Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

You searched for subject:(Phospholipase D Signalling). One record found.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters


University of Alberta

1. Capatos, Dora. Role of Lipins in Regulating Phospholipase D Signalling.

Degree: MS, Department of Biochemistry, 2013, University of Alberta

A potential therapeutic target in cancer is phospholipase D (PLD), which converts phosphatidylcholine into phosphatidic acid, a lipid second messenger in cell signalling. The lipid phosphate phosphatases are considered to convert PLD-generated phosphatidic acid to diacylglycerol. However, the lipid phosphate phosphatases are integral membrane proteins with catalytic sites on the extracellular or lumenal sides of membranes whereas phosphatidic acid accumulates on the cytosolic leaflet of membranes. The other enzymes that dephosphorylate phosphatidic acid, the lipins, are cytosolic proteins that translocate to membranes. This project investigated whether lipin-1 and lipin-2 regulate PLD signalling. The results show that phosphatidic acid accumulation in breast cancer cells resulted from PLD1 and PLD2 activation and activity of calcium-dependent diacylglycerol kinases. Depletion of lipin-1 did not affect PLD-dependent phosphatidic acid accumulation in fibroblasts. This work provides the first evidence that increased phosphatidic acid phosphatase activity of lipins is associated with membranes in response to PLD stimulation.

Subjects/Keywords: Phospholipase D Signalling; Lipin; Phospholipase D

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Capatos, D. (2013). Role of Lipins in Regulating Phospholipase D Signalling. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/00000130x

Chicago Manual of Style (16th Edition):

Capatos, Dora. “Role of Lipins in Regulating Phospholipase D Signalling.” 2013. Masters Thesis, University of Alberta. Accessed December 12, 2019. https://era.library.ualberta.ca/files/00000130x.

MLA Handbook (7th Edition):

Capatos, Dora. “Role of Lipins in Regulating Phospholipase D Signalling.” 2013. Web. 12 Dec 2019.

Vancouver:

Capatos D. Role of Lipins in Regulating Phospholipase D Signalling. [Internet] [Masters thesis]. University of Alberta; 2013. [cited 2019 Dec 12]. Available from: https://era.library.ualberta.ca/files/00000130x.

Council of Science Editors:

Capatos D. Role of Lipins in Regulating Phospholipase D Signalling. [Masters Thesis]. University of Alberta; 2013. Available from: https://era.library.ualberta.ca/files/00000130x

.