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You searched for subject:(Pharmacokinetics AND Pharmacodynamics of Fentanyl in Alpacas after Intravenous AND Transdermal Administration). One record found.

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The Ohio State University

1. Lovasz, Michael F. Pharmacokinetics and Pharmacodynamics of Fentanyl in Alpacas after Intravenous and Transdermal Administration.

Degree: MS, Veterinary Clinical Sciences, 2016, The Ohio State University

The objective of the study reported here was to determine pharmacokinetics and pharmacodynamics of fentanyl in alpacas after intravenous (IV) and transdermal (TD) administration.Fentanyl was administered IV (2 mcg/kg) or TD (2 mcg/kg/hr) in 6 adult alpacas. Samples of venous blood were obtained at predetermined intervals for 24 hours after IV and 96 hours after TD administration to determine plasma concentrations using liquid chromatography-mass spectrometry. Sedation score, HR, RR, and the responses to thermal and mechanical nociception were assessed at each time point. Maximum plasma concentration (Cmax) of fentanyl was 4.6 +/- 1.8 ng/mL after IV administration, clearance was 921 +/- 189 mL/kg/hr, volume of distribution was 4.3 +/-1.8 L/kg and elimination half-life was 3.1 hours (range 1.87-7.2 hours). Mild sedation occurred within 5 minutes of IV administration and lasted up to 45 minutes. Apparent excitement occurred in three alpacas following IV fentanyl administration. Limb mechanical threshold and abdominal algometry were significantly increased from baseline at 15 minutes and 45 minutes, respectively. Mean maximum plasma fentanyl concentration was 1.3+/- 0.8 ng/mL, mean residence time was 42 +/- 8 hours, and elimination half-life was 16.5 hours (range 10-22 hours) after TD administration. Sedation was mild in three alpacas following TD fentanyl, peaked by 24 hours and lasted up to 60 hours. Plasma fentanyl concentrations peaked and fell rapidly after IV administration. Uptake of TD fentanyl was absorption dependent, but nearly complete. The behavioral responses to IV fentanyl were inconsistent. Advisors/Committee Members: Bednarski, Richard (Advisor).

Subjects/Keywords: Veterinary Services; Pharmacokinetics and Pharmacodynamics of Fentanyl in Alpacas after Intravenous and Transdermal Administration

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APA (6th Edition):

Lovasz, M. F. (2016). Pharmacokinetics and Pharmacodynamics of Fentanyl in Alpacas after Intravenous and Transdermal Administration. (Masters Thesis). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1461173885

Chicago Manual of Style (16th Edition):

Lovasz, Michael F. “Pharmacokinetics and Pharmacodynamics of Fentanyl in Alpacas after Intravenous and Transdermal Administration.” 2016. Masters Thesis, The Ohio State University. Accessed January 18, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461173885.

MLA Handbook (7th Edition):

Lovasz, Michael F. “Pharmacokinetics and Pharmacodynamics of Fentanyl in Alpacas after Intravenous and Transdermal Administration.” 2016. Web. 18 Jan 2021.

Vancouver:

Lovasz MF. Pharmacokinetics and Pharmacodynamics of Fentanyl in Alpacas after Intravenous and Transdermal Administration. [Internet] [Masters thesis]. The Ohio State University; 2016. [cited 2021 Jan 18]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1461173885.

Council of Science Editors:

Lovasz MF. Pharmacokinetics and Pharmacodynamics of Fentanyl in Alpacas after Intravenous and Transdermal Administration. [Masters Thesis]. The Ohio State University; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1461173885

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