties of hop polyphenols. [Internet] [Masters thesis]. Oregon State University; 2005. [cited 2020 Feb 16]. Available from: http://hdl.handle.net/1957/27328.

Council of Science Editors:

McLaughlin IR. Bitterness modifying properties of hop polyphenols. [Masters Thesis]. Oregon State University; 2005. Available from: http://hdl.handle.net/1957/27328

University of Hong Kong

13. Ling, Ka-ho. Polyphenol-mediated protective effects against bacterial translocation across intestinal epithelial cells and their mechanisms.

Degree: PhD, 2015, University of Hong Kong

URL: Ling, K. [凌加豪]. (2015). Polyphenol-mediated protective effects against bacterial translocation across intestinal epithelial cells and their mechanisms. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5699899. ; http://dx.doi.org/10.5353/th_b5699899 ; http://hdl.handle.net/10722/236746

► An intact intestinal barrier maintains gut health by keeping pathogens at bay. Normally, the intestinal barrier is very effective —the luminal side is heavily infested… (more)

▼ An intact intestinal barrier maintains gut health by keeping pathogens at bay. Normally, the intestinal barrier is very effective —the luminal side is heavily infested with more than 1012microbes per milliliter of fecal materials, yet the basolateral side (portal blood and mesenteric lymph nodes) is virtually sterile. However, insults from the external environment, such as food toxins, drugs and pathogens, can undermine intestinal integrity. A compromised intestinal barrier (leaky gut) is prone to bacterial translocation, predisposing one to various gastrointestinal disorders. Polyphenols (PPs) are widely present in plant-based foods and beverages, with daily human consumption estimated at up to several hundred milligrams. Therefore, intestinal epithelial cells (IECs) are constantly and directly exposed to a high dose of PPs. However, the effect of PPs on the intestinal barrier remains largely unexplored. The present study aimed to identify dietary PPs that can improve gut health by reducing bacterial translocation across IEC monolayers. Principal action mechanism(s) were characterized. Cell-based in vitroassays were performed using polarized porcine IECs, IPEC-J2, cultured on permeable membrane supports. Translocation of Escherichia coliacross the cell monolayers was first determined by agar plate counting. Further mechanistic analyses —applying electrophysiology assay, unidirectional tracer flux assay, antibacterial assay, quantitative reverse transcriptase polymerase chain reaction, protein immunoblotting, enzyme-linked immunosorbent assay, and Luminex multiplex assay —were then undertaken to characterize PP-mediated protective effects in normal and deoxynivalenol (DON)-damaged cell monolayers. Selected dietary PPs, including chlorogenic acid, epigallocatechin gallate (EGCG), quercetin, resveratrol (RES) and rutin, were screened. It was revealed that EGCG and RES, present in green tea and red wine respectively, significantly reduced E. colitranslocation. In further mechanistic investigation, the two PPs were shown to function differently: RES enhanced the physical barrier (strengthening tight junctions), while EGCG enhanced the immunological barrier (inducing antimicrobial peptides secretion). In detail, RES promoted the assembly of claudin-4 to the tight junction complex in normal cells, and protected against DON-induced barrier dysfunction by preventing dissociation of claudin-4 from actin cytoskeleton, through modulation of IL-6 and IL-8 secretion in a mitogen activated protein kinase (MAPK)-dependent response. Meanwhile, EGCG reduced bacterial translocation, in normal and DON-damaged cells, by stimulating the release of cytoplasmic β-defensin-1 via a MAPK-independent pathway, as well as upregulating gene expression and production ofβ-defensin-2 via a p38 MAPK signaling pathway. The present study reveals, for the first time, that PPs can reduce bacterial translocation across IECs. Our findings have highlighted a great potential of dietary intervention with PPs to uphold intestinal…

Subjects/Keywords: Epithelial cells; Polyphenols; Intestines - Microbiology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ling, K. (2015). Polyphenol-mediated protective effects against bacterial translocation across intestinal epithelial cells and their mechanisms. (Doctoral Dissertation). University of Hong Kong. Retrieved from Ling, K. [凌加豪]. (2015). Polyphenol-mediated protective effects against bacterial translocation across intestinal epithelial cells and their mechanisms. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5699899. ; http://dx.doi.org/10.5353/th_b5699899 ; http://hdl.handle.net/10722/236746

Chicago Manual of Style (16^th Edition):

Ling, Ka-ho. “Polyphenol-mediated protective effects against bacterial translocation across intestinal epithelial cells and their mechanisms.” 2015. Doctoral Dissertation, University of Hong Kong. Accessed February 16, 2020. Ling, K. [凌加豪]. (2015). Polyphenol-mediated protective effects against bacterial translocation across intestinal epithelial cells and their mechanisms. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5699899. ; http://dx.doi.org/10.5353/th_b5699899 ; http://hdl.handle.net/10722/236746.

MLA Handbook (7^th Edition):

Ling, Ka-ho. “Polyphenol-mediated protective effects against bacterial translocation across intestinal epithelial cells and their mechanisms.” 2015. Web. 16 Feb 2020.

Vancouver:

Ling K. Polyphenol-mediated protective effects against bacterial translocation across intestinal epithelial cells and their mechanisms. [Internet] [Doctoral dissertation]. University of Hong Kong; 2015. [cited 2020 Feb 16]. Available from: Ling, K. [凌加豪]. (2015). Polyphenol-mediated protective effects against bacterial translocation across intestinal epithelial cells and their mechanisms. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5699899. ; http://dx.doi.org/10.5353/th_b5699899 ; http://hdl.handle.net/10722/236746.

Council of Science Editors:

Ling K. Polyphenol-mediated protective effects against bacterial translocation across intestinal epithelial cells and their mechanisms. [Doctoral Dissertation]. University of Hong Kong; 2015. Available from: Ling, K. [凌加豪]. (2015). Polyphenol-mediated protective effects against bacterial translocation across intestinal epithelial cells and their mechanisms. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5699899. ; http://dx.doi.org/10.5353/th_b5699899 ; http://hdl.handle.net/10722/236746

University of Hong Kong

14. Gan, Renyou. Compositional and functional study of antioxidant polyphenols in edible beans and their related products.

Degree: PhD, 2015, University of Hong Kong

URL: Gan, R. [甘人友]. (2015). Compositional and functional study of antioxidant polyphenols in edible beans and their related products. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5736659. ; http://dx.doi.org/10.5353/th_b5736659 ; http://hdl.handle.net/10722/238970

► Edible beans are natural sources of antioxidant polyphenols, but their polyphenol composition and bioactivities have been little investigated compared to many fruits and vegetables. In… (more)

