subject:(Polymorphism)

University of Waikato

1. Mulholland, Claire Vignette. Single nucleotide polymorphisms associated with the human electroencephalogram during desflurane anaesthesia .

Degree: 2012, University of Waikato

URL: http://hdl.handle.net/10289/6678

► General anaesthesia is an induced state that enables a person to endure surgical procedures without pain or recollection. There is substantial individual variability in the… (more)

▼ General anaesthesia is an induced state that enables a person to endure surgical procedures without pain or recollection. There is substantial individual variability in the response to anaesthesia and in order to avoid adverse effects caused by either under- or over-sedation, anaesthetic drug administration must be tailored to suit the individual patient. This requires a means to monitor the depth of general anaesthesia. The electroencephalogram (EEG) records the electrical activity of the brain and enables effects of anaesthetic drugs on brain functioning to be monitored. Quantitative EEG monitors, such as the Bispectral (BIS) index monitor, process the raw EEG and provide a numerical output that is often used to measure the depth of general anaesthesia during surgery. Due to a number of factors including clinical conditions and genetic variability in the EEG, the BIS value can at times be misleading. To identify genetic variations associated with EEG phenotypes relevant to anaesthesia monitoring, an association analysis was performed for 34 single nucleotide polymorphisms (SNPs) in a sample of 125 surgical patients undergoing general, gynaecological or orthopaedic surgery. During surgery, patients were anaesthetised with the volatile anaesthetic agent desflurane, the depth of anaesthesia was measured using BIS monitoring and the raw was also EEG recorded. SNP genotyping was performed for 13 SNPs in five candidate genes; SGIP1, GABRA2, CACNA1G, HCN1 and HCN2, using the polymerase chain reaction and restriction fragment length polymorphism analysis. An additional 21 SNPs in 15 genes involved in various inflammatory and other immune-related pathways were genotyped by Sequenom MassARRAY at the Australian Genome Research Facility. Six SNPs in five different genes were found to be associated with spindle amplitude (SGIP1, GABRA2, HCN1, IL1B and MYD88), and a further five SNPs were associated with either delta frequency (IL10), or end tidal desflurane concentration (ETDC) (CACNA1G, CRP, MYD88 and TGFB1). The strongest associations were identified for a single SNP located in the 3' UTR of MYD88 (rs6853). The rs6853 A/G genotype was associated with higher median spindle amplitude (p = 0.0040) and spindle amplitude relative to ETDC (p = 0.0006), and lower EDTC (p = 0.0095) than the A/A genotype. No rs6853 G/G homozygotes were identified in the study sample. MYD88 acts as an adaptor protein in the interleukin-1 receptor and toll-like receptor signalling pathways. Within the brain, cytokines are thought to act as neuronal modulators and influence neurotransmitter signalling and ion channel activity. The association of MYD88 with spindle amplitude, in conjunction with IL1B, suggests that cytokines may influence the EEG during general anaesthesia. Thus cytokine mediated regulation of neuronal activity is speculated to underlie the reported associations. All reported effect sizes were small (0.77- to 1.55-fold) and associated genes had four distinct types of function; ion channels, neurotransmitter signalling, endocytosis,… Advisors/Committee Members: Cursons, Raymond T (advisor).

Subjects/Keywords: single nucleotide polymorphism; polymorphism; SNP; anaesthesia; electroencephalogram

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mulholland, C. V. (2012). Single nucleotide polymorphisms associated with the human electroencephalogram during desflurane anaesthesia . (Masters Thesis). University of Waikato. Retrieved from http://hdl.handle.net/10289/6678

Chicago Manual of Style (16^th Edition):

Mulholland, Claire Vignette. “Single nucleotide polymorphisms associated with the human electroencephalogram during desflurane anaesthesia .” 2012. Masters Thesis, University of Waikato. Accessed February 27, 2020. http://hdl.handle.net/10289/6678.

MLA Handbook (7^th Edition):

Mulholland, Claire Vignette. “Single nucleotide polymorphisms associated with the human electroencephalogram during desflurane anaesthesia .” 2012. Web. 27 Feb 2020.

Vancouver:

Mulholland CV. Single nucleotide polymorphisms associated with the human electroencephalogram during desflurane anaesthesia . [Internet] [Masters thesis]. University of Waikato; 2012. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/10289/6678.

Council of Science Editors:

Mulholland CV. Single nucleotide polymorphisms associated with the human electroencephalogram during desflurane anaesthesia . [Masters Thesis]. University of Waikato; 2012. Available from: http://hdl.handle.net/10289/6678

2. Μανίκα, Γεωργία. Πολυμορφισμός Aripiprazole και μέθοδοι ταυτοποίησης και ποσοστικής ανάλυσης.

Degree: 2014, University of Patras

URL: http://hdl.handle.net/10889/8004

► Several active pharmaceutical ingredients (API) exhibit polymorphism i.e. the ability of a solid material to exist in more than one form or crystal structure (polymorphs).… (more)

▼ Several active pharmaceutical ingredients (API) exhibit polymorphism i.e. the ability of a solid material to exist in more than one form or crystal structure (polymorphs). The polymorphs differ somewhat in physical and, sometimes, chemical properties, although their solutions and vapours are identical. Among the different physical properties that are affected by polymorphism are solubility and dissolution rate which have great impact on the bioavailability of the drug. Frequently an API polymorph transforms to another, more thermodynamically stable, phase. When such transformation takes place then a pharmaceutical industry faces problems related to bioavailability of an API as well as litigation problems due to patent protection of specific polymorphs. The pharmaceutical substance that was studied in this current work was, Aripiprazole, an antipsychotic drug. API crystallizes in a large number of polymorphic and solvatomorphic phases. Μore specific 9 polymorphic and 9 solvatomorphic phases have been positively identified, from which Form III and Form V are currently tested as possible candidates for drug formulations. The objective of the present work was to establish methods capable of identification and quantification of Apiprazole crystal forms and their possible transformation to hydrate phase in Aripiprazole powders as well as in the tested tablets. Stability test were also performed on Aripiprazole crystal forms III and V. The analytical techniques applied were X-ray Powder Diffraction (XRPD), Infrared spectroscopy (IR) and Raman spectroscopy. Calibration lines of mixtures of API Form III and Monohydrate were constructed. Results show that all three techniques were capable of identifying and quantifying the monohydrate phase however XRPD is probably the method of choice due to the lower detection limit (0.34%) of monohydrate in Phase III-monohydrate mixtures. Quantitative analysis of these polymorphs in the presence of excipients (tablets) is difficult due to the rather low API percentage in tablets (8%) and the high detection limits of monohydrate in mixtures of III and monohydrate. An effort to increase the low API content was made by dissolving in water a large percentage of excipients at alkaline pH. Even though the stability tests show that no transformation of pure Phase III occurs under these conditions, in tablets with some presence of monohydrate, rapid transformation of the remaining Phase III was observed during the dissolution process of the excipients. Thus, the only way was to apply directly the analytical techniques that were used for the pure mixtures to tablets. It was found that Raman and IR spectra cannot be used due to heavy overlapping with excipients bands. By increasing the scan time the identification of anhydrate phase and the hydrate was possible by using XRPD. In order to avoid any possible transformation of both Form III and Form V (stability tests show transformation to hydrate phase) it was decided to build the calibration line using only the hydrate phase and the placebo. The… Advisors/Committee Members: Κοντογιάννης, Χρίστος, Manika, Georgia, Όρκουλα, Μαλβίνα, Κλεπετσάνης, Παύλος, Κοντογιάννης, Χρίστος.

Subjects/Keywords: Polymorphism; Aripiprazole; Πολυμορφισμός

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Μανίκα, �. (2014). Πολυμορφισμός Aripiprazole και μέθοδοι ταυτοποίησης και ποσοστικής ανάλυσης. (Masters Thesis). University of Patras. Retrieved from http://hdl.handle.net/10889/8004

Chicago Manual of Style (16^th Edition):

Μανίκα, Γεωργία. “Πολυμορφισμός Aripiprazole και μέθοδοι ταυτοποίησης και ποσοστικής ανάλυσης.” 2014. Masters Thesis, University of Patras. Accessed February 27, 2020. http://hdl.handle.net/10889/8004.

MLA Handbook (7^th Edition):

Μανίκα, Γεωργία. “Πολυμορφισμός Aripiprazole και μέθοδοι ταυτοποίησης και ποσοστικής ανάλυσης.” 2014. Web. 27 Feb 2020.

Vancouver:

Μανίκα �. Πολυμορφισμός Aripiprazole και μέθοδοι ταυτοποίησης και ποσοστικής ανάλυσης. [Internet] [Masters thesis]. University of Patras; 2014. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/10889/8004.

Council of Science Editors:

Μανίκα �. Πολυμορφισμός Aripiprazole και μέθοδοι ταυτοποίησης και ποσοστικής ανάλυσης. [Masters Thesis]. University of Patras; 2014. Available from: http://hdl.handle.net/10889/8004

University of Manchester

3. Dowling, Richard John. A study of the nucleation and growth of glycine and DL-alanine.

Degree: PhD, 2012, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/a-study-of-the-nucleation-and-growth-of-glycine-and-dlalanine(a8af960d-43e1-4ef8-a552-53dee7a03f76).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555540

► A clear and predictive understanding of the propensity for crystallisation of one polymorph over another is lacking, and in this regard glycine is a model… (more)

▼ A clear and predictive understanding of the propensity for crystallisation of one polymorph over another is lacking, and in this regard glycine is a model system due to difficulties in crystallisation of the thermodynamically stable gamma polymorph. The preferential crystallisation of gamma-glycine in the presence of micellar CTAB (Cetyltrimethylammonium bromide) as opposed to the alpha form commonly crystallised from pure solution was observed. A rationale for this result was sought through the observation of the nucleation and growth kinetics of the alpha and gamma polymorphs of glycine (and DL-alanine) using in situ microscopy, the measurement of induction times and following the solution mediated phase transformation of alpha-glycine. These observations help explain the dominant crystal form produced in a number of solutions. The nucleation and growth rates of alpha-glycine were shown to be orders of magnitude greater than those of gamma-glycine in pure solution. Also, the addition of a cationic surfactant (such as CTAB) or modification of the solution pH were shown to dramatically accelerate the nucleation and growth of polar gamma-glycine and DL-alanine, a rarely reported phenomenon. In addition, the growing (00-1) faces of gamma-glycine and DL-alanine, at which growth was accelerated, were shown to be macroscopically rough, indicating a growth mechanism dominated by nucleation rather than the growth of layers. The most likely cause of the inhibited kinetics of gamma-glycine and DL-alanine is water bound electrostatically at the negatively charged (00-1) faces, while the growth acceleration inferred by the additives is related to their ability to release water from these surfaces. Other mechanisms which may play a role include the adsorption of adventitious impurities, strong electrostatic repulsion between like-charged carboxylate groups at the (00-1) surface resulting in structural disorder, and the effect of surface energy on the rate of surface nucleation. This research provides an important example of nature’s complexity in selecting crystal form in polymorphic systems, gives further insight into the causes of the asymmetric growth of polar crystal structures, and introduces the possibility that the crystallisation kinetics of ‘difficult’ slow growing compounds may sometimes be modified through the use of additives.

Subjects/Keywords: 548; Polymorphism; Kinetics

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dowling, R. J. (2012). A study of the nucleation and growth of glycine and DL-alanine. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/a-study-of-the-nucleation-and-growth-of-glycine-and-dlalanine(a8af960d-43e1-4ef8-a552-53dee7a03f76).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555540

Chicago Manual of Style (16^th Edition):

Dowling, Richard John. “A study of the nucleation and growth of glycine and DL-alanine.” 2012. Doctoral Dissertation, University of Manchester. Accessed February 27, 2020. https://www.research.manchester.ac.uk/portal/en/theses/a-study-of-the-nucleation-and-growth-of-glycine-and-dlalanine(a8af960d-43e1-4ef8-a552-53dee7a03f76).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555540.

MLA Handbook (7^th Edition):

Dowling, Richard John. “A study of the nucleation and growth of glycine and DL-alanine.” 2012. Web. 27 Feb 2020.

Vancouver:

Dowling RJ. A study of the nucleation and growth of glycine and DL-alanine. [Internet] [Doctoral dissertation]. University of Manchester; 2012. [cited 2020 Feb 27]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/a-study-of-the-nucleation-and-growth-of-glycine-and-dlalanine(a8af960d-43e1-4ef8-a552-53dee7a03f76).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555540.

Council of Science Editors:

Dowling RJ. A study of the nucleation and growth of glycine and DL-alanine. [Doctoral Dissertation]. University of Manchester; 2012. Available from: https://www.research.manchester.ac.uk/portal/en/theses/a-study-of-the-nucleation-and-growth-of-glycine-and-dlalanine(a8af960d-43e1-4ef8-a552-53dee7a03f76).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555540

Univerzitet u Beogradu

4. Živanović, Dubravka P., 1970-. Polimorfizam HLA-DR i HLA-DQ alela kod pacijenata sa pemfigus vulgarisom.

