subject:(Phthalates)

Texas Tech University

1. Wooten, Kimberly. Potential sources of exposure to endocrine-disrupting chemicals among companion canines.

Degree: MS, Environmental Toxicology, 2012, Texas Tech University

► Effects of environmental chemicals on companion animals are considerably understudied as compared to humans, even though they often occupy similar environs and are exposed via… (more)

Subjects/Keywords: Phthalates; Bisphenol A; Pet Canines

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APA (6^th Edition):

Wooten, K. (2012). Potential sources of exposure to endocrine-disrupting chemicals among companion canines. (Masters Thesis). Texas Tech University. Retrieved from http://hdl.handle.net/2346/73882

Chicago Manual of Style (16^th Edition):

Wooten, Kimberly. “Potential sources of exposure to endocrine-disrupting chemicals among companion canines.” 2012. Masters Thesis, Texas Tech University. Accessed January 18, 2021. http://hdl.handle.net/2346/73882.

MLA Handbook (7^th Edition):

Wooten, Kimberly. “Potential sources of exposure to endocrine-disrupting chemicals among companion canines.” 2012. Web. 18 Jan 2021.

Vancouver:

Wooten K. Potential sources of exposure to endocrine-disrupting chemicals among companion canines. [Internet] [Masters thesis]. Texas Tech University; 2012. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2346/73882.

Council of Science Editors:

Wooten K. Potential sources of exposure to endocrine-disrupting chemicals among companion canines. [Masters Thesis]. Texas Tech University; 2012. Available from: http://hdl.handle.net/2346/73882

University of Ottawa

2. McCormack, Daniel. The Associations Between Bisphenol A and Phthalates, and Measures of Adiposity Among Canadians .

Degree: 2016, University of Ottawa

URL: http://hdl.handle.net/10393/34349

► Bisphenol A (BPA) and phthalates are chemicals found in many consumer products including water bottles, food packaging and cosmetics. Previous research has shown that there… (more)

Subjects/Keywords: bisphenol A; obesity; complex survey; phthalates

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APA (6^th Edition):

McCormack, D. (2016). The Associations Between Bisphenol A and Phthalates, and Measures of Adiposity Among Canadians . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/34349

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McCormack, Daniel. “The Associations Between Bisphenol A and Phthalates, and Measures of Adiposity Among Canadians .” 2016. Thesis, University of Ottawa. Accessed January 18, 2021. http://hdl.handle.net/10393/34349.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McCormack, Daniel. “The Associations Between Bisphenol A and Phthalates, and Measures of Adiposity Among Canadians .” 2016. Web. 18 Jan 2021.

Vancouver:

McCormack D. The Associations Between Bisphenol A and Phthalates, and Measures of Adiposity Among Canadians . [Internet] [Thesis]. University of Ottawa; 2016. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10393/34349.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McCormack D. The Associations Between Bisphenol A and Phthalates, and Measures of Adiposity Among Canadians . [Thesis]. University of Ottawa; 2016. Available from: http://hdl.handle.net/10393/34349

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Ottawa

3. Go, Jennifer. Investigations Into the Effects of Gestational Exposure to Environmental Phthalates on Maternal and Perinatal Outcomes and the Role of Inflammation Biomarkers as Potential Mediators .

Degree: 2017, University of Ottawa

URL: http://hdl.handle.net/10393/36925

► Objectives The aims of this thesis were to (1) investigate the association of gestational exposure to environmental phthalates with maternal and perinatal outcomes, and (2)… (more)

▼ Objectives The aims of this thesis were to (1) investigate the association of gestational exposure to environmental phthalates with maternal and perinatal outcomes, and (2) explore phthalate-induced changes to maternal inflammatory responses as potential mediators of possible health effects. Methods A systematic review was performed to summarize existing evidence on the association of gestational exposure to phthalates with obstetrical outcomes, including pre-eclampsia (PE), pregnancy-induced hypertension (PIH), gestational diabetes mellitus (GDM), intrauterine growth restriction (IUGR), birth weight (BW), head circumference (HC), gestational age (GA), preterm birth (PB), and Apgar scores (AS). Additionally, a secondary analysis of data from the MIREC Study was conducted to evaluate the association of phthalate metabolites with clinical outcomes in the mother and infant using multiple linear and logistic regression, and with inflammatory biomarkers using multinomial logistic regression. Results The systematic review identified a total of 24 articles, and observed inconsistent evidence on BW, HC, GA, and PB, a paucity of research on IUGR, PE, GDM, and AS, and a lack of studies on PIH. However, among studies with statistically significant (p<0.05) results, most suggest an association of phthalates with decreased BW and GA, and increased HC and PB. Findings from the MIREC Study indicate a significant (p<0.01) positive association between MBP and HC among female infants; however, null results were identified for BW, GA, PB, AS, and PIH. In relation to the exposure to phthalates, general trends among suggestive associations (p<0.05) for head circumference showed consistent increases in females and decreases in males, and for gestational age displayed decreases in both stratums. Additionally, a significant positive association of MBzP and ∑DEHP was observed with high MMP-2 and low VCAM levels, respectively. Results approaching statistical significance demonstrated a positive association of ∑DEHP with low MCP1 and ICAM levels, MCPP with low GMCSF levels, MBzP with low CRP and high ICAM levels, and MEP with high MMP-7 and IL-2 levels. Conclusion From the systematic review, the effects of phthalates on maternal and perinatal health remain unclear, possibly due to sources of heterogeneity and challenges in exposure assessment. In the MIREC Study cohort, phthalate levels were associated with GA and HC in infants in a sex-specific manner. Phthalates also appear to influence the circulating inflammatory marker levels, possibly explaining the observed adverse effects. Future research is needed to validate these findings.

Subjects/Keywords: Phthalates; Inflammation Biomarkers; Maternal Outcomes; Perinatal Outcomes

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APA (6^th Edition):

Go, J. (2017). Investigations Into the Effects of Gestational Exposure to Environmental Phthalates on Maternal and Perinatal Outcomes and the Role of Inflammation Biomarkers as Potential Mediators . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/36925

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Go, Jennifer. “Investigations Into the Effects of Gestational Exposure to Environmental Phthalates on Maternal and Perinatal Outcomes and the Role of Inflammation Biomarkers as Potential Mediators .” 2017. Thesis, University of Ottawa. Accessed January 18, 2021. http://hdl.handle.net/10393/36925.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Go, Jennifer. “Investigations Into the Effects of Gestational Exposure to Environmental Phthalates on Maternal and Perinatal Outcomes and the Role of Inflammation Biomarkers as Potential Mediators .” 2017. Web. 18 Jan 2021.

Vancouver:

Go J. Investigations Into the Effects of Gestational Exposure to Environmental Phthalates on Maternal and Perinatal Outcomes and the Role of Inflammation Biomarkers as Potential Mediators . [Internet] [Thesis]. University of Ottawa; 2017. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10393/36925.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Go J. Investigations Into the Effects of Gestational Exposure to Environmental Phthalates on Maternal and Perinatal Outcomes and the Role of Inflammation Biomarkers as Potential Mediators . [Thesis]. University of Ottawa; 2017. Available from: http://hdl.handle.net/10393/36925

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Washington

4. Upson, Kristen. Organochlorine pesticides, phthalate metabolites, and risk of endometriosis.

Degree: PhD, 2013, University of Washington

URL: http://hdl.handle.net/1773/23746

► Background: Endometriosis is an estrogen-driven benign gynecologic condition that may be affected by exposure to environmental chemicals that mimic or alter endogenous hormonal activity, such… (more)

▼ Background: Endometriosis is an estrogen-driven benign gynecologic condition that may be affected by exposure to environmental chemicals that mimic or alter endogenous hormonal activity, such as organochlorine pesticides (OCPs) and phthalates. However, the impact of these chemicals on endometriosis risk remains unclear, as prior epidemiologic studies have had conflicting results. Additionally, basic information is lacking on characteristics associated with increased phthalate body burden among premenopausal women. Methods: This research investigated the relationships between OCPs, phthalate metabolites, and endometriosis risk and predictors of phthalate exposure using data from a population-based case-control study of endometriosis, Women's Risk of Endometriosis (WREN). WREN was conducted among 18-49 year old female enrollees of a large healthcare system in the U.S. Pacific Northwest. OCP concentrations were measured in the serum of 248 cases and 538 controls and urinary phthalate metabolites were quantified on 92 cases and 195 controls. To investigate the relationship between environmental chemicals and endometriosis risk, odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression. To examine predictors of phthalate exposure, ratios of median phthalate metabolite concentrations and 95% CI were estimated using linear regression. Results: Serum concentrations of β-hexachlorocyclohexane, particularly in analyses restricting cases to those with ovarian endometriosis, and mirex were associated with increased endometriosis risk. A strong inverse association was observed between urinary mono-(2-ethyl-5-hexyl) phthalate (MEHP) concentration and endometriosis risk. The data suggested an inverse association with other di-2-ethylhexyl phthalate (DEHP) metabolites and a positive association with mono-benzyl phthalate (MBzP) and mono-ethyl phthalate (MEP). Mono-isobutyl phthalate (MiBP) concentrations were inversely associated with waist circumference and waist-to-hip ratio. Trends across hours of the day (summed metabolites of DEHP), days of the week (MEP), and seasons of the year (MiBP) were observed. Conclusions: This research suggests that environmental exposure to OCPs and phthalates may alter endometriosis risk and that subgroups of premenopausal women may have increased phthalate exposure. Nearly ubiquitous exposure to phthalates as well as extensive past use of environmentally persistent OCPs in the United States or present use in other countries may impact the current health of reproductive-age women. Advisors/Committee Members: Holt, Victoria L (advisor).

Subjects/Keywords: Endometriosis; Organochlorine pesticides; Phthalates; Epidemiology; epidemiology

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APA (6^th Edition):

Upson, K. (2013). Organochlorine pesticides, phthalate metabolites, and risk of endometriosis. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/23746

Chicago Manual of Style (16^th Edition):

Upson, Kristen. “Organochlorine pesticides, phthalate metabolites, and risk of endometriosis.” 2013. Doctoral Dissertation, University of Washington. Accessed January 18, 2021. http://hdl.handle.net/1773/23746.

MLA Handbook (7^th Edition):

Upson, Kristen. “Organochlorine pesticides, phthalate metabolites, and risk of endometriosis.” 2013. Web. 18 Jan 2021.

Vancouver:

Upson K. Organochlorine pesticides, phthalate metabolites, and risk of endometriosis. [Internet] [Doctoral dissertation]. University of Washington; 2013. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1773/23746.

Council of Science Editors:

Upson K. Organochlorine pesticides, phthalate metabolites, and risk of endometriosis. [Doctoral Dissertation]. University of Washington; 2013. Available from: http://hdl.handle.net/1773/23746

5. Norman, Belinda. Giftfria förskolor i Nordmalings kommun : En inventering av förskolor med åtgärdsförslag för att möjliggöra en minskning av barns negativa hälsoeffekter till följd av kemikalieexponering.

Degree: Ecology and Environmental Sciences, 2016, Umeå University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-123219

► Humans are exposed to chemicals every day in our indoor environment. Chemicals have contributed to increased prosperity but also caused negative health effects. Children… (more)

Subjects/Keywords: health effects; phthalates; bisphenol A; perfluorinated compounds; flame retardants

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APA (6^th Edition):

Norman, B. (2016). Giftfria förskolor i Nordmalings kommun : En inventering av förskolor med åtgärdsförslag för att möjliggöra en minskning av barns negativa hälsoeffekter till följd av kemikalieexponering. (Thesis). Umeå University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-123219

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Norman, Belinda. “Giftfria förskolor i Nordmalings kommun : En inventering av förskolor med åtgärdsförslag för att möjliggöra en minskning av barns negativa hälsoeffekter till följd av kemikalieexponering.” 2016. Thesis, Umeå University. Accessed January 18, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-123219.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Norman, Belinda. “Giftfria förskolor i Nordmalings kommun : En inventering av förskolor med åtgärdsförslag för att möjliggöra en minskning av barns negativa hälsoeffekter till följd av kemikalieexponering.” 2016. Web. 18 Jan 2021.

Vancouver:

Norman B. Giftfria förskolor i Nordmalings kommun : En inventering av förskolor med åtgärdsförslag för att möjliggöra en minskning av barns negativa hälsoeffekter till följd av kemikalieexponering. [Internet] [Thesis]. Umeå University; 2016. [cited 2021 Jan 18]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-123219.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Norman B. Giftfria förskolor i Nordmalings kommun : En inventering av förskolor med åtgärdsförslag för att möjliggöra en minskning av barns negativa hälsoeffekter till följd av kemikalieexponering. [Thesis]. Umeå University; 2016. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-123219

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Edinburgh

6. Jobling, Matthew S. Fetal germ cell development in the rat testis and the impact of di (n-Butyl) phthalate exposure.

Degree: PhD, 2010, University of Edinburgh

URL: http://hdl.handle.net/1842/4803

► During gonad development and fetal life, the germ cells (GC) undergo a range of different developmental processes necessary for correct postnatal gametogenesis and the production… (more)

▼ During gonad development and fetal life, the germ cells (GC) undergo a range of different developmental processes necessary for correct postnatal gametogenesis and the production of the next generation. If these fetal events are disrupted by genetic or environmental factors, there could be severe consequences that may not present until adulthood. This is of particular importance in relation to human testicular GC tumours (TGCT), the most common cancer of young men, as TGCT is thought to arise from fetal GCs that have failed to differentiate normally during development and thus persist into adulthood, eventually becoming tumourigenic. TGCT is one of several related disorders of male reproductive health thought to comprise a Testicular Dysgenesis Syndrome (TDS), in which faulty testis development in fetal life may predispose to the development of cryptorchidism, hypospadias, reduced sperm count and TGCT. Currently there is no accepted animal model for TGCT, but some insight into human TDS has been gained through the use of a rat model using in utero Di (n-Butyl) Phthalate (DBP) exposure to induce cryptorchidism, hypospadias, low sperm count and reduced fertility (but not TGCT). However, a previous study suggested that DBP exposure can disrupt GC differentiation, resulting in significantly reduced GC number prior to birth and postnatal consequences. This thesis has been directed at investigating the normal process of GC development in the fetal rat and how this is altered by DBP exposure; such understanding may give insights into the origins of human TGCT by showing how and when disruption of normal fetal GC differentiation can occur. The first objective was to characterise GC development in both the rat testis and ovary to understand the normal events that occur between embryonic day (e)13.5 and e21.5, as most data in the literature is based on the mouse. Analysis by immunohistochemical, stereological and mRNA expression indentified that during this time period, a GC will undergo a dynamic sequence of changes involving migration, proliferation followed by differentiation (manifested by loss of specific protein markers), whilst undergoing germ-line specific remethylation. Whilst whole gonad development is vastly different between testes and ovaries, GC development was broadly the same with only minor differences up to the point where GCs in the ovary enter meiosis. Having established the normal process of GC development in the fetal rat testis, the effects of in utero DBP exposure was then investigated. DBP exposure reduced GC number at all ages investigated even after only 24 hours of exposure and simultaneously prolonged GC proliferation. As apoptosis was unaltered by DBP exposure, the consistent reduction in GC number was suggested to be due to an initial reduction in GC number that does not recover to control levels. GC differentiation was assessed by the expression and localization of specific protein markers (OCT4, DMRT1 and DAZL). The pattern of expression of OCT4 and DMRT1 was altered by DBP exposure. GCs in DBP…

Subjects/Keywords: 612.6; testis; germ cell; phthalates

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APA (6^th Edition):

Jobling, M. S. (2010). Fetal germ cell development in the rat testis and the impact of di (n-Butyl) phthalate exposure. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/4803

Chicago Manual of Style (16^th Edition):

Jobling, Matthew S. “Fetal germ cell development in the rat testis and the impact of di (n-Butyl) phthalate exposure.” 2010. Doctoral Dissertation, University of Edinburgh. Accessed January 18, 2021. http://hdl.handle.net/1842/4803.

MLA Handbook (7^th Edition):

Jobling, Matthew S. “Fetal germ cell development in the rat testis and the impact of di (n-Butyl) phthalate exposure.” 2010. Web. 18 Jan 2021.

Vancouver:

Jobling MS. Fetal germ cell development in the rat testis and the impact of di (n-Butyl) phthalate exposure. [Internet] [Doctoral dissertation]. University of Edinburgh; 2010. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1842/4803.

Council of Science Editors:

Jobling MS. Fetal germ cell development in the rat testis and the impact of di (n-Butyl) phthalate exposure. [Doctoral Dissertation]. University of Edinburgh; 2010. Available from: http://hdl.handle.net/1842/4803

7. Larsson, Jon. Förekomst av ftalater i Umeås spillvatten : En kartläggning av mängden ftalater i de olika upptagningsområdena till Öns avloppsreningsverk.

Degree: Ecology and Environmental Sciences, 2017, Umeå University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-136670

► The purpose of this study was to analyze the amount of phthalates in the wastewater in Umeå and if possible determine if specific areas… (more)

Subjects/Keywords: phthalates; diffuse leakage; point source; Öns WWTP; Natural Sciences; Naturvetenskap

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APA (6^th Edition):

Larsson, J. (2017). Förekomst av ftalater i Umeås spillvatten : En kartläggning av mängden ftalater i de olika upptagningsområdena till Öns avloppsreningsverk. (Thesis). Umeå University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-136670

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Larsson, Jon. “Förekomst av ftalater i Umeås spillvatten : En kartläggning av mängden ftalater i de olika upptagningsområdena till Öns avloppsreningsverk.” 2017. Thesis, Umeå University. Accessed January 18, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-136670.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Larsson, Jon. “Förekomst av ftalater i Umeås spillvatten : En kartläggning av mängden ftalater i de olika upptagningsområdena till Öns avloppsreningsverk.” 2017. Web. 18 Jan 2021.

Vancouver:

Larsson J. Förekomst av ftalater i Umeås spillvatten : En kartläggning av mängden ftalater i de olika upptagningsområdena till Öns avloppsreningsverk. [Internet] [Thesis]. Umeå University; 2017. [cited 2021 Jan 18]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-136670.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Larsson J. Förekomst av ftalater i Umeås spillvatten : En kartläggning av mängden ftalater i de olika upptagningsområdena till Öns avloppsreningsverk. [Thesis]. Umeå University; 2017. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-136670

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Uppsala University

8. Balck, Marianne. Phthalates in preschool dust : the relation between phthalates and parameters in the preschool environment.

Degree: Biology Education Centre, 2015, Uppsala University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-262076

► Children are constantly exposed to many chemicals via the products they come in contactwith in their everyday life. One chemical group is phthalates, the… (more)

▼ Children are constantly exposed to many chemicals via the products they come in contactwith in their everyday life. One chemical group is phthalates, the most commonly usedplasticisers in the world. Phthalates are used mainly in PVC plastic products like floors, toys,food containers and wallpaper but they are also used in rubber, glue, paint, cables etc. Sincethese chemicals are weakly chemically bound to the PVC they can leak and migrate to the air,food, water and skin. Children are exposed to phthalates mainly through food, but because ofthe hand to mouth behaviour they are also exposed via dust inhalation and dust ingestion.About ten years ago regulations of the most toxic phthalates in toys and child care productswere implemented in the EU and from February 2015 it is a general prohibition for the use ofDEHP (diethylhexyl phthalate), DnBP (di-n-butyl phthalate), DiBP (diisobutyl phthalate) andBBzP (butyl benzyl phthalate). DiNP (diisononyl phthalate) is a relatively new phthalate andit has replaced DEHP to some extent in floors and toys. In phthalate free products DINCH(1,2-cyclohexane dicarboxylic acid diisononyl ester) is one of the plasticizer replacingphthalates. The banned phthalates have been shown to cause adverse effects on reproductionand recent research also investigates links between phthalate exposure and asthma and allergysymptoms in children. More experimental animal studies are needed to further investigate theasthma and allergy correlation. In the present project dust samples were collected from 30 preschool indoor environments inthe Stockholm city area to evaluate the levels of the six substances mentioned and thephthalate DEP (diethyl phthalate). The main aim of this thesis project was to search forrelations and links between the phthalate concentrations in dust and parameters from theindoor environment in preschools. Studied parameters are e.g. construction year, floor type,cleaning routines and quantity of toys and furniture made of plastic or foam. The project wascommissioned by the Swedish EPA and performed at the Institute of Environmental Medicine(IMM) at Karolinska Institutet. A negative relation was found between dust phthalate (DEHP and DnBP) concentrationand construction year. Also rooms with old PVC floors had higher concentrations of DEHPand DnBP in dust than rooms with new PVC floors. There was also a trend that dust frompreschools with PVC floors had higher DiNP concentration than dust from preschools withother floor types. The preschools that used foam mattresses for resting had higher DiNPconcentrations than those with no foam mattresses. Most preschools had new foammattresses, which could indicate a more common use of DiNP in new mattresses or mattress2covers compared to old mattresses that contains more DEHP. The four Waldorf preschoolsthat participated had lower DiNP dust concentrations than the other preschools, which wasexpected since Waldorf orientation includes using as little plastic material as possible. Norelation was found between the…

Subjects/Keywords: phthalates; preschool; dust; chemicals; relation; correlation; children; kids; toys; buildings

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APA (6^th Edition):

Balck, M. (2015). Phthalates in preschool dust : the relation between phthalates and parameters in the preschool environment. (Thesis). Uppsala University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-262076

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Balck, Marianne. “Phthalates in preschool dust : the relation between phthalates and parameters in the preschool environment.” 2015. Thesis, Uppsala University. Accessed January 18, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-262076.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Balck, Marianne. “Phthalates in preschool dust : the relation between phthalates and parameters in the preschool environment.” 2015. Web. 18 Jan 2021.

Vancouver:

Balck M. Phthalates in preschool dust : the relation between phthalates and parameters in the preschool environment. [Internet] [Thesis]. Uppsala University; 2015. [cited 2021 Jan 18]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-262076.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Balck M. Phthalates in preschool dust : the relation between phthalates and parameters in the preschool environment. [Thesis]. Uppsala University; 2015. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-262076

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

KTH

9. Tommie, Ibert. Phthalate replacement by fast fusing non-phthalate plasticizer.

Degree: Chemical Science and Engineering (CHE), 2016, KTH

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-184858

► A key trend in the PVC market is to replace or decrease the amount of phthalate plasticisers used due to increasing health concerns. Therefore,… (more)

▼ A key trend in the PVC market is to replace or decrease the amount of phthalate plasticisers used due to increasing health concerns. Therefore, the demand for non-phthalate based plasticisers is growing rapidly. Mineral oils are used in a variety of rubber and polymer applications as plasticisers; however, due to the lower polarity their applicability in PVC compounds is limited. Therefore, these materials are typically used as secondary plasticiser along with a primary for the purpose of improved properties and cost reduction. Some of the non-phthalate based solutions are fast fusing plasticisers, which act like solvents and have too rapid and too high plasticizing effect. This makes the compounding difficult and could cause problems in production. These substances have good compatibility with mineral oils, and using them together in PVC compounds can help the compounding issue by reducing the solvent power and increasing the fusion time to a level where the production parameters are similar to compounding with phthalates. The aim of this study was to evaluate the use of mineral oils as a secondary plasticiser in a non-phthalate system for PVC. Four different grades of mineral oil and three non-phthalate plasticisers were used in compounding and compression moulding of PVC sample films. Mechanical, physical and chemical testing were done to assess the properties in a comparative study with phthalate plasticized PVC. Tensile testing and hardness measurements showed that the mineral oils did not contribute with any plasticizing effect for the non-phthalate plasticisers tested in the study. The hardness was instead slightly increased for all the sample films that contained mineral oil. This indicates that the mineral oil either is less efficient than the primary plasticiser or that it affects the primary plasticisers intramolecular shielding between the PVC chains. The shrinkage test showed that the migration of mineral oil was acceptable, especially the thicker grades of mineral oils had low migration. Colour stability test showed that the thicker mineral oil grades had some problems with discolouration. The discolouration is probably related to content of polyaromatics and oxidation stability.

Subjects/Keywords: Non-phthalate; PVC; Plasticiser; Phthalates; Oil; Fusion; Gelation; Phthalate free

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tommie, I. (2016). Phthalate replacement by fast fusing non-phthalate plasticizer. (Thesis). KTH. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-184858

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tommie, Ibert. “Phthalate replacement by fast fusing non-phthalate plasticizer.” 2016. Thesis, KTH. Accessed January 18, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-184858.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tommie, Ibert. “Phthalate replacement by fast fusing non-phthalate plasticizer.” 2016. Web. 18 Jan 2021.

Vancouver:

Tommie I. Phthalate replacement by fast fusing non-phthalate plasticizer. [Internet] [Thesis]. KTH; 2016. [cited 2021 Jan 18]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-184858.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tommie I. Phthalate replacement by fast fusing non-phthalate plasticizer. [Thesis]. KTH; 2016. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-184858

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Lund

10. Ode, Amanda. Environmental Toxins and Essential Trace Elements at Delivery and ADHD.

Degree: 2015, University of Lund

URL: https://lup.lub.lu.se/record/5276947 ; https://portal.research.lu.se/ws/files/4042694/5276958.pdf

► Perfluorinated compounds (PFCs), phthalates, manganese and selenium are ubiquitous in the environment and humans and influence fetal growth and development. Register and biobank based case-control… (more)

Subjects/Keywords: Environmental Health and Occupational Health; PFCs; manganese; selenium; phthalates; ADHD; fetus

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APA (6^th Edition):

Ode, A. (2015). Environmental Toxins and Essential Trace Elements at Delivery and ADHD. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/5276947 ; https://portal.research.lu.se/ws/files/4042694/5276958.pdf

Chicago Manual of Style (16^th Edition):

Ode, Amanda. “Environmental Toxins and Essential Trace Elements at Delivery and ADHD.” 2015. Doctoral Dissertation, University of Lund. Accessed January 18, 2021. https://lup.lub.lu.se/record/5276947 ; https://portal.research.lu.se/ws/files/4042694/5276958.pdf.

MLA Handbook (7^th Edition):

Ode, Amanda. “Environmental Toxins and Essential Trace Elements at Delivery and ADHD.” 2015. Web. 18 Jan 2021.

Vancouver:

Ode A. Environmental Toxins and Essential Trace Elements at Delivery and ADHD. [Internet] [Doctoral dissertation]. University of Lund; 2015. [cited 2021 Jan 18]. Available from: https://lup.lub.lu.se/record/5276947 ; https://portal.research.lu.se/ws/files/4042694/5276958.pdf.

Council of Science Editors:

Ode A. Environmental Toxins and Essential Trace Elements at Delivery and ADHD. [Doctoral Dissertation]. University of Lund; 2015. Available from: https://lup.lub.lu.se/record/5276947 ; https://portal.research.lu.se/ws/files/4042694/5276958.pdf

University of Guelph

11. Sritharan, Abiran. Peroxisome proliferator-activated receptors (PPARs), phthalates and reproduction in the female zebrafish (Danio rerio).

Degree: MS, Department of Integrative Biology, 2017, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/11939

► Peroxisome proliferator-activated receptors are nuclear transcription factors that mediate a wide array of physiological processes in mammals including reproduction. The objective of this thesis was… (more)

Subjects/Keywords: PPARs; phthalates; zebrafish; ppar gamma; ppar alpha; ppar beta; dehp; mehp

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APA (6^th Edition):

Sritharan, A. (2017). Peroxisome proliferator-activated receptors (PPARs), phthalates and reproduction in the female zebrafish (Danio rerio). (Masters Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/11939

Chicago Manual of Style (16^th Edition):

Sritharan, Abiran. “Peroxisome proliferator-activated receptors (PPARs), phthalates and reproduction in the female zebrafish (Danio rerio).” 2017. Masters Thesis, University of Guelph. Accessed January 18, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/11939.

MLA Handbook (7^th Edition):

Sritharan, Abiran. “Peroxisome proliferator-activated receptors (PPARs), phthalates and reproduction in the female zebrafish (Danio rerio).” 2017. Web. 18 Jan 2021.

Vancouver:

Sritharan A. Peroxisome proliferator-activated receptors (PPARs), phthalates and reproduction in the female zebrafish (Danio rerio). [Internet] [Masters thesis]. University of Guelph; 2017. [cited 2021 Jan 18]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/11939.

Council of Science Editors:

Sritharan A. Peroxisome proliferator-activated receptors (PPARs), phthalates and reproduction in the female zebrafish (Danio rerio). [Masters Thesis]. University of Guelph; 2017. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/11939

University of Maryland

12. Bibb, Katrina Alexandra. INVESTIGATING THE ASSOCIATION OF PHTHALATE EXPOSURES AND ADVERSE REPRODUCTIVE HEALTH OUTCOMES IN A REPRESENTATIVE SAMPLE OF U.S. WOMEN.

Degree: Environmental Science and Technology, 2017, University of Maryland

URL: http://hdl.handle.net/1903/20296

► Phthalates are endocrine disrupting chemicals present in a large variety of consumer goods. There is supporting evidence from animal studies that exposure to phthalates affect… (more)

Subjects/Keywords: Environmental health; Epidemiology; Health sciences; environmental epidemiology; NHANES; phthalates; reproductive health

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APA (6^th Edition):

Bibb, K. A. (2017). INVESTIGATING THE ASSOCIATION OF PHTHALATE EXPOSURES AND ADVERSE REPRODUCTIVE HEALTH OUTCOMES IN A REPRESENTATIVE SAMPLE OF U.S. WOMEN. (Thesis). University of Maryland. Retrieved from http://hdl.handle.net/1903/20296

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bibb, Katrina Alexandra. “INVESTIGATING THE ASSOCIATION OF PHTHALATE EXPOSURES AND ADVERSE REPRODUCTIVE HEALTH OUTCOMES IN A REPRESENTATIVE SAMPLE OF U.S. WOMEN.” 2017. Thesis, University of Maryland. Accessed January 18, 2021. http://hdl.handle.net/1903/20296.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bibb, Katrina Alexandra. “INVESTIGATING THE ASSOCIATION OF PHTHALATE EXPOSURES AND ADVERSE REPRODUCTIVE HEALTH OUTCOMES IN A REPRESENTATIVE SAMPLE OF U.S. WOMEN.” 2017. Web. 18 Jan 2021.

Vancouver:

Bibb KA. INVESTIGATING THE ASSOCIATION OF PHTHALATE EXPOSURES AND ADVERSE REPRODUCTIVE HEALTH OUTCOMES IN A REPRESENTATIVE SAMPLE OF U.S. WOMEN. [Internet] [Thesis]. University of Maryland; 2017. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1903/20296.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bibb KA. INVESTIGATING THE ASSOCIATION OF PHTHALATE EXPOSURES AND ADVERSE REPRODUCTIVE HEALTH OUTCOMES IN A REPRESENTATIVE SAMPLE OF U.S. WOMEN. [Thesis]. University of Maryland; 2017. Available from: http://hdl.handle.net/1903/20296

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Maryland

13. Haque, Mefruz Salwa. Associations between Urinary Phthalates and Metabolic Syndrome in NHANES 2005-2010.

Degree: Epidemiology and Biostatistics, 2015, University of Maryland

URL: http://hdl.handle.net/1903/16802

► Phthalates, commonly used to make plastics more durable, are a group of endocrine disrupting chemicals (EDC), with potential for adverse metabolic consequences. Associations between exposure… (more)

Subjects/Keywords: Epidemiology; Environmental health; epidemiology; metabolic syndrome; metabolites; NHANES; phthalates

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APA (6^th Edition):

Haque, M. S. (2015). Associations between Urinary Phthalates and Metabolic Syndrome in NHANES 2005-2010. (Thesis). University of Maryland. Retrieved from http://hdl.handle.net/1903/16802

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Haque, Mefruz Salwa. “Associations between Urinary Phthalates and Metabolic Syndrome in NHANES 2005-2010.” 2015. Thesis, University of Maryland. Accessed January 18, 2021. http://hdl.handle.net/1903/16802.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Haque, Mefruz Salwa. “Associations between Urinary Phthalates and Metabolic Syndrome in NHANES 2005-2010.” 2015. Web. 18 Jan 2021.

Vancouver:

Haque MS. Associations between Urinary Phthalates and Metabolic Syndrome in NHANES 2005-2010. [Internet] [Thesis]. University of Maryland; 2015. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1903/16802.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Haque MS. Associations between Urinary Phthalates and Metabolic Syndrome in NHANES 2005-2010. [Thesis]. University of Maryland; 2015. Available from: http://hdl.handle.net/1903/16802

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. Olmsted, Alexandra. Sperm Mitochondrial Copy Number and Associations with Oxidative Stress and Phthalate Metabolites in Male Partners Undergoing Assisted Reproductive Technologies.

Degree: University of Massachusetts

URL: https://scholarworks.umass.edu/masters_theses_2/547

► INTRODUCTION Phthalates, a chemical class of plasticizers, are ubiquitous in the environment and recognized as endocrine disrupting compounds (EDCs). Recent data suggest that oxidative… (more)

▼ INTRODUCTION Phthalates, a chemical class of plasticizers, are ubiquitous in the environment and recognized as endocrine disrupting compounds (EDCs). Recent data suggest that oxidative stress is a potential mediator of poor male reproductive health associated with phthalate exposure. Mitochondria are implicated in the production of excess oxidative stress and sperm mitochondrial copy number (MtCopy) and deletions (MtDeletion) have been linked with male infertility. However, little is known about the relationship of these mitochondrial biomarkers in sperm with phthalate exposure and oxidative stress. OBJECTIVES To examine associations of urinary phthalate metabolites and isoprostane concentrations on sperm MtCopy and MtDeletions in male partners undergoing assisted reproductive technologies (ART). METHODS A total of (n=97) sperm samples were collected from male partners undergoing ART at Baystate Medical Center, in Springfield, MA from 2014 to 2016 as part of the Sperm Environmental Epigenetics and Development Study (SEEDS). Seventeen urinary phthalate metabolites (n=103) were analyzed by the Centers for Disease Control using tandem mass spectrometry. 15-F2t-Isoprostane (n=101) was measured using a competitive enzyme-linked immonsorbent assay in urine of male individuals. A triplex Taqman probe-based qPCR method was developed for relative quantification of genomic DNA, MtCopy and MtDeletions. Multivariable linear or logistic regression was employed to examine associations with age, BMI, batch and current smoking status with each outcome to determine confounders used for adjustment. RESULTS Quartiles of MtCopy and MtDeletion were positively associated with the odds of male infertility (p for trend < .0001 and 0.007, respectively). Urinary metabolite concentrations of MCNP displayed a positive association with MtCopy (β=1.56; p =0.03). Urinary MEHP concentrations were positively associated with MtDeletion in only infertile individuals (n=30) (β = 0.075; p = 0.006). Urinary isoprostane concentration was not associated with MtCopy or MtDeletion, but was associated with seven phthalate metabolite concentrations (MEOHP, MEHHP, MBzP, MHBP, MiBP, and MHiBP). CONCLUSIONS To our knowledge, this is the first study to investigate the relationship between sperm MtCopy and MtDeletion with oxidative stress and phthalates. These results suggest that certain phthalate metabolites may be associated with a known biomarker of systemic oxidative stress. Sperm mitochondrial function as measured by MtCopy and MtDeletion may be considered biomarkers of male infertility, although no relationship was shown between mitochondrial outcomes and oxidative stress. Future research is investigating these relationships with developmental outcomes including embryo quality. Advisors/Committee Members: J. Richard Pilsner Richard Pilsner, Alexander Suvorov, Krystal Pollitt.

Subjects/Keywords: isoprostane; infertility; mitochondria; phthalates; sperm

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APA (6^th Edition):

Olmsted, A. (n.d.). Sperm Mitochondrial Copy Number and Associations with Oxidative Stress and Phthalate Metabolites in Male Partners Undergoing Assisted Reproductive Technologies. (Thesis). University of Massachusetts. Retrieved from https://scholarworks.umass.edu/masters_theses_2/547

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Olmsted, Alexandra. “Sperm Mitochondrial Copy Number and Associations with Oxidative Stress and Phthalate Metabolites in Male Partners Undergoing Assisted Reproductive Technologies.” Thesis, University of Massachusetts. Accessed January 18, 2021. https://scholarworks.umass.edu/masters_theses_2/547.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Olmsted, Alexandra. “Sperm Mitochondrial Copy Number and Associations with Oxidative Stress and Phthalate Metabolites in Male Partners Undergoing Assisted Reproductive Technologies.” Web. 18 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Olmsted A. Sperm Mitochondrial Copy Number and Associations with Oxidative Stress and Phthalate Metabolites in Male Partners Undergoing Assisted Reproductive Technologies. [Internet] [Thesis]. University of Massachusetts; [cited 2021 Jan 18]. Available from: https://scholarworks.umass.edu/masters_theses_2/547.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Olmsted A. Sperm Mitochondrial Copy Number and Associations with Oxidative Stress and Phthalate Metabolites in Male Partners Undergoing Assisted Reproductive Technologies. [Thesis]. University of Massachusetts; Available from: https://scholarworks.umass.edu/masters_theses_2/547

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

NSYSU

15. Liu, Te-Lin. Development of Thermal Desorption Electrospray Ionization Mass Spectrometry and its Applications in Food Safety.

Degree: Master, Chemistry, 2012, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0728112-182049

► Ambient ionization mass spectrometry, which has witnessed a flurry of recent developments, is a set of useful techniques for the analysis of samples under open-air… (more)

▼ Ambient ionization mass spectrometry, which has witnessed a flurry of recent developments, is a set of useful techniques for the analysis of samples under open-air conditions. It allows direct, rapid, real-time, high-throughput analysis with little or no sample pretreatment for the chemicals in solids or liquids. In this study, thermal desorption electrospray ionization mass spectrometry ( TD-ESI/MS ) involving direct insertion probe ( DIP ), thermal desorption ( TD ) and electrospray ionization ( ESI ) was used for the rapid screening of various types of samples. The source mainly consists of the sampling probe device, thermal desorption heating device, electrospray ionization device, ion source and temperature controller. A novel strategy involved in TD-ESI/MS processes where sampling, desorption, and ionization are separated as three independent events. The sampling probe is first used for the sampling of analytes and then inserted into a heat unit for thermal desorption. The desorbed analytes are finally carried into a reaction region with a stream of nitrogen gas, where charged methanol droplets were generated continuously by electrospray for post-ionization. Total analysis time is less than 10 seconds. Traditionally, three standard methods are used for the analysis for pesticide residues, biochemical, immunoassay and instrument. And, the instrument analysis is the most widely used because it provides lots of advantages in particularly accurate quantitative approach. However, its complicated steps take a long period of time for preparation. Here, we used TD-ESI/MS to rapidly screen the pesticide residues on the surface of fruits and vegetables. The MS/MS analysis was also performed to confirm those detected compounds. The experimental results of the standard deviation for reproducibility is 13.2% (n = 10), and the detection limit is approximately 10 ppb. Furthermore, several fruits and vegetables purchased from local market were used as test samples and pesticide residues on the surface of samples can be successfully detected via TD-ESI/MS. In addition, the TD-ESI/MS technique was also applied to the analysis of illegal additives or phthalates in food. In this study, the TD-ESI/MS technique emerges lots of advantages such as direct, rapid, real-time analysis of sample surface and sample pretreatment is not necessary, and shows highly potential for rapid screening of chemicals in food safety. Advisors/Committee Members: Jentaie Shiea (committee member), Wei-Lung Tseng (chair), Chien-Chen Lai (committee member).

Subjects/Keywords: ambient ionization mass spectrometry; pesticide residues; phthalates; thermal desorption electrospray ionization mass spectrometry; sampling probe

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APA (6^th Edition):

Liu, T. (2012). Development of Thermal Desorption Electrospray Ionization Mass Spectrometry and its Applications in Food Safety. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0728112-182049

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Liu, Te-Lin. “Development of Thermal Desorption Electrospray Ionization Mass Spectrometry and its Applications in Food Safety.” 2012. Thesis, NSYSU. Accessed January 18, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0728112-182049.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Liu, Te-Lin. “Development of Thermal Desorption Electrospray Ionization Mass Spectrometry and its Applications in Food Safety.” 2012. Web. 18 Jan 2021.

Vancouver:

Liu T. Development of Thermal Desorption Electrospray Ionization Mass Spectrometry and its Applications in Food Safety. [Internet] [Thesis]. NSYSU; 2012. [cited 2021 Jan 18]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0728112-182049.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Liu T. Development of Thermal Desorption Electrospray Ionization Mass Spectrometry and its Applications in Food Safety. [Thesis]. NSYSU; 2012. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0728112-182049

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Berkeley

16. Tuller, David. The (Non) Regulation of Endocrine Disrupting Chemicals.

Degree: Public Health, 2013, University of California – Berkeley

URL: http://www.escholarship.org/uc/item/89s813b1

► This dissertation investigates efforts in the United States to regulate endocrine-disrupting chemicals. 1n 1996, Congress mandated the U.S. Environmental Protection Agency to establish a screening… (more)

▼ This dissertation investigates efforts in the United States to regulate endocrine-disrupting chemicals. 1n 1996, Congress mandated the U.S. Environmental Protection Agency to establish a screening program for chemicals that appeared to interfere with the actions of estrogens, androgens and thyroid hormones; no chemicals have yet proceeded through the full complement of assays, and many details of the program remain unresolved. Moreover, much is still unknown about endocrine-disrupting chemicals, complicating the tasks of assessing and regulating them; for example, there is significant scientific support for the notion that they can exert effects at very low-doses, but industry disputes such findings. Without an effective Endocrine Disruptor Screening Program (EDSP), human and wildlife population continue to be exposed to possible endocrine-disruptors, with long-term consequences that remain unclear. This dissertation examines how industry stakeholders, non-governmental organizations and others have framed the scientific issues and sought to influence regulators, consumers and other audiences, through public comment, ex parte meetings and media coverage. It examines: 1) public comments from stakeholders in response to the first draft list of chemicals for the EDSP; 2) private meetings between industry representatives and the EPA about key aspects of the EDSP; and 3) news coverage of phthalates, and in particular advocacy efforts to raise awareness about their presence in brand-name consumer goods. The results of this investigation suggest that while industry stakeholders might not appear to have significant impact on the content of rules, the regulatory process has nonetheless provided them with multiple opportunities to delay the process of EDSP development. The results also suggest that environmental and public health advocates can find different strategies for effecting policy change, with the news media playing a key role. In particular, offering new forms of evidence and altering public perceptions about the potential hazards of everyday consumer products can exert pressure on corporations to change behaviors and reformulate products, and on politicians to take legislative action against particularly worrisome chemicals. The trade-off is that the benefits might be far narrower in scope – as in this particular case, limited to phthalates in toys and personal care products – than the protections envisioned as part of an overarching structure like the EDSP.

Subjects/Keywords: Environmental health; Public health; Journalism; endocrine disrupting chemical; Endocrine Disruptor Screening Program; phthalates

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APA (6^th Edition):

Tuller, D. (2013). The (Non) Regulation of Endocrine Disrupting Chemicals. (Thesis). University of California – Berkeley. Retrieved from http://www.escholarship.org/uc/item/89s813b1

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tuller, David. “The (Non) Regulation of Endocrine Disrupting Chemicals.” 2013. Thesis, University of California – Berkeley. Accessed January 18, 2021. http://www.escholarship.org/uc/item/89s813b1.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tuller, David. “The (Non) Regulation of Endocrine Disrupting Chemicals.” 2013. Web. 18 Jan 2021.

Vancouver:

Tuller D. The (Non) Regulation of Endocrine Disrupting Chemicals. [Internet] [Thesis]. University of California – Berkeley; 2013. [cited 2021 Jan 18]. Available from: http://www.escholarship.org/uc/item/89s813b1.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tuller D. The (Non) Regulation of Endocrine Disrupting Chemicals. [Thesis]. University of California – Berkeley; 2013. Available from: http://www.escholarship.org/uc/item/89s813b1

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Michigan

17. Ferguson, Kelly K. Environmental Phthalate Exposure, Oxidative Stress, and Preterm Birth.

Degree: PhD, Environmental Health Sciences, 2014, University of Michigan

URL: http://hdl.handle.net/2027.42/107336

► Preterm birth affects over 1 in 10 pregnancies in the US, is a leading contributor of neonatal mortality and morbidities, and has been linked to… (more)

▼ Preterm birth affects over 1 in 10 pregnancies in the US, is a leading contributor of neonatal mortality and morbidities, and has been linked to a number of adverse health outcomes later in life. Despite the severity of the problem, mechanisms of preterm birth are poorly understood, identified causes are few, and preventions are minimally effective. Environmental contributors to preterm birth are understudied but potentially important. Phthalates are a class of chemicals used commonly as plasticizers and solvents in various consumer products. Exposure in the US and elsewhere is ubiquitous. This dissertation provides evidence that maternal exposure to phthalates during pregnancy is associated with preterm birth and that phthalate-induced oxidative stress may play a partial role in mediating this relationship. The nested case-control population examined herein is drawn from a large prospective birth cohort of women recruited early in pregnancy and followed until delivery. Subjects provided urine samples at up to four visits across gestation, which were used for measurement of phthalate metabolites and oxidative stress biomarkers. At delivery, detailed birth outcome data was recorded, including information on preterm etiology. Based on these designations, cases were divided into two groups for the majority of the analysis, including spontaneous preterm births following spontaneous preterm labor and/or preterm premature rupture of the membranes and placental preterm births resulting from preeclampsia and/or intrauterine growth restriction. The results indicated strong associations between maternal phthalate exposure during pregnancy and increased risk of preterm birth, and relationships were strongest in the spontaneous preterm subset. When patterns of urinary phthalate metabolite levels were examined longitudinally across gestation, it became clear that levels measured toward the end of pregnancy were most predictive of prematurity. Oxidative stress biomarkers measured in this study were strongly associated with phthalate metabolites as well as preterm birth. Mediation analysis demonstrated that oxidative stress accounted for 25-50 percent of the association between phthalate exposure and spontaneous preterm birth. These results provide evidence for not only association but causality in the relationship between urinary phthalate metabolites and prematurity. They suggest that women should take steps to decrease exposure levels during pregnancy. Advisors/Committee Members: Meeker, John D. (committee member), Mukherjee, Bhramar (committee member), Loch-Caruso, Rita (committee member), McElrath, Thomas D. (committee member), Harlow, Sioban D. (committee member).

Subjects/Keywords: Environment; Reproductive Epidemiology; Maternal Health; Phthalates; Preterm Birth; Public Health; Health Sciences

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APA (6^th Edition):

Ferguson, K. K. (2014). Environmental Phthalate Exposure, Oxidative Stress, and Preterm Birth. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/107336

Chicago Manual of Style (16^th Edition):

Ferguson, Kelly K. “Environmental Phthalate Exposure, Oxidative Stress, and Preterm Birth.” 2014. Doctoral Dissertation, University of Michigan. Accessed January 18, 2021. http://hdl.handle.net/2027.42/107336.

MLA Handbook (7^th Edition):

Ferguson, Kelly K. “Environmental Phthalate Exposure, Oxidative Stress, and Preterm Birth.” 2014. Web. 18 Jan 2021.

Vancouver:

Ferguson KK. Environmental Phthalate Exposure, Oxidative Stress, and Preterm Birth. [Internet] [Doctoral dissertation]. University of Michigan; 2014. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2027.42/107336.

Council of Science Editors:

Ferguson KK. Environmental Phthalate Exposure, Oxidative Stress, and Preterm Birth. [Doctoral Dissertation]. University of Michigan; 2014. Available from: http://hdl.handle.net/2027.42/107336

Universidade Estadual de Campinas

18. Petrarca, Mateus Henrique, 1983-. Residues and contaminants in baby foods : development and validation of analytical methods = Resíduos e contaminantes em alimentos infantis: desenvolvimento e validação de métodos analíticos: Resíduos e contaminantes em alimentos infantis : desenvolvimento e validação de métodos analíticos.

Degree: 2017, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332308

► Abstract: The aim of this work was to develop, validate and apply analytical methods for the determination of pesticide residues, environmental contaminants (polycyclic aromatic hydrocarbons… (more)

▼ Abstract: The aim of this work was to develop, validate and apply analytical methods for the determination of pesticide residues, environmental contaminants (polycyclic aromatic hydrocarbons - PAHs and phthalates), heat-processing contaminants (acrylamide, 5-hydroxymethylfurfural and 4-hydroxy-2,5-dimethyl-3(2H)-furanone) and the polyamines spermidine and spermine in baby foods. Sample preparation methods coupled to gas chromatography (GC), high performance liquid chromatography (HPLC) and mass spectrometry (MS) were optimized and developed focusing minimal consumption of reagents and organic solvents, and lower generation of chemical residues. QuEChERS (quick, easy, cheap, effective, rugged and safe) combined with dispersive liquid-liquid microextraction (DLLME) presented adequate performance characteristics and analytical sensibility for the monitoring of 24 pesticides at maximum limit residue of 10 µg kg¿1 for baby foods, using GC-MS. As an alternative to GC, a novel HPLC-MS method was developed for simultaneous analysis of natural pyrethrins and pyrethroids residues. For this, a simple and fast sample preparation method based in salting out-assisted liquid-liquid extraction, and other method including ultrasound-assisted DLLME, were evaluated and compared regarding its performance characteristics. PAHs were analyzed using GC-MS; therefore, different miniaturized extraction techniques were combined resulting in a novel selective and sensitive sample preparation, which involves analytes extraction using QuEChERS, extract cleanup by dispersive-solid phase extraction with primary and secondary amine and C18 sorbents, and PAHs enrichment in the final extract using DLLME combined with ultra-low temperature (¿80°C). This cleanup contributed to a removal of 80% of matrix co-extractives. Acrylamide and 4-hydroxy-2,5-dimethyl-3(2H)-furanone were simultaneous analyzed using HPLC-MS, whose solid-phase extraction in cartridges resulted in the removal of potential analytical interference, with same transition m/z 72>55 monitored for acrylamide, without affecting accuracy and analytical sensibility of final method. Other compound formed during heat processing, 5-hydroxymethylfurfural, was investigated in baby foods using HPLC with diode array detection, after fast extraction with acetonitrile and subsequent dilution of extracts in order to minimize matrix effects. Acetonitrile-based extraction was used also to analyze 7 phthalates in baby foods employing GC-MS, whose extract cleanup was achieved with low-temperature purification (¿18°C), which demonstrated to be an efficient cleanup technique with reduction of 50% of total matrix co-extractives content. The first data about polyamines in baby foods were reported, for this, ion-pair extraction with bis(2-ethylhexyl)phosphate followed by microwave-assisted derivatization with heptafluorobutyric anhydride was optimized using factorial design associated to reponse surface analysis. The application of the developed analytical methods to commercial fruit-based baby food samples… Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Godoy, Helena Teixeira, 1957- (advisor), Universidade Estadual de Campinas. Faculdade de Tecnologia de Alimentos (institution), Programa de Pós-Graduação em Ciência de Alimentos (nameofprogram), Schroder, Claudia Hoffmann Kowalski (committee member), Rodrigues, Marili Villa Nova (committee member), Furlani, Regina Prado Zanes (committee member), Tfouni, Silvia Amelia Verdiani (committee member).

Subjects/Keywords: Acrilamida; Hidrocarbonetos policiclicos aromaticos; Agrotóxicos; Poliaminas; Ftalatos; Acrylamide; Polycyclic aromatic hydrocarbons; Polyamines; Pesticides; Phthalates

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Petrarca, Mateus Henrique, 1. (2017). Residues and contaminants in baby foods : development and validation of analytical methods = Resíduos e contaminantes em alimentos infantis: desenvolvimento e validação de métodos analíticos: Resíduos e contaminantes em alimentos infantis : desenvolvimento e validação de métodos analíticos. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/332308

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Petrarca, Mateus Henrique, 1983-. “Residues and contaminants in baby foods : development and validation of analytical methods = Resíduos e contaminantes em alimentos infantis: desenvolvimento e validação de métodos analíticos: Resíduos e contaminantes em alimentos infantis : desenvolvimento e validação de métodos analíticos.” 2017. Thesis, Universidade Estadual de Campinas. Accessed January 18, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/332308.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Petrarca, Mateus Henrique, 1983-. “Residues and contaminants in baby foods : development and validation of analytical methods = Resíduos e contaminantes em alimentos infantis: desenvolvimento e validação de métodos analíticos: Resíduos e contaminantes em alimentos infantis : desenvolvimento e validação de métodos analíticos.” 2017. Web. 18 Jan 2021.

Vancouver:

Petrarca, Mateus Henrique 1. Residues and contaminants in baby foods : development and validation of analytical methods = Resíduos e contaminantes em alimentos infantis: desenvolvimento e validação de métodos analíticos: Resíduos e contaminantes em alimentos infantis : desenvolvimento e validação de métodos analíticos. [Internet] [Thesis]. Universidade Estadual de Campinas; 2017. [cited 2021 Jan 18]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332308.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Petrarca, Mateus Henrique 1. Residues and contaminants in baby foods : development and validation of analytical methods = Resíduos e contaminantes em alimentos infantis: desenvolvimento e validação de métodos analíticos: Resíduos e contaminantes em alimentos infantis : desenvolvimento e validação de métodos analíticos. [Thesis]. Universidade Estadual de Campinas; 2017. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332308

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Berkeley

19. Berger, Kimberly. In utero exposure to personal care product and plasticizing chemicals and childhood immune dysfunction.

Degree: Epidemiology, 2018, University of California – Berkeley

URL: http://www.escholarship.org/uc/item/8g93p2fx

► Recent studies suggest that phthalates, parabens, and other phenols found in personal care products and plastics may be related to immunologic diseases. This dissertation focuses… (more)

▼ Recent studies suggest that phthalates, parabens, and other phenols found in personal care products and plastics may be related to immunologic diseases. This dissertation focuses on in utero exposure to these chemicals and the development of asthma, aeroallergies, and eczema in childhood, as well as lung function and relative concentrations of immune system biomarkers in childhood. We explored measurements of immune system functioning and atopic disease in children in the Center for the Health Assessment of Mothers and Children in Salinas (CHAMACOS) study, a prospective cohort of pregnant women and their children, from age six months to seven years and describes data collection and data consistency across ages. We determined classifications of cases of probable asthma, aeroallergies, and eczema at age seven in this population and found that, at age seven, 36 children out of 353 with relevant data (10%) had probable asthma, 87 children of 339 with relevant data (26%) had aeroallergies, and 23 children of 338 with relevant data (7%) had eczema. Lung function measurements were similar to national averages, and cytokine measurements changed with age in expected patterns.We analyzed associations of prenatal urinary concentrations of high molecular weight phthalates and bisphenol A, commonly found in some plastics, with probable asthma, aeroallergies, eczema, and spirometry at age seven, and with blood cytokine measurements at ages two, five, and seven. Logistic and linear regressions were conducted for 392 children, and Bayesian Model Averaging (BMA) was used to identify a select number of additional personal care product and plasticizing chemicals to be controlled for in the models, in order to account for confounding by joint chemical exposure to all phthalates, parabens, and phenols studied in this dissertation. We found that concentrations of monocarboxyisooctyl phthalate (MCOP) were associated with increased odds of having probable asthma (OR: 1.54, 95% CI: 1.12, 2.12) and poorer lung function (RR for forced expiratory volume in one second [FEV1]: -0.09, 95% CI: -0.15, -0.03; RR for forced expiratory flow from 25–75% of FVC [FEF25-75%]: -6.98, 95% CI: -10.95, -2.84). MCOP (OR: 1.28, 95% CI: 1.02, 1.62), MCPP (OR: 1.36, 95% CI: 1.07, 1.73), and BPA (OR: 1.35, 95% CI: 1.06, 1.73) were associated with aeroallergies, in crude models and models adjusting for demographic factors, but not in models adjusting further for additional chemical concentrations.We also examined associations between prenatal urinary concentrations of low molecular weight phthalates, parabens, triclosan, 2,4-dichlorophenol, 2,5-dichlorophenol, and benzophenone-3, all commonly found in personal care products, and the outcomes described above. Similar methods were used, including selection of additional chemical covariates using BMA. We found that concentrations of propyl paraben (OR: 0.84, 95% CI: 0.73, 0.97) and 2,5-dichlorophenol (OR: 0.63, 95% CI: 0.47, 0.86) were associated with decreased odds of having probable asthma. We also found that…

Subjects/Keywords: Epidemiology; Environmental health; Public health; Allergies; Asthma; Chemical mixtures; Cytokines; Personal care products; Phthalates

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Berger, K. (2018). In utero exposure to personal care product and plasticizing chemicals and childhood immune dysfunction. (Thesis). University of California – Berkeley. Retrieved from http://www.escholarship.org/uc/item/8g93p2fx

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Berger, Kimberly. “In utero exposure to personal care product and plasticizing chemicals and childhood immune dysfunction.” 2018. Thesis, University of California – Berkeley. Accessed January 18, 2021. http://www.escholarship.org/uc/item/8g93p2fx.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Berger, Kimberly. “In utero exposure to personal care product and plasticizing chemicals and childhood immune dysfunction.” 2018. Web. 18 Jan 2021.

Vancouver:

Berger K. In utero exposure to personal care product and plasticizing chemicals and childhood immune dysfunction. [Internet] [Thesis]. University of California – Berkeley; 2018. [cited 2021 Jan 18]. Available from: http://www.escholarship.org/uc/item/8g93p2fx.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Berger K. In utero exposure to personal care product and plasticizing chemicals and childhood immune dysfunction. [Thesis]. University of California – Berkeley; 2018. Available from: http://www.escholarship.org/uc/item/8g93p2fx

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Harvard University

20. Nassan Tawadros, Feiby Laban. Endocrine Disrupting Chemicals and Male Reproductive Health.

Degree: Doctor of Science (SD), 2017, Harvard University

URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42066970

►

Phthalates and parabens are endocrine disrupting chemicals with ubiquitous human exposure. Medication coatings and personal care products (PCPs) are important exposure sources, however, their contribution… (more)

▼

Phthalates and parabens are endocrine disrupting chemicals with ubiquitous human exposure. Medication coatings and personal care products (PCPs) are important exposure sources, however, their contribution to men’s exposure as well as health effects are understudied. Dibutyl phthalate (DBP) is used in some medication coatings e.g., mesalamine to treat inflammatory bowel disease. This work presents novel innovative methods to assess whether high-DBP exposure from mesalamine (>1000x background-exposure) altered serum reproductive hormones and semen quality. We took advantage of different mesalamine formulations with/without DBP to conduct a prospective crossover-crossback study (MARS study). We estimated crossover, crossback and carryover effects using multivariable linear mixed effect models. We conclude that high-DBP exposure disrupted serum levels of pituitary-gonadal hormone levels that largely reversed after exposure removal, but only in men with no/short history (< 3 years) of previous high-DBP exposure. However, high-DBP exposure among men with no history of high-DBP mesalamine use led to a reduction, primarily in sperm motility that was not reversed but became more pronounced (carried-over) after removal of exposure for four months. Paradoxically, among men with longer duration of high-DBP exposure, removal of the exposure did not change hormone levels or semen quality, suggesting that long-term high-DBP exposure may alter the pituitary-gonadal axis and spermatogenesis making them insensitive to DBP-exposure changes. Based on this work, we offer recommendations for designing future crossover-crossback studies including longer crossover-crossback durations and different timing of sample collection. In the prospective EARTH cohort study, we assessed PCPs’ contribution to men’s phthalate and paraben exposure. We estimated the changes in urinary concentrations associated with PCP-use using multivariable linear mixed and Tobit mixed regressions. We also estimated weights for each PCP in a weighted binary score regression and modeled the resulting composite weighted PCP-use. We identified ten PCPs of relevance and demonstrated that their use within six hours of urine collection strongly predicted specific phthalate and paraben urinary concentrations. We also offer concise PCP-use information by only asking specific questions about the use of the most relevant PCPs to help future research in decreasing missingness, improving recall, and decreasing misclassification while optimizing research cost and time.

Environmental Health

Advisors/Committee Members: Hauser, Russ (advisor), Coull, Brent A. (committee member), Skakkebaek, Niels E. (committee member), Williams, Michelle A. (committee member).

Subjects/Keywords: crossover; crossback; endocrine disruptors; epidemiology; hormones; men; parabens; phthalates; personal care products; semen parameters

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nassan Tawadros, F. L. (2017). Endocrine Disrupting Chemicals and Male Reproductive Health. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:42066970

Chicago Manual of Style (16^th Edition):

Nassan Tawadros, Feiby Laban. “Endocrine Disrupting Chemicals and Male Reproductive Health.” 2017. Doctoral Dissertation, Harvard University. Accessed January 18, 2021. http://nrs.harvard.edu/urn-3:HUL.InstRepos:42066970.

MLA Handbook (7^th Edition):

Nassan Tawadros, Feiby Laban. “Endocrine Disrupting Chemicals and Male Reproductive Health.” 2017. Web. 18 Jan 2021.

Vancouver:

Nassan Tawadros FL. Endocrine Disrupting Chemicals and Male Reproductive Health. [Internet] [Doctoral dissertation]. Harvard University; 2017. [cited 2021 Jan 18]. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42066970.

Council of Science Editors:

Nassan Tawadros FL. Endocrine Disrupting Chemicals and Male Reproductive Health. [Doctoral Dissertation]. Harvard University; 2017. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42066970

21. Bergé, Alexandre. Identification des sources d’alkylphénols et de phtalates en milieu urbain : comparaison des rejets à dominante urbaine (domestique) par rapport à des rejets purement industriels : Identification of the sources of alkylphénols and phtalates in urban zones : comparison of the discharges to urban dominant (domestic and home-made) with regard to purely industrial discharges.

Degree: Docteur es, Sciences de l'Univers et Environnement, 2012, Université Paris-Est

URL: http://www.theses.fr/2012PEST1113

► Les phtalates et les alkylphénols sont des composés organiques générés par l'industrie chimique, qui entrent dans la composition des matières plastiques, pour les phtalates, et… (more)

▼ Les phtalates et les alkylphénols sont des composés organiques générés par l'industrie chimique, qui entrent dans la composition des matières plastiques, pour les phtalates, et des détergents, pour les alkylphénols. Leurs productions mondiales avoisinent les 6 millions de tonnes pour les phtalates et 500 000 tonnes pour les alkylphénols. Ces composés sont considérés comme ubiquitaires dans l'environnement, c'est-à-dire qu'ils sont retrouvés dans tous les compartiments environnementaux (de l'atmosphère au milieu naturel). Par ailleurs, ils sont considérés comme des perturbateurs endocriniens et peuvent donc causer des dommages aux faunes et flores présentes dans le milieu naturel. Ce travail de thèse a permis de déterminer les niveaux de contamination des eaux usées en phtalates et alkylphénols dans plusieurs compartiments environnementaux situés en zone urbaine. Ainsi, des prélèvements effectués, par temps sec, ont permis de déterminer la qualité des eaux brutes vis-à-vis des paramètres globaux, des phtalates et des alkylphénols dans les rejets industriels, domestiques, les émissaires parisiens ainsi que dans les eaux usées transitant au sein d'une station d'épuration majeure d'Ile-de-France (Seine Centre, Colombes, 92). Ces résultats reflètent certaines spécificités et disparités du réseau d'assainissement, notamment marqués par la forte variabilité qui entoure, à la fois, le prélèvement et les niveaux de contamination par ces micropolluants. Au niveau des rejets industriels, de forts contrastes ont été observés entre les différents secteurs répertoriés (traitement des textiles, traitement de surface, métallurgie, industries pharmaceutiques, etc.). Globalement, les résultats des flux par équivalent-habitant soulignent que les apports domestiques sont la première source de contamination pour ces polluants en région parisienne. En effet, la contribution des apports industriels est inférieure à 5 %, pour tous les composés, quelque soit le secteur industriel considéré. L'étude des émissaires parisiens a permis de montrer une certaine stabilité temporelle de la qualité des effluents dans la partie avale du réseau d'assainissement. En revanche, cette étude a également mis en exergue des divergences et des similitudes entre les sous-bassins versants drainés par les différents émissaires. Ainsi, une étude statistique a montré que les émissaires Saint Denis Achères et Clichy Achères Argenteuil apparaissent significativement plus contaminés que les émissaires Sèvres Achères Reuil et Clichy Achères Bezons. Au niveau de l'efficacité des ouvrages de traitement, les résultats obtenus pour la station d'épuration de Seine Centre ont confirmé son efficacité pour les paramètres globaux communément utilisés pour déterminer la qualité des eaux usées. D'autre part, les résultats obtenus sur l'abattement des phtalates et des alkylphénols (rendements supérieurs à 83 % pour tous les composés) soulignent que même si les stations d'épuration ne sont, initialement, pas construites pour réduire et/ou éliminer les micropolluants, elles y… Advisors/Committee Members: Moilleron, Régis (thesis director).

Subjects/Keywords: Alkylphénols; Phtalates; Rejets industriels; Rejets domestiques; Eaux pluviales; Alkylphenols; Phthalates; Industrial wastewaters; Residential wastewaters; Rainwater

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bergé, A. (2012). Identification des sources d’alkylphénols et de phtalates en milieu urbain : comparaison des rejets à dominante urbaine (domestique) par rapport à des rejets purement industriels : Identification of the sources of alkylphénols and phtalates in urban zones : comparison of the discharges to urban dominant (domestic and home-made) with regard to purely industrial discharges. (Doctoral Dissertation). Université Paris-Est. Retrieved from http://www.theses.fr/2012PEST1113

Chicago Manual of Style (16^th Edition):

Bergé, Alexandre. “Identification des sources d’alkylphénols et de phtalates en milieu urbain : comparaison des rejets à dominante urbaine (domestique) par rapport à des rejets purement industriels : Identification of the sources of alkylphénols and phtalates in urban zones : comparison of the discharges to urban dominant (domestic and home-made) with regard to purely industrial discharges.” 2012. Doctoral Dissertation, Université Paris-Est. Accessed January 18, 2021. http://www.theses.fr/2012PEST1113.

MLA Handbook (7^th Edition):

Bergé, Alexandre. “Identification des sources d’alkylphénols et de phtalates en milieu urbain : comparaison des rejets à dominante urbaine (domestique) par rapport à des rejets purement industriels : Identification of the sources of alkylphénols and phtalates in urban zones : comparison of the discharges to urban dominant (domestic and home-made) with regard to purely industrial discharges.” 2012. Web. 18 Jan 2021.

Vancouver:

Bergé A. Identification des sources d’alkylphénols et de phtalates en milieu urbain : comparaison des rejets à dominante urbaine (domestique) par rapport à des rejets purement industriels : Identification of the sources of alkylphénols and phtalates in urban zones : comparison of the discharges to urban dominant (domestic and home-made) with regard to purely industrial discharges. [Internet] [Doctoral dissertation]. Université Paris-Est; 2012. [cited 2021 Jan 18]. Available from: http://www.theses.fr/2012PEST1113.

Council of Science Editors:

Bergé A. Identification des sources d’alkylphénols et de phtalates en milieu urbain : comparaison des rejets à dominante urbaine (domestique) par rapport à des rejets purement industriels : Identification of the sources of alkylphénols and phtalates in urban zones : comparison of the discharges to urban dominant (domestic and home-made) with regard to purely industrial discharges. [Doctoral Dissertation]. Université Paris-Est; 2012. Available from: http://www.theses.fr/2012PEST1113

University of Adelaide

22. Bhatia, Harpreet. Effects of exposures to the plasticiser, di-n-butyl phthalate and the pharmaceutical, flutamide on the biomarkers of reproduction in Australian freshwater fish species, Murray rainbowfish (Melanotaenia fluviatilis).

Degree: 2014, University of Adelaide

URL: http://hdl.handle.net/2440/93499

► With the detection of anti-androgenicity in the effluents from the wastewater treatment plants (WWTPs), there is speculation that sexual disruption in fish is a multi-causal… (more)

▼ With the detection of anti-androgenicity in the effluents from the wastewater treatment plants (WWTPs), there is speculation that sexual disruption in fish is a multi-causal condition involving anti-androgens. Much of the research has focussed on deciphering the modes-of-action (MoAs) of (anti)estrogens and androgens. However, effects of androgen receptor (AR) antagonists have not been fully characterised and remain elusive in fish. The present study aimed to investigate the effects of the classic mammalian anti-androgen, flutamide and the emerging industrial pollutant, di-n-butyl phthalate (DnBP) on the biomarkers of reproduction in adult (male and female) and juvenile Murray rainbowfish (Melanotaenia fluviatilis). Flutamide is the “pure” anti-androgen designed to treat prostate cancer in men and polycystic ovarian syndrome in women. It has also been extensively used in toxicity testing in mammals. The in vitro anti-androgenic activity in the aquatic environment worldwide is measured in flutamide equivalents. Phthalates are a class of synthetic industrial chemicals commonly found in the aquatic environment worldwide. They have been recognised as anti-androgens in male mammals but little is known about their endocrine-disrupting effects in the native Australian fish species. Due to its detection in freshwater both in Australia and worldwide and considering its higher solubility in water (11 mg/L), it is important to investigate effects of DnBP on the reproductive fitness of native Australian fish species. Flutamide is not an environmental contaminant and has not been detected in freshwater. However, it is used as the reference chemical to quantify antiandrogenic activity in aquatic environment using in vitro assays. In addition, flutamide is also used as the model anti-androgen to investigate anti-androgenic effects in mammals. Adult female and male Murray rainbowfish were exposed to biologically active concentrations (nominal 125 – 1000 μg/L) of flutamide for 7 days. In females, histological investigation revealed marked atresia and absence of mature oocytes in the flutamide-treated fish at all concentrations investigated. Reduction in the sizes of the vitellogenic oocytes was found after treatment with 500 and 1000 μg/L flutamide. The plasma VTG and the activity of brain aromatase were reduced in fish treated with 500 and 1000 μg/L flutamide. Treatment with 500 and 1000 μ/L flutamide reduced the concentrations of 11-keto testosterone (11-KT) and 17β-estradiol (E2) in plasma. In males, qualitative assessment of the testes of the fish exposed to 125 – 1000 μg/L flutamide exhibited inhibition in transformation of spermatogonia to spermatozoa and increased testicular anomalies like multinucleated and pyknotic cells and interstitial fibrosis. VTG was induced in plasma after an exposure to 1000 μg/L of flutamide. The activity of brain aromatase declined after exposure to flutamide at all concentrations. Males exposed to 1000 μg/L of flutamide showed a down-regulation of the hepatic genes encoding androgen receptors α… Advisors/Committee Members: Kumar, Anupama (advisor), McLaughlin, Michael John (advisor), Chapman, John (advisor), School of Agriculture, Food and Wine (school).

Subjects/Keywords: anti-androgens; phthalates; flutamide; fish; vitellogenin; aromatase; histology; receptors; reproduction; mixtures; mechanisms; hormones

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bhatia, H. (2014). Effects of exposures to the plasticiser, di-n-butyl phthalate and the pharmaceutical, flutamide on the biomarkers of reproduction in Australian freshwater fish species, Murray rainbowfish (Melanotaenia fluviatilis). (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/93499

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bhatia, Harpreet. “Effects of exposures to the plasticiser, di-n-butyl phthalate and the pharmaceutical, flutamide on the biomarkers of reproduction in Australian freshwater fish species, Murray rainbowfish (Melanotaenia fluviatilis).” 2014. Thesis, University of Adelaide. Accessed January 18, 2021. http://hdl.handle.net/2440/93499.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bhatia, Harpreet. “Effects of exposures to the plasticiser, di-n-butyl phthalate and the pharmaceutical, flutamide on the biomarkers of reproduction in Australian freshwater fish species, Murray rainbowfish (Melanotaenia fluviatilis).” 2014. Web. 18 Jan 2021.

Vancouver:

Bhatia H. Effects of exposures to the plasticiser, di-n-butyl phthalate and the pharmaceutical, flutamide on the biomarkers of reproduction in Australian freshwater fish species, Murray rainbowfish (Melanotaenia fluviatilis). [Internet] [Thesis]. University of Adelaide; 2014. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2440/93499.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bhatia H. Effects of exposures to the plasticiser, di-n-butyl phthalate and the pharmaceutical, flutamide on the biomarkers of reproduction in Australian freshwater fish species, Murray rainbowfish (Melanotaenia fluviatilis). [Thesis]. University of Adelaide; 2014. Available from: http://hdl.handle.net/2440/93499

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Washington

23. Shaffer, Rachel M. Maternal Urinary Phthalates in Relation to Gestational Diabetes and Glucose Intolerance During Pregnancy.

Degree: 2018, University of Washington

URL: http://hdl.handle.net/1773/42314

► Recent studies have linked phthalates with type 2 diabetes, but limited research exists on the potential association between phthalates and gestational diabetes (GDM), impaired glucose… (more)

Subjects/Keywords: Diabetes; Endocrine Disruption; Maternal Health; Phthalates; Pregnancy; Epidemiology; Public health; Environmental health; Environmental health

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shaffer, R. M. (2018). Maternal Urinary Phthalates in Relation to Gestational Diabetes and Glucose Intolerance During Pregnancy. (Thesis). University of Washington. Retrieved from http://hdl.handle.net/1773/42314

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shaffer, Rachel M. “Maternal Urinary Phthalates in Relation to Gestational Diabetes and Glucose Intolerance During Pregnancy.” 2018. Thesis, University of Washington. Accessed January 18, 2021. http://hdl.handle.net/1773/42314.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shaffer, Rachel M. “Maternal Urinary Phthalates in Relation to Gestational Diabetes and Glucose Intolerance During Pregnancy.” 2018. Web. 18 Jan 2021.

Vancouver:

Shaffer RM. Maternal Urinary Phthalates in Relation to Gestational Diabetes and Glucose Intolerance During Pregnancy. [Internet] [Thesis]. University of Washington; 2018. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1773/42314.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shaffer RM. Maternal Urinary Phthalates in Relation to Gestational Diabetes and Glucose Intolerance During Pregnancy. [Thesis]. University of Washington; 2018. Available from: http://hdl.handle.net/1773/42314

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of the Western Cape

24. Matinise, Nolubabalo. Electrolytic determination of phthalates organic pollutants with n nostructured titanium and iron oxides sensors .

Degree: 2010, University of the Western Cape

URL: http://hdl.handle.net/11394/2032

► This work reports the chemical synthesis, characterisation and electrochemical application of titanium dioxide (TiO2) and iron oxide (Fe2O3) nanoparticles in the determination of phthalates. The… (more)

Subjects/Keywords: Electrochemical sensor; Titanium dioxide nanoparticles; Iron oxide nanoparticles; Polymer nanocomposites; Phthalates; Dibutyl phthalates; Dioctyl phthalates; Diethylhexyl phthalates; Endocrine disruptors; Organic pollutants; Glassy Carbon Electrode; Voltammetry; Impedance

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Matinise, N. (2010). Electrolytic determination of phthalates organic pollutants with n nostructured titanium and iron oxides sensors . (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/2032

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Matinise, Nolubabalo. “Electrolytic determination of phthalates organic pollutants with n nostructured titanium and iron oxides sensors .” 2010. Thesis, University of the Western Cape. Accessed January 18, 2021. http://hdl.handle.net/11394/2032.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Matinise, Nolubabalo. “Electrolytic determination of phthalates organic pollutants with n nostructured titanium and iron oxides sensors .” 2010. Web. 18 Jan 2021.

Vancouver:

Matinise N. Electrolytic determination of phthalates organic pollutants with n nostructured titanium and iron oxides sensors . [Internet] [Thesis]. University of the Western Cape; 2010. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/11394/2032.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Matinise N. Electrolytic determination of phthalates organic pollutants with n nostructured titanium and iron oxides sensors . [Thesis]. University of the Western Cape; 2010. Available from: http://hdl.handle.net/11394/2032

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

25. Paluselli, Andrea. Analysis, occurence, release and degradation of phthalate esters (PAEs) in Mediterranean coastal sea : Analyse, distribution, production et dégradation d’esters de phtalates (PAEs) en zone côtière méditerranéenne.

Degree: Docteur es, Océanographie, 2018, Aix Marseille Université

URL: http://www.theses.fr/2018AIXM0060

►

Les phtalates (PAEs) sont un groupe de contaminants organiques émergents qui sont devenus une préoccupation majeure en raison de leur omniprésence dans le milieu marin… (more)

▼

Les phtalates (PAEs) sont un groupe de contaminants organiques émergents qui sont devenus une préoccupation majeure en raison de leur omniprésence dans le milieu marin et de leurs effets perturbateurs sur le système endocrinien. Cependant, leur répartition en Méditerranée est assez mal connue, principalement en raison des difficultés analytiques et du risque élevé de contamination des échantillons lors du processus analytique. En outre, les débris de plastique en milieu marin contiennent des additifs comme les PAEs, qui sont ajoutés lors de l’étape de fabrication du plastique. Dans la première partie de cette thèse, une méthode analytique a été optimisée et validée pour la détermination de 8 PAEs à l'état de traces en milieu marin. Brièvement, 1L d'échantillon filtré est passé à travers des cartouches de verre contenant 200 mg d'Oasis HLB, puis élué à l’aide de 6mL d'acétate d'éthyle. Notre méthode donne des rendements d’extraction compris entre 95 et 115 % et des blancs acceptables. Dans un second temps, un suivi annuel de la contamination de la Baie de Marseille a été effectué de décembre 2013 à novembre 2014. Les résultats ont montré la présence de 7 PAEs, avec des concentrations totales variant de 130 à 1330 ng L-1. Dans la dernière partie de cette thèse, deux échantillons de plastique communs (sac de poubelle et gaine de câble électrique) ont été incubés dans de l'eau de mer naturelle dans des conditions contrôlées de laboratoire, de manière à évaluer la migration de PAEs depuis ces matériaux en fonction de différentes conditions environnementales comme la température, la présence de lumière, ou encore la présence de bactéries.

Phthalic Acid Esters (PAEs) are a group of emerging organic contaminants that have become a serious issue because of their ubiquitous presence on the marine environment worldwide and for the endocrine disrupting effects in animals and humans. However, little is known about their distribution in the Ocean, mainly because of analytical difficulties and the high possibility of ambient sample contamination. Plastic debris in marine environment includes resin pellets, macro- and microplastic fragments, and contains additives such as PAEs that might be released in the aquatic environment in unknown proportion. In our work, we improved an analytical method for the determination of 8 PAEs, at trace levels in marine and fresh waters. In the first part of the thesis, the method was validated for different seawater salinities and wastewater treatment plant outlet. By passing 1 L of sample through glass cartridges packed with 200 mg of Oasis HLB and eluted with 6 mL of ethyl acetate, the recoveries of 8 PAEs ranged from 95 to 115 % with acceptable blank values (below 0.4-4.0 % of the masses measured in different seawater samples). In a second part, PAE distribution in the Marseille Bay has been evaluated though a one-year monitoring from December 2013 to November 2014. The results showed the occurrence of six PAEs with total concentrations ranging from 130 to 1330 ng L-1. In the last part of this…

Advisors/Committee Members: Sempéré, Richard (thesis director), Galgani, François (thesis director).

Subjects/Keywords: Phtalates; Dehp; Eau de mer; Perturbateurs endocriniens; Microplastiques; Phthalates; Dehp; Seawater; Endocrine disruptors; Microplastics; 550

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Paluselli, A. (2018). Analysis, occurence, release and degradation of phthalate esters (PAEs) in Mediterranean coastal sea : Analyse, distribution, production et dégradation d’esters de phtalates (PAEs) en zone côtière méditerranéenne. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2018AIXM0060

Chicago Manual of Style (16^th Edition):

Paluselli, Andrea. “Analysis, occurence, release and degradation of phthalate esters (PAEs) in Mediterranean coastal sea : Analyse, distribution, production et dégradation d’esters de phtalates (PAEs) en zone côtière méditerranéenne.” 2018. Doctoral Dissertation, Aix Marseille Université. Accessed January 18, 2021. http://www.theses.fr/2018AIXM0060.

MLA Handbook (7^th Edition):

Paluselli, Andrea. “Analysis, occurence, release and degradation of phthalate esters (PAEs) in Mediterranean coastal sea : Analyse, distribution, production et dégradation d’esters de phtalates (PAEs) en zone côtière méditerranéenne.” 2018. Web. 18 Jan 2021.

Vancouver:

Paluselli A. Analysis, occurence, release and degradation of phthalate esters (PAEs) in Mediterranean coastal sea : Analyse, distribution, production et dégradation d’esters de phtalates (PAEs) en zone côtière méditerranéenne. [Internet] [Doctoral dissertation]. Aix Marseille Université 2018. [cited 2021 Jan 18]. Available from: http://www.theses.fr/2018AIXM0060.

Council of Science Editors:

Paluselli A. Analysis, occurence, release and degradation of phthalate esters (PAEs) in Mediterranean coastal sea : Analyse, distribution, production et dégradation d’esters de phtalates (PAEs) en zone côtière méditerranéenne. [Doctoral Dissertation]. Aix Marseille Université 2018. Available from: http://www.theses.fr/2018AIXM0060

26. Richardson, Kadeem Anthony. The effects of environmentally relevant toxicants on female reproduction and embryo development.

Degree: PhD, Animal Sciences, 2019, University of Illinois – Urbana-Champaign

URL: http://hdl.handle.net/2142/106206

► Becoming pregnant and carrying to term is undeniably a very complicated process. Unfortunately, reproductive failure is widespread among many women globally. There are a plethora… (more)

▼ Becoming pregnant and carrying to term is undeniably a very complicated process. Unfortunately, reproductive failure is widespread among many women globally. There are a plethora of problems that can lead to reproductive failure among women such as, but not limited to, sexually transmitted infections (STI), hormone imbalance, body weight, stress, alcohol, drug abuse, diets, and genetics. A novel culprit that is now associated with reproductive failure is exposure to endocrine disrupting chemicals (EDCs). These chemical compounds can interact with the endocrine systems in humans and animals by influencing hormone metabolism. EDCs can disrupt the synthesis, secretion, transport, binding, action, or elimination of hormones, including hormones that are responsible for behavior and fertility, resulting in severe consequences for the reproductive and endocrine systems. One group of EDCs which gained interest are phthalates. Phthalates are a family of chemicals that are colorless, odorless, have lipophilic properties, and low solubility in water. Phthalates are used as plasticizers and additives in a variety of products such as polyvinyl chloride (PVC), cosmetics, adhesives, flooring, and medical supplies. However, phthalates leach from these products and enter the environment. Animals and humans are exposed to a variety of phthalates daily due to high production and leaching of phthalates. Phthalates are classified as reproductive toxicants because have they been shown to impair normal reproduction function in males and females. However, studies have primarily focused on male reproduction. Studies have shown that phthalates are detected in both female reproductive organs and fluids. Measurable amounts of phthalates are present in human blood, urine, amniotic fluid, ovarian follicular fluid, breast milk, and umbilical cord blood. However, there is limited research on the effects of phthalates on the female reproduction system, including the uterus. Specifically, it is unknown if environmentally and occupationally relevant doses of phthalates affect uterine morphology and function. Also, there are limited studies on the effects of phthalates on preimplantation embryos. Of these studies, most have shown that exposure to a single phthalate such as Di (2-ethylhexyl) phthalate (DEHP) and other EDCs have adverse effects on proper embryo development. However, there are limited data on the effects of exposure to relevant phthalate mixtures on preimplantation embryos. In this dissertation, I first examined whether adult exposure to environmentally and occupationally relevant doses of di (2-ethylhexyl) phthalate (DEHP) for 30 days in vivo alters uterine function and morphology. To determine whether the uterus was affected, the morphology, cellular proliferation, uterine glands, and steroid hormone levels were analyzed after exposure to DEHP for 30 days. Uterine morphology was evaluated by measuring the thickness of the myometrial layers (inner and outer), luminal epithelium height, counting the number of glands and finding the… Advisors/Committee Members: Nowak, Romana A (advisor), Flaws, Jodi A (advisor), Nowak, Romana A (Committee Chair), Miller, David J (committee member), Qiao, Huanyu (committee member), Rubessa, Marcello (committee member).

Subjects/Keywords: Phthalates; Toxicants; Uterus; Embryos; DEHP

…Phthalates �� ….…. ��…...….2 1.2 Uterus �� ….. �� ......6 1.3… …which has gained increased interest is phthalates. Phthalates are a family of structurally… …x5D;. Although phthalates are useful and have low productions cost, they readily leach from… …products and can enter biological tissues. Due to high usage and human exposure, phthalates have… …widely utilized phthalates di-(2-ethylhexyl) phthalate (DEHP) is associated…

10 more images…

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APA (6^th Edition):

Richardson, K. A. (2019). The effects of environmentally relevant toxicants on female reproduction and embryo development. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/106206

Chicago Manual of Style (16^th Edition):

Richardson, Kadeem Anthony. “The effects of environmentally relevant toxicants on female reproduction and embryo development.” 2019. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed January 18, 2021. http://hdl.handle.net/2142/106206.

MLA Handbook (7^th Edition):

Richardson, Kadeem Anthony. “The effects of environmentally relevant toxicants on female reproduction and embryo development.” 2019. Web. 18 Jan 2021.

Vancouver:

Richardson KA. The effects of environmentally relevant toxicants on female reproduction and embryo development. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2019. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2142/106206.

Council of Science Editors:

Richardson KA. The effects of environmentally relevant toxicants on female reproduction and embryo development. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2019. Available from: http://hdl.handle.net/2142/106206

NSYSU

27. Chen, Peng-yu. Large Scale Screening of Plasticizers by Ambient Mass Spectrometry.

Degree: Master, Chemistry, 2015, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0616115-152958

► Ambient mass spectrometry ï¼AMSï¼ is known for its unique feature to perform analysis without sample pretreatment, and has been used for direct, rapid, and real-time… (more)

▼ Ambient mass spectrometry ï¼AMSï¼ is known for its unique feature to perform analysis without sample pretreatment, and has been used for direct, rapid, and real-time detection of chemical compounds. Techniques such as DESI, DART, and ELDI have been demonstrated to be useful for rapidly characterizing chemical and biological compounds. In this study, we have developed an ambient mass spectrometric technique known as thermal desorption electrospray ionization mass spectrometry ï¼TD-ESI/MSï¼. A direct metallic sampling probe was used to collect analytes from sample surfaces regardless of sample size or shape. Analytes were thermally desorbed, post-ionized by reacting with charged solvent species in an electrospray plume, and the ions were subsequently detected by the mass analyzer attached to the ion source. .The residual sample on the metallic probe is rapidly removed by burning the probe with a flame from a torch. The time required to complete an analysis was less than 15 seconds. In the first study, TD-ESI/MS was used to screen phthalates [ Dibutyl Phthalate ï¼DBPï¼, Dimethyl Phthalate ï¼DMPï¼, Di-octyl Phthalate ï¼DOPï¼, Diï¼2-ethylhexylï¼Phthalate ï¼DEHPï¼, Di-iso-nonyl Phthalate ï¼DINPï¼, Benzyl Butyl Phthalate ï¼BBPï¼, Di-isodecyl Phthalate ï¼DIDPï¼and Diethyl Phthalate ï¼DEPï¼ ] on the objects in two kindergartens. Approximately one thousand samples were collected, analyzed and the results were reported within two days. Sample collection was completed in approximately 3hrs, TD-ESI/MS analysis was completed in 10 hrs, and data organization and report writing took another 5 hrs. The results indicate that approximately 30% and 20% of the objects in the two kindergartens contain higher level of phthalates. The success in screening phthalates in all the objects found in the two kindergartens suggests that performing large scale screening of phthalates in the living environment is possible. In the second study, liquid-phase microextraction ï¼LPMEï¼ was coupled with an ambient ionization technique, known as thermal desorption electrospray ionization ï¼TD-ESIï¼ for rapid screening of veterinary drug residues in foods. The ambient TD-ESI ion source consisted of ï¼1ï¼a metal loop suspending 5 Î¼L of organic solvent was used for analyte extraction in liquids, ï¼2ï¼after equilibrium among analytes, sample solution, and extraction solvent was reached, a heating oven for desorbing analytes on the LPME probe.Preliminary results of LPME/TD-ESI/MS/ showed that reproducibility tests ï¼n=5ï¼ for 10 Âµg/mL of sulfonamidesï¼sulfamethazine, sulfamethoxazoleï¼ and Î²-agonists ï¼clenbuterol, salbutamol, terbutalineï¼ were less than 7.6 % and 10.2 %, respectively. The sensitivities of sulfamethazineï¼m/z 279ï¼ and clenbuterolï¼m/z 277ï¼improved,; where detection limits could be decreased as low as 1.0 Âµg/mL, and 0.1 Âµg/mL while using the LPME fiber as a sampling probe. Furthermore, the capacity of LPME/TD-ESI/MS for quantitative analysis was evaluated using milk, honey and pork blood spiked with spiked veterinary drugs. Excellent… Advisors/Committee Members: Ming-Tsang Wu (chair), Jen-Taie Shiea (committee member), Lee Maw-Rong (chair).

Subjects/Keywords: Veterinary drug; Phthalates; Liquid Phase Microextraction ï¼LPMEï¼; Ambient Mass Spectrometry ï¼AMSï¼; Thermal Desorption ï¼TDï¼

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APA (6^th Edition):

Chen, P. (2015). Large Scale Screening of Plasticizers by Ambient Mass Spectrometry. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0616115-152958

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chen, Peng-yu. “Large Scale Screening of Plasticizers by Ambient Mass Spectrometry.” 2015. Thesis, NSYSU. Accessed January 18, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0616115-152958.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chen, Peng-yu. “Large Scale Screening of Plasticizers by Ambient Mass Spectrometry.” 2015. Web. 18 Jan 2021.

Vancouver:

Chen P. Large Scale Screening of Plasticizers by Ambient Mass Spectrometry. [Internet] [Thesis]. NSYSU; 2015. [cited 2021 Jan 18]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0616115-152958.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chen P. Large Scale Screening of Plasticizers by Ambient Mass Spectrometry. [Thesis]. NSYSU; 2015. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0616115-152958

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht

28. Janssen, E.M. Environmental Contaminants & Obesity.

Degree: 2012, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/257424

► Obesity is a rising problem concerning the general health. Recently it is suggested that environmental chemicals are related to the onset or maintenance of obesity.… (more)

Subjects/Keywords: Obesity; environmental contaminants; EDCs; metabolic disorders; diabetes; bisphenol A; phthalates; brominated flame retardants; dioxins; perfluorinated compounds

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Janssen, E. M. (2012). Environmental Contaminants & Obesity. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/257424

Chicago Manual of Style (16^th Edition):

Janssen, E M. “Environmental Contaminants & Obesity.” 2012. Masters Thesis, Universiteit Utrecht. Accessed January 18, 2021. http://dspace.library.uu.nl:8080/handle/1874/257424.

MLA Handbook (7^th Edition):

Janssen, E M. “Environmental Contaminants & Obesity.” 2012. Web. 18 Jan 2021.

Vancouver:

Janssen EM. Environmental Contaminants & Obesity. [Internet] [Masters thesis]. Universiteit Utrecht; 2012. [cited 2021 Jan 18]. Available from: http://dspace.library.uu.nl:8080/handle/1874/257424.

Council of Science Editors:

Janssen EM. Environmental Contaminants & Obesity. [Masters Thesis]. Universiteit Utrecht; 2012. Available from: http://dspace.library.uu.nl:8080/handle/1874/257424

University of Michigan

29. Neier, Kari. Developmental Exposures to Phthalates and Phthalate Mixtures and Life-Course Metabolic Outcomes: Using a Mouse Model to Inform Human Studies and Elucidate Mechanisms.

Degree: PhD, Toxicology, 2019, University of Michigan

URL: http://hdl.handle.net/2027.42/151581

► Nearly 40 percent of US adults and 20 percent of US children are obese. Given obesity’s multiple dangerous comorbidities, this presents a significant concern for… (more)

▼ Nearly 40 percent of US adults and 20 percent of US children are obese. Given obesity’s multiple dangerous comorbidities, this presents a significant concern for public health. A growing body of evidence suggests that exposures to environmental chemicals may be contributing to the obesity epidemic. Such chemicals have been termed “obesogens” and among them are phthalates, endocrine disrupting chemicals (EDCs) that are present in food packaging, children’s toys, and personal care products. Exposures to phthalates during development have been linked to adverse metabolic health outcomes in both animal and human studies, but findings from human studies are less consistent. One possible reason is humans are co-exposed to many phthalates, and these mixture exposures are difficult to interpret. Additionally, the vast majority of animal studies to date have focused on examining metabolic impacts of diethylhexyl phthalate (DEHP), despite the recent introduction of newer phthalates on the market to replace it, including diisononyl phthalate (DINP). Furthermore, mechanisms linking developmental exposures and later-life health outcomes, such as epigenetic reprogramming via DNA methylation, are still poorly understood. The overall objective of this dissertation was to utilize an animal model of perinatal phthalate exposures to investigate long-term metabolic impacts in a manner that would inform human studies and infer underlying mechanisms. We incorporated exposures to three individual phthalates (DEHP, DINP, and dibutyl phthalate (DBP)), as well as two phthalate mixtures (DEHP+DINP and DEHP+DINP+DBP). We then took phenotypic and molecular measurements on the offspring at two time points: at weaning on postnatal day 21 (PND21) at the end of the exposure period and at 10 months of age, >9 months after exposure had ceased. In Aim 1, we investigated early-life metabolic phenotypes by measuring body weight and relative liver weights and examined biomarkers of whole-genome DNA methylation alterations at PND21. In Aim 2, we evaluated metabolic phenotypes longitudinally at two and eight months of age to determine whether developmental exposures to phthalates influenced metabolism across the life course. Finally, in Aim 3, we measured the transcriptome and DNA methylation in liver and white adipose tissue (WAT) at both PND21 and 10 months to elucidate a molecular mechanism. We found that developmental exposures to individual phthalates and phthalate mixtures were associated with increased body weights in males and females in early postnatal life. Females, but not males, perinatally exposed to DINP-only and a mixture of DEHP+DINP also had increased relative liver weights at PND21. We also observed a sex-specific effect on tail DNA methylation at repetitive elements in mice exposed to individual phthalates and phthalate mixtures, indicating a sexually dimorphic effect on the epigenome. Developmental exposures to DEHP-only and DINP-only resulted in increased body fat percentage and glucose intolerance, respectively, across the life… Advisors/Committee Members: Dolinoy, Dana (committee member), Sartor, Maureen (committee member), Harris, Craig (committee member), Pennathur, Subramaniam (committee member), Song, Peter Xuekun (committee member).

Subjects/Keywords: Endocrine Disrupting Chemicals; Phthalates; Obesity and Metabolic Syndrome; Epigenetics; Transcriptomics; Developmental Origins of Health and Disease; Public Health; Health Sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Neier, K. (2019). Developmental Exposures to Phthalates and Phthalate Mixtures and Life-Course Metabolic Outcomes: Using a Mouse Model to Inform Human Studies and Elucidate Mechanisms. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/151581

Chicago Manual of Style (16^th Edition):

Neier, Kari. “Developmental Exposures to Phthalates and Phthalate Mixtures and Life-Course Metabolic Outcomes: Using a Mouse Model to Inform Human Studies and Elucidate Mechanisms.” 2019. Doctoral Dissertation, University of Michigan. Accessed January 18, 2021. http://hdl.handle.net/2027.42/151581.

MLA Handbook (7^th Edition):

Neier, Kari. “Developmental Exposures to Phthalates and Phthalate Mixtures and Life-Course Metabolic Outcomes: Using a Mouse Model to Inform Human Studies and Elucidate Mechanisms.” 2019. Web. 18 Jan 2021.

Vancouver:

Neier K. Developmental Exposures to Phthalates and Phthalate Mixtures and Life-Course Metabolic Outcomes: Using a Mouse Model to Inform Human Studies and Elucidate Mechanisms. [Internet] [Doctoral dissertation]. University of Michigan; 2019. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2027.42/151581.

Council of Science Editors:

Neier K. Developmental Exposures to Phthalates and Phthalate Mixtures and Life-Course Metabolic Outcomes: Using a Mouse Model to Inform Human Studies and Elucidate Mechanisms. [Doctoral Dissertation]. University of Michigan; 2019. Available from: http://hdl.handle.net/2027.42/151581

Universidade Estadual de Campinas

30. Christante, Caroline Maria, 1987-. Estudos experimentais do efeito do di-n-butil ftalato e do mono-(2-etilhexil) ftalato sobre o desenvolvimento testicular de roedores : Experimental studies of the di-n-butyl phthalate and mono-(2-ethylhexyl) phthalate effect on testicular development in rodents: Experimental studies of the di-n-butyl phthalate and mono-(2-ethylhexyl) phthalate effect on testicular development in rodents.

Degree: 2017, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332359

► Abstract: Phthalate esters such as di-n-butyl phthalate (DBP), di-(2-ethylhexyl) phthalate (DEHP) and its active metabolite, mono-(2-ethylhexyl) phthalate (MEHP), may exert adverse effects on reproductive hormones… (more)

▼ Abstract: Phthalate esters such as di-n-butyl phthalate (DBP), di-(2-ethylhexyl) phthalate (DEHP) and its active metabolite, mono-(2-ethylhexyl) phthalate (MEHP), may exert adverse effects on reproductive hormones and on fetal/neonatal germ cells in a species-specific manner. On the other hand, the docosahexaenoic acid (DHA - 22:6 n-3), a long-chain polyunsaturated fatty acid (PUFA) abundantly found in oily fish sources, seems to be beneficial for testosterone production, spermatogenesis and sperm motility. It is also known that MEHP and DHA act on the same metabolic pathways involved in cholesterol/lipid synthesis but in antagonistic ways. Thus, the present study evaluated whether the maternal exposure to DBP interferes with the development of the Mongolian gerbil testis during the first six weeks of postnatal development. It evaluated the action of DHA alone or in combination with MEHP on the mouse fetal testis as well, using the organotypic culture. For this, testis of male gerbils born from control (C) or exposed pregnant mothers to mineral oil (O) or DBP (100 mg/kg from 8 to 23 days post conception) were checked at the ages of 1, 7, 14, 28, 35 and 42 days. It was also conducted in vitro analysis of mice testes at 13.5 days post-conception (dpc) cultured in medium only (controls), DHA (50µM), MEHP (20µM) or both (50µM DHA/20µM MEHP) for 24 or 72 hours. As demonstrated by our results, DBP impaired the density of mitotic figures at birth and the total number of gonocytes (NG) at 7 postnatal days, besides increasing steroidogenic activity at the end of the first week of life, in the gerbil. The mineral oil, on the other hand, decreased testosterone and raised estrogen plasmatic levels at 7 and 28 days, respectively. In vitro analisys indicated that MEHP did not change the NG. Nevertheless, DHA stimulated testosterone secretion after 72h. This lipid also induced a marked extravasation of gonocytes into the interstitial tissue, a pro-apoptotic effect of cell populations in the stroma of the gonad and morphological alterations in the testicular cords after 3 days of culture. In conclusion, the present indications provided by in vivo experiments demonstrated that the first week of the gerbil postnatal life is more sensitive to deleterious effects of phthalate on the number of germ cells and steroidogenesis. In vitro experiments, therefore, indicated that the testicular development, for the mouse, was impaired by expose to DHA, which induced degenerative alterations in the Sertoli cells, worsened when combined with MEHP Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Góes, Rejane Maira (advisor), Universidade Estadual de Campinas. Instituto de Biologia (institution), Programa de Pós-Graduação em Biologia Celular e Estrutural (nameofprogram), Carvalho, João Ernesto (committee member), Torsoni, Adriana Souza (committee member), Fernandez, Carla Dal Bianco (committee member), Teixeira, Taiza Stumpp (committee member).

Subjects/Keywords: Testículos; Células germinativas; Gerbilo da Mongolia; Ftalatos; Ácido docosahexaenoico; Testicles; Germ cells; Mongolian gerbil; Phthalates; Docosahexaenoic acid

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APA (6^th Edition):

Christante, Caroline Maria, 1. (2017). Estudos experimentais do efeito do di-n-butil ftalato e do mono-(2-etilhexil) ftalato sobre o desenvolvimento testicular de roedores : Experimental studies of the di-n-butyl phthalate and mono-(2-ethylhexyl) phthalate effect on testicular development in rodents: Experimental studies of the di-n-butyl phthalate and mono-(2-ethylhexyl) phthalate effect on testicular development in rodents. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/332359

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Christante, Caroline Maria, 1987-. “Estudos experimentais do efeito do di-n-butil ftalato e do mono-(2-etilhexil) ftalato sobre o desenvolvimento testicular de roedores : Experimental studies of the di-n-butyl phthalate and mono-(2-ethylhexyl) phthalate effect on testicular development in rodents: Experimental studies of the di-n-butyl phthalate and mono-(2-ethylhexyl) phthalate effect on testicular development in rodents.” 2017. Thesis, Universidade Estadual de Campinas. Accessed January 18, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/332359.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Christante, Caroline Maria, 1987-. “Estudos experimentais do efeito do di-n-butil ftalato e do mono-(2-etilhexil) ftalato sobre o desenvolvimento testicular de roedores : Experimental studies of the di-n-butyl phthalate and mono-(2-ethylhexyl) phthalate effect on testicular development in rodents: Experimental studies of the di-n-butyl phthalate and mono-(2-ethylhexyl) phthalate effect on testicular development in rodents.” 2017. Web. 18 Jan 2021.

Vancouver:

Christante, Caroline Maria 1. Estudos experimentais do efeito do di-n-butil ftalato e do mono-(2-etilhexil) ftalato sobre o desenvolvimento testicular de roedores : Experimental studies of the di-n-butyl phthalate and mono-(2-ethylhexyl) phthalate effect on testicular development in rodents: Experimental studies of the di-n-butyl phthalate and mono-(2-ethylhexyl) phthalate effect on testicular development in rodents. [Internet] [Thesis]. Universidade Estadual de Campinas; 2017. [cited 2021 Jan 18]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332359.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Christante, Caroline Maria 1. Estudos experimentais do efeito do di-n-butil ftalato e do mono-(2-etilhexil) ftalato sobre o desenvolvimento testicular de roedores : Experimental studies of the di-n-butyl phthalate and mono-(2-ethylhexyl) phthalate effect on testicular development in rodents: Experimental studies of the di-n-butyl phthalate and mono-(2-ethylhexyl) phthalate effect on testicular development in rodents. [Thesis]. Universidade Estadual de Campinas; 2017. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332359

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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