subject:(Platinum)

Nelson Mandela Metropolitan University

1. Davis, John Christopher. A Speciation study of the chloro-hydroxo complexes of Pt(II).

Degree: Faculty of Science, 2009, Nelson Mandela Metropolitan University

► In this study a method was developed to identify and quantify platinum(II) complexes of the type [PtCl4-n(OH)n]2- and [PtCl4-n(H2O)n]2-n. Separation of the various species was… (more)

▼ In this study a method was developed to identify and quantify platinum(II) complexes of the type [PtCl4-n(OH)n]2- and [PtCl4-n(H2O)n]2-n. Separation of the various species was achieved with the aid of a hyphenated reversed phase HPLC-ICP-MS technique coupled with an ion-pairing reagent, HMHDCl2. The adsorption of HMHD2+ onto a C-18 column was investigated by generating a series of breakthrough curves. It was found that the selectivity for high charge density anions originates from its low surface coverage relative to TBA+, which on the other hand could not separate Pt(II) complexes. The peaks in the chromatographic traces were assigned by following the stepwise ligand substitution of [PtCl4]2- in hydroxide medium with UV/Vis spectrophotometry and HPLC-ICP-MS simultaneously. A computer program was written by the author to analyse chromatographic data by deconvoluting the chromatogram into its individual components and calculating the mole fraction of each component. The validity of the consecutive pseudo-first order model was validated by constructing 3D Mauser diagrams with the raw spectrophotometric data (A1 vs A2 vs A3). Additional software was used to simulate the raw spectrophotometric data and processed chromatographic data. The pseudo-first order rate constants obtained in both cases were in agreement with each other. Hence, peaks were assigned to [PtCl4]2-, [PtCl3(OH)]2-, [PtCl2(OH)2]2-, [PtCl3(H2O)]-. The molar extinction coefficient spectra of [PtCl3(OH)]2- and [PtCl2(OH)2]2- were obtained by simulating the spectrophotometric data at wavelengths from 280 to 450 nm. The reaction of [PtCl4]2- with sodium hydroxide was investigated with UV/Vis spectrophotometry at 25 °C. A rate constant consisting of a first and second order term was obtained. The first order term agreed with what has been reported in the literature for aquation of [PtCl4]2- at 25 degrees C. The influence of temperature was established by conducting the experiment at different temperatures. It was found that the reaction proceeds essentially via aquation at elevated temperatures.

Subjects/Keywords: Platinum; Platinum – Separation; Platinum compounds

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APA (6^th Edition):

Davis, J. C. (2009). A Speciation study of the chloro-hydroxo complexes of Pt(II). (Thesis). Nelson Mandela Metropolitan University. Retrieved from http://hdl.handle.net/10948/1213

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Davis, John Christopher. “A Speciation study of the chloro-hydroxo complexes of Pt(II).” 2009. Thesis, Nelson Mandela Metropolitan University. Accessed March 04, 2021. http://hdl.handle.net/10948/1213.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Davis, John Christopher. “A Speciation study of the chloro-hydroxo complexes of Pt(II).” 2009. Web. 04 Mar 2021.

Vancouver:

Davis JC. A Speciation study of the chloro-hydroxo complexes of Pt(II). [Internet] [Thesis]. Nelson Mandela Metropolitan University; 2009. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10948/1213.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Davis JC. A Speciation study of the chloro-hydroxo complexes of Pt(II). [Thesis]. Nelson Mandela Metropolitan University; 2009. Available from: http://hdl.handle.net/10948/1213

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Nelson Mandela Metropolitan University

2. Jonck, Heine. Development of platinum metal specific separating agents.

Degree: MSc, Faculty of Science, 2008, Nelson Mandela Metropolitan University

URL: http://hdl.handle.net/10948/712

► In this dissertation, the aim was to develop a platinum specific resin to be utilized for the early removal of platinum from the industrial feed… (more)

▼ In this dissertation, the aim was to develop a platinum specific resin to be utilized for the early removal of platinum from the industrial feed solution. Efforts were therefore directed towards the syntheses of silica based resins, with active centra, designed for platinum. The large chlorometallate ions present in the feed stream, were characterized in terms of physical parameters relevant to phase distribution, namely distortability (RD), charge density, softness (σ) etc. Matching cations for each of the types were investigated. In order to attempt the design of platinum specific resins, different structural amines were used to aminate the silicone precursor and to subsequently fix these onto the silica framework. Two different solvents namely alcohol and dmf were used in this process, resulting in two sets of resins, with different properties. The design was based on previous experience with these ions, with reference to their behaviour towards different types of cations. The platinum species, PtCl6 2- and PtCl4 2-, as well as the most important contaminants in the feed stream, were typified, bearing in mind size, charge, charge density and distortability. Different types of cationic centra, having differences in charge density, stereochemical crowding and extent of hydrophobicity, were synthesized and tested-both as solvent extractants (where possible) and silica based resins. The results indicated that, partly screened secondary ammonium cationic resin species, which could be regarded as “intermediate”, proved to be satisfactory both in their high percentage extraction for PtCl4 2- and rejection of contaminants like chlororhodates, chloroiridates(III) and FeCl4 -. It was however necessary, to work at a redox potential, where iridium(IV) in the form of IrCl6 2-, was absent. Various 2-aminoalkane resins were prepared, with variation in the length of alkane group and synthesised by the two different solvents. The latter resulted in two sets of resins with not only differing compactness, but also having significantly different properties with reference to platinum specificity, HCl effect and stripping potential. The 2-aminobutane and 2-aminoheptane resins in particular, proved to be very satisfactory platinum specific resins, both with respect to selectivity, platinum capacity and stripping potential. The various physical parameters could be applied to identify the chemical behaviour of anions and assist in the development of anion specificity for the relevant species Advisors/Committee Members: Du Preez, J G H Prof.

Subjects/Keywords: Platinum; Platinum – Separation

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APA (6^th Edition):

Jonck, H. (2008). Development of platinum metal specific separating agents. (Masters Thesis). Nelson Mandela Metropolitan University. Retrieved from http://hdl.handle.net/10948/712

Chicago Manual of Style (16^th Edition):

Jonck, Heine. “Development of platinum metal specific separating agents.” 2008. Masters Thesis, Nelson Mandela Metropolitan University. Accessed March 04, 2021. http://hdl.handle.net/10948/712.

MLA Handbook (7^th Edition):

Jonck, Heine. “Development of platinum metal specific separating agents.” 2008. Web. 04 Mar 2021.

Vancouver:

Jonck H. Development of platinum metal specific separating agents. [Internet] [Masters thesis]. Nelson Mandela Metropolitan University; 2008. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10948/712.

Council of Science Editors:

Jonck H. Development of platinum metal specific separating agents. [Masters Thesis]. Nelson Mandela Metropolitan University; 2008. Available from: http://hdl.handle.net/10948/712

Oregon State University

3. Johnson, Carolyn Etmo. The determination and recovery of the platinum metals from dilute solution.

Degree: MA, Chemistry, 1939, Oregon State University

URL: http://hdl.handle.net/1957/52997

Subjects/Keywords: Platinum

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APA (6^th Edition):

Johnson, C. E. (1939). The determination and recovery of the platinum metals from dilute solution. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/52997

Chicago Manual of Style (16^th Edition):

Johnson, Carolyn Etmo. “The determination and recovery of the platinum metals from dilute solution.” 1939. Masters Thesis, Oregon State University. Accessed March 04, 2021. http://hdl.handle.net/1957/52997.

MLA Handbook (7^th Edition):

Johnson, Carolyn Etmo. “The determination and recovery of the platinum metals from dilute solution.” 1939. Web. 04 Mar 2021.

Vancouver:

Johnson CE. The determination and recovery of the platinum metals from dilute solution. [Internet] [Masters thesis]. Oregon State University; 1939. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1957/52997.

Council of Science Editors:

Johnson CE. The determination and recovery of the platinum metals from dilute solution. [Masters Thesis]. Oregon State University; 1939. Available from: http://hdl.handle.net/1957/52997

4. Wang, Chao. Size and Shape Controlled Synthesis of Platinum based Nanoparticles and Their Catalysis for Oxygen Reduction Reaction in Fuel Cells.

Degree: PhD, Division of Engineering. Electrical Sciences and Computer Engineering, 2008, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:14/

► Developing nanoparticle (NP) catalyst with controlled size and surface structure is the key to achieve high catalytic efficiency. Of numerous NP catalysts studied, platinum (Pt)… (more)

▼ Developing nanoparticle (NP) catalyst with controlled size and surface structure is the key to achieve high catalytic efficiency. Of numerous NP catalysts studied, platinum (Pt) NPs have attracted particular interest due to their superior catalysis for many chemical reactions, especially for fuel cell reactions including hydrogen oxidation and oxygen reduction. However, Pt is precious and expensive, and thus large-scale applications demand the reduction of Pt usage. This has promoted the search for Pt-based catalysts with higher efficiency. Catalytic properties of Pt NPs strongly depend on their size, shape, and support, which are also the clues for improving the Pt catalyst. For this purpose, size and shape controlled Pt NPs, dumbbell-like Pt-Fe3O4 NPs, and composite Pt-Au NPs have been prepared by organic solution synthesis. Oxygen reduction in fuel cell conditions was used as the model reaction to evaluate the catalytic performance of various Pt based NPs. Pt NPs in cubic, truncated cubic and polyhedral shapes were synthesized for studying the shape-dependent catalysis of Pt. It was found that Pt nanocubes show higher catalytic activity for oxygen reduction reaction (ORR) than the others in sulfuric acid electrolyte. By applying the Pt NPs as seeds, dumbbell-like Pt-Fe3O4 NPs were synthesized by epitaxial growth of Fe on Pt followed by oxidation in air. Electronic structure of Pt in the Pt-Fe3O4 NPs was found to be modified due to the electron transfer from Fe3O4 to Pt. This induces dramatic enhancement of the catalysis of Pt. Stability is another issue for Pt catalyst. Pt can be oxidized and dissolved under potential in fuel cell conditions. Shooting for this, composite Pt-Au NPs were synthesized and catalytic study revealed that Pt became much more stable after conjugation with Au against potential sweeping. Additional work on other nanomaterials will be also presented, including AuAg alloy NPs, Au-Fe3O4 NPs, Au nanowires, and FePt nanorods/nanowires. Advisors/Committee Members: Sun, Shouheng (director), Beresford, Rod (reader), Hurt, Robert (reader), Sweigart, Dwight (reader).

Subjects/Keywords: Platinum

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APA (6^th Edition):

Wang, C. (2008). Size and Shape Controlled Synthesis of Platinum based Nanoparticles and Their Catalysis for Oxygen Reduction Reaction in Fuel Cells. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:14/

Chicago Manual of Style (16^th Edition):

Wang, Chao. “Size and Shape Controlled Synthesis of Platinum based Nanoparticles and Their Catalysis for Oxygen Reduction Reaction in Fuel Cells.” 2008. Doctoral Dissertation, Brown University. Accessed March 04, 2021. https://repository.library.brown.edu/studio/item/bdr:14/.

MLA Handbook (7^th Edition):

Wang, Chao. “Size and Shape Controlled Synthesis of Platinum based Nanoparticles and Their Catalysis for Oxygen Reduction Reaction in Fuel Cells.” 2008. Web. 04 Mar 2021.

Vancouver:

Wang C. Size and Shape Controlled Synthesis of Platinum based Nanoparticles and Their Catalysis for Oxygen Reduction Reaction in Fuel Cells. [Internet] [Doctoral dissertation]. Brown University; 2008. [cited 2021 Mar 04]. Available from: https://repository.library.brown.edu/studio/item/bdr:14/.

Council of Science Editors:

Wang C. Size and Shape Controlled Synthesis of Platinum based Nanoparticles and Their Catalysis for Oxygen Reduction Reaction in Fuel Cells. [Doctoral Dissertation]. Brown University; 2008. Available from: https://repository.library.brown.edu/studio/item/bdr:14/

Michigan State University

5. Zetts, John Stephen, 1942-. A test of the Flynn, Bass and Lazarus theory using quenched platinum.

Degree: PhD, Department of Physics, 1971, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:36577

Subjects/Keywords: Platinum

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APA (6^th Edition):

Zetts, John Stephen, 1. (1971). A test of the Flynn, Bass and Lazarus theory using quenched platinum. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:36577

Chicago Manual of Style (16^th Edition):

Zetts, John Stephen, 1942-. “A test of the Flynn, Bass and Lazarus theory using quenched platinum.” 1971. Doctoral Dissertation, Michigan State University. Accessed March 04, 2021. http://etd.lib.msu.edu/islandora/object/etd:36577.

MLA Handbook (7^th Edition):

Zetts, John Stephen, 1942-. “A test of the Flynn, Bass and Lazarus theory using quenched platinum.” 1971. Web. 04 Mar 2021.

Vancouver:

Zetts, John Stephen 1. A test of the Flynn, Bass and Lazarus theory using quenched platinum. [Internet] [Doctoral dissertation]. Michigan State University; 1971. [cited 2021 Mar 04]. Available from: http://etd.lib.msu.edu/islandora/object/etd:36577.

Council of Science Editors:

Zetts, John Stephen 1. A test of the Flynn, Bass and Lazarus theory using quenched platinum. [Doctoral Dissertation]. Michigan State University; 1971. Available from: http://etd.lib.msu.edu/islandora/object/etd:36577

Montana State University

6. Dunham, Stephen Oliver. The synthesis of one-dimensional platinum complexes : mechanistic studies from multinuclear NMR.

Degree: PhD, College of Letters & Science, 1992, Montana State University

URL: https://scholarworks.montana.edu/xmlui/handle/1/6873

Subjects/Keywords: Platinum.

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APA (6^th Edition):

Dunham, S. O. (1992). The synthesis of one-dimensional platinum complexes : mechanistic studies from multinuclear NMR. (Doctoral Dissertation). Montana State University. Retrieved from https://scholarworks.montana.edu/xmlui/handle/1/6873

Chicago Manual of Style (16^th Edition):

Dunham, Stephen Oliver. “The synthesis of one-dimensional platinum complexes : mechanistic studies from multinuclear NMR.” 1992. Doctoral Dissertation, Montana State University. Accessed March 04, 2021. https://scholarworks.montana.edu/xmlui/handle/1/6873.

MLA Handbook (7^th Edition):

Dunham, Stephen Oliver. “The synthesis of one-dimensional platinum complexes : mechanistic studies from multinuclear NMR.” 1992. Web. 04 Mar 2021.

Vancouver:

Dunham SO. The synthesis of one-dimensional platinum complexes : mechanistic studies from multinuclear NMR. [Internet] [Doctoral dissertation]. Montana State University; 1992. [cited 2021 Mar 04]. Available from: https://scholarworks.montana.edu/xmlui/handle/1/6873.

Council of Science Editors:

Dunham SO. The synthesis of one-dimensional platinum complexes : mechanistic studies from multinuclear NMR. [Doctoral Dissertation]. Montana State University; 1992. Available from: https://scholarworks.montana.edu/xmlui/handle/1/6873

Montana State University

7. Marvin, John Raymond. Spectroscopic investigation of di-u-hydroxo bridged platinum complexes.

Degree: PhD, College of Letters & Science, 1997, Montana State University

URL: https://scholarworks.montana.edu/xmlui/handle/1/7767

Subjects/Keywords: Platinum.

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APA (6^th Edition):

Marvin, J. R. (1997). Spectroscopic investigation of di-u-hydroxo bridged platinum complexes. (Doctoral Dissertation). Montana State University. Retrieved from https://scholarworks.montana.edu/xmlui/handle/1/7767

Chicago Manual of Style (16^th Edition):

Marvin, John Raymond. “Spectroscopic investigation of di-u-hydroxo bridged platinum complexes.” 1997. Doctoral Dissertation, Montana State University. Accessed March 04, 2021. https://scholarworks.montana.edu/xmlui/handle/1/7767.

MLA Handbook (7^th Edition):

Marvin, John Raymond. “Spectroscopic investigation of di-u-hydroxo bridged platinum complexes.” 1997. Web. 04 Mar 2021.

Vancouver:

Marvin JR. Spectroscopic investigation of di-u-hydroxo bridged platinum complexes. [Internet] [Doctoral dissertation]. Montana State University; 1997. [cited 2021 Mar 04]. Available from: https://scholarworks.montana.edu/xmlui/handle/1/7767.

Council of Science Editors:

Marvin JR. Spectroscopic investigation of di-u-hydroxo bridged platinum complexes. [Doctoral Dissertation]. Montana State University; 1997. Available from: https://scholarworks.montana.edu/xmlui/handle/1/7767

University of British Columbia

8. Phillips, George Lindsay. A study of platinum glyoxime as a suitable substance for the estimation of the atomic weight of the metal.

Degree: MA- MA, Chemistry, 1938, University of British Columbia

URL: http://hdl.handle.net/2429/38688

[No abstract available]

Subjects/Keywords: Platinum

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APA (6^th Edition):

Phillips, G. L. (1938). A study of platinum glyoxime as a suitable substance for the estimation of the atomic weight of the metal. (Masters Thesis). University of British Columbia. Retrieved from http://hdl.handle.net/2429/38688

Chicago Manual of Style (16^th Edition):

Phillips, George Lindsay. “A study of platinum glyoxime as a suitable substance for the estimation of the atomic weight of the metal.” 1938. Masters Thesis, University of British Columbia. Accessed March 04, 2021. http://hdl.handle.net/2429/38688.

MLA Handbook (7^th Edition):

Phillips, George Lindsay. “A study of platinum glyoxime as a suitable substance for the estimation of the atomic weight of the metal.” 1938. Web. 04 Mar 2021.

Vancouver:

Phillips GL. A study of platinum glyoxime as a suitable substance for the estimation of the atomic weight of the metal. [Internet] [Masters thesis]. University of British Columbia; 1938. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2429/38688.

Council of Science Editors:

Phillips GL. A study of platinum glyoxime as a suitable substance for the estimation of the atomic weight of the metal. [Masters Thesis]. University of British Columbia; 1938. Available from: http://hdl.handle.net/2429/38688

University of Waikato

9. Sutton, Ryan. The synthesis of water-soluble analogues of Pt₂(μ₂-S)₂(PPh₃)₄ .

Degree: 2019, University of Waikato

URL: http://hdl.handle.net/10289/12443

► Platinum has a very rich chemistry with sulfur, and this field has been extensively studied. Of particular interest are complexes containing the {Pt₂(μ₂-S)₂} core, comprising… (more)

▼ Platinum has a very rich chemistry with sulfur, and this field has been extensively studied. Of particular interest are complexes containing the {Pt₂(μ₂-S)₂} core, comprising two platinum atoms with μ₂-sulfurs bridging through a flexible hinge. These complexes can act as potent metalloligands (through the two sulfurs) toward a wide range of transition metal and other centres, allowing for the synthesis of complexes with trinuclear mixed-metal cores {Pt₂(μ₃-S)₂M} (M = heterometal). The {Pt₂(μ₂-S)₂} core is also highly nucleophilic and alkylated by the mildest of reagents. The ancillary ligands coordinated to the {Pt₂(μ₂-S)₂} core are primarily triphenylphosphine (PPh₃), resulting in the complexes being significantly insoluble in water, preventing any forms of bioactivity or biphasic catalysis from being assessed. This research project has widened the scope of {Pt₂(μ₂-S)₂} complexes via the synthesis of the new water-soluble complexes {Pt₂(μ₂-S)₂}(PTA)₄, [Pt₂(μ₃- S)₂(PTA)₄Rh(cod)]Cl, and [Pt₃(μ3-S)₂(PTA)6]²⁺ (PTA = 1,3,5-triaza-7- phosphaadamantane, cod = 1,5-cyclooctadiene) that were characterised by electrospray ionisation mass spectrometry (ESI-MS) and phosphorus-31 nuclear magnetic resonance spectroscopy (³¹P{¹H} NMR). The complex [Pt₃(μ₃- S)₂(PTA)₆]²⁺ was synthesised during the research into the use of a sulfide exchange column as an alternative source of sulfide for the synthesis of Pt₂(μ₂- S)₂(PTA)₄. The water-soluble phosphine ligands tris(2-carboxyethyl)phosphine (TCEP) and monosulfonated triphenylphosphine [TPPMS]⁻ were determined to be unsuitable ligands for complexes of the general form {Pt₂(μ₂-S)₂}(L)₄ (L = TCEP, [TPPMS]⁻). During these attempted syntheses the complex {Pt₂(μ₂-S)₂} (cod)₂ was successfully produced and characterised with ESI-MS, ¹H NMR, ¹H-¹H COSY, and ¹³C-¹H HSQC (Proton nuclear magnetic resonance spectroscopy, Correlation Spectroscopy, Heteronuclear Single Quantum Coherence). The use of thioacetamide (CH₂C(S)NH₂) as an alternative source of sulfide in the synthesis of {Pt₂(μ₂-S)₂}(PPh₃)₄ was found to be a poor substitute for the well established Na₂S·9H₂O. The reaction does result in [Pt(CH₃C(S)NH)(PPh₃)₂]⁺+, subsequently isolated as the BPh₄- salt, [Pt(CH₃C(S)NH)(PPh₃)₂](BPh₄) and was characterised by ESI-MS and ³¹P{1H} NMR. The X-ray crystal structure of the by-product trans-Pt(SC(O)CH₃)₂(PPh₃)₂ was obtained. Advisors/Committee Members: Henderson, William (advisor).

Subjects/Keywords: Chemistry; Platinum; Pt2S2

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APA (6^th Edition):

Sutton, R. (2019). The synthesis of water-soluble analogues of Pt₂(μ₂-S)₂(PPh₃)₄ . (Masters Thesis). University of Waikato. Retrieved from http://hdl.handle.net/10289/12443

Chicago Manual of Style (16^th Edition):

Sutton, Ryan. “The synthesis of water-soluble analogues of Pt₂(μ₂-S)₂(PPh₃)₄ .” 2019. Masters Thesis, University of Waikato. Accessed March 04, 2021. http://hdl.handle.net/10289/12443.

MLA Handbook (7^th Edition):

Sutton, Ryan. “The synthesis of water-soluble analogues of Pt₂(μ₂-S)₂(PPh₃)₄ .” 2019. Web. 04 Mar 2021.

Vancouver:

Sutton R. The synthesis of water-soluble analogues of Pt₂(μ₂-S)₂(PPh₃)₄ . [Internet] [Masters thesis]. University of Waikato; 2019. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10289/12443.

Council of Science Editors:

Sutton R. The synthesis of water-soluble analogues of Pt₂(μ₂-S)₂(PPh₃)₄ . [Masters Thesis]. University of Waikato; 2019. Available from: http://hdl.handle.net/10289/12443

Victoria University of Wellington

10. Hasenöhrl, Christoph Roland. Shape and Size Control of Bimetallic PtX (X = Au, Ni, Sn) Nanoparticles.

Degree: 2016, Victoria University of Wellington

URL: http://hdl.handle.net/10063/9093

► Nanoparticles show interesting and novel properties compared to their bulk materials. These properties range from optical, magnetic, electronic to catalytic and can be influenced by… (more)

▼ Nanoparticles show interesting and novel properties compared to their bulk materials. These properties range from optical, magnetic, electronic to catalytic and can be influenced by shape, size and elemental composition. As the ability to control nanoparticle morphology is important in materials science these particles are actively researched. Moreover, by combining different metals multiple properties intrinsic to those elements can be accessed within a single system. This thesis describes general synthetic approaches and underlying theory in the formation of nanoparticles. Focusing on organic solution phase synthesis, pathways to control both size and shape of nanoparticles are discussed. The concept behind the formation and possible structures of bimetallic nanoparticles are explained. Additionally, a brief overview about used characterisation techniques such as transmission electron microscopy and x-ray diffraction are given. Metallic nanoparticles were formed using the organic solution phase synthesis within Fischer-Porter bottles. Elevated temperatures and the presence of hydrogen lead to thermal decomposition of the metallic precursor, reduction of formed metal ions and subsequent build-up of nanoparticles. For bimetallic nanoparticles the seed mediated growth technique is commonly used. By utilizing this technique bimetallic AuPt nanoparticles were formed. The impact of different surfactants, hydrogen pressure, precursors and reaction time upon the size, elemental composition and morphology of these bimetallic AuPt nanoparticles is investigated. The bimetallic structure is evaluated and experiments to control the growth of platinum onto the seed structures are conducted. Further research deals with the formation of hexagonal close packed (hcp) nickel nanoparticles. By altering the surfactant type and concentration nickel favours to crystallise in its hcp modification rather than its most common face-centred cubic (fcc) phase. It was found that nickel packing in this hcp crystal system is forming hourglass-shaped nanoparticles. These particles are further used in seed mediated growth experiments with a platinum precursor to achieve bimetallic nanoparticles to both exploit the catalytic activity of platinum as well as the magnetic moment of nickel. It is shown that the choice of reaction conditions is crucial to achieve growth onto the nickel surface. Moreover, it was found that these nanoparticles are only selectively coated by platinum on hcp {001} facets leading to exposure of both nickel and platinum surfaces. The key results are summarised and the exploited parameters evaluated. Also, perspectives for future research are discussed and a brief outlook for the application of the investigated bimetallic systems is given. Bimetallic tin-platinum nanoparticles were formed by coreduction of the respective tin and platinum containing metal precursors. Several metal sources for both tin and platinum were investigated upon their decomposition and the resulting nanoparticle shape and elemental composition. The… Advisors/Committee Members: Coles, Martyn, Tilley, Richard.

Subjects/Keywords: Nanoparticles; Bimetallics; Platinum

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APA (6^th Edition):

Hasenöhrl, C. R. (2016). Shape and Size Control of Bimetallic PtX (X = Au, Ni, Sn) Nanoparticles. (Doctoral Dissertation). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/9093

Chicago Manual of Style (16^th Edition):

Hasenöhrl, Christoph Roland. “Shape and Size Control of Bimetallic PtX (X = Au, Ni, Sn) Nanoparticles.” 2016. Doctoral Dissertation, Victoria University of Wellington. Accessed March 04, 2021. http://hdl.handle.net/10063/9093.

MLA Handbook (7^th Edition):

Hasenöhrl, Christoph Roland. “Shape and Size Control of Bimetallic PtX (X = Au, Ni, Sn) Nanoparticles.” 2016. Web. 04 Mar 2021.

Vancouver:

Hasenöhrl CR. Shape and Size Control of Bimetallic PtX (X = Au, Ni, Sn) Nanoparticles. [Internet] [Doctoral dissertation]. Victoria University of Wellington; 2016. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10063/9093.

Council of Science Editors:

Hasenöhrl CR. Shape and Size Control of Bimetallic PtX (X = Au, Ni, Sn) Nanoparticles. [Doctoral Dissertation]. Victoria University of Wellington; 2016. Available from: http://hdl.handle.net/10063/9093

East Carolina University

11. McAteer, Donald. Platinum-Catalyzed Acylation of 2-(aryloxy)pyridines Via Direct Carbon-Hydrogen Activation.

Degree: MS, MS-Chemistry, 2017, East Carolina University

URL: http://hdl.handle.net/10342/6186

► Carbonyl groups are ubiquitous in pharmaceuticals, biomolecules, and natural products. The traditional means of acylation to introduce carbonyls, such as the Friedel-Crafts acylation, can be… (more)

Subjects/Keywords: Platinum catalysts; Acylation

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APA (6^th Edition):

McAteer, D. (2017). Platinum-Catalyzed Acylation of 2-(aryloxy)pyridines Via Direct Carbon-Hydrogen Activation. (Masters Thesis). East Carolina University. Retrieved from http://hdl.handle.net/10342/6186

Chicago Manual of Style (16^th Edition):

McAteer, Donald. “Platinum-Catalyzed Acylation of 2-(aryloxy)pyridines Via Direct Carbon-Hydrogen Activation.” 2017. Masters Thesis, East Carolina University. Accessed March 04, 2021. http://hdl.handle.net/10342/6186.

MLA Handbook (7^th Edition):

McAteer, Donald. “Platinum-Catalyzed Acylation of 2-(aryloxy)pyridines Via Direct Carbon-Hydrogen Activation.” 2017. Web. 04 Mar 2021.

Vancouver:

McAteer D. Platinum-Catalyzed Acylation of 2-(aryloxy)pyridines Via Direct Carbon-Hydrogen Activation. [Internet] [Masters thesis]. East Carolina University; 2017. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10342/6186.

Council of Science Editors:

McAteer D. Platinum-Catalyzed Acylation of 2-(aryloxy)pyridines Via Direct Carbon-Hydrogen Activation. [Masters Thesis]. East Carolina University; 2017. Available from: http://hdl.handle.net/10342/6186

Victoria University of Wellington

12. Koedyk, David J. Coordination Chemistry of Phosphinocarbonyls with Platinum.

Degree: 2012, Victoria University of Wellington

URL: http://hdl.handle.net/10063/2033

► This thesis reports the coordination chemistry of phosphinocarbonyl ligands with platinum and describes the influence of phosphine substituents on the mechanism of chelation and the… (more)

▼ This thesis reports the coordination chemistry of phosphinocarbonyl ligands with platinum and describes the influence of phosphine substituents on the mechanism of chelation and the coordination mode of the carbonyl moiety. The ligands synthesised were 2-diphenylphosphinobenzaldehyde (1), 2-diphenylphosphinoacetophenone (2), 2-bis(pentafluorophenyl)phosphinobenzaldehyde (3), and 2-di-tert-butylphosphinobenzaldehyde (4). Compounds 1, 3, and 4 were selected on the basis of their steric bulk and extent to which they donate electron density to the metal. Compound 2 contained the same phosphine substituents to 1, but is the methyl ketone analogue and therefore does not contain the CHO moiety. The cone angle and electronic parameter of compounds 1–4 were compared to the reported values of PPh3, PPh(C6F5)2, and PPhtBu2. Compounds 3 and 4 were similarly bulky, and had larger cone angles than 1. The electron donating capacity of compound 4 was greater than that of 1, and compound 3 was the least electron donating. A new synthetic method for the preparation of 4 is also reported. The coordination chemistry of ligands 1–4 was investigated with platinum(II) and platinum(0) starting materials to assess the influence of the steric and electronic parameters of the phosphine on the chelation of the ligand through the carbonyl to platinum. Coordination of the ligand went through the initial coordination of the phosphine and, depending on the identity of that phosphine, may be followed by chelation of the carbonyl moiety to form a P,C chelate. However, the site of the platinum–carbon bond in the P,C metallacycle depends on the ligand employed. Coordination of the phosphinoaldehyde ligands 1, 3, and 4 produced Pt-C bonds via the C-H activation of the aldehyde CHO group whereas for ketophosphine 2, C-H activation occurred at the α-methyl group. The rate at which C-H activation occurred increased with increasing electron donation from the phosphorus to platinum. Compound 4 chelates to platinum more rapidly than compound 1, while 3 did not undergo chelation at room temperature. Although chelation was only observed to occur via C-H activation, the final products of the coordination reactions of 1–4 with platinum starting materials differed depending on the identity of the ligand. The C-H activation of two molecules of 1 with platinum(II) or platinum(0) produced a platina-β-diketone, cis-[Pt(P,C-2-PPh2C6H4CO)2] (21), which is capable of coordinating to H+, Li+, BF2 +, and [Rh(1,5-cyclooctadiene)]+ between the mutually cis carbonyl groups. One carbonyl moiety of 21 can also undergo condensation with primary amines and ammonia to produce platina-β-ketoimine complexes. The ketone moiety of ligand 2 reacted with platinum(II) starting materials through C-H activation of the terminal methyl group to form the six-membered bis-chelate complex analogous to complex 21. The reaction of 2 with platinum(0) starting materials resulted in the formation of a platinum hydride intermediate which mediated chelation through the partial reduction of the ketone… Advisors/Committee Members: Spencer, John L.

Subjects/Keywords: Platinum; Metallacycle; Phosphinoaldehyde

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APA (6^th Edition):

Koedyk, D. J. (2012). Coordination Chemistry of Phosphinocarbonyls with Platinum. (Masters Thesis). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/2033

Chicago Manual of Style (16^th Edition):

Koedyk, David J. “Coordination Chemistry of Phosphinocarbonyls with Platinum.” 2012. Masters Thesis, Victoria University of Wellington. Accessed March 04, 2021. http://hdl.handle.net/10063/2033.

MLA Handbook (7^th Edition):

Koedyk, David J. “Coordination Chemistry of Phosphinocarbonyls with Platinum.” 2012. Web. 04 Mar 2021.

Vancouver:

Koedyk DJ. Coordination Chemistry of Phosphinocarbonyls with Platinum. [Internet] [Masters thesis]. Victoria University of Wellington; 2012. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10063/2033.

Council of Science Editors:

Koedyk DJ. Coordination Chemistry of Phosphinocarbonyls with Platinum. [Masters Thesis]. Victoria University of Wellington; 2012. Available from: http://hdl.handle.net/10063/2033

University of Missouri – Columbia

13. Moody, Morgan A. Sythesis, characterization and reactivity of platinum (II) peroxo, alkoxide and triflate compunds.

Degree: 2012, University of Missouri – Columbia

URL: http://hdl.handle.net/10355/36761

► [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The chemistry of a collection of platinum(II) compounds, including peroxo, alkoxide and triflate compounds, were… (more)

Subjects/Keywords: platinum chemistry; alkenes

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APA (6^th Edition):

Moody, M. A. (2012). Sythesis, characterization and reactivity of platinum (II) peroxo, alkoxide and triflate compunds. (Thesis). University of Missouri – Columbia. Retrieved from http://hdl.handle.net/10355/36761

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Moody, Morgan A. “Sythesis, characterization and reactivity of platinum (II) peroxo, alkoxide and triflate compunds.” 2012. Thesis, University of Missouri – Columbia. Accessed March 04, 2021. http://hdl.handle.net/10355/36761.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Moody, Morgan A. “Sythesis, characterization and reactivity of platinum (II) peroxo, alkoxide and triflate compunds.” 2012. Web. 04 Mar 2021.

Vancouver:

Moody MA. Sythesis, characterization and reactivity of platinum (II) peroxo, alkoxide and triflate compunds. [Internet] [Thesis]. University of Missouri – Columbia; 2012. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10355/36761.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Moody MA. Sythesis, characterization and reactivity of platinum (II) peroxo, alkoxide and triflate compunds. [Thesis]. University of Missouri – Columbia; 2012. Available from: http://hdl.handle.net/10355/36761

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cincinnati

14. Ringo, Jessica M. Square planar d8 metal complexes with nitrogen-based ligands: structural analysis, metal-metal cooperativity, and applications.

Degree: PhD, Arts and Sciences: Chemistry, 2019, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1562842509907911

► This dissertation focuses on square planar platinum (II) and palladium (II) complexes. Specifically, complexes bearing the 1,4,7-trithiacyclononane ligand were examined to identify a structure correlation.… (more)

▼ This dissertation focuses on square planar platinum (II) and palladium (II) complexes. Specifically, complexes bearing the 1,4,7-trithiacyclononane ligand were examined to identify a structure correlation. The reducing capacity of thiols was explored by electrochemical methods using a mercury thin film electrode and spectroscopically via UV-visible absorption spectroscopy using a platinum dye upon reaction with thiol. Mononuclear, dinuclear, and trinuclear platinum and palladium macrocyclic complexes were synthesized and characterized. An educational workshop for students entering ninth grade is presented using platinum sensors from ongoing research projects. A search of the Cambridge Structural Database was conducted for platinum and palladium structures containing 1,4,7-trithiacyclononane. These structures were analyzed using a variety of methods to determine a structure correlation. They were plotted along the Berry pseudorotation coordinate, the percent deviation from ideal square pyramidal and trigonal bipyramidal geometries was calculated, and t5 values were calculated. This indicated that most structures lie in the square pyramidal region, with more palladium structures closer to trigonal bipyramidal. It was found that the donor or acceptor properties of the ancillary ligands influence the interaction between metal and axial sulfur. The palladium structures show interesting results. When plotted along the platinum trendline, it becomes apparent that most of the palladium structures lie above the platinum trendline. This suggests that for a given M•••Sax distance, the palladium atom undergoes a greater displacement from the plane. This may be a result of the palladium structures having a shallower potential energy surface along the square pyramidal distortion coordinate. To streamline the evaluation of candidate reagents to identify targets for hair care applications, strategies were developed for assessing the reducing properties of thiols. The electrochemical techniques used at the mercury thin film electrode include cyclic voltammetry, differential pulse voltammetry, and differential stripping pulse voltammetry. These techniques do not always give completely reversible results, and show multiple anodic waves in some cases, causing interpretation to be challenging. Another method used was indirect measure of the reducing properties of the thiol by observing the absorbance maximum (?max) of a charge transfer (CT) band for the platinum-thiolate complex. The synthesis and characterization of platinum and palladium complexes with an azamacrocyclic ligand, bis-para-xylylBISDIEN, are reported. This ligand was chosen for its ability to incorporate two metal centers so that dinuclear complexes could be synthesized for multi-electron transfer purposes. Five complexes using this ligand are reported, including the first mononuclear complexes of this architecture. A workshop for students entering ninth grade is presented with the goal of engaging them with real research projects. The structure of the workshop was… Advisors/Committee Members: Guan, Hairong (Committee Chair).

Subjects/Keywords: Chemistry; platinum,sensors

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APA (6^th Edition):

Ringo, J. M. (2019). Square planar d8 metal complexes with nitrogen-based ligands: structural analysis, metal-metal cooperativity, and applications. (Doctoral Dissertation). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1562842509907911

Chicago Manual of Style (16^th Edition):

Ringo, Jessica M. “Square planar d8 metal complexes with nitrogen-based ligands: structural analysis, metal-metal cooperativity, and applications.” 2019. Doctoral Dissertation, University of Cincinnati. Accessed March 04, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1562842509907911.

MLA Handbook (7^th Edition):

Ringo, Jessica M. “Square planar d8 metal complexes with nitrogen-based ligands: structural analysis, metal-metal cooperativity, and applications.” 2019. Web. 04 Mar 2021.

Vancouver:

Ringo JM. Square planar d8 metal complexes with nitrogen-based ligands: structural analysis, metal-metal cooperativity, and applications. [Internet] [Doctoral dissertation]. University of Cincinnati; 2019. [cited 2021 Mar 04]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1562842509907911.

Council of Science Editors:

Ringo JM. Square planar d8 metal complexes with nitrogen-based ligands: structural analysis, metal-metal cooperativity, and applications. [Doctoral Dissertation]. University of Cincinnati; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1562842509907911

University of KwaZulu-Natal

15. Nxumalo, Mthobisi Ian. A kinetic and mechanistic study of cyclic amine functionalized platinum(II) complexes with bio-relevant nitrogen nucleophiles.

Degree: 2018, University of KwaZulu-Natal

URL: https://researchspace.ukzn.ac.za/handle/10413/17460

► In this study, four square-planar platinum(II) complexes were synthesized namely C1S1, C2S1, C3S1 and C4S1. The novel platinum(II) complex (C4S1) was synthesized using methods detailed… (more)

▼ In this study, four square-planar platinum(II) complexes were synthesized namely C1S1, C2S1, C3S1 and C4S1. The novel platinum(II) complex (C4S1) was synthesized using methods detailed in Chapter 4 and characterized using NMR spectroscopy, mass spectroscopy and elemental analysis. The kinetics of the chloride ligand substitution from a series of square-planar platinum(II) complexes named above were investigated using a series of five-membered heterocyclic neutral nitrogen-donor nucleophiles: Imidazole (Im), Pyrazole (Pyz), 1methylImidazole (1-MIm) and L-Histidine (His) in an aqueous solution of constant ionic strength. The kinetics of chloride substitution were investigated as a function nucleophile concentration and temperature under pseudo first-order conditions using UV/Visible spectrophotometry and stopped-flow spectrophotometric techniques. The observed pseudo first-order rate constants obeyed the simple rate law, kobs = k2[Nu]. The observed rate constants along with activation parameters obtained i.e. low activation enthalpies and large, negative activation entropies support an associative mechanism. The data obtained shows that the reactivity of these complexes are influenced by both electronic and steric effects with steric effects being the dominant factor contributing to the overall trend. The kinetic results also show that appended cyclic amine pendant, trans to the leaving chloride group acts as a σ-donor into the terpyridine chelate ligand and is effective only up to the first cyclic amine. The change of the appended cyclic amine to another e.g. from pyrrolidine of C2S1 to piperidine of C1S1 shows that the inductive σdonor ability of the cyclic amine pendant no longer controls the reactivity of the metal centre. The substitution reactivity of the complexes with cyclic amines pendant (C1S1, C2S1 and C3S1) are controlled by the steric influence of the appended cyclic amine which decreases as the cyclic amine pendant gets larger in size, C3S1 < C1S1 < C2S1. This in turn blocks the metal center hence lowering the affinity for the incoming azole nucleophile. The results further support that, the slightest modifications to the terpy moiety leads to changes in the reactivity. The overall trend in the rate of chloride substitution is: C4S1 > C2S1 > C1S1 > C3S1. The observed reactivity trends were supported by density functional theory (DFT) calculation (dipole moment, HOMO-LUMO energy gap, electrophilicity index etc.). In addition, the substitution kinetics was influenced solely by the basicity of the incoming azole nucleophile. The order of reactivity of the nucleophiles with the complexes is in the form, 1-MIm > Im > His > Pyz. Advisors/Committee Members: Reddy, Desigan. (advisor).

Subjects/Keywords: Platinum (II) complexes.; Platinum chemistry.; Platinum antitumour complex.; Anticancer drugs.

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APA (6^th Edition):

Nxumalo, M. I. (2018). A kinetic and mechanistic study of cyclic amine functionalized platinum(II) complexes with bio-relevant nitrogen nucleophiles. (Thesis). University of KwaZulu-Natal. Retrieved from https://researchspace.ukzn.ac.za/handle/10413/17460

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nxumalo, Mthobisi Ian. “A kinetic and mechanistic study of cyclic amine functionalized platinum(II) complexes with bio-relevant nitrogen nucleophiles.” 2018. Thesis, University of KwaZulu-Natal. Accessed March 04, 2021. https://researchspace.ukzn.ac.za/handle/10413/17460.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nxumalo, Mthobisi Ian. “A kinetic and mechanistic study of cyclic amine functionalized platinum(II) complexes with bio-relevant nitrogen nucleophiles.” 2018. Web. 04 Mar 2021.

Vancouver:

Nxumalo MI. A kinetic and mechanistic study of cyclic amine functionalized platinum(II) complexes with bio-relevant nitrogen nucleophiles. [Internet] [Thesis]. University of KwaZulu-Natal; 2018. [cited 2021 Mar 04]. Available from: https://researchspace.ukzn.ac.za/handle/10413/17460.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nxumalo MI. A kinetic and mechanistic study of cyclic amine functionalized platinum(II) complexes with bio-relevant nitrogen nucleophiles. [Thesis]. University of KwaZulu-Natal; 2018. Available from: https://researchspace.ukzn.ac.za/handle/10413/17460

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

North-West University

16. Vos, Amelda. Evaluation of exposure to airborne soluble platinum in a precious metal refinery during non–routine operations / Amelda Vos .

Degree: 2011, North-West University

URL: http://hdl.handle.net/10394/7601

► Background: Platinum refinery workers are exposed to various elements during the refining process, with soluble platinum salts posing a potential health risk. Platinum salts are… (more)

▼ Background: Platinum refinery workers are exposed to various elements during the refining process, with soluble platinum salts posing a potential health risk. Platinum salts are extremely potent sensitisers that can result in the clinical syndrome of platinum salt sensitivity (PSS) that leads to skin and respiratory hypersensitivity in refinery workers. Several published research articles document refinery workers’ exposure levels to soluble platinum salts during production. However, the exposure levels to soluble platinum salts during non–routine stock take activities are unknown although cases of sensitisation have been diagnosed following these nonoperational periods. Stock take for the platinum refinery under study commenced on 18 January 2010 and ended 22 February 2010. Increased emphasis was placed on flushing plant equipment rather than dismantling it. The aim was to dismantle 10% of what previously was dismantled to reduce the risk of exposing employees to soluble platinum salts, to reduce the chance of damaging plant equipment and for cost and time saving purposes. Aim: The objectives of this study are to: (i) quantify work area and personal exposure levels; (ii) identify work areas and work practices with exposure levels exceeding the occupational exposure limit (OEL) (>2 ug/m3); (iii) determine whether exposure levels differ significantly between: a) personal sampling groups (engineering versus production), b) area sampling groups (open versus closed–face sampling), c) work areas, d) total area and total personal sampling groups and to (iv) evaluate the efficiency of the current control measures utilised. Design and Method: A total of 58 platinum samples were collected, consisting of 38 personal and 20 area samples. Personal sampling consisted of Institute of Occupational Medicine (IOM) samplers housing reusable 25 mm filter cassettes with mixed cellulose ester (MCE) membrane filters for the collection of inhalable airborne particles. Because both the cassette and the filter were pre and post–weighed as a single unit, all particles collected (even those against the walls of the cassette) were included in the analysis. Sampling was conducted in accordance with the stock take schedule and scope and included a roster for the systematic dismantling and cleaning of the refinery, following the process flow. A target population of maximum five fitters and five operators per area were identified, responsible for dismantling and cleaning plant equipment respectively. The sampling strategy was based on the identification and sampling of employees presumed to have the highest exposure risk. The Occupational Exposure Sampling Strategy Manual (OESSM) refers to this as the “maximum risk employees” (Liedel et al., 1977). The selection of the maximum risk employees was done with reasonable certainty since the employees sampled were working closest to the source of exposure. Sampling was conducted for the total duration of the task consisting of single sample measurements. Area…

Subjects/Keywords: Platinum-raffinadery; Nie-operasionele periode; Blootstellingsvlakke; Platinum; Platinumsout sensitisering; Platinum refinery; Non-operational period; Exposure levels; Platinum; Platinum salt sensitisation

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APA (6^th Edition):

Vos, A. (2011). Evaluation of exposure to airborne soluble platinum in a precious metal refinery during non–routine operations / Amelda Vos . (Thesis). North-West University. Retrieved from http://hdl.handle.net/10394/7601

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vos, Amelda. “Evaluation of exposure to airborne soluble platinum in a precious metal refinery during non–routine operations / Amelda Vos .” 2011. Thesis, North-West University. Accessed March 04, 2021. http://hdl.handle.net/10394/7601.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vos, Amelda. “Evaluation of exposure to airborne soluble platinum in a precious metal refinery during non–routine operations / Amelda Vos .” 2011. Web. 04 Mar 2021.

Vancouver:

Vos A. Evaluation of exposure to airborne soluble platinum in a precious metal refinery during non–routine operations / Amelda Vos . [Internet] [Thesis]. North-West University; 2011. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10394/7601.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vos A. Evaluation of exposure to airborne soluble platinum in a precious metal refinery during non–routine operations / Amelda Vos . [Thesis]. North-West University; 2011. Available from: http://hdl.handle.net/10394/7601

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Montana State University

17. Peterson, Eric Spencer. The synthesis, analysis, and characterization of a group of platinum clusters.

Degree: PhD, College of Letters & Science, 1987, Montana State University

URL: https://scholarworks.montana.edu/xmlui/handle/1/6587

Subjects/Keywords: Platinum compounds Composition.; Platinum.; Platinum alloys.

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APA (6^th Edition):

Peterson, E. S. (1987). The synthesis, analysis, and characterization of a group of platinum clusters. (Doctoral Dissertation). Montana State University. Retrieved from https://scholarworks.montana.edu/xmlui/handle/1/6587

Chicago Manual of Style (16^th Edition):

Peterson, Eric Spencer. “The synthesis, analysis, and characterization of a group of platinum clusters.” 1987. Doctoral Dissertation, Montana State University. Accessed March 04, 2021. https://scholarworks.montana.edu/xmlui/handle/1/6587.

MLA Handbook (7^th Edition):

Peterson, Eric Spencer. “The synthesis, analysis, and characterization of a group of platinum clusters.” 1987. Web. 04 Mar 2021.

Vancouver:

Peterson ES. The synthesis, analysis, and characterization of a group of platinum clusters. [Internet] [Doctoral dissertation]. Montana State University; 1987. [cited 2021 Mar 04]. Available from: https://scholarworks.montana.edu/xmlui/handle/1/6587.

Council of Science Editors:

Peterson ES. The synthesis, analysis, and characterization of a group of platinum clusters. [Doctoral Dissertation]. Montana State University; 1987. Available from: https://scholarworks.montana.edu/xmlui/handle/1/6587

NSYSU

18. Kung, Hsiang-Chao. Study the coordination of 5,5'-bi(2-chloropyrimidine-4-yl)-[2,2']bithiohpenbe with metal ion.

Degree: Master, Chemistry, 2001, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0911101-141113

none Advisors/Committee Members: none (chair), Tsu-Hsin Chang (committee member), none (chair), none (chair), none (chair).

Subjects/Keywords: platinum complex

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APA (6^th Edition):

Kung, H. (2001). Study the coordination of 5,5'-bi(2-chloropyrimidine-4-yl)-[2,2']bithiohpenbe with metal ion. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0911101-141113

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kung, Hsiang-Chao. “Study the coordination of 5,5'-bi(2-chloropyrimidine-4-yl)-[2,2']bithiohpenbe with metal ion.” 2001. Thesis, NSYSU. Accessed March 04, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0911101-141113.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kung, Hsiang-Chao. “Study the coordination of 5,5'-bi(2-chloropyrimidine-4-yl)-[2,2']bithiohpenbe with metal ion.” 2001. Web. 04 Mar 2021.

Vancouver:

Kung H. Study the coordination of 5,5'-bi(2-chloropyrimidine-4-yl)-[2,2']bithiohpenbe with metal ion. [Internet] [Thesis]. NSYSU; 2001. [cited 2021 Mar 04]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0911101-141113.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kung H. Study the coordination of 5,5'-bi(2-chloropyrimidine-4-yl)-[2,2']bithiohpenbe with metal ion. [Thesis]. NSYSU; 2001. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0911101-141113

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

19. Sola Quiroz, Carolina. Kinetic Model for a Platinum Diesel Oxidation Catalyst.

Degree: MS, Department of Chemical and Materials Engineering, 2011, University of Alberta

URL: https://era.library.ualberta.ca/files/q524jp28d

► Using data from artificial gas mixtures, global kinetic models for a platinum diesel oxidation catalyst are developed. The modelling of CO and C3H6 was inspired… (more)

Subjects/Keywords: Platinum; Modelling; Diesel; Voltz; Catalyst

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APA (6^th Edition):

Sola Quiroz, C. (2011). Kinetic Model for a Platinum Diesel Oxidation Catalyst. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/q524jp28d

Chicago Manual of Style (16^th Edition):

Sola Quiroz, Carolina. “Kinetic Model for a Platinum Diesel Oxidation Catalyst.” 2011. Masters Thesis, University of Alberta. Accessed March 04, 2021. https://era.library.ualberta.ca/files/q524jp28d.

MLA Handbook (7^th Edition):

Sola Quiroz, Carolina. “Kinetic Model for a Platinum Diesel Oxidation Catalyst.” 2011. Web. 04 Mar 2021.

Vancouver:

Sola Quiroz C. Kinetic Model for a Platinum Diesel Oxidation Catalyst. [Internet] [Masters thesis]. University of Alberta; 2011. [cited 2021 Mar 04]. Available from: https://era.library.ualberta.ca/files/q524jp28d.

Council of Science Editors:

Sola Quiroz C. Kinetic Model for a Platinum Diesel Oxidation Catalyst. [Masters Thesis]. University of Alberta; 2011. Available from: https://era.library.ualberta.ca/files/q524jp28d

Nelson Mandela Metropolitan University

20. Oosthuizen, Lukas Marthinus. New platinum coordination compounds : their synthesis, characterization and anticancer application.

Degree: Faculty of Science, 2009, Nelson Mandela Metropolitan University

URL: http://hdl.handle.net/10948/d1018795

► The aim of this thesis was to investigate the properties of novel platinum compounds with possible potential as anticancer agents, and to determine how their… (more)

▼ The aim of this thesis was to investigate the properties of novel platinum compounds with possible potential as anticancer agents, and to determine how their behaviour could lead to a better understanding of the chemistry involved. The final criteria were improvement of their anticancer behaviour. Since many questions are still unanswered as to the role of sulfur in anticancer action, studies were undertaken to synthesize novel platinum(II) complexes having non-leaving groups consisting of a combination of an aromatic nitrogen and thioetherial sulfur capable of forming a five membered ring upon coordination. The structural unit was 1-methyl-2-methylthioalkyl/aryl. Numerous complexes formed by these ligands each having chloro, bromo, iodo and oxalato leaving groups were then fully characterized. The results obtained by the various synthetic methods were compared and explained in terms of the chemistry involved. The role of the sulfur donor was indicated in both the halo- and oxalato-complexes and proved to be strongly influenced by the nature of the leaving groups. Their differences are reflected in their anticancer behaviour. The study was extended to mononitroplatinum(IV) complexes, in view of the kinetically stable platinum(IV) compounds and advantages related to this. A specific mononitroplatinum(IV) complex which proved to have good anticancer and STAT 3 properties could according to the literature not be synthesized successfully in a good yield and a high degree of purity. The results of extensive studies showed that the main problem centred around the simultaneous reactions in equilibrium during the synthesis. A number of these species formed as a result of side reactions could be identified and their close separation factors indicated chromatographically. The mechanism of these reactions and the unstable intermediate species involved could be rationalized and compared to analogues in the literature. All the complexes studied were characterized by spectral and thermal methods both in solution as well as the solid state. Their anticancer behaviour towards three anticancer cell lines (Hela, MCF 7, Ht 29) were determined and acted as a guide towards possible structural modifications for their improved capability. Three crystal structures of platinum(II) complexes were determined. The extent of the ionization of the platinum(II) complexes as well the redox potentials (Pt(II) / Pt(IV)) of the platinum(IV) complexes were particularly important factors pertaining to their anticancer action.

Subjects/Keywords: Platinum compounds; Antineoplastic agents

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APA (6^th Edition):

Oosthuizen, L. M. (2009). New platinum coordination compounds : their synthesis, characterization and anticancer application. (Thesis). Nelson Mandela Metropolitan University. Retrieved from http://hdl.handle.net/10948/d1018795

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Oosthuizen, Lukas Marthinus. “New platinum coordination compounds : their synthesis, characterization and anticancer application.” 2009. Thesis, Nelson Mandela Metropolitan University. Accessed March 04, 2021. http://hdl.handle.net/10948/d1018795.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Oosthuizen, Lukas Marthinus. “New platinum coordination compounds : their synthesis, characterization and anticancer application.” 2009. Web. 04 Mar 2021.

Vancouver:

Oosthuizen LM. New platinum coordination compounds : their synthesis, characterization and anticancer application. [Internet] [Thesis]. Nelson Mandela Metropolitan University; 2009. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10948/d1018795.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Oosthuizen LM. New platinum coordination compounds : their synthesis, characterization and anticancer application. [Thesis]. Nelson Mandela Metropolitan University; 2009. Available from: http://hdl.handle.net/10948/d1018795

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Nelson Mandela Metropolitan University

21. Louw, Talana. The separation of platinum and gold from an industrial feed solution.

Degree: Faculty of Science, 2008, Nelson Mandela Metropolitan University

URL: http://hdl.handle.net/10948/731

► In this thesis, the aim was to develop resins which are platinum and gold specific to be utilized for the early removal of these metals… (more)

▼ In this thesis, the aim was to develop resins which are platinum and gold specific to be utilized for the early removal of these metals from the industrial feed. Efforts were therefore directed towards the synthesis of silica based resins with active centra which were designed for platinum and gold specificity respectively. The large chlorometallate ions in the feed stream were characterized in terms of physical parameters relevant to phase distribution namely distortability (RD), charge density, softness (σ) etc. Matching cations for each of the types were investigated. In order to attempt the design of platinum specific resins different structural amines were used to aminate the silicone precursor and subsequently to fix these onto the silica framework. Two different solvents i.e. alcohol and dmf were used for this process, resulting in two sets of resins with different properties. For gold specific resins, various polyethers were attached to a different type of silicone precursor, which was attached to the silica framework. The design was based on previous experience with these ions with reference to their behaviour towards different types of cations. The platinum species PtCl6 2- and PtCl4 2-, the gold species AuCl4 -, as well as the most important contaminants in the feed stream were typified bearing in mind size, charge, charge density and distortability. Different types of cationic centra having differences in charge density, stereochemical crowding and extent of hydrophobicity were synthesized and tested both as solvent extractants (where possible) and silica based resins. The results indicated that partly screened secondary ammonium cationic resin species, which could be regarded as “intermediate”, proved to be satisfactory both in their high percentage extraction for PtCl4 2- and rejection of contaminants like chlororhodates, chloroiridates(III) and FeCl4 -. It was, however, necessary to work at a redox potential where iridium(IV) in the form of IrCl6 2- is absent. Various 2-aminoalkane resins were prepared with variation in the length of alkane group and synthesized in the two different solvents. The latter resulted in two sets of resins with different compactness also having significantly different properties with reference to platinum specificity, HCl effect and stripping potential. The 2- aminobutane and 2-aminoheptane resins both proved to be very satisfactory platinum specific resins with respect to selectivity, platinum capacity and stripping potential. The various physical parameters could be utilized to accommodate the chemical behaviour. To obtain gold specific resins, experiments were performed with resins having oxygen-donor atoms which can readily be protonated to form onium type cations for example amides and ether oxygen atoms. In the case of the latter, various polyethers with a different number of ether groups (polyether groups linked by ethylene and propylene groups) and variations of hydrophobicity (by substitution) have also been studied. Linked to the polyether groups were alkane and…

Subjects/Keywords: Platinum – Separation; Gold; Separation – Technology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Louw, T. (2008). The separation of platinum and gold from an industrial feed solution. (Thesis). Nelson Mandela Metropolitan University. Retrieved from http://hdl.handle.net/10948/731

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Louw, Talana. “The separation of platinum and gold from an industrial feed solution.” 2008. Thesis, Nelson Mandela Metropolitan University. Accessed March 04, 2021. http://hdl.handle.net/10948/731.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Louw, Talana. “The separation of platinum and gold from an industrial feed solution.” 2008. Web. 04 Mar 2021.

Vancouver:

Louw T. The separation of platinum and gold from an industrial feed solution. [Internet] [Thesis]. Nelson Mandela Metropolitan University; 2008. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10948/731.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Louw T. The separation of platinum and gold from an industrial feed solution. [Thesis]. Nelson Mandela Metropolitan University; 2008. Available from: http://hdl.handle.net/10948/731

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. Nadgeri, Jayprakash M. Studies on mono bimetallic and nano catalysts of nickel palladium and platinum metals and their applications in selective hydrogenation of acetylenic compounds and nitroaromatics of industrial relevance.

Degree: Chemical Engineering, 2011, University of Pune

URL: http://shodhganga.inflibnet.ac.in/handle/10603/3233

►

Catalysis has been playing a major role for last few decades due to its wide range applications in various fields such as fuel cell as… (more)

▼

Catalysis has been playing a major role for last few decades due to its wide range applications in various fields such as fuel cell as renewable source of energy, abatement of air pollution, waste water treatment, environmental protection by developing green processes. In particular, due to increasing awareness of environmental issues, chemical industries look for the cleaner, safer, environmentally acceptable alternative and sustainable processes. Chemical processes should have minimum waste generation, improved product quality and cost effectiveness. Traditionally, for manufacturing fine chemicals the synthetic organic chemists used the classical ‘stoichiometric’ routes, which generate large amount of organic or inorganic wastes in the range of 1-100 kg byproduct formed per kg of product, which gives serious impact on environment and hence on human life. Some of the well known examples of such processes are oxidations with permanganate and chromium compounds, reductions with metal acids and metal hydrides, halogenations, alkylation, nitration etc. These processes are now being replaced by catalytic routes and among these processes, catalytic hydrogenation reactions of various organic functional groups is one of the core technologies widely used in chemical industries. Although hydrogenation is supposed to be a well developed subjected area, there is a great deal that can be still done for fundamental understanding particularly, in designing new catalysts and routes for selective hydrogenation reactions of industrial relevance [1]. For this purpose, we undertook a detailed study on the preparation and characterization of mono-, bimetallic and nanocatalysts using nickel, palladium and platinum metals. These catalysts were evaluated for their activities for the selective hydrogenation of 2-butyne- 1,4-diol to 2-butene-1,4-diol and butane-1,4-diols, phenylacetylene to styrene, nitrobenzene to p-aminophenol, m-chloronitrobenzene to m chloroaniline.

Conclusion p. 231-233, List of publications p. 234-236

Advisors/Committee Members: Rode, Chandrashekhar V.

Subjects/Keywords: Acetylenic compunds; Platinum metals

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APA (6^th Edition):

Nadgeri, J. M. (2011). Studies on mono bimetallic and nano catalysts of nickel palladium and platinum metals and their applications in selective hydrogenation of acetylenic compounds and nitroaromatics of industrial relevance. (Thesis). University of Pune. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/3233

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nadgeri, Jayprakash M. “Studies on mono bimetallic and nano catalysts of nickel palladium and platinum metals and their applications in selective hydrogenation of acetylenic compounds and nitroaromatics of industrial relevance.” 2011. Thesis, University of Pune. Accessed March 04, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/3233.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nadgeri, Jayprakash M. “Studies on mono bimetallic and nano catalysts of nickel palladium and platinum metals and their applications in selective hydrogenation of acetylenic compounds and nitroaromatics of industrial relevance.” 2011. Web. 04 Mar 2021.

Vancouver:

Nadgeri JM. Studies on mono bimetallic and nano catalysts of nickel palladium and platinum metals and their applications in selective hydrogenation of acetylenic compounds and nitroaromatics of industrial relevance. [Internet] [Thesis]. University of Pune; 2011. [cited 2021 Mar 04]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/3233.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nadgeri JM. Studies on mono bimetallic and nano catalysts of nickel palladium and platinum metals and their applications in selective hydrogenation of acetylenic compounds and nitroaromatics of industrial relevance. [Thesis]. University of Pune; 2011. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/3233

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rhodes University

23. Riddin, Tamsyn Louise. Investigating the enzymatic mechanism of platinum nanoparticle synthesis in sulfate-reducing bacteria.

Degree: MS, Faculty of Science, Biochemistry, Microbiology and Biotechnology, 2009, Rhodes University

URL: http://hdl.handle.net/10962/d1004024

► Efforts to discover an efficient yet environmentally friendly mode of metal nanoparticle (NP) synthesis are increasing rapidly. A ‘green’ route that avoids the high costs,… (more)

▼ Efforts to discover an efficient yet environmentally friendly mode of metal nanoparticle (NP) synthesis are increasing rapidly. A ‘green’ route that avoids the high costs, toxic wastes and complicated protocols associated with chemical synthesis methods is therefore highly sought after. A biologically based protocol will provide the possibility of gaining control over the mechanism merely by manipulating the experimental conditions of the system. Given that the properties of nanoparticles are highly dependant on the morphology of the particles themselves, this mechanistic control will provide significant industrial advantages with regards to tailoring specific properties of the nanoparticles produced. The key objectives of this study were to: a) determine whether a consortium of sulfate-reducing bacteria was capable of platinum nanoparticle synthesis, b) elucidate the bioreductive, enzymatic mechanism responsible, and c) attempt to control the morphologies of the particles produced. A consortium of sulfate-reducing bacteria (SRB), isolated from sewage sludge, was used in these investigations due to the advantages a consortium provides in comparison to pure cultures. The syntrophic relationships established within the constituent species not only prevent the growth of contaminant microbes, but increases the oxygen-tolerance of the system as a whole. The sulfate-reducing consortium was shown to possess an aerobic mechanism for Pt(IV) reduction which, though different from the anaerobic bioreductive mechanism previously identified in literature, did not require an exogenous electron donor. It was demonstrated that the Pt(IV) ion becomes reduced to Pt(0) via a two-cycle mechanism involving Pt(II) as the intermediate. Further investigation elucidated the reduction of Pt(IV) to Pt(II) to be dependant on a novel Pt(IV) reductase which becomes upregulated in the presence of Cu(II), while the reduction of Pt(II) to Pt(0) occurred by means of a periplasmic hydrogenase. To our knowledge, this is the first time a coupled mechanism for Pt(IV) reduction by micro-organisms has been proposed. A cell-free, crude protein solution from the consortium produced both geometric and irregular platinum nanoparticles. The wavelength of 334 nm was chosen as a nonquantitative indicator of Pt(0) nanoparticle formation over time. The optimum conditions for nanoparticle synthesis were pH 9.0, 65 ˚C and 0.75 mM Pt(IV) as H2PtCl6 salt. In the absence of a buffer a Pt(IV) concentration > 1 mM resulted in the precipitation of protein-nanoparticle bioconjugates, due to unfavourable acidic conditions. This demonstrated that the nanoparticles were binding to and becoming stabilised by general protein in the cell-free solution. Upon addition of a sodium-bicarbonate buffer, a general increase in Pt(IV) reduction to Pt(II) was observed. The addition of the buffer also resulted in an unexplained change in particle morphology and for this reason was not used in subsequent investigations. Polyvinylpyrrolidone (PVP) was shown to compromise the reduction rate of…

Subjects/Keywords: Platinum; Nanoparticles; Sulfate-reducing bacteria

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APA (6^th Edition):

Riddin, T. L. (2009). Investigating the enzymatic mechanism of platinum nanoparticle synthesis in sulfate-reducing bacteria. (Masters Thesis). Rhodes University. Retrieved from http://hdl.handle.net/10962/d1004024

Chicago Manual of Style (16^th Edition):

Riddin, Tamsyn Louise. “Investigating the enzymatic mechanism of platinum nanoparticle synthesis in sulfate-reducing bacteria.” 2009. Masters Thesis, Rhodes University. Accessed March 04, 2021. http://hdl.handle.net/10962/d1004024.

MLA Handbook (7^th Edition):

Riddin, Tamsyn Louise. “Investigating the enzymatic mechanism of platinum nanoparticle synthesis in sulfate-reducing bacteria.” 2009. Web. 04 Mar 2021.

Vancouver:

Riddin TL. Investigating the enzymatic mechanism of platinum nanoparticle synthesis in sulfate-reducing bacteria. [Internet] [Masters thesis]. Rhodes University; 2009. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10962/d1004024.

Council of Science Editors:

Riddin TL. Investigating the enzymatic mechanism of platinum nanoparticle synthesis in sulfate-reducing bacteria. [Masters Thesis]. Rhodes University; 2009. Available from: http://hdl.handle.net/10962/d1004024

Rhodes University

24. Datt, Michael Steven. Synthesis and characterisation of novel platinum (II) complexes potential chemotherapeutic drugs.

Degree: PhD, Faculty of Science, Chemistry, 2001, Rhodes University

URL: http://hdl.handle.net/10962/d1005031

► The present study involves the preparation of novel mixed-ligand platinum(II) complexes in the hope of expanding the range of platinum(II) complexes that exhibit anticancer activity… (more)

▼ The present study involves the preparation of novel mixed-ligand platinum(II) complexes in the hope of expanding the range of platinum(II) complexes that exhibit anticancer activity and which are less toxic and have a broader spectrum of activity than cisplatin and its analogues. To this end, N-(3-R-benzoyl)-N’,N’-diethylthiourea, N-(3-R-benzoyl)-N’-morpholinothiourea, N-(3-Rbenzoyl)-N’,N’-di(2-hydroxyethyl)thiourea (R = NO2, Cl, H, CH3, OCH3), N,N-diethyl-N’-menthyloxycarbonylthiourea and N-menthyloxycarbonyl-N’-morpholinothiourea ligands, and their corresponding mixed-ligand platinum(II) complexes of the type [PtCl(L)(RR’SO)], were synthesised and characterised by elemental analyses, IR, 1H and 195Pt NMR spectroscopy and, in some cases, X-ray crystallography. Dimethylsulfoxide complexes were prepared using all the ligands, while complexes containing unsymmetrically substituted sulfoxides were prepared using the N-benzoyl-N’,N’-diethylthiourea and ,N-diethyl-’-(-)-(3R)-menthyloxycarbonylthiourea ligands only. The molecular structures of cis-(S,S)-[PtCl(DMSO)(L)] (where L = N-benzoyl-N’,N’-diethylthioureato, N-(+)-(3S)-menthyloxycarbonyl-N’-morpholinothioureato), cis-(S,S)-[Pt(N-benzoyl-N’,N’-diethylthioureato)Cl(MPSO)] and cis-[Pt(N-benzoyl-N’,N’-diethylthioureato)2] were determined by X-ray crystallography. The X-ray crystal structure of N,N-diethyl-N’- (-)-(3R)-menthyloxycarbonylthiourea was also determined. The spectroscopic and crystallographic data are consistent with complexes containing a (S,O)-chelated ligand and a sulfur-bonded sulfoxide ligand. However, the 1H and 195Pt NMR studies showed that the alkoxycarbonylthioureato complexes exist as geometric isomers with the sulfoxide coordinated either in a cis-(S,S) or trans-(S,S) arrangement with respect to the sulfur donor atom of the chelated ligand, whereas the acylthioureato complexes yielded only cis-(S,S)-[PtCl(L)(RR’SO)] complexes. The difference in the coordination chemistry of the acylthiourea and alkoxycarbonylthiourea ligands was examined further by treatment of the [PtCl(DMSO)(L)] complexes, where L = Nbenzoyl-N’,N’-diethylthioureato, N-benzoyl-N’-morpholinothioureato, N,N-diethyl-N’-(-)-(3R)- menthyloxycarbonylthioureato and N-(+)-(3S)-menthyloxycarbonyl-N’-morpholinothioureato, with PPh3 to give the corresponding [PtCl(L)(PPh3)] and [Pt(L)(PPh3)2]+ complexes. 31P NMR studies of these complexes reveal that the alkoxycarbonylthioureato ligands bind less strongly than the acylthioureato ligands, which is consistent with the crystallographic studies. The morpholine derivatives of the acylthioureato and alkoxycarbonylthioureato ligand systems also appear to bind less tightly than the diethyl derivatives. The weaker binding properties of the alkoxycarbonylthioureato ligands might be a possible explanation for the observed geometric isomerisation of these complexes, with the mechanism of isomerisation involving a chelate ringiv opening step. Furthermore, crystallographic and 31P NMR studies suggest that the acylthioureato carbonyl oxygen donor atom is… Advisors/Committee Members: Sacht, Cheryl.

Subjects/Keywords: Chemotherapy; Platinum

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Datt, M. S. (2001). Synthesis and characterisation of novel platinum (II) complexes potential chemotherapeutic drugs. (Doctoral Dissertation). Rhodes University. Retrieved from http://hdl.handle.net/10962/d1005031

Chicago Manual of Style (16^th Edition):

Datt, Michael Steven. “Synthesis and characterisation of novel platinum (II) complexes potential chemotherapeutic drugs.” 2001. Doctoral Dissertation, Rhodes University. Accessed March 04, 2021. http://hdl.handle.net/10962/d1005031.

MLA Handbook (7^th Edition):

Datt, Michael Steven. “Synthesis and characterisation of novel platinum (II) complexes potential chemotherapeutic drugs.” 2001. Web. 04 Mar 2021.

Vancouver:

Datt MS. Synthesis and characterisation of novel platinum (II) complexes potential chemotherapeutic drugs. [Internet] [Doctoral dissertation]. Rhodes University; 2001. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10962/d1005031.

Council of Science Editors:

Datt MS. Synthesis and characterisation of novel platinum (II) complexes potential chemotherapeutic drugs. [Doctoral Dissertation]. Rhodes University; 2001. Available from: http://hdl.handle.net/10962/d1005031

Penn State University

25. Tremper, Amber Leigh. TIME DEPENDENT DEFORMATION OF THIN FILM PLATINUM DURING NANOINDENTATION TESTING .

Degree: 2009, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/9144

► Previous nanoindentation studies of thin film platinum have reported elastic moduli values that are approximately 10 to 25 percent lower than the expected polycrystalline aggregate… (more)

▼ Previous nanoindentation studies of thin film platinum have reported elastic moduli values that are approximately 10 to 25 percent lower than the expected polycrystalline aggregate values. However, no explanation of these low moduli values was given. This study attempts to explore the cause of the low moduli values and further evaluate thin film platinum properties. Instrument artifact, spatial variation, and time-dependency were examined as possible explanation of the low moduli values. Instrument artifacts such as pile-up, machine compliance, residual stresses, surface roughness, and delamination and/or microcracking were eliminated as potential sources of the low moduli values. After correction for both pile-up and machine compliance, the platinum film in this study was found to have a reduced modulus approximately 10 percent lower than that expected from anisotropic elasticity and indentation theories. The film did show spatial variation in mechanical properties, with one region having a modulus that was approximately five percent higher than the theoretical prediction. Additionally, the two different regions showed differing sensitivity to loading and unloading rate during indentation testing. These two combined facts suggest that the material has a spatial variation of mechanical properties, which could be caused by surface chemistry or morphology, localized processing effects, or discohered platinum from the silicon substrate. In the low moduli regions, the film exhibited a time dependent behavior, likely due to anelasticity, or reversible linear viscoelasticity. The loading rate dependency of the load-displacement curves and the independency of the residual indentation depth support this theory. Ultimately, the reported low moduli values previously reported in the literature and in this study are likely due to spatial variation and an anelastic response of thin film platinum, and are not caused by instrument artifact. During the testing of thin film platinum, it was discovered that several indentation tests showed anomalous behavior at very slow loading rates that could not be explained in conjunction with the other, normal results. The abnormal tests had bulging loading and unloading curves, causing the material to appear inconsistently stiff during loading and soft during unloading. When the system displacement drift was examined, it was found to be an important factor in the quality of slow loading rate, long duration test data. Drift experiments showed that the drift rate during a test is non-constant, uncorrectable, and may cause large uncertainties and errors in the values derived from long duration tests. The accumulated drift as a percentage of maximum indentation depth proved to be a good criterion for identifying unreliable data. When the accumulated drift percentage was larger than 100 percent, the elastic moduli values were non-physical due to gross abnormalities in the force-displacement curves. Therefore, tests with accumulated drift percentages larger than 100 percent should be… Advisors/Committee Members: Dr Christopher Muhlstein, Thesis Advisor/Co-Advisor, Christopher Muhlstein, Thesis Advisor/Co-Advisor, Lawrence Friedman, Thesis Advisor/Co-Advisor.

Subjects/Keywords: nanoindentation; platinum

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APA (6^th Edition):

Tremper, A. L. (2009). TIME DEPENDENT DEFORMATION OF THIN FILM PLATINUM DURING NANOINDENTATION TESTING . (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/9144

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tremper, Amber Leigh. “TIME DEPENDENT DEFORMATION OF THIN FILM PLATINUM DURING NANOINDENTATION TESTING .” 2009. Thesis, Penn State University. Accessed March 04, 2021. https://submit-etda.libraries.psu.edu/catalog/9144.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tremper, Amber Leigh. “TIME DEPENDENT DEFORMATION OF THIN FILM PLATINUM DURING NANOINDENTATION TESTING .” 2009. Web. 04 Mar 2021.

Vancouver:

Tremper AL. TIME DEPENDENT DEFORMATION OF THIN FILM PLATINUM DURING NANOINDENTATION TESTING . [Internet] [Thesis]. Penn State University; 2009. [cited 2021 Mar 04]. Available from: https://submit-etda.libraries.psu.edu/catalog/9144.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tremper AL. TIME DEPENDENT DEFORMATION OF THIN FILM PLATINUM DURING NANOINDENTATION TESTING . [Thesis]. Penn State University; 2009. Available from: https://submit-etda.libraries.psu.edu/catalog/9144

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Queens University

26. Furuya, Yoshihisa. Comprehensive Study of the Electrochemical Behavior of Polycrystalline Platinum Electrodes in Aqueous Solutions of Trifluoromethanesulfonic Acid .

Degree: Chemistry, 2014, Queens University

URL: http://hdl.handle.net/1974/12635

► Trifluoromethanesulfonic acid (CF3SO3H) is the smallest fluorinated sulfonic acid and serves as a model imitating the Nafion® ionomer of catalyst layers of polymer electrolyte membrane… (more)

▼ Trifluoromethanesulfonic acid (CF3SO3H) is the smallest fluorinated sulfonic acid and serves as a model imitating the Nafion® ionomer of catalyst layers of polymer electrolyte membrane fuel cells (PEMFCs). The difference in the electrochemical behavior of Pt in CF3SO3H, as compared to H2SO4 or HClO4, originates from the different anion nature. Because PEMFCs operate in the potential range in which electrochemical reactions involving O and H occur, the thesis focuses on: (i) Pt electro-oxidation; (ii) H electro-adsorption; and (iii) electrochemical and chemical Pt dissolution. Platinum electro-oxidation in 0.1 M CF3SO3H is studied at various polarization potentials (Ep), polarization times (tp) and temperatures (T). The reaction mechanism is revised and expanded by taking into account possible interactions of cations, anions and water molecules with Pt. A modified kinetic equation for the interfacial place exchange is proposed. The application of the interfacial place exchange and the metal cation escape mechanisms results in the determination of the Pt–O surface dipole moment, as well as the potential drop (Vox) and electric field (Eox) within the oxide. The platinum-anion interactions indirectly affect the surface electro-oxidation kinetics. The under-potential deposition of H (UPD H) on Pt in CF3SO3H is investigated over a broad T range using cyclic voltammetry. The general electrochemical adsorption isotherm is used to determine standard Gibbs energy, entropy, and enthalpy of electro-adsorption, and energy of the Pt‒HUPD surface bond. The lateral interactions between HUPD adatoms are repulsive. Platinum electro-dissolution in 0.1 and 0.5 M CF3SO3H, H2SO4, and HClO4 solutions is studied using potential cycling and inductively coupled plasma mass spectrometry. The results demonstrate that the anion nature has no or negligible impact on Pt electro-dissolution; however, pH significantly affects the process and the higher the pH value the greater the electro-dissolution of Pt. An analysis of potential versus pH diagrams (Pourbaix diagrams) for acid solutions of different concentrations demonstrates that dissolved Pt (present as Pt2+ and Pt4+) can form through anodic dissolution of metallic Pt, as well as through anodic electrochemical and chemical dissolution of PtO.

Subjects/Keywords: Platinum ; Trifluoromethanesulfonic acid ; Fuel cell

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Furuya, Y. (2014). Comprehensive Study of the Electrochemical Behavior of Polycrystalline Platinum Electrodes in Aqueous Solutions of Trifluoromethanesulfonic Acid . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/12635

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Furuya, Yoshihisa. “Comprehensive Study of the Electrochemical Behavior of Polycrystalline Platinum Electrodes in Aqueous Solutions of Trifluoromethanesulfonic Acid .” 2014. Thesis, Queens University. Accessed March 04, 2021. http://hdl.handle.net/1974/12635.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Furuya, Yoshihisa. “Comprehensive Study of the Electrochemical Behavior of Polycrystalline Platinum Electrodes in Aqueous Solutions of Trifluoromethanesulfonic Acid .” 2014. Web. 04 Mar 2021.

Vancouver:

Furuya Y. Comprehensive Study of the Electrochemical Behavior of Polycrystalline Platinum Electrodes in Aqueous Solutions of Trifluoromethanesulfonic Acid . [Internet] [Thesis]. Queens University; 2014. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1974/12635.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Furuya Y. Comprehensive Study of the Electrochemical Behavior of Polycrystalline Platinum Electrodes in Aqueous Solutions of Trifluoromethanesulfonic Acid . [Thesis]. Queens University; 2014. Available from: http://hdl.handle.net/1974/12635

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

North-West University

27. Raats, Jasper-Johan. Shareholder value optimisation in the platinum industry during recessionary times / Jasper-Johan Raats .

Degree: 2010, North-West University

URL: http://hdl.handle.net/10394/8299

► The recession of 2008/09 was the worst decline of global markets since the Great Depression in the 1930's. Some international markets lost 30 - 50%… (more)

▼ The recession of 2008/09 was the worst decline of global markets since the Great Depression in the 1930's. Some international markets lost 30 - 50% of its value in the period July to October 2008. The main reason for this dramatic drop in investor demand was the sub prime crisis in the USA where growth was fuelled by providing loans to house owners who could not afford the mortgage payments. Platinum, which is the biggest mining sector in South Africa both in terms of revenue and employment, was not spared this sudden decrease in demand. Platinum market price lost more than 50% of its value, free-falling from a level of over 2000/oz to below 1 000/oz in three months. A recession poses a massive challenge to the management teams of companies. Their main task of ensuring shareholder value growth comes under enormous pressure from macro-economic factors outside of their control. Strategic objectives based on high growth and demand scenarios have to be adapted to a low demand and negative growth environment. This study embarks on a journey to determine what strategies the different management teams of the five top South African platinum mining companies implemented and how successful they were in optimising shareholder value during the recession period. The impact of risk and return on investor demand were discussed on a theoretical level and tested on a practical level by evaluating the performances of individual companies and finding correlations between company performance and shareholder value optimisation. Companies who performed well by maintaining good profit margins, maintaining dividend payouts, managing risks well and continuing to build a good platform for future profit growth performed the best in optimising shareholder value during the recession period. Recommendations are made based on theoretical and practical best practices for how to optimise shareholder value during future recessionary times. Opportunities for companies in the platinum mining industry for the next 3 - 5 years are also evaluated and summarized.

Subjects/Keywords: Platinum; Recession; Shareholder value

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APA (6^th Edition):

Raats, J. (2010). Shareholder value optimisation in the platinum industry during recessionary times / Jasper-Johan Raats . (Thesis). North-West University. Retrieved from http://hdl.handle.net/10394/8299

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Raats, Jasper-Johan. “Shareholder value optimisation in the platinum industry during recessionary times / Jasper-Johan Raats .” 2010. Thesis, North-West University. Accessed March 04, 2021. http://hdl.handle.net/10394/8299.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Raats, Jasper-Johan. “Shareholder value optimisation in the platinum industry during recessionary times / Jasper-Johan Raats .” 2010. Web. 04 Mar 2021.

Vancouver:

Raats J. Shareholder value optimisation in the platinum industry during recessionary times / Jasper-Johan Raats . [Internet] [Thesis]. North-West University; 2010. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10394/8299.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Raats J. Shareholder value optimisation in the platinum industry during recessionary times / Jasper-Johan Raats . [Thesis]. North-West University; 2010. Available from: http://hdl.handle.net/10394/8299

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Hong Kong University of Science and Technology

28. Wong, Chi Cheong. Fabrication and characterizations of metallic nanostructured materials.

Degree: 2011, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-7378 ; https://doi.org/10.14711/thesis-b1154905 ; http://repository.ust.hk/ir/bitstream/1783.1-7378/1/th_redirect.html

► In this research, effective infiltration and deposition of metals into mesopores are achieved by supercritical fluid deposition (SFD) and modified chemical vapour deposition (CVD). A… (more)

Subjects/Keywords: Nanostructured materials ; Metallic composites ; Platinum

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APA (6^th Edition):

Wong, C. C. (2011). Fabrication and characterizations of metallic nanostructured materials. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-7378 ; https://doi.org/10.14711/thesis-b1154905 ; http://repository.ust.hk/ir/bitstream/1783.1-7378/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wong, Chi Cheong. “Fabrication and characterizations of metallic nanostructured materials.” 2011. Thesis, Hong Kong University of Science and Technology. Accessed March 04, 2021. http://repository.ust.hk/ir/Record/1783.1-7378 ; https://doi.org/10.14711/thesis-b1154905 ; http://repository.ust.hk/ir/bitstream/1783.1-7378/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wong, Chi Cheong. “Fabrication and characterizations of metallic nanostructured materials.” 2011. Web. 04 Mar 2021.

Vancouver:

Wong CC. Fabrication and characterizations of metallic nanostructured materials. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2011. [cited 2021 Mar 04]. Available from: http://repository.ust.hk/ir/Record/1783.1-7378 ; https://doi.org/10.14711/thesis-b1154905 ; http://repository.ust.hk/ir/bitstream/1783.1-7378/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wong CC. Fabrication and characterizations of metallic nanostructured materials. [Thesis]. Hong Kong University of Science and Technology; 2011. Available from: http://repository.ust.hk/ir/Record/1783.1-7378 ; https://doi.org/10.14711/thesis-b1154905 ; http://repository.ust.hk/ir/bitstream/1783.1-7378/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oregon

29. Plakos, Kory. Platinum-seq: High-throughput mapping of small-molecule platinum adducts on cellular RNA.

Degree: PhD, Department of Chemistry and Biochemistry, 2017, University of Oregon

URL: http://hdl.handle.net/1794/22269

► Methods to map small-molecule interactions with cellular RNAs are important for understanding endogenous activation, such as in riboswitches, as well as the potential for exogenous… (more)

▼ Methods to map small-molecule interactions with cellular RNAs are important for understanding endogenous activation, such as in riboswitches, as well as the potential for exogenous compounds to target RNA. Cisplatin is one of the most widely used of the platinum anticancer drugs that are prescribed in approximately 40-50% of all chemotherapy treatments (Dyson and Sava, 2006; Harper et al., 2010). Despite nearly 40 years of experience with this class of drugs, we still lack a comprehensive understanding of the targets of Pt compounds and their effects on cells. Pt(II) compounds are well-known DNA and RNA crosslinking agents, but the latter area is under-studied. In order to better understand the impacts of cisplatin and other platinum(II)-derived small molecules on cellular RNA, we have developed a technique we call “Platinum-seq,” which couples reverse transcription mapping of platinated RNAs to high-throughput sequencing. Chapter 1 is a study of cisplatin and a novel click-functionalized platinum compound (2-ADAP Pt) binding to the HDV ribozyme, a small catalytic RNA. Chapter 2 moves our platinum mapping approaches from low-throughput, sequencing gel based methods into next-generation sequencing for high-throughput analysis of all platinum sites in cellular RNA, a method we have named “Platinum-seq.” Chapter 3 is a study of differential gene expression of Saccharomyces cerevisiae treated with cisplatin and a second novel platinum(II) compound (azaplatin), using data acquired from the work in Chapter 2. Chapter 4 describes recent efforts to implement pre-enrichment of sequencing targets using click chemistry followed by DNA hybridization, in order to enrich for platinated fragments before sequencing library construction. Together, this work represents a significant step forward in advancing analysis of Pt(II) binding to cellular RNA, a potentially important target for this widely used class of anticancer compounds. Methods developed here are broadly applicable to genome-wide identification of platinum accumulation on DNA as well, which has not been pursued despite the extensive use of these compounds. Advisors/Committee Members: Hawley, Diane (advisor).

Subjects/Keywords: Cisplatin; Click; Platinum; RNA; Sequencing

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Plakos, K. (2017). Platinum-seq: High-throughput mapping of small-molecule platinum adducts on cellular RNA. (Doctoral Dissertation). University of Oregon. Retrieved from http://hdl.handle.net/1794/22269

Chicago Manual of Style (16^th Edition):

Plakos, Kory. “Platinum-seq: High-throughput mapping of small-molecule platinum adducts on cellular RNA.” 2017. Doctoral Dissertation, University of Oregon. Accessed March 04, 2021. http://hdl.handle.net/1794/22269.

MLA Handbook (7^th Edition):

Plakos, Kory. “Platinum-seq: High-throughput mapping of small-molecule platinum adducts on cellular RNA.” 2017. Web. 04 Mar 2021.

Vancouver:

Plakos K. Platinum-seq: High-throughput mapping of small-molecule platinum adducts on cellular RNA. [Internet] [Doctoral dissertation]. University of Oregon; 2017. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1794/22269.

Council of Science Editors:

Plakos K. Platinum-seq: High-throughput mapping of small-molecule platinum adducts on cellular RNA. [Doctoral Dissertation]. University of Oregon; 2017. Available from: http://hdl.handle.net/1794/22269

University of Oregon

30. Moghaddam, Alan. A Study of the Behavior and Localization of PT(II) Azide and Alkyne-Modified Derivatives in Cells Using Bioorthogonal Chemistry and Fluorescence Microscopy.

Degree: PhD, Department of Chemistry and Biochemistry, 2016, University of Oregon

URL: http://hdl.handle.net/1794/20727

► Despite their ubiquitous use, Pt(II) anti-cancer drugs still suffer from many issues such as off-drug target effects, renal and nephrotoxicity as well as acquired and… (more)

▼ Despite their ubiquitous use, Pt(II) anti-cancer drugs still suffer from many issues such as off-drug target effects, renal and nephrotoxicity as well as acquired and intrinsic drug resistance. To obtain a better understanding of how to mitigate these deleterious effects can be mitigated we first must know all the targets of these drugs. Highlighted in this dissertation is previous work performed by groups exploring the localization of Pt in cells using fluorescence microscopy. While Pt drugs such as cisplatin contain no native fluorescence, a great deal of work has been done to covalently modify complexes with fluorescent tags. From studies using this technique, it been reported that Pt can target a number of compartments within the cell ranging from the nucleus to the cytoplasm. With each different derivative being observed in varied cell lines it becomes difficult to deconvolute a universal pattern to where Pt localizes, furthermore, the connected fluorophore could also bias Pt localization. To add general functionality and eliminate the bias of a pre-tethered fluorophore our lab has developed a number of different azide and alkyne-modified complexes that append a “reactive handle” to Pt compounds. This modification allows for use of the bioorthogonal azide-alkyne click reaction we are able to observe Pt localization after treatment. The focus of this work includes method development to conjugate a fluorophore to our Pt complexes in vitro and in cell cultures. We examined a number of different cell lines and observed frequent localization in the nucleolus of the cell. Also in this work is the development of methods to append multiple fluorophores to each Pt site to increase our ability to visualize these complexes in cells. Finally, we have also constructed a new Pt-azide that exhibits slower exchange kinetics due to a chelating exchangeable group. The use of this new complex will enable studies to determine whether changing the leaving group results in differential localization of Pt drugs in cells. Advisors/Committee Members: DeRose, Victoria (advisor).

Subjects/Keywords: Alkyne; Azide; Cisplatin; Click; Platinum

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Moghaddam, A. (2016). A Study of the Behavior and Localization of PT(II) Azide and Alkyne-Modified Derivatives in Cells Using Bioorthogonal Chemistry and Fluorescence Microscopy. (Doctoral Dissertation). University of Oregon. Retrieved from http://hdl.handle.net/1794/20727

Chicago Manual of Style (16^th Edition):

Moghaddam, Alan. “A Study of the Behavior and Localization of PT(II) Azide and Alkyne-Modified Derivatives in Cells Using Bioorthogonal Chemistry and Fluorescence Microscopy.” 2016. Doctoral Dissertation, University of Oregon. Accessed March 04, 2021. http://hdl.handle.net/1794/20727.

MLA Handbook (7^th Edition):

Moghaddam, Alan. “A Study of the Behavior and Localization of PT(II) Azide and Alkyne-Modified Derivatives in Cells Using Bioorthogonal Chemistry and Fluorescence Microscopy.” 2016. Web. 04 Mar 2021.

Vancouver:

Moghaddam A. A Study of the Behavior and Localization of PT(II) Azide and Alkyne-Modified Derivatives in Cells Using Bioorthogonal Chemistry and Fluorescence Microscopy. [Internet] [Doctoral dissertation]. University of Oregon; 2016. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1794/20727.

Council of Science Editors:

Moghaddam A. A Study of the Behavior and Localization of PT(II) Azide and Alkyne-Modified Derivatives in Cells Using Bioorthogonal Chemistry and Fluorescence Microscopy. [Doctoral Dissertation]. University of Oregon; 2016. Available from: http://hdl.handle.net/1794/20727

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Open Access Theses and Dissertations