▼ Edible beans are natural sources of antioxidant polyphenols, but their polyphenol composition and bioactivities have been little investigated compared to many fruits and vegetables. In this study, phenolic composition and bioactivities, mainly antioxidant capacity, were systematically investigated in edible beans and their related products. A large scale screening was performed to investigate antioxidant capacity and total phenolic content in 42 edible bean genotypes. Edible beans had a wide range of antioxidant polyphenols and their bound phenolics were generally higher than in common fruits and vegetables. The red sword bean (Canavalia gladiata) was found to have the highest level of antioxidant polyphenols among the genotypes tested. Further study showed that the sword bean coat was rich in antioxidant polyphenols, mainly gallic acid and its derivatives. In addition, pigmented edible beans had higher levels of antioxidant polyphenols than non-pigmented ones due to their pigmented bean coats, which were rich in proanthocyanidins and flavonoids, and exhibited antioxidant and antibacterial effects. Next, antioxidant polyphenols were investigated in edible bean sprouts. Germination was found to cause accumulation of antioxidant polyphenols in 12 edible bean sprouts, and the mung bean (Vigna radiata) sprout had the highest level of antioxidant polyphenols among them. Further study found that antioxidant polyphenols in green and black mung bean sprouts increased in a time-dependent manner during a 5-day germination period, accompanied with agradual increase of several phenolic compounds, such as caffeic acid, gallic acid, p-coumaric acid and rutin. Subsequently, the influences of thermal treatments on antioxidant polyphenols of bean products were investigated. Hot air drying at 70 and 80 °C for 24 hr was found to notably increase antioxidant polyphenols in mung bean sprouts, simultaneously with evident browning and increased content of caffeic acid. On the other hand, steaming was better than boiling to increase antioxidant polyphenols in five edible bean milks. In particular, steaming substantially increased isoflavone glucosides but slightly reduced isoflavone aglycones in soybean milk. Overall, thermal treatments could induce interconversion between soluble polyphenols, and release of bound polyphenols and the products of Maillard reaction, all of which could contribute to increased antioxidant polyphenol contentin tested bean products. Finally, the effects of fermentation on antioxidant polyphenols in edible legumes and bean milks were investigated. Fermentation had varying effects on their antioxidant capacity, while in general increasingtheir total phenolic content. Fermented mottled cowpea had the highest antioxidant polyphenol levelamong eight fermented edible legumes, with substantially increased catechin content. Additionally, the lipophilic fraction had much higher free radical scavenging capacity than the commonly investigated hydrophilic fraction in fermented and non-fermented mung bean and…

Subjects/Keywords: Beans; Plant polyphenols; Antioxidants

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gan, R. (2015). Compositional and functional study of antioxidant polyphenols in edible beans and their related products. (Doctoral Dissertation). University of Hong Kong. Retrieved from Gan, R. [甘人友]. (2015). Compositional and functional study of antioxidant polyphenols in edible beans and their related products. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5736659. ; http://dx.doi.org/10.5353/th_b5736659 ; http://hdl.handle.net/10722/238970

Chicago Manual of Style (16^th Edition):

Gan, Renyou. “Compositional and functional study of antioxidant polyphenols in edible beans and their related products.” 2015. Doctoral Dissertation, University of Hong Kong. Accessed February 16, 2020. Gan, R. [甘人友]. (2015). Compositional and functional study of antioxidant polyphenols in edible beans and their related products. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5736659. ; http://dx.doi.org/10.5353/th_b5736659 ; http://hdl.handle.net/10722/238970.

MLA Handbook (7^th Edition):

Gan, Renyou. “Compositional and functional study of antioxidant polyphenols in edible beans and their related products.” 2015. Web. 16 Feb 2020.

Vancouver:

Gan R. Compositional and functional study of antioxidant polyphenols in edible beans and their related products. [Internet] [Doctoral dissertation]. University of Hong Kong; 2015. [cited 2020 Feb 16]. Available from: Gan, R. [甘人友]. (2015). Compositional and functional study of antioxidant polyphenols in edible beans and their related products. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5736659. ; http://dx.doi.org/10.5353/th_b5736659 ; http://hdl.handle.net/10722/238970.

Council of Science Editors:

Gan R. Compositional and functional study of antioxidant polyphenols in edible beans and their related products. [Doctoral Dissertation]. University of Hong Kong; 2015. Available from: Gan, R. [甘人友]. (2015). Compositional and functional study of antioxidant polyphenols in edible beans and their related products. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5736659. ; http://dx.doi.org/10.5353/th_b5736659 ; http://hdl.handle.net/10722/238970

University of Hong Kong

15. 朱芹; Zhu, Qin. Protective effects of natural polyphenols in reactive carbonylspecies/lipid peroxidation-induced toxicity.

Degree: PhD, 2011, University of Hong Kong

URL: Zhu, Q. [朱芹]. (2011). Protective effects of natural polyphenols in reactive carbonyl species/lipid peroxidation-induced toxicity. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4715553 ; http://dx.doi.org/10.5353/th_b4715553 ; http://hdl.handle.net/10722/180004

► Oxidative degradation of lipids, not only leads to the quality deterioration in foodstuffs but also associates with a multitude of physiological processes. One of the… (more)

▼ Oxidative degradation of lipids, not only leads to the quality deterioration in foodstuffs but also associates with a multitude of physiological processes. One of the causations involved in these damaging effects is the generation of reactive carbonyl species (RCS) in lipid peroxidation process. RCS are notorious toxins that possess reactivity towards biological nucleophiles (such as proteins and DNA) with potential functional alternation in these biomolecules. Therefore, the exogenous intervention is required to inhibit the toxicity related to RCS/lipid peroxidation. In present study, the screening for effective natural polyphenols to trap two representative RCS, acrolein (ACR) and 4-hydroxy-trans-2-nonenal (HNE), was performed with mechanism elucidation. It was found that the polyphenols from the categories of flavan-3-ols, theaflavins, cyanomaclurins and dihydrochalcones were effective scavengers of ACR/HNE. Subsequently, facilitated by HPLC, LC-MS/MS and NMR analysis, the characterization of polyphenols’ as sacrificial nucleophiles towards these two electrophiles products was accomplished. Michael addition at A ring of polyphenols’ to the C=C bond of ACR/HNE was suggested to be responsible for trapping of these two RCS and thus render their active sites unavailable to covalently modify critical biomolecules. Further investigation of phloretin’s effect to attenuate ACR-induced modification on lysine residue and proteins was carried out. Phloretin’s protective effect against ACR’s toxicity was clearly reflected by its inhibition of the formation of Nε-(3-formyl-3,4-dehydropiperidino) lysine (FDP-lysine), blocking the electrophilic site in FDP-lysine, lowering protein carbonylation in bovine serum albumin (BSA) and lessening protein oligomerization in bovine pancreas ribonuclease A. Such protection might be mediated by phloretin’s directly trapping of ACR and consequently deactivation of ACR in covalent modification of amino acids and proteins. The biological relevance of polyphenols’ trapping activity of ACR was explored in a cell culture model. Natural polyphenols including phloretin, EGCG and quercetin were proved to be active to inhibit ACR-induced cytotoxicity in human neuroblastoma SH-SY5Y cells. The cytoprotection of phloretin (as the most potent one in alleviation of ACR stress) was suggested to be achieved through the reduction of the increased cellular protein carbonyl level as revealed by Western blotting analysis. In the final part of this study, an in vitro system containing metal-catalyzed fatty acids and BSA was established to study the modification on protein induced by lipid peroxidation and possible inhibitory effects conferred by some natural polyphenols. The protective effects of these polyphenols against lipid peroxidation-induced modification on BSA was manifested by the observation of reduced levels of high-molecular-weight proteins, MDA-related fluorescent substances and protein carbonylation. However, poor correlations were found between such protection and antioxidant activities,…

Subjects/Keywords: Polyphenols.; Lipids - Peroxidation.; Carbonyl compounds.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

朱芹; Zhu, Q. (2011). Protective effects of natural polyphenols in reactive carbonylspecies/lipid peroxidation-induced toxicity. (Doctoral Dissertation). University of Hong Kong. Retrieved from Zhu, Q. [朱芹]. (2011). Protective effects of natural polyphenols in reactive carbonyl species/lipid peroxidation-induced toxicity. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4715553 ; http://dx.doi.org/10.5353/th_b4715553 ; http://hdl.handle.net/10722/180004

Chicago Manual of Style (16^th Edition):

朱芹; Zhu, Qin. “Protective effects of natural polyphenols in reactive carbonylspecies/lipid peroxidation-induced toxicity.” 2011. Doctoral Dissertation, University of Hong Kong. Accessed February 16, 2020. Zhu, Q. [朱芹]. (2011). Protective effects of natural polyphenols in reactive carbonyl species/lipid peroxidation-induced toxicity. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4715553 ; http://dx.doi.org/10.5353/th_b4715553 ; http://hdl.handle.net/10722/180004.

