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You searched for subject:(Pillar Arrays). Showing records 1 – 2 of 2 total matches.

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1. Taylor, Lisa Christine. The fabrication and integration of pillar array channels for chip based separations and analysis.

Degree: 2012, University of Tennessee – Knoxville

The fundamental motivations for scaling existing technological platforms down to lab on chip dimensions are applicable in nearly all scientific disciplines. These motivations include decreasing waste, improving throughput, and decreasing time consumption. Analytical tools, such as chromatographic separation devices, can additionally benefit from system miniaturization by utilizing wafer-level fabrication technology, allowing for the rational design and precise control of variables which ultimately affect separation performance. With the use of microfabrication techniques, we have developed an original processing sequence for the fabrication of silicon oxide enclosed pillar arrays integrated within a fluidic channel. These pillar arrays create a highly uniform submicron scale architecture of solid supports for subsequent stationary phase – mobile phase interactions, while demonstrating substantial improvements in separation efficiency and permeability over traditional packed bed and monolithic columns. The general performance of these microfluidic devices is studied by optimizing the chip architecture and instrumental design to improve the stability of the pillar arrays, improve the sample injection, enhance the pillar surface characteristics, and improve the separation performance. We additionally explore simple and straightforward stationary phase modification techniques for partition based chromatography. Finally, we address the detection challenges of our design by creating the first fully integrated microfluidic chip based platform to combine separation capabilities with real time surface enhanced Raman detection.

Subjects/Keywords: microfluidic; pressure driven separation; pillar arrays; liquid chromatography; Analytical Chemistry

…58 3. Enclosed pillar arrays integrated on a fluidic platform for on-chip separations and… …enclosed pillar arrays ….. 63 3.3.2 Sealing procedure ... 67 3.3.3… …of fabricated pillar arrays ….. 66 Table 3.2 10-port valve for injecting sample plugs… …characterization of the chips with pillar arrays… 69 Fig. 3.3 Top: Cross-sectional SEM images… …favor of perfectly ordered pillar arrays was shown. The main conclusion of this study is that… 

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APA (6th Edition):

Taylor, L. C. (2012). The fabrication and integration of pillar array channels for chip based separations and analysis. (Doctoral Dissertation). University of Tennessee – Knoxville. Retrieved from https://trace.tennessee.edu/utk_graddiss/1355

Chicago Manual of Style (16th Edition):

Taylor, Lisa Christine. “The fabrication and integration of pillar array channels for chip based separations and analysis.” 2012. Doctoral Dissertation, University of Tennessee – Knoxville. Accessed January 23, 2019. https://trace.tennessee.edu/utk_graddiss/1355.

MLA Handbook (7th Edition):

Taylor, Lisa Christine. “The fabrication and integration of pillar array channels for chip based separations and analysis.” 2012. Web. 23 Jan 2019.

Vancouver:

Taylor LC. The fabrication and integration of pillar array channels for chip based separations and analysis. [Internet] [Doctoral dissertation]. University of Tennessee – Knoxville; 2012. [cited 2019 Jan 23]. Available from: https://trace.tennessee.edu/utk_graddiss/1355.

Council of Science Editors:

Taylor LC. The fabrication and integration of pillar array channels for chip based separations and analysis. [Doctoral Dissertation]. University of Tennessee – Knoxville; 2012. Available from: https://trace.tennessee.edu/utk_graddiss/1355

2. Kirchner, Teresa Byers. The fabrication of micro- and nano- scale deterministic and stochastic pillar arrays for planar separations.

Degree: 2015, University of Tennessee – Knoxville

Planar chromatography, unlike high performance liquid chromatography (HPLC), has not experienced a significant evolution in stationary phase media since the development of the technique. This has lead HPLC to become a much more popular and robust analytical method. Main factors that contribute to improved performance of chromatographic systems include a reduction in particle size, homogeneity of the stationary phase, and an increase in velocity of the mobile phase. In general, a reduction in particle size should lead to an improvement in the performance of all chromatography systems. However, the main obstacle of improving the performance of planar chromatography systems is that a reduction in particle size leads to a reduction in the capillary flow that governs solvent velocity. This decrease in solvent velocity leads to band broadening resulting in poor efficiency and resolution which are critical performance parameters for chromatographic systems. The research presented herein investigates the scaling down of dimensions to the micro- and nano-scale for pillar arrays in order to investigate the effect on plate height and chromatographic efficiency of these capillary action driven micro- and nano-fluidic systems. Sample application is a critical parameter that effects band broadening in UTLC systems. By taking advantage of the superhydrophobic nature of these arrays the development of a spotting method that demonstrates the ability to create reproducible sample spots that are less than 200 microns (micro- scale arrays) and 400nm (nano- scale arrays) within these arrays are highlighted in this dissertation. We have demonstrated the fabrication of deterministic micro-scale arrays that exhibit plate heights as low as 2µm as well as deterministic and stochastic nanothin-layer chromatographic platforms. Most significantly these systems resulted in bands that were highly efficient, with plate heights in the nm range. This resulted in significant separations of analytical laser test dyes, environmentally significant NBD-derivatized amines, and, biologically relevant chemotherapy drugs (Adriamycin and Daunorubicin).

Subjects/Keywords: Chromatography; Lithography; Separations; Microfluidics; Ultrathin-Layer Chromatography; Pillar Arrays; Analytical Chemistry

…50 Chapter 3 Deterministic micro-scale silicon pillar arrays as platforms for reverse phase… …53 vi 3.3 Chip design and fabrication of open pillar arrays for separations… …75 Chapter 4 Deterministic and stochastic nanoscale pillar arrays for separations… …32 Figure 2.3.1: (A) Wafer layout of photolithographic pillar arrays and, (B… …Bosch process . 43 Figure 2.6.2: SEM image of pillar arrays before (inset) and after… 

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Kirchner, T. B. (2015). The fabrication of micro- and nano- scale deterministic and stochastic pillar arrays for planar separations. (Doctoral Dissertation). University of Tennessee – Knoxville. Retrieved from https://trace.tennessee.edu/utk_graddiss/3344

Chicago Manual of Style (16th Edition):

Kirchner, Teresa Byers. “The fabrication of micro- and nano- scale deterministic and stochastic pillar arrays for planar separations.” 2015. Doctoral Dissertation, University of Tennessee – Knoxville. Accessed January 23, 2019. https://trace.tennessee.edu/utk_graddiss/3344.

MLA Handbook (7th Edition):

Kirchner, Teresa Byers. “The fabrication of micro- and nano- scale deterministic and stochastic pillar arrays for planar separations.” 2015. Web. 23 Jan 2019.

Vancouver:

Kirchner TB. The fabrication of micro- and nano- scale deterministic and stochastic pillar arrays for planar separations. [Internet] [Doctoral dissertation]. University of Tennessee – Knoxville; 2015. [cited 2019 Jan 23]. Available from: https://trace.tennessee.edu/utk_graddiss/3344.

Council of Science Editors:

Kirchner TB. The fabrication of micro- and nano- scale deterministic and stochastic pillar arrays for planar separations. [Doctoral Dissertation]. University of Tennessee – Knoxville; 2015. Available from: https://trace.tennessee.edu/utk_graddiss/3344

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