subject:(Phosphoprotein phosphatases)

Hong Kong University of Science and Technology

1. Huang, Huiqian LIFS. Role of liprinα1 in activity-dependent synapse development.

Degree: 2016, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-97101 ; https://doi.org/10.14711/thesis-b1585226 ; http://repository.ust.hk/ir/bitstream/1783.1-97101/1/th_redirect.html

► Neuronal activity plays an essential role in guiding synapse development, which underlies the experience-dependent shaping of brain circuitry. Synapse development requires the concerted regulation of… (more)

Subjects/Keywords: Synapses ; Growth ; Nerve growth factor ; Phosphoprotein phosphatases

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APA (6^th Edition):

Huang, H. L. (2016). Role of liprinα1 in activity-dependent synapse development. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-97101 ; https://doi.org/10.14711/thesis-b1585226 ; http://repository.ust.hk/ir/bitstream/1783.1-97101/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Huang, Huiqian LIFS. “Role of liprinα1 in activity-dependent synapse development.” 2016. Thesis, Hong Kong University of Science and Technology. Accessed April 15, 2021. http://repository.ust.hk/ir/Record/1783.1-97101 ; https://doi.org/10.14711/thesis-b1585226 ; http://repository.ust.hk/ir/bitstream/1783.1-97101/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Huang, Huiqian LIFS. “Role of liprinα1 in activity-dependent synapse development.” 2016. Web. 15 Apr 2021.

Vancouver:

Huang HL. Role of liprinα1 in activity-dependent synapse development. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2016. [cited 2021 Apr 15]. Available from: http://repository.ust.hk/ir/Record/1783.1-97101 ; https://doi.org/10.14711/thesis-b1585226 ; http://repository.ust.hk/ir/bitstream/1783.1-97101/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Huang HL. Role of liprinα1 in activity-dependent synapse development. [Thesis]. Hong Kong University of Science and Technology; 2016. Available from: http://repository.ust.hk/ir/Record/1783.1-97101 ; https://doi.org/10.14711/thesis-b1585226 ; http://repository.ust.hk/ir/bitstream/1783.1-97101/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

2. Clark, Catherine Renee. Regulation of Hepatic Glycogen Metabolism by Glycogen Targeting Subunits of Protein Phosphatase 1.

Degree: 2007, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/829

► Glycogen targeting subunits of protein phosphatase 1 play a critical role in fuel homeostasis through the regulation of glycogen metabolism. Adenovirus-mediated overexpression of the liver… (more)

Subjects/Keywords: Glucose; Liver Glycogen; Phosphoprotein Phosphatases

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APA (6^th Edition):

Clark, C. R. (2007). Regulation of Hepatic Glycogen Metabolism by Glycogen Targeting Subunits of Protein Phosphatase 1. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/829

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Clark, Catherine Renee. “Regulation of Hepatic Glycogen Metabolism by Glycogen Targeting Subunits of Protein Phosphatase 1.” 2007. Thesis, University of Texas Southwestern Medical Center. Accessed April 15, 2021. http://hdl.handle.net/2152.5/829.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Clark, Catherine Renee. “Regulation of Hepatic Glycogen Metabolism by Glycogen Targeting Subunits of Protein Phosphatase 1.” 2007. Web. 15 Apr 2021.

Vancouver:

Clark CR. Regulation of Hepatic Glycogen Metabolism by Glycogen Targeting Subunits of Protein Phosphatase 1. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2007. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/2152.5/829.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Clark CR. Regulation of Hepatic Glycogen Metabolism by Glycogen Targeting Subunits of Protein Phosphatase 1. [Thesis]. University of Texas Southwestern Medical Center; 2007. Available from: http://hdl.handle.net/2152.5/829

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

3. Bembenek, Joshua Nathaniel. CDC14 Coordinates Cyclin Destruction with the Onset of Cytokinesis.

Degree: 2004, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/556

► The Cdc14 family of protein phosphatases operate during the final stages of mitosis in various organisms. The Cdc14 phosphatases are downstream components of two homologous… (more)

▼ The Cdc14 family of protein phosphatases operate during the final stages of mitosis in various organisms. The Cdc14 phosphatases are downstream components of two homologous signaling pathways: the mitotic exit network (MEN) of S. cerevisiae and septation initiation network (SIN) of S. pombe. Studies of these pathways have revealed divergent roles of Cdc14. In the MEN pathway, Cdc14 is required for cyclin degradation by dephosphorylating Cdh1. The dephosphorylated form of Cdh1 binds to and activates a ubiquitin ligase known as the anaphase-promoting complex (APC/C), which then ubiquitinates mitotic cyclins, targeting them for degradation by the 26S proteosome. In contrast, Cdc14 of the SIN is dispensable for cyclin degradation, but plays an important role during cytokinesis. Two Cdc14 homologues are found in vertebrates, hCdc14A and hCdc14B. I have investigated the regulation of Cdc14 phosphatases to obtain insights into the mechanisms of mitotic exit in higher eukaryotes. Biochemical studies demonstrate that recombinant hCdc14A and hCdc14B can dephosphorylate human Cdh1 and stimulate APC/CCdh1 ligase activity in vitro. Since both the MEN and SIN pathways control Cdc14 localization, I have examined the regulation of the subcellular localization of hCdc14A, hCdc14B and the budding yeast Cdc14. In HeLa cells, hCdc14A localizes to the centrosome whereas hCdc14B is nucleolar during interphase. Both hCdc14 homologues localize to the centrosome and midbody during mitosis. In budding yeast, Cdc14p localizes to the nucleolus during most of the cell cycle and is released in late anaphase when it localizes to the centrosome and the bud neck. The subcellular localization the Cdc14 homologues in HeLa cells is regulated by a nuclear export signal. S. cerevisiae strains carrying only NES mutant CDC14 alleles are capable of degrading mitotic cyclins and escaping mitosis. However, they exhibit a temperature-sensitive phenotype at 37°C because they fail to complete cytokinesis and lack centrosome and bud neck localization of Cdc14. This demonstrates that the Cdc14 phosphatases are regulated by nucleocytoplasmic shuttling. Collectively, my work strongly suggests that the Cdc14 phosphatases play a conserved role in coordinating the destruction of mitotic cyclins with the execution of cytokinesis. Advisors/Committee Members: Yu, Hongtao.

Subjects/Keywords: Phosphoprotein Phosphatases; Cytokinesis; Signal Transduction

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APA (6^th Edition):

Bembenek, J. N. (2004). CDC14 Coordinates Cyclin Destruction with the Onset of Cytokinesis. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/556

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bembenek, Joshua Nathaniel. “CDC14 Coordinates Cyclin Destruction with the Onset of Cytokinesis.” 2004. Thesis, University of Texas Southwestern Medical Center. Accessed April 15, 2021. http://hdl.handle.net/2152.5/556.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bembenek, Joshua Nathaniel. “CDC14 Coordinates Cyclin Destruction with the Onset of Cytokinesis.” 2004. Web. 15 Apr 2021.

Vancouver:

Bembenek JN. CDC14 Coordinates Cyclin Destruction with the Onset of Cytokinesis. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2004. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/2152.5/556.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bembenek JN. CDC14 Coordinates Cyclin Destruction with the Onset of Cytokinesis. [Thesis]. University of Texas Southwestern Medical Center; 2004. Available from: http://hdl.handle.net/2152.5/556

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Hong Kong University of Science and Technology

4. Chan, Shing Fai. Association of the serine/threonine protein phosphatase 2A with the N-methyl-D-aspartate receptor subunit NR3A.

Degree: 1999, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-3858 ; https://doi.org/10.14711/thesis-b647129 ; http://repository.ust.hk/ir/bitstream/1783.1-3858/1/th_redirect.html

► The N-methyl-D-aspartic acid (NMDA) subclass of excitatory ionotropic glutamate receptors plays critical roles in neuronal development, plasticity and cell death. The NMDA receptors are thought… (more)

Subjects/Keywords: Methyl aspartate – Receptors ; Phosphoprotein phosphatases

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APA (6^th Edition):

Chan, S. F. (1999). Association of the serine/threonine protein phosphatase 2A with the N-methyl-D-aspartate receptor subunit NR3A. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-3858 ; https://doi.org/10.14711/thesis-b647129 ; http://repository.ust.hk/ir/bitstream/1783.1-3858/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chan, Shing Fai. “Association of the serine/threonine protein phosphatase 2A with the N-methyl-D-aspartate receptor subunit NR3A.” 1999. Thesis, Hong Kong University of Science and Technology. Accessed April 15, 2021. http://repository.ust.hk/ir/Record/1783.1-3858 ; https://doi.org/10.14711/thesis-b647129 ; http://repository.ust.hk/ir/bitstream/1783.1-3858/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chan, Shing Fai. “Association of the serine/threonine protein phosphatase 2A with the N-methyl-D-aspartate receptor subunit NR3A.” 1999. Web. 15 Apr 2021.

Vancouver:

Chan SF. Association of the serine/threonine protein phosphatase 2A with the N-methyl-D-aspartate receptor subunit NR3A. [Internet] [Thesis]. Hong Kong University of Science and Technology; 1999. [cited 2021 Apr 15]. Available from: http://repository.ust.hk/ir/Record/1783.1-3858 ; https://doi.org/10.14711/thesis-b647129 ; http://repository.ust.hk/ir/bitstream/1783.1-3858/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chan SF. Association of the serine/threonine protein phosphatase 2A with the N-methyl-D-aspartate receptor subunit NR3A. [Thesis]. Hong Kong University of Science and Technology; 1999. Available from: http://repository.ust.hk/ir/Record/1783.1-3858 ; https://doi.org/10.14711/thesis-b647129 ; http://repository.ust.hk/ir/bitstream/1783.1-3858/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

5. Pan, Ming-gui. Protein-tyrosine phosphatases : regulation of cell growth and differentiation.

Degree: PhD, 1993, Oregon Health Sciences University

URL: doi:10.6083/M4P55KQ3 ; http://digitalcommons.ohsu.edu/etd/2843

Subjects/Keywords: Protein-Tyrosine-Phosphatases; Phosphoprotein Phosphatases; Cell Division; Cell Differentiation

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APA (6^th Edition):

Pan, M. (1993). Protein-tyrosine phosphatases : regulation of cell growth and differentiation. (Doctoral Dissertation). Oregon Health Sciences University. Retrieved from doi:10.6083/M4P55KQ3 ; http://digitalcommons.ohsu.edu/etd/2843

Chicago Manual of Style (16^th Edition):

Pan, Ming-gui. “Protein-tyrosine phosphatases : regulation of cell growth and differentiation.” 1993. Doctoral Dissertation, Oregon Health Sciences University. Accessed April 15, 2021. doi:10.6083/M4P55KQ3 ; http://digitalcommons.ohsu.edu/etd/2843.

MLA Handbook (7^th Edition):

Pan, Ming-gui. “Protein-tyrosine phosphatases : regulation of cell growth and differentiation.” 1993. Web. 15 Apr 2021.

Vancouver:

Pan M. Protein-tyrosine phosphatases : regulation of cell growth and differentiation. [Internet] [Doctoral dissertation]. Oregon Health Sciences University; 1993. [cited 2021 Apr 15]. Available from: doi:10.6083/M4P55KQ3 ; http://digitalcommons.ohsu.edu/etd/2843.

Council of Science Editors:

Pan M. Protein-tyrosine phosphatases : regulation of cell growth and differentiation. [Doctoral Dissertation]. Oregon Health Sciences University; 1993. Available from: doi:10.6083/M4P55KQ3 ; http://digitalcommons.ohsu.edu/etd/2843

Hong Kong University of Science and Technology

6. Shu, Yiwei. Phosphorylated ERF110 regulates arabidopsis inflorescence number and etiolated hypocotyl length.

Degree: 2010, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-8056 ; https://doi.org/10.14711/thesis-b1115579 ; http://repository.ust.hk/ir/bitstream/1783.1-8056/1/th_redirect.html

► Protein phosphorylation plays an essential role in nearly all aspects of life cycle. Ethylene linear signal pathway has been established through molecular genetic studies on… (more)

Subjects/Keywords: Phosphoprotein phosphatases ; Ethylene ; Synthesis ; Peptides ; Analysis

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APA (6^th Edition):

Shu, Y. (2010). Phosphorylated ERF110 regulates arabidopsis inflorescence number and etiolated hypocotyl length. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-8056 ; https://doi.org/10.14711/thesis-b1115579 ; http://repository.ust.hk/ir/bitstream/1783.1-8056/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shu, Yiwei. “Phosphorylated ERF110 regulates arabidopsis inflorescence number and etiolated hypocotyl length.” 2010. Thesis, Hong Kong University of Science and Technology. Accessed April 15, 2021. http://repository.ust.hk/ir/Record/1783.1-8056 ; https://doi.org/10.14711/thesis-b1115579 ; http://repository.ust.hk/ir/bitstream/1783.1-8056/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shu, Yiwei. “Phosphorylated ERF110 regulates arabidopsis inflorescence number and etiolated hypocotyl length.” 2010. Web. 15 Apr 2021.

Vancouver:

Shu Y. Phosphorylated ERF110 regulates arabidopsis inflorescence number and etiolated hypocotyl length. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2010. [cited 2021 Apr 15]. Available from: http://repository.ust.hk/ir/Record/1783.1-8056 ; https://doi.org/10.14711/thesis-b1115579 ; http://repository.ust.hk/ir/bitstream/1783.1-8056/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shu Y. Phosphorylated ERF110 regulates arabidopsis inflorescence number and etiolated hypocotyl length. [Thesis]. Hong Kong University of Science and Technology; 2010. Available from: http://repository.ust.hk/ir/Record/1783.1-8056 ; https://doi.org/10.14711/thesis-b1115579 ; http://repository.ust.hk/ir/bitstream/1783.1-8056/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Hong Kong University of Science and Technology

7. Zhao, Xiaotao. The role of protein phosphatase signaling in the formation of the neuromuscular junction.

Degree: 2004, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-2221 ; https://doi.org/10.14711/thesis-b843346 ; http://repository.ust.hk/ir/bitstream/1783.1-2221/1/th_redirect.html

► The neuromuscular junction (NMJ) is the synapse formed between a motor nerve and a muscle cell. A hallmark step in NMJ development is the postsynaptic… (more)

▼ The neuromuscular junction (NMJ) is the synapse formed between a motor nerve and a muscle cell. A hallmark step in NMJ development is the postsynaptic clustering of muscle acetylcholine receptors (AChRs) that is orchestrated by nerve-secreted agrin and its receptor, muscle-specific kinase (MuSK). In the downstream signaling cascade initiated by MuSK, protein kinases feature prominently and bring about the phosphorylation, clustering and cytoskeletal anchoring of AChRs and associated proteins. In contrast, little is known about how protein phosphatases counter-balance the actions of MuSK and other protein kinases during NMJ development. For my thesis research I investigated the involvement of protein tyrosine and ser/thr phosphatases in regulating postsynaptic signaling at the NMJ. Using cultured C2 mouse myotubes I first showed that the general tyrosine phosphatase inhibitor Na-pervanadate functionally activated MuSK and enhanced both agrin-independent and agrin-dependent AChR clustering in muscle cells. Next, by immuno-screening I identified the SH2 domain-containing phosphatase Shp2 as a major tyrosine phosphatase in C2 myotubes and demonstrated that its selective down-regulation by RNA interference increased MuSK activation and AChR clustering. Additionally, I found that agrin-treatment of C2 myotubes increased the tyrosine phosphorylation and Shp2-interaction of the Shp2-activating protein SIRPα1, suggesting that Shp2 functions in a feedback loop to regulate agrin/MuSK signaling. Interestingly, depletion of Shp2 raised the basal tyrosine phosphorylation of SIRPα1 to levels normally obtained with agrin, indicating that SIRPα1 is also a substrate of Shp2 in muscle cells. Lastly, using pharmacological and molecular approaches I showed that the ser/thr phosphatase calcineurin positively regulates MuSK activation and agrin-induced AChR clustering in muscle cells. Taken together, my thesis research findings highlight the importance of protein phosphatases in postsynaptic signaling at the NMJ and provide insights into how balancing actions of protein kinases and phosphatases may determine the formation of synaptic specializations in the developing nervous system.

Subjects/Keywords: Myoneural junction ; Neuromuscular transmission ; Phosphoprotein phosphatases

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APA (6^th Edition):

Zhao, X. (2004). The role of protein phosphatase signaling in the formation of the neuromuscular junction. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-2221 ; https://doi.org/10.14711/thesis-b843346 ; http://repository.ust.hk/ir/bitstream/1783.1-2221/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhao, Xiaotao. “The role of protein phosphatase signaling in the formation of the neuromuscular junction.” 2004. Thesis, Hong Kong University of Science and Technology. Accessed April 15, 2021. http://repository.ust.hk/ir/Record/1783.1-2221 ; https://doi.org/10.14711/thesis-b843346 ; http://repository.ust.hk/ir/bitstream/1783.1-2221/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhao, Xiaotao. “The role of protein phosphatase signaling in the formation of the neuromuscular junction.” 2004. Web. 15 Apr 2021.

Vancouver:

Zhao X. The role of protein phosphatase signaling in the formation of the neuromuscular junction. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2004. [cited 2021 Apr 15]. Available from: http://repository.ust.hk/ir/Record/1783.1-2221 ; https://doi.org/10.14711/thesis-b843346 ; http://repository.ust.hk/ir/bitstream/1783.1-2221/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhao X. The role of protein phosphatase signaling in the formation of the neuromuscular junction. [Thesis]. Hong Kong University of Science and Technology; 2004. Available from: http://repository.ust.hk/ir/Record/1783.1-2221 ; https://doi.org/10.14711/thesis-b843346 ; http://repository.ust.hk/ir/bitstream/1783.1-2221/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

8. Lindesmith, Lisa Chon. YopH is degraded into fragments that retain protein tyrosine phosphatase activity in Yersinia pestis.

Degree: MS, Department of Microbiology, 1993, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:23272

Subjects/Keywords: Yersinia pestis; Bacterial proteins; Phosphoprotein phosphatases

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APA (6^th Edition):

Lindesmith, L. C. (1993). YopH is degraded into fragments that retain protein tyrosine phosphatase activity in Yersinia pestis. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:23272

Chicago Manual of Style (16^th Edition):

Lindesmith, Lisa Chon. “YopH is degraded into fragments that retain protein tyrosine phosphatase activity in Yersinia pestis.” 1993. Masters Thesis, Michigan State University. Accessed April 15, 2021. http://etd.lib.msu.edu/islandora/object/etd:23272.

MLA Handbook (7^th Edition):

Lindesmith, Lisa Chon. “YopH is degraded into fragments that retain protein tyrosine phosphatase activity in Yersinia pestis.” 1993. Web. 15 Apr 2021.

Vancouver:

Lindesmith LC. YopH is degraded into fragments that retain protein tyrosine phosphatase activity in Yersinia pestis. [Internet] [Masters thesis]. Michigan State University; 1993. [cited 2021 Apr 15]. Available from: http://etd.lib.msu.edu/islandora/object/etd:23272.

Council of Science Editors:

Lindesmith LC. YopH is degraded into fragments that retain protein tyrosine phosphatase activity in Yersinia pestis. [Masters Thesis]. Michigan State University; 1993. Available from: http://etd.lib.msu.edu/islandora/object/etd:23272

University of Texas Southwestern Medical Center

9. Esplin, Edward D. Characterization of the Role of the PP2A-AB Gene, a Putative Tumor Suppressor, in Cell Growth and Tumorigenesis.

Degree: 2005, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/418

► The PP2A-Aβ gene (PPP2R1B) encodes the β isoform of the A subunit of serine/threonine protein phosphatase 2A. Mutations in PP2A-Aβ have been identified in a… (more)

▼ The PP2A-Aβ gene (PPP2R1B) encodes the β isoform of the A subunit of serine/threonine protein phosphatase 2A. Mutations in PP2A-Aβ have been identified in a wide variety of human cancers. The important role of protein phosphatase 2A in down regulating cell growth suggests these mutations may contribute to cancer susceptibility and tumorigenesis by compromising the function of PP2A-Aβ and that PP2A-Aβ may act as a tumor suppressor. Screening of cancer patient DNAs revealed an association between a germline alteration of the PP2A-Aβ and breast carcinoma and identified alterations of PP2A-Aβ in lung carcinoma and ALL patient genomic DNAs. The biochemical consequences of these PP2A-Aβ mutations on PP2A function were investigated by in vitro and in vivo coimmunoprecipitations between the PP2A-Aβ subunit and the B and C subunits of PP2A. These studies showed mutations in PP2A-Aβ confer a loss of function by reducing its ability to bind the B and C subunits, destabilizing the PP2A-Aβ containing PP2A complex. The affect of the PP2A-Aβ gene on cell growth was analyzed by transfecting the PP2A-Aβ gene into cancer cell line deficient for wild type PP2A-Aβ and deriving stable cell lines. The PP2A-Aβ gene appeared to confer a relative disadvantage to transfected cells, resulting in a lower fraction of derived stable lines compared to controls. These cell lines were tested for proliferation and colony formation in soft agar. No significant difference was observed in the growth rate of PP2A-Aβ cell lines compared to controls. One of the PP2A-Aβ stable cell lines demonstrated dramatic suppression of colony formation in soft agar, but this was not confirmed in any additional PP2A-Aβ stable cell lines, leaving this finding inconclusive. The stable cell lines were also analyzed by Western blotting for changes in the Wnt signaling cascade. Cell lines expressing exogenous PP2A-Aβ are found to have lower levels of β-catenin compared to control cell lines. This suggests that the PP2A-Aβ gene is involved in regulating the Wnt signaling pathway, which is shown to be involved in cell growth control and is similarly affected by known tumor suppressor genes. Advisors/Committee Members: Mumby, Marc C..

Subjects/Keywords: Tumorigenesis; Cell Transformation, Neoplastic; Phosphoprotein Phosphatases; Breast Neoplasms

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APA (6^th Edition):

Esplin, E. D. (2005). Characterization of the Role of the PP2A-AB Gene, a Putative Tumor Suppressor, in Cell Growth and Tumorigenesis. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/418

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Esplin, Edward D. “Characterization of the Role of the PP2A-AB Gene, a Putative Tumor Suppressor, in Cell Growth and Tumorigenesis.” 2005. Thesis, University of Texas Southwestern Medical Center. Accessed April 15, 2021. http://hdl.handle.net/2152.5/418.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Esplin, Edward D. “Characterization of the Role of the PP2A-AB Gene, a Putative Tumor Suppressor, in Cell Growth and Tumorigenesis.” 2005. Web. 15 Apr 2021.

Vancouver:

Esplin ED. Characterization of the Role of the PP2A-AB Gene, a Putative Tumor Suppressor, in Cell Growth and Tumorigenesis. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2005. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/2152.5/418.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Esplin ED. Characterization of the Role of the PP2A-AB Gene, a Putative Tumor Suppressor, in Cell Growth and Tumorigenesis. [Thesis]. University of Texas Southwestern Medical Center; 2005. Available from: http://hdl.handle.net/2152.5/418

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

10. McNamara, Ryan Philip. Enzymatic Disassembly of Promoter Bound 7SK snRNP Drives Transcription Elongation of HIV and Cellular Genes.

Degree: 2015, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/2724

► Gene expression of the human immunodeficiency virus (HIV) and cellular primary responsive genes (PRG’s) is regulated at the step of transcription elongation. Shortly after transcription… (more)

▼ Gene expression of the human immunodeficiency virus (HIV) and cellular primary responsive genes (PRG’s) is regulated at the step of transcription elongation. Shortly after transcription initiation, RNA Polymerase II (Pol II) pauses and it only enters into productive elongation after inducible transcription factors (TF’s) recruit the P-TEFb kinase to phosphorylate Pol II in response to stimuli. To ensure tight regulation of this process, the majority of P-TEFb is held in a catalytically inactive form, reversibly bound to the 7SK small nuclear ribonucleoprotein (snRNP). In the absence of stimuli, the 7SK snRNP resides in both the nucleoplasm and promoter regions. However, an understanding of how TF’s capture P-TEFb from the 7SK snRNP at the promoter and the mechanism and purpose of localizing the 7SK snRNP to promoters has been largely unexplored. It was therefore my goal to biochemically and functionally characterize this pathway through the use of both the HIV encoded TF Tat and cellular TF’s such as nuclear factor kappa b (NF-κB). Detailed throughout this dissertation, I present the novel findings that HIV Tat and NF-κB function to recruit the PPM1G phosphatase to their targeted promoters, which dephosphorylates P-TEFb and triggers its release from the 7SK snRNP. Additionally, this extraction of P-TEFb from the 7SK snRNP occurs at promoters through the transcriptional regulator KAP1, which physically tethers the snRNP to promoters genome wide. Recruitment of the 7SK snRNP complex occurs after transcription initiation, allowing P-TEFb to be directly positioned for rapid extraction by TF’s upon stimuli and transferred onto the paused Pol II. The enzymatic uncoupling of P-TEFb from the promoter bound 7SK snRNP enables rapid Pol II elongation and gene expression in response to stimuli (for PRG’s) or in the presence of Tat (for HIV). Ultimately, these findings indicate that inducible transcription programs can rapidly respond to environmental cues through the localized positioning of elongation factors at promoters. Moreover, these findings illustrate that HIV has evolved to hijack a cellular gene expression program, thus leading to viral takeover of the host and progression of AIDS. Advisors/Committee Members: Cobb, Melanie H., D'Orso, Iván, Conrad, Nicholas, Kahn, Jeffrey.

Subjects/Keywords: Phosphoprotein Phosphatases; Positive Transcriptional Elongation Factor B; Promoter Regions, Genetic; Ribonucleoproteins, Small Nuclear; Transcription Elongation, Genetic

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APA (6^th Edition):

McNamara, R. P. (2015). Enzymatic Disassembly of Promoter Bound 7SK snRNP Drives Transcription Elongation of HIV and Cellular Genes. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/2724

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McNamara, Ryan Philip. “Enzymatic Disassembly of Promoter Bound 7SK snRNP Drives Transcription Elongation of HIV and Cellular Genes.” 2015. Thesis, University of Texas Southwestern Medical Center. Accessed April 15, 2021. http://hdl.handle.net/2152.5/2724.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McNamara, Ryan Philip. “Enzymatic Disassembly of Promoter Bound 7SK snRNP Drives Transcription Elongation of HIV and Cellular Genes.” 2015. Web. 15 Apr 2021.

Vancouver:

McNamara RP. Enzymatic Disassembly of Promoter Bound 7SK snRNP Drives Transcription Elongation of HIV and Cellular Genes. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2015. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/2152.5/2724.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McNamara RP. Enzymatic Disassembly of Promoter Bound 7SK snRNP Drives Transcription Elongation of HIV and Cellular Genes. [Thesis]. University of Texas Southwestern Medical Center; 2015. Available from: http://hdl.handle.net/2152.5/2724

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Hong Kong University of Science and Technology

11. Zhou, Jie. Functions of tyrosine kinases and phosphatases in presynaptic development during neuromuscular junction formation.

Degree: 2007, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-2874 ; https://doi.org/10.14711/thesis-b943606 ; http://repository.ust.hk/ir/bitstream/1783.1-2874/1/th_redirect.html

► The neuromuscular junction (NMJ), a chemical synapse formed between a motoneuron and a muscle fiber, has been widely and successfully utilized in studying chemical synapses.… (more)

Subjects/Keywords: Myoneural junction ; Protein-tyrosine kinase ; Phosphoprotein phosphatases ; Presynaptic receptors

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APA (6^th Edition):

Zhou, J. (2007). Functions of tyrosine kinases and phosphatases in presynaptic development during neuromuscular junction formation. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-2874 ; https://doi.org/10.14711/thesis-b943606 ; http://repository.ust.hk/ir/bitstream/1783.1-2874/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhou, Jie. “Functions of tyrosine kinases and phosphatases in presynaptic development during neuromuscular junction formation.” 2007. Thesis, Hong Kong University of Science and Technology. Accessed April 15, 2021. http://repository.ust.hk/ir/Record/1783.1-2874 ; https://doi.org/10.14711/thesis-b943606 ; http://repository.ust.hk/ir/bitstream/1783.1-2874/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhou, Jie. “Functions of tyrosine kinases and phosphatases in presynaptic development during neuromuscular junction formation.” 2007. Web. 15 Apr 2021.

Vancouver:

Zhou J. Functions of tyrosine kinases and phosphatases in presynaptic development during neuromuscular junction formation. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2007. [cited 2021 Apr 15]. Available from: http://repository.ust.hk/ir/Record/1783.1-2874 ; https://doi.org/10.14711/thesis-b943606 ; http://repository.ust.hk/ir/bitstream/1783.1-2874/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhou J. Functions of tyrosine kinases and phosphatases in presynaptic development during neuromuscular junction formation. [Thesis]. Hong Kong University of Science and Technology; 2007. Available from: http://repository.ust.hk/ir/Record/1783.1-2874 ; https://doi.org/10.14711/thesis-b943606 ; http://repository.ust.hk/ir/bitstream/1783.1-2874/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Hong Kong University of Science and Technology

12. Ng, Wai Sun. Multi-functions of the PP2A domain of axin.

Degree: 2004, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-3764 ; https://doi.org/10.14711/thesis-b839570 ; http://repository.ust.hk/ir/bitstream/1783.1-3764/1/th_redirect.html

► Axin serves as a scaffold protein in Wnt signaling pathway to negatively regulate the stability of β-catenin, and it also facilitates the c-Jun N-terminal/stress-activated protein… (more)

Subjects/Keywords: Protein-protein interactions ; Protein binding ; Phosphoprotein phosphatases

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APA (6^th Edition):

Ng, W. S. (2004). Multi-functions of the PP2A domain of axin. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-3764 ; https://doi.org/10.14711/thesis-b839570 ; http://repository.ust.hk/ir/bitstream/1783.1-3764/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ng, Wai Sun. “Multi-functions of the PP2A domain of axin.” 2004. Thesis, Hong Kong University of Science and Technology. Accessed April 15, 2021. http://repository.ust.hk/ir/Record/1783.1-3764 ; https://doi.org/10.14711/thesis-b839570 ; http://repository.ust.hk/ir/bitstream/1783.1-3764/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ng, Wai Sun. “Multi-functions of the PP2A domain of axin.” 2004. Web. 15 Apr 2021.

Vancouver:

Ng WS. Multi-functions of the PP2A domain of axin. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2004. [cited 2021 Apr 15]. Available from: http://repository.ust.hk/ir/Record/1783.1-3764 ; https://doi.org/10.14711/thesis-b839570 ; http://repository.ust.hk/ir/bitstream/1783.1-3764/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ng WS. Multi-functions of the PP2A domain of axin. [Thesis]. Hong Kong University of Science and Technology; 2004. Available from: http://repository.ust.hk/ir/Record/1783.1-3764 ; https://doi.org/10.14711/thesis-b839570 ; http://repository.ust.hk/ir/bitstream/1783.1-3764/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Florida Atlantic University

13. Lee, LaTasha Hoskins. Characterization of receptor protein tyrosine phosphatase PTP69D in the giant fiber circuit.

Degree: 2014, Florida Atlantic University

URL: http://purl.flvc.org/fau/fd/FA00004301 ; (URL) http://purl.flvc.org/fau/fd/FA00004301

►

Summary: PTP69D is a receptor protein tyrosine phosphatase (RPTP) with two intracellular catalytic domains (Cat1 and Cat2), which has been shown to play a role… (more)

Subjects/Keywords: Drosophila melanogaster.; Protein-tyrosine phosphatase – Metabolism.; Protein-tyrosine kinase.; Protein kinases – Inhibitors.; Phosphoprotein phosphatases.; Transcription factors.; Cell receptors.; Cellular signal transduction.

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APA (6^th Edition):

Lee, L. H. (2014). Characterization of receptor protein tyrosine phosphatase PTP69D in the giant fiber circuit. (Thesis). Florida Atlantic University. Retrieved from http://purl.flvc.org/fau/fd/FA00004301 ; (URL) http://purl.flvc.org/fau/fd/FA00004301

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lee, LaTasha Hoskins. “Characterization of receptor protein tyrosine phosphatase PTP69D in the giant fiber circuit.” 2014. Thesis, Florida Atlantic University. Accessed April 15, 2021. http://purl.flvc.org/fau/fd/FA00004301 ; (URL) http://purl.flvc.org/fau/fd/FA00004301.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lee, LaTasha Hoskins. “Characterization of receptor protein tyrosine phosphatase PTP69D in the giant fiber circuit.” 2014. Web. 15 Apr 2021.

Vancouver:

Lee LH. Characterization of receptor protein tyrosine phosphatase PTP69D in the giant fiber circuit. [Internet] [Thesis]. Florida Atlantic University; 2014. [cited 2021 Apr 15]. Available from: http://purl.flvc.org/fau/fd/FA00004301 ; (URL) http://purl.flvc.org/fau/fd/FA00004301.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lee LH. Characterization of receptor protein tyrosine phosphatase PTP69D in the giant fiber circuit. [Thesis]. Florida Atlantic University; 2014. Available from: http://purl.flvc.org/fau/fd/FA00004301 ; (URL) http://purl.flvc.org/fau/fd/FA00004301

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

14. Zhai, Yifan. Characterization of protein tyrosine phosphatases in human breast epithelial cells neoplastically transformed by the NEU oncogene : the potential role as a tumor suppressor.

Degree: PhD, Department of Pharmacology and Toxicology, 1993, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:22489

Subjects/Keywords: Phosphoprotein phosphatases; Oncogenes; Breast – Cancer; Tyrosine – Physiological effect

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APA (6^th Edition):

Zhai, Y. (1993). Characterization of protein tyrosine phosphatases in human breast epithelial cells neoplastically transformed by the NEU oncogene : the potential role as a tumor suppressor. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:22489

Chicago Manual of Style (16^th Edition):

Zhai, Yifan. “Characterization of protein tyrosine phosphatases in human breast epithelial cells neoplastically transformed by the NEU oncogene : the potential role as a tumor suppressor.” 1993. Doctoral Dissertation, Michigan State University. Accessed April 15, 2021. http://etd.lib.msu.edu/islandora/object/etd:22489.

MLA Handbook (7^th Edition):

Zhai, Yifan. “Characterization of protein tyrosine phosphatases in human breast epithelial cells neoplastically transformed by the NEU oncogene : the potential role as a tumor suppressor.” 1993. Web. 15 Apr 2021.

Vancouver:

Zhai Y. Characterization of protein tyrosine phosphatases in human breast epithelial cells neoplastically transformed by the NEU oncogene : the potential role as a tumor suppressor. [Internet] [Doctoral dissertation]. Michigan State University; 1993. [cited 2021 Apr 15]. Available from: http://etd.lib.msu.edu/islandora/object/etd:22489.

Council of Science Editors:

Zhai Y. Characterization of protein tyrosine phosphatases in human breast epithelial cells neoplastically transformed by the NEU oncogene : the potential role as a tumor suppressor. [Doctoral Dissertation]. Michigan State University; 1993. Available from: http://etd.lib.msu.edu/islandora/object/etd:22489

University of Lethbridge

15. Lanser, Brittany. Characterization of checkpoint adaptation in human fibroblastic glioma cells and an analysis of protein phosphatase inhibitors .

Degree: 2012, University of Lethbridge

URL: http://hdl.handle.net/10133/3390

► This thesis reports that checkpoint adaptation occurs in human brain cancer cells. M059K cells, after treatment with camptothecin (CPT), recruited γ-histone H2AX, phosphorylated Chk1 and… (more)

Subjects/Keywords: Gliomas; Cancer cells – Adaptation; Brain – Tumors; Cellular control mechanisms; Cell cycle – Regulation; Phosphoprotein phosphatases; Dissertations, Academic

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APA (6^th Edition):

Lanser, B. (2012). Characterization of checkpoint adaptation in human fibroblastic glioma cells and an analysis of protein phosphatase inhibitors . (Thesis). University of Lethbridge. Retrieved from http://hdl.handle.net/10133/3390

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lanser, Brittany. “Characterization of checkpoint adaptation in human fibroblastic glioma cells and an analysis of protein phosphatase inhibitors .” 2012. Thesis, University of Lethbridge. Accessed April 15, 2021. http://hdl.handle.net/10133/3390.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lanser, Brittany. “Characterization of checkpoint adaptation in human fibroblastic glioma cells and an analysis of protein phosphatase inhibitors .” 2012. Web. 15 Apr 2021.

Vancouver:

Lanser B. Characterization of checkpoint adaptation in human fibroblastic glioma cells and an analysis of protein phosphatase inhibitors . [Internet] [Thesis]. University of Lethbridge; 2012. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/10133/3390.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lanser B. Characterization of checkpoint adaptation in human fibroblastic glioma cells and an analysis of protein phosphatase inhibitors . [Thesis]. University of Lethbridge; 2012. Available from: http://hdl.handle.net/10133/3390

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New South Wales

16. Holst, Jeffrey Alexander. Regulation of mast cell secretion by protein phosphatase 1 and 2A.

Degree: Medicine. Clinical School - St Vincent's Hospital, 2003, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/69362 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:70741/SOURCE01?view=true

Subjects/Keywords: Phosphoprotein phosphatases; Mast cells; Thesis Digitisation Program

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APA (6^th Edition):

Holst, J. A. (2003). Regulation of mast cell secretion by protein phosphatase 1 and 2A. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/69362 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:70741/SOURCE01?view=true

Chicago Manual of Style (16^th Edition):

Holst, Jeffrey Alexander. “Regulation of mast cell secretion by protein phosphatase 1 and 2A.” 2003. Doctoral Dissertation, University of New South Wales. Accessed April 15, 2021. http://handle.unsw.edu.au/1959.4/69362 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:70741/SOURCE01?view=true.

MLA Handbook (7^th Edition):

Holst, Jeffrey Alexander. “Regulation of mast cell secretion by protein phosphatase 1 and 2A.” 2003. Web. 15 Apr 2021.

Vancouver:

Holst JA. Regulation of mast cell secretion by protein phosphatase 1 and 2A. [Internet] [Doctoral dissertation]. University of New South Wales; 2003. [cited 2021 Apr 15]. Available from: http://handle.unsw.edu.au/1959.4/69362 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:70741/SOURCE01?view=true.

Council of Science Editors:

Holst JA. Regulation of mast cell secretion by protein phosphatase 1 and 2A. [Doctoral Dissertation]. University of New South Wales; 2003. Available from: http://handle.unsw.edu.au/1959.4/69362 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:70741/SOURCE01?view=true

East Carolina University

17. DeVaul, Nicole. PPP1R42 is a positive regulator of PP1 in centrosome duplication and separation and cilia dynamics.

Degree: PhD, Anatomy and Cell Biology, 2014, East Carolina University

URL: http://hdl.handle.net/10342/4670

► The centrosome is a dynamic structure that undergoes structural and functional transitions, which are coordinated with the cell cycle. It functions as the microtubule organizing… (more)

▼ The centrosome is a dynamic structure that undergoes structural and functional transitions, which are coordinated with the cell cycle. It functions as the microtubule organizing center (MTOC) in interphase, duplicates and separates in S-G â‚‚ forms the bipolar spindle poles in mitosis, and forms the basal body that assembles and sustains the primary cilium in Gâ‚€. Transitions of the functional state of the centrosome, here termed centrosome dynamics, must be carefully regulated. Errors in centrosome function result in mitotic defects promoting cancer as well as a class of disorders termed ciliopathies. Coordinated activity of phosphatases and kinases is required for proper control of centrosome function during the cell cycle. This study investigates a regulatory subunit of protein phosphatase 1 (PP1), phosphoprotein phosphatase regulatory subunit 42 (PPP1R42), and its role in control of centrosome dynamics by analyzing its regulatory effects on centrosome function and downstream targets of PP1, the centrosomal kinases never in mitosis gene-A related kinase 2 (Nek2) and Aurora A. In addition, this work investigates how these two kinases interact to control cilia assembly and disassembly. PPP1R42 is localized to the centrosome in human retinal pigmented epithelial (ARPE-19) cells and positively regulates PP1. Manipulation of cellular PPP1R42 protein levels causes changes in centrosome number, number of ciliated cells, cilia structure, and Nek2 kinase activity. Overexpression of Nek2 and Aurora A causes a decrease in cilia number. However, by using kinase dead versions of these kinases, we were able to determine that the effect of each individual kinase on cilia growth is dependent on whether cilia are assembling or disassembling. Nek2 and Aurora A negatively regulate one another during cilia assembly; however, both Nek2 and Aurora A are jointly required for cilia disassembly. Together, these data have uncovered a novel role for a positive PP1 regulator and provided evidence that PP1 negatively regulates Nek2 and Aurora A to inhibit centrosome duplication/separation and promote cilia assembly. Centrosomes are necessary for cell proliferation and function and undergo transitions linked with the cell cycle. The centrosome transitions from the MTOC to the basal body or mitotic spindle poles and must duplicate once per cell cycle. Misregulation of these events leads to cancers or ciliopathies. Centrosome amplification is a hallmark of many cancers and results in chromosome segregation errors and genomic instability. Defects in the structure and function of primary cilia are the root cause of a class of inherited disorders classified as ciliopathies. These diseases manifest in a variety of symptoms throughout the body, which reflects the ubiquitous presence of primary cilia and their crucial role in cell function and development. This work provides new information that will support improvements in the diagnosis and treatments of both cancers and ciliopathies. Advisors/Committee Members: Sperry, Ann O. (advisor).

Subjects/Keywords: Cellular biology; Aurora A; Centrosome; Cilia; Nek2; PP1; PPP1R42; Neoplasms; Phosphoprotein Phosphatases – physiology; Protein-Serine-Threonine Kinases – physiology; Centrosome – physiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

DeVaul, N. (2014). PPP1R42 is a positive regulator of PP1 in centrosome duplication and separation and cilia dynamics. (Doctoral Dissertation). East Carolina University. Retrieved from http://hdl.handle.net/10342/4670

Chicago Manual of Style (16^th Edition):

DeVaul, Nicole. “PPP1R42 is a positive regulator of PP1 in centrosome duplication and separation and cilia dynamics.” 2014. Doctoral Dissertation, East Carolina University. Accessed April 15, 2021. http://hdl.handle.net/10342/4670.

MLA Handbook (7^th Edition):

DeVaul, Nicole. “PPP1R42 is a positive regulator of PP1 in centrosome duplication and separation and cilia dynamics.” 2014. Web. 15 Apr 2021.

Vancouver:

DeVaul N. PPP1R42 is a positive regulator of PP1 in centrosome duplication and separation and cilia dynamics. [Internet] [Doctoral dissertation]. East Carolina University; 2014. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/10342/4670.

Council of Science Editors:

DeVaul N. PPP1R42 is a positive regulator of PP1 in centrosome duplication and separation and cilia dynamics. [Doctoral Dissertation]. East Carolina University; 2014. Available from: http://hdl.handle.net/10342/4670

18. Fjeld, Clark Charles. The catalytic mechanism of human serine.

Degree: MS, 1999, Oregon Health Sciences University

URL: doi:10.6083/M42N50KH ; http://digitalcommons.ohsu.edu/etd/3375

Subjects/Keywords: Phosphoprotein Phosphatases; Phosphorylation; Catalysis; Serine – chemistry; Threonine – chemistry; Metalloproteins – chemistry

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APA (6^th Edition):

Fjeld, C. C. (1999). The catalytic mechanism of human serine. (Thesis). Oregon Health Sciences University. Retrieved from doi:10.6083/M42N50KH ; http://digitalcommons.ohsu.edu/etd/3375

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fjeld, Clark Charles. “The catalytic mechanism of human serine.” 1999. Thesis, Oregon Health Sciences University. Accessed April 15, 2021. doi:10.6083/M42N50KH ; http://digitalcommons.ohsu.edu/etd/3375.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fjeld, Clark Charles. “The catalytic mechanism of human serine.” 1999. Web. 15 Apr 2021.

Vancouver:

Fjeld CC. The catalytic mechanism of human serine. [Internet] [Thesis]. Oregon Health Sciences University; 1999. [cited 2021 Apr 15]. Available from: doi:10.6083/M42N50KH ; http://digitalcommons.ohsu.edu/etd/3375.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fjeld CC. The catalytic mechanism of human serine. [Thesis]. Oregon Health Sciences University; 1999. Available from: doi:10.6083/M42N50KH ; http://digitalcommons.ohsu.edu/etd/3375

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Chen, Mei-Shya. The role of phosphoprotein phosphatase 5 in glucocorticoid signaling.

Degree: PhD, 1998, Oregon Health Sciences University

URL: doi:10.6083/M4C53J2M ; http://digitalcommons.ohsu.edu/etd/2590

Subjects/Keywords: Phosphoprotein Phosphatases – physiology; Glucocorticoids – physiology; Signal Transduction; Receptors, Steroid – physiology

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APA (6^th Edition):

Chen, M. (1998). The role of phosphoprotein phosphatase 5 in glucocorticoid signaling. (Doctoral Dissertation). Oregon Health Sciences University. Retrieved from doi:10.6083/M4C53J2M ; http://digitalcommons.ohsu.edu/etd/2590

Chicago Manual of Style (16^th Edition):

Chen, Mei-Shya. “The role of phosphoprotein phosphatase 5 in glucocorticoid signaling.” 1998. Doctoral Dissertation, Oregon Health Sciences University. Accessed April 15, 2021. doi:10.6083/M4C53J2M ; http://digitalcommons.ohsu.edu/etd/2590.

MLA Handbook (7^th Edition):

Chen, Mei-Shya. “The role of phosphoprotein phosphatase 5 in glucocorticoid signaling.” 1998. Web. 15 Apr 2021.

Vancouver:

Chen M. The role of phosphoprotein phosphatase 5 in glucocorticoid signaling. [Internet] [Doctoral dissertation]. Oregon Health Sciences University; 1998. [cited 2021 Apr 15]. Available from: doi:10.6083/M4C53J2M ; http://digitalcommons.ohsu.edu/etd/2590.

Council of Science Editors:

Chen M. The role of phosphoprotein phosphatase 5 in glucocorticoid signaling. [Doctoral Dissertation]. Oregon Health Sciences University; 1998. Available from: doi:10.6083/M4C53J2M ; http://digitalcommons.ohsu.edu/etd/2590

20. Satish Kumar. Transcriptional regulation in Drosophila by intracellular calcium;.

Degree: 2013, University of Mysore

URL: http://shodhganga.inflibnet.ac.in/handle/10603/37080

newline

Advisors/Committee Members: Gaiti Hasan.

Subjects/Keywords: Biochemistry; Brain – Growth; Drosophila melanogaster – Development; Phosphoprotein phosphatases; Phosphorylation; RNA; RNA – Analysis

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APA (6^th Edition):

Kumar, S. (2013). Transcriptional regulation in Drosophila by intracellular calcium;. (Thesis). University of Mysore. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/37080

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kumar, Satish. “Transcriptional regulation in Drosophila by intracellular calcium;.” 2013. Thesis, University of Mysore. Accessed April 15, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/37080.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kumar, Satish. “Transcriptional regulation in Drosophila by intracellular calcium;.” 2013. Web. 15 Apr 2021.

Vancouver:

Kumar S. Transcriptional regulation in Drosophila by intracellular calcium;. [Internet] [Thesis]. University of Mysore; 2013. [cited 2021 Apr 15]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/37080.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kumar S. Transcriptional regulation in Drosophila by intracellular calcium;. [Thesis]. University of Mysore; 2013. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/37080

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Hong Kong University of Science and Technology

21. Ma, On Ki. Association of the N-methyl-D-aspartate receptor subunit NR3A with protein phosphatase 2A : structural analysis by site-directed mutagenesis.

Degree: 2003, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-3900 ; https://doi.org/10.14711/thesis-b802030 ; http://repository.ust.hk/ir/bitstream/1783.1-3900/1/th_redirect.html

► N-methyl-D-aspartate receptors (NMDARs) belong to a subclass of excitatory ionotropic glutamate receptors that play important roles in neuronal differentiation, synaptic transmission, synaptic integration and plasticity.… (more)

▼ N-methyl-D-aspartate receptors (NMDARs) belong to a subclass of excitatory ionotropic glutamate receptors that play important roles in neuronal differentiation, synaptic transmission, synaptic integration and plasticity. NMDARs are widely distributed in the mammalian central nervous system (CNS). Their heteromultimeric structures are composed of at least two essential NR1 subunits, one or more regulatory NR2A-D subunits and/or the additional NR3A-B subunits. Overstimulation of NMDARs contributes to the neurodegeneration observed in acute and progressive degenerative neurological disorders. It was reported previously that the association of the serine/threonine protein phosphatase 2A (PP2A) with the NR3A subunit is involved in the regulation of NMDAR function through modulation of the phosphorylation state of NR1. Therefore it is important to gain insight into the interaction between the NR3A subunit and PP2A. In this study, data from co-immunoprecipitation experiments using rat brain synaptic plasma membranes (SPM) revealed that NR3A was associated with the PP2A holoenzyme but not the core enzyme. In addition, the molecular determinants required for the formation of the NR3A-PP2A complex were characterized by site-directed mutagenesis. In particular, alanine-scanning mutagenesis was performed in the previously identified 37-amino acid PP2A-binding domain of the intracellular carboxyl terminal of NR3A subunit (NR3Ac). A yeast two-hybrid system was then used to investigate the effects of the mutations on the interaction of NR3Ac and the catalytic subunit of PP2A (PP2A-C). The data suggest that mutation of either one of three critical amino acids reduced the interaction between the NR3Ac and the PP2A-C by more than 80%. These amino acids are conserved in both human and rat NR3Ac. Co-immunoprecipitation studies indicated that at least one of these critical amino acids is essential for the interaction of NR3A with PP2A in mammalian cells. This project delineates molecular determinants of the association of NR3A with PP2A.

Subjects/Keywords: Neural receptors ; Methyl asparate – Receptors ; Site-specific mutagenesis ; Phosphoprotein phosphatases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ma, O. K. (2003). Association of the N-methyl-D-aspartate receptor subunit NR3A with protein phosphatase 2A : structural analysis by site-directed mutagenesis. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-3900 ; https://doi.org/10.14711/thesis-b802030 ; http://repository.ust.hk/ir/bitstream/1783.1-3900/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ma, On Ki. “Association of the N-methyl-D-aspartate receptor subunit NR3A with protein phosphatase 2A : structural analysis by site-directed mutagenesis.” 2003. Thesis, Hong Kong University of Science and Technology. Accessed April 15, 2021. http://repository.ust.hk/ir/Record/1783.1-3900 ; https://doi.org/10.14711/thesis-b802030 ; http://repository.ust.hk/ir/bitstream/1783.1-3900/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ma, On Ki. “Association of the N-methyl-D-aspartate receptor subunit NR3A with protein phosphatase 2A : structural analysis by site-directed mutagenesis.” 2003. Web. 15 Apr 2021.

Vancouver:

Ma OK. Association of the N-methyl-D-aspartate receptor subunit NR3A with protein phosphatase 2A : structural analysis by site-directed mutagenesis. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2003. [cited 2021 Apr 15]. Available from: http://repository.ust.hk/ir/Record/1783.1-3900 ; https://doi.org/10.14711/thesis-b802030 ; http://repository.ust.hk/ir/bitstream/1783.1-3900/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ma OK. Association of the N-methyl-D-aspartate receptor subunit NR3A with protein phosphatase 2A : structural analysis by site-directed mutagenesis. [Thesis]. Hong Kong University of Science and Technology; 2003. Available from: http://repository.ust.hk/ir/Record/1783.1-3900 ; https://doi.org/10.14711/thesis-b802030 ; http://repository.ust.hk/ir/bitstream/1783.1-3900/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

22. Dunn, Jamie D. Polymer-modified plates for enrichment of phosphopeptides prior to analysis by matrix-assisted laser desorption/ionization mass spectrometry.

Degree: PhD, Department of Chemistry, 2007, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:39070

Subjects/Keywords: Phosphorylation; Phosphoprotein phosphatases; Cellular control mechanisms; Chromatographic analysis; Mass spectrometry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dunn, J. D. (2007). Polymer-modified plates for enrichment of phosphopeptides prior to analysis by matrix-assisted laser desorption/ionization mass spectrometry. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:39070

Chicago Manual of Style (16^th Edition):

Dunn, Jamie D. “Polymer-modified plates for enrichment of phosphopeptides prior to analysis by matrix-assisted laser desorption/ionization mass spectrometry.” 2007. Doctoral Dissertation, Michigan State University. Accessed April 15, 2021. http://etd.lib.msu.edu/islandora/object/etd:39070.

MLA Handbook (7^th Edition):

Dunn, Jamie D. “Polymer-modified plates for enrichment of phosphopeptides prior to analysis by matrix-assisted laser desorption/ionization mass spectrometry.” 2007. Web. 15 Apr 2021.

Vancouver:

Dunn JD. Polymer-modified plates for enrichment of phosphopeptides prior to analysis by matrix-assisted laser desorption/ionization mass spectrometry. [Internet] [Doctoral dissertation]. Michigan State University; 2007. [cited 2021 Apr 15]. Available from: http://etd.lib.msu.edu/islandora/object/etd:39070.

Council of Science Editors:

Dunn JD. Polymer-modified plates for enrichment of phosphopeptides prior to analysis by matrix-assisted laser desorption/ionization mass spectrometry. [Doctoral Dissertation]. Michigan State University; 2007. Available from: http://etd.lib.msu.edu/islandora/object/etd:39070

23. Sheppard, Vonda Chantal. Identification and characterization of diatom kinases catalyzing the phosphorylation of biomineral forming proteins.

Degree: PhD, Chemistry and Biochemistry, 2010, Georgia Tech

URL: http://hdl.handle.net/1853/37227

► Diatoms are unicellular photosynthetic algae that display intricately patterned cell walls made of amorphous silicon dioxide (silica). Long-chain polyamines and highly phosphorylated proteins, silaffins and… (more)

▼ Diatoms are unicellular photosynthetic algae that display intricately patterned cell walls made of amorphous silicon dioxide (silica). Long-chain polyamines and highly phosphorylated proteins, silaffins and silacidins, are believed to play an important role in biosilica formation. The phosphate moieties on silaffins and silacidins play a significant role in biomineral formation, yet no kinase has been identified that phosphorylates these biomineral forming proteins. This dissertation describes the characterization of a novel kinase from the diatom Thalassiosira pseudonana, tpSTK1, which is upregulated during silica formation. A recombinantly expressed histidine-tagged version of tpSTK1 was capable of phosphorylating recombinant silaffins but not recombinant silacidin in vitro. Through establishing methods for subcellular fraction of T. pseudonana membranes in combination with antibody inhibition assay, it was discovered that native tpSTK1 phosphorylates silaffins but not silacidins in vitro (i.e. it exhibits the same substrate specificity as recombinant tpSTK1). As tpSTK1 is an abundant protein in the ER lumen (~ 0.5 % of total ER protein) it seems highly likely to function as a silaffin kinase in vivo. TpSTK1 lacks clear sequence homologs in non-diatom organisms and is the first molecularly characterized kinase that appears to be involved in biomineralization. The predicted kinase domain (KD) of tpSTK2, the only T. pseudonana homolog of tpSTK1, was recombinantly expressed and tested for phosphorylation activity. Recombinant tpSTK2-KD and native tpSTK2 exhibited detectable activity with myelin basic protein, but did not phosphorylate silaffins or silacidins in vitro. Western blot analysis demonstrated that native tpSTK2 was not present in the ER, but associated with the cytosol and Golgi membrane containing subcellular fractions. Advisors/Committee Members: Kroger, Nils (Committee Chair), Hud, Nicholas (Committee Member), Lieberman, Raquel (Committee Member), Milam, Valeria (Committee Member), Payne, Christine (Committee Member).

Subjects/Keywords: Membrane isolation; Protein phosphorylation; Biomineralization; Silica; Phosphoprotein phosphatases; Phosphoproteins

…proteins29. Instead, dentin sialoprotein (DSP) and dentin phosphoprotein (also known… …residues), phosphophoryn (PP) is a highly acidic phosphoprotein with a strong… …phosphoprotein calcification-associated peptide-1 (CAP-1) from the cuticle ( term for… …Kinases and Phosphatases The prevalence of phosphoproteins in biomineralizing organisms from… …protein can be regulated by phosphatases, which are enzymes that remove phosphate groups in a…

10 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sheppard, V. C. (2010). Identification and characterization of diatom kinases catalyzing the phosphorylation of biomineral forming proteins. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/37227

Chicago Manual of Style (16^th Edition):

Sheppard, Vonda Chantal. “Identification and characterization of diatom kinases catalyzing the phosphorylation of biomineral forming proteins.” 2010. Doctoral Dissertation, Georgia Tech. Accessed April 15, 2021. http://hdl.handle.net/1853/37227.

MLA Handbook (7^th Edition):

Sheppard, Vonda Chantal. “Identification and characterization of diatom kinases catalyzing the phosphorylation of biomineral forming proteins.” 2010. Web. 15 Apr 2021.

Vancouver:

Sheppard VC. Identification and characterization of diatom kinases catalyzing the phosphorylation of biomineral forming proteins. [Internet] [Doctoral dissertation]. Georgia Tech; 2010. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/1853/37227.

Council of Science Editors:

Sheppard VC. Identification and characterization of diatom kinases catalyzing the phosphorylation of biomineral forming proteins. [Doctoral Dissertation]. Georgia Tech; 2010. Available from: http://hdl.handle.net/1853/37227

Michigan State University

24. Zhang, Yanfeng. Structural and functional studies of proteins involved in mitochondrial function and structure.

Degree: PhD, Genetics, 2009, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:17199

Subjects/Keywords: Mitochondria; Electron transport; Phosphoprotein phosphatases; Protein kinases; Renin-angiotensin system

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zhang, Y. (2009). Structural and functional studies of proteins involved in mitochondrial function and structure. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:17199

Chicago Manual of Style (16^th Edition):

Zhang, Yanfeng. “Structural and functional studies of proteins involved in mitochondrial function and structure.” 2009. Doctoral Dissertation, Michigan State University. Accessed April 15, 2021. http://etd.lib.msu.edu/islandora/object/etd:17199.

MLA Handbook (7^th Edition):

Zhang, Yanfeng. “Structural and functional studies of proteins involved in mitochondrial function and structure.” 2009. Web. 15 Apr 2021.

Vancouver:

Zhang Y. Structural and functional studies of proteins involved in mitochondrial function and structure. [Internet] [Doctoral dissertation]. Michigan State University; 2009. [cited 2021 Apr 15]. Available from: http://etd.lib.msu.edu/islandora/object/etd:17199.

Council of Science Editors:

Zhang Y. Structural and functional studies of proteins involved in mitochondrial function and structure. [Doctoral Dissertation]. Michigan State University; 2009. Available from: http://etd.lib.msu.edu/islandora/object/etd:17199

Michigan State University

25. Martin, Katie Renee. An integrative approach to understanding PI(3)P signaling and autophagy.

Degree: 2011, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:649

►

Thesis Ph. D. Michigan State University. Cell and Molecular Biology 2011.

To investigate this hypothesis, we performed a cell-based RNA interference screen to identify phosphatases… (more)

▼

Thesis Ph. D. Michigan State University. Cell and Molecular Biology 2011.

To investigate this hypothesis, we performed a cell-based RNA interference screen to identify phosphatases whose loss of function alters cellular PI(3)P . We found that reduced expression of a receptor-like protein tyrosine phosphatase, PTPsigma, increased the abundance of PI(3)P-positive vesicles in cells. Intriguingly, the vesicles in these cells mimicked those observed in autophagic cells. Using a variety of cell biology approaches, we confirmed that PI(3)P signaling and autophagy are elevated in the absence of PTPsigma.As a role for PTPsigma in PI(3)P signaling was unprecedented, much work was required, and still remains, to fully characterize its function in this process. We uncovered that PTPsigma resides on PI(3)P-positive vesicles during both basal and induced autophagy. Further, its internalization from the cell surface and presence on these vesicles is likely controlled through defined proteolytic processing. Finally, loss of PTPsigma in cells appears to promote Vps34 activity as measured in vitro and PTPsigma is capable of interacting with both Vps34 and at least one of its binding partners, Rubicon. We propose a working model where PTPsigma downregulates PI(3)P signaling through control of a phosphotyrosine substrate, yet to be identified, within or closely related to an endocytic Rubicon-containing Vps34 complex. These results are summarized in Chapter 2.Although still elusive, the function of PTPsigma in PI(3)P signaling and autophagy may prove to have important consequences for cell fate. Autophagy is essential for cell survival during stress and accordingly, we would predict PTPsigma suppression to enhance autophagy-mediated survival (Meijer and Codogno 2004). The ability to increase autophagy could potentially provide therapeutic benefit in the treatment of several diseases, notably those involving neurodegeneration (Hara, Nakamura et al. 2006; Komatsu, Waguri et al. 2006). With this in mind, we utilized an in silico screening approach, outlined in Chapter 3, to identify small molecule inhibitors of PTPsigma. If selective, these compounds could prove to be useful molecular probes in the study of autophagy.Finally, we aimed to capture a comprehensive understanding of autophagy dynamics through mathematical modeling. To this end, we utilized kinetic live-cell microscopy to develop an accurate and predictive model of autophagy vesicle dynamics, detailed in Chapter 4. This model, and its framework for a more large-scale autophagy network, can be used to generate novel hypotheses and be implemented as a tool to test experimentally-derived hypotheses, such as those presented for PTPsigma.

Description based on online resource; title from PDF t.p. (ProQuest, viewed Jan. 26,2012).

Advisors/Committee Members: MacKeigan, Jeffrey P, Esselman, Walter J, LaPres, John J, Miranti, Cindy K, Chan, Christina.

Subjects/Keywords: Lipid membranes; Lipids; Lipoproteins; Phosphoprotein phosphatases; Cellular signal transduction; Cytology – Research; Cellular biology

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APA (6^th Edition):

Martin, K. R. (2011). An integrative approach to understanding PI(3)P signaling and autophagy. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:649

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Martin, Katie Renee. “An integrative approach to understanding PI(3)P signaling and autophagy.” 2011. Thesis, Michigan State University. Accessed April 15, 2021. http://etd.lib.msu.edu/islandora/object/etd:649.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Martin, Katie Renee. “An integrative approach to understanding PI(3)P signaling and autophagy.” 2011. Web. 15 Apr 2021.

Vancouver:

Martin KR. An integrative approach to understanding PI(3)P signaling and autophagy. [Internet] [Thesis]. Michigan State University; 2011. [cited 2021 Apr 15]. Available from: http://etd.lib.msu.edu/islandora/object/etd:649.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Martin KR. An integrative approach to understanding PI(3)P signaling and autophagy. [Thesis]. Michigan State University; 2011. Available from: http://etd.lib.msu.edu/islandora/object/etd:649

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Missouri – Columbia

26. Ding, Zhaofeng, 1978-. Kinase-interacting FHA domain of kinase associated protein phosphatase : phosphopeptide interactions and NMR-detected dynamics.

Degree: PhD, 2007, University of Missouri – Columbia

URL: http://hdl.handle.net/10355/4729

► FHA domains are phosphoThr recognition modules found in diverse signaling proteins. Kinase-associated protein phosphatase (KAPP) from Arabidopsis employs its FHA domain in its negative regulation… (more)

Subjects/Keywords: Forkhead-associated domain.; Forkhead-associated domain; Plants – Development; Phosphoprotein phosphatases; Protein kinases; Nuclear magnetic resonance; Cellular signal transduction; Mutagenesis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ding, Zhaofeng, 1. (2007). Kinase-interacting FHA domain of kinase associated protein phosphatase : phosphopeptide interactions and NMR-detected dynamics. (Doctoral Dissertation). University of Missouri – Columbia. Retrieved from http://hdl.handle.net/10355/4729

Chicago Manual of Style (16^th Edition):

Ding, Zhaofeng, 1978-. “Kinase-interacting FHA domain of kinase associated protein phosphatase : phosphopeptide interactions and NMR-detected dynamics.” 2007. Doctoral Dissertation, University of Missouri – Columbia. Accessed April 15, 2021. http://hdl.handle.net/10355/4729.

MLA Handbook (7^th Edition):

Ding, Zhaofeng, 1978-. “Kinase-interacting FHA domain of kinase associated protein phosphatase : phosphopeptide interactions and NMR-detected dynamics.” 2007. Web. 15 Apr 2021.

Vancouver:

Ding, Zhaofeng 1. Kinase-interacting FHA domain of kinase associated protein phosphatase : phosphopeptide interactions and NMR-detected dynamics. [Internet] [Doctoral dissertation]. University of Missouri – Columbia; 2007. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/10355/4729.

Council of Science Editors:

Ding, Zhaofeng 1. Kinase-interacting FHA domain of kinase associated protein phosphatase : phosphopeptide interactions and NMR-detected dynamics. [Doctoral Dissertation]. University of Missouri – Columbia; 2007. Available from: http://hdl.handle.net/10355/4729

University of Missouri – Columbia

27. Ghosh, Anuprita, 1978-. Role of Sds22 in the regulation of protein phosphatase-1 in Saccharomyces cerevisiae.

Degree: 2009, University of Missouri – Columbia

URL: http://hdl.handle.net/10355/8793

► [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] GLC7 encodes the catalytic subunit of protein phosphatase 1 (PP1) in the budding yeast… (more)

▼ [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] GLC7 encodes the catalytic subunit of protein phosphatase 1 (PP1) in the budding yeast Saccharomyces cerevisiae. Glc7 binds different regulatory subunits which specifically localize and also specify the substrates of the catalytic subunit. Sds22 is an essential regulator of Glc7. Sds22 binds and localizes Glc7 in the nucleus. The substrates of Glc7-Sds22 are thought to be the kinetochore proteins. The mode of regulation of Glc7 by Sds22 is not exactly known. The objective of this research was to further elucidate regulation of PP1 by Sds22. We hypothesized that in addition to binding and localizing Glc7 in the nucleus, Sds22 binds the proteins/ substrates essential for the Glc7-Sds22 function. First, we characterized STS, a potential bypass suppressor of Sds22. The data suggest that STS might be a duplication of chromosome XI that has SDS22. The duplication of chromosome could have resulted from overexpression of Glc7 in sds22 strain. Second, we confirmed binding of seven different GST-fusion proteins (Kog1, Nop6, Net, Rvb1, Rvb2, Snf4 and YGR130C) to Sds22 by co-immunoprecipitation assay. We discovered that Bub3, a mitotic spindle assembly checkpoint protein, also binds Sds22, which was not known previously. In order to determine whether the binding of Glc7 is required for Sds22 to suppress ipl1 temperature sensitivity, we made different missense and deletion mutations in the leucine rich repeats (LRRs) of SDS22. The stable missense and LRR deletion Sds22 mutant proteins continued to bind Glc7, though with reduced efficiency compared to the wild-type Sds22 protein. The mutant Sds22 proteins that have reduced affinity for Glc7 suppressed ipl1 with reduced efficiency. Collectively, our results suggest that Sds22 has more functions than just binding and localizing Glc7 in the nucleus. Sds22 binds proteins in addition to binding Glc7 and requires both the binding of Glc7 and essential proteins/ substrates for the full or best suppression of ipl1-1. Advisors/Committee Members: Cannon, John Francis, 1956- (advisor).

Subjects/Keywords: Saccharomyces cerevisiae Proteins – metabolism; Protein Phosphotase 1 – metabolism; Phosphoprotein Phosphatases – metabolism; Saccharomyces cerevisiae Proteins – genetics; Saccharomyces cervisiae – enzymology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ghosh, Anuprita, 1. (2009). Role of Sds22 in the regulation of protein phosphatase-1 in Saccharomyces cerevisiae. (Thesis). University of Missouri – Columbia. Retrieved from http://hdl.handle.net/10355/8793

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ghosh, Anuprita, 1978-. “Role of Sds22 in the regulation of protein phosphatase-1 in Saccharomyces cerevisiae.” 2009. Thesis, University of Missouri – Columbia. Accessed April 15, 2021. http://hdl.handle.net/10355/8793.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ghosh, Anuprita, 1978-. “Role of Sds22 in the regulation of protein phosphatase-1 in Saccharomyces cerevisiae.” 2009. Web. 15 Apr 2021.

Vancouver:

Ghosh, Anuprita 1. Role of Sds22 in the regulation of protein phosphatase-1 in Saccharomyces cerevisiae. [Internet] [Thesis]. University of Missouri – Columbia; 2009. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/10355/8793.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ghosh, Anuprita 1. Role of Sds22 in the regulation of protein phosphatase-1 in Saccharomyces cerevisiae. [Thesis]. University of Missouri – Columbia; 2009. Available from: http://hdl.handle.net/10355/8793

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

IUPUI

28. Widau, Ryan Cole. Protein phosphatase 2A (PP2A) holoenzymes regulate death associated protein kinase (DAPK) in ceramide-induced anoikis.

Degree: 2010, IUPUI

URL: http://hdl.handle.net/1805/2131

►

Indiana University-Purdue University Indianapolis (IUPUI)

Modulation of sphingolipid-induced apoptosis is a potential mechanism to enhance the effectiveness of chemotherapeutic drugs. Ceramide is a pleiotropic, sphingolipid… (more)

▼

Indiana University-Purdue University Indianapolis (IUPUI)

Modulation of sphingolipid-induced apoptosis is a potential mechanism to enhance the effectiveness of chemotherapeutic drugs. Ceramide is a pleiotropic, sphingolipid produced by cells in response to inflammatory cytokines, chemotherapeutic drugs and ionizing radiation. Ceramide is a potent activator of protein phosphatases, including protein phosphatase 2A (PP2A) leading to dephosphorylation of substrates important in regulating mitochondrial dysfunction and apoptosis. Previous studies demonstrated that death associated protein kinase (DAPK) plays a role in ceramide-induced apoptosis via an unknown mechanism. The tumor suppressor DAPK is a calcium/calmodulin regulated serine/threonine kinase with an important role in regulating cytoskeletal dynamics. Auto-phosphorylation within the calmodulin-binding domain at serine308 inhibits DAPK catalytic activity. Dephosphorylation of serine308 by a hitherto unknown phosphatase enhances kinase activity and proteasomal mediated degradation of DAPK. In these studies, using a tandem affinity purification procedure coupled to LC-MS/MS, we have identified two holoenzyme forms of PP2A as DAPK interacting proteins. These phosphatase holoenzymes dephosphorylate DAPK at Serine308 in vitro and in vivo resulting in enhanced kinase activity of DAPK. The enzymatic activity of PP2A also negatively regulates DAPK protein levels by enhancing proteasomal-mediated degradation of the kinase, as a means to attenuate prolonged kinase activation. These studies also demonstrate that ceramide causes a caspase-independent cell detachment in HeLa cells, a human cervical carcinoma cell line. Subsequent to detachment, these cells underwent caspase-dependent apoptosis due to lack of adhesion, termed anoikis. Overexpression of wild type DAPK induced cell rounding and detachment similar to cells treated with ceramide; however, this effect was not observed following expression of a phosphorylation mutant, S308E DAPK. Finally, the endogenous interaction of DAPK and PP2A was determined to be required for ceramide-induced cell detachment and anoikis. Together these studies have provided exciting and essential new data regarding the mechanisms of cell adhesion and anoikis. These results define a novel cellular pathway initiated by ceramide-mediated activation of PP2A and DAPK to regulate inside-out signaling and promote anoikis.

Advisors/Committee Members: Gallagher, Patricia J., Herring, B. Paul, Rhodes, Simon J., Skalnik, David Gordon.

Subjects/Keywords: SPHINGOLIPID; ADHESION; CERAMIDE; APOPTOSIS; ANOIKIS; PP2A; PROTEIN PHOSPHATASE 2A; DAPK; DEATH ASSOCIATED PROTEIN KINASE; Apoptosis; Ceramides; Sphingolipids; Phosphoprotein phosphatases; Protein kinases; Chemotherapy – Effectiveness

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APA (6^th Edition):

Widau, R. C. (2010). Protein phosphatase 2A (PP2A) holoenzymes regulate death associated protein kinase (DAPK) in ceramide-induced anoikis. (Thesis). IUPUI. Retrieved from http://hdl.handle.net/1805/2131

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Widau, Ryan Cole. “Protein phosphatase 2A (PP2A) holoenzymes regulate death associated protein kinase (DAPK) in ceramide-induced anoikis.” 2010. Thesis, IUPUI. Accessed April 15, 2021. http://hdl.handle.net/1805/2131.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Widau, Ryan Cole. “Protein phosphatase 2A (PP2A) holoenzymes regulate death associated protein kinase (DAPK) in ceramide-induced anoikis.” 2010. Web. 15 Apr 2021.

Vancouver:

Widau RC. Protein phosphatase 2A (PP2A) holoenzymes regulate death associated protein kinase (DAPK) in ceramide-induced anoikis. [Internet] [Thesis]. IUPUI; 2010. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/1805/2131.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Widau RC. Protein phosphatase 2A (PP2A) holoenzymes regulate death associated protein kinase (DAPK) in ceramide-induced anoikis. [Thesis]. IUPUI; 2010. Available from: http://hdl.handle.net/1805/2131

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Missouri – Columbia

29. Aikins, Anthea Anita, 1982-. Regulation of Pcl6 and Pcl7 in a Glc7 pathway in Saccharomyces cerevisiae.

Degree: 2010, University of Missouri – Columbia

URL: https://doi.org/10.32469/10355/10291

► GLC7 is an essential gene in Saccharomyces cerevisiae that encodes the catalytic subunit of protein phosphatase-1. Glc7 is conditionally activated by phospho-Glc8, which is phosphorylated… (more)

Subjects/Keywords: Saccharomyces cerevisiae – Genetics; Saccharomyces cerevisiae – Metabolism; Phosphoprotein phosphatases – Metabolism – Genetic aspects; Cyclins – Metabolism – Genetic aspects; DNA damage; DNA repair; Saccharomyces cerevisiae – metabolism; Saccharomyces cerevisiae – enzymology; Protein Phosphatase 1 – metabolism; Protein Phosphatase 1 – genetics; Saccharomyces cerevisiae Proteins – metabolism; Saccharomyces cerevisiae Proteins – genetics; Cyclins – metabolism; Cyclins – genetics; DNA damage; DNA repair

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Aikins, Anthea Anita, 1. (2010). Regulation of Pcl6 and Pcl7 in a Glc7 pathway in Saccharomyces cerevisiae. (Thesis). University of Missouri – Columbia. Retrieved from https://doi.org/10.32469/10355/10291

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Aikins, Anthea Anita, 1982-. “Regulation of Pcl6 and Pcl7 in a Glc7 pathway in Saccharomyces cerevisiae.” 2010. Thesis, University of Missouri – Columbia. Accessed April 15, 2021. https://doi.org/10.32469/10355/10291.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Aikins, Anthea Anita, 1982-. “Regulation of Pcl6 and Pcl7 in a Glc7 pathway in Saccharomyces cerevisiae.” 2010. Web. 15 Apr 2021.

Vancouver:

Aikins, Anthea Anita 1. Regulation of Pcl6 and Pcl7 in a Glc7 pathway in Saccharomyces cerevisiae. [Internet] [Thesis]. University of Missouri – Columbia; 2010. [cited 2021 Apr 15]. Available from: https://doi.org/10.32469/10355/10291.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Aikins, Anthea Anita 1. Regulation of Pcl6 and Pcl7 in a Glc7 pathway in Saccharomyces cerevisiae. [Thesis]. University of Missouri – Columbia; 2010. Available from: https://doi.org/10.32469/10355/10291

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Missouri – Columbia

30. Aikins, Anthea Anita, 1982-. Regulation of Pcl6 and Pcl7 in a Glc7 pathway in Saccharomyces cerevisiae.

Degree: 2010, University of Missouri – Columbia

URL: http://hdl.handle.net/10355/10291

► GLC7 is an essential gene in Saccharomyces cerevisiae that encodes the catalytic subunit of protein phosphatase-1. Glc7 is conditionally activated by phospho-Glc8, which is phosphorylated… (more)

Subjects/Keywords: Saccharomyces cerevisiae – Genetics; Saccharomyces cerevisiae – Metabolism; Phosphoprotein phosphatases – Metabolism – Genetic aspects; Cyclins – Metabolism – Genetic aspects; DNA damage; DNA repair; Saccharomyces cerevisiae – metabolism; Saccharomyces cerevisiae – enzymology; Protein Phosphatase 1 – metabolism; Protein Phosphatase 1 – genetics; Saccharomyces cerevisiae Proteins – metabolism; Saccharomyces cerevisiae Proteins – genetics; Cyclins – metabolism; Cyclins – genetics; DNA damage; DNA repair

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Aikins, Anthea Anita, 1. (2010). Regulation of Pcl6 and Pcl7 in a Glc7 pathway in Saccharomyces cerevisiae. (Thesis). University of Missouri – Columbia. Retrieved from http://hdl.handle.net/10355/10291

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Aikins, Anthea Anita, 1982-. “Regulation of Pcl6 and Pcl7 in a Glc7 pathway in Saccharomyces cerevisiae.” 2010. Thesis, University of Missouri – Columbia. Accessed April 15, 2021. http://hdl.handle.net/10355/10291.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Aikins, Anthea Anita, 1982-. “Regulation of Pcl6 and Pcl7 in a Glc7 pathway in Saccharomyces cerevisiae.” 2010. Web. 15 Apr 2021.

Vancouver:

Aikins, Anthea Anita 1. Regulation of Pcl6 and Pcl7 in a Glc7 pathway in Saccharomyces cerevisiae. [Internet] [Thesis]. University of Missouri – Columbia; 2010. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/10355/10291.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Aikins, Anthea Anita 1. Regulation of Pcl6 and Pcl7 in a Glc7 pathway in Saccharomyces cerevisiae. [Thesis]. University of Missouri – Columbia; 2010. Available from: http://hdl.handle.net/10355/10291

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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