MLA Handbook (7^th Edition):

朱芹; Zhu, Qin. “Protective effects of natural polyphenols in reactive carbonylspecies/lipid peroxidation-induced toxicity.” 2011. Web. 16 Feb 2020.

Vancouver:

朱芹; Zhu Q. Protective effects of natural polyphenols in reactive carbonylspecies/lipid peroxidation-induced toxicity. [Internet] [Doctoral dissertation]. University of Hong Kong; 2011. [cited 2020 Feb 16]. Available from: Zhu, Q. [朱芹]. (2011). Protective effects of natural polyphenols in reactive carbonyl species/lipid peroxidation-induced toxicity. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4715553 ; http://dx.doi.org/10.5353/th_b4715553 ; http://hdl.handle.net/10722/180004.

Council of Science Editors:

朱芹; Zhu Q. Protective effects of natural polyphenols in reactive carbonylspecies/lipid peroxidation-induced toxicity. [Doctoral Dissertation]. University of Hong Kong; 2011. Available from: Zhu, Q. [朱芹]. (2011). Protective effects of natural polyphenols in reactive carbonyl species/lipid peroxidation-induced toxicity. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4715553 ; http://dx.doi.org/10.5353/th_b4715553 ; http://hdl.handle.net/10722/180004

Université Catholique de Louvain

16. Winand, Julie. In vitro interactions of adipocytes and macrophages : potential roles of vegetal extracts in obesity prevention.

Degree: 2013, Université Catholique de Louvain

URL: http://hdl.handle.net/2078.1/136115

► Obesity and overweight are a plague that concerns more than 20 % of the world population. People suffering from these states present excessive fat accumulation… (more)

▼ Obesity and overweight are a plague that concerns more than 20 % of the world population. People suffering from these states present excessive fat accumulation that could impair health. The main causes are an increased intake of energy-dense food and an increased physical inactivity. The energy excess is stored in the adipose tissue whose functions are deregulated, which induces obesity linked metabolic complications. Indeed, most of the time, obesity is accompanied by metabolic disorders, i.e. type 2 diabetes, cardiovascular disease… Medical interventions are possible but they often appear ineffective, this is why preventive actions need to be set up. This study aimed at investigating the potential beneficial effects of fruit derivatives (i.e., pomegranate husk extract and three apple extracts) on the development of obesity and its metabolic disorders by focusing on the adipose tissue functions. In case of weight gain, the adipose tissues, responsible for the energy storage, have to increase their storage capacity by increasing the size of the adipocytes as well as their number by inducing the differentiation of preadipocytes (adipogenesis). This leads to an increasing body fat mass associated with the obesity complications. In order to identify potential natural candidates that could reduce the adipose tissue expansion linked to obesity development, we have studied the effect of a pomegranate husk extract and three apple extracts on adipogenesis and fat accumulation in vitro. Thanks to fluorescence microscopy technics, we have shown that the pomegranate husk and apple extracts could partially inhibit the adipogenesis and the lipid accumulation. These first results make of these extracts interesting candidates for additional investigations. The second part of this work was focused on the adipose tissue inflammation. Indeed, the adipose tissue of obese people is characterized by a chronic low grade inflammation that could spread throughout the body and induce metabolic disorders. This inflammation is mainly due to an interaction between hypertrophied adipocytes and inflamed macrophages found in the adipose tissues. This condition has been simulated in vitro in order to investigate the potential anti-inflammatory effect of the extracts of interest (i.e., the pomegranate husk extract and three apple extracts). The expression and secretion of pro-inflammatory markers were followed, i.e. IL-6, TNF and CCL-2 as well as the anti-inflammatory adipokine, i.e. adiponectin. Although the pomegranate husk extract was able to reduce the inflammatory secretions of adipocytes or macrophages cultivated independently, the extract was no more able to decrease the inflammation maintained by the both cell types cultivated together. Nevertheless, the three apple extracts have revealed interesting anti-inflammatory effects on the cells monocultivated and cocultivated by reducing the secretion, as well as the expression, of pro-inflammatory mediators. Taken as a whole, the results reported in this work allow to highlighte that natural… Advisors/Committee Members: UCL - SST/ISV - Institut des sciences de la vie, UCL - Faculté des Sciences, Gerin, Isabelle, Francaux, Marc, Bohn, Torsten, Schneider, Yves-Jacques, Van Den Bosch, Philippe, Debier, Cathy.

Subjects/Keywords: obesity; polyphenols; inflammation; lipid accumulation

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Winand, J. (2013). In vitro interactions of adipocytes and macrophages : potential roles of vegetal extracts in obesity prevention. (Thesis). Université Catholique de Louvain. Retrieved from http://hdl.handle.net/2078.1/136115

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Winand, Julie. “In vitro interactions of adipocytes and macrophages : potential roles of vegetal extracts in obesity prevention.” 2013. Thesis, Université Catholique de Louvain. Accessed February 16, 2020. http://hdl.handle.net/2078.1/136115.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Winand, Julie. “In vitro interactions of adipocytes and macrophages : potential roles of vegetal extracts in obesity prevention.” 2013. Web. 16 Feb 2020.

Vancouver:

Winand J. In vitro interactions of adipocytes and macrophages : potential roles of vegetal extracts in obesity prevention. [Internet] [Thesis]. Université Catholique de Louvain; 2013. [cited 2020 Feb 16]. Available from: http://hdl.handle.net/2078.1/136115.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Winand J. In vitro interactions of adipocytes and macrophages : potential roles of vegetal extracts in obesity prevention. [Thesis]. Université Catholique de Louvain; 2013. Available from: http://hdl.handle.net/2078.1/136115

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Aberdeen

17. Deakin, Sherine Jane. Antioxidant effects of phytochemicals in conditions of oxidative stress : impact on endothelial cell survival and function.

Degree: 2010, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=165549 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540542

► Two dietary polyphenols, delphinidin and resveratrol, were selected for this study; delphinidin, an anthocyanin flavonoid, was found to elicit cardioprotective properties from a pilot study… (more)

Subjects/Keywords: 615.1; Antioxidants : Polyphenols : Phenols : Phytochemicals

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Deakin, S. J. (2010). Antioxidant effects of phytochemicals in conditions of oxidative stress : impact on endothelial cell survival and function. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=165549 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540542

Chicago Manual of Style (16^th Edition):

Deakin, Sherine Jane. “Antioxidant effects of phytochemicals in conditions of oxidative stress : impact on endothelial cell survival and function.” 2010. Doctoral Dissertation, University of Aberdeen. Accessed February 16, 2020. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=165549 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540542.

MLA Handbook (7^th Edition):

Deakin, Sherine Jane. “Antioxidant effects of phytochemicals in conditions of oxidative stress : impact on endothelial cell survival and function.” 2010. Web. 16 Feb 2020.

Vancouver:

Deakin SJ. Antioxidant effects of phytochemicals in conditions of oxidative stress : impact on endothelial cell survival and function. [Internet] [Doctoral dissertation]. University of Aberdeen; 2010. [cited 2020 Feb 16]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=165549 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540542.

Council of Science Editors:

Deakin SJ. Antioxidant effects of phytochemicals in conditions of oxidative stress : impact on endothelial cell survival and function. [Doctoral Dissertation]. University of Aberdeen; 2010. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=165549 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540542

18. Yaoraporn Sangsen. Development and evaluation of lipid-based oral delivery systems for oxyresveratrol .

Degree: คณะเภสัชศาสตร์ ภาควิชาเทคโนโลยีเภสัชกรรม, 2016, Prince of Songkla University

URL: http://kb.psu.ac.th/psukb/handle/2016/11122

Subjects/Keywords: Oxyresveratrol; Polyphenols

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sangsen, Y. (2016). Development and evaluation of lipid-based oral delivery systems for oxyresveratrol . (Thesis). Prince of Songkla University. Retrieved from http://kb.psu.ac.th/psukb/handle/2016/11122

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sangsen, Yaoraporn. “Development and evaluation of lipid-based oral delivery systems for oxyresveratrol .” 2016. Thesis, Prince of Songkla University. Accessed February 16, 2020. http://kb.psu.ac.th/psukb/handle/2016/11122.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sangsen, Yaoraporn. “Development and evaluation of lipid-based oral delivery systems for oxyresveratrol .” 2016. Web. 16 Feb 2020.

Vancouver:

Sangsen Y. Development and evaluation of lipid-based oral delivery systems for oxyresveratrol . [Internet] [Thesis]. Prince of Songkla University; 2016. [cited 2020 Feb 16]. Available from: http://kb.psu.ac.th/psukb/handle/2016/11122.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sangsen Y. Development and evaluation of lipid-based oral delivery systems for oxyresveratrol . [Thesis]. Prince of Songkla University; 2016. Available from: http://kb.psu.ac.th/psukb/handle/2016/11122

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

East Tennessee State University

19. Ressler, Daniel. Synthesis of Resveratrol Ester Derivatives.

Degree: MS, Chemistry, 2013, East Tennessee State University

URL: https://dc.etsu.edu/etd/1234

► The goal of this research project was to synthesize derivatives of transresveratrol. In order for resveratrol to be activated and used by the body… (more)

Subjects/Keywords: Polyphenols; Stilbenoid; Resveratrol; Phytoalexin; Chemistry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ressler, D. (2013). Synthesis of Resveratrol Ester Derivatives. (Masters Thesis). East Tennessee State University. Retrieved from https://dc.etsu.edu/etd/1234

Chicago Manual of Style (16^th Edition):

Ressler, Daniel. “Synthesis of Resveratrol Ester Derivatives.” 2013. Masters Thesis, East Tennessee State University. Accessed February 16, 2020. https://dc.etsu.edu/etd/1234.

MLA Handbook (7^th Edition):

Ressler, Daniel. “Synthesis of Resveratrol Ester Derivatives.” 2013. Web. 16 Feb 2020.

Vancouver:

Ressler D. Synthesis of Resveratrol Ester Derivatives. [Internet] [Masters thesis]. East Tennessee State University; 2013. [cited 2020 Feb 16]. Available from: https://dc.etsu.edu/etd/1234.

Council of Science Editors:

Ressler D. Synthesis of Resveratrol Ester Derivatives. [Masters Thesis]. East Tennessee State University; 2013. Available from: https://dc.etsu.edu/etd/1234

20. Bennett, Tyler Paul. The Synthesis and Characterization of Iron Nanoparticles.

Degree: MS, 2015, University of New Hampshire

URL: https://scholars.unh.edu/thesis/1056

► Nanoparticle synthesis has garnered attention for technological applications for catalysts, industrial processing, and medical applications. The size ranges for these is in the particles nanostructural… (more)

▼ Nanoparticle synthesis has garnered attention for technological applications for catalysts, industrial processing, and medical applications. The size ranges for these is in the particles nanostructural domain. Pure iron nanoparticles have been of particular interest for their reactivity and relative biological inertness. Applications include cancer treatment and carrying medicine to a relevant site. Unfortunately, because of their reactivity, pure iron nanoparticles have been difficult to study. This is because of their accelerated tendency to form oxides in air, due to the increased surface area to volume ratio. Using synthesis processes with polyphenols or long chain amines, air stable iron nanoparticles have been produced with a diameter size range of ~ 2 to about ~10 nm, but apparently have transformed due to internal pressure and crystallographic defects to the FCC phase. The FCC crystals have been seen to form icosahedral and decahedral shapes. This size is within the range for use as a catalyst for the growth of both carbon nanotubes and boron nitride nanotubes as well for biomedical applications. The advantages of these kinds of catalysts are that nanotube growth can be for the first time separated from the catalyst formation. Additionally, the catalyst size can be preselected for a certain size nanotube to grow. In summary: (1) we found the size distributions of nanoparticles for various synthesis processes, (2) we discovered the right size range for growth of nanotubes from the iron nanoparticles, (3) the nanoparticles are under a very high internal pressure, (4) the nanoparticles are in the FCC phase, (5) they appear to be in icosahedral and decahedral structures, (6) they undergo room temperature twinning, (7) the FCC crystals are distorted due to carbon in octahedral sites, (8) the iron nanoparticles are stable in air, (9) adding small amounts of copper make the iron nanoparticles smaller. Advisors/Committee Members: David Lashmore, Olof Echt, James Krzanowski.

Subjects/Keywords: Iron; Nanoparticles; Nanotubes; Polyphenols; Physics

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bennett, T. P. (2015). The Synthesis and Characterization of Iron Nanoparticles. (Thesis). University of New Hampshire. Retrieved from https://scholars.unh.edu/thesis/1056

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bennett, Tyler Paul. “The Synthesis and Characterization of Iron Nanoparticles.” 2015. Thesis, University of New Hampshire. Accessed February 16, 2020. https://scholars.unh.edu/thesis/1056.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bennett, Tyler Paul. “The Synthesis and Characterization of Iron Nanoparticles.” 2015. Web. 16 Feb 2020.

Vancouver:

Bennett TP. The Synthesis and Characterization of Iron Nanoparticles. [Internet] [Thesis]. University of New Hampshire; 2015. [cited 2020 Feb 16]. Available from: https://scholars.unh.edu/thesis/1056.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bennett TP. The Synthesis and Characterization of Iron Nanoparticles. [Thesis]. University of New Hampshire; 2015. Available from: https://scholars.unh.edu/thesis/1056

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New South Wales

21. Swift, Joseph. Identification of small molecule inhibitors of protein aggregation.

Degree: Biotechnology & Biomolecular Sciences, 2013, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/52779 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11452/SOURCE01?view=true

► Therapeutic antibodies utilize the adaptive immune response to treat complex disease states. Antibodies’ success in therapeutic applications has led to their domination of total biologics… (more)

▼ Therapeutic antibodies utilize the adaptive immune response to treat complex disease states. Antibodies’ success in therapeutic applications has led to their domination of total biologics revenue. With more therapeutic antibodies currently in development, as well as many new drug targets being discovered, there is little doubt that this sector will continue to grow. However, bottlenecks exist in therapeutic antibody development. One constraint in antibody development is antibody aggregation. Formulating antibodies can be problematic, as in vitro preparations require high protein concentrations that can promote aggregation. Each antibody peptide sequence is unique within complimentary determining regions (CDRs); this region provides antibody specificity to an antigen target. However the CDR region can also determine the aggregation properties of the molecule. The resulting difference in aggregation properties between antibodies prevents development of a general approach to inhibit aggregation occurring in vitro. Antibody aggregation can also cause disease. Light Chain Deposition Disease (LCDD) is a condition caused by aggregation of light chain antibodies in vivo. It often results in amyloid deposits affecting vital organ function. The primary aim of this thesis was to discover a chemical compound that could inhibit in vitro antibody aggregation. A tertiary aim was to establish that a candidate compound could also serve as a potential drug candidate in LCDD treatment. To achieve this, CDR mediated aggregation was modeled with variable light chain domain antibodies (VLs) displayed on phage and in soluble form. A method utilizing phage-display was developed to detect FDA approved compounds that could inhibit CDR mediated VL aggregation. Specifically, The Prestwick Chemical Library of 1200 compounds was screened with phage expressing aggregation prone VL DPK9 using a ‘heat-cool’ ELISA method. This screen identified Levodopa and Apomorphine as compounds that could prevent aggregation of DPK9. Further testing demonstrated that Levodopa and Apomorphine could also successfully prevent aggregation of soluble VL proteins. Structural analysis demonstrated that the catechol moiety present on both Levodopa and Apomorphine prevented aggregation of VL protein. This led to the discovery of four other polyphenol compounds also capable of preventing VL aggregation. Further experimentation also allowed for the mechanism of action of the catechol moiety to be partially understood. All candidate compounds identified were either FDA approved or naturally occurring polyphenols. Consequently such compounds may have direct implications as excipients in antibody in vitro formulation and as drug candidates for treatment of LCDD. Advisors/Committee Members: Christ, Daniel , Clinical School - St Vincent's Hospital, Faculty of Medicine, UNSW.

Subjects/Keywords: Aggregation; Domain antibodies; Polyphenols

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Swift, J. (2013). Identification of small molecule inhibitors of protein aggregation. (Masters Thesis). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/52779 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11452/SOURCE01?view=true

Chicago Manual of Style (16^th Edition):

Swift, Joseph. “Identification of small molecule inhibitors of protein aggregation.” 2013. Masters Thesis, University of New South Wales. Accessed February 16, 2020. http://handle.unsw.edu.au/1959.4/52779 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11452/SOURCE01?view=true.

MLA Handbook (7^th Edition):

Swift, Joseph. “Identification of small molecule inhibitors of protein aggregation.” 2013. Web. 16 Feb 2020.

Vancouver:

Swift J. Identification of small molecule inhibitors of protein aggregation. [Internet] [Masters thesis]. University of New South Wales; 2013. [cited 2020 Feb 16]. Available from: http://handle.unsw.edu.au/1959.4/52779 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11452/SOURCE01?view=true.

Council of Science Editors:

Swift J. Identification of small molecule inhibitors of protein aggregation. [Masters Thesis]. University of New South Wales; 2013. Available from: http://handle.unsw.edu.au/1959.4/52779 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11452/SOURCE01?view=true

University of Guelph

22. YUWEI, QI. Characterization of Phytochemicals and Antioxidant Activities of Specialty Tomatoes .

Degree: 2016, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9663

► Twenty-eight specialty tomato cultivars were studied for the phenolic compositions, antioxidant activities in both hydrophilic and hydrophobic fractions of the samples, and the potential effect… (more)

Subjects/Keywords: FOOD; antioxidant; tomato; polyphenols; carotenoids

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

YUWEI, Q. (2016). Characterization of Phytochemicals and Antioxidant Activities of Specialty Tomatoes . (Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9663

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

YUWEI, QI. “Characterization of Phytochemicals and Antioxidant Activities of Specialty Tomatoes .” 2016. Thesis, University of Guelph. Accessed February 16, 2020. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9663.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

YUWEI, QI. “Characterization of Phytochemicals and Antioxidant Activities of Specialty Tomatoes .” 2016. Web. 16 Feb 2020.

Vancouver:

YUWEI Q. Characterization of Phytochemicals and Antioxidant Activities of Specialty Tomatoes . [Internet] [Thesis]. University of Guelph; 2016. [cited 2020 Feb 16]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9663.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

YUWEI Q. Characterization of Phytochemicals and Antioxidant Activities of Specialty Tomatoes . [Thesis]. University of Guelph; 2016. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9663

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Montana State University

23. Hystad, Steven Michael. The genetic characterization of a nil polyphenol oxidase (PPO) trait for the improvement of end product quality in wheat (Triticum aestivum).

Degree: MS, College of Agriculture, 2014, Montana State University

URL: https://scholarworks.montana.edu/xmlui/handle/1/9359

► Wheat (Triticum aestivum) polyphenol oxidase (PPO) contributes to the time dependent discoloration of Asian noodles. Wheat contains multiple paralogous and orthologous PPO genes expressed in… (more)

▼ Wheat (Triticum aestivum) polyphenol oxidase (PPO) contributes to the time dependent discoloration of Asian noodles. Wheat contains multiple paralogous and orthologous PPO genes expressed in wheat kernels, Ppo-A1, Ppo-D1, Ppo-A2, Ppo-D2, and Ppo-B2. To date, wheat improvement efforts have focused on breeding cultivars containing Ppo-D1 and Ppo-A1 alleles conferring reduced PPO activity. A major impediment to wheat quality improvement is a lack of additional PPO alleles conferring reduced kernel PPO. Thus, the discovery of novel low or null PPO alleles is critical to further reduce PPO and improve noodle color stability. The objective of this study was to 1) Characterize mutations present in a low PPO line 07OR1074 and create molecular markers associated with newly characterized alleles; 2) assess the allelic impact of the newly characterized alleles on kernel PPO activity and upon Chinese white salted noodle quality. To characterize additional mutations present and develop molecular markers, genomic clones were created for each known PPO gene and sequenced. Previously reported very low PPO line, 07OR1074, was found to contain a novel allele at Ppo-A2 and null alleles at Ppo-A1 and Ppo-D1 loci and molecular markers were created that encompassed each mutation. To determine the allelic impact of the new alleles on kernel PPO activity, F3:4 lines were genotyped with the novel molecular markers, grown in the field in Bozeman, Montana, and assayed for kernel PPO activity. Evaluation of lines indicated a substantial genotypic effect on PPO with Ppo-A1 and Ppo-D1 loci contributing significantly (P <.001) to total PPO. To determine the effect of the null PPO alleles upon noodle quality Chinese white salted noodles were produced from both refined white flour and whole wheat flour. The results clearly demonstrate that the null PPO alleles at Ppo-A1 and Ppo-D1 loci produce noodles that are brighter (greater L*), more red (greater a*), and more yellow (greater b*) at 24 and 48 hours. These results show that mutations in Ppo-A1 and Ppo-D1 genes are important to lowering overall wheat kernel PPO activity producing a more desirable and marketable product. Advisors/Committee Members: Chairperson, Graduate Committee: Michael J. Giroux (advisor).

Subjects/Keywords: Wheat.; Polyphenols.; Oxidases.; Noodles.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hystad, S. M. (2014). The genetic characterization of a nil polyphenol oxidase (PPO) trait for the improvement of end product quality in wheat (Triticum aestivum). (Masters Thesis). Montana State University. Retrieved from https://scholarworks.montana.edu/xmlui/handle/1/9359

Chicago Manual of Style (16^th Edition):

Hystad, Steven Michael. “The genetic characterization of a nil polyphenol oxidase (PPO) trait for the improvement of end product quality in wheat (Triticum aestivum).” 2014. Masters Thesis, Montana State University. Accessed February 16, 2020. https://scholarworks.montana.edu/xmlui/handle/1/9359.

MLA Handbook (7^th Edition):

Hystad, Steven Michael. “The genetic characterization of a nil polyphenol oxidase (PPO) trait for the improvement of end product quality in wheat (Triticum aestivum).” 2014. Web. 16 Feb 2020.

Vancouver:

Hystad SM. The genetic characterization of a nil polyphenol oxidase (PPO) trait for the improvement of end product quality in wheat (Triticum aestivum). [Internet] [Masters thesis]. Montana State University; 2014. [cited 2020 Feb 16]. Available from: https://scholarworks.montana.edu/xmlui/handle/1/9359.

Council of Science Editors:

Hystad SM. The genetic characterization of a nil polyphenol oxidase (PPO) trait for the improvement of end product quality in wheat (Triticum aestivum). [Masters Thesis]. Montana State University; 2014. Available from: https://scholarworks.montana.edu/xmlui/handle/1/9359

Dalhousie University

24. Bhullar, Khushwant Singh. Neuroprotective Properties of Partridgeberry (Vaccinium vitis-idaea L. var. minus Lodd) Polyphenols.

Degree: MS, Faculty of Agriculture, 2014, Dalhousie University

URL: http://hdl.handle.net/10222/54008

► This study aimed at the extraction and biochemical characterization of polyphenols of partridgeberry (Vaccinium vitis-idaea L. var. minus Lodd) found in Southern Labrador, Canada and… (more)

Subjects/Keywords: Partridgeberry; Polyphenols; Brain; Alzheimer's Disease; Stroke; Neuroprotection

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bhullar, K. S. (2014). Neuroprotective Properties of Partridgeberry (Vaccinium vitis-idaea L. var. minus Lodd) Polyphenols. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/54008

Chicago Manual of Style (16^th Edition):

Bhullar, Khushwant Singh. “Neuroprotective Properties of Partridgeberry (Vaccinium vitis-idaea L. var. minus Lodd) Polyphenols.” 2014. Masters Thesis, Dalhousie University. Accessed February 16, 2020. http://hdl.handle.net/10222/54008.

MLA Handbook (7^th Edition):

Bhullar, Khushwant Singh. “Neuroprotective Properties of Partridgeberry (Vaccinium vitis-idaea L. var. minus Lodd) Polyphenols.” 2014. Web. 16 Feb 2020.

Vancouver:

Bhullar KS. Neuroprotective Properties of Partridgeberry (Vaccinium vitis-idaea L. var. minus Lodd) Polyphenols. [Internet] [Masters thesis]. Dalhousie University; 2014. [cited 2020 Feb 16]. Available from: http://hdl.handle.net/10222/54008.

Council of Science Editors:

Bhullar KS. Neuroprotective Properties of Partridgeberry (Vaccinium vitis-idaea L. var. minus Lodd) Polyphenols. [Masters Thesis]. Dalhousie University; 2014. Available from: http://hdl.handle.net/10222/54008

Texas A&M University

25. Igwe, Alexandria N. Phytoremediation of Hydrocarbon-Contaminated Soil Using Phenolic-Exuding Horticultural Plants.

Degree: 2015, Texas A&M University

URL: http://hdl.handle.net/1969.1/156145

► A greenhouse experiment was designed to test phenolic-exuding horticultural plant species for their phytoremediation potential in soils contaminated with polycyclic aromatic hydrocarbons (PAHs). Species included… (more)

▼ A greenhouse experiment was designed to test phenolic-exuding horticultural plant species for their phytoremediation potential in soils contaminated with polycyclic aromatic hydrocarbons (PAHs). Species included high-phenolic-exuding plants: Malus sp., Osmanthus fragrans, Sambucus nigra, Castanea pumila, Morus alba, and Myrica cerifera and low-polyphenol-exuding plants: Ziziphus jujube, Ribes aureum, and Cassia fistula. The species were planted in soil amended with benzo[a]pyrene, phenanthrene, and pyrene. After 7 months, nitrogen, phosphorus, and potassium amendments were added each month for three months. Plant roots were harvested; polyphenols were ethanol-extracted and quantified using the Folin-Ciocalteu method. Rhizosphere DNA was extracted, quantified, and the 16S rRNA gene and ITS region were sequenced for bacteria and fungi, respectively. In addition, qPCR was conducted that targeted the 16S rRNA and ITS region of bacteria and fungi, respectively. The highest and lowest concentrations of phenolics were from Sambucus nigra and Ribes aureum, respectively. There were no significant differences between 16S rRNA and ITS abundance among treatments. Sequencing showed a significant difference between the rhizosphere bacterial community compositions on a global level. Specifically, several Actinobacteria were over-represented in the low-phenolic-exuding plants, while high-phenolic-exuding plants were over-represented by several Proteobacteria. There were no significant differences between the fungal populations of treatments and all were dominated by Ascomycota. However, high-phenolic exuders had a higher abundance of Basidiomycota, than the low-phenolic exuders. Results showed that different microbial communities were selected for by high polyphenol-exuding plants and low polyphenol-exuding plants. This selection was more pronounced in bacteria than in fungi. The drastic ways in which bacteria respond to phenolic inputs highlight their importance in phytoremediation. Advisors/Committee Members: Schwab, Arthur P (advisor), Gentry, Terry J (advisor), Karthikeyan, Raghupathy (committee member).

Subjects/Keywords: phytoremediation; bioremediation; phenolic; polyphenols; microbial ecology; MOTHUR

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Igwe, A. N. (2015). Phytoremediation of Hydrocarbon-Contaminated Soil Using Phenolic-Exuding Horticultural Plants. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/156145

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Igwe, Alexandria N. “Phytoremediation of Hydrocarbon-Contaminated Soil Using Phenolic-Exuding Horticultural Plants.” 2015. Thesis, Texas A&M University. Accessed February 16, 2020. http://hdl.handle.net/1969.1/156145.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Igwe, Alexandria N. “Phytoremediation of Hydrocarbon-Contaminated Soil Using Phenolic-Exuding Horticultural Plants.” 2015. Web. 16 Feb 2020.

Vancouver:

Igwe AN. Phytoremediation of Hydrocarbon-Contaminated Soil Using Phenolic-Exuding Horticultural Plants. [Internet] [Thesis]. Texas A&M University; 2015. [cited 2020 Feb 16]. Available from: http://hdl.handle.net/1969.1/156145.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Igwe AN. Phytoremediation of Hydrocarbon-Contaminated Soil Using Phenolic-Exuding Horticultural Plants. [Thesis]. Texas A&M University; 2015. Available from: http://hdl.handle.net/1969.1/156145

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

26. Yang, Liyi. Estrogenic Properties of Sorghum Phenolics: Possible Role in Colon Cancer Prevention.

Degree: 2013, Texas A&M University

URL: http://hdl.handle.net/1969.1/151237

► Consumption of whole grains has been linked to reduced risk of colon cancer. This study determined estrogenic activity of sorghum phenolic extracts of different phenolic… (more)

▼ Consumption of whole grains has been linked to reduced risk of colon cancer. This study determined estrogenic activity of sorghum phenolic extracts of different phenolic profiles and identified possible estrogenic compounds in sorghum in vitro, as well as evaluated the potential of estrogenic sorghum phenolic extracts to prevent colon carcinogenesis in vivo. The thermal stability of sorghum 3-deoxyanthocyanins was also studied, to determine their suitability as functional food colorants. White and TX430 (black) sorghum extracts showed estrogenic activity in cell models predominantly expressing estrogen receptor-? (ER?) or ER? at 5 and 10 ?g/mL, respectively. The same treatments led to induction of apoptosis in cells expressing ER?. The red TX2911 sorghum did not possess these activities. Compositional analysis revealed differences in flavones and flavanones. Flavones with estrogen-like properties, i.e. luteolin and apigenin, were detected in White and TX430 (black) sorghum extracts, but not in red TX2911 extract. Naringenin, a flavanone known to antagonize ER? signalling, was only detected in the red TX2911 extract. Additional experiments with sorghum extracts of distinct flavones/flavanone ratio, as well as with pure apigenin and naringenin, suggested that flavones are the more potent ER? agonists in sorghum. On the other hand, 3-deoxyanthocyanins were probably not estrogenic. Estrogenic white and black sorghum phenolic extracts (fed at 1% level in the diet) reduced the number of azoxymethane induced colon premalignant lesion (aberrant crypt foci) by 39.3% and 14.7%, respectively, in ovariectomized mice. Further studies are needed to elucidate the protective mechanisms induced by these sorghum extracts. Sorghum 3-deoxyanthocyanins retained good color stability after 30 minutes of heat treatment at 121 ?C under pressure: More than 80% of color retained in pH 1 and 2 HCl and citric acid solutions, and 39-84% retained from pHs 3-7. Formic acid negatively affected the color stability at pH 1 and pH 2 due to its reducing capacity. Methoxylation decreased the thermal stability of 3-deoxyanthocyanins. The heat stability of 3-deoxyanthocyanins indicates good potential for food use. Overall, the inherent estrogenic activity of specific sorghum phenolic extracts is a likely mechanism for colon cancer prevention. Further studies are needed to assess physiologically relevant dietary level of sorghum phenolics for prevention of colon cancer, and effect of food processing on the activity and bioavailability of the chemopreventive components. Advisors/Committee Members: Awika, Joseph M. (advisor), Allred, Clinton D. (advisor), Talcott, Stephen T. (committee member), Rooney, Lloyd W. (committee member).

Subjects/Keywords: sorghum; polyphenols; estrogenic activity; colon cancer

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yang, L. (2013). Estrogenic Properties of Sorghum Phenolics: Possible Role in Colon Cancer Prevention. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/151237

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yang, Liyi. “Estrogenic Properties of Sorghum Phenolics: Possible Role in Colon Cancer Prevention.” 2013. Thesis, Texas A&M University. Accessed February 16, 2020. http://hdl.handle.net/1969.1/151237.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yang, Liyi. “Estrogenic Properties of Sorghum Phenolics: Possible Role in Colon Cancer Prevention.” 2013. Web. 16 Feb 2020.

Vancouver:

Yang L. Estrogenic Properties of Sorghum Phenolics: Possible Role in Colon Cancer Prevention. [Internet] [Thesis]. Texas A&M University; 2013. [cited 2020 Feb 16]. Available from: http://hdl.handle.net/1969.1/151237.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yang L. Estrogenic Properties of Sorghum Phenolics: Possible Role in Colon Cancer Prevention. [Thesis]. Texas A&M University; 2013. Available from: http://hdl.handle.net/1969.1/151237

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

27. Ritchie, Lauren E. Diet, Disease State, and the Space Environment Modify the Intestinal Microbiota and Mucosal Environment via Microbiota-directed Alterations in Colonocyte Signalling.

Degree: 2013, Texas A&M University

URL: http://hdl.handle.net/1969.1/151706

► Microbial dysbiosis and toll-like receptor (TLR) signaling play a role in colonic injury and inflammation. Ulcerative colitis and radiation are known to alter microbiota, and… (more)

▼ Microbial dysbiosis and toll-like receptor (TLR) signaling play a role in colonic injury and inflammation. Ulcerative colitis and radiation are known to alter microbiota, and diets containing polyphenols impact bacterial populations. We hypothesized that diet can mitigate dextran sodium sulfate (DSS) colitis (sorghum bran diets containing polyphenols) and space environment-induced alterations (normal iron content) in colonic microbiota and TLR signaling. To test this we utilized two experimental paradigms; DSS-induced colitis (3% DSS, 48-hr, 3 exposures, 2 wk separation), and three models to emulate the space environment: 1) fractionated low linear energy transfer (LET) ? radiation (RAD) (3 Gy) and high Fe diet (IRON) (650 mg/kg), 2) high LET Si particle exposure (50 cGy) and 1/6 G hind limb unloading (HLU), and 3) 13 d spaceflight. Bran diets upregulated proliferation, and repair protein (TFF3 and TGF?) and short chain fatty acid (SCFA) transporter (Slc16a1 and Slc5a8) expression post-DSS. Diet significantly affected 24-hr fecal butyrate production, with Cellulose and Black bran having numerically higher concentrations. Two predominant phyla were identified, Firmicutes and Bacteroidetes, and this ratio was higher in Cellulose DSS. Post DSS#3 the proportion of Bacteroidales, Clostridiales, and Lactobacillales was reduced compared to post DSS#2 for all diets. Black bran non-DSS rats had the highest richness and diversity. Colonic injury negatively correlated with the proportion of Firmicutes, Actinobacteria, and Lactobacillales, and positively correlated with Unknown and Unclassified groups. Bran diets reduced the severity of epithelial injury, maintained fecal butyrate, and prevented microbial dysbiosis and depletion during DSS-induced colitis. IRON+RAD decreased SCFA concentrations. Low and high LET radiation, HLU, IRON and spaceflight increased Bacteroidetes and decreased Firmicutes. HLU and spaceflight increased Clostridiales and decreased Lactobacillales. RAD and IRON+RAD animals had increased Lactobacillales and significantly lower Clostridiales compared to CON and IRON. TLR9 and IL-6 were downregulated by RAD. TLR4, TFF3 and TGF? differentially changed with IRON and spaceflight. Microgravity independently affected the microbiota, regardless of radiation energy or dose. Each environmental insult differentially altered the microbiota and mucosal gene expression, with distinct diet, microgravity, and radiation effects observed. Bran diets mitigated deleterious effects of colitis, maintained barrier integrity, and prevented microbiota dysbiosis. Advisors/Committee Members: Turner, Nancy D (advisor), Lupton, Joanne R (committee member), Chapkin, Robert S (committee member), Riggs, Penny K (committee member), Sturino, Joseph M (committee member).

Subjects/Keywords: polyphenols; microbiota; radiation; microgravity; ulcerative colitis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ritchie, L. E. (2013). Diet, Disease State, and the Space Environment Modify the Intestinal Microbiota and Mucosal Environment via Microbiota-directed Alterations in Colonocyte Signalling. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/151706

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ritchie, Lauren E. “Diet, Disease State, and the Space Environment Modify the Intestinal Microbiota and Mucosal Environment via Microbiota-directed Alterations in Colonocyte Signalling.” 2013. Thesis, Texas A&M University. Accessed February 16, 2020. http://hdl.handle.net/1969.1/151706.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ritchie, Lauren E. “Diet, Disease State, and the Space Environment Modify the Intestinal Microbiota and Mucosal Environment via Microbiota-directed Alterations in Colonocyte Signalling.” 2013. Web. 16 Feb 2020.

Vancouver:

Ritchie LE. Diet, Disease State, and the Space Environment Modify the Intestinal Microbiota and Mucosal Environment via Microbiota-directed Alterations in Colonocyte Signalling. [Internet] [Thesis]. Texas A&M University; 2013. [cited 2020 Feb 16]. Available from: http://hdl.handle.net/1969.1/151706.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ritchie LE. Diet, Disease State, and the Space Environment Modify the Intestinal Microbiota and Mucosal Environment via Microbiota-directed Alterations in Colonocyte Signalling. [Thesis]. Texas A&M University; 2013. Available from: http://hdl.handle.net/1969.1/151706

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

28. Ren, Siqian. The effects of polyphenols from grapes to prevent cardiovascular disease.

Degree: MPH, 2013, University of Hong Kong

URL: Ren, S. [任思倩]. (2013). The effects of polyphenols from grapes to prevent cardiovascular disease. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5098840 ; http://dx.doi.org/10.5353/th_b5098840 ; http://hdl.handle.net/10722/193801

►

Background: Cardiovascular disease is the leading cause of mortality and morbidity in the world and has something to do with daily diet. The polyphenol is… (more)

▼

Background: Cardiovascular disease is the leading cause of mortality and morbidity in the world and has something to do with daily diet. The polyphenol is the most abundant compound in daily diet, including grape. The red wine was rich in polyphenol because of composing much grape. Early study has already confirmed the “French Paradox” in cardiovascular protection power, which shed light on the dietary modulation on disease. Objective: The main objective of the study was to evaluate the effect of products containing polyphenol such as red wine extract, grape juice and grape extract tablets or powder on cardiovascular disease risk factors. It mainly examined relationship between polyphenol and serum lipid in addition to blood pressure. Methods: Studies working on effects of grape extract products on cardiovascular disease were searched from electronic resources MEDLINE and EMBASE. Nine clinical controlled trials were identified through PubMed and Ovid. CONSORT guideline and Jadad Score were used to appraise the quality of trials. Weighing two assessment guidelines, a total of three studies were in good quality, one was in bad quality while the rest four were fair to middle. Results: The changes before and after intervention on serum lipid and blood pressure were contradictory. Some studies found polyphenol was statistically significant protective factors, while some did not find it siginificant but still showed a protective effect. One study found polyohenol had no effect on cardiovascular disease risk factors. Conclusion: The prevention of polyphenol was not consistent in nine trials and there is no sufficient and strong evidence supporting its cardiovascular protection effect given that the study design of each trial differed. It was not recommeded to use grape polyphenol as cardiovascular protect products. There were limitations and weakness of current study on the association of polyphenol and cardiovascular disease. Further research on this topic is required, both in vivo and in vitro.

published_or_final_version

Public Health

Master

Master of Public Health

Subjects/Keywords: Polyphenols - Physiological effect; Cardiovascular system - Diseases - Prevention

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ren, S. (2013). The effects of polyphenols from grapes to prevent cardiovascular disease. (Masters Thesis). University of Hong Kong. Retrieved from Ren, S. [任思倩]. (2013). The effects of polyphenols from grapes to prevent cardiovascular disease. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5098840 ; http://dx.doi.org/10.5353/th_b5098840 ; http://hdl.handle.net/10722/193801

Chicago Manual of Style (16^th Edition):

Ren, Siqian. “The effects of polyphenols from grapes to prevent cardiovascular disease.” 2013. Masters Thesis, University of Hong Kong. Accessed February 16, 2020. Ren, S. [任思倩]. (2013). The effects of polyphenols from grapes to prevent cardiovascular disease. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5098840 ; http://dx.doi.org/10.5353/th_b5098840 ; http://hdl.handle.net/10722/193801.

MLA Handbook (7^th Edition):

Ren, Siqian. “The effects of polyphenols from grapes to prevent cardiovascular disease.” 2013. Web. 16 Feb 2020.

Vancouver:

Ren S. The effects of polyphenols from grapes to prevent cardiovascular disease. [Internet] [Masters thesis]. University of Hong Kong; 2013. [cited 2020 Feb 16]. Available from: Ren, S. [任思倩]. (2013). The effects of polyphenols from grapes to prevent cardiovascular disease. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5098840 ; http://dx.doi.org/10.5353/th_b5098840 ; http://hdl.handle.net/10722/193801.

Council of Science Editors:

Ren S. The effects of polyphenols from grapes to prevent cardiovascular disease. [Masters Thesis]. University of Hong Kong; 2013. Available from: Ren, S. [任思倩]. (2013). The effects of polyphenols from grapes to prevent cardiovascular disease. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5098840 ; http://dx.doi.org/10.5353/th_b5098840 ; http://hdl.handle.net/10722/193801

29. Reddy, Chandrasekhar B. Polyphenols extraction characterization and encapsulation from medicinal plants; -.

Degree: Bioseparation Technology, 2014, VIT University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/37756

Abstract avalible

Reference and Publication given

Advisors/Committee Members: Noor, Ayesha.

Subjects/Keywords: characterization; extraction; Polyphenols

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Reddy, C. B. (2014). Polyphenols extraction characterization and encapsulation from medicinal plants; -. (Thesis). VIT University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/37756

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Reddy, Chandrasekhar B. “Polyphenols extraction characterization and encapsulation from medicinal plants; -.” 2014. Thesis, VIT University. Accessed February 16, 2020. http://shodhganga.inflibnet.ac.in/handle/10603/37756.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Reddy, Chandrasekhar B. “Polyphenols extraction characterization and encapsulation from medicinal plants; -.” 2014. Web. 16 Feb 2020.

Vancouver:

Reddy CB. Polyphenols extraction characterization and encapsulation from medicinal plants; -. [Internet] [Thesis]. VIT University; 2014. [cited 2020 Feb 16]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/37756.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Reddy CB. Polyphenols extraction characterization and encapsulation from medicinal plants; -. [Thesis]. VIT University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/37756

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toledo

30. Sendamangalam, Varunraj. Antibiofouling Effect of Polyphenols on Streptococcus Biofilms.

Degree: MS, Bioengineering, 2010, University of Toledo

URL: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1279305864

► Biofouling is a process of surface colonization of microorganisms that adhere to various surfaces, by producing extracellular polymers (polysaccharides and proteins, exopolymers hereafter). Dental… (more)

▼ Biofouling is a process of surface colonization of microorganisms that adhere to various surfaces, by producing extracellular polymers (polysaccharides and proteins, exopolymers hereafter). Dental plaque is one such example. It often causes serious problems in chemical, medical and pharmaceutical industries. Recently, we demonstrated that some natural phenolic compounds found in plants have an antibiofouling effect on Gram-negative bacteria biofilm formation. In this study, we tested the antibiofouling activities of three natural polyphenols; gallic acid, tannic acid, and quercetin. Ascorbic acid (vitamin C) and salicylic acid were also tested for comparison. Most natural polyphenols are antimicrobial and antioxidant also. To distinguish the antibiofouling effect of the polyphenols from their antimicrobial effects, first antimicrobial activities of the polyphenols were investigated in a separate experimental setting. A plate dilution assay was used to assay the antimicrobial effect of the polyphenols. The concentrations of the polyphenols to be used in antibiofouling tests were determined as minimum inhibitory concentrations (MICs) below which the microorganisms didn’t die. As these polyphenols are well known as strong antioxidants, it was suggested that the antimicrobial effect may be caused by the polyphenols’ antioxidant effect. To verify the contribution of antioxidant capacity to the antimicrobial effect, DMPD and ABTS decolorizing assays were used to evaluate the antioxidant activities. The results indicate that there are relations between the antimicrobial effect and antioxidant capacity of polyphenols. The antibiofouling activities of polyphenols were measured using a modified micro-titer plate assay. The polyphenols at the concentrations lesser than the minimum inhibitory concentration (MIC) were observed to reduce the biofilm formation. It was hypothesized that the reduction of biofilm in the presence of the polyphenols was due to the inhibition of exopolymers-producing enzymes by the polyphenols. Glucosyltransferase and Fructosyl transferse enzymes produced by Streptococcus mutans are responsible for exopolymers production, and exopolymers are a major component in biofilm formation. Glucosyltransferases and Fructosyltransferases were separated from a culture medium, and then tested for inhibition by the polyphenols. All the polyphenols were observed to inhibit the enzymes, and when they were inhibited, much less biofilms were formed on a solid surface. The polyphenols investigated in this study killed the S. mutans via antioxidant activities, and reduced biofilm formation through inhibition of exopolymers-producing enzymes, glucosyltransferase and fructosyltransferase. It was hypothesized that the exopolymers-producing enzymes were inhibited by the polyphenols, and as a result, exopolymers were not synthesized and no biofilms were formed. Results suggested that these polyphenols were not only good antimicrobials but also very good antioxidants and antifouling agents. Advisors/Committee Members: Kim, Dong-Shik (Committee Chair), Seo, Youngwoo (Committee Co-Chair).

Subjects/Keywords: MIC; antioxidants; antimicrobials; glucosyltransferase; polyphenols; biofilm; exopolymer.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sendamangalam, V. (2010). Antibiofouling Effect of Polyphenols on Streptococcus Biofilms. (Masters Thesis). University of Toledo. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=toledo1279305864

Chicago Manual of Style (16^th Edition):

Sendamangalam, Varunraj. “Antibiofouling Effect of Polyphenols on Streptococcus Biofilms.” 2010. Masters Thesis, University of Toledo. Accessed February 16, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1279305864.

MLA Handbook (7^th Edition):

Sendamangalam, Varunraj. “Antibiofouling Effect of Polyphenols on Streptococcus Biofilms.” 2010. Web. 16 Feb 2020.

Vancouver:

Sendamangalam V. Antibiofouling Effect of Polyphenols on Streptococcus Biofilms. [Internet] [Masters thesis]. University of Toledo; 2010. [cited 2020 Feb 16]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1279305864.

Council of Science Editors:

Sendamangalam V. Antibiofouling Effect of Polyphenols on Streptococcus Biofilms. [Masters Thesis]. University of Toledo; 2010. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1279305864

		in
And / Or
		in
And / Or
		in
And / Or
		in

Open Access Theses and Dissertations