Degree: Medicinski fakultet, 2016, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:14064/bdef:Content/get

►

Medicina - Dermatovenerologija / Medicine - Dermatology

Uvod: Pemphigus vulgaris (PV) pripada grupi organ specifičnih autoimunskih oboljenja, kod koga se stvaraju autoantitela usmerena na specifične… (more)

▼

Medicina - Dermatovenerologija / Medicine - Dermatology

Uvod: Pemphigus vulgaris (PV) pripada grupi organ specifičnih autoimunskih oboljenja, kod koga se stvaraju autoantitela usmerena na specifične proteine (antigene) kože i sluzokoža. Autoantitela kod pemfigusa su usmerena prema komponentama međućelijskih spojeva (dezmozomima). To su dezmoglein 3 (Dsg 3), u manjoj meri dezmoglein 1 (Dsg 1) i drugi proteini. Kao posledica vezivanja cirkulišućih antitela za proteine dezmozoma dolazi do cepanja međućelijskih spojeva (akantolize) i pojave plikova (bula) na koži i sluzokožama. Autoimunski pemfigus, kao i druge autoimunske bolesti, predstavlja multifaktorsko oboljenje, rizik od nastanka bolesti zavisi od složenih interakcija gena i faktora spoljašnje sredine. U okviru naslednih faktora u etiopatogenezi pemfigusa najviše je ispitivan kompleks gena tkivne podudarnosti koji kodira sistem humanih leukocitnih antigena (HLA). HLA je najpolimorfniji deo humanog genoma. Složenost polimorfizma HLA je posledica postojanja više genskih lokusa, velikog broja alela za većinu gena i kombinacija produkata ovih alela. HLA molekuli II klase su posebno značajni jer prikazuju peptide CD4+ T-limfocitima pod čijom kontrolom je sekrecija anti Dsg 3 i anti Dsg 1 antitela od strane B-limfocita. Do sada je dokazana udruženost pojedinih HLA alela sa većim brojem autoimunskih oboljenja uključujući i pemfigus. Ciljevi istraživanja: Ciljevi ovog istraživanja su bili da se ustanovi učestalost alela i haplotipova u HLA-DR i DQ lokusima kod pacijenata sa PV u Srbiji, da se ustanovi stepen genetske sličnosti sa obolelima od PV u drugim populacijama, kao i da se ispita korelacija između genotipova, težine bolesti i koncentracije Dsg1 i Dsg3 antitela. Ispitanici i metode: Ispitivanje je izvršeno kod 72 pacijenta sa dokazanim PV. Kod ispitanika je određena alelska učestalost u HLA-DR i DQ lokusima (DRB1*, DQB1* i DQA1*). Izolacija DNK je rađena upotrebom QIAamp DNA Blood Mini Kit-a (QIAGEN, Germany). Određivanje grupa alela ispitivanih lokusa je rađeno testovima niske/srednje rezolucije, a potom su testovima visoke rezolucije određivani aleli upotrebom prajmera specifičnih za alelsku sekvencu PCR-SSP (engl. Polymerase chain reaction with sequence-specific primers) prema preporukama proizvođača testova (BAG lich Germany i Invitrogen)...

Advisors/Committee Members: Medenica, Ljiljana, 1951-.

Subjects/Keywords: HLA; polymorphism; pemphigus

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Živanović, Dubravka P., 1. (2016). Polimorfizam HLA-DR i HLA-DQ alela kod pacijenata sa pemfigus vulgarisom. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:14064/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Živanović, Dubravka P., 1970-. “Polimorfizam HLA-DR i HLA-DQ alela kod pacijenata sa pemfigus vulgarisom.” 2016. Thesis, Univerzitet u Beogradu. Accessed February 27, 2020. https://fedorabg.bg.ac.rs/fedora/get/o:14064/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Živanović, Dubravka P., 1970-. “Polimorfizam HLA-DR i HLA-DQ alela kod pacijenata sa pemfigus vulgarisom.” 2016. Web. 27 Feb 2020.

Vancouver:

Živanović, Dubravka P. 1. Polimorfizam HLA-DR i HLA-DQ alela kod pacijenata sa pemfigus vulgarisom. [Internet] [Thesis]. Univerzitet u Beogradu; 2016. [cited 2020 Feb 27]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:14064/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Živanović, Dubravka P. 1. Polimorfizam HLA-DR i HLA-DQ alela kod pacijenata sa pemfigus vulgarisom. [Thesis]. Univerzitet u Beogradu; 2016. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:14064/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Georgia

5. Sprolden, Tracy Lashonda. Double eQTL mapping method to improve identification of trans eQTLs and construct intermediate gene networks.

Degree: MS, Statistics, 2013, University of Georgia

URL: http://purl.galileo.usg.edu/uga_etd/sprolden_tracy_l_201305_ms

► A double eQTL mapping method for identifying trans eQTLs that reduces multiple testing and increases the statistical power of eQTL mapping is described. The first… (more)

Subjects/Keywords: Single nucleotide polymorphism (SNP)

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sprolden, T. L. (2013). Double eQTL mapping method to improve identification of trans eQTLs and construct intermediate gene networks. (Masters Thesis). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/sprolden_tracy_l_201305_ms

Chicago Manual of Style (16^th Edition):

Sprolden, Tracy Lashonda. “Double eQTL mapping method to improve identification of trans eQTLs and construct intermediate gene networks.” 2013. Masters Thesis, University of Georgia. Accessed February 27, 2020. http://purl.galileo.usg.edu/uga_etd/sprolden_tracy_l_201305_ms.

MLA Handbook (7^th Edition):

Sprolden, Tracy Lashonda. “Double eQTL mapping method to improve identification of trans eQTLs and construct intermediate gene networks.” 2013. Web. 27 Feb 2020.

Vancouver:

Sprolden TL. Double eQTL mapping method to improve identification of trans eQTLs and construct intermediate gene networks. [Internet] [Masters thesis]. University of Georgia; 2013. [cited 2020 Feb 27]. Available from: http://purl.galileo.usg.edu/uga_etd/sprolden_tracy_l_201305_ms.

Council of Science Editors:

Sprolden TL. Double eQTL mapping method to improve identification of trans eQTLs and construct intermediate gene networks. [Masters Thesis]. University of Georgia; 2013. Available from: http://purl.galileo.usg.edu/uga_etd/sprolden_tracy_l_201305_ms

University of Georgia

6. Gatlin, Michael Richard. Cytokine gene polymorphisms associated with resistance vs. susceptibility to reinfection with Schistosoma mansoni.

Degree: PhD, Microbiology, 2009, University of Georgia

URL: http://purl.galileo.usg.edu/uga_etd/gatlin_michael_r_200905_phd

► The immunologic findings that most consistently correlate with resistance in human schistosomiasis are high levels of IgE and low levels of IgG4. We have genotyped… (more)

▼ The immunologic findings that most consistently correlate with resistance in human schistosomiasis are high levels of IgE and low levels of IgG4. We have genotyped gene and promoter polymorphisms of cytokines associated with regulation of these isotypes in a cohort of men occupationally exposed to Schistosoma mansoni in western Kenya and evaluated their patterns with respect to resistance and susceptibility to reinfection after treatment and cure with praziquantel (PZQ). In this cohort, polymorphisms in IL-4 (−590T high IgE), IL-13 (−1055T high producer) and IFN-γ (+874A high producer) demonstrated several correlations with resistance to reinfection. Resistance to reinfection was significantly correlated with the heterozygous IL-4 −590 genotype C/T (OR 3.5, [CI 1.2, 10.2]) compared to T/T. Among men with a homozygous IL-13 genotype CC/TT, having a T allele at the IFN- +874 position increased the odds of resistance relative to individuals with the IFN- +874 A/A genotype (OR=17.5 [CI 3.0, 101.5]). Among men with homozygous A/A IFN- genotype, the heterozygous IL-13 genotype C/T was associated with resistance relative to the homozygous C/C or T/T genotypes (OR=22.5 [CI 3.5, 144.4]). No increases in odds of resistance were found in relation to the IL-13 genotype among those with a T allele in the IFN- gene or in relation to the IFN- genotype among those with a heterozygous IL-13 genotype. Calculation of the attributable proportion of resistance showed a significant synergistic interaction between IL-13 −1055 C/T and IL-4 −590 C/T. The identified polymorphisms do not by themselves confer resistance or susceptibility, but we propose that these genotypes allow the resistant phenotype to be developed and expressed upon suitable immune exposure. Based on the literature, these polymorphisms contribute to the regulation of their respective cytokines, likely leading to downstream differences in the production and interrelationships of critical defense mechanisms. Advisors/Committee Members: Daniel Colley.

Subjects/Keywords: Schistosoma mansoni; polymorphism; resistance; cytokine

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gatlin, M. R. (2009). Cytokine gene polymorphisms associated with resistance vs. susceptibility to reinfection with Schistosoma mansoni. (Doctoral Dissertation). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/gatlin_michael_r_200905_phd

Chicago Manual of Style (16^th Edition):

Gatlin, Michael Richard. “Cytokine gene polymorphisms associated with resistance vs. susceptibility to reinfection with Schistosoma mansoni.” 2009. Doctoral Dissertation, University of Georgia. Accessed February 27, 2020. http://purl.galileo.usg.edu/uga_etd/gatlin_michael_r_200905_phd.

MLA Handbook (7^th Edition):

Gatlin, Michael Richard. “Cytokine gene polymorphisms associated with resistance vs. susceptibility to reinfection with Schistosoma mansoni.” 2009. Web. 27 Feb 2020.

Vancouver:

Gatlin MR. Cytokine gene polymorphisms associated with resistance vs. susceptibility to reinfection with Schistosoma mansoni. [Internet] [Doctoral dissertation]. University of Georgia; 2009. [cited 2020 Feb 27]. Available from: http://purl.galileo.usg.edu/uga_etd/gatlin_michael_r_200905_phd.

Council of Science Editors:

Gatlin MR. Cytokine gene polymorphisms associated with resistance vs. susceptibility to reinfection with Schistosoma mansoni. [Doctoral Dissertation]. University of Georgia; 2009. Available from: http://purl.galileo.usg.edu/uga_etd/gatlin_michael_r_200905_phd

University of Hong Kong

7. 王煒欣; Wang, Weixin. A fast and accurate model to detect germline SNPs and somatic SNVs with high-throughput sequencing.

Degree: PhD, 2014, University of Hong Kong

URL: Wang, W. [王煒欣]. (2014). A fast and accurate model to detect germline SNPs and somatic SNVs with high-throughput sequencing. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5185953 ; http://dx.doi.org/10.5353/th_b5185953 ; http://hdl.handle.net/10722/197115

►

The rapid development of high-throughput sequencing technology provides a new chance to extend the scale and resolution of genomic research. How to efficiently and accurately… (more)

▼

The rapid development of high-throughput sequencing technology provides a new chance to extend the scale and resolution of genomic research. How to efficiently and accurately call genetic variants in single base level (germline single nucleotide polymorphisms (SNPs) or somatic single nucleotide variants (SNVs)) is the fundamental challenge in sequencing data analysis, because these variants reported to influence transcriptional regulation, alternative splicing, non-coding RNA regulation and protein coding. Many applications have been developed to tackle this challenge. However, the shallow depth and cellular heterogeneity make those tools cannot attain satisfactory accuracy, and the huge volume of sequencing data itself cause this process inefficient. In this dissertation, firstly the performance of prevalent reads aligners and SNP callers for second-generation sequencing (SGS) is evaluated. And due to the high GC-content, the significantly lower coverage and poorer SNP calling performance in the regulatory regions of human genome by SGS is investigated. To enhance the capability to call SNPs, especially within the lower-depth regions, a fast and accurate SNP detection (FaSD) program that uses a binomial distribution based algorithm and a mutation probability is proposed. Based on the comparison with popular software and benchmarked by SNP arrays and high-depth sequencing data, it is demonstrated that FaSD has the best SNP calling accuracy in the aspects of genotype concordance rate and AUC. Furthermore, FaSD can finish SNP calling within four hours for 10X human genome SGS data on a standard desktop computer. Lastly, combined with the joint genotype likelihoods, an updated version of FaSD is proposed to call the cancerous somatic SNVs between paired tumor and normal samples. With extensive assessments on various types of cancer, it is demonstrated that no matter benchmarked by the known somatic SNVs and germline SNPs from database, or somatic SNVs called from higher-depth data, FaSD-somatic has the best overall performance. Inherited and improved from FaSD, FaSD-somatic is also the fastest somatic SNV caller among current programs, and can finish calling somatic mutations within 14 hours for 50X paired tumor and normal samples on normal server.

published_or_final_version

Biochemistry

Doctoral

Doctor of Philosophy

Advisors/Committee Members: Wang, JJ, Lam, TW.

Subjects/Keywords: Nucleotide sequence; Chromosome polymorphism

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

王煒欣; Wang, W. (2014). A fast and accurate model to detect germline SNPs and somatic SNVs with high-throughput sequencing. (Doctoral Dissertation). University of Hong Kong. Retrieved from Wang, W. [王煒欣]. (2014). A fast and accurate model to detect germline SNPs and somatic SNVs with high-throughput sequencing. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5185953 ; http://dx.doi.org/10.5353/th_b5185953 ; http://hdl.handle.net/10722/197115

Chicago Manual of Style (16^th Edition):

王煒欣; Wang, Weixin. “A fast and accurate model to detect germline SNPs and somatic SNVs with high-throughput sequencing.” 2014. Doctoral Dissertation, University of Hong Kong. Accessed February 27, 2020. Wang, W. [王煒欣]. (2014). A fast and accurate model to detect germline SNPs and somatic SNVs with high-throughput sequencing. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5185953 ; http://dx.doi.org/10.5353/th_b5185953 ; http://hdl.handle.net/10722/197115.

MLA Handbook (7^th Edition):

王煒欣; Wang, Weixin. “A fast and accurate model to detect germline SNPs and somatic SNVs with high-throughput sequencing.” 2014. Web. 27 Feb 2020.

Vancouver:

王煒欣; Wang W. A fast and accurate model to detect germline SNPs and somatic SNVs with high-throughput sequencing. [Internet] [Doctoral dissertation]. University of Hong Kong; 2014. [cited 2020 Feb 27]. Available from: Wang, W. [王煒欣]. (2014). A fast and accurate model to detect germline SNPs and somatic SNVs with high-throughput sequencing. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5185953 ; http://dx.doi.org/10.5353/th_b5185953 ; http://hdl.handle.net/10722/197115.

Council of Science Editors:

王煒欣; Wang W. A fast and accurate model to detect germline SNPs and somatic SNVs with high-throughput sequencing. [Doctoral Dissertation]. University of Hong Kong; 2014. Available from: Wang, W. [王煒欣]. (2014). A fast and accurate model to detect germline SNPs and somatic SNVs with high-throughput sequencing. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5185953 ; http://dx.doi.org/10.5353/th_b5185953 ; http://hdl.handle.net/10722/197115

Mahatma Gandhi University

8. Nileena, C B. Detailed studies on the genera and species of the family Podostemaceae with particular reference to the phenomenon of polymorphism; -.

Degree: Botany, 2013, Mahatma Gandhi University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/6494

References p.179-190 Advisors/Committee Members: Mathew, C Joyce.

Subjects/Keywords: Botany; polymorphism

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nileena, C. B. (2013). Detailed studies on the genera and species of the family Podostemaceae with particular reference to the phenomenon of polymorphism; -. (Thesis). Mahatma Gandhi University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/6494

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nileena, C B. “Detailed studies on the genera and species of the family Podostemaceae with particular reference to the phenomenon of polymorphism; -.” 2013. Thesis, Mahatma Gandhi University. Accessed February 27, 2020. http://shodhganga.inflibnet.ac.in/handle/10603/6494.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nileena, C B. “Detailed studies on the genera and species of the family Podostemaceae with particular reference to the phenomenon of polymorphism; -.” 2013. Web. 27 Feb 2020.

Vancouver:

Nileena CB. Detailed studies on the genera and species of the family Podostemaceae with particular reference to the phenomenon of polymorphism; -. [Internet] [Thesis]. Mahatma Gandhi University; 2013. [cited 2020 Feb 27]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/6494.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nileena CB. Detailed studies on the genera and species of the family Podostemaceae with particular reference to the phenomenon of polymorphism; -. [Thesis]. Mahatma Gandhi University; 2013. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/6494

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

9. Dimitriadou, Meropi. Συσχέτιση του γονιδιακού πολυμορφισμού Fok-I του υποδοχέα της βιταμίνης D με απεικονιστικές και βιοχημικές παραμέτρους οστικού μεταβολισμού σε παιδιά και νεαρούς ενήλικες με ομόζυγη β-μεσογειακή αναιμία.

Degree: 2015, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

URL: http://hdl.handle.net/10442/hedi/35698

►

In recent years the genetic contribution on osteoporosis has been studied thoroughtly with the presence of various gene polymorphisms. We sought to estimate the degree… (more)

▼

In recent years the genetic contribution on osteoporosis has been studied thoroughtly with the presence of various gene polymorphisms. We sought to estimate the degree of genetic contribution of Fok-I gene polymorphism of Vitamin D Receptor (VDR) to the evolution of bone mass in patients with β-TM assessed with imaging techniques and biochemical parameters of bone metabolism over a period of two years. Sixty-four children and young adults (33 males and 31 females) with mean decimal age of 23.20 ± 5.41 (range: 9.25-32.41 years) were recruited in this study. All patients were genotyped for Fok-I gene polymorphism using the method of Polymerase Chain Reaction (PCR). Bone mass was assessed with both Dual energy X-ray Absorptiometry (DXA) and Quantitative Ultrasound Sonography (QUS) at baseline and two years after. Z-scores were calculated based on normal age and sex matched Caucasian population. Metabolites of vitamin D, intact PTH, total calcium, inorganic phosphorous and alkaline phosphatase were measured at serum with the specimen collected before regular transfusions. Twentynine patients were homozygous for the F allele (FF, 45.3%), twentyseven patients were heterozygotes (Ff, 42.2%) and eight patients were homozygous for the f allele (ff, 12.5%). A significant proportion of patients (15.6%) showed decreased values of DXA measured at lumbar spine (Z-score ≤ -2) at baseline and especially at the hip (31%). Α statistically significant deterioration in both sexes was observed in DXA measurements both at the femoral neck (p <0,001) and at the hip (p <0,001). A very small percentage of patients showed abnormally low SOS values measured in radius (7.8%) and only 1 patient at tibia at the beginning of the study. All patients had normal SOS values in the re-evaluation. With regards to genotyping, no deviation was observed with respect to DXA measurements, although carriers of the f allele in homozygosity clearly had better measurements compared with F carriers either in homo- or hetero-zygosity. However in retesting, DXA values at femoral neck (FF: p = 0,004 Ff: p <0,001, ff: p = 0,024) and at total hip (FF: p = 0,022, Ff: p = 0,005) deteriorated significantly in all genotypes except for ff and with regards to measurements at total hip. This finding was not replicated with regards to QUS measurements. The vast majority of patients showed insufficient (59.4%) and borderline (12.5 %) levels of vitamin D. In conclusion, the f allele in homozygosity seems to have a positive impact on evolution of bone disease in patients with b-MA. The level of agreement between the two imaging methods for identifying patients with low bone properties was poor.

Τελευταία, μελετάται η επίδραση διάφορων γονιδιακών πολυμορφισμών στην αιτιοπαθογένεια της οστικής νόσου σε ασθενείς με ομόζυγη β-ΜΑ. Σκοπός της μελέτης ήταν η διερεύνηση της επίδρασης του γονιδιακού πολυμορφισμού Fok-I του υποδοχέα της βιταμίνης D στην οστική κατάσταση παιδιών και νεαρών ενηλίκων με β-ΜΑ, όπως εκτιμήθηκε με απεικονιστικές και βιοχημικές παραμέτρους οστικού…

Subjects/Keywords: Γονιδιακός πολυμορφισμός; Gene polymorphism

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dimitriadou, M. (2015). Συσχέτιση του γονιδιακού πολυμορφισμού Fok-I του υποδοχέα της βιταμίνης D με απεικονιστικές και βιοχημικές παραμέτρους οστικού μεταβολισμού σε παιδιά και νεαρούς ενήλικες με ομόζυγη β-μεσογειακή αναιμία. (Thesis). Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Retrieved from http://hdl.handle.net/10442/hedi/35698

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dimitriadou, Meropi. “Συσχέτιση του γονιδιακού πολυμορφισμού Fok-I του υποδοχέα της βιταμίνης D με απεικονιστικές και βιοχημικές παραμέτρους οστικού μεταβολισμού σε παιδιά και νεαρούς ενήλικες με ομόζυγη β-μεσογειακή αναιμία.” 2015. Thesis, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Accessed February 27, 2020. http://hdl.handle.net/10442/hedi/35698.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dimitriadou, Meropi. “Συσχέτιση του γονιδιακού πολυμορφισμού Fok-I του υποδοχέα της βιταμίνης D με απεικονιστικές και βιοχημικές παραμέτρους οστικού μεταβολισμού σε παιδιά και νεαρούς ενήλικες με ομόζυγη β-μεσογειακή αναιμία.” 2015. Web. 27 Feb 2020.

Vancouver:

Dimitriadou M. Συσχέτιση του γονιδιακού πολυμορφισμού Fok-I του υποδοχέα της βιταμίνης D με απεικονιστικές και βιοχημικές παραμέτρους οστικού μεταβολισμού σε παιδιά και νεαρούς ενήλικες με ομόζυγη β-μεσογειακή αναιμία. [Internet] [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2015. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/10442/hedi/35698.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dimitriadou M. Συσχέτιση του γονιδιακού πολυμορφισμού Fok-I του υποδοχέα της βιταμίνης D με απεικονιστικές και βιοχημικές παραμέτρους οστικού μεταβολισμού σε παιδιά και νεαρούς ενήλικες με ομόζυγη β-μεσογειακή αναιμία. [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2015. Available from: http://hdl.handle.net/10442/hedi/35698

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Penn State University

10. Yang, Xi. Human Microsomal Epoxide Hydrolase (EPHX1): Genetic Polymorphism And Regulation By Chemopreventive Agents.

Degree: PhD, Genetics, 2009, Penn State University

URL: https://etda.libraries.psu.edu/catalog/9828

► Microsomal epoxide hydrolase (EPHX1) is a critical catalytic determinant in the formation of the highly reactive electrophilic, and ultimately carcinogenic, epoxide metabolites of the polyaromatic… (more)

▼ Microsomal epoxide hydrolase (EPHX1) is a critical catalytic determinant in the formation of the highly reactive electrophilic, and ultimately carcinogenic, epoxide metabolites of the polyaromatic hydrocarbons. A central hypothesis of our research is that genetic variability and differential regulation of EPHX1 in human tissue are likely important determinants of interindividual responsiveness, resulting toxicities, and carcinogenicity outcomes related to chemical exposures. Our laboratory has demonstrated that the expression of the human EPHX1 gene is driven by the use of alternative promoters. An alternative promoter region, termed the E1-b promoter, is localized ~ 18.5 kb 5’-upstream from the structural region of the EPHX1 gene. The E1-b promoter is used exclusively to drive expression of EPHX1 mRNA transcripts in most tissues, along with a more proximal and highly liver-specific E1 promoter. Results of quantitative Real Time-PCR analyses demonstrated that the E1-b variant transcript is preferentially and broadly expressed in most tissues, such that it accounts for the majority of total EPHX1 transcript in vivo. In the studies conducted within this thesis research, detailed analysis of the E1-b promoter region demonstrated that this upstream EPHX1 promoter is replete with transposable elements. Further, we identified that two specific Alu elements are polymorphic (i.e. some chromosomes carry the two Alu insertions, whereas other do not) in the genome structure of different individuals. Results of luciferase gene reporter assays conducted in several human cell lines with E1-b promoter constructs demonstrated that the inclusion of the Alu (+/+) insertion significantly decreases basal transcriptional activities. Although we identified a putative aryl hydrocarbon receptor (AhR) binding motif within the Alu element structure, expression of human EPHX1 in an in vitro system was only modestly responsive to AhR ligands and we conclude that AhR regulation does not associate with the presence/absence of Alu elements. Two non-synonomous genetic polymorphisms that alter the EPHX1 amino acid structure were identified in our laboratory’s previous research efforts and several epidemiologic investigations have now implicated these EPHX1 coding region polymorphisms as a risk factor for lung cancer. In this study, using haplotype block analyses, we determined that the E1-b polymorphic promoter region was not in linkage disequilibrium with two previously identified non-synonomous SNPs in the coding region or with functional SNPs previously identified in the proximal promoter region of the gene. Modulation of xenobiotic-metabolizing enzymes by chemopreventive agents is a promising strategy offering protection against toxicity mediated by certain chemical carcinogens. In this research, we discovered that in human cells, EPHX1 mRNA and protein expression were regulated tissue-specificaly by the potent chemopreventive agent, sulforaphane. Subsequent mechanistic studies revealed that Nrf2/ARE pathway plays a central role in…

Subjects/Keywords: chemopreventive; Microsomal epoxide hydrolase; polymorphism

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yang, X. (2009). Human Microsomal Epoxide Hydrolase (EPHX1): Genetic Polymorphism And Regulation By Chemopreventive Agents. (Doctoral Dissertation). Penn State University. Retrieved from https://etda.libraries.psu.edu/catalog/9828

Chicago Manual of Style (16^th Edition):

Yang, Xi. “Human Microsomal Epoxide Hydrolase (EPHX1): Genetic Polymorphism And Regulation By Chemopreventive Agents.” 2009. Doctoral Dissertation, Penn State University. Accessed February 27, 2020. https://etda.libraries.psu.edu/catalog/9828.

MLA Handbook (7^th Edition):

Yang, Xi. “Human Microsomal Epoxide Hydrolase (EPHX1): Genetic Polymorphism And Regulation By Chemopreventive Agents.” 2009. Web. 27 Feb 2020.

Vancouver:

Yang X. Human Microsomal Epoxide Hydrolase (EPHX1): Genetic Polymorphism And Regulation By Chemopreventive Agents. [Internet] [Doctoral dissertation]. Penn State University; 2009. [cited 2020 Feb 27]. Available from: https://etda.libraries.psu.edu/catalog/9828.

Council of Science Editors:

Yang X. Human Microsomal Epoxide Hydrolase (EPHX1): Genetic Polymorphism And Regulation By Chemopreventive Agents. [Doctoral Dissertation]. Penn State University; 2009. Available from: https://etda.libraries.psu.edu/catalog/9828

University of Southern California

11. Wang, Jian. ABCB1 and IMPDH functional and genetic contributions to tacrolimus and mycophenolic acid therapy in transplant patients.

Degree: PhD, Molecular Pharmacology & Toxicology, 2009, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/535363/rec/458

► Tacrolimus and mycophenolic acid (MPA) are commonly used in clinic to prevent rejection in transplant recipients. The influence of ABCB1 polymorphisms on tacrolimus dosing has… (more)

▼ Tacrolimus and mycophenolic acid (MPA) are commonly used in clinic to prevent rejection in transplant recipients. The influence of ABCB1 polymorphisms on tacrolimus dosing has been questioned in previous studies with contradictory findings. Inosine 5'-monophosphate dehydrogenase (IMPDH), catalyzes the rate-limiting step of de novo pathway for purine synthesis, and is the major target of the immunosuppressive drug MPA. Variants in genes IMPDH may account for the interindividual variability in baseline enzyme activity, immunosuppressive efficacy and side effects in transplant recipients receiving MPA. In this study, three ABCB1 haplotypes CGC, TTT and CGT accounted for 44.1%, 40.7% and 7.6% of the total haplotypes, respectively in a total of 91 lung transplant patients. The tacrolimus [L/D] value in the CGC-CGC haplotype was significantly lower than in patients with CGC-TTT and TTT-TTT genotypes throughout the first post transplant year. As for IMPDH2, nine genetic variants were identified with frequencies of the rarer alleles ranging from 0.5 - 10.2%. A novel nonsynonymous variant L263F was identified, and the kinetic assay demonstrated that the IMPDH activity of L263F variant was decreased to 10% of the wild type. Seventeen genetic variants were identified in the IMPDH1 gene in our study, with frequencies of the rarer alleles ranging from 0.2 - 42.7%. Six tagging SNPs were selected to present two haplotype blocks in IMPDH1. No differences in the allele frequencies between ethnic groups were observed except SNP rs2288553. No significant associations were observed between each IMPDH1 SNP and incidence of leukopenia in MPA treated transplant patients. Two SNPs, rs2278293 and rs2278294, were significantly associated with the incidence of biopsy-proven acute rejection in the first year post transplantation. Both of these SNPs had positive and negative predictive values for acute rejection greater than 50%.; This study demonstrates that 1) analysis using the haplotypes derived from three common ABCB1 polymorphisms is predictive for tacrolimus dosing in lung transplant patients when eliminating the confounder CYP3A5 genotype; 2) IMPDH1 polymorphisms are associated with the incidence of biopsy-proven acute rejection in the first year post transplantation. Future studies of the multi-factorial nature of acute rejection should take into account IMPDH1 polymorphisms in MPA treated patients. Advisors/Committee Members: Burckart, Gilbert J. (Committee Chair), Beringer, Paul (Committee Member), Shen, Wei-chiang (Committee Member), Richmond, Frances J. (Committee Member), Watanabe, Richard M. (Committee Member).

Subjects/Keywords: pharmacogenetics; ABCB1; IMPDH; transplantation; polymorphism

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, J. (2009). ABCB1 and IMPDH functional and genetic contributions to tacrolimus and mycophenolic acid therapy in transplant patients. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/535363/rec/458

Chicago Manual of Style (16^th Edition):

Wang, Jian. “ABCB1 and IMPDH functional and genetic contributions to tacrolimus and mycophenolic acid therapy in transplant patients.” 2009. Doctoral Dissertation, University of Southern California. Accessed February 27, 2020. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/535363/rec/458.

MLA Handbook (7^th Edition):

Wang, Jian. “ABCB1 and IMPDH functional and genetic contributions to tacrolimus and mycophenolic acid therapy in transplant patients.” 2009. Web. 27 Feb 2020.

Vancouver:

Wang J. ABCB1 and IMPDH functional and genetic contributions to tacrolimus and mycophenolic acid therapy in transplant patients. [Internet] [Doctoral dissertation]. University of Southern California; 2009. [cited 2020 Feb 27]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/535363/rec/458.

Council of Science Editors:

Wang J. ABCB1 and IMPDH functional and genetic contributions to tacrolimus and mycophenolic acid therapy in transplant patients. [Doctoral Dissertation]. University of Southern California; 2009. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/535363/rec/458

Macquarie University

12. Junqueira Santiago, Marina. Regulation of the μ-opioid receptor signalling in naturally occurring variants and phosphorylation site mutants.

Degree: 2015, Macquarie University

URL: http://hdl.handle.net/1959.14/1068731

►

Empirical thesis.

Bibliography: pages 263-303.

1. General introduction and outline – 2. Introduction – 3. Experimental methodology – 4. Desensitisation and kinase modulators – 5.… (more)

▼

Empirical thesis.

Bibliography: pages 263-303.

1. General introduction and outline – 2. Introduction – 3. Experimental methodology – 4. Desensitisation and kinase modulators – 5. Regulation of N-terminal SNPs of hMOPr – 6. Regulation of TM1 and ICL2 SNPs of hMOPr – 7. The ICL3 : hMOPr SNPs and phosphosite mutants – 8. Regulation of C-terminal phosphosite mutant of hMOPr – 9. Summary and prospects.

Opioid drugs are highly effective for the treatment of moderate to severe nociceptive pain. They exert their analgesic and rewarding effects primarily by signalling through the μ-opioid receptor (MOPr). The focus of this project was to better understand MOPr signalling regulation by investigating natural variants of MOPr and MOPr phosphosite mutants.

Isogenic, stably transfected mouse pituitary adenoma (AtT20) cell lines expressing eight naturally occurring human MOPr variants and four phosphomutants were created. Opioid-stimulated changes in membrane potential were measured using a membrane potential-sensitive dye, while receptor phosphorylation of Ser 377 residue was determined by Western Blot and whole-cell ELISA was used to obtain the receptor surface loss dynamics.

The N-terminal MOPr variants, A6V and N40D, are the most common single-nucleotide polymorphisms found worldwide. Their signalling regulation was quite similar to the wild-type MOPr in each assay, where buprenorphine was the opiod with the most variance observed. In AtT20-hMOPr-L85I cells morphine mediated internalisation was not as substantial as previously reported, while the second intracellular loop (ICL2) polymorphism R181C dramatically impacted receptor ability to signal by affecting opioid affinity and probably G protein binding. The majority of the third intracellular loop (ICL3) variants had detrimental effect in receptor signalling and regulation which indicates the important role this region plays in G protein activation. In addition the multiple phosphorylation mutants also affected membrane expression which was related to endoplasmic reticulum sequestration and possible changes in receptor stability. Finally, deleting all the putative phosphorylation sites in the human MOPr C-terminal domain did not greatly influence homologous desensitisation of the membrane potential signal, yet completely abolished internalisation as expected. In contrast heterologous desensitisation was deeply compromised in some mutants of the ICL3 while total phosphorylation deletion of the C-terminal was the only variant to increase desensitisation of somatostatin signalling. Interestingly buprenorphine induced signalling had a quite different profile across the variants, and morphine and methodone signalling were more affected by the ICL3 changes when compared to opioid peptides and buprenorphine.

Overall, these results support the hypothesis of multiple mechanisms involved in regulation of MOPr, where ICL2 and ICL3 are crucial for G protein signalling, and receptor phosphorylation is not necessary for receptor desensitisation. In addition,…

Advisors/Committee Members: Macquarie University. Department of Biomedical Sciences.

Subjects/Keywords: Opioids – Receptors; opioid; polymorphism; desensitization

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Junqueira Santiago, M. (2015). Regulation of the μ-opioid receptor signalling in naturally occurring variants and phosphorylation site mutants. (Doctoral Dissertation). Macquarie University. Retrieved from http://hdl.handle.net/1959.14/1068731

Chicago Manual of Style (16^th Edition):

Junqueira Santiago, Marina. “Regulation of the μ-opioid receptor signalling in naturally occurring variants and phosphorylation site mutants.” 2015. Doctoral Dissertation, Macquarie University. Accessed February 27, 2020. http://hdl.handle.net/1959.14/1068731.

MLA Handbook (7^th Edition):

Junqueira Santiago, Marina. “Regulation of the μ-opioid receptor signalling in naturally occurring variants and phosphorylation site mutants.” 2015. Web. 27 Feb 2020.

Vancouver:

Junqueira Santiago M. Regulation of the μ-opioid receptor signalling in naturally occurring variants and phosphorylation site mutants. [Internet] [Doctoral dissertation]. Macquarie University; 2015. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/1959.14/1068731.

Council of Science Editors:

Junqueira Santiago M. Regulation of the μ-opioid receptor signalling in naturally occurring variants and phosphorylation site mutants. [Doctoral Dissertation]. Macquarie University; 2015. Available from: http://hdl.handle.net/1959.14/1068731

University of Manchester

13. Raginis-Zborowska, Alicja Iwona. Unravelling the genetic basis for cortical plasticity in the human swallowing motor system.

Degree: 2016, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306466

► Swallowing is an important physiological function leading to nourishment of the organism, controlled by complicated interactions between the muscles, the cranial nerves and multiple brain… (more)

▼ Swallowing is an important physiological function leading to nourishment of the organism, controlled by complicated interactions between the muscles, the cranial nerves and multiple brain structures. Swallowing impairments, also called dysphagia are a major health burden for patients with neurological diseases such as stroke, Parkinson’s disease as well as community dwelling elderly individuals. It has been shown that activation of undamaged swallowing motor cortex compensates for the initial lost swallowing function in stroke patients. Non-invasive brain stimulation provides a tool to explore excitability within the areas of the motor cortex responsible for swallowing muscles. Repetitive transcranial magnetic stimulation (rTMS) is one such technique, with defined frequency parameters, however the underlying reasons for the heterogeneity is responses to low (1Hz) and high (5Hz) frequencies is unclear. These physiological interactions affecting the neurological control of swallowing may be influenced by multiple genes and proteins. Insights into the molecular basis of swallowing through genetic interactions could provide a source of information which can be further used in understanding and treating swallowing impairments. Existing evidence is limited in terms of candidate proteins, genes and pathways which might drive the neural control of swallowing.The aim of my doctoral research was to explore genes which might be involved in swallowing neurophysiology and pathophysiology. My hypothesis is that swallowing due to its complicated physiology is most likely affected by multiple genes and interactions between genes and proteins.To study this hypothesis I used two experimentally distinct study designs. Firstly I explored a number of single nucleotide polymorphisms (SNPs) and potential candidate genes presented in the existing literature. Then, I performed a SNP- and gene-based Genome-Wide Association Study (GWAS) of self-reported swallowing impairments compared with over 500,000 single nucleotide changes. For GWAS I used a group of 555 community dwelling individuals from the Dyne Steel Cohort from the areas of Manchester and Newcastle. Further research involved replication of selected genes and SNPs from literature screening and GWAS using two rTMS paradigms on the largest to date cohort of healthy young volunteers. Forty one volunteers (were assessed for corticobulbar excitability after single-pulse TMS. Repeated measurements of motor evoked potentials from the pharynx and the hand were recorded after the interventions of 1Hz and 5Hz rTMS. The subjects’ individual responses were grouped according to multiple criteria and then associated with factors such as gender, ethnicity, time of day of the stimulation and individual genetic information.GWAS analysis for association with swallowing impairment identified one SNP rs17601696 which achieved genome-wide significance (P-value=5×10(-8)) within a non-coding region of chromosome 10. Gene-based analysis did not result in any genome-wide significant association. In… Advisors/Committee Members: OLLIER, WILLIAM WE, HAMDY, SHAHEEN S, Ollier, William, Pendleton, Neil, Hamdy, Shaheen.

Subjects/Keywords: swallowing; dysphagia; rTMS; polymorphism

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Raginis-Zborowska, A. I. (2016). Unravelling the genetic basis for cortical plasticity in the human swallowing motor system. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306466

Chicago Manual of Style (16^th Edition):

Raginis-Zborowska, Alicja Iwona. “Unravelling the genetic basis for cortical plasticity in the human swallowing motor system.” 2016. Doctoral Dissertation, University of Manchester. Accessed February 27, 2020. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306466.

MLA Handbook (7^th Edition):

Raginis-Zborowska, Alicja Iwona. “Unravelling the genetic basis for cortical plasticity in the human swallowing motor system.” 2016. Web. 27 Feb 2020.

Vancouver:

Raginis-Zborowska AI. Unravelling the genetic basis for cortical plasticity in the human swallowing motor system. [Internet] [Doctoral dissertation]. University of Manchester; 2016. [cited 2020 Feb 27]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306466.

Council of Science Editors:

Raginis-Zborowska AI. Unravelling the genetic basis for cortical plasticity in the human swallowing motor system. [Doctoral Dissertation]. University of Manchester; 2016. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306466

McGill University

14. Tsau, Josef Heng-Ko. Polymorphism and molecular motion in solid n-alkylammonium halides.

Degree: PhD, Department of Chemistry., 1970, McGill University

URL: http://digitool.library.mcgill.ca/thesisfile67688.pdf

Subjects/Keywords: Polymorphism (Crystallography)

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tsau, J. H. (1970). Polymorphism and molecular motion in solid n-alkylammonium halides. (Doctoral Dissertation). McGill University. Retrieved from http://digitool.library.mcgill.ca/thesisfile67688.pdf

Chicago Manual of Style (16^th Edition):

Tsau, Josef Heng-Ko. “Polymorphism and molecular motion in solid n-alkylammonium halides.” 1970. Doctoral Dissertation, McGill University. Accessed February 27, 2020. http://digitool.library.mcgill.ca/thesisfile67688.pdf.

MLA Handbook (7^th Edition):

Tsau, Josef Heng-Ko. “Polymorphism and molecular motion in solid n-alkylammonium halides.” 1970. Web. 27 Feb 2020.

Vancouver:

Tsau JH. Polymorphism and molecular motion in solid n-alkylammonium halides. [Internet] [Doctoral dissertation]. McGill University; 1970. [cited 2020 Feb 27]. Available from: http://digitool.library.mcgill.ca/thesisfile67688.pdf.

Council of Science Editors:

Tsau JH. Polymorphism and molecular motion in solid n-alkylammonium halides. [Doctoral Dissertation]. McGill University; 1970. Available from: http://digitool.library.mcgill.ca/thesisfile67688.pdf

Delft University of Technology

15. Wursten, N. Cooling crystallization under influence of a strong DC electric field:.

Degree: 2012, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:51ebd4ab-7816-49bf-85da-9395ec1bab3f

► Polymorphism is the ability of solid material to exist in more than one form or crystal structure. It is especially important for the pharmaceutical industry,… (more)

Subjects/Keywords: cooling crystallization; electric field; polymorphism

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wursten, N. (2012). Cooling crystallization under influence of a strong DC electric field:. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:51ebd4ab-7816-49bf-85da-9395ec1bab3f

Chicago Manual of Style (16^th Edition):

Wursten, N. “Cooling crystallization under influence of a strong DC electric field:.” 2012. Masters Thesis, Delft University of Technology. Accessed February 27, 2020. http://resolver.tudelft.nl/uuid:51ebd4ab-7816-49bf-85da-9395ec1bab3f.

MLA Handbook (7^th Edition):

Wursten, N. “Cooling crystallization under influence of a strong DC electric field:.” 2012. Web. 27 Feb 2020.

Vancouver:

Wursten N. Cooling crystallization under influence of a strong DC electric field:. [Internet] [Masters thesis]. Delft University of Technology; 2012. [cited 2020 Feb 27]. Available from: http://resolver.tudelft.nl/uuid:51ebd4ab-7816-49bf-85da-9395ec1bab3f.

Council of Science Editors:

Wursten N. Cooling crystallization under influence of a strong DC electric field:. [Masters Thesis]. Delft University of Technology; 2012. Available from: http://resolver.tudelft.nl/uuid:51ebd4ab-7816-49bf-85da-9395ec1bab3f

University of Tennessee – Knoxville

16. Peterson, Christopher Ryan. Color, Color Pattern, Habitat Use, and Morphology of Anolis conspersus.

Degree: MS, Ecology and Evolutionary Biology, 2016, University of Tennessee – Knoxville

URL: https://trace.tennessee.edu/utk_gradthes/4302

► Understanding color polymorphism and associated ecological and morphological divergence is important to improving out knowledge of diversity and speciation; anoles are a model clade… (more)

Subjects/Keywords: Anole; Bayesian statistics; color polymorphism

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Peterson, C. R. (2016). Color, Color Pattern, Habitat Use, and Morphology of Anolis conspersus. (Thesis). University of Tennessee – Knoxville. Retrieved from https://trace.tennessee.edu/utk_gradthes/4302

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Peterson, Christopher Ryan. “Color, Color Pattern, Habitat Use, and Morphology of Anolis conspersus.” 2016. Thesis, University of Tennessee – Knoxville. Accessed February 27, 2020. https://trace.tennessee.edu/utk_gradthes/4302.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Peterson, Christopher Ryan. “Color, Color Pattern, Habitat Use, and Morphology of Anolis conspersus.” 2016. Web. 27 Feb 2020.

Vancouver:

Peterson CR. Color, Color Pattern, Habitat Use, and Morphology of Anolis conspersus. [Internet] [Thesis]. University of Tennessee – Knoxville; 2016. [cited 2020 Feb 27]. Available from: https://trace.tennessee.edu/utk_gradthes/4302.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Peterson CR. Color, Color Pattern, Habitat Use, and Morphology of Anolis conspersus. [Thesis]. University of Tennessee – Knoxville; 2016. Available from: https://trace.tennessee.edu/utk_gradthes/4302

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

17. Verschuur, M. Functional aspects of fibrinogen B and plasminogen activator inhibitor-1 promoter variants.

Degree: 2005, Dept. of Hematology, Leiden University Medical Center, Leiden University

URL: http://hdl.handle.net/1887/615

Subjects/Keywords: Fibrinogen; Polymorphism

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Verschuur, M. (2005). Functional aspects of fibrinogen B and plasminogen activator inhibitor-1 promoter variants. (Doctoral Dissertation). Dept. of Hematology, Leiden University Medical Center, Leiden University. Retrieved from http://hdl.handle.net/1887/615

Chicago Manual of Style (16^th Edition):

Verschuur, M. “Functional aspects of fibrinogen B and plasminogen activator inhibitor-1 promoter variants.” 2005. Doctoral Dissertation, Dept. of Hematology, Leiden University Medical Center, Leiden University. Accessed February 27, 2020. http://hdl.handle.net/1887/615.

MLA Handbook (7^th Edition):

Verschuur, M. “Functional aspects of fibrinogen B and plasminogen activator inhibitor-1 promoter variants.” 2005. Web. 27 Feb 2020.

Vancouver:

Verschuur M. Functional aspects of fibrinogen B and plasminogen activator inhibitor-1 promoter variants. [Internet] [Doctoral dissertation]. Dept. of Hematology, Leiden University Medical Center, Leiden University; 2005. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/1887/615.

Council of Science Editors:

Verschuur M. Functional aspects of fibrinogen B and plasminogen activator inhibitor-1 promoter variants. [Doctoral Dissertation]. Dept. of Hematology, Leiden University Medical Center, Leiden University; 2005. Available from: http://hdl.handle.net/1887/615

Brigham Young University

18. Perry, Cynthia Elizabeth. Association Between Polymorphisms Associated with Major Depression, Cognitive Function, and Stress Regulation and Telomere Length in Older Community-Dwelling Adults and in Older Competitive Athletes.

Degree: MS, 2016, Brigham Young University

URL: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7214&context=etd

► Many factors detrimental to healthy aging have been proposed including depression, stress, cognitive decline, and telomere shortening. Of specific interest are the genetic factors that… (more)

▼ Many factors detrimental to healthy aging have been proposed including depression, stress, cognitive decline, and telomere shortening. Of specific interest are the genetic factors that may contribute to these factors and subsequently lead to accelerated telomere shortening and aging, namely the Bcl1, 5-HT, DRD2, and ApoE polymorphisms. We sought to: 1) further clarify the role of depression, stress tolerance, and cognitive decline in aging by examining the effect of associated polymorphisms (Bcl1, 5-HT, DRD2, and ApoE) on telomere length in two samples of older adults and 2) determine the difference in absolute telomere length between the two groups. We examined two samples of older adults: participants in a competitive, athletic event (N=220; mean age=66.8 years) and a sample of community-dwelling older adults (N=208; mean age=69.1 years). Participants completed a questionnaire with demographic information and provided a saliva sample. The Bcl1, 5-HT, DRD2, and ApoE polymorphisms were determined using PCR and Taqman assays. Telomere length was determined using qPCR analysis. The community-dwelling group had significantly shorter telomere lengths than the athletic group (t=-4.82, p< .0001). Additionally, for males in the athletic group, the L/S genotype of the 5-HT polymorphism was associated with longer telomere length. In males in the community-dwelling group, the GC genotype of the Bcl1 polymorphism was associated with shorter telomere length. In females in the athletic group, the GC and GG genotypes of the Bcl1 polymorphism were associated with shorter telomere length with the opposite being true for females in the community-dwelling group: the GC genotype of the Bcl1 polymorphism predicted longer telomere length. Exercising nearly everyday and the length of exercise were associated with telomere length in both groups. Our results indicate that competitive athletic activity in older age is associated with increased telomere length, longer periods of exercise at one time may contribute to longer telomere length, and the Bcl1 and 5-HT polymorphisms are associated with telomere length in older adults.

Subjects/Keywords: Telomeres; healthy aging; Bcl1 polymorphism; 5-HT polymorphism; exercise; Psychology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Perry, C. E. (2016). Association Between Polymorphisms Associated with Major Depression, Cognitive Function, and Stress Regulation and Telomere Length in Older Community-Dwelling Adults and in Older Competitive Athletes. (Masters Thesis). Brigham Young University. Retrieved from https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7214&context=etd

Chicago Manual of Style (16^th Edition):

Perry, Cynthia Elizabeth. “Association Between Polymorphisms Associated with Major Depression, Cognitive Function, and Stress Regulation and Telomere Length in Older Community-Dwelling Adults and in Older Competitive Athletes.” 2016. Masters Thesis, Brigham Young University. Accessed February 27, 2020. https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7214&context=etd.

MLA Handbook (7^th Edition):

Perry, Cynthia Elizabeth. “Association Between Polymorphisms Associated with Major Depression, Cognitive Function, and Stress Regulation and Telomere Length in Older Community-Dwelling Adults and in Older Competitive Athletes.” 2016. Web. 27 Feb 2020.

Vancouver:

Perry CE. Association Between Polymorphisms Associated with Major Depression, Cognitive Function, and Stress Regulation and Telomere Length in Older Community-Dwelling Adults and in Older Competitive Athletes. [Internet] [Masters thesis]. Brigham Young University; 2016. [cited 2020 Feb 27]. Available from: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7214&context=etd.

Council of Science Editors:

Perry CE. Association Between Polymorphisms Associated with Major Depression, Cognitive Function, and Stress Regulation and Telomere Length in Older Community-Dwelling Adults and in Older Competitive Athletes. [Masters Thesis]. Brigham Young University; 2016. Available from: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7214&context=etd

Univerzitet u Beogradu

19. Pantelić, Jelica R., 1970-. Ispitivanje polimorfizama eNOS gena kao faktora rizika za razvoj retinopatije prevremeno rođene dece.

Degree: Medicinski fakultet, 2017, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:14296/bdef:Content/get

►

Oftalmologija - humana genetika / ophthalmology - human genetics

Uvod: Retinopatija prematuriteta (ROP) je oboljenje mrežnjače oka prevremeno roñene dece i osnovni je uzrok teškog… (more)

▼

Oftalmologija - humana genetika / ophthalmology - human genetics

Uvod: Retinopatija prematuriteta (ROP) je oboljenje mrežnjače oka prevremeno roñene dece i osnovni je uzrok teškog oštenja vida u detinjstvu. Genetička istraživanja ROP usmerena su ka otkrivanju varijanti gena odgovornih za razvoj teških formi ROP-a. Cilj ove studije bio je da ispita učestalost genotipova i alela polimorfizama T-786C i 4a/4b gena za endotelnu azot oksid sintetazu (eNOS) u populaciji prevremeno roñene dece kao i povezanost ispitivanih polimorfnih varijanti sa nastankom teškog stepena retinopatije. Takoñe, cilj ove studije je ispitivanje kliničkih faktora rizika udruženih sa nastankom teškog stepena ROP-a. Metodologija: Istraživanje je uključilo 239 prevremeno roñene dece. Na osnovu sprovedenog oftalmološkog skrininga prevremeno roñena deca su podeljena u dve grupe. ROP grupa je obuhvatila 113 dece kod kojih je stepen ROP-a zahtevao oftalmološku terapiju, a kontrolnu grupu činilo je 126 dece bez terapije. DNK je izolovana iz brisa bukalne sluznice prevremeno roñene dece a ispitivanje polimorfizama vršeno je PCR metodom. Rezultati: Ispitivanje polimorfizma T-786C pokazalo je da je 39,1% dece homozigotno za češći alel T (genotip TT), 52,3% su heterozigoti (genotip CT) i 8,6% homozigoti za reñi alel C (genotip CC). Učestalost C alela je 34,8%. Učestalost genotipova T-786C polimorfizma u grupi sa ROP-om je: 40,0% TT genotipa, 51,7% CT genotipa i CC genotipa 8,3%. U kontrolnoj grupi učestalost TT genotipa je 38,2%, CT genotipa 52,9% i CC genotipa 8,8%. Učestalost C alela u ROP grupi je 34,2%, a 35,3% u kontrolnoj grupi. Ispitivanjem polimorfizma 4a/4b utvrñeno je da je 65,3% dece homozigotno za češći alel 4b (genotip bb), 31,2% su heterozigoti (genotip ab) i 3,5% homozigoti za reñi alel 4a (genotip aa). Učestalost 4a alela je 19,1%. Učestalost 4a/4b polimorfizma u grupi sa ROP-om je: genotipa 4bb 60,2%, genotipa 4ba 34,9% i 4aa genotipa 4,9%. U kontrolnoj grupi učestalost genotipa 4bb je 70,1%, genotipa 4ba 27,6% i 4aa genotipa 2,3%. Učestalost 4a alela u ROP grupi je 22,3%, a 16,1% u kontrolnoj grupi...

Advisors/Committee Members: Stefanović, Ivan, 1964-.

Subjects/Keywords: Retinopathy of prematurity; T-786C polymorphism; 4a/b polymorphism; eNOS gene

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pantelić, Jelica R., 1. (2017). Ispitivanje polimorfizama eNOS gena kao faktora rizika za razvoj retinopatije prevremeno rođene dece. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:14296/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pantelić, Jelica R., 1970-. “Ispitivanje polimorfizama eNOS gena kao faktora rizika za razvoj retinopatije prevremeno rođene dece.” 2017. Thesis, Univerzitet u Beogradu. Accessed February 27, 2020. https://fedorabg.bg.ac.rs/fedora/get/o:14296/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pantelić, Jelica R., 1970-. “Ispitivanje polimorfizama eNOS gena kao faktora rizika za razvoj retinopatije prevremeno rođene dece.” 2017. Web. 27 Feb 2020.

Vancouver:

Pantelić, Jelica R. 1. Ispitivanje polimorfizama eNOS gena kao faktora rizika za razvoj retinopatije prevremeno rođene dece. [Internet] [Thesis]. Univerzitet u Beogradu; 2017. [cited 2020 Feb 27]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:14296/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pantelić, Jelica R. 1. Ispitivanje polimorfizama eNOS gena kao faktora rizika za razvoj retinopatije prevremeno rođene dece. [Thesis]. Univerzitet u Beogradu; 2017. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:14296/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. Shepherd, Jimmie G. Crystalline Polymorphism of Nitrates.

Degree: 1951, North Texas State College

URL: https://digital.library.unt.edu/ark:/67531/metadc97053/

► The purpose of this study was to investigate the polymorphism of a group of related compounds. Special emphasis was placed upon the temperature at which… (more)

Subjects/Keywords: crystalline polymorphism; Polymorphism (Crystallography); Nitrates.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shepherd, J. G. (1951). Crystalline Polymorphism of Nitrates. (Thesis). North Texas State College. Retrieved from https://digital.library.unt.edu/ark:/67531/metadc97053/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shepherd, Jimmie G. “Crystalline Polymorphism of Nitrates.” 1951. Thesis, North Texas State College. Accessed February 27, 2020. https://digital.library.unt.edu/ark:/67531/metadc97053/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shepherd, Jimmie G. “Crystalline Polymorphism of Nitrates.” 1951. Web. 27 Feb 2020.

Vancouver:

Shepherd JG. Crystalline Polymorphism of Nitrates. [Internet] [Thesis]. North Texas State College; 1951. [cited 2020 Feb 27]. Available from: https://digital.library.unt.edu/ark:/67531/metadc97053/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shepherd JG. Crystalline Polymorphism of Nitrates. [Thesis]. North Texas State College; 1951. Available from: https://digital.library.unt.edu/ark:/67531/metadc97053/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Univerzitet u Beogradu

21. Varljen, Tatjana, 1973- 30806375. Ispitivanje učestalosti polimorfizama gena za faktor nekroze tumora [alfa], interleukin 6 i interleukin 1[beta] kod prevremeno rođene dece kao faktor rizika za nastanak sepse.

Degree: Medicinski fakultet, 2019, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:20534/bdef:Content/get

►

Medicina - Molekularna medicina / Medicine - Molecular medicine

Neonatalna sepsa predstavlja vodeći uzrok morbiditeta i mortaliteta kod prevremeno rođene dece. Genetički faktori mogu uticati… (more)

▼

Medicina - Molekularna medicina / Medicine - Molecular medicine

Neonatalna sepsa predstavlja vodeći uzrok morbiditeta i mortaliteta kod prevremeno rođene dece. Genetički faktori mogu uticati na nastanak, tok i ishod rane neonatalne sepse. Cilj našeg istraživanja bio je da ispitamo povezanost TNFα -308 G/A, IL6 -174 G/C i IL1β -511 G/A polimorfizama sa nastankom i ishodom rane neonatalne sepse kod prematurusa. Istraživanje je obuhvatilo 471 prevremeno rođeno dete, 282 sa sepsom (151 hemokulturom potvrđenom i 131 kliničkom sepsom) i 189 bez sepse koji su činili kontrolnu grupu. Učestalost alela A i AA genotipa TNFα -308 G/A polimorfizma je statistički značajno veća kod prematurusa sa sepsom u odnosu na prematuruse kontrolne grupe. GA+AA genotipovi polimorfizma TNFα -308 G/A su statistički značajno povezani sa nastankom hemokulturom potvrđene sepse i kliničke sepse. Učestalost AA genotipa IL1β -511 G/A polimorfizma statistički je značajno veća u grupi prematurusa sa hemokulturom potvrđenom sepsom i kliničkom sepsom u odnosu na kontrolnu grupu. Takođe, AA genotip IL1β -511 G/A polimorfizma udružen je sa letalnim ishodom od sepse kod prematurusa. Logistička regresiona analiza sa gestacijskom starošću, porođajnom telesnom masom i Apgar skorom u ’5 kao kovarijatama potvrdila je statistički značajnu povezanost geneotipova GA+AA TNFα -308 G/A i AA IL1β -511 G/A polimorfizma sa nastankom sepse. U našoj studiji nema statistički značajne razlike u učestalosti alela i genotipova IL6 -174 G/C polimorfizma između grupa prematurusa sa hemokulturom potvrđenom, kliničkom sepsom i kontrolne grupe prematurusa. Rezultati naše studije pokazuju da su alel A i AA genotip TNFα -308 G/A i AA genotip IL1β -511 G/A polimorfizma faktori rizika za razvoj rane neonatalne sepse. Genotip AA IL1β -511 G/A polimorfizma je faktor rizika za smrtni ishod od rane neonatalne sepse prematurusa.

Advisors/Committee Members: Damjanović, Tatjana, 1964- 29979751.

Subjects/Keywords: TNFα -308 G/A polymorphism; IL6 -174 G/C polymorphism; IL1β -511 G/A polymorphism; early onset sepsis; lethal outcome

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Varljen, Tatjana, 1. 3. (2019). Ispitivanje učestalosti polimorfizama gena za faktor nekroze tumora [alfa], interleukin 6 i interleukin 1[beta] kod prevremeno rođene dece kao faktor rizika za nastanak sepse. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:20534/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Varljen, Tatjana, 1973- 30806375. “Ispitivanje učestalosti polimorfizama gena za faktor nekroze tumora [alfa], interleukin 6 i interleukin 1[beta] kod prevremeno rođene dece kao faktor rizika za nastanak sepse.” 2019. Thesis, Univerzitet u Beogradu. Accessed February 27, 2020. https://fedorabg.bg.ac.rs/fedora/get/o:20534/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Varljen, Tatjana, 1973- 30806375. “Ispitivanje učestalosti polimorfizama gena za faktor nekroze tumora [alfa], interleukin 6 i interleukin 1[beta] kod prevremeno rođene dece kao faktor rizika za nastanak sepse.” 2019. Web. 27 Feb 2020.

Vancouver:

Varljen, Tatjana 13. Ispitivanje učestalosti polimorfizama gena za faktor nekroze tumora [alfa], interleukin 6 i interleukin 1[beta] kod prevremeno rođene dece kao faktor rizika za nastanak sepse. [Internet] [Thesis]. Univerzitet u Beogradu; 2019. [cited 2020 Feb 27]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:20534/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Varljen, Tatjana 13. Ispitivanje učestalosti polimorfizama gena za faktor nekroze tumora [alfa], interleukin 6 i interleukin 1[beta] kod prevremeno rođene dece kao faktor rizika za nastanak sepse. [Thesis]. Univerzitet u Beogradu; 2019. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:20534/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

North-West University

22. Mbongwa, Hlengiwe Prosperity. Characterisation of the SULT1A1 polymorphism in a South African Tswana population group / y Hlengiwe P. Mbongwa.

Degree: 2010, North-West University

URL: http://hdl.handle.net/10394/4225

► This dissertation brings to the fore the “Characterization of the SULT1A1 polymorphism in a South Africa Tswana population group.” The primary experimental group studied came… (more)

▼ This dissertation brings to the fore the “Characterization of the SULT1A1 polymorphism in a South Africa Tswana population group.” The primary experimental group studied came from South African homogeneous Tswana individuals who participated voluntarily in an ongoing large-scale epidemiological Prospective Urban and Rural Epidemiological (PURE) study the North-West University (Potchefstroom Campus) participates in, as one of the 16 low- middleand high-income countries across the world. The primary aspect investigated was the comprehensive profile of the single nucleotide polymorphism (SNP) and copy number variation (CNP) of the SULT1A1 gene. Using the PCRbased RFLP method, SULT1A1 genotypes, and allele frequency distributions in an experimental group of 1 867 individuals were determined. According to the literature this is by far the largest and most homogeneous group from which such information has been acquired to date. The SULT1A1*1, SULT1A1*1/*2 and SULT1A1*2 genotypes were found to be present at a percentage of 43.76, 47.12 and 9.11 respectively. In comparison to similar studies in other population groups, results from this study indicate that there are ethnic differences in the SULT1A1 genotypes incidence. Asian group differs from Caucasian and Tswana groups because of its exceptionally high prevalence of individuals with the SULT1A1*1 genotype and a very low incidence of the SULT1A1*2 genotype. The SULT1A1*1 genotype profiles of Caucasian and Tswana groups were comparable, but notable differences were observed for the SULT1A1*2 genotype. Using a quantitative multiplex PCR method for the CNV study, the numbers of copies of the SULT1A1 gene in the Tswana population were determined, and the results showed 1 to ~5 copies: only 0.65% of the subjects had a single copy, whereas 59.69% of the subjects had 3 or more copies. This result shows a significant discrepancy between the Caucasian-American samples, which showed that only 26% from that group had more than three copies. However, there is a significant relationship with the African-American population, which presented 63% with 3 or more copies. This finding confirms results from a much smaller African-American study, and suggests a possible genetic link between the African Tswana and the heritage of the African-Americans. These findings were submitted for publication to the South African Journal of Science, as that journal specializes in publication of new knowledge that has a regional focus on Africa. Simultaneous phenotypic consequences of the SNP and CNP of the SULT1A1 gene, as well as the thermo-stable and thermo-labile forms of the sulfotransferases were determined. For this, the formation of [35S]-4-nitrophenyl sulphate from 4-nitrophenol and [35S]-3’-phosphoadenosine- 5’-phosphosulfate ([35S]-PAPS) in platelet homogenates were measured, with the data normalized to a common platelet count. This investigation required fresh blood for enzyme activity. These samples came from 98 Caucasian subjects who voluntarily participated in this part of the study. The…

Subjects/Keywords: PURE study; South African Tswana population; Copy number polymorphism; Single nucleotide polymorphism; SULT1A1 polymorphism; Sulfotransferases; Targeted metabolomics

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mbongwa, H. P. (2010). Characterisation of the SULT1A1 polymorphism in a South African Tswana population group / y Hlengiwe P. Mbongwa. (Thesis). North-West University. Retrieved from http://hdl.handle.net/10394/4225

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mbongwa, Hlengiwe Prosperity. “Characterisation of the SULT1A1 polymorphism in a South African Tswana population group / y Hlengiwe P. Mbongwa. ” 2010. Thesis, North-West University. Accessed February 27, 2020. http://hdl.handle.net/10394/4225.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mbongwa, Hlengiwe Prosperity. “Characterisation of the SULT1A1 polymorphism in a South African Tswana population group / y Hlengiwe P. Mbongwa. ” 2010. Web. 27 Feb 2020.

Vancouver:

Mbongwa HP. Characterisation of the SULT1A1 polymorphism in a South African Tswana population group / y Hlengiwe P. Mbongwa. [Internet] [Thesis]. North-West University; 2010. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/10394/4225.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mbongwa HP. Characterisation of the SULT1A1 polymorphism in a South African Tswana population group / y Hlengiwe P. Mbongwa. [Thesis]. North-West University; 2010. Available from: http://hdl.handle.net/10394/4225

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Bradford

23. Kulkarni, Chaitrali S. Novel formulations of a poorly soluble drug using the extrusion process.

Degree: PhD, 2013, University of Bradford

URL: http://hdl.handle.net/10454/7334

► Hot melt extrusion has attracted recent interest from the pharmaceutical industry and academia as an innovative drug delivery technology. This novel technique has been shown… (more)

▼ Hot melt extrusion has attracted recent interest from the pharmaceutical industry and academia as an innovative drug delivery technology. This novel technique has been shown to be a viable and robust method for preparing different drug delivery systems including pellets, implants, tablets, capsules and granules. The aim of this research was to understand hot melt extrusion processing and explore its pharmaceutical applications. Two applications of hot melt extrusion (HME) have been investigated to improve the properties of poorly soluble thermolabile drugs; polymeric solid dispersions and solid state polymorphic transformation. HME is a solvent free, continuous and readily scalable technique which is increasingly being considered as a viable alternative to conventionally used batch techniques. However, the high temperature and shear forces imparted by the extrusion process can limit its applications with heat sensitive active pharmaceutical ingredients (APIs). Artemisinin was selected as a model drug which being thermolabile in nature and possesses processing challenges to processing HME. A low Tg amphiphillic copolymer, Soluplus® was selected as a matrix material. Drug-polymer compatibility was studied using rotational rheometry and thermal characterisation. The drug was found to be completely dissolved within the polymer, although some discolouration of the mixture was observed, indicating degradation of the API. The addition of a small percentage of citric acid to the formulation was found to prevent this degradation by increasing the pH. The dissolution profile of the formulation was approximately five times higher compared to that of the pure drug. The pharmacokinetic study was carried out using Albino rats to calculate bioavailability. The area under plasma concentration time curve (AUC0-24hr) and peak plasma concentration (Cmax) were four times higher for the prepared solid dispersion compared to that of pure artemisinin. Extruded solid dispersions were found to be amorphous in nature and maintained stability for 2 years. A second route to improving the solubility of poorly soluble APIs was also investigated. It was found that under carefully controlled conditions, high temperature extrusion (HTE) could be used to achieve polymorphic transformation with a number of APIs. This solvent-free continuous process was demonstrated with artemisinin, piracetam, carbamazepine and chlorpropamide. Artemisinin was used as a detailed case study of stability, solvent mediated transformation and mechanism of polymrophic transformation during extrusion, using computational modelling and model shear flows. At high temperature, phase transformation from orthorhombic to triclinic crystals was found to occur via the vapour phase. Under mechanical stress the crystalline structure was disrupted, leading to new surfaces being continuously formed and exposed to high temperatures; thus accelerating the transformation process. Polymorphic transformation during HTE was found to comprise three stages; i) preheating and conveying; ii)…

Subjects/Keywords: HME; Thermolabile drug: Artemisinin; Soluplus®; Polymorphism; Stability.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kulkarni, C. S. (2013). Novel formulations of a poorly soluble drug using the extrusion process. (Doctoral Dissertation). University of Bradford. Retrieved from http://hdl.handle.net/10454/7334

Chicago Manual of Style (16^th Edition):

Kulkarni, Chaitrali S. “Novel formulations of a poorly soluble drug using the extrusion process.” 2013. Doctoral Dissertation, University of Bradford. Accessed February 27, 2020. http://hdl.handle.net/10454/7334.

MLA Handbook (7^th Edition):

Kulkarni, Chaitrali S. “Novel formulations of a poorly soluble drug using the extrusion process.” 2013. Web. 27 Feb 2020.

Vancouver:

Kulkarni CS. Novel formulations of a poorly soluble drug using the extrusion process. [Internet] [Doctoral dissertation]. University of Bradford; 2013. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/10454/7334.

Council of Science Editors:

Kulkarni CS. Novel formulations of a poorly soluble drug using the extrusion process. [Doctoral Dissertation]. University of Bradford; 2013. Available from: http://hdl.handle.net/10454/7334

Dalhousie University

24. Holland, Patrick. DRUGS, DIMERS, AND MUTATIONS: INVESTIGATING THE EFFECTS OF LIGANDS AND A ?2-ADRENERGIC POLYMORPHISM ON HOMO/HETERODIMERIZATION OF ?2-ADRENERGIC AND ANGIOTENSIN II TYPE 1 RECEPTORS.

Degree: MS, Department of Pharmacology, 2012, Dalhousie University

URL: http://hdl.handle.net/10222/15245

► GPCRs are known to form dimeric structures, and this affects their pharmacological properties. The ?2AR and AT1aR are GPCRs that are involved the regulation of… (more)

Subjects/Keywords: GPCRs; Signalling; Polymorphism; Dimerization; Receptor Pharmacology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Holland, P. (2012). DRUGS, DIMERS, AND MUTATIONS: INVESTIGATING THE EFFECTS OF LIGANDS AND A ?2-ADRENERGIC POLYMORPHISM ON HOMO/HETERODIMERIZATION OF ?2-ADRENERGIC AND ANGIOTENSIN II TYPE 1 RECEPTORS. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/15245

Chicago Manual of Style (16^th Edition):

Holland, Patrick. “DRUGS, DIMERS, AND MUTATIONS: INVESTIGATING THE EFFECTS OF LIGANDS AND A ?2-ADRENERGIC POLYMORPHISM ON HOMO/HETERODIMERIZATION OF ?2-ADRENERGIC AND ANGIOTENSIN II TYPE 1 RECEPTORS.” 2012. Masters Thesis, Dalhousie University. Accessed February 27, 2020. http://hdl.handle.net/10222/15245.

MLA Handbook (7^th Edition):

Holland, Patrick. “DRUGS, DIMERS, AND MUTATIONS: INVESTIGATING THE EFFECTS OF LIGANDS AND A ?2-ADRENERGIC POLYMORPHISM ON HOMO/HETERODIMERIZATION OF ?2-ADRENERGIC AND ANGIOTENSIN II TYPE 1 RECEPTORS.” 2012. Web. 27 Feb 2020.

Vancouver:

Holland P. DRUGS, DIMERS, AND MUTATIONS: INVESTIGATING THE EFFECTS OF LIGANDS AND A ?2-ADRENERGIC POLYMORPHISM ON HOMO/HETERODIMERIZATION OF ?2-ADRENERGIC AND ANGIOTENSIN II TYPE 1 RECEPTORS. [Internet] [Masters thesis]. Dalhousie University; 2012. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/10222/15245.

Council of Science Editors:

Holland P. DRUGS, DIMERS, AND MUTATIONS: INVESTIGATING THE EFFECTS OF LIGANDS AND A ?2-ADRENERGIC POLYMORPHISM ON HOMO/HETERODIMERIZATION OF ?2-ADRENERGIC AND ANGIOTENSIN II TYPE 1 RECEPTORS. [Masters Thesis]. Dalhousie University; 2012. Available from: http://hdl.handle.net/10222/15245

25. 손, 진경. Significant Association of IL-18 Genetic Polymorphisms with Aspirin-Intolerant Urticaria in a Korean Population.

Degree: 2010, Ajou University

URL: http://repository.ajou.ac.kr/handle/201003/2270 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010940

►

"Introduction : Aspirin(acetylsalicylic acid)-intolerant urticaria(AIU) aggravates urticaria after aspirin ingestion. Although the pathogenesis of AIU has not been fully understood, mast cell activation and neutrophil… (more)

▼

"Introduction : Aspirin(acetylsalicylic acid)-intolerant urticaria(AIU) aggravates urticaria after aspirin ingestion. Although the pathogenesis of AIU has not been fully understood, mast cell activation and neutrophil infiltration have been suggested to be involved. Interleukin-18 (IL-18) can stimulate mast cells and then release inflammatory mediators such as IL-4, IL-13 by stimulating mast cells. IL-18 activates neutrophils by inducing the production of TNFα, which in turn induces the synthesis of leukotriene B4. The aim of this study is to elucidate the genetic contribution of the IL-18 gene on the phathogenesis of AIU. Materials and Methods : To perform genetic association study of IL-18 gene polymorphism with AIU, 247 patients with aspirin-intolerant urticaria (AIU) and 196 normal healthy controls(NC) were recruited from Ajou University Hospital. Two promoter polymorphisms of IL-18 gene at -607A>C and -137G>C were genotyped using a primer extension method. The functional effects of the genetic polymorphims of IL-18 were examined by luciferase reporter assay, electrophoretic mobility shift assay (EMSA) and neutrophil chemotactic assay. Results : The minor allele frequency of IL-18 at -607 A>C and haplotype 1 [C-607G-137] showed significantly higher in AIAU than in NC groups(p=0.019, for AIAU vs NC; p=0.048, for AIU vs NC). The promoter-reporter construct carrying the HT1 [CG] displayed significantly higher luciferase activity than those with other haplotypes, HT2 [AG] or HT3 [AC] in two different cells including HMC-1 and Beas2B. EMSA finding showed that CREB2 bound more tightly to the -607C allele sequence than to the A allele sequence by EMSA. Moreover, subjects significantly increased neutrophil chemotaxis carrying -607C allele (p<0.001). Conclusion : Our findings suggest that the promoter polymorphism of IL-18 modulates IL-18 expression by altering the binding affinities of transcription factor and increasing neutrophil chemotaxis, finally contribute to the susceptibility of AIU. Key words Interleukin-18, mast cell, neutrophil, aspirin, urticaria, genetic polymorphism "

"연구배경 및 목적 : 아스피린 과민성 두드러기(aspirin-intolerant urticaria, AIU) 는 아스피린의 복용 후, 두드러기 증상의 악화를 초래한다. 아스피린 과민성 두드러기의 병인기전은 명확하게 밝혀지지 않았지만, 비만세포의 탈 과립화와 호중구의 침윤이 관여하는 것으로 보고되었다. 인터류킨-18(IL-18)은 비만세포를 자극하여 인터류킨-4와 인터류킨-13과 같은 염증신호전달 물질들을 유리시키고, 류코트리엔B4의 합성을 유도하여 종양 괴사 인자α (Tumor necrosis factor α, TNFα) 와 같은 사이토카인을 분비시켜 호중구의 활성에 주요한 역할을 나타낸다. 본 연구는 아스피린 과민성 두드러기에 대한 IL-18유전자의 유전적 관련성 여부를 연구하였다. 재료 및 방법 : 아주대 병원에 내원한 아스피린 과민성 급성 두드러기(aspirin-intolerant acute urticaria, AIAU)01 환자 130명, 아스피린 과민성 만성 두드러기(aspirin-intolerant chronic urticaria, AICU) 환자145명, 정상 대조군(normal healthy control, NC) 196명의 한국인을 대상으로, IL-18 유전자의 단일염기 다형성(single nucleotide polymorphism, SNP)에 따른 유전자 연관성 연구를 수행하였다. IL-18 유전자 전사조절 부위의 -607 A>C와 -137G>C 의 다형성에 따른 기능 차이를 규명하기 위해 luciferase reporter assay와 전기 이동성 교대 분석 실험(electrophoretic mobility shift assay, EMSA)을 수행하였으며, 정상…

Advisors/Committee Members: 200824662, 손, 진경.

Subjects/Keywords: IL-18; aspirin intolerant urticaria; polymorphism

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

손, �. (2010). Significant Association of IL-18 Genetic Polymorphisms with Aspirin-Intolerant Urticaria in a Korean Population. (Thesis). Ajou University. Retrieved from http://repository.ajou.ac.kr/handle/201003/2270 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010940

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

손, 진경. “Significant Association of IL-18 Genetic Polymorphisms with Aspirin-Intolerant Urticaria in a Korean Population.” 2010. Thesis, Ajou University. Accessed February 27, 2020. http://repository.ajou.ac.kr/handle/201003/2270 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010940.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

손, 진경. “Significant Association of IL-18 Genetic Polymorphisms with Aspirin-Intolerant Urticaria in a Korean Population.” 2010. Web. 27 Feb 2020.

Vancouver:

손 �. Significant Association of IL-18 Genetic Polymorphisms with Aspirin-Intolerant Urticaria in a Korean Population. [Internet] [Thesis]. Ajou University; 2010. [cited 2020 Feb 27]. Available from: http://repository.ajou.ac.kr/handle/201003/2270 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010940.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

손 �. Significant Association of IL-18 Genetic Polymorphisms with Aspirin-Intolerant Urticaria in a Korean Population. [Thesis]. Ajou University; 2010. Available from: http://repository.ajou.ac.kr/handle/201003/2270 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010940

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Loughborough University

26. Simone, Elena. Application of process analytical technology (PAT) tools for the better understanding and control of the crystallization of polymorphic and impure systems.

Degree: PhD, 2015, Loughborough University

URL: https://dspace.lboro.ac.uk/2134/20098 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.679944

► This work presents a comprehensive study on the application of PAT tools to study, monitor and control polymorphism during batch cooling crystallization processes. For the… (more)

Subjects/Keywords: 660; Crystallization; Polymorphism; PAT tools; Raman spectroscopy

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Simone, E. (2015). Application of process analytical technology (PAT) tools for the better understanding and control of the crystallization of polymorphic and impure systems. (Doctoral Dissertation). Loughborough University. Retrieved from https://dspace.lboro.ac.uk/2134/20098 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.679944

Chicago Manual of Style (16^th Edition):

Simone, Elena. “Application of process analytical technology (PAT) tools for the better understanding and control of the crystallization of polymorphic and impure systems.” 2015. Doctoral Dissertation, Loughborough University. Accessed February 27, 2020. https://dspace.lboro.ac.uk/2134/20098 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.679944.

MLA Handbook (7^th Edition):

Simone, Elena. “Application of process analytical technology (PAT) tools for the better understanding and control of the crystallization of polymorphic and impure systems.” 2015. Web. 27 Feb 2020.

Vancouver:

Simone E. Application of process analytical technology (PAT) tools for the better understanding and control of the crystallization of polymorphic and impure systems. [Internet] [Doctoral dissertation]. Loughborough University; 2015. [cited 2020 Feb 27]. Available from: https://dspace.lboro.ac.uk/2134/20098 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.679944.

Council of Science Editors:

Simone E. Application of process analytical technology (PAT) tools for the better understanding and control of the crystallization of polymorphic and impure systems. [Doctoral Dissertation]. Loughborough University; 2015. Available from: https://dspace.lboro.ac.uk/2134/20098 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.679944

University of Louisville

27. Buscaglia, Robert. The dynamic equilibrium of human telomeric G-quadruplexes.

Degree: PhD, 2012, University of Louisville

URL: 10.18297/etd/186 ; https://ir.library.louisville.edu/etd/186

► G-quadruplexes are thought to have biological importance, with studies based on small molecule interactions and quadruplex-interactive antibodies demonstrating their potential for formation in vivo.… (more)

▼ G-quadruplexes are thought to have biological importance, with studies based on small molecule interactions and quadruplex-interactive antibodies demonstrating their potential for formation in vivo. One potential biological function of quadruplex structures is the regulation and maintenance of telomeres. Telomeres are nucleoprotein complexes involved in chromosome stability. Human telomeres are composed of the repeated DNA sequence, 5'- d(TIAGGG), that terminates in a 3' single-stranded overhang. DNA sequences with homology to the human telomere are capable of quadruplex formation in vitro. Specifically, sequences containing four-guanine stretches (e.g. 5'-d(AGGG(TIAGGGb)) are capable of forming at least five distinct unimolecular structures. Which structure is favored is believed to be linked to solvent composition and the addition of 3'- and 5'-flanking residues. This dissertation provides an essential biophysical investigation of the polymorphic equilibrium displayed by human telomeric quadruplexes. Multiple biophysical techniques are utilized to assemble a thermodynamic description of the influences of hydration and molecular crowding on conformational selection and elucidate complex unfolding mechanisms with unique intermediate states. This dissertation provides the first application of phasor diagrams in the study of quadruplexes. Phasor diagrams are shown to be sensitive to alterations in quadruplex structure (i.e. folding and unfolding) by monitoring changes in the complex lifetime distribution of 2-aminopurine. This dissertation contains the first multi-faceted biophysical investigation of the underlying mechanism of co-solvent driven conformational changes of human telomeric quadruplexes. The thermodynamic study illustrates that quadruplexes are stabilized by dehydration, a behavior opposite that of canonical duplex structures. Additionally, the ability of PEGs to drive the conformational selection of a parallel quadruplex through differential binding is clarified, addressing unsubstantiated claims that the propeller form is the most biologically relevant conformation. Finally, an in-depth thermodynamic investigation of the thermal unfolding of human telomeric quadruplexes is conducted. Multiple spectroscopic techniques are used to evaluate the thermal unfolding process and characterize potential intermediates states. This dissertation work is the first to apply spectroscopic deconvolutions to demonstrate that human telomeric quadruplexes unfold through sequential mechanisms requiring intermediate species. These results are highlighted by the recovery of an intermediate species whose biophysical description is best characterized by an ensemble of triple-helical conformations. Advisors/Committee Members: Chaires, Jonathan Bradford.

Subjects/Keywords: Quadruplex; unfolding; telomere; polymorphism; spectroscopy; biophysical

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Buscaglia, R. (2012). The dynamic equilibrium of human telomeric G-quadruplexes. (Doctoral Dissertation). University of Louisville. Retrieved from 10.18297/etd/186 ; https://ir.library.louisville.edu/etd/186

Chicago Manual of Style (16^th Edition):

Buscaglia, Robert. “The dynamic equilibrium of human telomeric G-quadruplexes.” 2012. Doctoral Dissertation, University of Louisville. Accessed February 27, 2020. 10.18297/etd/186 ; https://ir.library.louisville.edu/etd/186.

MLA Handbook (7^th Edition):

Buscaglia, Robert. “The dynamic equilibrium of human telomeric G-quadruplexes.” 2012. Web. 27 Feb 2020.

Vancouver:

Buscaglia R. The dynamic equilibrium of human telomeric G-quadruplexes. [Internet] [Doctoral dissertation]. University of Louisville; 2012. [cited 2020 Feb 27]. Available from: 10.18297/etd/186 ; https://ir.library.louisville.edu/etd/186.

Council of Science Editors:

Buscaglia R. The dynamic equilibrium of human telomeric G-quadruplexes. [Doctoral Dissertation]. University of Louisville; 2012. Available from: 10.18297/etd/186 ; https://ir.library.louisville.edu/etd/186

Universidade Federal da Bahia

28. Paulo Jose Lima Juiz. Association between HLA abd chronic severe periodontitis.

Degree: 2005, Universidade Federal da Bahia

URL: http://www.bibliotecadigital.ufba.br/tde_busca/arquivo.php?codArquivo=2022

►

A doença periodontal (DP) é representada por um conjunto de processos inflamatórios e infecciosos que acometem os tecidos periodontais, de etiologia multifatorial, localização sítiodepedente, caracterizada… (more)

▼

A doença periodontal (DP) é representada por um conjunto de processos inflamatórios e infecciosos que acometem os tecidos periodontais, de etiologia multifatorial, localização sítiodepedente, caracterizada pela interação microrganismo-hospedeiro na superfície do periodonto. Tradicionalmente, a periodontite era analisada estritamente segundo o agente etiológico bacteriano resultado de uma infecção subgengival por um biofilme dental onde os principais microrganismos colonizadores são Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans e Tanerella forsythensis. Somente parte da variabilidade da doença periodontal na população pode ser explicada levando em questão a etiologia bacteriana. É sabido que a susceptibilidade a DP esta relacionada também a uma predisposição genética. No presente estudo foi investigada a associação entre o HLA e a Periodontite crônica severa (PCS) em pacientes mestiços, na faixa etária de 30 a 50 anos, sem distúrbios sistêmicos, residentes em Salvador-BA. Um total de 84 indivíduos foi estudado, sendo 43 pacientes com periodontite crônica severa e 41 indivíduos sem periodontite que constituíram o grupo controle. A avaliação dos parâmetros clínicos se fez por meio do índice de placa visível, índice de sangramento gengival, profundidade de sondagem, recessão gengival, nível de inserção clínica, grau de mobilidade dental e grau de envolvimento de furca. Dentes com coroa totalmente destruída por cárie, com aparelho ortodôntico fixo e parcialmente erupcionados foram excluídos do estudo. A determinação dos alelos dos loci DRB e DQB foi feita pelo método PCR-SSP. Não foi observada diferença estatisticamente significante entre as freqüências dos alelos identificados no grupo de pacientes com PCS e no grupo controle.

Periodontitis is a chronic inflammatory disease of the supporting tissues of the teeth. The gram negative facultative anaerobe Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans and Tanerella forsythensis are implicated as the pathogens in periodontitis. In recent years, convincing evidence has emerged that individual susceptibility to the microbial challenging is determined in part by a genetic predisposition. The aim of the present study was therefore to investigate the incidence of HLA association in 43 patients with severe chronic periodontitis in comparison to 41 probands without periodontits, age of 30-50 years, mestizos, living in Salvador-BA. The clinical assessment included determination of the following parameters: anamnese, visible plaque index, sulcular bleeding index, clinical probing depth, clinical attachment loss and mobility. HLA typing was performed using molecular (PCR-SSP) techniques to DRB and DQB loci. No association with HLA allele frequencies was found in patients relative to controls.

Advisors/Committee Members: Denise Carneiro Lemaire, Paloma Dias da Silva Telles, Eneida de Moraes Marcilio Cerqueira.

Subjects/Keywords: HLA; periodontitis; periodontite; polimorfismo; IMUNOLOGIA; HLA; polymorphism

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Juiz, P. J. L. (2005). Association between HLA abd chronic severe periodontitis. (Thesis). Universidade Federal da Bahia. Retrieved from http://www.bibliotecadigital.ufba.br/tde_busca/arquivo.php?codArquivo=2022

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Juiz, Paulo Jose Lima. “Association between HLA abd chronic severe periodontitis.” 2005. Thesis, Universidade Federal da Bahia. Accessed February 27, 2020. http://www.bibliotecadigital.ufba.br/tde_busca/arquivo.php?codArquivo=2022.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Juiz, Paulo Jose Lima. “Association between HLA abd chronic severe periodontitis.” 2005. Web. 27 Feb 2020.

Vancouver:

Juiz PJL. Association between HLA abd chronic severe periodontitis. [Internet] [Thesis]. Universidade Federal da Bahia; 2005. [cited 2020 Feb 27]. Available from: http://www.bibliotecadigital.ufba.br/tde_busca/arquivo.php?codArquivo=2022.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Juiz PJL. Association between HLA abd chronic severe periodontitis. [Thesis]. Universidade Federal da Bahia; 2005. Available from: http://www.bibliotecadigital.ufba.br/tde_busca/arquivo.php?codArquivo=2022

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Minnesota

29. Hamilton, Benjamin Dale. The influence of nanoscale size confinement on the phase behavior of molecular organic crystals.

Degree: PhD, Chemical Engineering, 2009, University of Minnesota

URL: http://purl.umn.edu/54432

► This thesis details the evolution of the crystallization of molecular organic compounds under nanoconfinement. Within the confines of nanoporous matrices, crystals are limited to sizes… (more)

▼ This thesis details the evolution of the crystallization of molecular organic compounds under nanoconfinement. Within the confines of nanoporous matrices, crystals are limited to sizes comparable to their critical sizes, where their unfavorable surface energy outweights their favorable volume energy. The central contribution of this thesis is the crystallization of glycine within nanoporous matrices. Namely, crystallization of glycine by evaporation of aqueous solutions in nanometer-scale channels of controlled-pore glass (CPG) powders and porous polystyrene-poly(dimethyl acrylamide) (p-PS-PDMA) monoliths, the latter prepared by etching polylactide (PLA) from aligned PS-PDMA-PLA triblock copolymers, preferentially results in exclusive formation of the beta polymorph, which is not observed during crystallization in bulk form under identical conditions. X-ray diffraction (XRD) reveals that the dimensions of the embedded crystals are commensurate with the pore diameter of the matrix. Beta glycine persists for at least one year in CPG and p-PS-PDMA with pore diameters less than 24 nm, but it transforms slowly to alpha glycine over several days when confined within 55 nm CPG. Moreover, variable temperature XRD reveals that beta glycine nanocrystals embedded within CPG are stable at temperatures at which bulk beta glycine ordinarily transforms to the alpha form in the bulk. XRD and differential scanning calorimetry (DSC) reveal the melting of glycine nanocrystals within CPG below the temperature at which bulk glycine melts with concomitant decomposition. The melting point depression conforms to the Gibb-Thompson equation, with the melting points decreasing with decreasing pore size. This behavior permits an estimation of the melting temperature of bulk beta glycine, which cannot be measured directly owing to its metastable nature. Collectively, these results demonstrate size-dependent polymorphism for glycine and the ability to examine certain thermal properties under nanoscale confinement that cannot be obtained in bulk form. The observation of beta glycine at nanometer-scale dimensions suggests that glycine crystallization likely involves formation of beta nuclei followed by their transformation to the other more stable forms as crystal size increases, in accord with Ostwald's rule of stages. When embedded in p-PS-PDMA, the nanocrystals also adopt preferred orientations with their fast-growth axes aligned parallel with the pore direction. When grown from aqueous solutions alone, the nanocrystals were oriented with their [010] and [0-10] axes, the native fast growth directions of the (+) and (-) enantiomorphs of beta glycine, respectively, aligned parallel with the pore direction. In contrast, crystallization in the presence of racemic mixtures of chiral auxiliaries known to inhibit growth along the [010] and [0-10] directions of the enantiomorphs produced beta glycine nanocrystals with their <001> axes nearly parallel to the pore direction. Enantiopure auxiliaries that inhibit crystallization along the native fast growth…

Subjects/Keywords: Crystal; Glycine; Nanoporous; Polymorphism; Chemical Engineering

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hamilton, B. D. (2009). The influence of nanoscale size confinement on the phase behavior of molecular organic crystals. (Doctoral Dissertation). University of Minnesota. Retrieved from http://purl.umn.edu/54432

Chicago Manual of Style (16^th Edition):

Hamilton, Benjamin Dale. “The influence of nanoscale size confinement on the phase behavior of molecular organic crystals.” 2009. Doctoral Dissertation, University of Minnesota. Accessed February 27, 2020. http://purl.umn.edu/54432.

MLA Handbook (7^th Edition):

Hamilton, Benjamin Dale. “The influence of nanoscale size confinement on the phase behavior of molecular organic crystals.” 2009. Web. 27 Feb 2020.

Vancouver:

Hamilton BD. The influence of nanoscale size confinement on the phase behavior of molecular organic crystals. [Internet] [Doctoral dissertation]. University of Minnesota; 2009. [cited 2020 Feb 27]. Available from: http://purl.umn.edu/54432.

Council of Science Editors:

Hamilton BD. The influence of nanoscale size confinement on the phase behavior of molecular organic crystals. [Doctoral Dissertation]. University of Minnesota; 2009. Available from: http://purl.umn.edu/54432

Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

30. Deligiannidis, Aristeidis. Γενετικός πολυμορφισμός των προαγουσών τη φλεγμονή κυτταροκινών και του TGF-β σε ασθενείς με έμφραγμα του μυοκαρδίου.

Degree: 2015, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

URL: http://hdl.handle.net/10442/hedi/37127

►

As it is known, myocardial infarction and the local necrosis it causes to the myocardium, is a source of inflammation. As in every case of… (more)

▼

As it is known, myocardial infarction and the local necrosis it causes to the myocardium, is a source of inflammation. As in every case of inflammation, the immune system activates, producing cytokines, as a response to the inflicted necrosis, promoting scar formation. This mechanism often acts against the best interest of the organism, leaving a dysfunctional remain of tissue.In genetic level, serious research has taken place in order to combine the polymorphisms of these cytokines and the proteins they produce, either concerning the quantity or their quality, with the frequency of appearance and the way diseases evolve.In our research, we located the most popular and most studied polymorphisms of a pliad of cytokines found in the peripheral blood of patients with myocardial infarction. We compared statistically the results with that of a healthy group of people sharing common characteristics (age, sex, risk factors) and ethnical identity (Greek).We took sample from 65 patients with myocardial infarction and 102 healthy people as control group. DNA extraction was done using the PureLink® Genomic DNA Kit. while its decoding was done using the luminex method. The results was later analyzed using the internet statistical package SNPstats, which specializes in single noucleotid polymorphisms. The aforementioned package is free to use at http://bioinfo.iconcologia.net/SNPstats. The level of significance we used was p<0,05.Studying the bibliography until today, the results concerning each cytokine in separate appear to vary and often are conflicting. The geographical factor seems to play an important role, influencing the results. Our study piles up to the total of the scientific knowledge that there is no relation between myocardial infarction and TGFβ +869, +917, IFNγ +874, IL10 -1082, -819, IL6 -174, TNFα -238, -308, IL12β +1188, IL1α -889. IL1β -511, +3962 and IL1R pst11970 polymorphisms, at least as long as Greek population is concerned. In contrary, there was a firm relation between the disease and the existence of C allele at position -592 of IL10 of our female population. Identically, there seems to be a protective role of the CT genotype, of IL1Ra at gene position mspal11100, to its carriers.We suggest that research continues in this direction, taking seriously in concern the geographical factor, expanding in greater numbers of populations, separating myocardial infarction in STEMI and NSTEMI and finally trying if possible to study various combinations of polymorphisms, either concerning the same cytokine or not, as a unified risk factor of myocardial infarction’s appearance.

Είναι γνωστό πως το έμφραγμα του μυοκαρδίου και η τοπική νέκρωση που προκαλεί στο μυοκάρδιο αποτελεί εστία φλεγμονής του οργανισμού. Όπως σε κάθε περίπτωση φλεγμονής, κινητοποιείται ο ανοσοποιητικός μηχανισμός, με βασικό εκπρόσωπο τις παραγόμενες κυτταροκίνες, αντιμαχόμενος τη νεκρωτική περιοχή και προάγοντας την ουλοποίηση. Ο μηχανισμός αυτός, πολλές φορές δεν επενεργεί υπέρ του συμφέροντος του οργανισμού, εγκαταλείποντας δυσλειτουργικό…

Subjects/Keywords: Πολυμορφισμός; Κυτταροκίνες; Έμφραγμα; Polymorphism; Cytokines; Infarction

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Deligiannidis, A. (2015). Γενετικός πολυμορφισμός των προαγουσών τη φλεγμονή κυτταροκινών και του TGF-β σε ασθενείς με έμφραγμα του μυοκαρδίου. (Thesis). Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Retrieved from http://hdl.handle.net/10442/hedi/37127

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Deligiannidis, Aristeidis. “Γενετικός πολυμορφισμός των προαγουσών τη φλεγμονή κυτταροκινών και του TGF-β σε ασθενείς με έμφραγμα του μυοκαρδίου.” 2015. Thesis, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Accessed February 27, 2020. http://hdl.handle.net/10442/hedi/37127.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Deligiannidis, Aristeidis. “Γενετικός πολυμορφισμός των προαγουσών τη φλεγμονή κυτταροκινών και του TGF-β σε ασθενείς με έμφραγμα του μυοκαρδίου.” 2015. Web. 27 Feb 2020.

Vancouver:

Deligiannidis A. Γενετικός πολυμορφισμός των προαγουσών τη φλεγμονή κυτταροκινών και του TGF-β σε ασθενείς με έμφραγμα του μυοκαρδίου. [Internet] [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2015. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/10442/hedi/37127.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Deligiannidis A. Γενετικός πολυμορφισμός των προαγουσών τη φλεγμονή κυτταροκινών και του TGF-β σε ασθενείς με έμφραγμα του μυοκαρδίου. [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2015. Available from: http://hdl.handle.net/10442/hedi/37127

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations