subject:(Photosensitization Biological)

Rutgers University

1. Dao, Vi Khanh, 1988-. Synergistic effect of chitosan on photosensitization of staphylococcus aureus and Escherichia coli O157:H7 by sodium copper chlorophyllin.

Degree: MS, Food Science, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/47348/

► Microbial photoinactivation is a sensitizing process where a photosensitizer inactivates microorganisms by generating reactive oxygen species in the presence of light. Sodium copper chlorophyllin (Na-Chl)… (more)

▼ Microbial photoinactivation is a sensitizing process where a photosensitizer inactivates microorganisms by generating reactive oxygen species in the presence of light. Sodium copper chlorophyllin (Na-Chl) is a green dye approved by the Food and Drug Administration as generally recognized as safe (GRAS) and commonly used in dry beverage mixes. Na-Chl is a hydrophilic anionic photosensitizer, which is known to be less effective than cationic photosensitizer due to repulsive electrostatic force with the negatively charged membrane of the bacterial cell. Chitosan is a positively-charged antimicrobial polysaccharide. In this study, we investigated the synergistic effect of chitosan on photosensitization of Staphylococcus aureus and Escherichia coli O157:H7 by sodium copper chlorophyllin. Bacterial suspension in sterile water was incubated with different concentrations of Na-Chl prior to illumination with LED light at 400 nm to identify optimal concentration of Na-Chl for photosensitization. To examine the synergistic effect of chitosan, three different concentrations of chitosan were tested with the identified optimal concentration of Na-Chl. Three sample groups were tested: concurrent incubation of chitosan and Na-Chl prior to illumination, sequential incubation of chitosan first followed by addition of Na-Chl prior to illumination, and sequential incubation of Na-Chl first followed by addition of chitosan prior to illumination. We found that, in the experiment with S. aureus, the concurrent incubation group had a slight increase in log reduction compared to photosensitizer alone, whereas the sequential incubation with chitosan first reduced the effectiveness of photosensitizer. Interestingly, the sequential incubation with Na-Chl first followed by chitosan resulted in a synergistic effect, with an additional reduction of two log cycles compared to the photosensitizer alone. However, photosensitization had negligible killing effect on E. coli O157:H7. The results indicate that the intracellular localization of photosensitizer is important for the effectiveness of photosensitization, and that the ratio between chitosan and Na-Chl along with the sequence of treatment is important for the effectiveness of the hurdle system. Further studies are necessary to improve the effectiveness of photosensitization on gram-negative bacteria. Advisors/Committee Members: Matthews, Karl R (chair), Ludescher, Richard D (internal member), Di, Rong (outside member).

Subjects/Keywords: Photosensitization, Biological; Staphylococcus aureus; Escherichia coli; Chitosan

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APA (6^th Edition):

Dao, Vi Khanh, 1. (2015). Synergistic effect of chitosan on photosensitization of staphylococcus aureus and Escherichia coli O157:H7 by sodium copper chlorophyllin. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/47348/

Chicago Manual of Style (16^th Edition):

Dao, Vi Khanh, 1988-. “Synergistic effect of chitosan on photosensitization of staphylococcus aureus and Escherichia coli O157:H7 by sodium copper chlorophyllin.” 2015. Masters Thesis, Rutgers University. Accessed January 18, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/47348/.

MLA Handbook (7^th Edition):

Dao, Vi Khanh, 1988-. “Synergistic effect of chitosan on photosensitization of staphylococcus aureus and Escherichia coli O157:H7 by sodium copper chlorophyllin.” 2015. Web. 18 Jan 2021.

Vancouver:

Dao, Vi Khanh 1. Synergistic effect of chitosan on photosensitization of staphylococcus aureus and Escherichia coli O157:H7 by sodium copper chlorophyllin. [Internet] [Masters thesis]. Rutgers University; 2015. [cited 2021 Jan 18]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/47348/.

Council of Science Editors:

Dao, Vi Khanh 1. Synergistic effect of chitosan on photosensitization of staphylococcus aureus and Escherichia coli O157:H7 by sodium copper chlorophyllin. [Masters Thesis]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/47348/

Columbia University

2. Fankhauser, Alison Mariko. Formation and Degradation of Secondary Organic Aerosol Material.

Degree: 2020, Columbia University

URL: https://doi.org/10.7916/d8-rkj0-6e60

► Atmospheric aerosols have strong influences on climate and air quality, yet many open questions about the extent of their impact remain. Secondary organic aerosol (SOA)… (more)

▼ Atmospheric aerosols have strong influences on climate and air quality, yet many open questions about the extent of their impact remain. Secondary organic aerosol (SOA) is of particular interest because it accounts for a significant portion of fine particulate mass. Furthermore SOA formation mechanisms, composition, optical properties, and lifetimes are not fully understood. This is due in part to the numerous and diverse organic precursors in the atmosphere. SOA formation and growth involves complex and varied chemical and physical processes, and despite substantial progress over the past decade, the SOA budget has not been closed. This work explores three distinct projects to address the sources and sinks of SOA in aqueous aerosol particles: 1) the extent of photoactivator chemistry under ambient conditions, a potential source of organic aerosol mass via direct oxidation of volatile organic compounds or generation of oxidants in the particle phase; 2) the speciation and formation rates of isoprene epoxydiol (IEPOX)-derived SOA using a multiphase, photochemical model, GAMMA; and 3) the effect of bacterial metabolism on organic aerosol content. This body of work yields an improved understanding of atmospheric aerosol chemistry, with implications for where best to apply future research efforts. A photochemical chamber was constructed to carry out photosensitization experiments at longer timescales than can typically be achieved with aerosol flow tube equipment in order to mimic conditions of the ambient atmosphere. Light-absorbing humic acid aerosols were exposed to gas-phase limonene in the presence of ultraviolet light. Contrary to previous experimental results, no particle growth was observed. This is explained by the difference in light intensity and limonene concentrations between the two setups. Calculations based on our experimental results under ambient conditions suggest that the photosensitizer chemistry of humic-like substances is not expected to form substantial aerosol mass. Modeling studies of IEPOX SOA formation and aging are conducted to gain insights into the reaction mechanism. Recent instrument development has shown that previous product distributions and corresponding mechanisms were significantly biased by thermal degradation from the measurement techniques. We utilize the current state of knowledge surrounding IEPOX SOA formation in an attempt to elucidate a unifying mechanism. However, model results suggest that significant gaps remain in our understanding of formation and aging processes, especially oligomerization. Finally, we consider microbial consumption of aerosol organics in the atmosphere. Observations of culturable cells in aqueous aerosols and cloud water suggest that they may be actively metabolizing aqueous media while they are airborne, which could have significant impacts on aerosol and cloud properties. Metabolic rates of cells cultured from atmospheric samples are incorporated into GAMMA. While there is a substantial decrease in the concentration of…

Subjects/Keywords: Atmospheric chemistry; Atmospheric aerosols; Photosensitization, Biological; Aerosols – Analysis; Chemical engineering

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APA (6^th Edition):

Fankhauser, A. M. (2020). Formation and Degradation of Secondary Organic Aerosol Material. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/d8-rkj0-6e60

Chicago Manual of Style (16^th Edition):

Fankhauser, Alison Mariko. “Formation and Degradation of Secondary Organic Aerosol Material.” 2020. Doctoral Dissertation, Columbia University. Accessed January 18, 2021. https://doi.org/10.7916/d8-rkj0-6e60.

MLA Handbook (7^th Edition):

Fankhauser, Alison Mariko. “Formation and Degradation of Secondary Organic Aerosol Material.” 2020. Web. 18 Jan 2021.

Vancouver:

Fankhauser AM. Formation and Degradation of Secondary Organic Aerosol Material. [Internet] [Doctoral dissertation]. Columbia University; 2020. [cited 2021 Jan 18]. Available from: https://doi.org/10.7916/d8-rkj0-6e60.

Council of Science Editors:

Fankhauser AM. Formation and Degradation of Secondary Organic Aerosol Material. [Doctoral Dissertation]. Columbia University; 2020. Available from: https://doi.org/10.7916/d8-rkj0-6e60

3. Ou, Ching-Nan. Photoinduced skin sensitizer-tRNA and -DNA interactions and their effects on biological activity.

Degree: Chemistry, 1977, Texas Tech University

URL: http://hdl.handle.net/2346/19945

Subjects/Keywords: Skin – Diseases; Biological; Photosensitization

…PHOTOINDUCED SKIN SENSITIZER-tRNA AND -DNA INTERACTIONS AND THEIR EFFECTS ON BIOLOGICAL… …of psoralens in various biological systems. The relationship between the chemical structure… …are required for biological activity. Additionally, it has been postulated that the… …double bonds of furocoumarin is the most likely mechanism for skin photosensitization (31… …x28;29, 30). 3 Statement of Problem Preliminary model studies of skin-photosensitization…

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APA (6^th Edition):

Ou, C. (1977). Photoinduced skin sensitizer-tRNA and -DNA interactions and their effects on biological activity. (Thesis). Texas Tech University. Retrieved from http://hdl.handle.net/2346/19945

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ou, Ching-Nan. “Photoinduced skin sensitizer-tRNA and -DNA interactions and their effects on biological activity.” 1977. Thesis, Texas Tech University. Accessed January 18, 2021. http://hdl.handle.net/2346/19945.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ou, Ching-Nan. “Photoinduced skin sensitizer-tRNA and -DNA interactions and their effects on biological activity.” 1977. Web. 18 Jan 2021.

Vancouver:

Ou C. Photoinduced skin sensitizer-tRNA and -DNA interactions and their effects on biological activity. [Internet] [Thesis]. Texas Tech University; 1977. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2346/19945.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ou C. Photoinduced skin sensitizer-tRNA and -DNA interactions and their effects on biological activity. [Thesis]. Texas Tech University; 1977. Available from: http://hdl.handle.net/2346/19945

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas Tech University

4. Chang, Taek-hyoun. The ionic basis of the photosensory transduction in Stentor coeruleus.

Degree: Chemistry, 1982, Texas Tech University

URL: http://hdl.handle.net/2346/22180

Subjects/Keywords: Biological; Stentor coeruleus; Photosensitization; Photoreceptors

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APA (6^th Edition):

Chang, T. (1982). The ionic basis of the photosensory transduction in Stentor coeruleus. (Thesis). Texas Tech University. Retrieved from http://hdl.handle.net/2346/22180

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chang, Taek-hyoun. “The ionic basis of the photosensory transduction in Stentor coeruleus.” 1982. Thesis, Texas Tech University. Accessed January 18, 2021. http://hdl.handle.net/2346/22180.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chang, Taek-hyoun. “The ionic basis of the photosensory transduction in Stentor coeruleus.” 1982. Web. 18 Jan 2021.

Vancouver:

Chang T. The ionic basis of the photosensory transduction in Stentor coeruleus. [Internet] [Thesis]. Texas Tech University; 1982. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2346/22180.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chang T. The ionic basis of the photosensory transduction in Stentor coeruleus. [Thesis]. Texas Tech University; 1982. Available from: http://hdl.handle.net/2346/22180

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of British Columbia

5. Downum, Kelsey. Photosensitizing thiophenes from the Tageteae.

Degree: PhD, Botany, 1981, University of British Columbia

URL: http://hdl.handle.net/2429/22735

► Two separate aspects involving the thiophenes of the Tageteae (Asteraceae) were investigated. The first concerned the distribution of four thiophenes in Tagetes patula L. which… (more)

▼ Two separate aspects involving the thiophenes of the Tageteae (Asteraceae) were investigated. The first concerned the distribution of four thiophenes in Tagetes patula L. which were examined by high pressure liquid chromatography (HPLC). The derivatives were found to be differentially distributed throughout hydroponically grown plants. The predominant thiophenes in roots were 5-(4-acetoxy-1-butenyl)-2,2'-bithienyl (BBT-OAc) and 5-(buten-3-ynyl)-2,2'-bithienyl (BBT). BBT-OAc was the main derivative in shoots, whereas 2,2':5',2''-terthienyl (alpha-T) was the major compound in flower petals. BBT and one unidentified compound were found to occur in leaf glands. The levels of BBT-OAc in shoots and BBT-OAc and BBT in roots increased over the life of the plant and reached a plateau following flowering. Alpha-T in roots and both alpha-T and BBT in shoots remained at low levels over the life of the plant while 5-(4-hydroxy-1-butenyl)-2,2'-bithienyl (BBT-OH) was found to be an minor component of roots or shoots. Fourteen species from four genera of the tribe Tageteae were also screened for the presence of thiophenes by HPLC. Representatives of Dyssodia, Porophyllum, and Tagetes all contained thiophenes, but none were detected in species of Pectis. The second part of this study concerned the photobiocidal effects of isolated thiophenes on Escherichia coli B which was used as a model biological system. Alpha-terthienyl (alpha-T), in the presence of UV-A irradiation (320nm-400nm), was found to be a Type II photosensitizer which required oxygen for the expression of biological activity. Scavenger studies with sodium azide and BHT suggested that both singlet oxygen and superoxide were generated by the photosensitized reaction. Cellular inactivation by alpha-T was sensitive to temperature and studies with recombination deficient mutants of E. coli K-12 did not indicate that damage to cellular DNA occurred. Proteins were found to be substantially affected by the photoactivated reaction. SDS-gel electrophoresis revealed that both cytoplasmic and membrane-associated proteins might be. crosslinked following treatment with alpha-T and UV-A.

Subjects/Keywords: Photosensitivity Disorders; Photosensitization, Biological; Thiophenes; Tageteae

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APA (6^th Edition):

Downum, K. (1981). Photosensitizing thiophenes from the Tageteae. (Doctoral Dissertation). University of British Columbia. Retrieved from http://hdl.handle.net/2429/22735

Chicago Manual of Style (16^th Edition):

Downum, Kelsey. “Photosensitizing thiophenes from the Tageteae.” 1981. Doctoral Dissertation, University of British Columbia. Accessed January 18, 2021. http://hdl.handle.net/2429/22735.

MLA Handbook (7^th Edition):

Downum, Kelsey. “Photosensitizing thiophenes from the Tageteae.” 1981. Web. 18 Jan 2021.

Vancouver:

Downum K. Photosensitizing thiophenes from the Tageteae. [Internet] [Doctoral dissertation]. University of British Columbia; 1981. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2429/22735.

Council of Science Editors:

Downum K. Photosensitizing thiophenes from the Tageteae. [Doctoral Dissertation]. University of British Columbia; 1981. Available from: http://hdl.handle.net/2429/22735

Rhodes University

6. Seotsanyana-Mokhosi, Itumeleng. Photosensitizing properties of non-transition metal porphyrazines towards the generation of singlet oxygen.

Degree: Faculty of Science, Chemistry, 2001, Rhodes University

URL: http://hdl.handle.net/10962/d1006086

►

Metallophthalocyanine complexes containing non-transition metals are very useful as sensitizers for photodynamic therapy, a cure for cancer that is based on visible light activation of… (more)

Subjects/Keywords: Phthalocyanines; Photosensitization, Biological; Active oxygen – Physiological effect; Photosensitizing compounds

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APA (6^th Edition):

Seotsanyana-Mokhosi, I. (2001). Photosensitizing properties of non-transition metal porphyrazines towards the generation of singlet oxygen. (Thesis). Rhodes University. Retrieved from http://hdl.handle.net/10962/d1006086

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Seotsanyana-Mokhosi, Itumeleng. “Photosensitizing properties of non-transition metal porphyrazines towards the generation of singlet oxygen.” 2001. Thesis, Rhodes University. Accessed January 18, 2021. http://hdl.handle.net/10962/d1006086.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Seotsanyana-Mokhosi, Itumeleng. “Photosensitizing properties of non-transition metal porphyrazines towards the generation of singlet oxygen.” 2001. Web. 18 Jan 2021.

Vancouver:

Seotsanyana-Mokhosi I. Photosensitizing properties of non-transition metal porphyrazines towards the generation of singlet oxygen. [Internet] [Thesis]. Rhodes University; 2001. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10962/d1006086.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Seotsanyana-Mokhosi I. Photosensitizing properties of non-transition metal porphyrazines towards the generation of singlet oxygen. [Thesis]. Rhodes University; 2001. Available from: http://hdl.handle.net/10962/d1006086

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

7. Cheng, Yuk-luen, Lydia. Effects of visible light on cells, subcellular organelles and enzymes.

Degree: 1979, University of Hong Kong

URL: http://hdl.handle.net/10722/34889

Subjects/Keywords: Cells.; Enzymes.; Light - Physiological effect.; Photosensitization, Biological.

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APA (6^th Edition):

Cheng, Yuk-luen, L. (1979). Effects of visible light on cells, subcellular organelles and enzymes. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/34889

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cheng, Yuk-luen, Lydia. “Effects of visible light on cells, subcellular organelles and enzymes.” 1979. Thesis, University of Hong Kong. Accessed January 18, 2021. http://hdl.handle.net/10722/34889.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cheng, Yuk-luen, Lydia. “Effects of visible light on cells, subcellular organelles and enzymes.” 1979. Web. 18 Jan 2021.

Vancouver:

Cheng, Yuk-luen L. Effects of visible light on cells, subcellular organelles and enzymes. [Internet] [Thesis]. University of Hong Kong; 1979. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10722/34889.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cheng, Yuk-luen L. Effects of visible light on cells, subcellular organelles and enzymes. [Thesis]. University of Hong Kong; 1979. Available from: http://hdl.handle.net/10722/34889

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Tech

8. Levenick, Clifford Keith. A study of the effect of environmental lighting on growth, reproduction and behavior in turkeys (Meleagris gallopavo).

Degree: PhD, Animal Science, 1977, Virginia Tech

URL: http://hdl.handle.net/10919/74158

► This study was designed to determine the effect of environmental lighting on growth, reproduction and behavior in turkeys. During the growth phase a Large White… (more)

▼ This study was designed to determine the effect of environmental lighting on growth, reproduction and behavior in turkeys. During the growth phase a Large White and a Medium White line of turkeys were reared on an intermittent (2L:2D) or a diurnal (12L:l2D) light regimens under white, red (650 nm) or blue (450 nm) light environments. The turkeys grew faster under blue light than under red or white light up to 16 weeks of age. However, by 24 weeks of age, the rates of gain were significantly greater under the white and red lights. Growth rates were significantly greater under the intermittent regimen as compared to the diurnal regimen for both lines and sexes. The greatest acceleration in growth rate was observed from 4 to 10 weeks of age with this advantage still evident at 24 weeks of age. There were no significant differences in feed efficiency due to regimen or color. Early mortality was highest under blue light but late mortality was greater under red and white light. Mortality was higher for the LW than MW birds. Live grades were unaffected by light regimen or color but feather condition was poorest for birds reared under white diurnal regimen. The light color and regimen had no significant effect on the histological and physiological parameters measured. However, measurements of sexual development tended to be lower in both sexes for birds reared under blue light. Turkeys growing under the blue light regimens were the most placid while those reared under the white diurnal regimen were the most nervous. In the reproductive phase, medium white turkeys from each growth phase regimen and color combination were placed into white, red and blue light pens. Mating behavior measures were higher under red and white light than under blue light. In addition, rearing of turkeys under blue lights appeared to reduce sexual behavior in Experiment 2. For most mating behavior measures, the optimum light color combination appeared to be the white growth-white reproductive light program. While all mating behavior measures were continually lower for turkeys reared under intermittent light than those reared under a diurnal regimen, these differences were not significantly different. Turkeys exhibited two types of agonistic behavior. Fights between toms and hens occurred regularly in the blue reproductive light pens and rarely in the others. The majority of the fights occurred among hens and toms reared under red light. Toms from blue growth phase pens and subsequently placed in the red reproductive light environments, exhibited a super-aggressive behavior towards any human entering those pens. Egg production and semen volume measures were significantly greater for turkeys in the red and white reproductive pens than for those under the blue light conditions. The hens in the red and white growth pens came into egg production prematurely at 27 weeks of age when maintained on an intermittent light regimen during the growth phase.

Subjects/Keywords: LD5655.V856 1977.L495; Turkeys; Galliformes; Light – Physiological effect; Photosensitization, Biological

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APA (6^th Edition):

Levenick, C. K. (1977). A study of the effect of environmental lighting on growth, reproduction and behavior in turkeys (Meleagris gallopavo). (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/74158

Chicago Manual of Style (16^th Edition):

Levenick, Clifford Keith. “A study of the effect of environmental lighting on growth, reproduction and behavior in turkeys (Meleagris gallopavo).” 1977. Doctoral Dissertation, Virginia Tech. Accessed January 18, 2021. http://hdl.handle.net/10919/74158.

MLA Handbook (7^th Edition):

Levenick, Clifford Keith. “A study of the effect of environmental lighting on growth, reproduction and behavior in turkeys (Meleagris gallopavo).” 1977. Web. 18 Jan 2021.

Vancouver:

Levenick CK. A study of the effect of environmental lighting on growth, reproduction and behavior in turkeys (Meleagris gallopavo). [Internet] [Doctoral dissertation]. Virginia Tech; 1977. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10919/74158.

Council of Science Editors:

Levenick CK. A study of the effect of environmental lighting on growth, reproduction and behavior in turkeys (Meleagris gallopavo). [Doctoral Dissertation]. Virginia Tech; 1977. Available from: http://hdl.handle.net/10919/74158

University of New South Wales

9. Wittmann , Johannes. Phase I animal safety study of new second generation porphyrin based photosensitizers in the Syrian Golden hamster.

Degree: Clinical School - South Western Sydney, 2007, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/39833 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:4474/SOURCE02?view=true

► Pancreatic cancer kills over 1700 people each year in Australia. In 2000, there were1908 new cases diagnosed and it remains one of the least treatable… (more)

▼ Pancreatic cancer kills over 1700 people each year in Australia. In 2000, there were1908 new cases diagnosed and it remains one of the least treatable malignancies. Inthe USA, it was the fourth leading cause of cancer death in 2004, with 31,860 newcases and 31,270 recorded deaths. Photodynamic therapy (PDT) is a novel,potentially useful treatment for locally advanced pancreatic cancer with only limitedresearch and clinical work addressing this until now. PDT induces non-thermal,cytotoxic and ischaemic injury to a targeted volume of tissue. During PDT, aphotosensitizer is activated by non-thermal light in the presence of oxygen, generatingcytotoxic oxygen species and inducing cellular injury and microvascular occlusion.The aim of this thesis was to conduct an animal safety study using two secondgeneration photosensitizers, talaporfin sodium and verteporfin, to assess the risks ofpancreatic PDT by looking at injury to organs adjacent to the pancreas and assessingrecovery from PDT treatment of the pancreas. The Syrian Golden hamster animalmodel was used to compare the results of this research to previous work by otherauthors.The study design incorporated a number of additional experiments, includingquantitative tissue fluorescence techniques, plasma level analysis and histopathologytechniques. The methods for the animal safety study were similar to the approachused in the clinical setting and provided vital data on the likely risks and side effectsof phototherapy in humans.The first study, looking at talaporfin sodium, found likely risks of duodenal injury,gastric injury and death with a limited effect on normal pancreas at photosensitizerdoses likely to be employed for pancreatic cancer PDT. The second study, usingverteporfin, found similar results with a more potent effect on the normal pancreas atstudied drug doses. Both agents had short drug-light intervals, ranging from 15minutes to 2 hours, reducing the need for pre-treatment hospitalization and shortphotosensitivity periods of about one to two weeks. Some animals suffered minorcutaneous photosensitivity injuries. A human pancreatic cancer PDT pilot study isfeasible and the risks and complications should be acceptable. Advisors/Committee Members: Wilson, Jeremy S, Clinical School - South Western Sydney, Faculty of Medicine, UNSW.

Subjects/Keywords: Pancreatic cancer; Talaporfin; Verteporfin; Porphyrins; Hamsters as laboratory animals; Photosensitization, Biological – Congresses

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APA (6^th Edition):

Wittmann , J. (2007). Phase I animal safety study of new second generation porphyrin based photosensitizers in the Syrian Golden hamster. (Masters Thesis). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/39833 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:4474/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Wittmann , Johannes. “Phase I animal safety study of new second generation porphyrin based photosensitizers in the Syrian Golden hamster.” 2007. Masters Thesis, University of New South Wales. Accessed January 18, 2021. http://handle.unsw.edu.au/1959.4/39833 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:4474/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Wittmann , Johannes. “Phase I animal safety study of new second generation porphyrin based photosensitizers in the Syrian Golden hamster.” 2007. Web. 18 Jan 2021.

Vancouver:

Wittmann J. Phase I animal safety study of new second generation porphyrin based photosensitizers in the Syrian Golden hamster. [Internet] [Masters thesis]. University of New South Wales; 2007. [cited 2021 Jan 18]. Available from: http://handle.unsw.edu.au/1959.4/39833 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:4474/SOURCE02?view=true.

Council of Science Editors:

Wittmann J. Phase I animal safety study of new second generation porphyrin based photosensitizers in the Syrian Golden hamster. [Masters Thesis]. University of New South Wales; 2007. Available from: http://handle.unsw.edu.au/1959.4/39833 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:4474/SOURCE02?view=true

Georgia Tech

10. Roberts, Lezah Wilette. Effect of Netropsin on One-electron Oxidation of DNA.

Degree: PhD, Chemistry and Biochemistry, 2005, Georgia Tech

URL: http://hdl.handle.net/1853/7228

► One electron oxidation of DNA has been studied extensively over the years. When a charge is injected into a DNA duplex, it migrates through the… (more)

Subjects/Keywords: Photosensitizer; Charge transfer; Netropsin; TQ; DNA; Electron transfer; One-electron oxidation; Photosensitization, Biological; Charge transfer in biology; DNA Analysis; Oxidation, Physiological

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APA (6^th Edition):

Roberts, L. W. (2005). Effect of Netropsin on One-electron Oxidation of DNA. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/7228

Chicago Manual of Style (16^th Edition):

Roberts, Lezah Wilette. “Effect of Netropsin on One-electron Oxidation of DNA.” 2005. Doctoral Dissertation, Georgia Tech. Accessed January 18, 2021. http://hdl.handle.net/1853/7228.

MLA Handbook (7^th Edition):

Roberts, Lezah Wilette. “Effect of Netropsin on One-electron Oxidation of DNA.” 2005. Web. 18 Jan 2021.

Vancouver:

Roberts LW. Effect of Netropsin on One-electron Oxidation of DNA. [Internet] [Doctoral dissertation]. Georgia Tech; 2005. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1853/7228.

Council of Science Editors:

Roberts LW. Effect of Netropsin on One-electron Oxidation of DNA. [Doctoral Dissertation]. Georgia Tech; 2005. Available from: http://hdl.handle.net/1853/7228

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Open Access Theses and Dissertations