subject:(Pol meros Teses )

1. Freire, Ernane Rodrigues. Estudo das vari?veis de s?ntese e o efeito nas propriedades eletroqu?micas da polianilina.

Degree: 2019, Universidade Federal do Amazonas

URL: https://tede.ufam.edu.br/handle/tede/7678

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Existe uma busca crescente por energia limpa e renov?vel, que deve ser acompanhada pelo desenvolvimento de dispositivos eficientes de armazenamento de energia. Um dispositivo de… (more)

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Existe uma busca crescente por energia limpa e renov?vel, que deve ser acompanhada pelo desenvolvimento de dispositivos eficientes de armazenamento de energia. Um dispositivo de grande interesse ? o capacitor eletroqu?mico, especificamente, os pseudocapacitores que utilizam uma variedade de materiais como PANI ou ?xidos met?licos como eletrodos. A PANI ? um pol?mero intrinsecamente condutor que pode ser sintetizada pela rota qu?mica ou eletroqu?mica. A primeira ? a mais adequada para se obter um pol?mero com alto peso molecular, o que ? primordial para a aplica??o sugerida. Nesse intuito, este trabalho apresenta os resultados de estudos das varia??es das concentra??es do agente dopante, agente oxidante e temperatura de s?ntese qu?mica da PANI para futuras aplica??es eletroqu?micas. Os materiais obtidos foram caracterizados por MEV, espectroscopia de UV-vis, FTIR, voltametria c?clica (-0,2 a 1,2 V), carga/descarga galvanost?tica e imped?ncia eletroqu?mica. As caracteriza??es estruturais e ?pticas comprovaram a obten??o do pol?mero no estado condutor para todas as condi??es de s?nteses. As an?lises morfol?gicas revelaram a diminui??o do tamanho de gr?nulos conforme o aumento da concentra??o de ?cido sulf?rico (agente dopante). Enquanto que a segunda vari?vel de s?ntese mostrou tamanhos menores de gr?nulos na concentra??o de 2,5 mol.L-1 de PSA (agente oxidante). J? a varia??o de temperatura apresentou gr?nulos na superf?cie de nofibras nas temperaturas de s?ntese de -5 e 0?C, em contrapartida, ocorreu a forma??o de estruturas na forma de placas em 5?C. Os estudos por voltametria c?clica mostraram diferentes respostas para cada condi??o de s?ntese, tendo potenciais dos estados redox da PANI de acordo com a literatura e aus?ncia de picos redox em outras condi??es, em sua maioria, observou-se processos at? a velocidade de varredura de 25 mV.s-1. A capacit?ncia calculada por voltametria atingiu os maiores valores em 224, 271, 328,2 F.g-1, respectivamente, 0,5 mol.L-1 de ?cido sulf?rico, 3,5 mol.L-1 de PSA e 0?C, a 10 mV.s-1. Os maiores valores de capacit?ncia calculadas por carga/descarga foram para as mesmas condi??es. E pela imped?ncia, todas as amostras mostraram a presen?a de semic?rculo com baixa resist?ncia a transporte de carga e bons efeitos capacitivos.

The growing search for clean and renewable energy should be accompanied by the development of efficient energy storage devices. A device of great interest is the electrochemical capacitor, specifically the pseudocapacitors that use a variety of materials such as PANI or metal oxides as electrodes. PANI is an intrinsically conductive polymer that can be synthesized by the chemical or electrochemical route. The first is the most suitable to obtain a PANI with high molecular weight, which is paramount for suggested application. In this regard, this study presents the results of studies of variations in the concentrations of the dopant agent, oxidant agent and chemical synthesis temperature of PANI for possible application in supercapacitors. The materials obtained…

Advisors/Committee Members: Pocrifka, Leandro Aparecido, http://lattes.cnpq.br/6236326108324745, Rios, Emerson da Costa, http://lattes.cnpq.br/8791195940411823, Frota, Consuelo Alves da.

Subjects/Keywords: Pol?meros condutores; Capacitadores; ENGENHARIAS: ENGENHARIA DE MATERIAIS E METAL?RGICA; S?ntese qu?mica; Polianilina; Propriedades eletroqu?micas

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Freire, E. R. (2019). Estudo das vari?veis de s?ntese e o efeito nas propriedades eletroqu?micas da polianilina. (Masters Thesis). Universidade Federal do Amazonas. Retrieved from https://tede.ufam.edu.br/handle/tede/7678

Chicago Manual of Style (16^th Edition):

Freire, Ernane Rodrigues. “Estudo das vari?veis de s?ntese e o efeito nas propriedades eletroqu?micas da polianilina.” 2019. Masters Thesis, Universidade Federal do Amazonas. Accessed February 27, 2021. https://tede.ufam.edu.br/handle/tede/7678.

MLA Handbook (7^th Edition):

Freire, Ernane Rodrigues. “Estudo das vari?veis de s?ntese e o efeito nas propriedades eletroqu?micas da polianilina.” 2019. Web. 27 Feb 2021.

Vancouver:

Freire ER. Estudo das vari?veis de s?ntese e o efeito nas propriedades eletroqu?micas da polianilina. [Internet] [Masters thesis]. Universidade Federal do Amazonas; 2019. [cited 2021 Feb 27]. Available from: https://tede.ufam.edu.br/handle/tede/7678.

Council of Science Editors:

Freire ER. Estudo das vari?veis de s?ntese e o efeito nas propriedades eletroqu?micas da polianilina. [Masters Thesis]. Universidade Federal do Amazonas; 2019. Available from: https://tede.ufam.edu.br/handle/tede/7678

2. Oliveira, Luana Barbosa de. Produ??o e caracteriza??o de comp?sito de matriz geopolim?rica com adi??o de res?duo industrial.

Degree: 2019, Universidade Federal do Amazonas

URL: https://tede.ufam.edu.br/handle/tede/7706

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Os processos industriais geram uma variedade significativa de res?duos, de dif?cil decomposi??o final. A proposta dessa pesquisa ? apresentar uma alternativa para a deposi??o final… (more)

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Os processos industriais geram uma variedade significativa de res?duos, de dif?cil decomposi??o final. A proposta dessa pesquisa ? apresentar uma alternativa para a deposi??o final desse res?duo, mais especificamente do poliestireno. Enquanto os pol?meros convencionais s?o formados por estruturas de carbono, geopol?meros s?o constitu?dos de estruturas de s?lica e alumina. Dentre as poss?veis aplica??es, eles podem ser empregados em pastas, argamassas e concretos, em substitui??o ao cimento Portland. Para a adi??o do res?duo industrial na matriz geopolim?rica foi feita sua caracteriza??o, bem como dos precursores do geopol?mero. A an?lise de espectroscopia de infravermelho com transformada de Fourier (FTIR) demonstra que o res?duo utilizado possui em sua composi??o qu?mica uma maior quantidade de di?xido de sil?cio e di?xido de alum?nio. Os resultados da an?lise de difra??o de raios-X (DRX), feitos na amostra de res?duo e na matriz geopolim?rica confirma a composi??o qu?mica fornecida pela ind?stria bem com o processo de geopolimeriza??o. A an?lise de termogravimetria (TG) e derivada de termogravimetria (DTG) demonstram que o res?duo possui uma perda muito pequena de ?gua antes da degrada??o total da amostra. O ensaio de resist?ncia a compress?o evidenciou uma melhora significativa na incorpora??o do res?duo ? matriz geopolim?rica atingindo aos 28 dias cerca de 29,13 MPa (5% res?duo mo?do) e 40,44 MPa (5% res?duo peneirado). O ensaio de flex?o demonstra que a adi??o do res?duo peneirado a matriz resultou em uma melhora na resist?ncia que atingiu 2,07 e uma deforma??o de 0,66mm, cerca de 7,73% maior em rela??o a matriz.

Industrial processes generate a significant variety of residues which is difficult to decompose. The main goal of this research is to present an alternative for the final destination of this materials, specifically polystyrene. While main polymers are based of carbon structures, geopolymers are based of silica and alumina structures. Among possible applications, they can be used in pastes, mortars and concretes, replacing Portland cement. For the addition of the industrial residue in the geopolymer matrix was made its characterization, as well as the precursors of the geopolymer. The Fourier Transform Infrared Spectroscopy (FTIR) analysis demonstrates that the residue used has in its chemical composition a higher amount of silicon dioxide and aluminum dioxide. The results of X-ray diffraction (XRD) analysis on the residue sample and the geopolymer matrix confirm the chemical composition provided by the industry, as well as the geopolymerization process. Thermogravimetry (TG) and thermogravimetry derived (DTG) analysis show that the residue has very little water loss prior to total sample degradation. The compressive strength test showed a significant improvement on the residue?s incorporation to the geopolymer matrix, reaching at 28 days about 29.13 MPa (5% ground residue) and 4.44 MPa (5% screened residue). The flexure test demonstrates that the addition of the sieved residue to the matrix resulted…

Advisors/Committee Members: Manzato, Lizandro, http://lattes.cnpq.br/0677617028146410, Melo Filho, Jo?o de Almeida, http://lattes.cnpq.br/9045456793790448, Pinheiro, Ivanei Ferreira, http://lattes.cnpq.br/4206908141937691.

Subjects/Keywords: Geopol?meros; Res?duos industriais; Pol?meros - Biodegrada??o; Comp?sitos geopolim?ricos; Poliestireno; ENGENHARIAS: ENGENHARIA CIVIL: CONSTRU??O CIVIL: MATERIAIS E COMPONENTES DE CONSTRU??O; Geopol?meros; Poliestireno; Res?duo industrial; Comp?sitos geopolim?ricos

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Oliveira, L. B. d. (2019). Produ??o e caracteriza??o de comp?sito de matriz geopolim?rica com adi??o de res?duo industrial. (Masters Thesis). Universidade Federal do Amazonas. Retrieved from https://tede.ufam.edu.br/handle/tede/7706

Chicago Manual of Style (16^th Edition):

Oliveira, Luana Barbosa de. “Produ??o e caracteriza??o de comp?sito de matriz geopolim?rica com adi??o de res?duo industrial.” 2019. Masters Thesis, Universidade Federal do Amazonas. Accessed February 27, 2021. https://tede.ufam.edu.br/handle/tede/7706.

MLA Handbook (7^th Edition):

Oliveira, Luana Barbosa de. “Produ??o e caracteriza??o de comp?sito de matriz geopolim?rica com adi??o de res?duo industrial.” 2019. Web. 27 Feb 2021.

Vancouver:

Oliveira LBd. Produ??o e caracteriza??o de comp?sito de matriz geopolim?rica com adi??o de res?duo industrial. [Internet] [Masters thesis]. Universidade Federal do Amazonas; 2019. [cited 2021 Feb 27]. Available from: https://tede.ufam.edu.br/handle/tede/7706.

Council of Science Editors:

Oliveira LBd. Produ??o e caracteriza??o de comp?sito de matriz geopolim?rica com adi??o de res?duo industrial. [Masters Thesis]. Universidade Federal do Amazonas; 2019. Available from: https://tede.ufam.edu.br/handle/tede/7706

3. Biondo, Matheus Moraes; http://lattes.cnpq.br/9529264326603601. Chemically synthesized poly(o-methoxyaniline): influence of counterions on the structural and electrical properties.

Degree: 2019, Universidade Federal do Amazonas

URL: https://tede.ufam.edu.br/handle/tede/7661

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Poli(o-metoxianilinas) (POMA) foram sintetizadas quimicamente usando diferentes ?cidos dopantes para obter os pol?meros POMA/HCl, POMA/HNO3, POMA/H2SO4 e POMA/H3PO4. A natureza e o tamanho dos contra-?ons… (more)

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Poli(o-metoxianilinas) (POMA) foram sintetizadas quimicamente usando diferentes ?cidos dopantes para obter os pol?meros POMA/HCl, POMA/HNO3, POMA/H2SO4 e POMA/H3PO4. A natureza e o tamanho dos contra-?ons influenciaram consideravelmente nas propriedades estruturais, morfol?gicas, t?rmicas e el?tricas dos pol?meros sintetizados. Os padr?es de difra??o de raios X (DRX) apresentaram deslocamentos de pico de acordo com o ?cido dopante, influenciando nos par?metros da rede especialmente ao longo da dire??o [010]. Os pol?meros POMA/HCl, POMA/HNO3 e POMA/H2SO4 apresentaram percentuais semelhantes de cristalinidade (em torno de 50 %), enquanto o pol?mero POMA/H3PO4 foi o menos cristalino (em torno de 40 %). A morfologia polim?rica foi dependente do ?cido dopante, e multimorfologias foram observadas nos pol?meros POMA/HCl, POMA/HNO3, POMA/H2SO4 e POMA/H3PO4. Consider?vel influ?ncia do contra-?on proveniente do ?cido dopante foi constatada nas propriedades el?tricas. A varia??o total obtida na condutividade DC foi de cinco ordens de magnitude. Os valores calculados foram 6,6 x 10-1 S/cm, 1,11 x 10-2 S/cm, 3,64 x 10-3 S/cm e 5,2 x 10-4 S/cm para POMA/HCl, POMA/HNO3, POMA/H2SO4 e POMA/H3PO4, respectivamente. O uso de HCl como dopante potencializou a condutividade el?trica do material polim?rico.

Poly(o-methoxyanilines) (POMA) were chemically synthesized using different dopant acids to obtain the polymers POMA/HCl, POMA/HNO3, POMA/H2SO4 and POMA/H3PO4. The nature and size of the counterions influenced considerably on the structural, morphological, thermal and electrical properties of the as-synthesized polymers. X-ray Diffraction (XRD) patterns presented slightly peak displacements according to the dopant acid, influencing the lattice parameters specially along [010]. The polymers POMA/HCl, POMA/HNO3 and POMA/H2SO4 presented similar percentage of crystallinity (around 50 %), while the polymer POMA/H3PO4 was the less crystalline (around 40 %). Polymer morphology was dependent on the dopant acid, besides multimorphologies were observed in the polymers POMA/HCl, POMA/HNO3 and POMA/H3PO4. A great counterion influence from the doping acid was found in the electrical properties. The total variation obtained in DC conductivity was five orders of magnitude. The calculated values were 6.6 x 10-1 S/cm, 1.11 x 10-2 S/cm, 3.64 x 10-3 S/cm and 5.2 x 10-4 S/cm for POMA/HCl, POMA/HNO3, POMA/H2SO4 and POMA/H3PO4, respectively. The use of HCl as dopant potentiated the DC conductivity of the polymeric material.c

Advisors/Committee Members: Sanches, Edgar Aparecido, http://lattes.cnpq.br/9217911214522756, Aguilera Dom?nguez, Lianet, http://lattes.cnpq.br/9259625561946047, Paula, Marcos Marques da Silva, http://lattes.cnpq.br/9465127865782783.

Subjects/Keywords: Poli(o-metoxianilina); Condutividade el?trica; Pol?meros; ENGENHARIAS: ENGENHARIA DE MATERIAIS E METAL?RGICA; Poli(o-metoxianilina); M?todo Le Bail; Condutividade el?trica; Transportadores de carga

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Biondo, M. M. h. c. b. (2019). Chemically synthesized poly(o-methoxyaniline): influence of counterions on the structural and electrical properties. (Masters Thesis). Universidade Federal do Amazonas. Retrieved from https://tede.ufam.edu.br/handle/tede/7661

Chicago Manual of Style (16^th Edition):

Biondo, Matheus Moraes; http://lattes cnpq br/9529264326603601. “Chemically synthesized poly(o-methoxyaniline): influence of counterions on the structural and electrical properties.” 2019. Masters Thesis, Universidade Federal do Amazonas. Accessed February 27, 2021. https://tede.ufam.edu.br/handle/tede/7661.

MLA Handbook (7^th Edition):

Biondo, Matheus Moraes; http://lattes cnpq br/9529264326603601. “Chemically synthesized poly(o-methoxyaniline): influence of counterions on the structural and electrical properties.” 2019. Web. 27 Feb 2021.

Vancouver:

Biondo MMhcb. Chemically synthesized poly(o-methoxyaniline): influence of counterions on the structural and electrical properties. [Internet] [Masters thesis]. Universidade Federal do Amazonas; 2019. [cited 2021 Feb 27]. Available from: https://tede.ufam.edu.br/handle/tede/7661.

Council of Science Editors:

Biondo MMhcb. Chemically synthesized poly(o-methoxyaniline): influence of counterions on the structural and electrical properties. [Masters Thesis]. Universidade Federal do Amazonas; 2019. Available from: https://tede.ufam.edu.br/handle/tede/7661

Universidade de Lisboa

4. Barros, José Manuel Macedo Cota. Synchronization phenomena with nonlinear oscillators.

Degree: 2013, Universidade de Lisboa

URL: http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ul.pt:10451/10300

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Tese de mestrado em Física, apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2013

A sincronização é um fenómeno sobre organização, ou estados… (more)

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Tese de mestrado em Física, apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2013

A sincronização é um fenómeno sobre organização, ou estados organizados, e que pode ser observado na natureza. Neste trabalho foi imposto o objetivo de estudar e observar este fenómeno, usando ferramentas matemáticas e laboratoriais. Como base para o trabalho foi escolhido o caso de dois osciladores acoplados. Este é o estado fundamental da dinâmica coletiva de sistemas acoplados, ou seja, mesmo no estudo de vários osciladores acoplados (n > 2), a dinâmica fundamental é a de primeiros vizinhos. Sabendo as condições necessárias, nomeadamente, a necessidade de um oscilador autossustentado, seguiu-se o modelo do oscilador de van der Pol, que é representado por uma equação diferencial não linear e homogénea. A dinâmica de osciladores acoplados é um estudo atualmente bastante desenvolvido, o que o torna muito diversificado. Sabendo que um modelo matemático - um oscilador autossustentado - pode modelar o batimento cardíaco, as reações químicas, os pêndulos, e muitos outros casos, o problema inicial é tentar compreender numa expressão geral o acoplamento. Sem levar o estudo da estabilidade à exaustão, referimos que para sistemas da forma do oscilador de van der Pol, com um acoplamento arbitrário que dependa das posições e velocidades, o sistema apresenta regimes estáveis. Desta forma, achámos interessante estudar, em particular, um acoplamento de primeiros vizinhos, através de uma constante denominada de constante de acoplamento. No capítulo 1 é apresentada uma introdução ao tópico de sincronização, ao oscilador de van der Pol, e à função de acoplamento. São utilizadas noções de topologia, de teoria de grafos, e dos sistemas dinâmicos na construção de uma base sólida para escrever as equações acopladas, justificando os termos de acoplamento. Neste mesmo capítulo são introduzidas outras noções importantes na compreensão do fenómeno e dos seus resultados, tal como fase, detuning, matriz de Kirchhoff e matriz de output. Como queremos saber resultados para as equações, foi igualmente necessária uma pesquisa de métodos perturbativos para resolução de equações diferenciais não lineares acopladas, a qual resultou no método desenvolvido por Nikolay Krylov e Nikolay Bogoliubov. Este é um método que mostra que, para certas condições, podemos considerar a fase e a amplitude constantes durante um período da oscilação, e como tal, podemos tomar a média temporal. Este método é desenvolvido no final do capítulo 1. É também justificada a necessidade de, para dois osciladores, encontrarmos uma equação da evolução da sua diferença de fase, o que nos dará uma medida para determinar se ocorreu, ou não, sincronização, visto que o sucesso implica que a diferença de fase, após transiente, deverá ser constante. Para o caso de mais osciladores, trataremos de estudar a diferença de fase entre cada 2 vizinhos. No capítulo 2 tratamos a sincronização em sua plenitude, voltando a apresentar as equações e resolvendo-as analiticamente e usando o…

Advisors/Committee Members: Nunes, Ana, 1958-.

Subjects/Keywords: Sincronização; Van der Pol; Equações diferenciais; Não linear; Acoplamento; Circuitos; Teses de mestrado - 2013

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Barros, J. M. M. C. (2013). Synchronization phenomena with nonlinear oscillators. (Thesis). Universidade de Lisboa. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ul.pt:10451/10300

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Barros, José Manuel Macedo Cota. “Synchronization phenomena with nonlinear oscillators.” 2013. Thesis, Universidade de Lisboa. Accessed February 27, 2021. http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ul.pt:10451/10300.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Barros, José Manuel Macedo Cota. “Synchronization phenomena with nonlinear oscillators.” 2013. Web. 27 Feb 2021.

Vancouver:

Barros JMMC. Synchronization phenomena with nonlinear oscillators. [Internet] [Thesis]. Universidade de Lisboa; 2013. [cited 2021 Feb 27]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ul.pt:10451/10300.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Barros JMMC. Synchronization phenomena with nonlinear oscillators. [Thesis]. Universidade de Lisboa; 2013. Available from: http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ul.pt:10451/10300

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hawaii – Manoa

5. DeBurger, Steven Michael. Pol Pot's total revolution : an inquiry of Democratic Kampuchea as a political religion.

Degree: 2016, University of Hawaii – Manoa

URL: http://hdl.handle.net/10125/100950

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Ph.D. University of Hawaii at Manoa 2012.

Employing Eric Voegelin's concept of 'political religions,' this dissertation constructs a narrative based on published memoirs and autobiographical… (more)

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Ph.D. University of Hawaii at Manoa 2012.

Employing Eric Voegelin's concept of 'political religions,' this dissertation constructs a narrative based on published memoirs and autobiographical reflections, as well as philosophical and historical texts, in a quest for an alternate understanding of the violence produced by Pol Pot's Communist Party of Kampuchea (CPK) during the political existence of Democratic Kampuchea from 1975-1979. Its goal is a discussion of the veiled aspects of the regime scholars may have only glossed over, those aspects mainly being politico-religious, spiritual, metaphysical, and aesthetic. Depicting certain vignettes, this work merely pieces together the hybrid assemblages that make up the Cambodian revolutionary aporia, or unresolved paradox. It tells the story of the physical and socio-spiritual destruction of the previous faith – Khmer Buddhism. This despiritualization creates a vacuum into which the CPK leadership, or Angkar, reconfigures itself as the new 'god'. It examines the spiritual, mystical, and aesthetic disintegration of the society and Angkar's implementation of itself as the substitutive source of transcendence, truth, beauty, and knowledge. The dissertation then veers off to consider, not only the mechanisms of the regime itself but the individual within the regime, the perpetrators of the violence, and more specifically the pnuemopathology, or spiritual sickness, of individuals that operated within the government's secret Phnom Penh prison and extermination facility Tuol Sleng. The ideologies and primacy of the regime are also studied, enabling for the construction of an alternate, or secondary reality, to exist within Tuol Sleng – a secondary reality where the acts of torture and murder become banal tasks for the maintenance of the government. It also goes on to describe the forging of the aesthetic state pursued by Angkar and its similarities to other regimes of terror. It also explains how Angkar shared revolutionary teleology with Mao Tse-tung thought, and more specifically how the peasant was used as an instrument of revolution. Finally, the role of ethnic-nationalism and the anti-Vietnamese sentiment is touched on, and how this ultimately led to the demise of the Khmer Rouge totalitarian political experiment.

Subjects/Keywords: Pol Pot

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

DeBurger, S. M. (2016). Pol Pot's total revolution : an inquiry of Democratic Kampuchea as a political religion. (Thesis). University of Hawaii – Manoa. Retrieved from http://hdl.handle.net/10125/100950

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

DeBurger, Steven Michael. “Pol Pot's total revolution : an inquiry of Democratic Kampuchea as a political religion.” 2016. Thesis, University of Hawaii – Manoa. Accessed February 27, 2021. http://hdl.handle.net/10125/100950.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

DeBurger, Steven Michael. “Pol Pot's total revolution : an inquiry of Democratic Kampuchea as a political religion.” 2016. Web. 27 Feb 2021.

Vancouver:

DeBurger SM. Pol Pot's total revolution : an inquiry of Democratic Kampuchea as a political religion. [Internet] [Thesis]. University of Hawaii – Manoa; 2016. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10125/100950.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

DeBurger SM. Pol Pot's total revolution : an inquiry of Democratic Kampuchea as a political religion. [Thesis]. University of Hawaii – Manoa; 2016. Available from: http://hdl.handle.net/10125/100950

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Schaughency, Paul Michael. ANALYSIS AND MAPPING OF RNA POLYMERASE II TERMINATION FACTORS.

Degree: 2014, Johns Hopkins University

URL: http://jhir.library.jhu.edu/handle/1774.2/37134

► Termination of transcription is an important, but poorly understood, cellular process. RNA polymerase II (Pol II) terminates coding transcripts and non-coding transcripts (ncRNAs) through two… (more)

Subjects/Keywords: RNA Pol II; Transcription; Termination

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schaughency, P. M. (2014). ANALYSIS AND MAPPING OF RNA POLYMERASE II TERMINATION FACTORS. (Thesis). Johns Hopkins University. Retrieved from http://jhir.library.jhu.edu/handle/1774.2/37134

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schaughency, Paul Michael. “ANALYSIS AND MAPPING OF RNA POLYMERASE II TERMINATION FACTORS.” 2014. Thesis, Johns Hopkins University. Accessed February 27, 2021. http://jhir.library.jhu.edu/handle/1774.2/37134.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schaughency, Paul Michael. “ANALYSIS AND MAPPING OF RNA POLYMERASE II TERMINATION FACTORS.” 2014. Web. 27 Feb 2021.

Vancouver:

Schaughency PM. ANALYSIS AND MAPPING OF RNA POLYMERASE II TERMINATION FACTORS. [Internet] [Thesis]. Johns Hopkins University; 2014. [cited 2021 Feb 27]. Available from: http://jhir.library.jhu.edu/handle/1774.2/37134.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schaughency PM. ANALYSIS AND MAPPING OF RNA POLYMERASE II TERMINATION FACTORS. [Thesis]. Johns Hopkins University; 2014. Available from: http://jhir.library.jhu.edu/handle/1774.2/37134

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Southern California

7. Khanna, Akshat. Characterizing the physiological roles and regulatory mechanisms of Maf1.

Degree: PhD, Molecular Biology, 2015, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/563262/rec/1319

► Obesity has become markedly more prevalent over the past two decades among developed countries however, the molecular events that connect obesity, lipid deregulation and human… (more)

▼ Obesity has become markedly more prevalent over the past two decades among developed countries however, the molecular events that connect obesity, lipid deregulation and human diseases are still unclear. Mammalian Maf1 was initially identified as a repressor of RNA Polymerase III-transcribed genes and studies have focused on examining it’s role in repressing RNA pol III-dependent targets. Our work surprisingly revealed that Maf1 is also able to directly repress RNA pol II genes, although little is known regarding these specific gene targets. Furthermore, we have identified a novel and conserved function for Maf1 in the maintenance of intracellular lipid pools in C. elegans and human cell culture. These results are the first to define a specific physiologic role for Maf1 in a multicellular organism. Maf1 negatively regulates lipid accumulation, in part, by repressing the expression of lipid biosynthesis genes. We hypothesize that Maf1 is a central node in the maintenance of organismal lipid homeostasis. These studies define Maf1 as an important new player in lipid metabolism and will be critical towards our future understanding of the roles that Maf1 plays in human diseases such as diabetes, obesity, and cancer, which display prominent lipid dysregulation phenotypes. Understanding the regulation of Maf1 will help us understand how these phenotypes are being impacted by Maf1. The Maf1 protein from yeast to mammals has been shown to have three regions of high similarity, but it’s still unclear how these three regions might regulate the signals that Maf1 responds to or the way Maf1 might regulate reproduction and lipid metabolism. We have found that removing the C-box domain from both Maf1 and MAFR-1, results in a constitutively nuclear protein. Moreover, this MAFR-1 mutant seems to act as a gain of function mutant as it represses the RNA Pol III targets in C. elegans just as the mafr-1 O/E strain. This mutant also negatively impacts reproduction and the lipid phenotypes. This domain is highly conserved with the human Maf1 and we believe it contains important residues that have not been implicated in regulating either Maf1 function or localization or both. Advisors/Committee Members: Curran, Sean P. (Committee Chair), Laird-Offringa, Ite A. (Committee Member), Tower, John G. (Committee Member), Ehrenreich, Ian (Committee Member).

Subjects/Keywords: obesity; RNA pol III; transcription

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Khanna, A. (2015). Characterizing the physiological roles and regulatory mechanisms of Maf1. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/563262/rec/1319

Chicago Manual of Style (16^th Edition):

Khanna, Akshat. “Characterizing the physiological roles and regulatory mechanisms of Maf1.” 2015. Doctoral Dissertation, University of Southern California. Accessed February 27, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/563262/rec/1319.

MLA Handbook (7^th Edition):

Khanna, Akshat. “Characterizing the physiological roles and regulatory mechanisms of Maf1.” 2015. Web. 27 Feb 2021.

Vancouver:

Khanna A. Characterizing the physiological roles and regulatory mechanisms of Maf1. [Internet] [Doctoral dissertation]. University of Southern California; 2015. [cited 2021 Feb 27]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/563262/rec/1319.

Council of Science Editors:

Khanna A. Characterizing the physiological roles and regulatory mechanisms of Maf1. [Doctoral Dissertation]. University of Southern California; 2015. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/563262/rec/1319

8. Renata Costella Acauan. Educação ambiental como método de intervenção comunitária na gestão ambiental local: o projeto meros do Brasil.

Degree: 2009, Universidade do Vale do Itajaí

URL: http://www6.univali.br/tede/tde_busca/arquivo.php?codArquivo=652

► As tentativas de melhoria da qualidade ambiental têm se tornado cada vez mais presentes nas cidades litorâneas, onde concentram-se mais de 50 % da população… (more)

▼ As tentativas de melhoria da qualidade ambiental têm se tornado cada vez mais presentes nas cidades litorâneas, onde concentram-se mais de 50 % da população mundial. A gestão destes ambientes está intimamente relacionada, entre outros fatores, ao modo como as pessoas se relacionam com o lugar onde vivem. Neste sentido, ações de Educação Ambiental (EA) tornam-se cada vez mais necessárias em qualquer processo de Gestão Ambiental. Avaliar estas ações é tão importante quanto sua própria execução, e mesmo assim são escassos os trabalhos de avaliação na área. Neste contexto insere-se o Projeto Meros do Brasil, uma proposta de Conservação da Biodiversidade Costeira e Marinha a partir de uma espéciesímbolo, o Mero (Epinephelus itajara), Dentro de suas linhas de ação, o Projeto busca a mobilização da comunidade por meio de um Programa de EA, para promover a intervenção comunitária no processo de gestão ambiental local. São realizadas atividades a partir de oficinas, cursos e diagnósticos participativos, com escolas e comunidades. Buscou-se com este trabalho analisar os instrumentos de Educação Ambiental utilizados no Projeto Meros do Brasil, enquanto método para promover a intervenção comunitária no processo de Gestão Ambiental Local. Para tal foram entendidos e analisados todos os processos de estruturação e implementação do Projeto, utilizando a estratégia da avaliação, identificados os instrumentos de EA e sugeridos indicadores de eficiência, e ainda por fim buscou-se gerar subsídios para o desenvolvimento de técnicas para inserção da EA na Gestão. Os resultados alcançados demonstram o potencial das ações de EA como estratégia para alcançar a participação efetiva da comunidade em trabalhos de Gestão, onde foi possível observar estratégias bem sucedidas, como o envolvimento da comunidade a partir da escola, o uso de metodologias participativas e de instrumentos diferenciados, bem como aquelas que tiveram pouco alcance, como as tentativas de abordagem direta à comunidade. Desta forma pode-se sugerir ajustes na metodologia do Projeto, bem como subsídios para outros trabalhos na área Advisors/Committee Members: Marcus Polette, Joaquim Olinto Branco.

Subjects/Keywords: avaliação; educação para gestão ambiental; gestão ambiental local; Projeto Meros do Brasil; TURISMO; evaluation; education for environmental management; local environmental management, Meros do Brasil Project

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Acauan, R. C. (2009). Educação ambiental como método de intervenção comunitária na gestão ambiental local: o projeto meros do Brasil. (Thesis). Universidade do Vale do Itajaí. Retrieved from http://www6.univali.br/tede/tde_busca/arquivo.php?codArquivo=652

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Acauan, Renata Costella. “Educação ambiental como método de intervenção comunitária na gestão ambiental local: o projeto meros do Brasil.” 2009. Thesis, Universidade do Vale do Itajaí. Accessed February 27, 2021. http://www6.univali.br/tede/tde_busca/arquivo.php?codArquivo=652.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Acauan, Renata Costella. “Educação ambiental como método de intervenção comunitária na gestão ambiental local: o projeto meros do Brasil.” 2009. Web. 27 Feb 2021.

Vancouver:

Acauan RC. Educação ambiental como método de intervenção comunitária na gestão ambiental local: o projeto meros do Brasil. [Internet] [Thesis]. Universidade do Vale do Itajaí; 2009. [cited 2021 Feb 27]. Available from: http://www6.univali.br/tede/tde_busca/arquivo.php?codArquivo=652.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Acauan RC. Educação ambiental como método de intervenção comunitária na gestão ambiental local: o projeto meros do Brasil. [Thesis]. Universidade do Vale do Itajaí; 2009. Available from: http://www6.univali.br/tede/tde_busca/arquivo.php?codArquivo=652

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Northeastern University

9. Benson, Ryan W. Structure function analysis of Escherichia coli pol IV.

Degree: PhD, Department of Biology, 2013, Northeastern University

URL: http://hdl.handle.net/2047/d20003117

► Translesion synthesis (TLS) DNA polymerases are low fidelity DNA polymerases responsible for inserting a deoxynucleotide opposite to and extending from replication-blocking DNA lesions that have… (more)

▼ Translesion synthesis (TLS) DNA polymerases are low fidelity DNA polymerases responsible for inserting a deoxynucleotide opposite to and extending from replication-blocking DNA lesions that have evaded high fidelity DNA repair pathways. E. coli DinB (DNA Pol IV) is a TLS polymerase of great interest because of its conservation throughout all domains of life and its relatively high intracellular basal level when compared to other DNA polymerases. Alternative activities of DinB other than its TLS ability include: roles in recombination, transcription, and a DNA replication "checkpoint." Using a structure/function strategy, we sought to better understand these activities by utilizing dinB alleles with different catalytic activities, in combination with other mutated genes involved in DNA replication or repair. This approach has allowed us to identify residues of DinB important for its various cellular tasks. In this work we have identified the roles of three highly conserved catalytic residues in the fidelity of lesion bypass of diverse lesions.; We also addressed the underlying mechanisms governing interactions between different bacterial DNA polymerases upon DNA damage treatment, which is likely to activate either DNA polymerase exchange and/or DNA replication checkpoints. By using the dnaE915 allele, encoding a variant of the replicative DNA Pol III catalytic α-subunit (Pol IIIα), we detected a DNA damage treatment-dependent growth arrest at in vivo DinB intracellular concentrations much lower than those in previous studies. A variety of intragenic dinB mutations localized to a specific area of DinB that suppressed any observed growth defects were also identified. We infer that this DinB face is interacting directly or indirectly with DNA Pol IIIα.; Lastly, we discovered a novel TLS independent role of DinB in the tolerance of DNA damage treatment. However, this role does not simply involve protein-protein interactions but requires the catalytic activity of DinB. Therefore, survival is likely the result of the largely error free synthesis of undamaged DNA that is independent of recA mediated recombination, induction of the SOS DNA damage response, or base excision repair. The structure/function analysis undertaken in this work has allowed us to discern and explore several activities of DinB other than its part in canonical DNA damage tolerance through strict TLS. This information will allow greater understanding of the mechanisms regulating both the TLS activity and other alternative roles that these specialized DNA polymerases might be playing in cells experiencing DNA damage or environmental stress.

Subjects/Keywords: DinB; DNA Pol III; DNA Pol IV; E. coli; TLS; Biology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Benson, R. W. (2013). Structure function analysis of Escherichia coli pol IV. (Doctoral Dissertation). Northeastern University. Retrieved from http://hdl.handle.net/2047/d20003117

Chicago Manual of Style (16^th Edition):

Benson, Ryan W. “Structure function analysis of Escherichia coli pol IV.” 2013. Doctoral Dissertation, Northeastern University. Accessed February 27, 2021. http://hdl.handle.net/2047/d20003117.

MLA Handbook (7^th Edition):

Benson, Ryan W. “Structure function analysis of Escherichia coli pol IV.” 2013. Web. 27 Feb 2021.

Vancouver:

Benson RW. Structure function analysis of Escherichia coli pol IV. [Internet] [Doctoral dissertation]. Northeastern University; 2013. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2047/d20003117.

Council of Science Editors:

Benson RW. Structure function analysis of Escherichia coli pol IV. [Doctoral Dissertation]. Northeastern University; 2013. Available from: http://hdl.handle.net/2047/d20003117

Louisiana State University

10. Wang, Qing. Regulatory Impacts of Assembled Pol III Complexes on Neighboring Pol II Transcribed Genes in Saccharomyces cerevisiae.

Degree: PhD, 2015, Louisiana State University

URL: etd-10302015-120951 ; https://digitalcommons.lsu.edu/gradschool_dissertations/2826

► RNA polymerase III (Pol III) transcribes tRNAs as well as other small non-coding RNAs. tRNA genes contain internal promoter sequences (A- and B-boxes) which can… (more)

▼ RNA polymerase III (Pol III) transcribes tRNAs as well as other small non-coding RNAs. tRNA genes contain internal promoter sequences (A- and B-boxes) which can be specifically recognized and bound by TFIIIC. Binding of TFIIIC facilitates TFIIIB recruitment, which in turn targets Pol III to be recruited and initiate transcription. In addition to typical tRNA genes, there are other chromosomal regions, referred as extra-TFIIIC (ETC) sites, that are only bound by TFIIIC. Apart from transcription of genes, both complete and partially assembled Pol III complexes perform extra-transcriptional functions such as influencing nearby Pol II transcription, displacement of nearby nucleosomes, as well as chromatin boundary activities. By analyzing transcriptome data from high throughput RNA sequencing, we observed numerous alterations in intergenic transcription in close proximity to tDNAs and other Pol III complex binding sites after TFIIIC binding was globally compromised. Reduction of TFIIIC binding activity was achieved by using a yeast strain containing a mutation in the Reb1p binding site within the TFC6 promoter, which drastically reduces the level of the TFIIIC component Tfc6p. Analysis of loci adjacent to Pol III complex binding sites reveal both 5’- and 3’-extended transcripts, readthrough transcripts, and increased intergenic cryptic transcription. Many of the effects of 5’-UTR extension and de-repression appear to be due to the release of bidirectional activity of neighboring promoters. Translation of affected mRNAs is greatly altered because of the usage of upstream transcriptional start site (TSSs) at both TFC6 and TRM12 loci. The results presented here add another type of boundary activity to the known list of extra-transcriptional functions – the blocking activity of transcription from bidirectional promoters. Also, such activities might explain a function of the conserved ETC sites in yeast Saccharomyces cerevisiae. Analysis of the TFC6 locus suggests regulatory effects of assembled Pol III complexes at ETC6 site. Also, Reb1p is confirmed to be the transcriptional factor that binds and activates the TFC6 promoter and it binds several base pairs upstream of the ETC6 site. Analysis of these two divergently transcribed genes (ESC2 and TFC6) reveals that both have 5’-UTR extensions after Reb1p is depleted or the Reb1 consensus binding site is mutated, which is consistent with results from our transcriptome data. Similarly, altered TSS results in a significant decrease of the translational level of both TFC6 and ESC2. By assessing nucleosome content within the intergenic region ESC2-TFC6, we find that nucleosome positioning is slightly altered, which could explain the observed 5’-extended transcripts of both genes. Taken together, both of these studies demonstrate significant effects of assembled Pol III complexes and Reb1p binding on the transcription of neighboring Pol II promoters and on the translation of their mRNA products.

Subjects/Keywords: TFC6; Reb1; tRNA; TFIIIC complexes; Pol III complexes; Pol II

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, Q. (2015). Regulatory Impacts of Assembled Pol III Complexes on Neighboring Pol II Transcribed Genes in Saccharomyces cerevisiae. (Doctoral Dissertation). Louisiana State University. Retrieved from etd-10302015-120951 ; https://digitalcommons.lsu.edu/gradschool_dissertations/2826

Chicago Manual of Style (16^th Edition):

Wang, Qing. “Regulatory Impacts of Assembled Pol III Complexes on Neighboring Pol II Transcribed Genes in Saccharomyces cerevisiae.” 2015. Doctoral Dissertation, Louisiana State University. Accessed February 27, 2021. etd-10302015-120951 ; https://digitalcommons.lsu.edu/gradschool_dissertations/2826.

MLA Handbook (7^th Edition):

Wang, Qing. “Regulatory Impacts of Assembled Pol III Complexes on Neighboring Pol II Transcribed Genes in Saccharomyces cerevisiae.” 2015. Web. 27 Feb 2021.

Vancouver:

Wang Q. Regulatory Impacts of Assembled Pol III Complexes on Neighboring Pol II Transcribed Genes in Saccharomyces cerevisiae. [Internet] [Doctoral dissertation]. Louisiana State University; 2015. [cited 2021 Feb 27]. Available from: etd-10302015-120951 ; https://digitalcommons.lsu.edu/gradschool_dissertations/2826.

Council of Science Editors:

Wang Q. Regulatory Impacts of Assembled Pol III Complexes on Neighboring Pol II Transcribed Genes in Saccharomyces cerevisiae. [Doctoral Dissertation]. Louisiana State University; 2015. Available from: etd-10302015-120951 ; https://digitalcommons.lsu.edu/gradschool_dissertations/2826

Cornell University

11. Chachra, Ricky. Science In High Dimensions: Multiparameter Models And Big Data.

Degree: PhD, Theoretical and Applied Mechanics, 2014, Cornell University

URL: http://hdl.handle.net/1813/36155

► Complex multiparameter models such as in climate science, economics, systems biology, materials science, neural networks and machine learning have a large-dimensional space of undetermined parameters… (more)

Subjects/Keywords: stock markets; sloppy models; van der Pol

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APA (6^th Edition):

Chachra, R. (2014). Science In High Dimensions: Multiparameter Models And Big Data. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/36155

Chicago Manual of Style (16^th Edition):

Chachra, Ricky. “Science In High Dimensions: Multiparameter Models And Big Data.” 2014. Doctoral Dissertation, Cornell University. Accessed February 27, 2021. http://hdl.handle.net/1813/36155.

MLA Handbook (7^th Edition):

Chachra, Ricky. “Science In High Dimensions: Multiparameter Models And Big Data.” 2014. Web. 27 Feb 2021.

Vancouver:

Chachra R. Science In High Dimensions: Multiparameter Models And Big Data. [Internet] [Doctoral dissertation]. Cornell University; 2014. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/1813/36155.

Council of Science Editors:

Chachra R. Science In High Dimensions: Multiparameter Models And Big Data. [Doctoral Dissertation]. Cornell University; 2014. Available from: http://hdl.handle.net/1813/36155

Queens University

12. Liu, Tianshu. Novel High Power Density Topologies and Control for the Point-of-Load (POL) Application .

Degree: Electrical and Computer Engineering, 2016, Queens University

URL: http://hdl.handle.net/1974/14238

► High performance microprocessors are promoting the development of modern electronic devices such as smart phones and tablets. These microprocessors have stricter requirement on the power… (more)

Subjects/Keywords: Power Electronics ; POL Converter ; DC-DC Converter

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APA (6^th Edition):

Liu, T. (2016). Novel High Power Density Topologies and Control for the Point-of-Load (POL) Application . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/14238

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Liu, Tianshu. “Novel High Power Density Topologies and Control for the Point-of-Load (POL) Application .” 2016. Thesis, Queens University. Accessed February 27, 2021. http://hdl.handle.net/1974/14238.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Liu, Tianshu. “Novel High Power Density Topologies and Control for the Point-of-Load (POL) Application .” 2016. Web. 27 Feb 2021.

Vancouver:

Liu T. Novel High Power Density Topologies and Control for the Point-of-Load (POL) Application . [Internet] [Thesis]. Queens University; 2016. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/1974/14238.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Liu T. Novel High Power Density Topologies and Control for the Point-of-Load (POL) Application . [Thesis]. Queens University; 2016. Available from: http://hdl.handle.net/1974/14238

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Northeastern University

13. Antczak, Nicole M. Specificity of damage-bypass DNA polymerases E. coli DinB and human pol κ.

Degree: PhD, Department of Chemistry and Chemical Biology, 2017, Northeastern University

URL: http://hdl.handle.net/2047/D20260514

► DNA damage is a constant threat and can block replication. Y-family DNA polymerases can replicate damaged DNA through the process of translesion synthesis (TLS). Y-family… (more)

▼ DNA damage is a constant threat and can block replication. Y-family DNA polymerases can replicate damaged DNA through the process of translesion synthesis (TLS). Y-family DNA polymerases are conserved in all domains of life and bypass specific DNA damage in either an error-free or error-prone manner. This dissertation presents work to understand the damage specificity and nucleotide incorporation specificity of Y-family DNA polymerase orthologs E. coli DinB and human pol κ.; Using site-directed mutagenesis we have created alanine mutations in the active site loop 1, adjacent to the incoming nucleotide, of both DinB and pol κ. These mutations resulted in a range of activity and fidelity opposite undamaged DNA and the preferred lesion of both polymerases, N². The variants that retained activity similar to the wild-type proteins had decreased fidelity, especially opposite N²-furfuryl-dG while the variants with decreased activity did not show a decrease in fidelity.; Both E. coli DinB and human pol κ are able to bypass minor groove adducts on the N² position of deoxyguanine efficiently and correctly while adducts in the major groove, such as the N⁶ position of deoxyadenine are blocking lesions. However, another DinB ortholog, archaeal Dpo4 can bypass major groove adducts. The active site loop of these three proteins differs in length and in order to determine if the active site loops are important for damage specificity we created loop swap chimeras of the three proteins. We found that pol κ is tolerant to increases in length of its active site loop but DinB is not tolerant to increases or decreases in the length of its active site loop.; Y-family DNA polymerases have been implicated in antibiotic resistance as well as cancer and chemotherapy resistance. We found that two pol κ mutations found in cancer tumors have an increase in insertion and extension activity as well as decreases in fidelity opposite both minor groove and major groove adducts. It is believed that Y-family DNA polymerases could be targets to increase chemotherapeutic efficacy and decrease antibiotic resistance. Using a computational molecular modeling screen, a number of potential inhibitors of DinB were identified and we found that the compounds inhibit DinB at much lower concentrations than pol κ, and many do not inhibit pol κ even at high concentrations.; The work presented here reveals the important roles of the active site loop in DinB and pol in activity and fidelity. Point mutations in the DinB active site loop have a range of effects, whereas changing the length of the loop results in dramatic losses of activity. In contrast, human pol is far more tolerant to changes in its active site loop as well to potential inhibitors. This work suggests that DinB is overall more stringent in its lesion bypass activities than pol κ.

Subjects/Keywords: DNA polymerases; E. coli; pol κ

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Antczak, N. M. (2017). Specificity of damage-bypass DNA polymerases E. coli DinB and human pol κ. (Doctoral Dissertation). Northeastern University. Retrieved from http://hdl.handle.net/2047/D20260514

Chicago Manual of Style (16^th Edition):

Antczak, Nicole M. “Specificity of damage-bypass DNA polymerases E. coli DinB and human pol κ.” 2017. Doctoral Dissertation, Northeastern University. Accessed February 27, 2021. http://hdl.handle.net/2047/D20260514.

MLA Handbook (7^th Edition):

Antczak, Nicole M. “Specificity of damage-bypass DNA polymerases E. coli DinB and human pol κ.” 2017. Web. 27 Feb 2021.

Vancouver:

Antczak NM. Specificity of damage-bypass DNA polymerases E. coli DinB and human pol κ. [Internet] [Doctoral dissertation]. Northeastern University; 2017. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2047/D20260514.

Council of Science Editors:

Antczak NM. Specificity of damage-bypass DNA polymerases E. coli DinB and human pol κ. [Doctoral Dissertation]. Northeastern University; 2017. Available from: http://hdl.handle.net/2047/D20260514

University of Tennessee – Knoxville

14. Bouler, Douglas Wayne, III. GAN-BASED POINT-OF-LOAD CONVERTERS FOR DATA CENTER APPLICATIONS.

Degree: MS, Electrical Engineering, 2018, University of Tennessee – Knoxville

URL: https://trace.tennessee.edu/utk_gradthes/5341

► The growth of the information technology sector has increased demand for high-density, high-efficiency point-of-load (POL) converters. As industry continues to demand an increase in server… (more)

Subjects/Keywords: Gallium-Nitride; GaN; POL; power density

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APA (6^th Edition):

Bouler, Douglas Wayne, I. (2018). GAN-BASED POINT-OF-LOAD CONVERTERS FOR DATA CENTER APPLICATIONS. (Thesis). University of Tennessee – Knoxville. Retrieved from https://trace.tennessee.edu/utk_gradthes/5341

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bouler, Douglas Wayne, III. “GAN-BASED POINT-OF-LOAD CONVERTERS FOR DATA CENTER APPLICATIONS.” 2018. Thesis, University of Tennessee – Knoxville. Accessed February 27, 2021. https://trace.tennessee.edu/utk_gradthes/5341.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bouler, Douglas Wayne, III. “GAN-BASED POINT-OF-LOAD CONVERTERS FOR DATA CENTER APPLICATIONS.” 2018. Web. 27 Feb 2021.

Vancouver:

Bouler, Douglas Wayne I. GAN-BASED POINT-OF-LOAD CONVERTERS FOR DATA CENTER APPLICATIONS. [Internet] [Thesis]. University of Tennessee – Knoxville; 2018. [cited 2021 Feb 27]. Available from: https://trace.tennessee.edu/utk_gradthes/5341.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bouler, Douglas Wayne I. GAN-BASED POINT-OF-LOAD CONVERTERS FOR DATA CENTER APPLICATIONS. [Thesis]. University of Tennessee – Knoxville; 2018. Available from: https://trace.tennessee.edu/utk_gradthes/5341

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Παπανικολάου, Ξενοφών. Μελέτη της εξίσωσης van der Rol στο επίπεδο και υπό την παρουσία περιοδικών διαταραχών.

Degree: 2014, University of Patras

URL: http://hdl.handle.net/10889/7901

►

Η παρούσα διατριβή εκπονήθηκε ως μια διπλώματική εργασία υπό την επίβλεψη του καθηγητή Αναστάσιου Μπούντη (Τμήμα Μαθηματικό Πανεπιστήμιο Πατρών), κατά την διάρκεια του ακαδημαικού έτους… (more)

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Η παρούσα διατριβή εκπονήθηκε ως μια διπλώματική εργασία υπό την επίβλεψη του καθηγητή Αναστάσιου Μπούντη (Τμήμα Μαθηματικό Πανεπιστήμιο Πατρών), κατά την διάρκεια του ακαδημαικού έτους 2012-2013. Στόχος μας ήταν να μελετήσουμε τόσο θεωρητικά όσο και αριθμητικά μη τετριμένες λύσεις και να κατανοήσουμε, σε γενικές γραμμές, τη συμπεριφορά της μη γραμμικής διαφορικής εξίσωσης δεύτερης τάξης van der Pol. Στη μελέτη που ακολουθεί εξετάζονται δύο περιπτώσεις της εξίσωσης van der Pol: η αυτόνομη μορφή και η μή αυτόνομη με περιοδικό εξαναγκασμό. Η εξίσωση που μελετάμε είναι μη γραμμική, οπότε για την ανάλυσή της χρησιμοποιείται η θεωρία διαταραχών μη γραμμικών διαφορικών εξισώσεων. Η θεωρία αυτή χρησιμοποιείται για τη κατασκευή προσεγγιστικών λύσεων, οι οποίες στη συνέχεια συγκρίνονται με τα αντίστοιχα αποτελέσματα που παράγονται μέσω αριθμητικής ολοκλήρωσης. Σχολιάζονται οι ομοιότητες και οι διαφορές μεταξύ των μεθόδων, τα πλεονεκτήματα και οι αδυναμίες τους. Συζητούνται επίσης ορισμένες από τις πιο χαρακτηριστικές ιδιότητες των λύσεων τόσο στη αυτόνομη, όσο και τη μη αυτόνομη μορφή της εξίσωσης. Ειδικότερα στο Kεφάλαιο 2 επικεντρωνόμαστε στην αυτόνομη μορφή και παραθέτουμε βασικούς ορισμούς και θεωρήματα της θεωρίας μη γραμμικών Σ.Δ.Ε, για την ποιοτική μελέτη της εξίσωσης. Μελετάται το είδος και η ευστάθεια των σημείων ισορροπίας και αποδεικνύεται η ύπαρξη οριακού κύκλου μέσω της θεωρίας Poincare-Bendixson. Με χρήση των μεθόδων ασυμπτωτικής επέκτασης, Poincare-Lindstedt και πολλαπλών χρονικών κλιμάκων της θεωρίας διαταραχών, προσδιορίζονται διαφορετικές προσεγγίσεις του οριακού κύκλου της εξίσωσης για 0<ε<<1. Σε κάθε περίπτωση κατασκευάζονται συγκριτικά διαγράμματα, όπου περιγράφονται οι λύσεις που δίνουν η αριθμητική ολοκλήρωση και οι αναλυτικές προσεγγίσεις. Στο Kεφάλαιο 3 αναλύονται μη αυτόνομες μορφές της εξίσωσης και διακρίνονται δύο περιπτώσεις: Διέγερση συχνότητας κοντά σε αυτή του αυτόνομου συστήματος και διέγερση συχνότητας μακριά από αυτή του αυτόνομου συστήματος. Στην πρώτη περίπτωση υπολογίζονται προσεγγίσεις των περιοδικών λύσεων της εξίσωσης με τις μεθόδους Poincare-Lindstedt και πολλαπλών χρονικών κλιμάκων και παρουσιάζονται σε διαγράμματα οι περιοδικές και οι σχεδόν-περιοδικές λύσεις για ορισμένες τιμές των παραμέτρων. Στη δεύτερη περίπτωση υπολογίζονται προσεγγιστικές λύσεις με τη μέθοδο δύο χρονικών κλιμάκων και κατασκευάζονται συγκριτικά διαγράμματα με τη λύση που δίνει η αριθμητική ολοκλήρωση, για τιμές παραμέτρων που αντιστοιχούν σε περιοδικές και σχεδόν-περιοδικές καταστάσεις. Στο τέλος του κεφαλαίου δείχνεται η ύπαρξη χαοτικής συμπεριφοράς στο σύστημα μας. Το Παράρτημα Α περιλαμβάνει τα κυριότερα στοιχεία, ορισμούς και θεωρήματα, της θεωρίας μη γραμμικών Σ.Δ.Ε, τα οποία αναφέρονται και εφαρμόζονται στα Κεφάλαια 2 και 3. Τέλος περέχονται όλα τα προγράμματα σε Mathematica, με τα οποία κατασκευάστηκαν τα διαγράμματα της εργασίας και πραγματοποιήθηκε η αριθμητική ολοκλήρωση των εξισώσεων.

This thesis elaborated as diploma work under the supervision of…

Advisors/Committee Members: Μπούντης, Αναστάσιος, Papanikolaou, Xenofon, Weele, Jacobus Pieter van der, Παπαγεωργίου, Βασίλειος.

Subjects/Keywords: Θεωρία διαταραχών; Εξίσωση van der Pol; 515.355; Perturbations methods; Equation van der Pol

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Παπανικολάου, �. (2014). Μελέτη της εξίσωσης van der Rol στο επίπεδο και υπό την παρουσία περιοδικών διαταραχών. (Masters Thesis). University of Patras. Retrieved from http://hdl.handle.net/10889/7901

Chicago Manual of Style (16^th Edition):

Παπανικολάου, Ξενοφών. “Μελέτη της εξίσωσης van der Rol στο επίπεδο και υπό την παρουσία περιοδικών διαταραχών.” 2014. Masters Thesis, University of Patras. Accessed February 27, 2021. http://hdl.handle.net/10889/7901.

MLA Handbook (7^th Edition):

Παπανικολάου, Ξενοφών. “Μελέτη της εξίσωσης van der Rol στο επίπεδο και υπό την παρουσία περιοδικών διαταραχών.” 2014. Web. 27 Feb 2021.

Vancouver:

Παπανικολάου �. Μελέτη της εξίσωσης van der Rol στο επίπεδο και υπό την παρουσία περιοδικών διαταραχών. [Internet] [Masters thesis]. University of Patras; 2014. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10889/7901.

Council of Science Editors:

Παπανικολάου �. Μελέτη της εξίσωσης van der Rol στο επίπεδο και υπό την παρουσία περιοδικών διαταραχών. [Masters Thesis]. University of Patras; 2014. Available from: http://hdl.handle.net/10889/7901

Brno University of Technology

16. Kovařík, Jindřich. Záložní zdroj pro mobilní telefony: Backup power-pack for cell phones.

Degree: 2019, Brno University of Technology

URL: http://hdl.handle.net/11012/783

► This Bachelor`s thesis is focused on the issue of high energy intensity modern mobile phones. The aim is to create a backup power supply with… (more)

Subjects/Keywords: Li-Pol; spínané měniče; LED svítilna; Li-Pol; switching converters; LED Flashlight

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kovařík, J. (2019). Záložní zdroj pro mobilní telefony: Backup power-pack for cell phones. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/783

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kovařík, Jindřich. “Záložní zdroj pro mobilní telefony: Backup power-pack for cell phones.” 2019. Thesis, Brno University of Technology. Accessed February 27, 2021. http://hdl.handle.net/11012/783.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kovařík, Jindřich. “Záložní zdroj pro mobilní telefony: Backup power-pack for cell phones.” 2019. Web. 27 Feb 2021.

Vancouver:

Kovařík J. Záložní zdroj pro mobilní telefony: Backup power-pack for cell phones. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/11012/783.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kovařík J. Záložní zdroj pro mobilní telefony: Backup power-pack for cell phones. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/783

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Southern California

17. Erdem, Ayşen Lisa. The role of ATP in the regulation of Escherichia coli DNA polymerase V activity.

Degree: PhD, Molecular Biology, 2015, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/538236/rec/7200

► In Escherichia coli, DNA damage elicits the well regulated SOS response, which occurs in two phases. The first phase of SOS is dominated by accurate… (more)

▼ In Escherichia coli, DNA damage elicits the well regulated SOS response, which occurs in two phases. The first phase of SOS is dominated by accurate repair processes such as excision repair and recombinational DNA repair, while the second phase is characterized by a large increase in mutations caused by error-prone replication of damaged DNA templates. This phase of the SOS response is mediated by DNA polymerases that replicate past template lesions in a process called translesion synthesis (TLS). It is DNA polymerase V (UmuD′₂C), encoded by the LexA-regulated umuDC operon, that is responsible for most of the damage-induced chromosomal mutations. It is therefore not surprising that DNA polymerase V (pol V) expression and activity are tightly regulated so as to restrict the time and place the polymerase can perform DNA synthesis. In addition to transcriptional regulation by the LexA protein, pol V is post-transcriptionally regulated through proteolysis and by the RecA nucleoprotein filament (RecA*). UmuD2 undergoes RecA*-mediated autodigestion, resulting in the mutagenically active form UmuD2′ which forms a stable heterotrimeric complex with UmuC resulting in UmuD′₂C. We have previously shown that the final conversion of the UmuD′₂C complex to a highly active TLS enzyme requires the transfer of a RecA subunit from the 3′ end of the RecA* filament to form UmuD′₂C-RecA-ATP, which we refer to as pol V Mut. ATP is part of the active complex, with approximately one molecule of ATP per active enzyme, and until now ATP has played an enigmatic role in the activation process. This thesis establishes three features of the roles of ATP in pol V Mut activity; 1) bound ATP is required for DNA synthesis; 2) pol V Mut is a DNA-dependent ATPase; 3) ATP is required to bind primer/template (p/t) DNA and ATP hydrolysis triggers dissociation of pol V Mut from the DNA. Pol V Mut formed with an ATPase-deficient RecA E38K/K72R mutant hydrolyzes ATP rapidly, establishing the DNA-dependent ATPase as an intrinsic property of pol V Mut distinct from the ATP hydrolytic activity of RecA*. No similar ATPase activity or autoregulatory mechanism has previously been found for a DNA polymerase. The autoregulatory ATPase function provides a novel mechanistic explanation for the confinement of mutagenic DNA synthesis to short DNA segments surrounding lesions. The cellular risk of excessive and untargeted mutation is correspondingly reduced. ❧ The SOS response functions not only repair the DNA damage and restore the replication fork but also drive mutagenesis, thereby enhancing survival and contributing to bacterial evolution. Mobile genetic elements frequently found in virulent bacterial strains often carry SOS response genes homologous to pol V as well as antibiotic-resistance genes. DNA-damage induced by antibiotics sets off the SOS response including the expression of Umu-like polymerases in bacteria, which likely increases the genetic repertoire and disseminates pathogenic traits. This thesis also focuses on the characterization of a highly… Advisors/Committee Members: Goodman, Myron F. (Committee Chair), Michael, Matthew (Committee Member), Bradforth, Stephen E. (Committee Member).

Subjects/Keywords: pol V; pol V Mut; RecA; ATP; ATP hydrolysis; regulation; Rum; R391

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Erdem, A. L. (2015). The role of ATP in the regulation of Escherichia coli DNA polymerase V activity. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/538236/rec/7200

Chicago Manual of Style (16^th Edition):

Erdem, Ayşen Lisa. “The role of ATP in the regulation of Escherichia coli DNA polymerase V activity.” 2015. Doctoral Dissertation, University of Southern California. Accessed February 27, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/538236/rec/7200.

MLA Handbook (7^th Edition):

Erdem, Ayşen Lisa. “The role of ATP in the regulation of Escherichia coli DNA polymerase V activity.” 2015. Web. 27 Feb 2021.

Vancouver:

Erdem AL. The role of ATP in the regulation of Escherichia coli DNA polymerase V activity. [Internet] [Doctoral dissertation]. University of Southern California; 2015. [cited 2021 Feb 27]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/538236/rec/7200.

Council of Science Editors:

Erdem AL. The role of ATP in the regulation of Escherichia coli DNA polymerase V activity. [Doctoral Dissertation]. University of Southern California; 2015. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/538236/rec/7200

18. Yahia, Yousra. Caractérisation de mutants du domaine carboxy-terminal de l’ARN polymerase II dans des cellules mammifères : Characterization of RNA Polymerase II Carboxy-Terminal Domain mutants in mammalian cells.

Degree: Docteur es, Biologie Santé, 2017, Montpellier

URL: http://www.theses.fr/2017MONTT154

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La plus grosse sous-unité (Rpb1) de l'ARN polymérase II est caractérisée par une structure unique et flexible au niveau du domaine C-terminal (CTD) qui consiste… (more)

Subjects/Keywords: Transcription; RNA pol II CTD; Génomique; Transcription; RNA pol II CTD; Genomics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yahia, Y. (2017). Caractérisation de mutants du domaine carboxy-terminal de l’ARN polymerase II dans des cellules mammifères : Characterization of RNA Polymerase II Carboxy-Terminal Domain mutants in mammalian cells. (Doctoral Dissertation). Montpellier. Retrieved from http://www.theses.fr/2017MONTT154

Chicago Manual of Style (16^th Edition):

Yahia, Yousra. “Caractérisation de mutants du domaine carboxy-terminal de l’ARN polymerase II dans des cellules mammifères : Characterization of RNA Polymerase II Carboxy-Terminal Domain mutants in mammalian cells.” 2017. Doctoral Dissertation, Montpellier. Accessed February 27, 2021. http://www.theses.fr/2017MONTT154.

MLA Handbook (7^th Edition):

Yahia, Yousra. “Caractérisation de mutants du domaine carboxy-terminal de l’ARN polymerase II dans des cellules mammifères : Characterization of RNA Polymerase II Carboxy-Terminal Domain mutants in mammalian cells.” 2017. Web. 27 Feb 2021.

Vancouver:

Yahia Y. Caractérisation de mutants du domaine carboxy-terminal de l’ARN polymerase II dans des cellules mammifères : Characterization of RNA Polymerase II Carboxy-Terminal Domain mutants in mammalian cells. [Internet] [Doctoral dissertation]. Montpellier; 2017. [cited 2021 Feb 27]. Available from: http://www.theses.fr/2017MONTT154.

Council of Science Editors:

Yahia Y. Caractérisation de mutants du domaine carboxy-terminal de l’ARN polymerase II dans des cellules mammifères : Characterization of RNA Polymerase II Carboxy-Terminal Domain mutants in mammalian cells. [Doctoral Dissertation]. Montpellier; 2017. Available from: http://www.theses.fr/2017MONTT154

Ohio University

19. Chen, Yizhang. A Study of Mutagenesis by Translesion Synthesis DNA Polymerases Using A Novel High-throughput Mutation Assay System.

Degree: PhD, Biological Sciences (Arts and Sciences), 2018, Ohio University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1534928845629071

► DNA mutations can have devastating effects on cell growth, development, proliferation and survival through the regulation of gene expression and protein activity. Within various processes… (more)

▼ DNA mutations can have devastating effects on cell growth, development, proliferation and survival through the regulation of gene expression and protein activity. Within various processes that can create mutations, DNA damage is the major source of mutations. During the lifetime of a cell, DNA is constantly attacked by DNA damaging agents which can be either endogenously produced from cell metabolism or from surrounding environment. In addition, the intrinsic instability of DNA structure challenges genome integrity. While multiple DNA damage repair pathways can be activated to remove damage and restore DNA structure, a damage tolerance process, known as translesion synthesis (TLS), is essential for maintaining genome stability. TLS is a process in which a special group of DNA polymerases (TLS polymerases) synthesize DNA over a DNA lesion without repairing it. Since the DNA lesion cannot be the guide for the accurate base-pairing during DNA synthesis, TLS is often mutagenic and considered as the major mechanism for DNA damage-induced mutagenesis. In this study, a newly developed mutation assay system that takes the advantage of next-generation sequencing (NGS) technology, a high-throughput and efficient DNA sequencing technology, that was used to investigate the mutagenesis by TLS in vitro. This in vitro system successfully evaluated i) the fidelity of DNA synthesis by yeast TLS polymerases Pol Eta and Pol Zeta on intact templates; ii) base mis-incorporation generated by TLS over a specific DNA lesion (AP site) by multiple yeast DNA polymerases; iii) mis-incorporations generated through TLS on templates with random DNA lesions that were created by a DNA damaging agent (cisplatin). Yeast TLS polymerases mainly incorporated A and G opposite damaged sites. Mutations created by different TLS polymerases showed distinct signatures on the same template which could help in distinguishing their functions during TLS. Furthermore, while TLS introduced mutations at the lesion, the presence of DNA damage affected TLS fidelity around the lesion. Advisors/Committee Members: Sugiyama, Tomohiko (Advisor).

Subjects/Keywords: Biology; DNA Damage; Translesion Synthesis; Mutagenesis; Next-generation Sequencing; Pol Eta; Pol Zeta

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chen, Y. (2018). A Study of Mutagenesis by Translesion Synthesis DNA Polymerases Using A Novel High-throughput Mutation Assay System. (Doctoral Dissertation). Ohio University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1534928845629071

Chicago Manual of Style (16^th Edition):

Chen, Yizhang. “A Study of Mutagenesis by Translesion Synthesis DNA Polymerases Using A Novel High-throughput Mutation Assay System.” 2018. Doctoral Dissertation, Ohio University. Accessed February 27, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1534928845629071.

MLA Handbook (7^th Edition):

Chen, Yizhang. “A Study of Mutagenesis by Translesion Synthesis DNA Polymerases Using A Novel High-throughput Mutation Assay System.” 2018. Web. 27 Feb 2021.

Vancouver:

Chen Y. A Study of Mutagenesis by Translesion Synthesis DNA Polymerases Using A Novel High-throughput Mutation Assay System. [Internet] [Doctoral dissertation]. Ohio University; 2018. [cited 2021 Feb 27]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1534928845629071.

Council of Science Editors:

Chen Y. A Study of Mutagenesis by Translesion Synthesis DNA Polymerases Using A Novel High-throughput Mutation Assay System. [Doctoral Dissertation]. Ohio University; 2018. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1534928845629071

Penn State University

20. Portz, Bede. STRUCTURAL HETEROGENEITY IN THE RNA POLYMERASE II C-TERMINAL DOMAIN.

Degree: 2017, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/14228bzp105

► RNA polymerase II contains a repetitive and intrinsically disordered C-Terminal Domain (CTD) composed of heptad repeats of the consensus sequence YSPTSPS. The CTD can be… (more)

▼ RNA polymerase II contains a repetitive and intrinsically disordered C-Terminal Domain (CTD) composed of heptad repeats of the consensus sequence YSPTSPS. The CTD can be heavily phosphorylated and serves as a scaffold, interacting with factors involved in transcription initiation, elongation, termination, RNA processing and chromatin modification. Despite its role as a nexus of eukaryotic gene regulation, the structure of the CTD and the structural implications of CTD phosphorylation, are poorly understood. Additionally, there is an increasing awareness of the importance of intrinsically disordered proteins (IDPs) that function without adopting a stably folded structure. Here I present a biophysical and biochemical interrogation of the structure of the full-length CTD of D. melanogaster, which I conclude is a compact random coil. I find that the repetitive CTD is structurally heterogeneous as evidenced by a discontinuous pattern of cutting in limited proteolysis assays. Small Angle X-Ray scattering (SAXS) is a method ideally suited for the structural interrogation of large IDPs and can be employed to measure the size of a protein and to monitor structural changes in response to post-translational modification. Using SAXS I determined that phosphorylation by the kinase P-TEFb caused an increase in CTD radius and stiffness. Limited proteolysis of the phosphorylated CTD showed these gross structural changes are accompanied by increased protease accessibility and an alteration in relative protease accessibility across the length of the CTD. Additionally, we show that the human CTD is also structurally heterogeneous and able to substitute for the Drosophila melanogaster CTD in supporting the development of flies to adulthood. These finding implicate conserved structural organization, not a precise array of heptad motifs, as important to CTD function. The CTD is attached to the catalytic core of Pol II via a linker. I show that this linker is more compact than the CTD repeats and serves as an independent structural unit. The phosphorylated linker-CTD remains flexible relative to the phosphorylated CTD alone. Together, these results support a mechanism by which phosphorylation reduces the conformational entropy of the CTD, generating a more binding competent dock for CTD:protein interactions, with the linker region maintaining the ability of CTD bound factors to sample the 3-dimensional space which may be required for RNA processing and histone modification. The data described herein represent the most thorough structural characterization to date of the full length CTD on the global and local scales, examining both the overall size and local structural organization of the CTD. These studies establish the Drosophila CTD as an attractive model for the biophysical, biochemical and genetic interrogation of the structure and function of the CTD from a developmentally complex organism. Advisors/Committee Members: David Scott Gilmour, Dissertation Advisor/Co-Advisor, David Scott Gilmour, Committee Chair/Co-Chair, Katsuhiko Murakami, Committee Member, Benjamin Franklin Pugh, Committee Member, Scott A Showalter, Outside Member, Joseph C. Reese, Committee Member, Song Tan, Committee Member.

Subjects/Keywords: transcription; gene regulation; RNA Polymerase II; RNA Pol II; Pol II; Pol II CTD; CTD; C-terminal domain; small angle X-ray scattering; SAXS; intrinsically disordered protein; IDP

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Portz, B. (2017). STRUCTURAL HETEROGENEITY IN THE RNA POLYMERASE II C-TERMINAL DOMAIN. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/14228bzp105

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Portz, Bede. “STRUCTURAL HETEROGENEITY IN THE RNA POLYMERASE II C-TERMINAL DOMAIN.” 2017. Thesis, Penn State University. Accessed February 27, 2021. https://submit-etda.libraries.psu.edu/catalog/14228bzp105.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Portz, Bede. “STRUCTURAL HETEROGENEITY IN THE RNA POLYMERASE II C-TERMINAL DOMAIN.” 2017. Web. 27 Feb 2021.

Vancouver:

Portz B. STRUCTURAL HETEROGENEITY IN THE RNA POLYMERASE II C-TERMINAL DOMAIN. [Internet] [Thesis]. Penn State University; 2017. [cited 2021 Feb 27]. Available from: https://submit-etda.libraries.psu.edu/catalog/14228bzp105.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Portz B. STRUCTURAL HETEROGENEITY IN THE RNA POLYMERASE II C-TERMINAL DOMAIN. [Thesis]. Penn State University; 2017. Available from: https://submit-etda.libraries.psu.edu/catalog/14228bzp105

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. Cavalcante, Elizabeth Costa. Do p?lpito eclesial ao parlamentar: comunica??o, religi?o e pol?tica na C?mara Municipal de Manaus.

Degree: 2018, Universidade Federal do Amazonas

URL: https://tede.ufam.edu.br/handle/tede/7535

►

Trata-se de um Estudo de Caso de abordagem qualitativa e explorat?ria desenvolvido na C?mara Municipal de Manaus (CMM). O objetivo principal ? compreender as rela??es… (more)

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Trata-se de um Estudo de Caso de abordagem qualitativa e explorat?ria desenvolvido na C?mara Municipal de Manaus (CMM). O objetivo principal ? compreender as rela??es que permeiam entre os campos da comunica??o, religi?o e pol?tica da Frente Parlamentar Evang?lica na CMM. E, para isso, buscou-se caracterizar a Frente Parlamentar Evang?lica, apresentar a rela??o do campo comunicacional, religioso e pol?tico e identificar os processos comunicacionais dessa Frente. A pesquisa realizou-se por meio de entrevista semiestruturada e analisaram-se mat?rias jornal?sticas publicadas nos jornais locais on-line, no per?odo de 2015-2016. Verificou-se que o processo de comunica??o estabelecido visa ? midiatiza??o pol?tica dos parlamentares evang?licos da suposta Frente Parlamentar Evang?lica que, ao subirem no p?lpito parlamentar, recolocam sua viv?ncia religiosa na forma de leis. S?o parlamentares defensores de um conservadorismo religioso sustentado pela rigidez moral. As mat?rias jornal?sticas apresentam a atua??o dos parlamentares evang?licos na defesa dos valores da fam?lia, da moral crist?, desfigurando a plataforma dos movimentos homossexuais, dos grupos de direitos humanos e feministas. Esses pol?ticos evang?licos utilizam a estrutura de comunica??o da Casa Legislativa como forma de aproveitamento do espa?o p?blico para fins pol?tico-religiosos. As estrat?gias de disputa na CMM pelos vereadores evang?licos est?o inseridas no discurso pol?tico e nas a??es que promovem, em busca de notoriedade e reconhecimento, por interm?dio de abordagens religiosas propostas em Projeto de Lei, Projeto de Resolu??o, Decreto Legislativo, Mo??es, Indica??o, etc. Dessa forma, a manifesta??o religiosa n?o contraria o Estado laico brasileiro, mas se atrela ao espa?o pol?tico por meio do capital simb?lico (religioso), visando ao interesse de todo partido pol?tico: a manuten??o do poder no espa?o p?blico.

This is a case study of the qualitative and exploratory approach developed at Manaus City Council (CMM). The main objective is to understand the relations that permeate between the fields of communication, religion, and politics of the Evangelical Parliamentary Front in the CMM. And, for this, we sought to characterize the Evangelical Parliamentary Front, present the relationship of the communicational, religious and political field and identify the communicational processes of this Front. The research was conducted through semistructured interviews and analyzed journalistic articles published in local online newspapers, in the period 2015-2016. It was verified that the established communication process aims at the political mediatization of the evangelical parliamentarians of the supposed Evangelical Parliamentary Front who, when they rise in the parliamentary pulpit, put their religious experience back in the form of laws. They are parliamentarians who defend a religious conservatism sustained by moral rigidity. Journalistic articles present the role of evangelical parliamentarians in defending family values,…

Advisors/Committee Members: Abbud, Maria Em?lia de Oliveira Pereira, http://lattes.cnpq.br/8948660674436542, Monteiro, Gilson Vieira, http://lattes.cnpq.br/9075952334039287, Colferai, Sandro Alberto, http://lattes.cnpq.br/9217166268191537.

Subjects/Keywords: Partidos pol?ticos - Comunica??es - Manaus (AM); Partidos pol?ticos - Religi?o - Manaus (AM); CI?NCIAS HUMANAS; Ecossistemas Comunicacionais; Comunica??o; Campo Religi?o; Processos Comunicacionais; Campo Pol?tica

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cavalcante, E. C. (2018). Do p?lpito eclesial ao parlamentar: comunica??o, religi?o e pol?tica na C?mara Municipal de Manaus. (Masters Thesis). Universidade Federal do Amazonas. Retrieved from https://tede.ufam.edu.br/handle/tede/7535

Chicago Manual of Style (16^th Edition):

Cavalcante, Elizabeth Costa. “Do p?lpito eclesial ao parlamentar: comunica??o, religi?o e pol?tica na C?mara Municipal de Manaus.” 2018. Masters Thesis, Universidade Federal do Amazonas. Accessed February 27, 2021. https://tede.ufam.edu.br/handle/tede/7535.

MLA Handbook (7^th Edition):

Cavalcante, Elizabeth Costa. “Do p?lpito eclesial ao parlamentar: comunica??o, religi?o e pol?tica na C?mara Municipal de Manaus.” 2018. Web. 27 Feb 2021.

Vancouver:

Cavalcante EC. Do p?lpito eclesial ao parlamentar: comunica??o, religi?o e pol?tica na C?mara Municipal de Manaus. [Internet] [Masters thesis]. Universidade Federal do Amazonas; 2018. [cited 2021 Feb 27]. Available from: https://tede.ufam.edu.br/handle/tede/7535.

Council of Science Editors:

Cavalcante EC. Do p?lpito eclesial ao parlamentar: comunica??o, religi?o e pol?tica na C?mara Municipal de Manaus. [Masters Thesis]. Universidade Federal do Amazonas; 2018. Available from: https://tede.ufam.edu.br/handle/tede/7535

22. Macchi, Meiggie. Etude de la contribution des motifs dans la spécificité et la diversité fonctionnelles des protéines Hox : Insights into Hox transcription factor function from protein motif usage.

Degree: Docteur es, Biologie du développement, 2016, Aix Marseille Université

URL: http://www.theses.fr/2016AIXM4028

►

Les protéines Hox sont des facteurs de transcription à homéodomaine, dont les propriétés de liaison à l’ADN contrastent avec leur spécificité fonctionnelle in vivo. Ils… (more)

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Les protéines Hox sont des facteurs de transcription à homéodomaine, dont les propriétés de liaison à l’ADN contrastent avec leur spécificité fonctionnelle in vivo. Ils interagissent avec les cofacteurs PBC (Extradenticle (Exd) chez la drosophile) formant des complexes multimériques dont la spécificité fonctionnelle est accrue. Cette interaction repose sur le motif l’hexapeptide (HX), conservé dans la plupart des protéines Hox. Récemment, nous avons identifié le domaine UbdA (UA), spécifique aux protéines Hox de classe centrale Ultrabithorax (Ubx) et AbdominalA (Abd-A), comme un nouveau motif d'interaction avec la protéine Exd. Des analyses in vivo de la contribution de l’HX et de UbdA dans l’activité des protéines Ubx et Abd-A ont indiqué que les protéines Ubx et Abd-A partagent des fonctions (Exd dépendantes et indépendantes), qui ne sont pas médiées par une utilisation identique des motifs protéiques HX et UA.L’objectif de ces travaux est d’analyser les mécanismes moléculaires qui sous-tendent une utilisation ciblée/sélective des motifs protéiques HX et UA de Ubx et de Abd-A en absence du cofacteur connu Exd. Pour cela, des lignées cellulaires S2 DRSC exprimant les protéines Ubx sauvages et mutantes sur les motifs HX et UA, ont été générées et analysées par des expériences de ChIP-Seq. Nos données comparées à celles obtenues précédemment dans l’équipe pour la protéine Abd-A posent les bases permettant d’appréhender la contribution fonctionnelle et l’utilisation sélective des motifs protéiques HX et UA, au-delà de leurs fonctions dans la médiation de l'interaction avec le cofacteur Exd.

Hox proteins are homeodomain-containing transcription factors, whose poor DNA-binding properties contrast with their functional specificity in vivo. They interact with PBC cofactors (Extradenticle (Exd) in Drosophila), forming multimeric complexes with increased functional specificity. This interaction involve a conserved motif called the hexapeptide (HX), found in most Hox proteins. Recently, we the UbdA domain (UA), specific to the central class Hox proteins Ultrabithorax (Ubx) and Abdominal-A (Abd-A), as a novel interaction motif with the Exd protein. In vivo analysis of the HX and UA contributions to Ubx and Abd-A protein activity indicated Ubx and Abd-A shared functions (Exd dependent or independent) do not necessarily rely on a similar use of the HX or UA protein motifs. The aim of this work was to investigate the molecular mechanisms underlying the targeted/selective use of the HX and UA protein motifs in Ubx and Abd-A in the absence of the usual Hox Exd cofactor. For this, S2 DSRC cell lines stably expressing the Ubx protein, as well as HX or UA variants have been generated and analysed by ChiP-Seq experiments. Our data, compared to those previously obtained for Abd-A in the laboratory, set bases for apprehending the functional contribution and selective use of the HX and UA protein motifs, outside their established function in mediating interaction with the Exd cofactor.

Advisors/Committee Members: Graba, Yacine (thesis director), Saurin, Andrew (thesis director).

Subjects/Keywords: Developpement; Facteurs de transcription; Hox; Motifs; M1bp; ARN pol II; Devlopment; Transcription Factors; Hox; Motif; M1bp; RNA pol II; 571

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Macchi, M. (2016). Etude de la contribution des motifs dans la spécificité et la diversité fonctionnelles des protéines Hox : Insights into Hox transcription factor function from protein motif usage. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2016AIXM4028

Chicago Manual of Style (16^th Edition):

Macchi, Meiggie. “Etude de la contribution des motifs dans la spécificité et la diversité fonctionnelles des protéines Hox : Insights into Hox transcription factor function from protein motif usage.” 2016. Doctoral Dissertation, Aix Marseille Université. Accessed February 27, 2021. http://www.theses.fr/2016AIXM4028.

MLA Handbook (7^th Edition):

Macchi, Meiggie. “Etude de la contribution des motifs dans la spécificité et la diversité fonctionnelles des protéines Hox : Insights into Hox transcription factor function from protein motif usage.” 2016. Web. 27 Feb 2021.

Vancouver:

Macchi M. Etude de la contribution des motifs dans la spécificité et la diversité fonctionnelles des protéines Hox : Insights into Hox transcription factor function from protein motif usage. [Internet] [Doctoral dissertation]. Aix Marseille Université 2016. [cited 2021 Feb 27]. Available from: http://www.theses.fr/2016AIXM4028.

Council of Science Editors:

Macchi M. Etude de la contribution des motifs dans la spécificité et la diversité fonctionnelles des protéines Hox : Insights into Hox transcription factor function from protein motif usage. [Doctoral Dissertation]. Aix Marseille Université 2016. Available from: http://www.theses.fr/2016AIXM4028

Tartu University

23. Toomla, Raul. De facto states in the international system: Conditions for (in-)formal engagement .

Degree: 2013, Tartu University

URL: http://hdl.handle.net/10062/35380

► Doktoritöö „De facto states in the international system: Conditions for (in-)formal engagement” uurib rahvusvaheliste suhete ääremaid – de facto riike. Tegemist on üksustega, mis vastavad… (more)

▼ Doktoritöö „De facto states in the international system: Conditions for (in-)formal engagement” uurib rahvusvaheliste suhete ääremaid – de facto riike. Tegemist on üksustega, mis vastavad riigi tunnustele, kuid milledel puudub teiste riikide heakskiit: rahvusvaheline tunnustus. Hoolimata sellest on mõned de facto riigid maailmas ellu jäänud ning suhtlevad teiste, tunnustatud riikidega. Käesoleva töö peamine eesmärk ongi leida tingimusi, mis sellist mitte-formaalset suhtlust põhjustavad. Kuid me ei piirdu ainult tingimuste leidmisega vaid otsime ka kombinatsioone, kuidas need tingimused omavahel sobitudes de facto riike rahvusvahelisse süsteemi kaasata aitavad. Selleks kasutame töös meetodit, mis on jõudsalt järgijaid kogumas, kuid rahvusvaheliste suhete distsipliinis endiselt vähekasutatud – Qualitative Comparative Analysis. Analüüsitavad tingimusi on kokku neli: setsessioon; võimas patroon; inimõigused ning majanduslikud tingimused. Viimased koosnevad omakorda kolmest komponendist: eksport; välisinvesteeringud ning kaubanduspartnerite hulk, mida analüüsitakse eraldi disjunktsiooni ja konjunktsioonina. Tingimusi, milledeni eelmainitud viia võivad on samuti mitu: välisriikide esindused de facto riigis; formaalne tunnustamine ja osalemine rahvusvaheliste organisatsioonide töös. Töö tulemusel selgus, et de facto riikidel on mitteformaalse kaasamise saavutamiseks erinevad teed, samuti võivad erinevad teed viia sama tulemuseni. Piisavate tingimuste kombinatsioonide hulgas on esindatud kõik analüüsitud tingimused, mistõttu saab väita, et nad kõik omavad kombinatsioonis mõne teise tingimusega mõju de facto riikide positsioonile rahvusvahelises süsteemis. Individuaalset mõju omavad tingimused mitte piisavate vaid vajalikena. Eraldi tasub välja tuua majanduslike tingimuste mõju. Käsitletuna konjunktsioonis oli majanduse mõju kaasamisele väike, kuid käsitletuna disjunktsioonina oli mõju märgatav. Üldiselt annab töö de facto riike käsitleva võrdleva raamistiku, mille põhjal saaks teha edasisi sügavamaleminevaid analüüse.; Doctoral dissertation ‘De facto states in the international system: Conditions for (in-)formal engagement’ deals with periphery of international relations – the de facto states. These are entities that fulfil the criteria for statehood but lack the acceptance of other states – international recognition. Despite this several de facto states have survived in the world and are engaging with recognised states. The main purpose of this thesis is to find conditions that cause the informal engagement. But the research is not limited to finding conditions. We also search for combinations of conditions that help de facto states to be involved in the international system. To achieve this goal we use a method that is increasingly gaining popularity but remains little used in the analysis of international relations – Qualitative Comparative Analysis. There are four conditions to be analysed: secession; powerful patron; human rights; and economic conditions. The latter consist in turn from three components: exports…

Subjects/Keywords: rahvusvahelised suhted; de facto riigid; tunnustamine (pol., jur.); international relations; de facto states; recognition (pol.); Qualitative Comparative Analysis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Toomla, R. (2013). De facto states in the international system: Conditions for (in-)formal engagement . (Thesis). Tartu University. Retrieved from http://hdl.handle.net/10062/35380

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Toomla, Raul. “De facto states in the international system: Conditions for (in-)formal engagement .” 2013. Thesis, Tartu University. Accessed February 27, 2021. http://hdl.handle.net/10062/35380.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Toomla, Raul. “De facto states in the international system: Conditions for (in-)formal engagement .” 2013. Web. 27 Feb 2021.

Vancouver:

Toomla R. De facto states in the international system: Conditions for (in-)formal engagement . [Internet] [Thesis]. Tartu University; 2013. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10062/35380.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Toomla R. De facto states in the international system: Conditions for (in-)formal engagement . [Thesis]. Tartu University; 2013. Available from: http://hdl.handle.net/10062/35380

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

24. Stránský, Patrik. Fotovoltaické články pro napájení nízkoodběrových elektronicickych zařízení: Photovoltaic cells for supplying low-consumption electronic devices.

Degree: 2018, Brno University of Technology

URL: http://hdl.handle.net/11012/9626

► Goal of this bachelor thesis is to design the power supply for low-consumption electronic devices based on Lithium-polymer battery, which will be charged by photovoltaic… (more)

Subjects/Keywords: fotovoltaika; solární; článek; napájení; akumulátor; Li-Ion; Li-Pol; photovoltaics; solar; cell; power; supply; accumulator; Li-Ion; Li-Pol

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stránský, P. (2018). Fotovoltaické články pro napájení nízkoodběrových elektronicickych zařízení: Photovoltaic cells for supplying low-consumption electronic devices. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/9626

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Stránský, Patrik. “Fotovoltaické články pro napájení nízkoodběrových elektronicickych zařízení: Photovoltaic cells for supplying low-consumption electronic devices.” 2018. Thesis, Brno University of Technology. Accessed February 27, 2021. http://hdl.handle.net/11012/9626.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Stránský, Patrik. “Fotovoltaické články pro napájení nízkoodběrových elektronicickych zařízení: Photovoltaic cells for supplying low-consumption electronic devices.” 2018. Web. 27 Feb 2021.

Vancouver:

Stránský P. Fotovoltaické články pro napájení nízkoodběrových elektronicickych zařízení: Photovoltaic cells for supplying low-consumption electronic devices. [Internet] [Thesis]. Brno University of Technology; 2018. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/11012/9626.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Stránský P. Fotovoltaické články pro napájení nízkoodběrových elektronicickych zařízení: Photovoltaic cells for supplying low-consumption electronic devices. [Thesis]. Brno University of Technology; 2018. Available from: http://hdl.handle.net/11012/9626

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

The Ohio State University

25. Su, Mei-I. NMR structural studies of African swine fever virus DNA polymerase X complexed with gapped DNA and MgdNTP.

Degree: PhD, Chemistry, 2004, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1080156734

► The African swine fever virus DNA polymerase X (Pol X) is the smallest nucleotidyl transferase identified to date. It has been characterized as the least… (more)

Subjects/Keywords: Pol X; DNA; Pol b; ternary complex; GAPPED DNA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Su, M. (2004). NMR structural studies of African swine fever virus DNA polymerase X complexed with gapped DNA and MgdNTP. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1080156734

Chicago Manual of Style (16^th Edition):

Su, Mei-I. “NMR structural studies of African swine fever virus DNA polymerase X complexed with gapped DNA and MgdNTP.” 2004. Doctoral Dissertation, The Ohio State University. Accessed February 27, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1080156734.

MLA Handbook (7^th Edition):

Su, Mei-I. “NMR structural studies of African swine fever virus DNA polymerase X complexed with gapped DNA and MgdNTP.” 2004. Web. 27 Feb 2021.

Vancouver:

Su M. NMR structural studies of African swine fever virus DNA polymerase X complexed with gapped DNA and MgdNTP. [Internet] [Doctoral dissertation]. The Ohio State University; 2004. [cited 2021 Feb 27]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1080156734.

Council of Science Editors:

Su M. NMR structural studies of African swine fever virus DNA polymerase X complexed with gapped DNA and MgdNTP. [Doctoral Dissertation]. The Ohio State University; 2004. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1080156734

26. Guen, Rahma. Sur l’existence de solutions pour l’équation de van der Pol et pour certaines équations différentielles du second ordre, en présence d’impulsions ; sur la moyennisation pour les équations différentielles floues.

Degree: PhD, Mathématiques, 2016, Université de Sherbrooke

URL: http://www.collectionscanada.gc.ca/obj/thesescanada/vol2/QSHERU/TC-QSHERU-11143_8861.pdf ; http://savoirs.usherbrooke.ca/bitstream/11143/8861/1/Guen_Rahma_PhD_2016.pdf

► Cette thèse est constituée de deux parties : Dans la première partie nous étudions l’existence de solutions périodiques, de periode donnée, et à variations bornées,… (more)

Subjects/Keywords: Équations différentielles; Équations de van der Pol; Équations différentielles floues, moyennisation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Guen, R. (2016). Sur l’existence de solutions pour l’équation de van der Pol et pour certaines équations différentielles du second ordre, en présence d’impulsions ; sur la moyennisation pour les équations différentielles floues. (Doctoral Dissertation). Université de Sherbrooke. Retrieved from http://www.collectionscanada.gc.ca/obj/thesescanada/vol2/QSHERU/TC-QSHERU-11143_8861.pdf ; http://savoirs.usherbrooke.ca/bitstream/11143/8861/1/Guen_Rahma_PhD_2016.pdf

Chicago Manual of Style (16^th Edition):

Guen, Rahma. “Sur l’existence de solutions pour l’équation de van der Pol et pour certaines équations différentielles du second ordre, en présence d’impulsions ; sur la moyennisation pour les équations différentielles floues.” 2016. Doctoral Dissertation, Université de Sherbrooke. Accessed February 27, 2021. http://www.collectionscanada.gc.ca/obj/thesescanada/vol2/QSHERU/TC-QSHERU-11143_8861.pdf ; http://savoirs.usherbrooke.ca/bitstream/11143/8861/1/Guen_Rahma_PhD_2016.pdf.

MLA Handbook (7^th Edition):

Guen, Rahma. “Sur l’existence de solutions pour l’équation de van der Pol et pour certaines équations différentielles du second ordre, en présence d’impulsions ; sur la moyennisation pour les équations différentielles floues.” 2016. Web. 27 Feb 2021.

Vancouver:

Guen R. Sur l’existence de solutions pour l’équation de van der Pol et pour certaines équations différentielles du second ordre, en présence d’impulsions ; sur la moyennisation pour les équations différentielles floues. [Internet] [Doctoral dissertation]. Université de Sherbrooke; 2016. [cited 2021 Feb 27]. Available from: http://www.collectionscanada.gc.ca/obj/thesescanada/vol2/QSHERU/TC-QSHERU-11143_8861.pdf ; http://savoirs.usherbrooke.ca/bitstream/11143/8861/1/Guen_Rahma_PhD_2016.pdf.

Council of Science Editors:

Guen R. Sur l’existence de solutions pour l’équation de van der Pol et pour certaines équations différentielles du second ordre, en présence d’impulsions ; sur la moyennisation pour les équations différentielles floues. [Doctoral Dissertation]. Université de Sherbrooke; 2016. Available from: http://www.collectionscanada.gc.ca/obj/thesescanada/vol2/QSHERU/TC-QSHERU-11143_8861.pdf ; http://savoirs.usherbrooke.ca/bitstream/11143/8861/1/Guen_Rahma_PhD_2016.pdf

UCLA

27. Alhadid, Yazan Khalaf. Single-molecule studies of different steps in human RNA polymerase II and bacterial RNA polymerase transcription.

Degree: Molec, Cell, & Integ Physiology, 2018, UCLA

URL: http://www.escholarship.org/uc/item/1d858964

► Transcription of genomic DNA of all organisms is carried out by members of the multi-subunit RNA polymerase family. Regulation of RNA polymerase localization and activity… (more)

▼ Transcription of genomic DNA of all organisms is carried out by members of the multi-subunit RNA polymerase family. Regulation of RNA polymerase localization and activity underlies cellular homeostasis, division, and response to environmental cues. The catalytic mechanism, overall architecture, and many sequence and structural features of bacterial RNA polymerase are conserved in its Archaeal and Eukaryotic counterparts. The human RNA polymerase II (Pol II) is responsible for transcription of all protein-coding and many non-coding genes. The majority of current knowledge on RNA polymerases and their mechanism at different steps in transcription derives from extensive work done using classical biochemical, genetic and structural biology methods. However, the use of single-molecule approaches addressed crucial questions on the function and mechanism of RNA polymerases during transcription, which were not possible to answer with ensemble-based approaches due to averaging effects. A useful fluorescence-based single-molecule technique to measure distances on the molecular scale and monitor dynamics is F�rster resonance energy transfer (FRET). Here, I report on the development of diffusion-based single-molecule FRET (smFRET) methods to investigate different steps in transcription by the in vitro reconstituted human Pol II system. Using an assay that monitors the FRET changes between fluorescent dyes in the unwound region of promoter DNA (transcription bubble), I demonstrated the effect of certain components of the reconstituted system on the relative size of the transcription bubble. I also detail the optimizations done to enhance the affinity of single-stranded DNA (ssDNA) FRET probes to complementary target sequences. These ssDNA FRET probes were used to investigate the effect of certain components of the reconstituted system on Pol II activity by measuring the relative levels of RNA product. In addition to studies on the Pol II system, I report on the effect of the 5’-group of nascent RNA on the stability of the Escherichia coli RNA polymerase (RNAP) transcription bubble. I show how the presence of a 5’-monophosphate appears to destabilize the open bubble while a 5’-hydroxyl has no effect. Finally, I describe the work done on a project I took part in that identified a previously uncharacterized RNAP paused complex in initiation. We demonstrate that RNAP complexes undergoing initial transcription can enter the inactive paused state by backtracking. I also demonstrate how the presence of a 5’-triphosphate rapidly enhances entrance of RNAP complexes undergoing initial transcription into an inactive paused complex.

Subjects/Keywords: Biochemistry; Biophysics; FRET; Pol II; RNA Polymerase; Single-molecule; Transcription

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Alhadid, Y. K. (2018). Single-molecule studies of different steps in human RNA polymerase II and bacterial RNA polymerase transcription. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/1d858964

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Alhadid, Yazan Khalaf. “Single-molecule studies of different steps in human RNA polymerase II and bacterial RNA polymerase transcription.” 2018. Thesis, UCLA. Accessed February 27, 2021. http://www.escholarship.org/uc/item/1d858964.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Alhadid, Yazan Khalaf. “Single-molecule studies of different steps in human RNA polymerase II and bacterial RNA polymerase transcription.” 2018. Web. 27 Feb 2021.

Vancouver:

Alhadid YK. Single-molecule studies of different steps in human RNA polymerase II and bacterial RNA polymerase transcription. [Internet] [Thesis]. UCLA; 2018. [cited 2021 Feb 27]. Available from: http://www.escholarship.org/uc/item/1d858964.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Alhadid YK. Single-molecule studies of different steps in human RNA polymerase II and bacterial RNA polymerase transcription. [Thesis]. UCLA; 2018. Available from: http://www.escholarship.org/uc/item/1d858964

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

28. Ταβουλάρη, Δέσποινα. Μέθοδοι διαταραχών και εφαρμογές αυτών.

Degree: 2012, University of Patras

URL: http://hdl.handle.net/10889/5935

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Σε αυτή τη διπλωματική εργασία παρουσιάζονται μερικές μέθοδοι ομαλών διαταραχών και η εφαρμογή τους στις "διάσημες" μη γραμμικές συνήθεις διαφορικές εξισώσεις Duffing, Castor και van… (more)

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Σε αυτή τη διπλωματική εργασία παρουσιάζονται μερικές μέθοδοι ομαλών διαταραχών και η εφαρμογή τους στις "διάσημες" μη γραμμικές συνήθεις διαφορικές εξισώσεις Duffing, Castor και van der Pol.Οι μέθοδοι διαταραχών μπορούν να χρησιμοποιηθούν για να βρούμε προσεγγιστικές λύσεις σε διαφορικές εξισώσεις οι οποίες είναι μη γραμμικές και μια ακριβή λύση δεν μπορεί να βρεθεί. Η μέθοδος της θεωρίας διαταραχών γίνεται με σεβασμό ως προς μια μικρή παράμετρο ε, 0<ε<<1. Οι προσεγγιστικές αυτές μέθοδοι προυποθέτουν ότι γνωρίζουμε πλήρως τη λύση του προβλήματος για την τιμή ε=0 μιας παραμέτρου και επιχειρούμε να εκφράσουμε τη γενική λύση, για 0<ε<<1, υπό μορφή σειράς όρων του ε,ε²,...κ.τ.λ.

In this thesis we present some regular perturbation methods and their applications to the famous non-linear ordinary differential equations of Duffing, Castor and van der Pol. The method of perturbations can be used to develop approximate solutions to differential equations, which have nonlinearities or variable coefficients so that an exact solution cannot be constructed. The method of perturbation expansion is carried out with respect to a small parameter ε,0<ε<<1. These approximate methods require that we know the solution of the problem for ε=0 and try to expess the general solution, for 0<ε<<1, as a series of terms ε,ε²,...e.t.c.

Advisors/Committee Members: Πετροπούλου, Ευγενία, Tavoulari, Despina, Κοκολογιαννάκη, Χρυσούλα, Βαν Ντερ Βειλε, Ιάκωβος, Πετροπούλου, Ευγενία.

Subjects/Keywords: Μέθοδοι διαταραχών; 515.392; Perturbation; Van der Pol; Duffing; Castor

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ταβουλάρη, �. (2012). Μέθοδοι διαταραχών και εφαρμογές αυτών. (Masters Thesis). University of Patras. Retrieved from http://hdl.handle.net/10889/5935

Chicago Manual of Style (16^th Edition):

Ταβουλάρη, Δέσποινα. “Μέθοδοι διαταραχών και εφαρμογές αυτών.” 2012. Masters Thesis, University of Patras. Accessed February 27, 2021. http://hdl.handle.net/10889/5935.

MLA Handbook (7^th Edition):

Ταβουλάρη, Δέσποινα. “Μέθοδοι διαταραχών και εφαρμογές αυτών.” 2012. Web. 27 Feb 2021.

Vancouver:

Ταβουλάρη �. Μέθοδοι διαταραχών και εφαρμογές αυτών. [Internet] [Masters thesis]. University of Patras; 2012. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10889/5935.

Council of Science Editors:

Ταβουλάρη �. Μέθοδοι διαταραχών και εφαρμογές αυτών. [Masters Thesis]. University of Patras; 2012. Available from: http://hdl.handle.net/10889/5935

29. Daigneault, Jillian. The Role of NELF in Mediating Human Gene Expression.

Degree: PhD, Cancer Biology, 2017, University of Michigan

URL: http://hdl.handle.net/2027.42/138582

► Transcription is the synthesis of RNA from a DNA template. Transcription has been shown to occur in three main steps, initiation, elongation and termination. Additional… (more)

▼ Transcription is the synthesis of RNA from a DNA template. Transcription has been shown to occur in three main steps, initiation, elongation and termination. Additional regulatory steps include a rate limiting step between initiation and elongation of RNA polymerase II (RNA Pol II) termed promoter-proximal pausing of RNA polymerase. Dysregulation at any stage of this process can lead to cancer development. There has been extensive work focusing on how drastic alterations to the transcription process contributes to cancer development; however, there has been less focus on how the fine-tuning steps of transcription regulation contribute to cancer phenotypes. Specifically, my thesis focuses on understanding the contributions of NELF-mediated pausing to cancer development. To begin, I focused on primary cells in order to better understand the function of NELF-mediated pausing in a normal context. My work has identified a global profile of paused genes in human cells. Following the completion of this profile, I wanted to identify pathways that were enriched for paused genes. I found that paused genes are involved in cancer associated pathways such as EGFR and TGFb signaling as well as general transcription and gene expression. After identifying human genes with paused RNA polymerases, I focused on studying NELF. I found that almost all genes with NELF enrichment are paused. A majority of these genes also require NELF to maintain the pause. I then wanted to investigate the biological consequences of NELF-mediated pausing. I found that the expression of more than half of NELF-mediated paused genes are regulated by NELF. These genes include those involved in the cancer-associated pathways EGFR, TGFb and VEGF signaling. I showed that besides localizing to gene promoters, NELF also targets other genomic regions. I found that approximately half of these sites are in enhancers, specifically those enhancers that are actively transcribed. We showed that the abundance of these eRNAs is dependent on NELF. Finally, we found that loss of transcription of these eRNA result in changes in expression of nearby genes. Upon identifying NELF as a key regulator of gene expression in normal cells, I investigated how this process contributed to the gene expression changes found in cancer. To begin, I identified paused genes in HT29 colorectal cancer cells. I found that many of the same pathways show pausing in both normal cells and cancer cells. I also found that most genes utilize pausing to reduce their expression in cancer cells. These genes were enriched for cellular senescence, cellular stress response and WNT signaling. My work provides insight into the role of RNA Pol II pausing in cancer development. I have shown that cancer-associated pathways, such as EGFR, are regulated by RNA Pol II pausing. I have also generated global profiles of pausing in both normal and cancer cells. In comparing these two profiles, I have identified differences in the function of pausing between normal and cancer cells. One of the key differences I… Advisors/Committee Members: Cheung, Vivian (committee member), Sekiguchi, JoAnn M (committee member), Lawrence, Theodore S (committee member), Day, Mark L (committee member), Fearon, Eric R (committee member), Ferguson, David O (committee member).

Subjects/Keywords: RNA Pol II Pausing; NELF; Genetics; Health Sciences

15 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Daigneault, J. (2017). The Role of NELF in Mediating Human Gene Expression. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/138582

Chicago Manual of Style (16^th Edition):

Daigneault, Jillian. “The Role of NELF in Mediating Human Gene Expression.” 2017. Doctoral Dissertation, University of Michigan. Accessed February 27, 2021. http://hdl.handle.net/2027.42/138582.

MLA Handbook (7^th Edition):

Daigneault, Jillian. “The Role of NELF in Mediating Human Gene Expression.” 2017. Web. 27 Feb 2021.

Vancouver:

Daigneault J. The Role of NELF in Mediating Human Gene Expression. [Internet] [Doctoral dissertation]. University of Michigan; 2017. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2027.42/138582.

Council of Science Editors:

Daigneault J. The Role of NELF in Mediating Human Gene Expression. [Doctoral Dissertation]. University of Michigan; 2017. Available from: http://hdl.handle.net/2027.42/138582

University of Georgia

30. Higgins, Stephen Lane. Methods for predicting flow-induced vibrations in bellows expansion joints.

Degree: 2018, University of Georgia

URL: http://hdl.handle.net/10724/37176

► Bellows expansion joints are a specialty corrugated pipe fixture that serve critical purposes in aeronautics, space, defense and industrial applications. Their corrugated design makes bellows… (more)

Subjects/Keywords: flow; induced; vibrations; bellows; expansion; joint; van der pol; oscillator

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Higgins, S. L. (2018). Methods for predicting flow-induced vibrations in bellows expansion joints. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/37176

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Higgins, Stephen Lane. “Methods for predicting flow-induced vibrations in bellows expansion joints.” 2018. Thesis, University of Georgia. Accessed February 27, 2021. http://hdl.handle.net/10724/37176.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Higgins, Stephen Lane. “Methods for predicting flow-induced vibrations in bellows expansion joints.” 2018. Web. 27 Feb 2021.

Vancouver:

Higgins SL. Methods for predicting flow-induced vibrations in bellows expansion joints. [Internet] [Thesis]. University of Georgia; 2018. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10724/37176.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Higgins SL. Methods for predicting flow-induced vibrations in bellows expansion joints. [Thesis]. University of Georgia; 2018. Available from: http://hdl.handle.net/10724/37176

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations