You searched for subject:(Polydopamine).
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University of Waterloo
1.
Yang, Fut.
Self-polymerized Dopamine Thin Film as Bioadhesive.
Degree: 2012, University of Waterloo
URL: http://hdl.handle.net/10012/6531 
► Dopamine is an interesting biomolecule that functions as a neurotransmitter in the brain. It has been found able to stick to almost all surfaces due…
(more)
▼ Dopamine is an interesting biomolecule that functions as a neurotransmitter in the brain. It has been found able to stick to almost all surfaces due to its unique catecholamine structure. Under alkaline conditions, the catechol functional group oxidizes to quinone allowing dopamine to self-polymerize and form thin films on support surfaces. The facts that dopamine can be coated to virtually any materials and the amine and catechol functional groups support a variety of reactions with organic species make polydopamine an attractive multifunctional bioadhesive/coating. To date, most of research on polydopamine has been focusing on its applications as thin films and little attention has been paid to the adhesion aspect of the material.
In the study, we evaluated the properties of self-polymerized dopamine thin films as a bioadhesive. The thesis consists of three consecutive studies: (i) characterization of the adhesion properties of polydopamine thin films; (ii) investigation of the mechanical properties of polydopamine thin films; and (iii) exploration of the potential of polydopamine thin films as a wet adhesive. Fundamental insights on the wettability, adhesion behaviours, and mechanical properties of polydopamine thin films for both wet and dry conditions were derived through sets of well-designed contact angle, contact adhesion, and contact deformation experiments. It was found that dopamine is able to coat plastic, ceramic and metal surfaces, and join or bond rigid substrates but might not be suitable for joining soft or flexible parts as polydopamine is fairly rigid and the bonding might be too slow and too rigid for practical applications if polydopamine is directly used as an adhesive. Based on the understanding, a new strategy for fabricating underwater adhesive was proposed and tested. In the strategy, polydopamine with ferric ion as the oxidant was utilized as a cross-linker to alginate solution, effectively turning the solution into a wet adhesive, which demonstrated better practical performances than other studies; the adhesive was able to produce a permanent tensile adhesive strength of 80 kPa joining aluminum and glass with macroscopic roughness at the interface within 2 hours of curing time.
Inspired by the results from the contact deformation experiments, we were able to extend the JKR theory with the well-known plate theory to accommodate the deformation of nanometer thin films, obtaining their elasticity. We termed this extended theory the “thin film contact mechanics” and validated the theory against gold thin films and found it predicted the mechanical behaviours of the thin films fairly well.
Subjects/Keywords: wet adhesive; polydopamine
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APA (6th Edition):
Yang, F. (2012). Self-polymerized Dopamine Thin Film as Bioadhesive. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/6531
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Yang, Fut. “Self-polymerized Dopamine Thin Film as Bioadhesive.” 2012. Thesis, University of Waterloo. Accessed October 14, 2019.
http://hdl.handle.net/10012/6531.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Yang, Fut. “Self-polymerized Dopamine Thin Film as Bioadhesive.” 2012. Web. 14 Oct 2019.
Vancouver:
Yang F. Self-polymerized Dopamine Thin Film as Bioadhesive. [Internet] [Thesis]. University of Waterloo; 2012. [cited 2019 Oct 14].
Available from: http://hdl.handle.net/10012/6531.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Yang F. Self-polymerized Dopamine Thin Film as Bioadhesive. [Thesis]. University of Waterloo; 2012. Available from: http://hdl.handle.net/10012/6531
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
NSYSU
2.
Peng, Shi-wei.
Investigation of Bio-Inspired Polydopamine Using Atomic Force Microscopy.
Degree: Master, Chemistry, 2015, NSYSU
URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0621115-154800
► Dopamine solution will conduct autoxidation and self-polymerization to form polydopamine particles in alkaline tris-(hydroxymethyl)aminomethane (Tris) buffer solution. At the same time, the ploydopamine deposition onto…
(more)
▼ Dopamine solution will conduct autoxidation and self-polymerization to form
polydopamine particles in alkaline tris-(hydroxymethyl)aminomethane (Tris) buffer solution. At the same time, the ploydopamine deposition onto various substrates via
covalent bond or non-covalent bond such as hydrogen bond, electrostatic interaction, Ï-Ï interaction, van der waal interaction. In this study, we used atomically flat mica to investigate the growth mode and the growth mechanism of
polydopamine by atomic force microscopy (AFM), x-ray photoelectron spectroscopy (XPS), and contact angle measurment. On the other hand, we also used
polydopamine-modified AFM tip to
detect the interaction with various substrates and designed surface patterning on polydimethylsiloxane (PDMS). The results show that the monolayer of
polydopamine film is completed within 300 sec and the roughness had significantly changed compared with bare mica. The
polydopamine-modified AFM tip had the strongest interaction with
Highly Oriented Pyrolytic Graphite (HOPG) due to the strong Ï-Ï interaction between the aromatic rings structure on
polydopamine and the planar structure of sp2 orbital on HOPG. Finally, the surface patterning on PDMS by
polydopamine successfully modified Au nanoparticles and Ag nanoparticles on specific area.
Advisors/Committee Members: Shang-Wu Ding (chair), Shuchen Hsieh (committee member), Huey-Shan Hung (chair).
Subjects/Keywords: patterning; AFM; polydopamine; polydimethylsiloxane; adhesion
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APA (6th Edition):
Peng, S. (2015). Investigation of Bio-Inspired Polydopamine Using Atomic Force Microscopy. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0621115-154800
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Peng, Shi-wei. “Investigation of Bio-Inspired Polydopamine Using Atomic Force Microscopy.” 2015. Thesis, NSYSU. Accessed October 14, 2019.
http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0621115-154800.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Peng, Shi-wei. “Investigation of Bio-Inspired Polydopamine Using Atomic Force Microscopy.” 2015. Web. 14 Oct 2019.
Vancouver:
Peng S. Investigation of Bio-Inspired Polydopamine Using Atomic Force Microscopy. [Internet] [Thesis]. NSYSU; 2015. [cited 2019 Oct 14].
Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0621115-154800.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Peng S. Investigation of Bio-Inspired Polydopamine Using Atomic Force Microscopy. [Thesis]. NSYSU; 2015. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0621115-154800
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Carnegie Mellon University
3.
Klosterman, Luke J.
Deposition, Oxidation, and Adhesion Mechanisms of Conformal Polydopamine Films.
Degree: 2016, Carnegie Mellon University
URL: http://repository.cmu.edu/dissertations/702
► The oxidation of dopamine in aqueous solutions deposits thin conformal films on a wide variety of material surfaces. These films consist of a material known…
(more)
▼ The oxidation of dopamine in aqueous solutions deposits thin conformal films on a wide variety of material surfaces. These films consist of a material known as polydopamine (PDA), and they exhibit chemical and structural similarities to melanin pigments and adhesive proteins secreted by mussels. The facile synthesis and versatile adhesion of PDA enable the functional modification of numerous material surfaces for applications in biomedical devices, energy storage, and water purification. This thesis details fundamental investigations into the deposition, oxidation, and adhesive mechanisms of PDA films. Depositing PDA films on substrates with different controlled chemistries revealed the importance of solution pH and initial deposition rates on the morphology of the films. The deposition of PDA molecules with increasing pH depends on two competing factors: increased generation rate of PDA molecules versus increased solubility due to catechol ionization. The areal density and coverage of three-dimensional PDA islands is influenced by the surface charge and hydrophobicity of the substrate in aqueous solutions. Spectroscopic and electrochemical characterization of PDA films revealed that redox-inactive metal cations can accelerate the oxidation of PDA. The generation of radicals of 5,6-dihydroxyindole were monitored in situ via ultraviolet-visible spectroscopy as a function of cation concentration and pH. The extent of oxidation was quantified by cyclic voltammetry. The resulting oxidation modifies the metal sorption properties of PDA by generating more carboxylic acid groups and enhancing the iron chelation of the films. The adhesive stability of PDA films was characterized by delamination kinetics of films on SiO2 and indium tin oxide (ITO). PDA film adhesion is a substrate, salt, and oxidation-dependent phenomenon. Long-term adhesive stability of PDA films can be promoted by use of higher dopamine concentrations during synthesis, incorporation of multivalent cations, and avoiding alkaline conditions and strongly oxidizing electrical bias. Elastic moduli of PDA films were quantified by compressive thin film wrinkling, and the measured value of 2.0 ± 0.9 GPA agrees with simulations of PDA based on an oligomeric aggregate model. This thesis helps develop a framework for understanding the synthesis, composition, microstructure, and stability of PDA films.
Subjects/Keywords: melanin; polydopamine; thin film
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APA (6th Edition):
Klosterman, L. J. (2016). Deposition, Oxidation, and Adhesion Mechanisms of Conformal Polydopamine Films. (Thesis). Carnegie Mellon University. Retrieved from http://repository.cmu.edu/dissertations/702
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Klosterman, Luke J. “Deposition, Oxidation, and Adhesion Mechanisms of Conformal Polydopamine Films.” 2016. Thesis, Carnegie Mellon University. Accessed October 14, 2019.
http://repository.cmu.edu/dissertations/702.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Klosterman, Luke J. “Deposition, Oxidation, and Adhesion Mechanisms of Conformal Polydopamine Films.” 2016. Web. 14 Oct 2019.
Vancouver:
Klosterman LJ. Deposition, Oxidation, and Adhesion Mechanisms of Conformal Polydopamine Films. [Internet] [Thesis]. Carnegie Mellon University; 2016. [cited 2019 Oct 14].
Available from: http://repository.cmu.edu/dissertations/702.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Klosterman LJ. Deposition, Oxidation, and Adhesion Mechanisms of Conformal Polydopamine Films. [Thesis]. Carnegie Mellon University; 2016. Available from: http://repository.cmu.edu/dissertations/702
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Ottawa
4.
Steeves, Alexander.
Physicochemical and Cellular Analysis of Polydopamine for Use as an Orthopaedic Bioadhesive
.
Degree: 2018, University of Ottawa
URL: http://hdl.handle.net/10393/38032
► Polydopamine (PDA), a unique bioinspired polymer, has been a subject of interest in fields including orthopedic biomaterials and antibacterial surfaces. Its osteogenic effects and ability…
(more)
▼ Polydopamine (PDA), a unique bioinspired polymer, has been a subject of interest in fields including orthopedic biomaterials and antibacterial surfaces. Its osteogenic effects and ability to control surface traits through precise variables (e.g., pH, temperature) have led to its use as a coating in the enhancement of a wide range of materials, including metals and ceramics. In this Thesis, two studies were carried out to better understand the capability and mechanism of PDA-mediated bioactivity. In the first study, we investigated whether PDA coatings can further enhance the bioactivity of nanoporous Titanium (NPTi). While physicochemical traits were in line with literature, PDA was effective in enhancing cell proliferation, beyond NPTi, as early as 8 hours with enhancement in cell spreading and focal adhesion prevalence as early as 1 hour. No changes in adsorptive capacity were found, suggesting a serum-independent component (SIC) of the surface. The second study was focused on (1) determining how treatment parameters influence the physiochemical makeup of PDA surfaces, (2) assessing how PDA surfaces influence stem cell behavior and (3) confirming and investigating the SIC of PDA effect. Results confirm that there is indeed a SIC of PDA coatings with enhancement in cell spreading that improves with the increased size and density of PDA particles. Our findings show that the SIC works in concert with circulating sera to elicit the bioactive effects of PDA. The novel rPDA surface, obtained by adding rotation during the coating deposition, is also shown to elevate bioactivity during normal culturing, beyond classical coatings, with ongoing work suggesting enhancement in the osteogenic differentiation of hMSCs. Taken together, this work has demonstrated novel aspects underlying the potential and mechanism of action for the bioactivity of PDA, ultimately providing new evidence supporting the use of PDA as a biomedical material.
Subjects/Keywords: biomaterial;
polydopamine;
stem cell;
titanium
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APA (6th Edition):
Steeves, A. (2018). Physicochemical and Cellular Analysis of Polydopamine for Use as an Orthopaedic Bioadhesive
. (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/38032
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Steeves, Alexander. “Physicochemical and Cellular Analysis of Polydopamine for Use as an Orthopaedic Bioadhesive
.” 2018. Thesis, University of Ottawa. Accessed October 14, 2019.
http://hdl.handle.net/10393/38032.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Steeves, Alexander. “Physicochemical and Cellular Analysis of Polydopamine for Use as an Orthopaedic Bioadhesive
.” 2018. Web. 14 Oct 2019.
Vancouver:
Steeves A. Physicochemical and Cellular Analysis of Polydopamine for Use as an Orthopaedic Bioadhesive
. [Internet] [Thesis]. University of Ottawa; 2018. [cited 2019 Oct 14].
Available from: http://hdl.handle.net/10393/38032.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Steeves A. Physicochemical and Cellular Analysis of Polydopamine for Use as an Orthopaedic Bioadhesive
. [Thesis]. University of Ottawa; 2018. Available from: http://hdl.handle.net/10393/38032
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
NSYSU
5.
He, Gong-chun.
In situ monitoring of the photocatalytic degradation of Methyleneblue on a Ag/PDA/[email protected] SERS substrate.
Degree: Master, Chemistry, 2016, NSYSU
URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0708116-172523
► Glass microfibers decorated with silver/
polydopamine/copper-oxide films(Ag/PDA/
[email protected]) were fabricated by a simple preparation method and their effectiveness as surface-enhanced Raman scattering (SERS) substrates evaluated using the…
(more)
▼ Glass microfibers decorated with silver/
polydopamine/copper-oxide films(Ag/PDA/
[email protected]) were fabricated by a simple preparation method and their effectiveness as surface-enhanced Raman scattering (SERS) substrates evaluated using the probe molecule Methylene Blue. Electron transfer from silver nanoparticles to CuO through the PDA film is proposed as a possible mechanism to account for the strong enhancement of SERS intensity. An enhancement value of 6.84 Ã 108 was observed, which is suitable for single molecule detection. Furthermore Ag/PDA/
[email protected] was found to degrade methylene blue in the presence of sunlight and the band gap was 2.7 eV. This confirms that Ag/PDA/
[email protected] can be excited by visible light. We used Raman spectroscopy to analyze the photocatalytic degradation reaction and further analyze the reaction intermediates and bond breaking mechanism. Our results demonstrate that Ag/PDA/
[email protected] exhibits a strong SERS enhancement during photocatalytic degradation of Methylene Blue and is a promising candidate as a more general SERS substrate.
Advisors/Committee Members: Shu-chen Hsieh (committee member), Shu-Ling Hsieh (chair), Shangwu (Sam) Ding (chair).
Subjects/Keywords: photocatalytic degradation; SERS; Glass Microfiber; Polydopamine
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APA (6th Edition):
He, G. (2016). In situ monitoring of the photocatalytic degradation of Methyleneblue on a Ag/PDA/[email protected] SERS substrate. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0708116-172523
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
He, Gong-chun. “In situ monitoring of the photocatalytic degradation of Methyleneblue on a Ag/PDA/[email protected] SERS substrate.” 2016. Thesis, NSYSU. Accessed October 14, 2019.
http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0708116-172523.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
He, Gong-chun. “In situ monitoring of the photocatalytic degradation of Methyleneblue on a Ag/PDA/[email protected] SERS substrate.” 2016. Web. 14 Oct 2019.
Vancouver:
He G. In situ monitoring of the photocatalytic degradation of Methyleneblue on a Ag/PDA/[email protected] SERS substrate. [Internet] [Thesis]. NSYSU; 2016. [cited 2019 Oct 14].
Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0708116-172523.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
He G. In situ monitoring of the photocatalytic degradation of Methyleneblue on a Ag/PDA/[email protected] SERS substrate. [Thesis]. NSYSU; 2016. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0708116-172523
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Texas – Austin
6.
Miller, Daniel Joseph Lang.
Assessment of fouling in native and surface-modified water purification membranes.
Degree: PhD, Chemical Engineering, 2013, University of Texas – Austin
URL: http://hdl.handle.net/2152/25182
► Fouling is a major obstacle to the implementation of membranes in water purification applications. Hydrophilization of the membrane surface tends to mitigate fouling because hydrophobic…
(more)
▼ Fouling is a major obstacle to the implementation of membranes in water purification applications. Hydrophilization of the membrane surface tends to mitigate fouling because hydrophobic interactions between foulants and the membrane are reduced.
Polydopamine was deposited onto membranes to render their surfaces hydrophilic. The chemical structure of
polydopamine, which was previously ambiguous, was investigated by many spectroscopic techniques. While previously thought to consist of covalently-linked monomers,
polydopamine was found to be an aggregate of partly-oxidized dopamine units linked by strong, non-covalent secondary interactions.
Polydopamine was also used as a platform for the molecular conjugation of other anti-fouling materials, such as poly(ethylene glycol), to the membrane surface. Membrane fouling was assessed by constant permeate flux crossflow filtration with an oil/water emulsion feed. The threshold flux – the flux at which the rate of fouling significantly increases – was determined by a well-established flux stepping technique. Membrane resistance evolution during fouling was compared for constant flux and constant transmembrane pressure operation using unmodified membranes. Below the threshold flux (slow fouling), good agreement in resistance evolution was found between the two operational modes; above the threshold flux, significant deviation was observed. The effect of
polydopamine and
polydopamine-g-poly(ethylene glycol) surface modifications was studied under constant flux crossflow fouling conditions. The surface modifications were found to increase the membrane resistance, resulting in higher transmembrane pressures in the modified membranes than in the unmodified membranes at fluxes below the threshold flux. Modified membranes were also compared to unmodified membranes with the same pure water permeance (same initial resistance). In this case, the modified membranes had lower transmembrane pressures during fouling than the unmodified membranes, suggesting that a preferred method of membrane surface modification is to begin with a membrane of higher permeance than required, and then surface-modify it to achieve the desired permeance. The efficacy of
polydopamine and
polydopamine-g-poly(ethylene glycol) surface modifications in reducing biofouling was also evaluated. Modified membranes showed reduced protein and bacterial adhesion in short-term tests, which are commonly used to assess biofouling propensity. However, long-term operation under hydrodynamic conditions mimicking those of an industrial module showed no benefit of the hydrophilic coatings in limiting biofouling.
Advisors/Committee Members: Freeman, B. D. (Benny D.) (advisor), Paul, Donald R. (advisor).
Subjects/Keywords: Membrane; Fouling; Polydopamine; Water purification; Ultrafiltration
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APA ·
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APA (6th Edition):
Miller, D. J. L. (2013). Assessment of fouling in native and surface-modified water purification membranes. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/25182
Chicago Manual of Style (16th Edition):
Miller, Daniel Joseph Lang. “Assessment of fouling in native and surface-modified water purification membranes.” 2013. Doctoral Dissertation, University of Texas – Austin. Accessed October 14, 2019.
http://hdl.handle.net/2152/25182.
MLA Handbook (7th Edition):
Miller, Daniel Joseph Lang. “Assessment of fouling in native and surface-modified water purification membranes.” 2013. Web. 14 Oct 2019.
Vancouver:
Miller DJL. Assessment of fouling in native and surface-modified water purification membranes. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2013. [cited 2019 Oct 14].
Available from: http://hdl.handle.net/2152/25182.
Council of Science Editors:
Miller DJL. Assessment of fouling in native and surface-modified water purification membranes. [Doctoral Dissertation]. University of Texas – Austin; 2013. Available from: http://hdl.handle.net/2152/25182
7.
Ponzio, Florian.
Synthesis at different interfaces of bio-inspired films from mussels' byssus : influence of the oxidant nature at the solid/liquid interface and the addition of polymer at the air/water interface : Synthèse à différentes interfaces de films bio-inspirés du byssus de la moule : Influence de la nature de l'oxydant à l'interface solide-liquide et d'ajout de polymères à l'interface air-eau.
Degree: Docteur es, Chimie physique, 2016, Université de Strasbourg
URL: http://www.theses.fr/2016STRAE041
► Les matériaux à base de polydopamine (PDA) s’inspirent de la forte adhésion du byssus de la moule sous l’eau. L’oligomérisation de la dopamine dans un…
(more)
▼ Les matériaux à base de polydopamine (PDA) s’inspirent de la forte adhésion du byssus de la moule sous l’eau. L’oligomérisation de la dopamine dans un milieu basique permet la formation de revêtement de PDA sur n’importe quel matériau. En plus de la simplicité du procédé celui-ci est vert et versatile. La PDA a des propriétés similaires aux mélanines, d’où son utilisation dans le domaine des phénomènes de conversion d’énergie, de l’environnement et du biomédical. Cependant la structure de la PDA étant inconnue, l’élaboration de matériaux basés sur la relation structure propriétés est difficile. L’un des buts de cette thèse a été de comprendre cette relation pour élaborer de nouveaux matériaux de PDA. En choisissant l’oxydant adéquat nous avons déposé un film épais, superhydrophile et biocompatible sur n’importe quels substrats. De plus nous avons découverts la possibilité de former des films de PDA à l’interface air/eau. L’étude de ce phénomène a permis de former des membranes autosupportées et stimuli responsives.
Polydopamine (PDA) materials are inspired from mussels’ byssus strong adhesion underwater. The oligomerization of dopamine in a basic medium allows forming a PDA coating on virtually any materials. In addition to the simplicity, ecofriendly and versatility of the deposition method, PDA has properties similar to those of melanin pigments and displays many outstanding properties. Thus PDAis widely used in energy, environmental and biomedical sciences. However design of PDA based new materials with tailored properties is a challenge since its structure is still unknown. In that sense one of the aims of this thesis is to gain knowledge in PDA structure-property relationship in order to design PDA materials with new properties. By choosing the appropriate oxidant we deposited thick and superhydrophylic films on any materials for the elaboration of low fouling and biocompatible surfaces. Additionally we discovered the possibility to form PDA films at the air/water interface. The investigation of this phenomenon led to the formation of stimuli responsive free standing membranes.
Advisors/Committee Members: Ball, Vincent (thesis director).
Subjects/Keywords: Polydopamine; Films minces; Mécanisme réactionel; Superhydrophilie; Biomimétisme; Matériaux stimuli responsifs; Polydopamine; Thin films; Reaction mechanism; Superhydrophilicity; Biomimetism; Stimuli responsive materials; 541.3
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APA (6th Edition):
Ponzio, F. (2016). Synthesis at different interfaces of bio-inspired films from mussels' byssus : influence of the oxidant nature at the solid/liquid interface and the addition of polymer at the air/water interface : Synthèse à différentes interfaces de films bio-inspirés du byssus de la moule : Influence de la nature de l'oxydant à l'interface solide-liquide et d'ajout de polymères à l'interface air-eau. (Doctoral Dissertation). Université de Strasbourg. Retrieved from http://www.theses.fr/2016STRAE041
Chicago Manual of Style (16th Edition):
Ponzio, Florian. “Synthesis at different interfaces of bio-inspired films from mussels' byssus : influence of the oxidant nature at the solid/liquid interface and the addition of polymer at the air/water interface : Synthèse à différentes interfaces de films bio-inspirés du byssus de la moule : Influence de la nature de l'oxydant à l'interface solide-liquide et d'ajout de polymères à l'interface air-eau.” 2016. Doctoral Dissertation, Université de Strasbourg. Accessed October 14, 2019.
http://www.theses.fr/2016STRAE041.
MLA Handbook (7th Edition):
Ponzio, Florian. “Synthesis at different interfaces of bio-inspired films from mussels' byssus : influence of the oxidant nature at the solid/liquid interface and the addition of polymer at the air/water interface : Synthèse à différentes interfaces de films bio-inspirés du byssus de la moule : Influence de la nature de l'oxydant à l'interface solide-liquide et d'ajout de polymères à l'interface air-eau.” 2016. Web. 14 Oct 2019.
Vancouver:
Ponzio F. Synthesis at different interfaces of bio-inspired films from mussels' byssus : influence of the oxidant nature at the solid/liquid interface and the addition of polymer at the air/water interface : Synthèse à différentes interfaces de films bio-inspirés du byssus de la moule : Influence de la nature de l'oxydant à l'interface solide-liquide et d'ajout de polymères à l'interface air-eau. [Internet] [Doctoral dissertation]. Université de Strasbourg; 2016. [cited 2019 Oct 14].
Available from: http://www.theses.fr/2016STRAE041.
Council of Science Editors:
Ponzio F. Synthesis at different interfaces of bio-inspired films from mussels' byssus : influence of the oxidant nature at the solid/liquid interface and the addition of polymer at the air/water interface : Synthèse à différentes interfaces de films bio-inspirés du byssus de la moule : Influence de la nature de l'oxydant à l'interface solide-liquide et d'ajout de polymères à l'interface air-eau. [Doctoral Dissertation]. Université de Strasbourg; 2016. Available from: http://www.theses.fr/2016STRAE041
8.
Lefebvre, Louis.
Développement et caractérisation de mousses cellulaires élastomères pour l’intensification des procédés : Development and characterization of Open Cell Polyurethane Foam for process intensification.
Degree: Docteur es, Génie des procédés, 2019, Lyon
URL: http://www.theses.fr/2019LYSE1028
► Les mousses solides, en polyuréthane, sont connues pour avoir des propriétés de transports intéressantes telles que des faibles pertes de charges engendrées ou une grande…
(more)
▼ Les mousses solides, en polyuréthane, sont connues pour avoir des propriétés de transports intéressantes telles que des faibles pertes de charges engendrées ou une grande surface spécifique développée permettant une bonne évacuation de la chaleur. Cependant, elles ne sont pas utilisées en tant que support catalytique à cause des méthodes de déposition actuelles qui provoquent une altération de leurs propriétés mécaniques. Nous avons tout d’abord utilisé une nouvelle méthode de déposition basée sur la polydopamine(PDA), un polymère aux propriétés intéressantes, d’adhésion et de réduction. La PDA va venir recouvrir de manière homogène notre support puis va servir d’intermédiaire pour le dépôt de différentes phases active, qu’elles soient commerciales ou synthétisées in-situ. Par la suite, nos supports ont été employés dans plusieurs réactions, qu’elles soient monophasiques (liquide) ou bi-phasiques (gaz/liquide), afin de mettre en avant l’efficacité et la stabilité du dépôt de nos phases actives. De plus, il nous a été possible de déposer une phase active intéressante pour la production d’hydrogène. L’étude cinétique de cette réaction à basse température a été réalisée et a montré des résultats prometteurs pour le domaine des énergies renouvelables. Enfin, la dernière partie est consacrée à la mise en place de notre support structuré au sein d’un réacteur innovant, permettant d’utiliser les propriétés mécaniques du dit support afin d’améliorer les propriétés de transfert de matière
Solid foams, made with polyurethane, are well known for their interesting transport properties such as low pressure drop or high specific surface area. However, there are not used as catalytic support due to actual deposition method which causes an alteration of their mechanical properties. First, we used a new deposition method using polydopamine (PDA), a polymer with interesting adhesive and reducing properties. The PDA layer will cover homogenously our support then will act as intermediary for active phase deposition, whether they are commercially available or synthetized in-situ. Afterward, our supports were tested for several catalytic reactions, whether monophasic (liquid phase) or biphasic (gas/liquid) to show the active phase efficiency and stability. Furthermore, we successfully deposited a good active phase (cobalt) for hydrogen production. Kinetic study at low temperature were done and shown promising results for sustainable energy production. Finally, the last part was devoted to the use of our soft structured catalytic support within a new reactor, allowing to use its mechanical properties to improve mass transfer
Advisors/Committee Members: Edouard, David (thesis director), Tayakout, Mélaz (thesis director).
Subjects/Keywords: Mousse de polyuréthane; Polydopamine; Fonctionnalisation; Support catalytique structuré souple; Polyurethane foam; Polydopamine; Functionalization; Soft Structured Catalytic Support (S2CS); 660
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APA (6th Edition):
Lefebvre, L. (2019). Développement et caractérisation de mousses cellulaires élastomères pour l’intensification des procédés : Development and characterization of Open Cell Polyurethane Foam for process intensification. (Doctoral Dissertation). Lyon. Retrieved from http://www.theses.fr/2019LYSE1028
Chicago Manual of Style (16th Edition):
Lefebvre, Louis. “Développement et caractérisation de mousses cellulaires élastomères pour l’intensification des procédés : Development and characterization of Open Cell Polyurethane Foam for process intensification.” 2019. Doctoral Dissertation, Lyon. Accessed October 14, 2019.
http://www.theses.fr/2019LYSE1028.
MLA Handbook (7th Edition):
Lefebvre, Louis. “Développement et caractérisation de mousses cellulaires élastomères pour l’intensification des procédés : Development and characterization of Open Cell Polyurethane Foam for process intensification.” 2019. Web. 14 Oct 2019.
Vancouver:
Lefebvre L. Développement et caractérisation de mousses cellulaires élastomères pour l’intensification des procédés : Development and characterization of Open Cell Polyurethane Foam for process intensification. [Internet] [Doctoral dissertation]. Lyon; 2019. [cited 2019 Oct 14].
Available from: http://www.theses.fr/2019LYSE1028.
Council of Science Editors:
Lefebvre L. Développement et caractérisation de mousses cellulaires élastomères pour l’intensification des procédés : Development and characterization of Open Cell Polyurethane Foam for process intensification. [Doctoral Dissertation]. Lyon; 2019. Available from: http://www.theses.fr/2019LYSE1028
NSYSU
9.
Chen, Jyun-de.
Fabrication of metal-semiconductor materials by polydopamine and its application in SERS.
Degree: Master, Chemistry, 2016, NSYSU
URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0704116-111522
► Surface-Enhanced Raman Spectroscopy ( SERS ) has broad applications in the fields of biology, medicine and chemistry due to high sensitivity, high resolution and high…
(more)
▼ Surface-Enhanced Raman Spectroscopy ( SERS ) has broad applications in the fields of biology, medicine and chemistry due to high sensitivity, high resolution and high selectivity to the adsorbate. In recent years, it was reported that materials combining metal and semiconductor can greatly increase the SERS enhancement effect. In this experiment, we synthesized Ag/PDA/
[email protected] which combined metal and semiconductor using
polydopamine, and had the benefits of being environmentally friendly, exhibiting good adsorption, and being a strong reductant. We applied the material to SERS and found that the SERS enhancement effect increased significantly, making it an attractive SERS substrate. We observed that the material exhibited the rod-stacking structure by SEM. We performed qualitative and quantitative analysis of the material by XRD, EDS and ICP-MS. From the results of XPS, we observed the charge transfer effect between the silver nanoparticles and zinc oxide, which explains the increased SERS enhancement effect. By tuning the deposition time of the silver nanoparticles, we tested the detection limit of Rhodamine B and monitored the photocatalytic degradation. We found that the best condition of deposition time was 8hr, and the photocatalytic degradation was first-order reaction. Because the material possessed both high sensitivity of SERS and catalytic activity of reaction, we repeated the experiment in five times on the substrate of best condition. We found that the substrate could maintain considerable catalytic activity, appropriate for serving as recyclable sensing material. It would have good prospect to apply to the trace sensing of organic pollutants and fabricating the SERS substrate which could be the catalyst.
Advisors/Committee Members: Shu-chen Hsieh (committee member), Shu-chen Hsieh (chair), Shang-Wu Ding (chair), Shu-Ling Hsieh (chair).
Subjects/Keywords: zinc oxide; reductant; polydopamine; silver nanoparticles; Surface-Enhanced Raman Spectroscopy
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APA (6th Edition):
Chen, J. (2016). Fabrication of metal-semiconductor materials by polydopamine and its application in SERS. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0704116-111522
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Chen, Jyun-de. “Fabrication of metal-semiconductor materials by polydopamine and its application in SERS.” 2016. Thesis, NSYSU. Accessed October 14, 2019.
http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0704116-111522.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Chen, Jyun-de. “Fabrication of metal-semiconductor materials by polydopamine and its application in SERS.” 2016. Web. 14 Oct 2019.
Vancouver:
Chen J. Fabrication of metal-semiconductor materials by polydopamine and its application in SERS. [Internet] [Thesis]. NSYSU; 2016. [cited 2019 Oct 14].
Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0704116-111522.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Chen J. Fabrication of metal-semiconductor materials by polydopamine and its application in SERS. [Thesis]. NSYSU; 2016. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0704116-111522
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – San Diego
10.
Wang, Zhao.
Artificial Melanin: From Synthesis to Chemical Properties and Applications.
Degree: Chemistry, 2018, University of California – San Diego
URL: http://www.escholarship.org/uc/item/0w56j817
► Melanins are a class of naturally occurring pigments found throughout nature. They have gained great attention because it has a unique combination of properties functions…
(more)
▼ Melanins are a class of naturally occurring pigments found throughout nature. They have gained great attention because it has a unique combination of properties functions from metal ion chelation, photoprotection, free radical quenching, and coloration. We apply the synthetic chemistry combined with our increasing understanding of the natural systems to target, control, combine, and enhance the functionality of natural melanin, far beyond their natural capabilities. We term these nanostructures “Artificial Melanin”. Polydopamine (PDA), one type of synthetic melanin, reproduces essential properties of natural melanin. For example, PDA displays a keen ability to chelate various metal ions, making it a promising material for a wide range of applications, including in bioimaging, surface modification, electrocatalysis, batteries, and biosensing. We demonstrate that the introduction of metal to PDA can allow us to understand the effect of the spin centers towards the magnetic relaxation properties of a surrounding medium. These findings offer a guide to design more efficient contrast agents. For Chapter 2, we employ a synthetic method for drastically increasing and controlling the iron loading of artificial melanin particles to perform a quantitative investigation on the structure-property relationship by using a family of Fe(III)-chelated polydopamine nanoparticles doped with a tunable concentration of Fe(III) ions. A comprehensive analysis by magnetometry, electron paramagnetic resonance (EPR), and nuclear magnetic resonance dispersion (NMRD) demonstrates that the population of isolated Fe(III) centers dictates the degree of MRI contrast. These analyses allow prediction of the optimal Fe(III) loading via a quantitative modeling of antiferromagnetic coupling. These conclusions not only offer an intuitive understanding of the atomic origins of MRI contrast in complex polycatechol nanoparticles but also suggest future directions for the development of new enhanced MRI contrast agents. For Chapter 3, we synthesize metal-loaded polydopamine nanoparticles via autoxidation polymerization of dopamine in the presence of metal-dopamine complexes. Various metal ions including Mn(III), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Ga(III) ions could be incorporated into these artificial melanin nanoparticles with this strategy. We perform analysis on the doping range and parameters that affect the particles’ morphology. An investigation by magnetometry reveals general electronic structure and interactions for artificial melanin nanoparticles doped with Mn(III), Ni(II) and Co(II) ions. In addition, we compare the magnetic properties of high Mn(III)-loaded nanoparticles with Fe(III)-loaded nanoparticles to assess their potential as MRI contrast agents. For Chapter 4, we report the preparation artificial melanin nanoparticles with tunable Gadolinium loadings. These nanoparticles are analyzed by NMRD and with a 7 T magnetic resonance imaging (MRI) scanner. We observed a relaxivity of 75 mM−1 s −1 and 10.3 mM−1 s −1 at 1.4 T…
Subjects/Keywords: Chemistry; antiferromagnetic coupling; Melanin; Metal Coordination; MRI; Polydopamine; Relaxivity
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APA ·
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CSE |
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Manager
APA (6th Edition):
Wang, Z. (2018). Artificial Melanin: From Synthesis to Chemical Properties and Applications. (Thesis). University of California – San Diego. Retrieved from http://www.escholarship.org/uc/item/0w56j817
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wang, Zhao. “Artificial Melanin: From Synthesis to Chemical Properties and Applications.” 2018. Thesis, University of California – San Diego. Accessed October 14, 2019.
http://www.escholarship.org/uc/item/0w56j817.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wang, Zhao. “Artificial Melanin: From Synthesis to Chemical Properties and Applications.” 2018. Web. 14 Oct 2019.
Vancouver:
Wang Z. Artificial Melanin: From Synthesis to Chemical Properties and Applications. [Internet] [Thesis]. University of California – San Diego; 2018. [cited 2019 Oct 14].
Available from: http://www.escholarship.org/uc/item/0w56j817.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wang Z. Artificial Melanin: From Synthesis to Chemical Properties and Applications. [Thesis]. University of California – San Diego; 2018. Available from: http://www.escholarship.org/uc/item/0w56j817
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
NSYSU
11.
Li, Jun-sian.
The preparation of CaO nanoparticles and heavy metals adsorbent using Oyster Shells as green chemical source.
Degree: Master, Chemistry, 2017, NSYSU
URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0607117-160732
► In recent years, concern for the environment and interest in sustainable development has risen dramatically. Modern researchers now attempt to find solutions to difficult technical…
(more)
▼ In recent years, concern for the environment and interest in sustainable development has risen dramatically. Modern researchers now attempt to find solutions to difficult technical challenges using "green chemistry" processes and renewable materials. In this study, we use Oyster shell as a âgreenâ or natural material source to prepare three materials for use in several applications. This study is divided into two parts. In part 1, we prepared spherical calcium oxide nanoparticles (CaO-NPs) by hydrothermal synthesis in a sealed pressure vessel with water as the solvent. X-ray diffraction (XRD) was used to characterize the structure and transmission electron microscopy (TEM) to observe the CaO-NPs morphology. The CaO-NPs were approximately 40 nm in diameter and had a uniform dispersion. Additionally, we prepared silver/
polydopamine/calcium-oxide (Ag/PDA/CaO) samples for use as surface-enhanced Raman scattering (SERS) substrates and evaluated them using the probe molecule 4-aminothiophenil (4-ATP). Ag/PDA/CaO enhanced the 4-ATP signal and increased the detection limit up to 10-8 M. In part 2 of our study, we prepared Vaterite particles from oyster shell and tested their removal efficiency for different heavy metal ions. The results showed the removal efficiency was Pb2+ (99.9%), Cr3+ (99.5%), Fe3+ (99.3%) and Cu2+ (57.1%). We speculate that the ion exchange reaction between calcium ions and metal ions produces recrystallization which further affects the removal efficiency. Furthermore, the BET (Brunauer-Emmett-Teller) model shows that Vaterite particles are a giant pore adsorbent material that can rapidly adsorb large amounts of metal ions. In addition to the high efficiency heavy metal ion removal, the Vaterite particles are cheap and easy to synthesize (69% yield), thus providing a low cost and efficient alternative for industrial wastewater remediation.
Advisors/Committee Members: Chih-chung Wu (chair), Shu-ling Hsieh (chair), Shu-chen Hsieh (committee member).
Subjects/Keywords: CaO-NPs; CaCO3; silver nanoparticles; polydopamine; SERS; Oyster shell
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APA ·
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CSE |
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to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Li, J. (2017). The preparation of CaO nanoparticles and heavy metals adsorbent using Oyster Shells as green chemical source. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0607117-160732
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Li, Jun-sian. “The preparation of CaO nanoparticles and heavy metals adsorbent using Oyster Shells as green chemical source.” 2017. Thesis, NSYSU. Accessed October 14, 2019.
http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0607117-160732.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Li, Jun-sian. “The preparation of CaO nanoparticles and heavy metals adsorbent using Oyster Shells as green chemical source.” 2017. Web. 14 Oct 2019.
Vancouver:
Li J. The preparation of CaO nanoparticles and heavy metals adsorbent using Oyster Shells as green chemical source. [Internet] [Thesis]. NSYSU; 2017. [cited 2019 Oct 14].
Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0607117-160732.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Li J. The preparation of CaO nanoparticles and heavy metals adsorbent using Oyster Shells as green chemical source. [Thesis]. NSYSU; 2017. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0607117-160732
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – San Diego
12.
Huang, Yuran.
Multifunctional Polymeric Materials Programming Interfaces and Designed Artificial Melanosomes.
Degree: Materials Sci and Engineering, 2017, University of California – San Diego
URL: http://www.escholarship.org/uc/item/24n8t5ng
► The interfaces with micro/nanostructures in nature play important roles to bring in specific functions, which inspired and drove the development of novel nanostructures, including inorganic…
(more)
▼ The interfaces with micro/nanostructures in nature play important roles to bring in specific functions, which inspired and drove the development of novel nanostructures, including inorganic nanoparticles and organic nanoparticles. Among them, polymeric nanoparticles have been widely explored to programming interfaces because of the precise controlling in synthesis of polymers. Ring opening metathesis polymerization (ROMP) is a unique polymerization technique, which can incorporate versatile functional groups, tunable composition (hydrophobicity, molecular weight), and stimuli-responsiveness to endow various functionalities for the polymers, which have been explored for different application areas. In our research, we focused on designing and synthesizing multifunctional ROMP-based polymeric materials programming interfaces for different applications. For Chapter 2, we describe amphiphilic tri-block copolymers containing FeIII-catecholate complexes formulated as spherical- or cylindrical-shaped micellar nanoparticles (SMN and CMN respectively) as new T1-weighted agents with high relaxivity, low cytotoxicity, and long-term stability in biological fluids. Relaxivities of both SMN and CMN exceed those of established gadolinium chelates across a wide range of magnetic field strengths. Interestingly, shape-dependent behavior was observed in terms of the particles’ interactions with HeLa cells, with CMN exhibiting enhanced uptake and contrast via magnetic resonance imaging (MRI) compared with SMN. These results suggest that control over soft nanoparticle shape will provide an avenue for optimization of particle based contrast agents as biodiagnostics. We propose those polycatechol nanoparticles as suitable for pre-clinical investigations into their viability as gadolinium-free, safe and effective imaging agents for MRI contrast enhancement. For Chapter 3, we describe a method for the stabilization of low-boiling point (low-bp) perfluorocarbons (PFCs) at physiological temperatures by an amphiphilic triblock copolymer which can emulsify PFCs and be crosslinked. After UV-induced thiol-ene crosslinking, the core of the PFC emulsion remains in liquid form even at temperatures exceeding their boiling points. Critically, the formulation permits vaporization at rarefactional pressures relevant for clinical ultrasound. For Chapter 4, liquid crystals confined within micrometer-scale domains have been explored as the basis of a wide range of field- and stimuli-responsive materials for use in technologies spanning from biological sensors to electro-optical devices. We aim to build up a versatile stimuli-responsive polymeric surfactant to modulate the orientation of liquid crystal microdroplets. By incorporated different types of cleavable linkers into this system, we are able to endow versatile stimuli-responsiveness (UV, Redox, pH, ROS) in order to adapt to different certain circumstances. We proved that those cleavable linker-contained homopolymers were able to emulsify with liquid crystal droplets and generate radial…
Subjects/Keywords: Materials Science; Contrast agents; Imaging; Nanomaterials; polydopamine; Polymer
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Huang, Y. (2017). Multifunctional Polymeric Materials Programming Interfaces and Designed Artificial Melanosomes. (Thesis). University of California – San Diego. Retrieved from http://www.escholarship.org/uc/item/24n8t5ng
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Huang, Yuran. “Multifunctional Polymeric Materials Programming Interfaces and Designed Artificial Melanosomes.” 2017. Thesis, University of California – San Diego. Accessed October 14, 2019.
http://www.escholarship.org/uc/item/24n8t5ng.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Huang, Yuran. “Multifunctional Polymeric Materials Programming Interfaces and Designed Artificial Melanosomes.” 2017. Web. 14 Oct 2019.
Vancouver:
Huang Y. Multifunctional Polymeric Materials Programming Interfaces and Designed Artificial Melanosomes. [Internet] [Thesis]. University of California – San Diego; 2017. [cited 2019 Oct 14].
Available from: http://www.escholarship.org/uc/item/24n8t5ng.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Huang Y. Multifunctional Polymeric Materials Programming Interfaces and Designed Artificial Melanosomes. [Thesis]. University of California – San Diego; 2017. Available from: http://www.escholarship.org/uc/item/24n8t5ng
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
McMaster University
13.
Goh, Sharon.
Universal Aqueous-Based Antifouling Coatings for Multi-Material Devices.
Degree: MASc, 2017, McMaster University
URL: http://hdl.handle.net/11375/21453
► Biofouling is an ongoing problem in the development and usage of biomaterials for biomedical implants, microfluidic devices, and water-based sensors. Antifouling coatings involving surface modification…
(more)
▼ Biofouling is an ongoing problem in the development and usage of biomaterials for biomedical implants, microfluidic devices, and water-based sensors. Antifouling coatings involving surface modification of biomaterials is widely utilized to reduce unwanted protein adsorption and cell adhesion. Surface modification strategies, however, are reliant on the working material’s chemical properties. Thus, published procedures are often not applicable to a wide range of material classes. This constitutes a serious limitation in using surface modification on assembled multi-material devices, i.e on whole device modification. The objective of this research is to develop an antifouling coating with non-aggressive reaction conditions that can universally modify polymers and other material classes. Two strategies using polydopamine (PDA) as an anchor for polyethylene glycol (PEG) surface attachment were investigated: (1) PDA-PEG backfilled with bovine serum albumin (BSA), and (2) PDA-PEG with light activated perfluorophenyl azide (PFPA) conjugated to the PEG. Three materials varying in surface wettability were studied to evaluate the coatings for multi-material applications: porous polycarbonate membrane (PC), polydimethyl siloxane (PDMS), and soda lime glass cover slips.
Atomic force microscopy (AFM) and ellipsometry studies revealed substantial structural differences of PDA. Differences in PDA surface roughness affected PEG grafting in solution (the first method), with higher PEG coverage achieved on PC with intermediate surface roughness to PDMS and glass. Radiolabeled Fg adsorption and E. coli adhesion experiments showed reduced fouling on all PDA-PEG modified materials when backfilled with BSA. The ability for BSA to penetrate the PEG layer indicated that low PEG grafting densities were achieved using this grafting-to approach. The use of a photoactive labeling agent, PFPA, to tether PEG was proposed to improve PEG grafting on PDA. The PFPA-PEG modification protocol was optimized by quantifying Fg adsorption. Two treatments of PFPA-PEG were required to fully block PDA active sites. Fg adsorption was not significantly improved on PFPA-PEG modified PC and glass when backfilled with BSA, indicating sufficient PEG coverage of PDA. High Fg adsorption on PFPA-PEG surfaces indicate that high density PEG brushes were still not achieved with this method. PDMS surfaces were damaged with this procedure due to increased surface handling in the protocol. This is the first, to our knowledge, successful demonstration of PFPA modification on PDA surfaces. Photopatterning of polymer-based materials can be achieved, providing opportunities for utilising new materials in cell patterned platforms. Due to low PEG coverage on PDA surfaces from solution and using PFPA, ultra-low protein adsorption cannot be achieved using these aqueous-based methods. Antifouling modifications using PDA and PEG should be applied for short-term cell studies.
Thesis
Master of Applied Science (MASc)
Advisors/Committee Members: Fang, Qiyin, Brash, John, Biomedical Engineering.
Subjects/Keywords: Antifouling; Polyethylene Glycol; Bovine Serum Albumin; Polydopamine; Perfluorophenyl Azide
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Goh, S. (2017). Universal Aqueous-Based Antifouling Coatings for Multi-Material Devices. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/21453
Chicago Manual of Style (16th Edition):
Goh, Sharon. “Universal Aqueous-Based Antifouling Coatings for Multi-Material Devices.” 2017. Masters Thesis, McMaster University. Accessed October 14, 2019.
http://hdl.handle.net/11375/21453.
MLA Handbook (7th Edition):
Goh, Sharon. “Universal Aqueous-Based Antifouling Coatings for Multi-Material Devices.” 2017. Web. 14 Oct 2019.
Vancouver:
Goh S. Universal Aqueous-Based Antifouling Coatings for Multi-Material Devices. [Internet] [Masters thesis]. McMaster University; 2017. [cited 2019 Oct 14].
Available from: http://hdl.handle.net/11375/21453.
Council of Science Editors:
Goh S. Universal Aqueous-Based Antifouling Coatings for Multi-Material Devices. [Masters Thesis]. McMaster University; 2017. Available from: http://hdl.handle.net/11375/21453
University of Connecticut
14.
Russo, Jonathan L.
Inhibition of Urinary Tract Infections and Biofilm Formation on Long-term Indwelling Urethral Catheters through Antibacterial Coatings.
Degree: M. Eng., Biomedical Engineering, 2014, University of Connecticut
URL: https://opencommons.uconn.edu/gs_theses/573
► Indwelling urethral catheters are both important and convenient biomedical devices for many people. They provide incontinent and/or paraplegic patients an involuntary method of emptying…
(more)
▼ Indwelling urethral catheters are both important and convenient biomedical devices for many people. They provide incontinent and/or paraplegic patients an involuntary method of emptying their bladder. The catheters are inserted through the patient’s urethra to the posterior portion of the bladder. A balloon is inflated with water to keep it secure and in place. The tip of the catheter has an eye hole exposing the lumen of the catheter. The urine in the bladder drains through the lumen and out of the body into a collection bag. Catheters can potentially have 2 problems. First, they are prone to calcium/magnesium phosphate buildup on the surface and lumen of the catheter. This could obstruct the flow of urine making emptying the bladder difficult or impossible. Buildup on the surface of the catheter could also make removal of the catheter painful or even impossible without surgery. Secondly, catheters provide bacteria a route to travel to the kidneys to cause urinary tract infections. This could lead to long term problems such as chronic kidney disease.
The primary culprit for these infections is the bacterium
Proteus mirabilis. This bacteria has the ability to swarm on the catheter surface and travel to the bladder. It then secretes an enzyme called urease. This enzyme catalyzes a hydrolysis reaction converting urea into ammonia which eventually leads to nucleation of calcium and magnesium phosphate which can adhere to the catheter. The bacteria then differentiates into a swarmer bacteria and travels along the catheter surface to the kidneys where it causes urinary tract infections. The bacteria can easily adhere to hydrophilic surfaces and express factors to adhere to hydrophobic surfaces.
This research will aim to prevent these problems through the use of antibacterial coatings on the surface and lumen of the catheters. Different techniques were tested such as disrupting the bacterial membrane as well as inhibiting bacterial attachment altogether. These coatings should extend the indwelling time of catheters significantly. By inhibiting the bacteria, urinary tract infections and catheter encrustation will be significantly reduced compared to the current catheter designs. Surface characterization techniques and antibacterial assays were run to test the efficacy of the coatings.
Of six coatings that were tested, two were able to inhibit biofilm formation significantly better than the current commercially used method of silicone according to a crystal violet assay. One of the coatings, 11-mercapto-trimethylamine (11-MTA) was able to permeabalize very well killing over 90% of all bacteria on the surface. These results showed that amphiphillic cationic molecules are lethal to the membranes of gram-negative bacteria. During this research, a long term, and effective method was developed for preventing urinary tract infections and catheters encrustations for patients who use long term urethral catheters.
Advisors/Committee Members: Joerg Graf, Yu Lei, Mei Wei.
Subjects/Keywords: Polydimethylsiloxane; PDMS; catheter; polydopamine; antibacterial; antifouling; surface modification
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APA (6th Edition):
Russo, J. L. (2014). Inhibition of Urinary Tract Infections and Biofilm Formation on Long-term Indwelling Urethral Catheters through Antibacterial Coatings. (Masters Thesis). University of Connecticut. Retrieved from https://opencommons.uconn.edu/gs_theses/573
Chicago Manual of Style (16th Edition):
Russo, Jonathan L. “Inhibition of Urinary Tract Infections and Biofilm Formation on Long-term Indwelling Urethral Catheters through Antibacterial Coatings.” 2014. Masters Thesis, University of Connecticut. Accessed October 14, 2019.
https://opencommons.uconn.edu/gs_theses/573.
MLA Handbook (7th Edition):
Russo, Jonathan L. “Inhibition of Urinary Tract Infections and Biofilm Formation on Long-term Indwelling Urethral Catheters through Antibacterial Coatings.” 2014. Web. 14 Oct 2019.
Vancouver:
Russo JL. Inhibition of Urinary Tract Infections and Biofilm Formation on Long-term Indwelling Urethral Catheters through Antibacterial Coatings. [Internet] [Masters thesis]. University of Connecticut; 2014. [cited 2019 Oct 14].
Available from: https://opencommons.uconn.edu/gs_theses/573.
Council of Science Editors:
Russo JL. Inhibition of Urinary Tract Infections and Biofilm Formation on Long-term Indwelling Urethral Catheters through Antibacterial Coatings. [Masters Thesis]. University of Connecticut; 2014. Available from: https://opencommons.uconn.edu/gs_theses/573
Loughborough University
15.
Zhu, Bocheng.
Surface initiated polymerisation for applications in materials science.
Degree: 2012, Loughborough University
URL: https://dspace.lboro.ac.uk/2134/10858
;
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.561175
► A systematic study of the surface-initiated polymerisation kinetics of a relatively new type of atom transfer radical polymerisation (ATRP), activators regenerated by electron transfer (ARGET)…
(more)
▼ A systematic study of the surface-initiated polymerisation kinetics of a relatively new type of atom transfer radical polymerisation (ATRP), activators regenerated by electron transfer (ARGET) ATRP, is first demonstrated in this report. Poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(methyl methacrylate) (PMMA) were successfully grown from silicon surfaces at room temperature by surface-initiated ARGET ATRP using a "3rd generation" cationic macroinitiator. The polymer films were analysed by ellipsometry, X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR). With the initial experiment showing that water accelerated conventional ATRP but made it less controlled, the effect of solvent on ARGET ATRP was also evaluated. The living character of ARGET ATRP was demonstrated by successfully reinitiating PHEMA-grafted silicon wafers to grow a second block of PHEMA. Initiator density was shown to have a great effect on the growth rate of PHEMA film thickness on silicon surfaces by comparing the ARGET ATRP growth of PHEMA films using two different initiators, "1st generation" and "3rd generation" cationic macroinitiators, which have different ratios of initiating groups to positive charge. Another type of initiator for ATRP systems, an amide silane, was then investigated as an alternative to polyelectrolyte macroinitiators to avoid degrafting. The effects of solvent, 2, 2′ bipyridyl (bpy) ligand concentration and different types of reducing agent on the growth of PHEMA film from amide-initiator coated silicon wafers by ARGET ATRP were then explored at room temperature. However, it was found that the swings in the uncontrolled laboratory ambient temperature caused inter-sample and inter-experiment variability and so could make the evaluations inaccurate or even wrong. An investigation of temperature on ARGET ATRP showed a dramatic effect on the polymerisation rate. The higher the temperature, the faster the polymerisation proceeded. Therefore, the effects of solvent, ratio of bpy to Cu and reducing agent on the ARGET ATRP growth of PHEMA brushes from amide initiator-coated silicon wafers were re-evaluated at a constant temperature, 30 °C. The development of a polydopamine-based initiator, which was designed to be able to be immobilised on a wide range of surfaces, is then presented in this report. Polydopamine was first shown to be able to deposit on various types of material surfaces by oxidative polymerisation in aqueous solution. Bromoester initiating groups for ATRP systems were incorporated into polydopamine coatings by reacting a fraction of the dopamine monomer with 2-bromoisobutyryl bromide (BIBB) before polymerisation. The modified polydopamine initiator film grew at a comparable rate to unmodified polydopamine, with a 45 nm being grown in 24 hours. Successful incorporation of initiator groups was confirmed by XPS and FTIR, and by the growth of PMMA and PHEMA polymer brushes by ARGET ATRP from the polydopamine initiator coatings. A PMMA brush with a thickness of 239 nm was grown…
Subjects/Keywords: 620.11; Surface-initiated polymerisation; Polymer brushes; Polydopamine; Surface-independent initiator; Interfacial adhesion
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APA (6th Edition):
Zhu, B. (2012). Surface initiated polymerisation for applications in materials science. (Doctoral Dissertation). Loughborough University. Retrieved from https://dspace.lboro.ac.uk/2134/10858 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.561175
Chicago Manual of Style (16th Edition):
Zhu, Bocheng. “Surface initiated polymerisation for applications in materials science.” 2012. Doctoral Dissertation, Loughborough University. Accessed October 14, 2019.
https://dspace.lboro.ac.uk/2134/10858 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.561175.
MLA Handbook (7th Edition):
Zhu, Bocheng. “Surface initiated polymerisation for applications in materials science.” 2012. Web. 14 Oct 2019.
Vancouver:
Zhu B. Surface initiated polymerisation for applications in materials science. [Internet] [Doctoral dissertation]. Loughborough University; 2012. [cited 2019 Oct 14].
Available from: https://dspace.lboro.ac.uk/2134/10858 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.561175.
Council of Science Editors:
Zhu B. Surface initiated polymerisation for applications in materials science. [Doctoral Dissertation]. Loughborough University; 2012. Available from: https://dspace.lboro.ac.uk/2134/10858 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.561175
NSYSU
16.
Lin, Jia-hui.
Development of molecular- and nanomaterial-based probes for sensing biomolecules and metal ions.
Degree: PhD, Chemistry, 2015, NSYSU
URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0104115-131206
► The purpose of this thesis is to describe how to develop molecular- and nanomaterial-based biosensor for sensing biomolecules and metal ions. The thesis consists of…
(more)
▼ The purpose of this thesis is to describe how to develop molecular- and nanomaterial-based biosensor for sensing biomolecules and metal ions. The thesis consists of four independent works. (1) A simple and label-free fluorescent method for sensitive and selective detection of adenosine in urine sample was developed based on adenosine-induced inhibition of adenosylhomocysteine hydrolase (SAHH) activity. Without the addition of nucleophile, 2,3-naphthalenedicarboxaldehyde (NDA) was found to selectively react with homocysteine to form fluorescent product. Adenosine is efficient to inhibit the production of homocysteine from the hydrolysis reaction between SAHH and adenosylhomocysteine. Taken together, the fluorescence of NDA-homocysteine derivatives decreased with an increase in the adenosine concentration. As a result, the SAHH-based probe provided high sensitivity (a limit of detection for adenosine of 0.3 μM) and high selectivity (more than 100-fold for andenosine over any adenosine analogs). (2) A set of two-input and three-input DNA logic gates was constructed using non-Waston-Crick base pairing-based molecular beacon (MB). The presence of Hg2+, Ag+, and coralyne promoted the conformational changes of MB via the formation of T-Hg2+-T, C-Ag+-C, and A2-coralyne-A2 coordination, resulting in its fluorescent quenching. It was found that thiols, complexing agents, and polyadenosine can remove Hg2+, Ag+, and coralyne from the hairpin-shaped MB, respectively. Based on these phenomenon, the designed MB generated a series of two-input, three-input, and set-reset logic operation at the molecular level. (3) Laser-induced light scattering technique with the adevantages of high sensitivity, low cost, portability, and miniaturization was applied for sensing three gold nanoparticle-based sensing systems, including salt-, thiol-, and metal ion-induced nanoparticle aggregation. The combination of a miniatuarized spectrometer with a 532-nm laser allows the sensitive detection of Rayleigh scattering from nanoparticles aggregation. As a result, the proposed system provided more than 10-fold sensitivity improvement as compared to colorimetric assay. (4) Fluorescent
polydopamine particles was prepared through hydroxyl-radical degradation of
polydopamine nanoparticles. The production of fluorescent
polydopamine was demonstrated using transmission electron microscope, dark field microscope, and thermogravimetric analyzer. The possible chemical compositions of
polydopamine dots were determined using Fourier transform infrared spectrosmeter and laser desorption/ionization-time-of-flight mass spectrometer. Additionally, fluorescent
polydopamine dots were used for sensitive and selective detection of Fe(III) through coordination between the catechol group of fluorescent
polydopamine dots and Fe(III). This sensing mechanism relied on electron-transfer-induced fluorescence quenching.
Advisors/Committee Members: Po-Chiao Lin (chair), Yang-Hsiang Chan (chair), Shou-Mei Wu (chair), Shiuh-jen Jiang (chair), Wei-Lung Tseng (committee member).
Subjects/Keywords: inhibition; derivatization; molecular logic gates; molecular beacon; gold nanoparticles; light scattering; fluorescent polydopamine
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APA ·
Chicago ·
MLA ·
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CSE |
Export
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APA (6th Edition):
Lin, J. (2015). Development of molecular- and nanomaterial-based probes for sensing biomolecules and metal ions. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0104115-131206
Chicago Manual of Style (16th Edition):
Lin, Jia-hui. “Development of molecular- and nanomaterial-based probes for sensing biomolecules and metal ions.” 2015. Doctoral Dissertation, NSYSU. Accessed October 14, 2019.
http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0104115-131206.
MLA Handbook (7th Edition):
Lin, Jia-hui. “Development of molecular- and nanomaterial-based probes for sensing biomolecules and metal ions.” 2015. Web. 14 Oct 2019.
Vancouver:
Lin J. Development of molecular- and nanomaterial-based probes for sensing biomolecules and metal ions. [Internet] [Doctoral dissertation]. NSYSU; 2015. [cited 2019 Oct 14].
Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0104115-131206.
Council of Science Editors:
Lin J. Development of molecular- and nanomaterial-based probes for sensing biomolecules and metal ions. [Doctoral Dissertation]. NSYSU; 2015. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0104115-131206
17.
LYU QINGHUA.
TOWARDS THE DEVELOPMENT OF BIOMIMETIC MATERIALS FOR POTENTIAL BIOMEDICAL APPLICATIONS: AN INVESTIGATION ON CATECHOLAMINES-BASED COATINGS FOR SURFACE FUNCTIONALIZATION.
Degree: 2018, National University of Singapore
URL: https://scholarbank.nus.edu.sg/handle/10635/155544
Subjects/Keywords: surface coatings; biomimetic; catechol; catecholamine; polydopamine
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APA ·
Chicago ·
MLA ·
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CSE |
Export
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APA (6th Edition):
QINGHUA, L. (2018). TOWARDS THE DEVELOPMENT OF BIOMIMETIC MATERIALS FOR POTENTIAL BIOMEDICAL APPLICATIONS: AN INVESTIGATION ON CATECHOLAMINES-BASED COATINGS FOR SURFACE FUNCTIONALIZATION. (Thesis). National University of Singapore. Retrieved from https://scholarbank.nus.edu.sg/handle/10635/155544
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
QINGHUA, LYU. “TOWARDS THE DEVELOPMENT OF BIOMIMETIC MATERIALS FOR POTENTIAL BIOMEDICAL APPLICATIONS: AN INVESTIGATION ON CATECHOLAMINES-BASED COATINGS FOR SURFACE FUNCTIONALIZATION.” 2018. Thesis, National University of Singapore. Accessed October 14, 2019.
https://scholarbank.nus.edu.sg/handle/10635/155544.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
QINGHUA, LYU. “TOWARDS THE DEVELOPMENT OF BIOMIMETIC MATERIALS FOR POTENTIAL BIOMEDICAL APPLICATIONS: AN INVESTIGATION ON CATECHOLAMINES-BASED COATINGS FOR SURFACE FUNCTIONALIZATION.” 2018. Web. 14 Oct 2019.
Vancouver:
QINGHUA L. TOWARDS THE DEVELOPMENT OF BIOMIMETIC MATERIALS FOR POTENTIAL BIOMEDICAL APPLICATIONS: AN INVESTIGATION ON CATECHOLAMINES-BASED COATINGS FOR SURFACE FUNCTIONALIZATION. [Internet] [Thesis]. National University of Singapore; 2018. [cited 2019 Oct 14].
Available from: https://scholarbank.nus.edu.sg/handle/10635/155544.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
QINGHUA L. TOWARDS THE DEVELOPMENT OF BIOMIMETIC MATERIALS FOR POTENTIAL BIOMEDICAL APPLICATIONS: AN INVESTIGATION ON CATECHOLAMINES-BASED COATINGS FOR SURFACE FUNCTIONALIZATION. [Thesis]. National University of Singapore; 2018. Available from: https://scholarbank.nus.edu.sg/handle/10635/155544
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Loughborough University
18.
Zhu, Bocheng.
Surface initiated polymerisation for applications in materials science.
Degree: PhD, 2012, Loughborough University
URL: http://hdl.handle.net/2134/10858
► A systematic study of the surface-initiated polymerisation kinetics of a relatively new type of atom transfer radical polymerisation (ATRP), activators regenerated by electron transfer (ARGET)…
(more)
▼ A systematic study of the surface-initiated polymerisation kinetics of a relatively new type of atom transfer radical polymerisation (ATRP), activators regenerated by electron transfer (ARGET) ATRP, is first demonstrated in this report. Poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(methyl methacrylate) (PMMA) were successfully grown from silicon surfaces at room temperature by surface-initiated ARGET ATRP using a "3rd generation" cationic macroinitiator. The polymer films were analysed by ellipsometry, X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR). With the initial experiment showing that water accelerated conventional ATRP but made it less controlled, the effect of solvent on ARGET ATRP was also evaluated. The living character of ARGET ATRP was demonstrated by successfully reinitiating PHEMA-grafted silicon wafers to grow a second block of PHEMA. Initiator density was shown to have a great effect on the growth rate of PHEMA film thickness on silicon surfaces by comparing the ARGET ATRP growth of PHEMA films using two different initiators, "1st generation" and "3rd generation" cationic macroinitiators, which have different ratios of initiating groups to positive charge. Another type of initiator for ATRP systems, an amide silane, was then investigated as an alternative to polyelectrolyte macroinitiators to avoid degrafting. The effects of solvent, 2, 2′ bipyridyl (bpy) ligand concentration and different types of reducing agent on the growth of PHEMA film from amide-initiator coated silicon wafers by ARGET ATRP were then explored at room temperature. However, it was found that the swings in the uncontrolled laboratory ambient temperature caused inter-sample and inter-experiment variability and so could make the evaluations inaccurate or even wrong. An investigation of temperature on ARGET ATRP showed a dramatic effect on the polymerisation rate. The higher the temperature, the faster the polymerisation proceeded. Therefore, the effects of solvent, ratio of bpy to Cu and reducing agent on the ARGET ATRP growth of PHEMA brushes from amide initiator-coated silicon wafers were re-evaluated at a constant temperature, 30 °C. The development of a polydopamine-based initiator, which was designed to be able to be immobilised on a wide range of surfaces, is then presented in this report. Polydopamine was first shown to be able to deposit on various types of material surfaces by oxidative polymerisation in aqueous solution. Bromoester initiating groups for ATRP systems were incorporated into polydopamine coatings by reacting a fraction of the dopamine monomer with 2-bromoisobutyryl bromide (BIBB) before polymerisation. The modified polydopamine initiator film grew at a comparable rate to unmodified polydopamine, with a 45 nm being grown in 24 hours. Successful incorporation of initiator groups was confirmed by XPS and FTIR, and by the growth of PMMA and PHEMA polymer brushes by ARGET ATRP from the polydopamine initiator coatings. A PMMA brush with a thickness of 239 nm was grown…
Subjects/Keywords: 620.11; Surface-initiated polymerisation; Polymer brushes; Polydopamine; Surface-independent initiator; Interfacial adhesion
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APA ·
Chicago ·
MLA ·
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CSE |
Export
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Manager
APA (6th Edition):
Zhu, B. (2012). Surface initiated polymerisation for applications in materials science. (Doctoral Dissertation). Loughborough University. Retrieved from http://hdl.handle.net/2134/10858
Chicago Manual of Style (16th Edition):
Zhu, Bocheng. “Surface initiated polymerisation for applications in materials science.” 2012. Doctoral Dissertation, Loughborough University. Accessed October 14, 2019.
http://hdl.handle.net/2134/10858.
MLA Handbook (7th Edition):
Zhu, Bocheng. “Surface initiated polymerisation for applications in materials science.” 2012. Web. 14 Oct 2019.
Vancouver:
Zhu B. Surface initiated polymerisation for applications in materials science. [Internet] [Doctoral dissertation]. Loughborough University; 2012. [cited 2019 Oct 14].
Available from: http://hdl.handle.net/2134/10858.
Council of Science Editors:
Zhu B. Surface initiated polymerisation for applications in materials science. [Doctoral Dissertation]. Loughborough University; 2012. Available from: http://hdl.handle.net/2134/10858
McMaster University
19.
Truong, Tich.
THE SPICY, THE EVERLASTING AND THE UNEXPECTED: INVESTIGATING THREE COMPOUNDS THAT SUPPRESS MACROPHAGES AND MYOFIBROBLASTS TO REDUCE BIOMATERIAL-INDUCED FIBROSIS.
Degree: MASc, 2017, McMaster University
URL: http://hdl.handle.net/11375/20987
► Capsaicin, prostaglandin E2 (PGE2) and polydopamine (PDA) were used to target macrophage and myofibroblast activity to reduce biomaterial-induced fibrosis. The lifetime and efficacy of implantable…
(more)
▼ Capsaicin, prostaglandin E2 (PGE2) and polydopamine (PDA) were used to target macrophage and myofibroblast activity to reduce biomaterial-induced fibrosis. The lifetime and efficacy of implantable biomedical devices are determined by the foreign body response. Immediately after implantation, proteins nonspecifically adsorb onto the material and initiate inflammation. Macrophages recruited to the site can differentiate into M1 and M2 phenotypes and upregulate inflammation and fibrosis which interferes with the intended function. M1 macrophages secrete pro-inflammatory mediators that induce chronic inflammation and promote myofibroblast differentiation while M2 macrophages are wound healing cells that suppress inflammation and regulate fibroblast activity. The fibrotic tissue is developed by myofibroblasts which produce collagen in an unregulated fashion. Collagen thickening and biomaterial encapsulation decreases efficacy and sensitive of biomedical devices. We investigated the in vitro and in vivo effects of capsaicin, PGE2 and polydopamine surface modification on macrophages and myofibroblasts. Capsaicin and PGE2 reduced poly(lactic-co-glycolic) acid (PLGA)-induced fibrosis by promoting M2 macrophage phenotype to secrete anti-inflammatory IL-10 and suppressing myofibroblast marker α-smooth muscle actin (α-SMA). Capsaicin decreased collagen by 40% and upregulated IL-10 secretion by 35% while PGE2 reduced collagen by 55% after 14 days of implantation and 40% less collagen after 42 days. PDA was used to bind an anti-fibrotic compound to the surface of a poly(dimethyl siloxane) (PDMS-PDA) to reduce fibrosis. However, PDMS-PDA controls gave an unexpected result by reducing fibrosis to the same extent as anti-fibrotic compound bound PDMS-
v
PDA. PDA modification reduced cellularity by 50% and significantly decreased collagen thickness by 30%. Overall, our results showed that biomaterial-induced fibrosis can be reduced by promoting M2 macrophage activity and inhibiting myofibroblast differentiation. This research demonstrates three compounds that have potential to reduce fibrosis and extend the lifetime and efficacy of implantable biomedical devices.
Thesis
Master of Applied Science (MASc)
Capsaicin, prostaglandin E2 (PGE2) and polydopamine were used to reduce scar tissue development around implanted polymers. Biomedical devices implanted in the body can undergo severe scar tissue formation, or fibrosis, and fail. Fibrosis is described by the accumulation of collagen and encapsulation of an implanted polymer. Macrophages regulate fibrosis by secreting pro-fibrotic compounds and myofibroblasts produce unregulated amounts of collagen. In this thesis, capsaicin, PGE2 and polydopamine were incorporated into implants to target macrophage and myofibroblast activity and reduce fibrosis in mice. Capsaicin and PGE2, released from a degradable polymer, altered macrophages to secrete anti-fibrotic compounds and decreased collagen by 40% and 55%, respectively. Polydopamine surface modified implants gave an unexpected result…
Advisors/Committee Members: Jones, Kim, Chemical Engineering.
Subjects/Keywords: capsaicin; macrophage phenotype; fibrosis; poly(lactic-co-glycolic) acid (PLGA); myofibroblast; inflammation; polydimethylsiloxane; polydopamine; fibrinogen; prostaglandin E2 (PGE2)
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Truong, T. (2017). THE SPICY, THE EVERLASTING AND THE UNEXPECTED: INVESTIGATING THREE COMPOUNDS THAT SUPPRESS MACROPHAGES AND MYOFIBROBLASTS TO REDUCE BIOMATERIAL-INDUCED FIBROSIS. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/20987
Chicago Manual of Style (16th Edition):
Truong, Tich. “THE SPICY, THE EVERLASTING AND THE UNEXPECTED: INVESTIGATING THREE COMPOUNDS THAT SUPPRESS MACROPHAGES AND MYOFIBROBLASTS TO REDUCE BIOMATERIAL-INDUCED FIBROSIS.” 2017. Masters Thesis, McMaster University. Accessed October 14, 2019.
http://hdl.handle.net/11375/20987.
MLA Handbook (7th Edition):
Truong, Tich. “THE SPICY, THE EVERLASTING AND THE UNEXPECTED: INVESTIGATING THREE COMPOUNDS THAT SUPPRESS MACROPHAGES AND MYOFIBROBLASTS TO REDUCE BIOMATERIAL-INDUCED FIBROSIS.” 2017. Web. 14 Oct 2019.
Vancouver:
Truong T. THE SPICY, THE EVERLASTING AND THE UNEXPECTED: INVESTIGATING THREE COMPOUNDS THAT SUPPRESS MACROPHAGES AND MYOFIBROBLASTS TO REDUCE BIOMATERIAL-INDUCED FIBROSIS. [Internet] [Masters thesis]. McMaster University; 2017. [cited 2019 Oct 14].
Available from: http://hdl.handle.net/11375/20987.
Council of Science Editors:
Truong T. THE SPICY, THE EVERLASTING AND THE UNEXPECTED: INVESTIGATING THREE COMPOUNDS THAT SUPPRESS MACROPHAGES AND MYOFIBROBLASTS TO REDUCE BIOMATERIAL-INDUCED FIBROSIS. [Masters Thesis]. McMaster University; 2017. Available from: http://hdl.handle.net/11375/20987
Michigan Technological University
20.
Sharma, Dhavan D.
EFFECTS OF TOPOGRAPHICAL FEATURES ON MICROVASCULAR NETWORK FORMATION.
Degree: MS, Department of Biomedical Engineering, 2018, Michigan Technological University
URL: https://digitalcommons.mtu.edu/etdr/682
► Current advancements in tissue engineering and biomaterials have inspired researchers to develop highly biomimetic tissues including vascular grafts, cardiac patches, skin substitutes, bone tissues…
(more)
▼ Current advancements in tissue engineering and biomaterials have inspired researchers to develop highly biomimetic tissues including vascular grafts, cardiac patches, skin substitutes, bone tissues etc. All of these tissues in their natural form contains highly organized microfluidic network composed of blood vessels, capillaries and lymphatics. Vascular network is one the crucial component in tissue architecture that maintains exchange of gases, nutrients and metabolic byproducts. Importantly, engineered tissues having thickness greater than 150-200 μm cannot rely upon diffusive nutrient transport after implantation. Therefore, one of the biggest obstacle in current scenario is to develop vascular networks in engineered tissues that can perfuse with host vasculature. Several approaches have been tested in past to develop microvacular network
in vitro. These include external provision of angiogenic growth factors or appropriate extracellular matrix (ECM) proteins that stimulate endothelial cells (ECs) to form pro-angiogenic vascular networks. Interestingly, a completely fascinating avenue of topographical stimulation is still needs to be explored in order to determine its potential to stimulate angiogenesis. The objective of this study was to develop
de novo microvascular network
in vitro by Human mesenchymal stem cell (hMSC)- EC co-culture and investigate influence of micron scale topographical features on characteristics of this microvascular network. To achieve this goal, we tested mussel inspired
polydopamine (PD) based coating to improve polydimethylsiloxane (PDMS) surface properties for optimum cell attachment and spreading. Our results indicated that micron scale topographical features have significant influence on properties of microvascular network including vessel alignment, intercapillary distance and vessel length.
Advisors/Committee Members: Feng Zhao.
Subjects/Keywords: Surface topography; vascular networks; tissue engineering; polydimethylsiloxane; polydopamine; human mesenchymal stem cells; Molecular, Cellular, and Tissue Engineering
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APA ·
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APA (6th Edition):
Sharma, D. D. (2018). EFFECTS OF TOPOGRAPHICAL FEATURES ON MICROVASCULAR NETWORK FORMATION. (Masters Thesis). Michigan Technological University. Retrieved from https://digitalcommons.mtu.edu/etdr/682
Chicago Manual of Style (16th Edition):
Sharma, Dhavan D. “EFFECTS OF TOPOGRAPHICAL FEATURES ON MICROVASCULAR NETWORK FORMATION.” 2018. Masters Thesis, Michigan Technological University. Accessed October 14, 2019.
https://digitalcommons.mtu.edu/etdr/682.
MLA Handbook (7th Edition):
Sharma, Dhavan D. “EFFECTS OF TOPOGRAPHICAL FEATURES ON MICROVASCULAR NETWORK FORMATION.” 2018. Web. 14 Oct 2019.
Vancouver:
Sharma DD. EFFECTS OF TOPOGRAPHICAL FEATURES ON MICROVASCULAR NETWORK FORMATION. [Internet] [Masters thesis]. Michigan Technological University; 2018. [cited 2019 Oct 14].
Available from: https://digitalcommons.mtu.edu/etdr/682.
Council of Science Editors:
Sharma DD. EFFECTS OF TOPOGRAPHICAL FEATURES ON MICROVASCULAR NETWORK FORMATION. [Masters Thesis]. Michigan Technological University; 2018. Available from: https://digitalcommons.mtu.edu/etdr/682
Université du Québec à Montréal
21.
Nirasay, Souryvanh.
Élaboration de membranes phospholipidiques supportées sur des surfaces nanopatternées en vue d'améliorer le criblage des médicaments.
Degree: 2017, Université du Québec à Montréal
URL: http://archipel.uqam.ca/10485/1/D3279.pdf
► Les bicouches lipidiques supportées sur surface solide (s-SLBs) sont largement utilisées pour mimer les membranes biologiques. Elles consistent en une bicouche lipidique continue déposée directement…
(more)
▼ Les bicouches lipidiques supportées sur surface solide (s-SLBs) sont largement utilisées pour mimer les membranes biologiques. Elles consistent en une bicouche lipidique continue déposée directement sur un support solide. Cependant, l'existence d'interactions lipide-solide entraîne une perte de la mobilité des lipides et une diminution de la fluidité naturelle des membranes. Un modèle satisfaisant devrait inclure un recouvrement de surface par la bicouche sur de larges régions ainsi que le maintien de la mobilité latérale des lipides, d'une importance déterminante pour garantir un modèle pertinent des biomembranes. La première partie de cette recherche visait à résoudre ce problème en élaborant un modèle de bicouche lipidique supportée par un coussin polymère (p-SLB), dans lequel le polymère agirait en tant que couche lubrifiante entre la membrane et le support solide. Le polymère bioinspiré polydopamine (PDA) a été choisi en raison de son aptitude à former facilement des revêtements minces sur une grande variété de surfaces, avec un contrôle de l'épaisseur en fonction du temps d'immersion du substrat. La caractérisation du polymère a été réalisée par des mesures d'angle de contact, spectroscopie photoélectronique par rayons X (XPS), ellipsométrie et microscopie à force atomique (AFM). Une surface de mica modifié avec la PDA a été utilisée pour supporter des bicouches de phospholipides zwitterioniques de dimyristoylphosphatidylcholine (DMPC) ou dioléoylphosphatidylcholine (DOPC) ; la phosphatidylcholine étant le phospholipide le plus abondant dans les membranes des cellules eucaryotes. Cependant, la caractérisation par AFM a révélé la formation de patches lipidiques sur la PDA au lieu d'une bicouche continue. Sur la base de considérations électrostatiques, nous avons incorporé un lipide cationique, le 3ß-[N-(N',N'-diméthylaminoéthane) carbamoyl]cholestérol (DC-Chol) dans la composition liposomale afin d'attirer davantage de vésicules à la surface de PDA chargée négativement et ainsi favoriser les interactions vésicules-polymère au cours du processus de fusion de vésicules. Nous avons de nouveau utilisé l'imagerie d'AFM ainsi que des techniques de caractérisation de surface telles que la résonance des plasmons de surface (SPR) et la Microbalance à cristal de quartz avec Dissipation (QCM-D) pour examiner davantage la formation des membranes à la surface du polymère. La microscopie de fluorescence via des expériences de FRAP a été utilisée pour évaluer la mobilité des phospholipides. Les résultats ont prouvé que notre stratégie permettait l'obtention d'une bicouche continue avec plus de 90 % de la surface polymère recouverte par une membrane de DOPC/DC-Chol (70/30). Le film de PDA s'est également avéré efficace pour maintenir la fluidité des bicouches phospholipidiques, améliorant ainsi cette classe de membrane modèle. Le second objectif de cette recherche fut de développer un modèle amélioré du test Parallel Artificial Membrane Permeability Assay (PAMPA). Les tests PAMPA sont largement utilisés dans l'industrie…
Subjects/Keywords: Membranes lipidiques bimoléculaires; Phospholipides; Polydopamine; Polymères biomimétiques; Nanomatériaux; Parallel Artificial Membrane Permeability Assay (PAMPA); Criblage à haut débit
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APA (6th Edition):
Nirasay, S. (2017). Élaboration de membranes phospholipidiques supportées sur des surfaces nanopatternées en vue d'améliorer le criblage des médicaments. (Thesis). Université du Québec à Montréal. Retrieved from http://archipel.uqam.ca/10485/1/D3279.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Nirasay, Souryvanh. “Élaboration de membranes phospholipidiques supportées sur des surfaces nanopatternées en vue d'améliorer le criblage des médicaments.” 2017. Thesis, Université du Québec à Montréal. Accessed October 14, 2019.
http://archipel.uqam.ca/10485/1/D3279.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Nirasay, Souryvanh. “Élaboration de membranes phospholipidiques supportées sur des surfaces nanopatternées en vue d'améliorer le criblage des médicaments.” 2017. Web. 14 Oct 2019.
Vancouver:
Nirasay S. Élaboration de membranes phospholipidiques supportées sur des surfaces nanopatternées en vue d'améliorer le criblage des médicaments. [Internet] [Thesis]. Université du Québec à Montréal; 2017. [cited 2019 Oct 14].
Available from: http://archipel.uqam.ca/10485/1/D3279.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Nirasay S. Élaboration de membranes phospholipidiques supportées sur des surfaces nanopatternées en vue d'améliorer le criblage des médicaments. [Thesis]. Université du Québec à Montréal; 2017. Available from: http://archipel.uqam.ca/10485/1/D3279.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
22.
BARBARA ELODIE ARIANE POINARD.
POLYDOPAMINE NANOPARTICLES AS A MUCOPENETRATIVE DRUG DELIVERY NANOCARRIER FOR BLADDER CANCER TREATMENT.
Degree: 2018, National University of Singapore
URL: http://scholarbank.nus.edu.sg/handle/10635/150963
Subjects/Keywords: Nanoparticles; Polydopamine; Bladder Cancer; Mucopenetration; Photodynamic therapy; Photothermal therapy
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APA (6th Edition):
POINARD, B. E. A. (2018). POLYDOPAMINE NANOPARTICLES AS A MUCOPENETRATIVE DRUG DELIVERY NANOCARRIER FOR BLADDER CANCER TREATMENT. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/150963
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
POINARD, BARBARA ELODIE ARIANE. “POLYDOPAMINE NANOPARTICLES AS A MUCOPENETRATIVE DRUG DELIVERY NANOCARRIER FOR BLADDER CANCER TREATMENT.” 2018. Thesis, National University of Singapore. Accessed October 14, 2019.
http://scholarbank.nus.edu.sg/handle/10635/150963.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
POINARD, BARBARA ELODIE ARIANE. “POLYDOPAMINE NANOPARTICLES AS A MUCOPENETRATIVE DRUG DELIVERY NANOCARRIER FOR BLADDER CANCER TREATMENT.” 2018. Web. 14 Oct 2019.
Vancouver:
POINARD BEA. POLYDOPAMINE NANOPARTICLES AS A MUCOPENETRATIVE DRUG DELIVERY NANOCARRIER FOR BLADDER CANCER TREATMENT. [Internet] [Thesis]. National University of Singapore; 2018. [cited 2019 Oct 14].
Available from: http://scholarbank.nus.edu.sg/handle/10635/150963.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
POINARD BEA. POLYDOPAMINE NANOPARTICLES AS A MUCOPENETRATIVE DRUG DELIVERY NANOCARRIER FOR BLADDER CANCER TREATMENT. [Thesis]. National University of Singapore; 2018. Available from: http://scholarbank.nus.edu.sg/handle/10635/150963
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
23.
LEWIS TAN HARK CHUAN.
SURFACE MODIFICATION OF METALLIC ORTHOPAEDIC IMPLANTS TO ENHANCE ANTI-FIBROTIC AND ANTI-INFLAMMATORY EFFECTS USING BMP-7 DERIVATIVES.
Degree: 2013, National University of Singapore
URL: http://scholarbank.nus.edu.sg/handle/10635/48865
Subjects/Keywords: fibrosis; cobalt-chromium; inflammation; BMP-7; polydopamine; osteogenesis
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APA (6th Edition):
CHUAN, L. T. H. (2013). SURFACE MODIFICATION OF METALLIC ORTHOPAEDIC IMPLANTS TO ENHANCE ANTI-FIBROTIC AND ANTI-INFLAMMATORY EFFECTS USING BMP-7 DERIVATIVES. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/48865
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
CHUAN, LEWIS TAN HARK. “SURFACE MODIFICATION OF METALLIC ORTHOPAEDIC IMPLANTS TO ENHANCE ANTI-FIBROTIC AND ANTI-INFLAMMATORY EFFECTS USING BMP-7 DERIVATIVES.” 2013. Thesis, National University of Singapore. Accessed October 14, 2019.
http://scholarbank.nus.edu.sg/handle/10635/48865.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
CHUAN, LEWIS TAN HARK. “SURFACE MODIFICATION OF METALLIC ORTHOPAEDIC IMPLANTS TO ENHANCE ANTI-FIBROTIC AND ANTI-INFLAMMATORY EFFECTS USING BMP-7 DERIVATIVES.” 2013. Web. 14 Oct 2019.
Vancouver:
CHUAN LTH. SURFACE MODIFICATION OF METALLIC ORTHOPAEDIC IMPLANTS TO ENHANCE ANTI-FIBROTIC AND ANTI-INFLAMMATORY EFFECTS USING BMP-7 DERIVATIVES. [Internet] [Thesis]. National University of Singapore; 2013. [cited 2019 Oct 14].
Available from: http://scholarbank.nus.edu.sg/handle/10635/48865.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
CHUAN LTH. SURFACE MODIFICATION OF METALLIC ORTHOPAEDIC IMPLANTS TO ENHANCE ANTI-FIBROTIC AND ANTI-INFLAMMATORY EFFECTS USING BMP-7 DERIVATIVES. [Thesis]. National University of Singapore; 2013. Available from: http://scholarbank.nus.edu.sg/handle/10635/48865
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of New South Wales
24.
Le-Masurier, Solomon.
Polydopamine coated substrates as scaffolds for glycopolymer brushes attached via one-pot 'grafting from' synthesis and para-fluoro 'click chemistry' for biomedical applications.
Degree: Centre for Advanced Macromolecular Design, 2014, University of New South Wales
URL: http://handle.unsw.edu.au/1959.4/54075
;
https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12852/SOURCE02?view=true
► The biomimetically inspired polydopamine coating is a facile surface coating process suitable for a range of substrates. These coatings are robust and provide a wide…
(more)
▼ The biomimetically inspired
polydopamine coating is a facile surface coating process suitable for a range of substrates. These coatings are robust and provide a wide array of accessible functional groups for further surface modification. This dissertation describes the use of
polydopamine coatings on magnetoelastic alloy substrates and silicon dioxide nanoparticles. The magnetoelastic alloys can function as biochemical detection devices if suitably coated with a ‘chemically responsive layer’ to provide an attractive surface for analytes. The silicon dioxide nanoparticles can be further processed to create specially coated hollow particles for ‘smart’ delivery of therapeutic agents. The successful creation of the
polydopamine coatings was confirmed with ATR-FTIR, contact angle measurements and thermogravimetric analysis for the particles.Once the
polydopamine coatings were created they were further modified to create glycopolymer coated surfaces for protein binding. These glycopolymer coatings were created by attaching polymer brushes to the
polydopamine coated substrates. Both traditional ‘grafting to’ and ‘grafting from’ techniques were employed to create polymer brushes of varying grafting densities. Reversible addition-fragmentation chain transfer (RAFT) controlled radical polymerization techniques were used to grow polymer brushes with narrow dispersities and specific molecular weights. While ‘grafting from’ techniques produce a higher grafting density, they typically involve two steps – initiator deposition followed by polymerization. A one-pot single-step method of simultaneously growing a polymer brush and attaching it to a surface was successfully created utilizing a carbonyl azide-terminated RAFT agent for isocyanate coupling. The polymer brush coatings offer the advantages of increased effective surface areas over bulk polymer coatings per unit substrate surface area. Poly(pentafluorostyrene) polymer brushes were created and then simple ‘thiol-click’ reactions with 1-thio-beta-glucose were performed to convert the poly(pentafluorostyrene) polymer brushes to glycopolymers. Thermogravimetric analysis, ATR-FTIR and contact angle measurements confirmed the successful glucosylation of the polymer brushes. Preliminary protein binding results confirmed via confocal microscopy and fluorescence lifetime imaging microscopy (FLIM) showed that protein binding successfully occurred on the glycopolymer coated materials. This work represents the unique combination of
polydopamine coatings with glycopolymer brushes via facile synthesis routes to create materials with potential in biochemical detection and as ‘smart’ drug delivery devices.
Advisors/Committee Members: Granville, Anthony, Faculty of Engineering, UNSW.
Subjects/Keywords: RAFT; polymer; polydopamine; polymer brush; glycopolymer; biosensing; drug delivery; glycopolymer brush; surface science; surface initiated polymerization
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APA (6th Edition):
Le-Masurier, S. (2014). Polydopamine coated substrates as scaffolds for glycopolymer brushes attached via one-pot 'grafting from' synthesis and para-fluoro 'click chemistry' for biomedical applications. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/54075 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12852/SOURCE02?view=true
Chicago Manual of Style (16th Edition):
Le-Masurier, Solomon. “Polydopamine coated substrates as scaffolds for glycopolymer brushes attached via one-pot 'grafting from' synthesis and para-fluoro 'click chemistry' for biomedical applications.” 2014. Doctoral Dissertation, University of New South Wales. Accessed October 14, 2019.
http://handle.unsw.edu.au/1959.4/54075 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12852/SOURCE02?view=true.
MLA Handbook (7th Edition):
Le-Masurier, Solomon. “Polydopamine coated substrates as scaffolds for glycopolymer brushes attached via one-pot 'grafting from' synthesis and para-fluoro 'click chemistry' for biomedical applications.” 2014. Web. 14 Oct 2019.
Vancouver:
Le-Masurier S. Polydopamine coated substrates as scaffolds for glycopolymer brushes attached via one-pot 'grafting from' synthesis and para-fluoro 'click chemistry' for biomedical applications. [Internet] [Doctoral dissertation]. University of New South Wales; 2014. [cited 2019 Oct 14].
Available from: http://handle.unsw.edu.au/1959.4/54075 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12852/SOURCE02?view=true.
Council of Science Editors:
Le-Masurier S. Polydopamine coated substrates as scaffolds for glycopolymer brushes attached via one-pot 'grafting from' synthesis and para-fluoro 'click chemistry' for biomedical applications. [Doctoral Dissertation]. University of New South Wales; 2014. Available from: http://handle.unsw.edu.au/1959.4/54075 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12852/SOURCE02?view=true
25.
SONG LINA.
ANTI-BIOFOULING PVDF MEMBRANES IMMOBILIZEED WITH TiO2 NANOPARTICLES VIA POLYDOPAMINE.
Degree: 2015, National University of Singapore
URL: http://scholarbank.nus.edu.sg/handle/10635/121990
Subjects/Keywords: PVDF; membrane fouling; biofouling; nanoparticle; titanium dioxide; polydopamine
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APA (6th Edition):
LINA, S. (2015). ANTI-BIOFOULING PVDF MEMBRANES IMMOBILIZEED WITH TiO2 NANOPARTICLES VIA POLYDOPAMINE. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/121990
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
LINA, SONG. “ANTI-BIOFOULING PVDF MEMBRANES IMMOBILIZEED WITH TiO2 NANOPARTICLES VIA POLYDOPAMINE.” 2015. Thesis, National University of Singapore. Accessed October 14, 2019.
http://scholarbank.nus.edu.sg/handle/10635/121990.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
LINA, SONG. “ANTI-BIOFOULING PVDF MEMBRANES IMMOBILIZEED WITH TiO2 NANOPARTICLES VIA POLYDOPAMINE.” 2015. Web. 14 Oct 2019.
Vancouver:
LINA S. ANTI-BIOFOULING PVDF MEMBRANES IMMOBILIZEED WITH TiO2 NANOPARTICLES VIA POLYDOPAMINE. [Internet] [Thesis]. National University of Singapore; 2015. [cited 2019 Oct 14].
Available from: http://scholarbank.nus.edu.sg/handle/10635/121990.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
LINA S. ANTI-BIOFOULING PVDF MEMBRANES IMMOBILIZEED WITH TiO2 NANOPARTICLES VIA POLYDOPAMINE. [Thesis]. National University of Singapore; 2015. Available from: http://scholarbank.nus.edu.sg/handle/10635/121990
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Texas – Austin
26.
-5734-0418.
Fire safety in sustainable buildings : status, options, alternatives.
Degree: PhD, Mechanical Engineering, 2017, University of Texas – Austin
URL: http://hdl.handle.net/2152/47453
► Sustainable design is a holistic goal of efficiency and optimization to reduce building energy consumption and environmental impact while improving occupant health and safety. Sustainable…
(more)
▼ Sustainable design is a holistic goal of efficiency and optimization to reduce building energy consumption and environmental impact while improving occupant health and safety. Sustainable building construction is one of the fastest growing industries in the United States. Changes in materials, products, designs, and methodologies are occurring to accommodate this green progression. While these changes have energy and environmental benefits, questions have been raised about the impacts on fire safety. As sustainability is rapidly adopted in the building construction industry, so too must our understanding of fire safety implications. It is possible that a single fire event can negate several, if not all, elements of green design. Intermingling green design and fire safety such that they reinforce rather than undermine each other would produce a net benefit to both humans and the environment. Without this consideration, green design could unintentionally increase fire risk and damage. To begin addressing some of these concerns, a three-pronged approach was taken in this research. First, a detailed qualitative examination of the relationship between fire safety and sustainability in buildings was conducted, including a discussion on the status of the fire and sustainability communities and recommendations on areas for development and implementation to promote fire safe sustainable designs. This first analysis concludes that exchange between the sustainability and fire safety communities is inadequate. The fire safety community is focused on quantifying and tracking such implications with a concern for firefighter security and training, while the sustainability community is focused on meeting the minimum building code requirements for fire protection. Second, a quantitative analysis on thermal insulation, an essential building material, was performed to demonstrate the current options available to designers and regulators and, more generally, how to integrate both fire safety and sustainability in material selection. A pointed result of this work is that rockwool, an insulation popular in Europe but rarely used in the United States, consistently ranked as a top performer. In the third component of this work, an investigation into the viability of two alternative, reportedly environmentally benign flame retardants (FRs) was conducted for use on flexible polyurethane foam (PU), a prevalent material in interior furnishings. Several previously unknown characteristics of these unique FRs were discovered through this work, including dissimilarities to a conventional halogenated FR treatment. In summary, this research elucidates the current status of the nexus of fire safety and sustainability, offers an immediate method of selecting preferable material options, and validates sustainable FR alternatives.
Advisors/Committee Members: Ezekoye, Ofodike A. (advisor), Webber, Michael E., 1971- (advisor), Ellison, Christopher J. (committee member), Ellzey, Janet L. (committee member).
Subjects/Keywords: Fire safety; Sustainability; Insulation; Green building; Optimization; Flame retardant; Polydopamine; Flexible polyurethane foam; Thermal degradation; Kinetic parameters
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APA (6th Edition):
-5734-0418. (2017). Fire safety in sustainable buildings : status, options, alternatives. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/47453
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Chicago Manual of Style (16th Edition):
-5734-0418. “Fire safety in sustainable buildings : status, options, alternatives.” 2017. Doctoral Dissertation, University of Texas – Austin. Accessed October 14, 2019.
http://hdl.handle.net/2152/47453.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
MLA Handbook (7th Edition):
-5734-0418. “Fire safety in sustainable buildings : status, options, alternatives.” 2017. Web. 14 Oct 2019.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Vancouver:
-5734-0418. Fire safety in sustainable buildings : status, options, alternatives. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2017. [cited 2019 Oct 14].
Available from: http://hdl.handle.net/2152/47453.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Council of Science Editors:
-5734-0418. Fire safety in sustainable buildings : status, options, alternatives. [Doctoral Dissertation]. University of Texas – Austin; 2017. Available from: http://hdl.handle.net/2152/47453
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
University of Texas – Austin
27.
Cho, Joon Hee.
Bioinspired catecholic polymers for functional materials design.
Degree: PhD, Chemical Engineering, 2015, University of Texas – Austin
URL: http://hdl.handle.net/2152/46734
► Melanins and Polydopamine (PDA) are bioinspired catecholic polymers that are well known for their intriguing chemical structure and physiological functions. Indeed, PDA has a suite…
(more)
▼ Melanins and
Polydopamine (PDA) are bioinspired catecholic polymers that are well known for their intriguing chemical structure and physiological functions. Indeed, PDA has a suite of properties that are uncommon to many known organic materials and over the last decade researchers have endeavored to exploit those properties in technologically relevant materials. Those efforts notwithstanding, PDAs’ chemical structures have yet to be revealed in their entirety and their useful properties yet to be fully explored. In addition, given the natural presence of melanins and dopamine in many animals (including humans), along with their versatile functional features, these materials can serve as non-toxic additives to common polymers and thereby enhance their properties. Or they could, on their own, serve as eco-friendly functional organic films to be used in a variety of useful applications. To this end, we suggest first the potential of melanins as thermal stabilizers for common polymers by evaluating the addition of melanin to several model polymers with well-known degradation pathways. Small loadings of natural and synthetic melanins significantly alter the radical-initiated chain scission behavior of conventional polymers. Such loadings cause a dramatic increase in its onset decomposition temperature, indicating potential benefits for high temperature processing or increasing their upper use temperature in demanding applications. Second, we suggest thin films of synthetic melanin and poly(allylamine hydrochloride) be deposited layer-by-layer from dilute aqueous solutions in ambient conditions. The multilayer films show superior UV-protection performance and substantially extend the useful life of a conductive polymer film under UV light, demonstrating the utility of melanin films in high-tech applications. Third, we establish a synthetic approach to prepare block copolymers of poly(methyl methacrylate) (PMMA) and PDA using a modified atom transfer radical polymerization (ATRP) technique. These copolymers display very good solubility in a range of organic solvents and the spin cast thin films of the copolymers show a sharp reduction (by up to 50%) in protein adsorption compared to those of neat PMMA. The enhanced solvent processability, thermal stability, and low protein adsorption characteristics of this copolymer make it an attractive choice for antifouling coatings on large surfaces. Fourth, we exploit PDA to achieve block copolymer (BCP) lithography on a variety of soft-material surfaces. This biomimetic film serves as a reactive platform for subsequently grafting a surface neutral layer to chemically guide the perpendicular orientation of BCP lamellae. BCP nanopatterning may now be achieved over a large area on cheap, rough, and commercially available roll-to-roll flexible polymer substrates having a wide range of surface energies, surfaces that are of interest to be adapted for patterning. Fifth, we develop an efficient, environmentally friendly, and water-based flame-retardant surface nanocoating for highly…
Advisors/Committee Members: Ellison, Christopher J. (advisor), Willson, Carlton Grant (committee member), Freeman, Benny D. (committee member), Li, Wei (committee member), Koo, Joseph H. (committee member).
Subjects/Keywords: Catechol; Melanin; Polydopamine; PDA; Polymers; Thermal stabilizers; Melanin films; Block copolymers; Copolymer lithography; Flame-retardant nanocoating
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APA ·
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Export
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Manager
APA (6th Edition):
Cho, J. H. (2015). Bioinspired catecholic polymers for functional materials design. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/46734
Chicago Manual of Style (16th Edition):
Cho, Joon Hee. “Bioinspired catecholic polymers for functional materials design.” 2015. Doctoral Dissertation, University of Texas – Austin. Accessed October 14, 2019.
http://hdl.handle.net/2152/46734.
MLA Handbook (7th Edition):
Cho, Joon Hee. “Bioinspired catecholic polymers for functional materials design.” 2015. Web. 14 Oct 2019.
Vancouver:
Cho JH. Bioinspired catecholic polymers for functional materials design. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2015. [cited 2019 Oct 14].
Available from: http://hdl.handle.net/2152/46734.
Council of Science Editors:
Cho JH. Bioinspired catecholic polymers for functional materials design. [Doctoral Dissertation]. University of Texas – Austin; 2015. Available from: http://hdl.handle.net/2152/46734
Université de Montréal
28.
Wang, Kaojin.
Design and characterization of thermally-induced shape memory polymers
.
Degree: 2018, Université de Montréal
URL: http://hdl.handle.net/1866/20758
Subjects/Keywords: Polymères à mémoire de forme;
Acide cholique;
Polyester co-cristallisables;
Polydopamine;
Shape memory polymers;
Cholic acid;
Co-crystallizable polyesters;
Polydopamine
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APA (6th Edition):
Wang, K. (2018). Design and characterization of thermally-induced shape memory polymers
. (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/20758
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wang, Kaojin. “Design and characterization of thermally-induced shape memory polymers
.” 2018. Thesis, Université de Montréal. Accessed October 14, 2019.
http://hdl.handle.net/1866/20758.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wang, Kaojin. “Design and characterization of thermally-induced shape memory polymers
.” 2018. Web. 14 Oct 2019.
Vancouver:
Wang K. Design and characterization of thermally-induced shape memory polymers
. [Internet] [Thesis]. Université de Montréal; 2018. [cited 2019 Oct 14].
Available from: http://hdl.handle.net/1866/20758.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wang K. Design and characterization of thermally-induced shape memory polymers
. [Thesis]. Université de Montréal; 2018. Available from: http://hdl.handle.net/1866/20758
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
29.
Leclaire, Marie-Eve.
Validation et conditionnement d'un test PAMPA amélioré pour l'évaluation de la perméabilité membranaire de médicaments
.
Degree: 2015, Université de Montréal
URL: http://hdl.handle.net/1866/11948
Subjects/Keywords: PAMPA;
Perméabilité;
Polydopamine;
Bicouche lipidique;
Permeability;
Lipid bilayer;
hplc-ms/ms
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Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Leclaire, M. (2015). Validation et conditionnement d'un test PAMPA amélioré pour l'évaluation de la perméabilité membranaire de médicaments
. (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/11948
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Leclaire, Marie-Eve. “Validation et conditionnement d'un test PAMPA amélioré pour l'évaluation de la perméabilité membranaire de médicaments
.” 2015. Thesis, Université de Montréal. Accessed October 14, 2019.
http://hdl.handle.net/1866/11948.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Leclaire, Marie-Eve. “Validation et conditionnement d'un test PAMPA amélioré pour l'évaluation de la perméabilité membranaire de médicaments
.” 2015. Web. 14 Oct 2019.
Vancouver:
Leclaire M. Validation et conditionnement d'un test PAMPA amélioré pour l'évaluation de la perméabilité membranaire de médicaments
. [Internet] [Thesis]. Université de Montréal; 2015. [cited 2019 Oct 14].
Available from: http://hdl.handle.net/1866/11948.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Leclaire M. Validation et conditionnement d'un test PAMPA amélioré pour l'évaluation de la perméabilité membranaire de médicaments
. [Thesis]. Université de Montréal; 2015. Available from: http://hdl.handle.net/1866/11948
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Illinois – Urbana-Champaign
30.
Kang, Sen.
Self-healing strategies for lithium-ion battery anodes.
Degree: PhD, Materials Science & Engr, 2015, University of Illinois – Urbana-Champaign
URL: http://hdl.handle.net/2142/78628
► Thermal-mechanical failure of microelectronic devices often involves in the loss of conductivity of the metal traces and vias, which shortens the lifetime and requires replacement…
(more)
▼ Thermal-mechanical failure of microelectronic devices often involves in the loss of conductivity of the metal traces and vias, which shortens the lifetime and requires replacement of the entire unit. High-capacity Si composite electrodes in lithium-ion batteries also suffer from the damage of electrical interfaces (particle/binder interfaces) during battery operation, leading to rapid capacity loss. In this dissertation, autonomous restoration of electrical conductivity upon damage is demonstrated in composite battery anodes and a simple electrical circuit via two different approaches.
The first approach for conductivity restoration relies on the release of microencapsulated conductive particles to the fracture plane to reconstruct the damaged conductive pathways. In the second approach, dynamic ionic bonds are incorporated at the interface of polymer binder and Si nanoparticles in a composite battery electrode.
Robust microcapsules are prepared with carbon black suspensions high in solids loading (up to 0.2 g/mL) for electrical conductivity restoration. Octadecyl groups are covalently functionalized on oxidized carbon black surfaces by two different synthetic routes. Functionalization significantly increases particle hydrophobicity, and improves dispersability and suspension stability in hydrophobic solvents such as o-dichlorobenzene (o-DCB), enabling encapsulation by in situ emulsion polymerization. Upon rupture, microcapsules containing functionalized carbon black (FCB) suspensions exhibit significant particle release relative to microcapsules filled with unfunctionalized carbon black. Two types of core thickeners, epoxy resin or poly 3-hexylthiophene (P3HT), are used to enhance particle release from microcapsules.
Microcapsules containing FCB suspensions enable ex-situ conductivity restoration of damaged Si electrodes and an electric circuit. Rupturing of the microcapsules on the line crack of Si electrodes lead to the release of conductive FCB particles to the crack region and eventually full recovery (100 % restoration efficiency) of electrode conductivity. Similarly, partial conductivity restoration is achieved for a damaged electric circuit upon FCB release from microcapsules.
A protective
polydopamine (PDA) coating is applied to the microcapsule surfaces to enhance the capsule stability in battery electrolytes and other harsh environments. The polymerization of dopamine monomers is initiated by the addition of an oxidant (i.e. ammonium persulfate) in an aqueous solution of neutral pH. The resulting PDA coating is a dense and uniform layer (ca. 50 nm thick). The PDA protective coating significantly increases the capsule stability at elevated temperature (180 °C) as well as in a variety of organic solvents and acidic/basic solutions that otherwise lead to deflation and loss of core content of uncoated microcapsules. Most importantly, the PDA coated microcapsules show significantly reduced core loss in battery electrolyte over 60 days as compared to uncoated microcapsules.
Intrinsic…
Advisors/Committee Members: Sottos, Nancy R. (advisor), Sottos, Nancy R. (Committee Chair), White, Scott R. (committee member), Braun, Paul V. (committee member), Kilian, Kristopher A. (committee member).
Subjects/Keywords: self-healing; conductivity restoration; microelectronics; Li-ion batteries; Si composite anodes; electrical interfaces; carbon black functionalization; microcapsules; polydopamine coating; capsule stability; dynamic bonding; ionic bonding
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Kang, S. (2015). Self-healing strategies for lithium-ion battery anodes. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/78628
Chicago Manual of Style (16th Edition):
Kang, Sen. “Self-healing strategies for lithium-ion battery anodes.” 2015. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed October 14, 2019.
http://hdl.handle.net/2142/78628.
MLA Handbook (7th Edition):
Kang, Sen. “Self-healing strategies for lithium-ion battery anodes.” 2015. Web. 14 Oct 2019.
Vancouver:
Kang S. Self-healing strategies for lithium-ion battery anodes. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2015. [cited 2019 Oct 14].
Available from: http://hdl.handle.net/2142/78628.
Council of Science Editors:
Kang S. Self-healing strategies for lithium-ion battery anodes. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2015. Available from: http://hdl.handle.net/2142/78628
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Open Access Theses and Dissertations
