subject:(Polymorphism)

University of Waikato

1. Mulholland, Claire Vignette. Single nucleotide polymorphisms associated with the human electroencephalogram during desflurane anaesthesia .

Degree: 2012, University of Waikato

URL: http://hdl.handle.net/10289/6678

► General anaesthesia is an induced state that enables a person to endure surgical procedures without pain or recollection. There is substantial individual variability in the… (more)

▼ General anaesthesia is an induced state that enables a person to endure surgical procedures without pain or recollection. There is substantial individual variability in the response to anaesthesia and in order to avoid adverse effects caused by either under- or over-sedation, anaesthetic drug administration must be tailored to suit the individual patient. This requires a means to monitor the depth of general anaesthesia. The electroencephalogram (EEG) records the electrical activity of the brain and enables effects of anaesthetic drugs on brain functioning to be monitored. Quantitative EEG monitors, such as the Bispectral (BIS) index monitor, process the raw EEG and provide a numerical output that is often used to measure the depth of general anaesthesia during surgery. Due to a number of factors including clinical conditions and genetic variability in the EEG, the BIS value can at times be misleading. To identify genetic variations associated with EEG phenotypes relevant to anaesthesia monitoring, an association analysis was performed for 34 single nucleotide polymorphisms (SNPs) in a sample of 125 surgical patients undergoing general, gynaecological or orthopaedic surgery. During surgery, patients were anaesthetised with the volatile anaesthetic agent desflurane, the depth of anaesthesia was measured using BIS monitoring and the raw was also EEG recorded. SNP genotyping was performed for 13 SNPs in five candidate genes; SGIP1, GABRA2, CACNA1G, HCN1 and HCN2, using the polymerase chain reaction and restriction fragment length polymorphism analysis. An additional 21 SNPs in 15 genes involved in various inflammatory and other immune-related pathways were genotyped by Sequenom MassARRAY at the Australian Genome Research Facility. Six SNPs in five different genes were found to be associated with spindle amplitude (SGIP1, GABRA2, HCN1, IL1B and MYD88), and a further five SNPs were associated with either delta frequency (IL10), or end tidal desflurane concentration (ETDC) (CACNA1G, CRP, MYD88 and TGFB1). The strongest associations were identified for a single SNP located in the 3' UTR of MYD88 (rs6853). The rs6853 A/G genotype was associated with higher median spindle amplitude (p = 0.0040) and spindle amplitude relative to ETDC (p = 0.0006), and lower EDTC (p = 0.0095) than the A/A genotype. No rs6853 G/G homozygotes were identified in the study sample. MYD88 acts as an adaptor protein in the interleukin-1 receptor and toll-like receptor signalling pathways. Within the brain, cytokines are thought to act as neuronal modulators and influence neurotransmitter signalling and ion channel activity. The association of MYD88 with spindle amplitude, in conjunction with IL1B, suggests that cytokines may influence the EEG during general anaesthesia. Thus cytokine mediated regulation of neuronal activity is speculated to underlie the reported associations. All reported effect sizes were small (0.77- to 1.55-fold) and associated genes had four distinct types of function; ion channels, neurotransmitter signalling, endocytosis,… Advisors/Committee Members: Cursons, Raymond T (advisor).

Subjects/Keywords: single nucleotide polymorphism; polymorphism; SNP; anaesthesia; electroencephalogram

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mulholland, C. V. (2012). Single nucleotide polymorphisms associated with the human electroencephalogram during desflurane anaesthesia . (Masters Thesis). University of Waikato. Retrieved from http://hdl.handle.net/10289/6678

Chicago Manual of Style (16^th Edition):

Mulholland, Claire Vignette. “Single nucleotide polymorphisms associated with the human electroencephalogram during desflurane anaesthesia .” 2012. Masters Thesis, University of Waikato. Accessed February 27, 2021. http://hdl.handle.net/10289/6678.

MLA Handbook (7^th Edition):

Mulholland, Claire Vignette. “Single nucleotide polymorphisms associated with the human electroencephalogram during desflurane anaesthesia .” 2012. Web. 27 Feb 2021.

Vancouver:

Mulholland CV. Single nucleotide polymorphisms associated with the human electroencephalogram during desflurane anaesthesia . [Internet] [Masters thesis]. University of Waikato; 2012. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10289/6678.

Council of Science Editors:

Mulholland CV. Single nucleotide polymorphisms associated with the human electroencephalogram during desflurane anaesthesia . [Masters Thesis]. University of Waikato; 2012. Available from: http://hdl.handle.net/10289/6678

2. Μανίκα, Γεωργία. Πολυμορφισμός Aripiprazole και μέθοδοι ταυτοποίησης και ποσοστικής ανάλυσης.

Degree: 2014, University of Patras

URL: http://hdl.handle.net/10889/8004

► Several active pharmaceutical ingredients (API) exhibit polymorphism i.e. the ability of a solid material to exist in more than one form or crystal structure (polymorphs).… (more)

▼ Several active pharmaceutical ingredients (API) exhibit polymorphism i.e. the ability of a solid material to exist in more than one form or crystal structure (polymorphs). The polymorphs differ somewhat in physical and, sometimes, chemical properties, although their solutions and vapours are identical. Among the different physical properties that are affected by polymorphism are solubility and dissolution rate which have great impact on the bioavailability of the drug. Frequently an API polymorph transforms to another, more thermodynamically stable, phase. When such transformation takes place then a pharmaceutical industry faces problems related to bioavailability of an API as well as litigation problems due to patent protection of specific polymorphs. The pharmaceutical substance that was studied in this current work was, Aripiprazole, an antipsychotic drug. API crystallizes in a large number of polymorphic and solvatomorphic phases. Μore specific 9 polymorphic and 9 solvatomorphic phases have been positively identified, from which Form III and Form V are currently tested as possible candidates for drug formulations. The objective of the present work was to establish methods capable of identification and quantification of Apiprazole crystal forms and their possible transformation to hydrate phase in Aripiprazole powders as well as in the tested tablets. Stability test were also performed on Aripiprazole crystal forms III and V. The analytical techniques applied were X-ray Powder Diffraction (XRPD), Infrared spectroscopy (IR) and Raman spectroscopy. Calibration lines of mixtures of API Form III and Monohydrate were constructed. Results show that all three techniques were capable of identifying and quantifying the monohydrate phase however XRPD is probably the method of choice due to the lower detection limit (0.34%) of monohydrate in Phase III-monohydrate mixtures. Quantitative analysis of these polymorphs in the presence of excipients (tablets) is difficult due to the rather low API percentage in tablets (8%) and the high detection limits of monohydrate in mixtures of III and monohydrate. An effort to increase the low API content was made by dissolving in water a large percentage of excipients at alkaline pH. Even though the stability tests show that no transformation of pure Phase III occurs under these conditions, in tablets with some presence of monohydrate, rapid transformation of the remaining Phase III was observed during the dissolution process of the excipients. Thus, the only way was to apply directly the analytical techniques that were used for the pure mixtures to tablets. It was found that Raman and IR spectra cannot be used due to heavy overlapping with excipients bands. By increasing the scan time the identification of anhydrate phase and the hydrate was possible by using XRPD. In order to avoid any possible transformation of both Form III and Form V (stability tests show transformation to hydrate phase) it was decided to build the calibration line using only the hydrate phase and the placebo. The… Advisors/Committee Members: Κοντογιάννης, Χρίστος, Manika, Georgia, Όρκουλα, Μαλβίνα, Κλεπετσάνης, Παύλος, Κοντογιάννης, Χρίστος.

Subjects/Keywords: Polymorphism; Aripiprazole; Πολυμορφισμός

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APA (6^th Edition):

Μανίκα, �. (2014). Πολυμορφισμός Aripiprazole και μέθοδοι ταυτοποίησης και ποσοστικής ανάλυσης. (Masters Thesis). University of Patras. Retrieved from http://hdl.handle.net/10889/8004

Chicago Manual of Style (16^th Edition):

Μανίκα, Γεωργία. “Πολυμορφισμός Aripiprazole και μέθοδοι ταυτοποίησης και ποσοστικής ανάλυσης.” 2014. Masters Thesis, University of Patras. Accessed February 27, 2021. http://hdl.handle.net/10889/8004.

MLA Handbook (7^th Edition):

Μανίκα, Γεωργία. “Πολυμορφισμός Aripiprazole και μέθοδοι ταυτοποίησης και ποσοστικής ανάλυσης.” 2014. Web. 27 Feb 2021.

Vancouver:

Μανίκα �. Πολυμορφισμός Aripiprazole και μέθοδοι ταυτοποίησης και ποσοστικής ανάλυσης. [Internet] [Masters thesis]. University of Patras; 2014. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10889/8004.

Council of Science Editors:

Μανίκα �. Πολυμορφισμός Aripiprazole και μέθοδοι ταυτοποίησης και ποσοστικής ανάλυσης. [Masters Thesis]. University of Patras; 2014. Available from: http://hdl.handle.net/10889/8004

Univerzitet u Beogradu

3. Živanović, Dubravka P., 1970-. Polimorfizam HLA-DR i HLA-DQ alela kod pacijenata sa pemfigus vulgarisom.

Degree: Medicinski fakultet, 2016, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:14064/bdef:Content/get

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Medicina - Dermatovenerologija / Medicine - Dermatology

Uvod: Pemphigus vulgaris (PV) pripada grupi organ specifičnih autoimunskih oboljenja, kod koga se stvaraju autoantitela usmerena na specifične… (more)

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Medicina - Dermatovenerologija / Medicine - Dermatology

Uvod: Pemphigus vulgaris (PV) pripada grupi organ specifičnih autoimunskih oboljenja, kod koga se stvaraju autoantitela usmerena na specifične proteine (antigene) kože i sluzokoža. Autoantitela kod pemfigusa su usmerena prema komponentama međućelijskih spojeva (dezmozomima). To su dezmoglein 3 (Dsg 3), u manjoj meri dezmoglein 1 (Dsg 1) i drugi proteini. Kao posledica vezivanja cirkulišućih antitela za proteine dezmozoma dolazi do cepanja međućelijskih spojeva (akantolize) i pojave plikova (bula) na koži i sluzokožama. Autoimunski pemfigus, kao i druge autoimunske bolesti, predstavlja multifaktorsko oboljenje, rizik od nastanka bolesti zavisi od složenih interakcija gena i faktora spoljašnje sredine. U okviru naslednih faktora u etiopatogenezi pemfigusa najviše je ispitivan kompleks gena tkivne podudarnosti koji kodira sistem humanih leukocitnih antigena (HLA). HLA je najpolimorfniji deo humanog genoma. Složenost polimorfizma HLA je posledica postojanja više genskih lokusa, velikog broja alela za većinu gena i kombinacija produkata ovih alela. HLA molekuli II klase su posebno značajni jer prikazuju peptide CD4+ T-limfocitima pod čijom kontrolom je sekrecija anti Dsg 3 i anti Dsg 1 antitela od strane B-limfocita. Do sada je dokazana udruženost pojedinih HLA alela sa većim brojem autoimunskih oboljenja uključujući i pemfigus. Ciljevi istraživanja: Ciljevi ovog istraživanja su bili da se ustanovi učestalost alela i haplotipova u HLA-DR i DQ lokusima kod pacijenata sa PV u Srbiji, da se ustanovi stepen genetske sličnosti sa obolelima od PV u drugim populacijama, kao i da se ispita korelacija između genotipova, težine bolesti i koncentracije Dsg1 i Dsg3 antitela. Ispitanici i metode: Ispitivanje je izvršeno kod 72 pacijenta sa dokazanim PV. Kod ispitanika je određena alelska učestalost u HLA-DR i DQ lokusima (DRB1*, DQB1* i DQA1*). Izolacija DNK je rađena upotrebom QIAamp DNA Blood Mini Kit-a (QIAGEN, Germany). Određivanje grupa alela ispitivanih lokusa je rađeno testovima niske/srednje rezolucije, a potom su testovima visoke rezolucije određivani aleli upotrebom prajmera specifičnih za alelsku sekvencu PCR-SSP (engl. Polymerase chain reaction with sequence-specific primers) prema preporukama proizvođača testova (BAG lich Germany i Invitrogen)...

Advisors/Committee Members: Medenica, Ljiljana, 1951-.

Subjects/Keywords: HLA; polymorphism; pemphigus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Živanović, Dubravka P., 1. (2016). Polimorfizam HLA-DR i HLA-DQ alela kod pacijenata sa pemfigus vulgarisom. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:14064/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Živanović, Dubravka P., 1970-. “Polimorfizam HLA-DR i HLA-DQ alela kod pacijenata sa pemfigus vulgarisom.” 2016. Thesis, Univerzitet u Beogradu. Accessed February 27, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:14064/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Živanović, Dubravka P., 1970-. “Polimorfizam HLA-DR i HLA-DQ alela kod pacijenata sa pemfigus vulgarisom.” 2016. Web. 27 Feb 2021.

Vancouver:

Živanović, Dubravka P. 1. Polimorfizam HLA-DR i HLA-DQ alela kod pacijenata sa pemfigus vulgarisom. [Internet] [Thesis]. Univerzitet u Beogradu; 2016. [cited 2021 Feb 27]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:14064/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Živanović, Dubravka P. 1. Polimorfizam HLA-DR i HLA-DQ alela kod pacijenata sa pemfigus vulgarisom. [Thesis]. Univerzitet u Beogradu; 2016. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:14064/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manchester

4. Dowling, Richard John. A study of the nucleation and growth of glycine and DL-alanine.

Degree: PhD, 2012, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/a-study-of-the-nucleation-and-growth-of-glycine-and-dlalanine(a8af960d-43e1-4ef8-a552-53dee7a03f76).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555540

► A clear and predictive understanding of the propensity for crystallisation of one polymorph over another is lacking, and in this regard glycine is a model… (more)

▼ A clear and predictive understanding of the propensity for crystallisation of one polymorph over another is lacking, and in this regard glycine is a model system due to difficulties in crystallisation of the thermodynamically stable gamma polymorph. The preferential crystallisation of gamma-glycine in the presence of micellar CTAB (Cetyltrimethylammonium bromide) as opposed to the alpha form commonly crystallised from pure solution was observed. A rationale for this result was sought through the observation of the nucleation and growth kinetics of the alpha and gamma polymorphs of glycine (and DL-alanine) using in situ microscopy, the measurement of induction times and following the solution mediated phase transformation of alpha-glycine. These observations help explain the dominant crystal form produced in a number of solutions. The nucleation and growth rates of alpha-glycine were shown to be orders of magnitude greater than those of gamma-glycine in pure solution. Also, the addition of a cationic surfactant (such as CTAB) or modification of the solution pH were shown to dramatically accelerate the nucleation and growth of polar gamma-glycine and DL-alanine, a rarely reported phenomenon. In addition, the growing (00-1) faces of gamma-glycine and DL-alanine, at which growth was accelerated, were shown to be macroscopically rough, indicating a growth mechanism dominated by nucleation rather than the growth of layers. The most likely cause of the inhibited kinetics of gamma-glycine and DL-alanine is water bound electrostatically at the negatively charged (00-1) faces, while the growth acceleration inferred by the additives is related to their ability to release water from these surfaces. Other mechanisms which may play a role include the adsorption of adventitious impurities, strong electrostatic repulsion between like-charged carboxylate groups at the (00-1) surface resulting in structural disorder, and the effect of surface energy on the rate of surface nucleation. This research provides an important example of nature’s complexity in selecting crystal form in polymorphic systems, gives further insight into the causes of the asymmetric growth of polar crystal structures, and introduces the possibility that the crystallisation kinetics of ‘difficult’ slow growing compounds may sometimes be modified through the use of additives.

Subjects/Keywords: 548; Polymorphism; Kinetics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dowling, R. J. (2012). A study of the nucleation and growth of glycine and DL-alanine. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/a-study-of-the-nucleation-and-growth-of-glycine-and-dlalanine(a8af960d-43e1-4ef8-a552-53dee7a03f76).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555540

Chicago Manual of Style (16^th Edition):

Dowling, Richard John. “A study of the nucleation and growth of glycine and DL-alanine.” 2012. Doctoral Dissertation, University of Manchester. Accessed February 27, 2021. https://www.research.manchester.ac.uk/portal/en/theses/a-study-of-the-nucleation-and-growth-of-glycine-and-dlalanine(a8af960d-43e1-4ef8-a552-53dee7a03f76).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555540.

MLA Handbook (7^th Edition):

Dowling, Richard John. “A study of the nucleation and growth of glycine and DL-alanine.” 2012. Web. 27 Feb 2021.

Vancouver:

Dowling RJ. A study of the nucleation and growth of glycine and DL-alanine. [Internet] [Doctoral dissertation]. University of Manchester; 2012. [cited 2021 Feb 27]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/a-study-of-the-nucleation-and-growth-of-glycine-and-dlalanine(a8af960d-43e1-4ef8-a552-53dee7a03f76).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555540.

Council of Science Editors:

Dowling RJ. A study of the nucleation and growth of glycine and DL-alanine. [Doctoral Dissertation]. University of Manchester; 2012. Available from: https://www.research.manchester.ac.uk/portal/en/theses/a-study-of-the-nucleation-and-growth-of-glycine-and-dlalanine(a8af960d-43e1-4ef8-a552-53dee7a03f76).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555540

University of Manchester

5. Raginis-Zborowska, Alicja Iwona. Unravelling the genetic basis for cortical plasticity in the human swallowing motor system.

Degree: 2016, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306466

► Swallowing is an important physiological function leading to nourishment of the organism, controlled by complicated interactions between the muscles, the cranial nerves and multiple brain… (more)

▼ Swallowing is an important physiological function leading to nourishment of the organism, controlled by complicated interactions between the muscles, the cranial nerves and multiple brain structures. Swallowing impairments, also called dysphagia are a major health burden for patients with neurological diseases such as stroke, Parkinson’s disease as well as community dwelling elderly individuals. It has been shown that activation of undamaged swallowing motor cortex compensates for the initial lost swallowing function in stroke patients. Non-invasive brain stimulation provides a tool to explore excitability within the areas of the motor cortex responsible for swallowing muscles. Repetitive transcranial magnetic stimulation (rTMS) is one such technique, with defined frequency parameters, however the underlying reasons for the heterogeneity is responses to low (1Hz) and high (5Hz) frequencies is unclear. These physiological interactions affecting the neurological control of swallowing may be influenced by multiple genes and proteins. Insights into the molecular basis of swallowing through genetic interactions could provide a source of information which can be further used in understanding and treating swallowing impairments. Existing evidence is limited in terms of candidate proteins, genes and pathways which might drive the neural control of swallowing.The aim of my doctoral research was to explore genes which might be involved in swallowing neurophysiology and pathophysiology. My hypothesis is that swallowing due to its complicated physiology is most likely affected by multiple genes and interactions between genes and proteins.To study this hypothesis I used two experimentally distinct study designs. Firstly I explored a number of single nucleotide polymorphisms (SNPs) and potential candidate genes presented in the existing literature. Then, I performed a SNP- and gene-based Genome-Wide Association Study (GWAS) of self-reported swallowing impairments compared with over 500,000 single nucleotide changes. For GWAS I used a group of 555 community dwelling individuals from the Dyne Steel Cohort from the areas of Manchester and Newcastle. Further research involved replication of selected genes and SNPs from literature screening and GWAS using two rTMS paradigms on the largest to date cohort of healthy young volunteers. Forty one volunteers (were assessed for corticobulbar excitability after single-pulse TMS. Repeated measurements of motor evoked potentials from the pharynx and the hand were recorded after the interventions of 1Hz and 5Hz rTMS. The subjects’ individual responses were grouped according to multiple criteria and then associated with factors such as gender, ethnicity, time of day of the stimulation and individual genetic information.GWAS analysis for association with swallowing impairment identified one SNP rs17601696 which achieved genome-wide significance (P-value=5×10(-8)) within a non-coding region of chromosome 10. Gene-based analysis did not result in any genome-wide significant association. In… Advisors/Committee Members: OLLIER, WILLIAM WE, HAMDY, SHAHEEN S, Ollier, William, Pendleton, Neil, Hamdy, Shaheen.

Subjects/Keywords: swallowing; dysphagia; rTMS; polymorphism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Raginis-Zborowska, A. I. (2016). Unravelling the genetic basis for cortical plasticity in the human swallowing motor system. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306466

Chicago Manual of Style (16^th Edition):

Raginis-Zborowska, Alicja Iwona. “Unravelling the genetic basis for cortical plasticity in the human swallowing motor system.” 2016. Doctoral Dissertation, University of Manchester. Accessed February 27, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306466.

MLA Handbook (7^th Edition):

Raginis-Zborowska, Alicja Iwona. “Unravelling the genetic basis for cortical plasticity in the human swallowing motor system.” 2016. Web. 27 Feb 2021.

Vancouver:

Raginis-Zborowska AI. Unravelling the genetic basis for cortical plasticity in the human swallowing motor system. [Internet] [Doctoral dissertation]. University of Manchester; 2016. [cited 2021 Feb 27]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306466.

Council of Science Editors:

Raginis-Zborowska AI. Unravelling the genetic basis for cortical plasticity in the human swallowing motor system. [Doctoral Dissertation]. University of Manchester; 2016. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306466

Mahatma Gandhi University

6. Nileena, C B. Detailed studies on the genera and species of the family Podostemaceae with particular reference to the phenomenon of polymorphism; -.

Degree: Botany, 2013, Mahatma Gandhi University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/6494

References p.179-190 Advisors/Committee Members: Mathew, C Joyce.

Subjects/Keywords: Botany; polymorphism

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APA (6^th Edition):

Nileena, C. B. (2013). Detailed studies on the genera and species of the family Podostemaceae with particular reference to the phenomenon of polymorphism; -. (Thesis). Mahatma Gandhi University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/6494

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nileena, C B. “Detailed studies on the genera and species of the family Podostemaceae with particular reference to the phenomenon of polymorphism; -.” 2013. Thesis, Mahatma Gandhi University. Accessed February 27, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/6494.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nileena, C B. “Detailed studies on the genera and species of the family Podostemaceae with particular reference to the phenomenon of polymorphism; -.” 2013. Web. 27 Feb 2021.

Vancouver:

Nileena CB. Detailed studies on the genera and species of the family Podostemaceae with particular reference to the phenomenon of polymorphism; -. [Internet] [Thesis]. Mahatma Gandhi University; 2013. [cited 2021 Feb 27]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/6494.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nileena CB. Detailed studies on the genera and species of the family Podostemaceae with particular reference to the phenomenon of polymorphism; -. [Thesis]. Mahatma Gandhi University; 2013. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/6494

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Delft University of Technology

7. Wursten, N. (author). Cooling crystallization under influence of a strong DC electric field.

Degree: 2012, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:51ebd4ab-7816-49bf-85da-9395ec1bab3f

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Polymorphism is the ability of solid material to exist in more than one form or crystal structure. It is especially important for the pharmaceutical industry,… (more)

Subjects/Keywords: cooling crystallization; electric field; polymorphism

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APA (6^th Edition):

Wursten, N. (. (2012). Cooling crystallization under influence of a strong DC electric field. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:51ebd4ab-7816-49bf-85da-9395ec1bab3f

Chicago Manual of Style (16^th Edition):

Wursten, N (author). “Cooling crystallization under influence of a strong DC electric field.” 2012. Masters Thesis, Delft University of Technology. Accessed February 27, 2021. http://resolver.tudelft.nl/uuid:51ebd4ab-7816-49bf-85da-9395ec1bab3f.

MLA Handbook (7^th Edition):

Wursten, N (author). “Cooling crystallization under influence of a strong DC electric field.” 2012. Web. 27 Feb 2021.

Vancouver:

Wursten N(. Cooling crystallization under influence of a strong DC electric field. [Internet] [Masters thesis]. Delft University of Technology; 2012. [cited 2021 Feb 27]. Available from: http://resolver.tudelft.nl/uuid:51ebd4ab-7816-49bf-85da-9395ec1bab3f.

Council of Science Editors:

Wursten N(. Cooling crystallization under influence of a strong DC electric field. [Masters Thesis]. Delft University of Technology; 2012. Available from: http://resolver.tudelft.nl/uuid:51ebd4ab-7816-49bf-85da-9395ec1bab3f

University of Tennessee – Knoxville

8. Peterson, Christopher Ryan. Color, Color Pattern, Habitat Use, and Morphology of Anolis conspersus.

Degree: MS, Ecology and Evolutionary Biology, 2016, University of Tennessee – Knoxville

URL: https://trace.tennessee.edu/utk_gradthes/4302

► Understanding color polymorphism and associated ecological and morphological divergence is important to improving out knowledge of diversity and speciation; anoles are a model clade… (more)

Subjects/Keywords: Anole; Bayesian statistics; color polymorphism

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APA (6^th Edition):

Peterson, C. R. (2016). Color, Color Pattern, Habitat Use, and Morphology of Anolis conspersus. (Thesis). University of Tennessee – Knoxville. Retrieved from https://trace.tennessee.edu/utk_gradthes/4302

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Peterson, Christopher Ryan. “Color, Color Pattern, Habitat Use, and Morphology of Anolis conspersus.” 2016. Thesis, University of Tennessee – Knoxville. Accessed February 27, 2021. https://trace.tennessee.edu/utk_gradthes/4302.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Peterson, Christopher Ryan. “Color, Color Pattern, Habitat Use, and Morphology of Anolis conspersus.” 2016. Web. 27 Feb 2021.

Vancouver:

Peterson CR. Color, Color Pattern, Habitat Use, and Morphology of Anolis conspersus. [Internet] [Thesis]. University of Tennessee – Knoxville; 2016. [cited 2021 Feb 27]. Available from: https://trace.tennessee.edu/utk_gradthes/4302.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Peterson CR. Color, Color Pattern, Habitat Use, and Morphology of Anolis conspersus. [Thesis]. University of Tennessee – Knoxville; 2016. Available from: https://trace.tennessee.edu/utk_gradthes/4302

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Canterbury

9. Bartlett, Michael John. The Evolution and Maintenance of Body Colour Polymorphism in Bombus ruderatus in the South Island, New Zealand.

Degree: MS, Evolutionary Biology, 2013, University of Canterbury

URL: http://dx.doi.org/10.26021/7391

► Explaining the wide range of animal colouration in the natural world is a key issue in evolutionary biology. Bumble bees are often brightly coloured and… (more)

▼ Explaining the wide range of animal colouration in the natural world is a key issue in evolutionary biology. Bumble bees are often brightly coloured and show a range of colours and colour patterns in different species as well as considerable variation within species. The large garden bumble bee, Bombus ruderatus, is highly variable in its degree of black (melanic) colouration, with morphs ranging from the familiar yellow and black bands (banded) through intermediate forms to morphs that are totally melanic. The aim of this research was to determine what might be maintaining the colour polymorphism in populations of B. ruderatus in the South Island, New Zealand. Colouration of worker bees was measured using a digital photography method and found to be significantly different across sample sites. To look at potential adaptive functions of body colour in B. ruderatus, three hypotheses of thermoregulation, desiccation tolerance and Müllerian mimicry were tested by comparing patterns of variation in melanism to patterns of variation in climatic variables (temperature, rainfall, humidity) and abundance of conspecifics. In order to address the possibility that selectively neutral processes were more important than selection, the genetic structure of B. ruderatus populations was characterised and compared to the pattern of variation in melanism. The colouration of individuals from the same population collected at different times in the season was compared to evaluate whether body colour was plastic and any support for the genetic basis of melanism in B. ruderatus was also assessed by determining any relationship between relatedness and degree of melanism. The results suggest that differences in the degree of melanism between populations are greater than the differences expected through selectively neutral forces alone and, therefore, that the pattern of variation in melanism is likely a result of selection and/or phenotypic plasticity in addition to gene flow and genetic drift. Although a global model consisting of four climatic variables and the abundance of conspecifics explained a small proportion of the variation in melanism, no support was found for any specific hypothesis relating to the adaptive function for body colour. Instead the results suggest that some combination of factors, most likely including factors not measured in this study, is influencing the frequency of melanic morphs. In addition, there was evidence that body colour was influenced by phenotypic plasticity and that melanism has a low heritability in B. ruderatus. Taken together, these results imply that patterns of melanism across B. ruderatus populations are complex and it is likely that multiple factors are influencing melanism in concert.

Subjects/Keywords: colour polymorphism; bumble bees; melanism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bartlett, M. J. (2013). The Evolution and Maintenance of Body Colour Polymorphism in Bombus ruderatus in the South Island, New Zealand. (Masters Thesis). University of Canterbury. Retrieved from http://dx.doi.org/10.26021/7391

Chicago Manual of Style (16^th Edition):

Bartlett, Michael John. “The Evolution and Maintenance of Body Colour Polymorphism in Bombus ruderatus in the South Island, New Zealand.” 2013. Masters Thesis, University of Canterbury. Accessed February 27, 2021. http://dx.doi.org/10.26021/7391.

MLA Handbook (7^th Edition):

Bartlett, Michael John. “The Evolution and Maintenance of Body Colour Polymorphism in Bombus ruderatus in the South Island, New Zealand.” 2013. Web. 27 Feb 2021.

Vancouver:

Bartlett MJ. The Evolution and Maintenance of Body Colour Polymorphism in Bombus ruderatus in the South Island, New Zealand. [Internet] [Masters thesis]. University of Canterbury; 2013. [cited 2021 Feb 27]. Available from: http://dx.doi.org/10.26021/7391.

Council of Science Editors:

Bartlett MJ. The Evolution and Maintenance of Body Colour Polymorphism in Bombus ruderatus in the South Island, New Zealand. [Masters Thesis]. University of Canterbury; 2013. Available from: http://dx.doi.org/10.26021/7391

Macquarie University

10. Junqueira Santiago, Marina. Regulation of the μ-opioid receptor signalling in naturally occurring variants and phosphorylation site mutants.

Degree: 2015, Macquarie University

URL: http://hdl.handle.net/1959.14/1068731

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Empirical thesis.

Bibliography: pages 263-303.

1. General introduction and outline – 2. Introduction – 3. Experimental methodology – 4. Desensitisation and kinase modulators – 5.… (more)

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Empirical thesis.

Bibliography: pages 263-303.

1. General introduction and outline – 2. Introduction – 3. Experimental methodology – 4. Desensitisation and kinase modulators – 5. Regulation of N-terminal SNPs of hMOPr – 6. Regulation of TM1 and ICL2 SNPs of hMOPr – 7. The ICL3 : hMOPr SNPs and phosphosite mutants – 8. Regulation of C-terminal phosphosite mutant of hMOPr – 9. Summary and prospects.

Opioid drugs are highly effective for the treatment of moderate to severe nociceptive pain. They exert their analgesic and rewarding effects primarily by signalling through the μ-opioid receptor (MOPr). The focus of this project was to better understand MOPr signalling regulation by investigating natural variants of MOPr and MOPr phosphosite mutants.

Isogenic, stably transfected mouse pituitary adenoma (AtT20) cell lines expressing eight naturally occurring human MOPr variants and four phosphomutants were created. Opioid-stimulated changes in membrane potential were measured using a membrane potential-sensitive dye, while receptor phosphorylation of Ser 377 residue was determined by Western Blot and whole-cell ELISA was used to obtain the receptor surface loss dynamics.

The N-terminal MOPr variants, A6V and N40D, are the most common single-nucleotide polymorphisms found worldwide. Their signalling regulation was quite similar to the wild-type MOPr in each assay, where buprenorphine was the opiod with the most variance observed. In AtT20-hMOPr-L85I cells morphine mediated internalisation was not as substantial as previously reported, while the second intracellular loop (ICL2) polymorphism R181C dramatically impacted receptor ability to signal by affecting opioid affinity and probably G protein binding. The majority of the third intracellular loop (ICL3) variants had detrimental effect in receptor signalling and regulation which indicates the important role this region plays in G protein activation. In addition the multiple phosphorylation mutants also affected membrane expression which was related to endoplasmic reticulum sequestration and possible changes in receptor stability. Finally, deleting all the putative phosphorylation sites in the human MOPr C-terminal domain did not greatly influence homologous desensitisation of the membrane potential signal, yet completely abolished internalisation as expected. In contrast heterologous desensitisation was deeply compromised in some mutants of the ICL3 while total phosphorylation deletion of the C-terminal was the only variant to increase desensitisation of somatostatin signalling. Interestingly buprenorphine induced signalling had a quite different profile across the variants, and morphine and methodone signalling were more affected by the ICL3 changes when compared to opioid peptides and buprenorphine.

Overall, these results support the hypothesis of multiple mechanisms involved in regulation of MOPr, where ICL2 and ICL3 are crucial for G protein signalling, and receptor phosphorylation is not necessary for receptor desensitisation. In addition,…

Advisors/Committee Members: Macquarie University. Department of Biomedical Sciences.

Subjects/Keywords: Opioids – Receptors; opioid; polymorphism; desensitization

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Junqueira Santiago, M. (2015). Regulation of the μ-opioid receptor signalling in naturally occurring variants and phosphorylation site mutants. (Doctoral Dissertation). Macquarie University. Retrieved from http://hdl.handle.net/1959.14/1068731

Chicago Manual of Style (16^th Edition):

Junqueira Santiago, Marina. “Regulation of the μ-opioid receptor signalling in naturally occurring variants and phosphorylation site mutants.” 2015. Doctoral Dissertation, Macquarie University. Accessed February 27, 2021. http://hdl.handle.net/1959.14/1068731.

MLA Handbook (7^th Edition):

Junqueira Santiago, Marina. “Regulation of the μ-opioid receptor signalling in naturally occurring variants and phosphorylation site mutants.” 2015. Web. 27 Feb 2021.

Vancouver:

Junqueira Santiago M. Regulation of the μ-opioid receptor signalling in naturally occurring variants and phosphorylation site mutants. [Internet] [Doctoral dissertation]. Macquarie University; 2015. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/1959.14/1068731.

Council of Science Editors:

Junqueira Santiago M. Regulation of the μ-opioid receptor signalling in naturally occurring variants and phosphorylation site mutants. [Doctoral Dissertation]. Macquarie University; 2015. Available from: http://hdl.handle.net/1959.14/1068731

Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

11. Dimitriadou, Meropi. Συσχέτιση του γονιδιακού πολυμορφισμού Fok-I του υποδοχέα της βιταμίνης D με απεικονιστικές και βιοχημικές παραμέτρους οστικού μεταβολισμού σε παιδιά και νεαρούς ενήλικες με ομόζυγη β-μεσογειακή αναιμία.

Degree: 2015, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

URL: http://hdl.handle.net/10442/hedi/35698

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In recent years the genetic contribution on osteoporosis has been studied thoroughtly with the presence of various gene polymorphisms. We sought to estimate the degree… (more)

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In recent years the genetic contribution on osteoporosis has been studied thoroughtly with the presence of various gene polymorphisms. We sought to estimate the degree of genetic contribution of Fok-I gene polymorphism of Vitamin D Receptor (VDR) to the evolution of bone mass in patients with β-TM assessed with imaging techniques and biochemical parameters of bone metabolism over a period of two years. Sixty-four children and young adults (33 males and 31 females) with mean decimal age of 23.20 ± 5.41 (range: 9.25-32.41 years) were recruited in this study. All patients were genotyped for Fok-I gene polymorphism using the method of Polymerase Chain Reaction (PCR). Bone mass was assessed with both Dual energy X-ray Absorptiometry (DXA) and Quantitative Ultrasound Sonography (QUS) at baseline and two years after. Z-scores were calculated based on normal age and sex matched Caucasian population. Metabolites of vitamin D, intact PTH, total calcium, inorganic phosphorous and alkaline phosphatase were measured at serum with the specimen collected before regular transfusions. Twentynine patients were homozygous for the F allele (FF, 45.3%), twentyseven patients were heterozygotes (Ff, 42.2%) and eight patients were homozygous for the f allele (ff, 12.5%). A significant proportion of patients (15.6%) showed decreased values of DXA measured at lumbar spine (Z-score ≤ -2) at baseline and especially at the hip (31%). Α statistically significant deterioration in both sexes was observed in DXA measurements both at the femoral neck (p <0,001) and at the hip (p <0,001). A very small percentage of patients showed abnormally low SOS values measured in radius (7.8%) and only 1 patient at tibia at the beginning of the study. All patients had normal SOS values in the re-evaluation. With regards to genotyping, no deviation was observed with respect to DXA measurements, although carriers of the f allele in homozygosity clearly had better measurements compared with F carriers either in homo- or hetero-zygosity. However in retesting, DXA values at femoral neck (FF: p = 0,004 Ff: p <0,001, ff: p = 0,024) and at total hip (FF: p = 0,022, Ff: p = 0,005) deteriorated significantly in all genotypes except for ff and with regards to measurements at total hip. This finding was not replicated with regards to QUS measurements. The vast majority of patients showed insufficient (59.4%) and borderline (12.5 %) levels of vitamin D. In conclusion, the f allele in homozygosity seems to have a positive impact on evolution of bone disease in patients with b-MA. The level of agreement between the two imaging methods for identifying patients with low bone properties was poor.

Τελευταία, μελετάται η επίδραση διάφορων γονιδιακών πολυμορφισμών στην αιτιοπαθογένεια της οστικής νόσου σε ασθενείς με ομόζυγη β-ΜΑ. Σκοπός της μελέτης ήταν η διερεύνηση της επίδρασης του γονιδιακού πολυμορφισμού Fok-I του υποδοχέα της βιταμίνης D στην οστική κατάσταση παιδιών και νεαρών ενηλίκων με β-ΜΑ, όπως εκτιμήθηκε με απεικονιστικές και βιοχημικές παραμέτρους οστικού…

Subjects/Keywords: Γονιδιακός πολυμορφισμός; Gene polymorphism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dimitriadou, M. (2015). Συσχέτιση του γονιδιακού πολυμορφισμού Fok-I του υποδοχέα της βιταμίνης D με απεικονιστικές και βιοχημικές παραμέτρους οστικού μεταβολισμού σε παιδιά και νεαρούς ενήλικες με ομόζυγη β-μεσογειακή αναιμία. (Thesis). Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Retrieved from http://hdl.handle.net/10442/hedi/35698

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dimitriadou, Meropi. “Συσχέτιση του γονιδιακού πολυμορφισμού Fok-I του υποδοχέα της βιταμίνης D με απεικονιστικές και βιοχημικές παραμέτρους οστικού μεταβολισμού σε παιδιά και νεαρούς ενήλικες με ομόζυγη β-μεσογειακή αναιμία.” 2015. Thesis, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Accessed February 27, 2021. http://hdl.handle.net/10442/hedi/35698.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dimitriadou, Meropi. “Συσχέτιση του γονιδιακού πολυμορφισμού Fok-I του υποδοχέα της βιταμίνης D με απεικονιστικές και βιοχημικές παραμέτρους οστικού μεταβολισμού σε παιδιά και νεαρούς ενήλικες με ομόζυγη β-μεσογειακή αναιμία.” 2015. Web. 27 Feb 2021.

Vancouver:

Dimitriadou M. Συσχέτιση του γονιδιακού πολυμορφισμού Fok-I του υποδοχέα της βιταμίνης D με απεικονιστικές και βιοχημικές παραμέτρους οστικού μεταβολισμού σε παιδιά και νεαρούς ενήλικες με ομόζυγη β-μεσογειακή αναιμία. [Internet] [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2015. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10442/hedi/35698.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dimitriadou M. Συσχέτιση του γονιδιακού πολυμορφισμού Fok-I του υποδοχέα της βιταμίνης D με απεικονιστικές και βιοχημικές παραμέτρους οστικού μεταβολισμού σε παιδιά και νεαρούς ενήλικες με ομόζυγη β-μεσογειακή αναιμία. [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2015. Available from: http://hdl.handle.net/10442/hedi/35698

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Georgia

12. Gatlin, Michael Richard. Cytokine gene polymorphisms associated with resistance vs. susceptibility to reinfection with Schistosoma mansoni.

Degree: 2014, University of Georgia

URL: http://hdl.handle.net/10724/25451

► The immunologic findings that most consistently correlate with resistance in human schistosomiasis are high levels of IgE and low levels of IgG4. We have genotyped… (more)

▼ The immunologic findings that most consistently correlate with resistance in human schistosomiasis are high levels of IgE and low levels of IgG4. We have genotyped gene and promoter polymorphisms of cytokines associated with regulation of these isotypes in a cohort of men occupationally exposed to Schistosoma mansoni in western Kenya and evaluated their patterns with respect to resistance and susceptibility to reinfection after treatment and cure with praziquantel (PZQ). In this cohort, polymorphisms in IL-4 (−590T high IgE), IL-13 (−1055T high producer) and IFN-γ (+874A high producer) demonstrated several correlations with resistance to reinfection. Resistance to reinfection was significantly correlated with the heterozygous IL-4 −590 genotype C/T (OR 3.5, [CI 1.2, 10.2]) compared to T/T. Among men with a homozygous IL-13 genotype CC/TT, having a T allele at the IFN- +874 position increased the odds of resistance relative to individuals with the IFN- +874 A/A genotype (OR=17.5 [CI 3.0, 101.5]). Among men with homozygous A/A IFN- genotype, the heterozygous IL-13 genotype C/T was associated with resistance relative to the homozygous C/C or T/T genotypes (OR=22.5 [CI 3.5, 144.4]). No increases in odds of resistance were found in relation to the IL-13 genotype among those with a T allele in the IFN- gene or in relation to the IFN- genotype among those with a heterozygous IL-13 genotype. Calculation of the attributable proportion of resistance showed a significant synergistic interaction between IL-13 −1055 C/T and IL-4 −590 C/T. The identified polymorphisms do not by themselves confer resistance or susceptibility, but we propose that these genotypes allow the resistant phenotype to be developed and expressed upon suitable immune exposure. Based on the literature, these polymorphisms contribute to the regulation of their respective cytokines, likely leading to downstream differences in the production and interrelationships of critical defense mechanisms.

Subjects/Keywords: Schistosoma mansoni; polymorphism; resistance; cytokine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gatlin, M. R. (2014). Cytokine gene polymorphisms associated with resistance vs. susceptibility to reinfection with Schistosoma mansoni. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/25451

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gatlin, Michael Richard. “Cytokine gene polymorphisms associated with resistance vs. susceptibility to reinfection with Schistosoma mansoni.” 2014. Thesis, University of Georgia. Accessed February 27, 2021. http://hdl.handle.net/10724/25451.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gatlin, Michael Richard. “Cytokine gene polymorphisms associated with resistance vs. susceptibility to reinfection with Schistosoma mansoni.” 2014. Web. 27 Feb 2021.

Vancouver:

Gatlin MR. Cytokine gene polymorphisms associated with resistance vs. susceptibility to reinfection with Schistosoma mansoni. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10724/25451.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gatlin MR. Cytokine gene polymorphisms associated with resistance vs. susceptibility to reinfection with Schistosoma mansoni. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/25451

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brigham Young University

13. Perry, Cynthia Elizabeth. Association Between Polymorphisms Associated with Major Depression, Cognitive Function, and Stress Regulation and Telomere Length in Older Community-Dwelling Adults and in Older Competitive Athletes.

Degree: MS, 2016, Brigham Young University

URL: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7214&context=etd

► Many factors detrimental to healthy aging have been proposed including depression, stress, cognitive decline, and telomere shortening. Of specific interest are the genetic factors that… (more)

▼ Many factors detrimental to healthy aging have been proposed including depression, stress, cognitive decline, and telomere shortening. Of specific interest are the genetic factors that may contribute to these factors and subsequently lead to accelerated telomere shortening and aging, namely the Bcl1, 5-HT, DRD2, and ApoE polymorphisms. We sought to: 1) further clarify the role of depression, stress tolerance, and cognitive decline in aging by examining the effect of associated polymorphisms (Bcl1, 5-HT, DRD2, and ApoE) on telomere length in two samples of older adults and 2) determine the difference in absolute telomere length between the two groups. We examined two samples of older adults: participants in a competitive, athletic event (N=220; mean age=66.8 years) and a sample of community-dwelling older adults (N=208; mean age=69.1 years). Participants completed a questionnaire with demographic information and provided a saliva sample. The Bcl1, 5-HT, DRD2, and ApoE polymorphisms were determined using PCR and Taqman assays. Telomere length was determined using qPCR analysis. The community-dwelling group had significantly shorter telomere lengths than the athletic group (t=-4.82, p< .0001). Additionally, for males in the athletic group, the L/S genotype of the 5-HT polymorphism was associated with longer telomere length. In males in the community-dwelling group, the GC genotype of the Bcl1 polymorphism was associated with shorter telomere length. In females in the athletic group, the GC and GG genotypes of the Bcl1 polymorphism were associated with shorter telomere length with the opposite being true for females in the community-dwelling group: the GC genotype of the Bcl1 polymorphism predicted longer telomere length. Exercising nearly everyday and the length of exercise were associated with telomere length in both groups. Our results indicate that competitive athletic activity in older age is associated with increased telomere length, longer periods of exercise at one time may contribute to longer telomere length, and the Bcl1 and 5-HT polymorphisms are associated with telomere length in older adults.

Subjects/Keywords: Telomeres; healthy aging; Bcl1 polymorphism; 5-HT polymorphism; exercise; Psychology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Perry, C. E. (2016). Association Between Polymorphisms Associated with Major Depression, Cognitive Function, and Stress Regulation and Telomere Length in Older Community-Dwelling Adults and in Older Competitive Athletes. (Masters Thesis). Brigham Young University. Retrieved from https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7214&context=etd

Chicago Manual of Style (16^th Edition):

Perry, Cynthia Elizabeth. “Association Between Polymorphisms Associated with Major Depression, Cognitive Function, and Stress Regulation and Telomere Length in Older Community-Dwelling Adults and in Older Competitive Athletes.” 2016. Masters Thesis, Brigham Young University. Accessed February 27, 2021. https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7214&context=etd.

MLA Handbook (7^th Edition):

Perry, Cynthia Elizabeth. “Association Between Polymorphisms Associated with Major Depression, Cognitive Function, and Stress Regulation and Telomere Length in Older Community-Dwelling Adults and in Older Competitive Athletes.” 2016. Web. 27 Feb 2021.

Vancouver:

Perry CE. Association Between Polymorphisms Associated with Major Depression, Cognitive Function, and Stress Regulation and Telomere Length in Older Community-Dwelling Adults and in Older Competitive Athletes. [Internet] [Masters thesis]. Brigham Young University; 2016. [cited 2021 Feb 27]. Available from: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7214&context=etd.

Council of Science Editors:

Perry CE. Association Between Polymorphisms Associated with Major Depression, Cognitive Function, and Stress Regulation and Telomere Length in Older Community-Dwelling Adults and in Older Competitive Athletes. [Masters Thesis]. Brigham Young University; 2016. Available from: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7214&context=etd

Univerzitet u Beogradu

14. Pantelić, Jelica R., 1970-. Ispitivanje polimorfizama eNOS gena kao faktora rizika za razvoj retinopatije prevremeno rođene dece.

Degree: Medicinski fakultet, 2017, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:14296/bdef:Content/get

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Oftalmologija - humana genetika / ophthalmology - human genetics

Uvod: Retinopatija prematuriteta (ROP) je oboljenje mrežnjače oka prevremeno roñene dece i osnovni je uzrok teškog… (more)

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Oftalmologija - humana genetika / ophthalmology - human genetics

Uvod: Retinopatija prematuriteta (ROP) je oboljenje mrežnjače oka prevremeno roñene dece i osnovni je uzrok teškog oštenja vida u detinjstvu. Genetička istraživanja ROP usmerena su ka otkrivanju varijanti gena odgovornih za razvoj teških formi ROP-a. Cilj ove studije bio je da ispita učestalost genotipova i alela polimorfizama T-786C i 4a/4b gena za endotelnu azot oksid sintetazu (eNOS) u populaciji prevremeno roñene dece kao i povezanost ispitivanih polimorfnih varijanti sa nastankom teškog stepena retinopatije. Takoñe, cilj ove studije je ispitivanje kliničkih faktora rizika udruženih sa nastankom teškog stepena ROP-a. Metodologija: Istraživanje je uključilo 239 prevremeno roñene dece. Na osnovu sprovedenog oftalmološkog skrininga prevremeno roñena deca su podeljena u dve grupe. ROP grupa je obuhvatila 113 dece kod kojih je stepen ROP-a zahtevao oftalmološku terapiju, a kontrolnu grupu činilo je 126 dece bez terapije. DNK je izolovana iz brisa bukalne sluznice prevremeno roñene dece a ispitivanje polimorfizama vršeno je PCR metodom. Rezultati: Ispitivanje polimorfizma T-786C pokazalo je da je 39,1% dece homozigotno za češći alel T (genotip TT), 52,3% su heterozigoti (genotip CT) i 8,6% homozigoti za reñi alel C (genotip CC). Učestalost C alela je 34,8%. Učestalost genotipova T-786C polimorfizma u grupi sa ROP-om je: 40,0% TT genotipa, 51,7% CT genotipa i CC genotipa 8,3%. U kontrolnoj grupi učestalost TT genotipa je 38,2%, CT genotipa 52,9% i CC genotipa 8,8%. Učestalost C alela u ROP grupi je 34,2%, a 35,3% u kontrolnoj grupi. Ispitivanjem polimorfizma 4a/4b utvrñeno je da je 65,3% dece homozigotno za češći alel 4b (genotip bb), 31,2% su heterozigoti (genotip ab) i 3,5% homozigoti za reñi alel 4a (genotip aa). Učestalost 4a alela je 19,1%. Učestalost 4a/4b polimorfizma u grupi sa ROP-om je: genotipa 4bb 60,2%, genotipa 4ba 34,9% i 4aa genotipa 4,9%. U kontrolnoj grupi učestalost genotipa 4bb je 70,1%, genotipa 4ba 27,6% i 4aa genotipa 2,3%. Učestalost 4a alela u ROP grupi je 22,3%, a 16,1% u kontrolnoj grupi...

Advisors/Committee Members: Stefanović, Ivan, 1964-.

Subjects/Keywords: Retinopathy of prematurity; T-786C polymorphism; 4a/b polymorphism; eNOS gene

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pantelić, Jelica R., 1. (2017). Ispitivanje polimorfizama eNOS gena kao faktora rizika za razvoj retinopatije prevremeno rođene dece. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:14296/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pantelić, Jelica R., 1970-. “Ispitivanje polimorfizama eNOS gena kao faktora rizika za razvoj retinopatije prevremeno rođene dece.” 2017. Thesis, Univerzitet u Beogradu. Accessed February 27, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:14296/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pantelić, Jelica R., 1970-. “Ispitivanje polimorfizama eNOS gena kao faktora rizika za razvoj retinopatije prevremeno rođene dece.” 2017. Web. 27 Feb 2021.

Vancouver:

Pantelić, Jelica R. 1. Ispitivanje polimorfizama eNOS gena kao faktora rizika za razvoj retinopatije prevremeno rođene dece. [Internet] [Thesis]. Univerzitet u Beogradu; 2017. [cited 2021 Feb 27]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:14296/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pantelić, Jelica R. 1. Ispitivanje polimorfizama eNOS gena kao faktora rizika za razvoj retinopatije prevremeno rođene dece. [Thesis]. Univerzitet u Beogradu; 2017. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:14296/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Shepherd, Jimmie G. Crystalline Polymorphism of Nitrates.

Degree: 1951, North Texas State College

URL: https://digital.library.unt.edu/ark:/67531/metadc97053/

► The purpose of this study was to investigate the polymorphism of a group of related compounds. Special emphasis was placed upon the temperature at which… (more)

Subjects/Keywords: crystalline polymorphism; Polymorphism (Crystallography); Nitrates.

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APA (6^th Edition):

Shepherd, J. G. (1951). Crystalline Polymorphism of Nitrates. (Thesis). North Texas State College. Retrieved from https://digital.library.unt.edu/ark:/67531/metadc97053/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shepherd, Jimmie G. “Crystalline Polymorphism of Nitrates.” 1951. Thesis, North Texas State College. Accessed February 27, 2021. https://digital.library.unt.edu/ark:/67531/metadc97053/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shepherd, Jimmie G. “Crystalline Polymorphism of Nitrates.” 1951. Web. 27 Feb 2021.

Vancouver:

Shepherd JG. Crystalline Polymorphism of Nitrates. [Internet] [Thesis]. North Texas State College; 1951. [cited 2021 Feb 27]. Available from: https://digital.library.unt.edu/ark:/67531/metadc97053/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shepherd JG. Crystalline Polymorphism of Nitrates. [Thesis]. North Texas State College; 1951. Available from: https://digital.library.unt.edu/ark:/67531/metadc97053/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Leiden University

16. Verschuur, M. Functional aspects of fibrinogen B and plasminogen activator inhibitor-1 promoter variants.

Degree: 2005, Leiden University

URL: http://hdl.handle.net/1887/615

Subjects/Keywords: Fibrinogen; Polymorphism; Fibrinogen; Polymorphism

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APA (6^th Edition):

Verschuur, M. (2005). Functional aspects of fibrinogen B and plasminogen activator inhibitor-1 promoter variants. (Doctoral Dissertation). Leiden University. Retrieved from http://hdl.handle.net/1887/615

Chicago Manual of Style (16^th Edition):

Verschuur, M. “Functional aspects of fibrinogen B and plasminogen activator inhibitor-1 promoter variants.” 2005. Doctoral Dissertation, Leiden University. Accessed February 27, 2021. http://hdl.handle.net/1887/615.

MLA Handbook (7^th Edition):

Verschuur, M. “Functional aspects of fibrinogen B and plasminogen activator inhibitor-1 promoter variants.” 2005. Web. 27 Feb 2021.

Vancouver:

Verschuur M. Functional aspects of fibrinogen B and plasminogen activator inhibitor-1 promoter variants. [Internet] [Doctoral dissertation]. Leiden University; 2005. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/1887/615.

Council of Science Editors:

Verschuur M. Functional aspects of fibrinogen B and plasminogen activator inhibitor-1 promoter variants. [Doctoral Dissertation]. Leiden University; 2005. Available from: http://hdl.handle.net/1887/615

Univerzitet u Beogradu

17. Varljen, Tatjana, 1973- 30806375. Ispitivanje učestalosti polimorfizama gena za faktor nekroze tumora [alfa], interleukin 6 i interleukin 1[beta] kod prevremeno rođene dece kao faktor rizika za nastanak sepse.

Degree: Medicinski fakultet, 2019, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:20534/bdef:Content/get

►

Medicina - Molekularna medicina / Medicine - Molecular medicine

Neonatalna sepsa predstavlja vodeći uzrok morbiditeta i mortaliteta kod prevremeno rođene dece. Genetički faktori mogu uticati… (more)

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Medicina - Molekularna medicina / Medicine - Molecular medicine

Neonatalna sepsa predstavlja vodeći uzrok morbiditeta i mortaliteta kod prevremeno rođene dece. Genetički faktori mogu uticati na nastanak, tok i ishod rane neonatalne sepse. Cilj našeg istraživanja bio je da ispitamo povezanost TNFα -308 G/A, IL6 -174 G/C i IL1β -511 G/A polimorfizama sa nastankom i ishodom rane neonatalne sepse kod prematurusa. Istraživanje je obuhvatilo 471 prevremeno rođeno dete, 282 sa sepsom (151 hemokulturom potvrđenom i 131 kliničkom sepsom) i 189 bez sepse koji su činili kontrolnu grupu. Učestalost alela A i AA genotipa TNFα -308 G/A polimorfizma je statistički značajno veća kod prematurusa sa sepsom u odnosu na prematuruse kontrolne grupe. GA+AA genotipovi polimorfizma TNFα -308 G/A su statistički značajno povezani sa nastankom hemokulturom potvrđene sepse i kliničke sepse. Učestalost AA genotipa IL1β -511 G/A polimorfizma statistički je značajno veća u grupi prematurusa sa hemokulturom potvrđenom sepsom i kliničkom sepsom u odnosu na kontrolnu grupu. Takođe, AA genotip IL1β -511 G/A polimorfizma udružen je sa letalnim ishodom od sepse kod prematurusa. Logistička regresiona analiza sa gestacijskom starošću, porođajnom telesnom masom i Apgar skorom u ’5 kao kovarijatama potvrdila je statistički značajnu povezanost geneotipova GA+AA TNFα -308 G/A i AA IL1β -511 G/A polimorfizma sa nastankom sepse. U našoj studiji nema statistički značajne razlike u učestalosti alela i genotipova IL6 -174 G/C polimorfizma između grupa prematurusa sa hemokulturom potvrđenom, kliničkom sepsom i kontrolne grupe prematurusa. Rezultati naše studije pokazuju da su alel A i AA genotip TNFα -308 G/A i AA genotip IL1β -511 G/A polimorfizma faktori rizika za razvoj rane neonatalne sepse. Genotip AA IL1β -511 G/A polimorfizma je faktor rizika za smrtni ishod od rane neonatalne sepse prematurusa.

Advisors/Committee Members: Damjanović, Tatjana, 1964- 29979751.

Subjects/Keywords: TNFα -308 G/A polymorphism; IL6 -174 G/C polymorphism; IL1β -511 G/A polymorphism; early onset sepsis; lethal outcome

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Varljen, Tatjana, 1. 3. (2019). Ispitivanje učestalosti polimorfizama gena za faktor nekroze tumora [alfa], interleukin 6 i interleukin 1[beta] kod prevremeno rođene dece kao faktor rizika za nastanak sepse. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:20534/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Varljen, Tatjana, 1973- 30806375. “Ispitivanje učestalosti polimorfizama gena za faktor nekroze tumora [alfa], interleukin 6 i interleukin 1[beta] kod prevremeno rođene dece kao faktor rizika za nastanak sepse.” 2019. Thesis, Univerzitet u Beogradu. Accessed February 27, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:20534/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Varljen, Tatjana, 1973- 30806375. “Ispitivanje učestalosti polimorfizama gena za faktor nekroze tumora [alfa], interleukin 6 i interleukin 1[beta] kod prevremeno rođene dece kao faktor rizika za nastanak sepse.” 2019. Web. 27 Feb 2021.

Vancouver:

Varljen, Tatjana 13. Ispitivanje učestalosti polimorfizama gena za faktor nekroze tumora [alfa], interleukin 6 i interleukin 1[beta] kod prevremeno rođene dece kao faktor rizika za nastanak sepse. [Internet] [Thesis]. Univerzitet u Beogradu; 2019. [cited 2021 Feb 27]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:20534/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Varljen, Tatjana 13. Ispitivanje učestalosti polimorfizama gena za faktor nekroze tumora [alfa], interleukin 6 i interleukin 1[beta] kod prevremeno rođene dece kao faktor rizika za nastanak sepse. [Thesis]. Univerzitet u Beogradu; 2019. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:20534/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

North-West University

18. Mbongwa, Hlengiwe Prosperity. Characterisation of the SULT1A1 polymorphism in a South African Tswana population group / y Hlengiwe P. Mbongwa.

Degree: 2010, North-West University

URL: http://hdl.handle.net/10394/4225

► This dissertation brings to the fore the “Characterization of the SULT1A1 polymorphism in a South Africa Tswana population group.” The primary experimental group studied came… (more)

▼ This dissertation brings to the fore the “Characterization of the SULT1A1 polymorphism in a South Africa Tswana population group.” The primary experimental group studied came from South African homogeneous Tswana individuals who participated voluntarily in an ongoing large-scale epidemiological Prospective Urban and Rural Epidemiological (PURE) study the North-West University (Potchefstroom Campus) participates in, as one of the 16 low- middleand high-income countries across the world. The primary aspect investigated was the comprehensive profile of the single nucleotide polymorphism (SNP) and copy number variation (CNP) of the SULT1A1 gene. Using the PCRbased RFLP method, SULT1A1 genotypes, and allele frequency distributions in an experimental group of 1 867 individuals were determined. According to the literature this is by far the largest and most homogeneous group from which such information has been acquired to date. The SULT1A1*1, SULT1A1*1/*2 and SULT1A1*2 genotypes were found to be present at a percentage of 43.76, 47.12 and 9.11 respectively. In comparison to similar studies in other population groups, results from this study indicate that there are ethnic differences in the SULT1A1 genotypes incidence. Asian group differs from Caucasian and Tswana groups because of its exceptionally high prevalence of individuals with the SULT1A1*1 genotype and a very low incidence of the SULT1A1*2 genotype. The SULT1A1*1 genotype profiles of Caucasian and Tswana groups were comparable, but notable differences were observed for the SULT1A1*2 genotype. Using a quantitative multiplex PCR method for the CNV study, the numbers of copies of the SULT1A1 gene in the Tswana population were determined, and the results showed 1 to ~5 copies: only 0.65% of the subjects had a single copy, whereas 59.69% of the subjects had 3 or more copies. This result shows a significant discrepancy between the Caucasian-American samples, which showed that only 26% from that group had more than three copies. However, there is a significant relationship with the African-American population, which presented 63% with 3 or more copies. This finding confirms results from a much smaller African-American study, and suggests a possible genetic link between the African Tswana and the heritage of the African-Americans. These findings were submitted for publication to the South African Journal of Science, as that journal specializes in publication of new knowledge that has a regional focus on Africa. Simultaneous phenotypic consequences of the SNP and CNP of the SULT1A1 gene, as well as the thermo-stable and thermo-labile forms of the sulfotransferases were determined. For this, the formation of [35S]-4-nitrophenyl sulphate from 4-nitrophenol and [35S]-3’-phosphoadenosine- 5’-phosphosulfate ([35S]-PAPS) in platelet homogenates were measured, with the data normalized to a common platelet count. This investigation required fresh blood for enzyme activity. These samples came from 98 Caucasian subjects who voluntarily participated in this part of the study. The…

Subjects/Keywords: PURE study; South African Tswana population; Copy number polymorphism; Single nucleotide polymorphism; SULT1A1 polymorphism; Sulfotransferases; Targeted metabolomics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mbongwa, H. P. (2010). Characterisation of the SULT1A1 polymorphism in a South African Tswana population group / y Hlengiwe P. Mbongwa. (Thesis). North-West University. Retrieved from http://hdl.handle.net/10394/4225

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mbongwa, Hlengiwe Prosperity. “Characterisation of the SULT1A1 polymorphism in a South African Tswana population group / y Hlengiwe P. Mbongwa. ” 2010. Thesis, North-West University. Accessed February 27, 2021. http://hdl.handle.net/10394/4225.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mbongwa, Hlengiwe Prosperity. “Characterisation of the SULT1A1 polymorphism in a South African Tswana population group / y Hlengiwe P. Mbongwa. ” 2010. Web. 27 Feb 2021.

Vancouver:

Mbongwa HP. Characterisation of the SULT1A1 polymorphism in a South African Tswana population group / y Hlengiwe P. Mbongwa. [Internet] [Thesis]. North-West University; 2010. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10394/4225.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mbongwa HP. Characterisation of the SULT1A1 polymorphism in a South African Tswana population group / y Hlengiwe P. Mbongwa. [Thesis]. North-West University; 2010. Available from: http://hdl.handle.net/10394/4225

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

19. Lee, Bi-yao. Investigations of The Effects of Glucocorticoid Receptor SNPs and SUMO-2 Autoantibody in Patients with Systemic Lupus Erythematosus.

Degree: Master, Institute of Biomedical Sciences, 2008, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0730108-135015

► For more than fifty years glucocorticoids (GCs) has been used to treat a wide range of inflammatory diseases, such as allergies, asthma, rheumatoid arthritis, and… (more)

Subjects/Keywords: polymorphism; SUMO-2; glucocorticoid receptor; SLE

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APA (6^th Edition):

Lee, B. (2008). Investigations of The Effects of Glucocorticoid Receptor SNPs and SUMO-2 Autoantibody in Patients with Systemic Lupus Erythematosus. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0730108-135015

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lee, Bi-yao. “Investigations of The Effects of Glucocorticoid Receptor SNPs and SUMO-2 Autoantibody in Patients with Systemic Lupus Erythematosus.” 2008. Thesis, NSYSU. Accessed February 27, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0730108-135015.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lee, Bi-yao. “Investigations of The Effects of Glucocorticoid Receptor SNPs and SUMO-2 Autoantibody in Patients with Systemic Lupus Erythematosus.” 2008. Web. 27 Feb 2021.

Vancouver:

Lee B. Investigations of The Effects of Glucocorticoid Receptor SNPs and SUMO-2 Autoantibody in Patients with Systemic Lupus Erythematosus. [Internet] [Thesis]. NSYSU; 2008. [cited 2021 Feb 27]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0730108-135015.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lee B. Investigations of The Effects of Glucocorticoid Receptor SNPs and SUMO-2 Autoantibody in Patients with Systemic Lupus Erythematosus. [Thesis]. NSYSU; 2008. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0730108-135015

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

20. Ming Yen, Liang. The Association of XRCC1 Polymorphisms with Development and Prognosis of Oral and Pharyngeal Squamous Cell Carcinomas.

Degree: Master, Biological Sciences, 2011, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0825111-020128

► X-ray repair cross complementing Group 1 (XRCC1) protein plays an important role in base excision repair. Single nucleotide polymorphisms (SNPs) in XRCC1 gene may affect… (more)

▼ X-ray repair cross complementing Group 1 (XRCC1) protein plays an important role in base excision repair. Single nucleotide polymorphisms (SNPs) in XRCC1 gene may affect DNA repairing ability, genetic susceptibility, and prognosis to oral and pharyngeal squamous cell cancer (OPSCC). This study was carried out to evaluate the association of three XRCC1 SNPs with the risk and prognosis of OPSCC. A total of 509 OPSCC cases and 678 cancer-free controls were recruited to detect the genotypes of XRCC1 by PCR-RFLP. Then, 447 case patients with surgical treatment and safety margins were included in the survival analysis. No association was observed for XRCC1 194 and the risk of OPSCC. As compared with the wild Arg/Arg genotype, the combined genotypes of 280 Arg/His and His/His were with decreased risk (AOR=0.73, 95% CI, 0.52-1.03, p = 0.069) of OPSCC and with a significantly decreased risk (AOR=0.67, 95% CI, 0.47-0.97, p = 0.035) of oral cavity. As compared with the Arg/Arg genotype of XRCC1 399, the Gln/Gln genotype was with the increased risk of OPSCC (AOR=2.06, 95%CI: 1.21-3.51, p = 0.008) and oral cavity cancer (AOR=1.89, 95%CI: 1.08-3.33, p = 0.026). We defined the âputative high risk haplotypesâ as âArg-Arg-Gln and Trp-Arg-Glnâ. The AOR were 1.29 (95% CI, 1.04-1.60, p = 0.020) for the âputative high risk haplotypesâ as compared with other haplotypes for OPSCC. Then, two putative high risk haplotypes were combined into âputative high risk diplotypesâ. The AOR for the âhigh risk diplotypesâ were 1.98 (95% CI, 1.18-3.33, p = 0.010) as compared with other diplotypes for OPSCC. No association between XRCC1 polymorphisms and clinicopathological outcomes, except XRCC1 280. Those carriers of XRCC1 280His allele (combined Arg/His and His/His genotypes) were associated with late onset (≥50 yrs) of oral cavity cancers. No association between genetic variants in XRCC1 and disease-specific survival except XRCC1 399. Patients with 399 Arg/Gln and Gln/Gln genotypes showed a significant better survival as compared to Arg/Arg genotype carriers (AHR 0.41 95% CI: 0.18-0.93), especially for those patients younger than 50 years (p = 0.012), in pathological stage III or IV (p = 0.044), and without postoperative radiotherapy (p = 0.012). In summary, XRCC1 280 Arg/His and His/His genotypes were associated with decreased risk of oral cavity cancer. 399 Gln/Gln genotype was associated with increased risk of OPSCC and oral cavity cancer. The putative âhigh risk haplotypes and diplotypesâ were with increased risk of OPSCC. However, 399 Arg/Gln and Gln/Gln genotypes were prognostic factors, especially for those with young age, aggressive tumor stage, and without postoperative radiotherapy for oro and hypopharynx patients. These findings suggest that XRCC1 polymorphisms may play a role in the development and prognosis of OPSCC. Advisors/Committee Members: Shiue, Yow-Ling (chair), Cho, Chung-Lung (chair), Cheng, Jiin-Tsuey (committee member), Luo-Ping Ger (committee member).

Subjects/Keywords: prognosis; polymorphism; XRCC1; risk; OPSCC; oral cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ming Yen, L. (2011). The Association of XRCC1 Polymorphisms with Development and Prognosis of Oral and Pharyngeal Squamous Cell Carcinomas. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0825111-020128

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ming Yen, Liang. “The Association of XRCC1 Polymorphisms with Development and Prognosis of Oral and Pharyngeal Squamous Cell Carcinomas.” 2011. Thesis, NSYSU. Accessed February 27, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0825111-020128.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ming Yen, Liang. “The Association of XRCC1 Polymorphisms with Development and Prognosis of Oral and Pharyngeal Squamous Cell Carcinomas.” 2011. Web. 27 Feb 2021.

Vancouver:

Ming Yen L. The Association of XRCC1 Polymorphisms with Development and Prognosis of Oral and Pharyngeal Squamous Cell Carcinomas. [Internet] [Thesis]. NSYSU; 2011. [cited 2021 Feb 27]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0825111-020128.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ming Yen L. The Association of XRCC1 Polymorphisms with Development and Prognosis of Oral and Pharyngeal Squamous Cell Carcinomas. [Thesis]. NSYSU; 2011. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0825111-020128

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. Ana Maria Bezerra Oliveira LÃbo. Estudo genÃtico de caracterÃsticas de importÃncia econÃmica em uma populaÃÃo multirracial de ovinos de corte: uma abordagem quantitativa e molecular .

Degree: Master, 2008, Universidade Federal do Ceará

URL: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4317 ;

► Atualmente, existe uma grande possibilidade de associaÃÃo entre as Ãreas de genÃtica quantitativa e de genÃtica molecular. Isto pode causar importante impacto na seleÃÃo de… (more)

▼ Atualmente, existe uma grande possibilidade de associaÃÃo entre as Ãreas de genÃtica quantitativa e de genÃtica molecular. Isto pode causar importante impacto na seleÃÃo de ovinos, com o estabelecimento de eficientes critÃrios de seleÃÃo para produÃÃo de carne. Com isso, os objetivos deste trabalho foram: verificar polimorfismos nos genes GDF9, Calpastatina e Aromatase (CYP19); verificar a freqÃÃncia de variantes alÃlicas do tipo SNP nestes genes; verificar os efeitos destas variantes sobre caracterÃsticas produtivas e reprodutivas de ovinos de uma populaÃÃo multirracial; estimar os parÃmetros genÃticos e os valores genÃticos destas caracterÃsticas, nesta populaÃÃo; verificar o efeito da inclusÃo do genÃtipo para estes genes nos modelos para estimativas de parÃmetros genÃticos e verificar o efeito do genÃtipo para estes genes sobre os valores genÃticos estimados. O gene GDF9 Ã um gene candidato relacionado com o fenÃtipo de alta prolificidade. O gene da Calpastatina possui importÃncia na produÃÃo de animais de corte, por estÃ relacionado ao crescimento e a qualidade da carne. O gene da aromatase Ã um candidato afetando o desempenho produtivo e reprodutivo, pelo seu importante papel no metabolismo dos hormÃnios esterÃides. O polimorfismo do tipo (SNP) do gene CYP19 foi investigado pela tÃcnica PCR-RFLP em uma amostra de 133 animais de diversos grupos genÃticos de ovinos de corte. Foram estimadas as freqÃÃncias alÃlicas e genotÃpicas de polimorfismos deste gene e investigado o efeito destas variantes sobre caracterÃsticas de crescimento, reprodutivas e de habilidade materna, utilizando o procedimento GLM do software SAS. As caracterÃsticas estudadas foram peso ao nascer (PN), peso ao desmame (PD), peso ao abate (PA), peso a um ano de idade (P1), ganho de peso mÃdio diÃrio do nascimento ao desmame (Gn_d), ganho de peso mÃdio diÃrio do desmame ao abate (Gdes_abat), ganho de peso mÃdio diÃrio do desmame a um ano de idade (Gdes_ano), idade ao primeiro parto (IPP), intervalo de partos (IP), perÃodo de gestaÃÃo (PG), dias para o parto (DP), peso total de crias nascidas por matriz por parto (PTCN) e peso total de crias desmamadas por matriz por parto (PTCD). ParÃmetros genÃticos e valores genÃticos foram estimados utilizando o mÃtodo da MÃxima VerossimilhanÃa Restrita Livre de Derivadas (DFREML). Foi avaliado o efeito da inclusÃo do genÃtipo para o gene da aromatase nos modelos para estimativas de parÃmetros genÃticos. Foi verificado o efeito do genÃtipo sobre os valores genÃticos estimados. NÃo foi possÃvel genotipar os animais para os genes GDF9 e Calpastatina, devido a dificuldades de padronizar as reaÃÃes. Assim, os animais foram genotipados apenas para o gene da aromatase. Na amostra estudada para o gene da aromatase, nÃo foram observados indivÃduos com genÃtipo AA. As freqÃÃncias para os genÃtipos AB e BB foram 0,65 e 0,35, respectivamente. A freqÃÃncia alÃlica diferiu entre os grupos genÃticos estudados. O gene da aromatase apresentou influÃncia sobre a maioria das caracterÃsticas estudadas, havendo diferenÃas no… Advisors/Committee Members: SÃnia Maria Pinheiro de Oliveira, Samuel Rezende Paiva, Raimundo Nonato Braga LÃbo.

Subjects/Keywords: ZOOTECNIA; Aromatase; Polimorfismo; SNP; Polymorphism; SNP

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

LÃbo, A. M. B. O. (2008). Estudo genÃtico de caracterÃsticas de importÃncia econÃmica em uma populaÃÃo multirracial de ovinos de corte: uma abordagem quantitativa e molecular . (Masters Thesis). Universidade Federal do Ceará. Retrieved from http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4317 ;

Chicago Manual of Style (16^th Edition):

LÃbo, Ana Maria Bezerra Oliveira. “Estudo genÃtico de caracterÃsticas de importÃncia econÃmica em uma populaÃÃo multirracial de ovinos de corte: uma abordagem quantitativa e molecular .” 2008. Masters Thesis, Universidade Federal do Ceará. Accessed February 27, 2021. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4317 ;.

MLA Handbook (7^th Edition):

LÃbo, Ana Maria Bezerra Oliveira. “Estudo genÃtico de caracterÃsticas de importÃncia econÃmica em uma populaÃÃo multirracial de ovinos de corte: uma abordagem quantitativa e molecular .” 2008. Web. 27 Feb 2021.

Vancouver:

LÃbo AMBO. Estudo genÃtico de caracterÃsticas de importÃncia econÃmica em uma populaÃÃo multirracial de ovinos de corte: uma abordagem quantitativa e molecular . [Internet] [Masters thesis]. Universidade Federal do Ceará 2008. [cited 2021 Feb 27]. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4317 ;.

Council of Science Editors:

LÃbo AMBO. Estudo genÃtico de caracterÃsticas de importÃncia econÃmica em uma populaÃÃo multirracial de ovinos de corte: uma abordagem quantitativa e molecular . [Masters Thesis]. Universidade Federal do Ceará 2008. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4317 ;

Universiteit Utrecht

22. Matovic, M. Investigation of binary solid phases by calorimetry and kinetic modelling.

Degree: 2007, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/21401

► The traditional methods for the determination of liquid-solid phase diagrams are based on the assumption that the overall equilibrium is established between the phases. However,… (more)

▼ The traditional methods for the determination of liquid-solid phase diagrams are based on the assumption that the overall equilibrium is established between the phases. However, the result of the crystallization of a liquid mixture will typically be a non-equilibrium or metastable state of the solid. For a proper description of the crystallization process the equilibrium approach is insufficient and a kinetic approach is actually required. In this work, we show that during slow crystallization of binary mixtures of 1,4-dichlorobenzene and 1,4-dibromobenzene, performed in an adiabatic calorimeter, it can be assumed that the liquid phase is in equilibrium only with the growing solid phase, i.e., the solid phase at the surface. The proposed kinetic model, based on the previous assumption, is extended to a method for the determination of the excess properties when the cooling path of the mixture is at disposal. Using these excess properties, the phase diagram is achieved, without adopting the approach of complete equilibrium between totally homogeneous phases. However, this method is appropriate only for slow crystallization and it cannot be applied for conditions away from near-equilibrium. To investigate the kinetic segregation, the crystallization of the mentioned binary mixture is performed at non-equilibrium conditions, i.e., at a certain degree of undercooling. The measured compositions of the grown solid phases are compared to that calculated from the equilibrium and kinetic segregation model. Moreover, the kinetic segregation model is coupled with mass and heat transport limitations. The experimental results are in a good agreement with the solid compositions obtained from the proposed kinetic model, while the solid compositions predicted by equilibrium show too strong segregation. These results demonstrate the effect of interfacial undercooling on the segregation during growth in mixed molecular systems. One part of the thesis concerns the thermal analysis of different polymorphs of the three pure TAGs, being tristearin (SSS), tripalmitin (PPP) and trielaidin (EEE), and their binary mixtures. The reported thermodynamic properties of the pure TAGs are measured by adiabatic and differential scanning calorimetry. From the adiabatic data of melting the beta-polymorphs of SSS, EEE and PPP, the purities are calculated assuming that the compound and impurity form a eutectic mixture. Finally, the phase diagrams of the beta-polymorph of three binary TAG mixtures (EEE-SSS, EEE-PPP, PPP-SSS) were constructed using the DSC data obtained from slow cooling of the melts and subsequent melting of the formed solid phases. All three binary mixtures exhibit limited miscibility of the components in the most of the composition range. For the EEE-SSS system, the SSS-rich mixtures form solid solutions. The components EEE and PPP do not co-crystallize in a solid solution over the whole composition range. Regarding the PPP-SSS mixture, the beta-polymorph yields a typical eutectic phase diagram with some mixing in the regions close to…

Subjects/Keywords: Scheikunde; phase diagram; kinetic segregation; polymorphism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Matovic, M. (2007). Investigation of binary solid phases by calorimetry and kinetic modelling. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/21401

Chicago Manual of Style (16^th Edition):

Matovic, M. “Investigation of binary solid phases by calorimetry and kinetic modelling.” 2007. Doctoral Dissertation, Universiteit Utrecht. Accessed February 27, 2021. http://dspace.library.uu.nl:8080/handle/1874/21401.

MLA Handbook (7^th Edition):

Matovic, M. “Investigation of binary solid phases by calorimetry and kinetic modelling.” 2007. Web. 27 Feb 2021.

Vancouver:

Matovic M. Investigation of binary solid phases by calorimetry and kinetic modelling. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2007. [cited 2021 Feb 27]. Available from: http://dspace.library.uu.nl:8080/handle/1874/21401.

Council of Science Editors:

Matovic M. Investigation of binary solid phases by calorimetry and kinetic modelling. [Doctoral Dissertation]. Universiteit Utrecht; 2007. Available from: http://dspace.library.uu.nl:8080/handle/1874/21401

23. Hanai, Yuki. Relationships between IL-6 gene polymorphism, low BMD and periodontitis in postmenopausal women : IL-6 遺伝子多型が歯周炎と Low BMD に与える影響.

Degree: 博士（歯学）, 2015, Niigata University / 新潟大学

URL: http://hdl.handle.net/10191/32178

►

学位の種類: 博士（歯学）. 報告番号: 甲第4009号. 学位記番号: 新大院博（歯）甲第322号. 学位授与年月日: 平成27年3月23日

Archives of Oral Biology. 2015, 60(4), 533-539.

Objective: IL-6 plays critical roles in bone resorption and the… (more)

Subjects/Keywords: IL-6; Polymorphism; Low BMD; Periodontitis

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APA (6^th Edition):

Hanai, Y. (2015). Relationships between IL-6 gene polymorphism, low BMD and periodontitis in postmenopausal women : IL-6 遺伝子多型が歯周炎と Low BMD に与える影響. (Thesis). Niigata University / 新潟大学. Retrieved from http://hdl.handle.net/10191/32178

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hanai, Yuki. “Relationships between IL-6 gene polymorphism, low BMD and periodontitis in postmenopausal women : IL-6 遺伝子多型が歯周炎と Low BMD に与える影響.” 2015. Thesis, Niigata University / 新潟大学. Accessed February 27, 2021. http://hdl.handle.net/10191/32178.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hanai, Yuki. “Relationships between IL-6 gene polymorphism, low BMD and periodontitis in postmenopausal women : IL-6 遺伝子多型が歯周炎と Low BMD に与える影響.” 2015. Web. 27 Feb 2021.

Vancouver:

Hanai Y. Relationships between IL-6 gene polymorphism, low BMD and periodontitis in postmenopausal women : IL-6 遺伝子多型が歯周炎と Low BMD に与える影響. [Internet] [Thesis]. Niigata University / 新潟大学; 2015. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10191/32178.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hanai Y. Relationships between IL-6 gene polymorphism, low BMD and periodontitis in postmenopausal women : IL-6 遺伝子多型が歯周炎と Low BMD に与える影響. [Thesis]. Niigata University / 新潟大学; 2015. Available from: http://hdl.handle.net/10191/32178

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

24. 池岡, 俊幸. The A>T Polymorphism of the Tribbles Homolog 1 Gene Is Associated with Serum Triglyceride Concentrations in Japanese Community-Dwelling Women : 日本人一般住民女性においてTribbles Homolog 1の遺伝子多型は血清中性脂肪値と関連する.

Degree: 博士(医学), 2015, Nagasaki University / 長崎大学

URL: http://hdl.handle.net/10069/35975

► Recent genome-wide association studies have identified Tribbles homolog 1 (TRIB1) as one of the candidate genes associated with lipid profiles. TRIB1 is known to interact… (more)

Subjects/Keywords: Atherosclerosis; Dyslipidemia; Polymorphism; Tribbles homolog 1; Triglyceride

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APA (6^th Edition):

池岡, �. (2015). The A>T Polymorphism of the Tribbles Homolog 1 Gene Is Associated with Serum Triglyceride Concentrations in Japanese Community-Dwelling Women : 日本人一般住民女性においてTribbles Homolog 1の遺伝子多型は血清中性脂肪値と関連する. (Thesis). Nagasaki University / 長崎大学. Retrieved from http://hdl.handle.net/10069/35975

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

池岡, 俊幸. “The A>T Polymorphism of the Tribbles Homolog 1 Gene Is Associated with Serum Triglyceride Concentrations in Japanese Community-Dwelling Women : 日本人一般住民女性においてTribbles Homolog 1の遺伝子多型は血清中性脂肪値と関連する.” 2015. Thesis, Nagasaki University / 長崎大学. Accessed February 27, 2021. http://hdl.handle.net/10069/35975.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

池岡, 俊幸. “The A>T Polymorphism of the Tribbles Homolog 1 Gene Is Associated with Serum Triglyceride Concentrations in Japanese Community-Dwelling Women : 日本人一般住民女性においてTribbles Homolog 1の遺伝子多型は血清中性脂肪値と関連する.” 2015. Web. 27 Feb 2021.

Vancouver:

池岡 �. The A>T Polymorphism of the Tribbles Homolog 1 Gene Is Associated with Serum Triglyceride Concentrations in Japanese Community-Dwelling Women : 日本人一般住民女性においてTribbles Homolog 1の遺伝子多型は血清中性脂肪値と関連する. [Internet] [Thesis]. Nagasaki University / 長崎大学; 2015. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10069/35975.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

池岡 �. The A>T Polymorphism of the Tribbles Homolog 1 Gene Is Associated with Serum Triglyceride Concentrations in Japanese Community-Dwelling Women : 日本人一般住民女性においてTribbles Homolog 1の遺伝子多型は血清中性脂肪値と関連する. [Thesis]. Nagasaki University / 長崎大学; 2015. Available from: http://hdl.handle.net/10069/35975

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Dalhousie University

25. Holland, Patrick. DRUGS, DIMERS, AND MUTATIONS: INVESTIGATING THE EFFECTS OF LIGANDS AND A ?2-ADRENERGIC POLYMORPHISM ON HOMO/HETERODIMERIZATION OF ?2-ADRENERGIC AND ANGIOTENSIN II TYPE 1 RECEPTORS.

Degree: MS, Department of Pharmacology, 2012, Dalhousie University

URL: http://hdl.handle.net/10222/15245

► GPCRs are known to form dimeric structures, and this affects their pharmacological properties. The ?2AR and AT1aR are GPCRs that are involved the regulation of… (more)

Subjects/Keywords: GPCRs; Signalling; Polymorphism; Dimerization; Receptor Pharmacology

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APA (6^th Edition):

Holland, P. (2012). DRUGS, DIMERS, AND MUTATIONS: INVESTIGATING THE EFFECTS OF LIGANDS AND A ?2-ADRENERGIC POLYMORPHISM ON HOMO/HETERODIMERIZATION OF ?2-ADRENERGIC AND ANGIOTENSIN II TYPE 1 RECEPTORS. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/15245

Chicago Manual of Style (16^th Edition):

Holland, Patrick. “DRUGS, DIMERS, AND MUTATIONS: INVESTIGATING THE EFFECTS OF LIGANDS AND A ?2-ADRENERGIC POLYMORPHISM ON HOMO/HETERODIMERIZATION OF ?2-ADRENERGIC AND ANGIOTENSIN II TYPE 1 RECEPTORS.” 2012. Masters Thesis, Dalhousie University. Accessed February 27, 2021. http://hdl.handle.net/10222/15245.

MLA Handbook (7^th Edition):

Holland, Patrick. “DRUGS, DIMERS, AND MUTATIONS: INVESTIGATING THE EFFECTS OF LIGANDS AND A ?2-ADRENERGIC POLYMORPHISM ON HOMO/HETERODIMERIZATION OF ?2-ADRENERGIC AND ANGIOTENSIN II TYPE 1 RECEPTORS.” 2012. Web. 27 Feb 2021.

Vancouver:

Holland P. DRUGS, DIMERS, AND MUTATIONS: INVESTIGATING THE EFFECTS OF LIGANDS AND A ?2-ADRENERGIC POLYMORPHISM ON HOMO/HETERODIMERIZATION OF ?2-ADRENERGIC AND ANGIOTENSIN II TYPE 1 RECEPTORS. [Internet] [Masters thesis]. Dalhousie University; 2012. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10222/15245.

Council of Science Editors:

Holland P. DRUGS, DIMERS, AND MUTATIONS: INVESTIGATING THE EFFECTS OF LIGANDS AND A ?2-ADRENERGIC POLYMORPHISM ON HOMO/HETERODIMERIZATION OF ?2-ADRENERGIC AND ANGIOTENSIN II TYPE 1 RECEPTORS. [Masters Thesis]. Dalhousie University; 2012. Available from: http://hdl.handle.net/10222/15245

Cornell University

26. Chen, Yi-fan. Phase Behavior Of Cardiolipin.

Degree: PhD, Biophysics, 2012, Cornell University

URL: http://hdl.handle.net/1813/29517

► Cardiolipin is a phospholipid with negatively charged headgroups. This lipid is structurally unique in its quadruple-chained configuration and functionally unique in its nearly exclusive involvement… (more)

▼ Cardiolipin is a phospholipid with negatively charged headgroups. This lipid is structurally unique in its quadruple-chained configuration and functionally unique in its nearly exclusive involvement in the cellular energy production processes. Whether the structural uniqueness leads to the functional exceptionality has long been an open question. Like other phospholipids, cardiolipin is a liquid crystal and demonstrates polymorphism when it is purified and mixed with water. Many studies have been dedicated to examining the phase behavior of cardiolipin liquid crystals in an effort to understand the driving forces behind phase transitions and to ultimately decipher the structure-function relation. However, few, if any, studies have thus far systematically investigated cardiolipin phase behavior in broad temperature and concentration ranges. In this thesis, small- and wide-angle X-ray scattering techniques were employed to study the phase behavior of cardiolipin-water mixtures. A phase diagram was mapped in lipid concentrations from 32.9 wt% to 85.4 wt% and temperatures from -20 °C to 60 °C. Two striking features were observed in this cardiolipin phase diagram: the presence of a lamellar-lamellar phase separation region and a phase displaying crystalline-like X-ray scattering patterns. Based on the X-ray scattering data underlying the phase diagram, electron density maps of the cardiolipin liquid crystals were reconstructed with two different methods and their structural parameters were derived, both within and across a phase boundary. A relationship between phase behavior and structure was observed from this structural information and utilized to construct a "structure map". Based on the structure map, an energetics view was provided to explain the observed phase transitions and to explore the nature and origins of the two striking phase behaviors. Advisors/Committee Members: Gruner, Sol Michael (chair), Pollack, Lois (committee member), Crane, Brian (committee member).

Subjects/Keywords: lyotropic liquid crystal; lipid polymorphism; cardiolipin

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APA (6^th Edition):

Chen, Y. (2012). Phase Behavior Of Cardiolipin. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/29517

Chicago Manual of Style (16^th Edition):

Chen, Yi-fan. “Phase Behavior Of Cardiolipin.” 2012. Doctoral Dissertation, Cornell University. Accessed February 27, 2021. http://hdl.handle.net/1813/29517.

MLA Handbook (7^th Edition):

Chen, Yi-fan. “Phase Behavior Of Cardiolipin.” 2012. Web. 27 Feb 2021.

Vancouver:

Chen Y. Phase Behavior Of Cardiolipin. [Internet] [Doctoral dissertation]. Cornell University; 2012. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/1813/29517.

Council of Science Editors:

Chen Y. Phase Behavior Of Cardiolipin. [Doctoral Dissertation]. Cornell University; 2012. Available from: http://hdl.handle.net/1813/29517

Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

27. Deligiannidis, Aristeidis. Γενετικός πολυμορφισμός των προαγουσών τη φλεγμονή κυτταροκινών και του TGF-β σε ασθενείς με έμφραγμα του μυοκαρδίου.

Degree: 2015, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

URL: http://hdl.handle.net/10442/hedi/37127

►

As it is known, myocardial infarction and the local necrosis it causes to the myocardium, is a source of inflammation. As in every case of… (more)

▼

As it is known, myocardial infarction and the local necrosis it causes to the myocardium, is a source of inflammation. As in every case of inflammation, the immune system activates, producing cytokines, as a response to the inflicted necrosis, promoting scar formation. This mechanism often acts against the best interest of the organism, leaving a dysfunctional remain of tissue.In genetic level, serious research has taken place in order to combine the polymorphisms of these cytokines and the proteins they produce, either concerning the quantity or their quality, with the frequency of appearance and the way diseases evolve.In our research, we located the most popular and most studied polymorphisms of a pliad of cytokines found in the peripheral blood of patients with myocardial infarction. We compared statistically the results with that of a healthy group of people sharing common characteristics (age, sex, risk factors) and ethnical identity (Greek).We took sample from 65 patients with myocardial infarction and 102 healthy people as control group. DNA extraction was done using the PureLink® Genomic DNA Kit. while its decoding was done using the luminex method. The results was later analyzed using the internet statistical package SNPstats, which specializes in single noucleotid polymorphisms. The aforementioned package is free to use at http://bioinfo.iconcologia.net/SNPstats. The level of significance we used was p<0,05.Studying the bibliography until today, the results concerning each cytokine in separate appear to vary and often are conflicting. The geographical factor seems to play an important role, influencing the results. Our study piles up to the total of the scientific knowledge that there is no relation between myocardial infarction and TGFβ +869, +917, IFNγ +874, IL10 -1082, -819, IL6 -174, TNFα -238, -308, IL12β +1188, IL1α -889. IL1β -511, +3962 and IL1R pst11970 polymorphisms, at least as long as Greek population is concerned. In contrary, there was a firm relation between the disease and the existence of C allele at position -592 of IL10 of our female population. Identically, there seems to be a protective role of the CT genotype, of IL1Ra at gene position mspal11100, to its carriers.We suggest that research continues in this direction, taking seriously in concern the geographical factor, expanding in greater numbers of populations, separating myocardial infarction in STEMI and NSTEMI and finally trying if possible to study various combinations of polymorphisms, either concerning the same cytokine or not, as a unified risk factor of myocardial infarction’s appearance.

Είναι γνωστό πως το έμφραγμα του μυοκαρδίου και η τοπική νέκρωση που προκαλεί στο μυοκάρδιο αποτελεί εστία φλεγμονής του οργανισμού. Όπως σε κάθε περίπτωση φλεγμονής, κινητοποιείται ο ανοσοποιητικός μηχανισμός, με βασικό εκπρόσωπο τις παραγόμενες κυτταροκίνες, αντιμαχόμενος τη νεκρωτική περιοχή και προάγοντας την ουλοποίηση. Ο μηχανισμός αυτός, πολλές φορές δεν επενεργεί υπέρ του συμφέροντος του οργανισμού, εγκαταλείποντας δυσλειτουργικό…

Subjects/Keywords: Πολυμορφισμός; Κυτταροκίνες; Έμφραγμα; Polymorphism; Cytokines; Infarction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Deligiannidis, A. (2015). Γενετικός πολυμορφισμός των προαγουσών τη φλεγμονή κυτταροκινών και του TGF-β σε ασθενείς με έμφραγμα του μυοκαρδίου. (Thesis). Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Retrieved from http://hdl.handle.net/10442/hedi/37127

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Deligiannidis, Aristeidis. “Γενετικός πολυμορφισμός των προαγουσών τη φλεγμονή κυτταροκινών και του TGF-β σε ασθενείς με έμφραγμα του μυοκαρδίου.” 2015. Thesis, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Accessed February 27, 2021. http://hdl.handle.net/10442/hedi/37127.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Deligiannidis, Aristeidis. “Γενετικός πολυμορφισμός των προαγουσών τη φλεγμονή κυτταροκινών και του TGF-β σε ασθενείς με έμφραγμα του μυοκαρδίου.” 2015. Web. 27 Feb 2021.

Vancouver:

Deligiannidis A. Γενετικός πολυμορφισμός των προαγουσών τη φλεγμονή κυτταροκινών και του TGF-β σε ασθενείς με έμφραγμα του μυοκαρδίου. [Internet] [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2015. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10442/hedi/37127.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Deligiannidis A. Γενετικός πολυμορφισμός των προαγουσών τη φλεγμονή κυτταροκινών και του TGF-β σε ασθενείς με έμφραγμα του μυοκαρδίου. [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2015. Available from: http://hdl.handle.net/10442/hedi/37127

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Federal da Bahia

28. Paulo Jose Lima Juiz. Association between HLA abd chronic severe periodontitis.

Degree: 2005, Universidade Federal da Bahia

URL: http://www.bibliotecadigital.ufba.br/tde_busca/arquivo.php?codArquivo=2022

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A doença periodontal (DP) é representada por um conjunto de processos inflamatórios e infecciosos que acometem os tecidos periodontais, de etiologia multifatorial, localização sítiodepedente, caracterizada… (more)

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A doença periodontal (DP) é representada por um conjunto de processos inflamatórios e infecciosos que acometem os tecidos periodontais, de etiologia multifatorial, localização sítiodepedente, caracterizada pela interação microrganismo-hospedeiro na superfície do periodonto. Tradicionalmente, a periodontite era analisada estritamente segundo o agente etiológico bacteriano resultado de uma infecção subgengival por um biofilme dental onde os principais microrganismos colonizadores são Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans e Tanerella forsythensis. Somente parte da variabilidade da doença periodontal na população pode ser explicada levando em questão a etiologia bacteriana. É sabido que a susceptibilidade a DP esta relacionada também a uma predisposição genética. No presente estudo foi investigada a associação entre o HLA e a Periodontite crônica severa (PCS) em pacientes mestiços, na faixa etária de 30 a 50 anos, sem distúrbios sistêmicos, residentes em Salvador-BA. Um total de 84 indivíduos foi estudado, sendo 43 pacientes com periodontite crônica severa e 41 indivíduos sem periodontite que constituíram o grupo controle. A avaliação dos parâmetros clínicos se fez por meio do índice de placa visível, índice de sangramento gengival, profundidade de sondagem, recessão gengival, nível de inserção clínica, grau de mobilidade dental e grau de envolvimento de furca. Dentes com coroa totalmente destruída por cárie, com aparelho ortodôntico fixo e parcialmente erupcionados foram excluídos do estudo. A determinação dos alelos dos loci DRB e DQB foi feita pelo método PCR-SSP. Não foi observada diferença estatisticamente significante entre as freqüências dos alelos identificados no grupo de pacientes com PCS e no grupo controle.

Periodontitis is a chronic inflammatory disease of the supporting tissues of the teeth. The gram negative facultative anaerobe Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans and Tanerella forsythensis are implicated as the pathogens in periodontitis. In recent years, convincing evidence has emerged that individual susceptibility to the microbial challenging is determined in part by a genetic predisposition. The aim of the present study was therefore to investigate the incidence of HLA association in 43 patients with severe chronic periodontitis in comparison to 41 probands without periodontits, age of 30-50 years, mestizos, living in Salvador-BA. The clinical assessment included determination of the following parameters: anamnese, visible plaque index, sulcular bleeding index, clinical probing depth, clinical attachment loss and mobility. HLA typing was performed using molecular (PCR-SSP) techniques to DRB and DQB loci. No association with HLA allele frequencies was found in patients relative to controls.

Advisors/Committee Members: Denise Carneiro Lemaire, Paloma Dias da Silva Telles, Eneida de Moraes Marcilio Cerqueira.

Subjects/Keywords: HLA; periodontitis; periodontite; polimorfismo; IMUNOLOGIA; HLA; polymorphism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Juiz, P. J. L. (2005). Association between HLA abd chronic severe periodontitis. (Thesis). Universidade Federal da Bahia. Retrieved from http://www.bibliotecadigital.ufba.br/tde_busca/arquivo.php?codArquivo=2022

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Juiz, Paulo Jose Lima. “Association between HLA abd chronic severe periodontitis.” 2005. Thesis, Universidade Federal da Bahia. Accessed February 27, 2021. http://www.bibliotecadigital.ufba.br/tde_busca/arquivo.php?codArquivo=2022.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Juiz, Paulo Jose Lima. “Association between HLA abd chronic severe periodontitis.” 2005. Web. 27 Feb 2021.

Vancouver:

Juiz PJL. Association between HLA abd chronic severe periodontitis. [Internet] [Thesis]. Universidade Federal da Bahia; 2005. [cited 2021 Feb 27]. Available from: http://www.bibliotecadigital.ufba.br/tde_busca/arquivo.php?codArquivo=2022.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Juiz PJL. Association between HLA abd chronic severe periodontitis. [Thesis]. Universidade Federal da Bahia; 2005. Available from: http://www.bibliotecadigital.ufba.br/tde_busca/arquivo.php?codArquivo=2022

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

29. Hua, Wenjing. Genotypic and phenotypic analyses of two model strains of Cryptococcus neoformans.

Degree: MSc, 2017, McMaster University

URL: http://hdl.handle.net/11375/22202

►

The human pathogenic Cryptococcus neoformans species complex are agents of a common AIDS-defining disease, which causes about 181,000 deaths each year. There are several specific… (more)

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The human pathogenic Cryptococcus neoformans species complex are agents of a common AIDS-defining disease, which causes about 181,000 deaths each year. There are several specific features distinguishing this species from other fungi, including the presence of a polysaccharide capsule and melanin pigment production, both of which contribute to its virulence. A large number of studies about this pathogen used two model strains JEC20 and JEC21. In these studies, these two strains are assumed to be “isogenic”, differ only at the mating type region. Consequently, their phenotypic differences, including virulence, have been attributed to this region. Here, we applied second-generation sequencing and bioinformatics tools to identify sequence polymorphisms between the two genomes. Beside the Mating Type locus, two other regions were found to contain high frequencies of SNPs. To further understand the effects of these loci on the phenotypic differences, four phenotyping assays (mating ability, melanin pigment production, capsule formation, and high temperature growth ability) were conducted on the recombinant progeny obtained from the cross between JEC20 and JEC21. In addition, genomic sequences of these progeny were obtained to identify the complete distributions of other SNPs among the strains. Finally, we identified several novel SNPs contributing to virulence-related traits in this species, which suggest that caution should be placed in attributing phenotypic differences to specific genomic regions in “isogenic” strains derived from classical breeding experiments.

Thesis

Master of Science (MSc)

Cryptococcosis is a globally distributed infection that is prevalent among immune-compromised individuals, such as HIV/AIDS patients. This disease can be attributed to a group of opportunistic fungal pathogens – Cryptococcus neoformans species complex. During the past century, significant resources have been put in an effort to understand its ecology, evolution, life cycle, pathogenesis and virulence factors, and molecular and cellular processes. Most of the laboratory-based studies have relied on two model strains assumed to differ only at the mating type locus. My thesis investigated this assumption and found there are several additional significant genetic differences between these two strains and that such differences contribute to the observed phenotypic differences between them. My results highlight the complexity of genotype-phenotype relationships and the continued evolution of strains even in lab environments in C. neoformans.

Advisors/Committee Members: Xu, Jianping, Biology.

Subjects/Keywords: Cryptococcus neoformans; phenotype; Single nucleotide polymorphism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hua, W. (2017). Genotypic and phenotypic analyses of two model strains of Cryptococcus neoformans. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/22202

Chicago Manual of Style (16^th Edition):

Hua, Wenjing. “Genotypic and phenotypic analyses of two model strains of Cryptococcus neoformans.” 2017. Masters Thesis, McMaster University. Accessed February 27, 2021. http://hdl.handle.net/11375/22202.

MLA Handbook (7^th Edition):

Hua, Wenjing. “Genotypic and phenotypic analyses of two model strains of Cryptococcus neoformans.” 2017. Web. 27 Feb 2021.

Vancouver:

Hua W. Genotypic and phenotypic analyses of two model strains of Cryptococcus neoformans. [Internet] [Masters thesis]. McMaster University; 2017. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/11375/22202.

Council of Science Editors:

Hua W. Genotypic and phenotypic analyses of two model strains of Cryptococcus neoformans. [Masters Thesis]. McMaster University; 2017. Available from: http://hdl.handle.net/11375/22202

Penn State University

30. Garvin, Nathan Michael. ASSOCIATION OF VARIABILITY IN CARDIOVASCULAR RESPONSIVENESS TO REFLEX ACTIVATION OF THE AUTONOMIC NERVOUS SYSTEM WITH GENETICS OF PERIPHERAL SENSORY RECEPTORS.

Degree: 2017, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/14295nmg5181

► Cardiovascular disease accounts for approximately 1 in 3 deaths in the United States and high blood pressure (BP) is one of the risk factors implicated.… (more)

▼ Cardiovascular disease accounts for approximately 1 in 3 deaths in the United States and high blood pressure (BP) is one of the risk factors implicated. Given its importance, extensive research has been done on the regulation of BP and BP responsiveness to stress. “Stress reactivity” has long been used as a metric to assess and predict morbidity and mortality of cardiovascular diseases. For example, exaggerated exercise and noxious cold water-induced BP changes may represent a risk factor for death from cardiovascular causes, act as a predictor for hypertension, and be related to heart disease and cardiovascular events. The source(s) of the variation in cardiovascular reactivity are probably multifaceted and poorly understood. This dissertation explores the thesis that genetic variation accounts for, at least in part, population differences in autonomic responses to stress. The general experimental design was two-fold: 1) the normal range of BP responses to post-exercise circulatory arrest (PECA) following static handgrip (SHG), a common laboratory exercise technique, was rigorously defined; and 2) these norms were used to selectively recruit groups with high and low responses to investigate the mechanisms accounting for the disparate BP responses between groups and to relate these differences to functional single-nucleotide polymorphisms (SNPs) in genes encoding sensory receptors. The first study (Chapter 3) aimed to define the normal range of BP responses to 2-min PECA following 3-min SHG at 30% of maximum voluntary contraction. Testing involved instrumentation for continuous measurement of BP (finger photoplethysmography) and heart rate (ECG) during PECA. Regression modeling of the BP change from control vs. the grip force was used to identify individuals with BP residuals at the highest and lowest response quartile. Average mean arterial pressure change from control was 29±12 mmHg during PECA after 3 min of SHG. Grip force during SHG accounted for ~37% of the variability in BP response. High and low response groups were defined as having a BP residual of +6 and –6 mmHg, respectively. The second study (Chapters 4-9) was designed to compare these explicitly defined cohorts with stressors that evoke autonomic responses and to test for associations of responsiveness to SNPs in the genes coding for several sensory afferent receptors. Thus, the aim of the study was to associate a BP phenotype with sensory afferent genotype. Volunteers recruited from each group performed up to 6 protocols in a single ~4 hour visit to the lab. Subjects were instrumented for the continuous measurement of BP (finger photoplethysmography), heart rate (ECG), blood flow (duplex Doppler ultrasound), and muscle sympathetic nerve activity (peroneal microneurography) and performed exercise (SHG and rhythmic handgrip (RHG); both followed by PECA), caloric stimulations of the hand (cold, hot, and thermoneutral water immersion), and hypercapnic, hyperoxic rebreathing. In general, there was an inter-stressor response specificity to… Advisors/Committee Members: James Anthony Pawelczyk, Dissertation Advisor/Co-Advisor, James Anthony Pawelczyk, Committee Chair/Co-Chair, David Nathan Proctor, Committee Member, Gail Doreen Thomas, Committee Member, John E Hayes, Outside Member.

Subjects/Keywords: blood pressure; autonomic; single nucleotide polymorphism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Garvin, N. M. (2017). ASSOCIATION OF VARIABILITY IN CARDIOVASCULAR RESPONSIVENESS TO REFLEX ACTIVATION OF THE AUTONOMIC NERVOUS SYSTEM WITH GENETICS OF PERIPHERAL SENSORY RECEPTORS. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/14295nmg5181

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Garvin, Nathan Michael. “ASSOCIATION OF VARIABILITY IN CARDIOVASCULAR RESPONSIVENESS TO REFLEX ACTIVATION OF THE AUTONOMIC NERVOUS SYSTEM WITH GENETICS OF PERIPHERAL SENSORY RECEPTORS.” 2017. Thesis, Penn State University. Accessed February 27, 2021. https://submit-etda.libraries.psu.edu/catalog/14295nmg5181.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Garvin, Nathan Michael. “ASSOCIATION OF VARIABILITY IN CARDIOVASCULAR RESPONSIVENESS TO REFLEX ACTIVATION OF THE AUTONOMIC NERVOUS SYSTEM WITH GENETICS OF PERIPHERAL SENSORY RECEPTORS.” 2017. Web. 27 Feb 2021.

Vancouver:

Garvin NM. ASSOCIATION OF VARIABILITY IN CARDIOVASCULAR RESPONSIVENESS TO REFLEX ACTIVATION OF THE AUTONOMIC NERVOUS SYSTEM WITH GENETICS OF PERIPHERAL SENSORY RECEPTORS. [Internet] [Thesis]. Penn State University; 2017. [cited 2021 Feb 27]. Available from: https://submit-etda.libraries.psu.edu/catalog/14295nmg5181.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Garvin NM. ASSOCIATION OF VARIABILITY IN CARDIOVASCULAR RESPONSIVENESS TO REFLEX ACTIVATION OF THE AUTONOMIC NERVOUS SYSTEM WITH GENETICS OF PERIPHERAL SENSORY RECEPTORS. [Thesis]. Penn State University; 2017. Available from: https://submit-etda.libraries.psu.edu/catalog/14295nmg5181

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations