subject:(Pharmaceutical sciences)

University of Washington

1. Tung, Amy. Characterizing Healthcare Utilization, Direct Costs, and Comorbidities Associated with Interstitial Cystitis: A Retrospective Claims Analysis.

Degree: 2016, University of Washington

URL: http://hdl.handle.net/1773/36463

► Introduction Interstitial Cystitis (IC) is a debilitating condition that affects up to five percent of the United States (US) population.1 The condition is characterized by… (more)

▼ Introduction Interstitial Cystitis (IC) is a debilitating condition that affects up to five percent of the United States (US) population.1 The condition is characterized by bladder pain, urinary urgency and frequency, and in some patients, bladder lesions called Hunner’s Lesions (HL). Patients with HL experience a clinical course distinctly different from patients without HL.2 Prior research describing the burden of IC is outdated and lacks HL-level detail. This study aims to characterize healthcare utilization, direct costs, and comorbidities associated with IC, and among IC patients, elucidate differences between those with and without HL. Methods A retrospective analysis was conducted using healthcare claims from the Truven Health MarketScan® Research Databases. Adults with an incident IC diagnosis between 2009 and 2014 were identified and matched to non-IC patients on age, gender, and geographic region. Healthcare utilization, direct costs, and comorbidities during the first 12 months after diagnosis were compared between the two groups, as well as between IC subgroups with and without HL. Results IC patients (n=24,836) were predominantly (92%) female, with a mean age of 49.0 (SD = 15.3) years. IC patients utilized significantly more healthcare resources across all categories compared to non-IC patients. On average, having IC was associated with 6,798 higher total healthcare costs than not having IC (95% CI: 6,253, 7,343), with outpatient costs contributing to 71% of the difference, after adjusting for baseline age, gender, region, insurance type, plan type, and CCI. The odds of developing IC-related comorbidities were 2.61 times greater in IC patients compared to non-IC patients (95% CI: 2.52, 2.70), adjusting for baseline age, sex, region, and CCI. Among IC patients, the HL subgroup (n=292) utilized more healthcare resources, and having HL was associated with 6,486 higher total healthcare costs compared to not having HL (95% CI: 3,497, 9,475) after adjusting for baseline age, gender, region, insurance type, and plan type. Conclusion Our findings suggest that patients with IC have significantly higher healthcare utilization, costs, and comorbidities compared to non-IC patients. This economic burden is further amplified in those with HL. Advisors/Committee Members: Devine, Emily B (advisor).

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APA (6^th Edition):

Tung, A. (2016). Characterizing Healthcare Utilization, Direct Costs, and Comorbidities Associated with Interstitial Cystitis: A Retrospective Claims Analysis. (Thesis). University of Washington. Retrieved from http://hdl.handle.net/1773/36463

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tung, Amy. “Characterizing Healthcare Utilization, Direct Costs, and Comorbidities Associated with Interstitial Cystitis: A Retrospective Claims Analysis.” 2016. Thesis, University of Washington. Accessed March 02, 2021. http://hdl.handle.net/1773/36463.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tung, Amy. “Characterizing Healthcare Utilization, Direct Costs, and Comorbidities Associated with Interstitial Cystitis: A Retrospective Claims Analysis.” 2016. Web. 02 Mar 2021.

Vancouver:

Tung A. Characterizing Healthcare Utilization, Direct Costs, and Comorbidities Associated with Interstitial Cystitis: A Retrospective Claims Analysis. [Internet] [Thesis]. University of Washington; 2016. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1773/36463.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tung A. Characterizing Healthcare Utilization, Direct Costs, and Comorbidities Associated with Interstitial Cystitis: A Retrospective Claims Analysis. [Thesis]. University of Washington; 2016. Available from: http://hdl.handle.net/1773/36463

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Washington

2. Hopkins, Thomas D. Surgical Costs Associated with the Treatment of Uterine Fibroids.

Degree: 2020, University of Washington

URL: http://hdl.handle.net/1773/45077

► Introduction Uterine fibroids, or leiomyomas, are benign tumors that arise from smooth muscle tissue in the uterine cavity and lining. The true prevalence of uterine… (more)

▼ Introduction Uterine fibroids, or leiomyomas, are benign tumors that arise from smooth muscle tissue in the uterine cavity and lining. The true prevalence of uterine fibroids is difficult to determine due to only symptomatic women presenting for treatment, however, a large scale study found that the self-reported prevalence in the United States (US) is about 6.9% and the age-standardized incidence rates of fibroids confirmed by ultrasound or hysterectomy were 9.2 per 1,000 person-years overall. There are many pharmacologic treatments that are approved and used in practice for the treatment of uterine fibroids, including: hormone contraceptives, gonadotropin-releasing hormone (GnRH) agonists, GnRH antagonists, among other less used agents. The mainstay of curative therapies are surgical procedures with hysterectomies being the true curative option. Therefore, the focus of this thesis was on the all cause long-term surgical procedure costs associated with each of the procedures. The surgical procedures addressed and analyzed in this study were open and laparoscopic hysterectomies, open and laparoscopic myomectomies, uterine artery embolization, magnetic resonance-guided focused ultrasound (MRgFUS), and endometrial ablation. There are differential rates in recurrence of uterine fibroids among the surgery types that could also require a re-intervention by a physician. Because of this, this study is designed to compare the costs among the different surgery types with different risks of re-intervention rates. Objective The primary objective of this study was to describe and compare the long-term all cause direct costs associated with subjects’ first surgical procedure for uterine fibroids of the seven surgical interventions or interventional radiology procedures. Methods A retrospective cohort study design was utilized to compare the long-term all cause costs associated with the seven major surgical types for the treatment of uterine fibroids in a large database with claims for the commercially insured population of the United States. Patients were described based on their first surgical procedure for the treatment of uterine fibroids. Multivariate regression analysis was utilized to determine the statistical significance of the differences of costs for the different surgical cohorts. All cause total costs, all cause medical costs, all cause pharmacy costs, all cause outpatient costs, and all cause inpatient costs were collected for the seven surgical cohorts over a nine-year time frame from 2008 through 2016. All cause total costs were the sum of all cause medical, all cause pharmacy, all cause outpatient, and all cause inpatient costs. Results 81,910 women were included in the study: total abdominal hysterectomy (21,796), laparoscopic hysterectomy (16,206), total abdominal myomectomy (4,889), laparoscopic myomectomy (25,504), uterine artery embolization (1,521), endometrial ablation (11,890), MRgFUS (105). The surgical cohort with the highest all cause total costs was the MRgFUS cohort ($90,992), followed endometrial… Advisors/Committee Members: Hansen, Ryan (advisor), Barthold, Douglas (advisor).

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hopkins, T. D. (2020). Surgical Costs Associated with the Treatment of Uterine Fibroids. (Thesis). University of Washington. Retrieved from http://hdl.handle.net/1773/45077

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hopkins, Thomas D. “Surgical Costs Associated with the Treatment of Uterine Fibroids.” 2020. Thesis, University of Washington. Accessed March 02, 2021. http://hdl.handle.net/1773/45077.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hopkins, Thomas D. “Surgical Costs Associated with the Treatment of Uterine Fibroids.” 2020. Web. 02 Mar 2021.

Vancouver:

Hopkins TD. Surgical Costs Associated with the Treatment of Uterine Fibroids. [Internet] [Thesis]. University of Washington; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1773/45077.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hopkins TD. Surgical Costs Associated with the Treatment of Uterine Fibroids. [Thesis]. University of Washington; 2020. Available from: http://hdl.handle.net/1773/45077

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Washington

3. Lee, Jae Hyun. Geographic Variation in the Use of Triptans and Opioids for the Acute Treatment of Migraine Attacks.

Degree: 2020, University of Washington

URL: http://hdl.handle.net/1773/45803

► BACKGROUND: Clinical guidelines and published literature suggest that opioids should be used sparingly or avoided in patients with acute migraine due to a lack of… (more)

▼ BACKGROUND: Clinical guidelines and published literature suggest that opioids should be used sparingly or avoided in patients with acute migraine due to a lack of evidence of their effectiveness, association with disease progression, and risk of dependence. Triptans are the first line option for the acute treatment of moderate to severe migraine attacks. Despite recommendations, published research suggests that opioids are prescribed more frequently than triptans (53% vs 48%) among patients with migraine. Previous studies have been published for other chronic disease states showing that geographic variation plays a role in prescribing patterns in the United States (US). Moreover, 26 states have passed legislation that limit the prescribing or dispensing of opioids for acute pain. Every state in the Northeast has currently implemented these laws. In addition, the Northeast has the greatest number of headache subspecialists and primary care physicians per capita Yet, the level geographic differences in prescribing patterns, among triptan and opioid users for patients with migraine, has not been elucidated. OBJECTIVE: To assess the geographic variations in triptan and opioid prescribing patterns for patients with migraine. METHODS: We conducted a retrospective cohort analysis using claims data from the IBMÂ® MarketScanÂ® Commercial and Medicare Supplemental databases from January 1, 2016 to December 31, 2018. The target population was adults with migraine who had a migraine-related medical encounter in 2017 with a confirmatory encounter taking place between 31 to 365 days after the initial claim. Baseline characteristics were assessed during the 12-month pre-index period. The 12-month follow-up period was used to assess the outcomes of interest, triptan and opioid utilization, stratified by the four Census-Bureau designated regions: Northeast, Midwest, South, and West. State-level descriptive geographic heat maps were created to depict the patterns of triptan and opioid use in the US. Logistic regression models were used to estimate the binary outcomes of any triptan or opioid use in the follow-up period. Zero-truncated Negative binomial regression models were used to estimate the rate of triptan and opioid use among users in the form of incidence rate ratios (IRR). These analyses were adjusted for age, sex, health plan, presence of chronic migraine, and Elixhauser comorbidity scores. RESULTS: A total of 147,700 patients met the study inclusion criteria. The mean age was 45 and 84% of the patients were female. The prevalence of chronic migraine in the study population was 13% and the mean (SD) comorbidity score was 1.5 (1.7). In the follow-up period, the mean (SD) number of triptan claims for the Northeast, Midwest, South, and West regions were 2.36 (4.05), 2.50 (4.15), 2.60 (4.27), and 2.66 (4.32) respectively. The mean (SD) number of opioid claims for the same regions were 1.50 (4.34), 2.20 (5.00), 2.33 (5.13), and 2.35 (5.45), respectively. Compared to the Northeast, a patient with migraine was more likely to be a… Advisors/Committee Members: Devine, Beth (advisor).

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lee, J. H. (2020). Geographic Variation in the Use of Triptans and Opioids for the Acute Treatment of Migraine Attacks. (Thesis). University of Washington. Retrieved from http://hdl.handle.net/1773/45803

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lee, Jae Hyun. “Geographic Variation in the Use of Triptans and Opioids for the Acute Treatment of Migraine Attacks.” 2020. Thesis, University of Washington. Accessed March 02, 2021. http://hdl.handle.net/1773/45803.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lee, Jae Hyun. “Geographic Variation in the Use of Triptans and Opioids for the Acute Treatment of Migraine Attacks.” 2020. Web. 02 Mar 2021.

Vancouver:

Lee JH. Geographic Variation in the Use of Triptans and Opioids for the Acute Treatment of Migraine Attacks. [Internet] [Thesis]. University of Washington; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1773/45803.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lee JH. Geographic Variation in the Use of Triptans and Opioids for the Acute Treatment of Migraine Attacks. [Thesis]. University of Washington; 2020. Available from: http://hdl.handle.net/1773/45803

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Yadlapalli, Jai Shankar K. Preclinical evaluation of the 6-O-sulfate ester of morphine for the treatment of multimodal acute and chronic pain.

Degree: 2015, University of Arkansas for Medical Sciences

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3721351

► Chronic pain is a huge economic burden and a devastating complication requiring therapeutic interventions. This dissertation evaluated the analgesic potency, efficacy, tolerance and cross-tolerance… (more)

▼ Chronic pain is a huge economic burden and a devastating complication requiring therapeutic interventions. This dissertation evaluated the analgesic potency, efficacy, tolerance and cross-tolerance profile of morphine and its ester derivative, morphine-6-O-sulfate (M6S) in a rat model of diabetic neuropathy, and in normal rats utilizing a multimodal pain domain approach (e.g., burning pain, pricking pain, and deep muscle pain). Diabetes was induced in male Sprague-Dawley rats with streptozotocin, 65mg/kg (intraperitoneally). Hot water tail-flick latency, paw pressure, pinprick sensitivity and hot plate withdrawal thresholds (HTL, PPT, PST and HPT) were measured at various time points and doses after i.p. injection (N=6) on days 1, 3, 7, 9, 12, 19, 25 and 29 of treatment in both normal and diabetic rats. Affinity binding studies, GTPγ S assays and intracellular cAMP assays were performed in Chinese hamster ovary cells transfected with human mu (μ) - or delta (δ)-opioid receptors (N=5). HPLC-DAD stability studies were performed in vitro in various pH buffers and biological fluids (N=4). Pharmacokinetic parameters for M6S were studied using intravenous (1 mg/kg), intraperitoneal (i.p. 5.6, 10 mg/kg) and oral routes (10, 30 mg/kg) of drug administration (N=4 to 7 for each dose). Compared to morphine, in diabetic animals, M6S was 12-fold more potent in the HPT test (ED₅₀ M6S = 1.1 ± 0.02 μmol/kg Vs ED₅₀ MOR=12.1 ± 1.8 μmol/kg; p< 0.05), and 20-times more potent in the HTL test (in diabetic rats, ED₅₀ M6S = 1.1 ± 0.02 μmol/kg Vs ED₅₀ MOR = 12.1 ± 1.8 μmol/kg; p< 0.001). In the PST test, M6S was 3-fold more potent than morphine in diabetic rats (ED₅₀ M6S = 6.9 ± 1.46 μmol/kg Vs ED₅₀ MOR = 16.2 ± 1.24 μmol/kg). Similar potency differences were also observed between morphine and M6S in normal rats. Diabetes caused a decrease in potency (about 3-5 fold) of morphine in the HPT and HTF tests and a loss of efficacy in the PST and PPT tests (4^th week of diabetes) without significantly effecting M6S potency and efficacy in all these tests. Furthermore, 9 vs. 28 days of chronic treatment were required for rats to become tolerant to morphine and M6S, respectively, in the HTF and HPT tests. M6S also sustained its potent analgesic effects in morphine-tolerant rats (i.e. no cross-tolerance) and demonstrated clinical potential as an opioid rotation drug in morphine-tolerant subjects. With no significant differences in binding, activation of GTPγ and inhibition of cAMP at the μ-opioid receptor, M6S activated G-proteins via δ-ORs more potently than morphine (e.g., M6S-ED₅₀ = 101 ± 41.6 nM; MOR-ED₅₀ = 785 ± 140 nM), and modulated adenylyl cyclase activity via δ-ORs in intact CHO-hDOR cells more potently than morphine (e.g., M6S-ED₅₀ = 55.1 ± 17.5 nM; MOR-ED₅₀…

Subjects/Keywords: Pharmaceutical sciences

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APA (6^th Edition):

Yadlapalli, J. S. K. (2015). Preclinical evaluation of the 6-O-sulfate ester of morphine for the treatment of multimodal acute and chronic pain. (Thesis). University of Arkansas for Medical Sciences. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3721351

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yadlapalli, Jai Shankar K. “Preclinical evaluation of the 6-O-sulfate ester of morphine for the treatment of multimodal acute and chronic pain.” 2015. Thesis, University of Arkansas for Medical Sciences. Accessed March 02, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3721351.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yadlapalli, Jai Shankar K. “Preclinical evaluation of the 6-O-sulfate ester of morphine for the treatment of multimodal acute and chronic pain.” 2015. Web. 02 Mar 2021.

Vancouver:

Yadlapalli JSK. Preclinical evaluation of the 6-O-sulfate ester of morphine for the treatment of multimodal acute and chronic pain. [Internet] [Thesis]. University of Arkansas for Medical Sciences; 2015. [cited 2021 Mar 02]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3721351.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yadlapalli JSK. Preclinical evaluation of the 6-O-sulfate ester of morphine for the treatment of multimodal acute and chronic pain. [Thesis]. University of Arkansas for Medical Sciences; 2015. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3721351

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Temple University

5. Lu, Zheng. DEVELOPMENT OF SUPERSATURATED MATRIX SYSTEMS FOR POORLY WATER-SOLUBLE COMPOUNDS BASED ON SPRAY-DRIED SOLID DISPERSIONS.

Degree: PhD, 2017, Temple University

URL: http://digital.library.temple.edu/u?/p245801coll10,463548

►

Pharmaceutical Sciences

The objective of this study was to design, develop and evaluate an amorphous solid dispersion (ASD)-loaded controlled release (CR) matrix system for poorly… (more)

▼

Pharmaceutical Sciences

The objective of this study was to design, develop and evaluate an amorphous solid dispersion (ASD)-loaded controlled release (CR) matrix system for poorly water-soluble drug in order to enhance its solubility and dissolution rate while maintaining the stability of the supersaturated state during and after dissolution. Two types of polymeric carriers, namely hydroxypropyl methylcellulose acetate succinate (HPMCAS) and copovidone S-630, were used in spary-dried dispersion (SDD) formulations. Weak acid drugs glipizide and gliclazide which tend to have limited solubility and dissolution rate were chosen as poorly soluble model compounds representing Class-II drugs according to the FDA adopted Biopharmaceutics Classification Scheme. The unique features of the hydrating CR matrix system consisting of amorphous drug dispersion that provides supersaturation and probable mechanisms to inhibit precipitation are investigated. SDD-loaded CR matrix tablets prepared in this study were based on use of automated spray dryer and compaction simulator with optimized process parameters in order to control the critical quality attributes (CQAs) of final formulations. A 3×4 full factorial design was conducted to understand the effect of drug loading level and polymer type on the performance of SDD products for both glipizide and gliclazide. Drug loading level and succinoyl content % of HPMCAS were identified as two critical factors for meeting goals set to achieve maximum concentration under non-sink condition referred to as Cmax. Compliance to Cmax limit is assured by selecting drug loading level and type of HPMCAS within design space. Spray-dried dispersions (SDDs) of glipizide and gliclazide were prepared using HPMCAS (H, M and L grades) and copovidone as amorphous matrix forming polymer in order to improve the solubility and dissolution rate of the drug. The SDDs appeared as a single amorphous phase with up to 60% drug loading level as revealed by X-ray powder diffraction (XRPD), modulated differential scanning calorimetry (mDSC) and scanning electron microscopy (SEM). Supersaturated micro-dissolution testing of SDD powders in fasted state simulated intestinal fluid showed prolonged supersaturation state (up to 180 minutes) with significant solubility increase relative to crystalline drug under same conditions. Moreover, plot of relative dissolution AUCs (AUC (SDD) /AUC (crystalline)) versus stable supersaturated concentration ratio (C180/Cmax) was provided as an appropriate formulation strategy for selecting SDDs with improved solubility and supersaturation stability. Selected SDDs were formulated into matrix tablet with rate-controlling hydrophilic polymer, hydroxypropylmethylcellulose (HPMC) and other excipients. Dissolution data based on standard USP paddle method indicated that SDD-loaded CR tablets provide stable supersaturated concentration within the hydrated matrix with increased rate and extent of drug dissolution. Co-existence of HPMCAS and HPMC within the hydrating matrix showed strong…

Advisors/Committee Members: Fassihi, Reza;, Canney, Daniel J., Ilies, Marc A., Wong, Ho-Lun, Hussain, Munir;.

Subjects/Keywords: Pharmaceutical sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lu, Z. (2017). DEVELOPMENT OF SUPERSATURATED MATRIX SYSTEMS FOR POORLY WATER-SOLUBLE COMPOUNDS BASED ON SPRAY-DRIED SOLID DISPERSIONS. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,463548

Chicago Manual of Style (16^th Edition):

Lu, Zheng. “DEVELOPMENT OF SUPERSATURATED MATRIX SYSTEMS FOR POORLY WATER-SOLUBLE COMPOUNDS BASED ON SPRAY-DRIED SOLID DISPERSIONS.” 2017. Doctoral Dissertation, Temple University. Accessed March 02, 2021. http://digital.library.temple.edu/u?/p245801coll10,463548.

MLA Handbook (7^th Edition):

Lu, Zheng. “DEVELOPMENT OF SUPERSATURATED MATRIX SYSTEMS FOR POORLY WATER-SOLUBLE COMPOUNDS BASED ON SPRAY-DRIED SOLID DISPERSIONS.” 2017. Web. 02 Mar 2021.

Vancouver:

Lu Z. DEVELOPMENT OF SUPERSATURATED MATRIX SYSTEMS FOR POORLY WATER-SOLUBLE COMPOUNDS BASED ON SPRAY-DRIED SOLID DISPERSIONS. [Internet] [Doctoral dissertation]. Temple University; 2017. [cited 2021 Mar 02]. Available from: http://digital.library.temple.edu/u?/p245801coll10,463548.

Council of Science Editors:

Lu Z. DEVELOPMENT OF SUPERSATURATED MATRIX SYSTEMS FOR POORLY WATER-SOLUBLE COMPOUNDS BASED ON SPRAY-DRIED SOLID DISPERSIONS. [Doctoral Dissertation]. Temple University; 2017. Available from: http://digital.library.temple.edu/u?/p245801coll10,463548

6. Pinto, Colin Andrew. Development and Characterization of Chitosan Crosslinked with Tripolyphosphate as a Sustained Release Agent in Tablets.

Degree: 2018, University of the Sciences in Philadelphia

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=10692987

► The ability of chitosan and tripolyphosphate to form an ionic crosslinked material and its effectiveness in sustained release formulations has been reported. However, key… (more)

▼ The ability of chitosan and tripolyphosphate to form an ionic crosslinked material and its effectiveness in sustained release formulations has been reported. However, key issues commonly observed with these formulations include inefficiencies and inaccuracies in the drug loading as well as an inability to achieve complete release of drug. Acetaminophen, as a model drug, was added to various chitosan-tripolyphosphate crosslinked powders to assess the sustained release characteristics when drug is added extragranularly as opposed to during the crosslinking process, which is the most common procedure for drug addition in prior literature. The influence of various process and formulation variables including chitosan concentration, chitosan:tripolyphosphate ratio, temperature, ionic strength, and pH was assessed. Design of experiments allowed the identification of factors and two factor interactions that have significant effects on particle size and size distribution, yield, zeta potential, true density, and drug release. Statistical model equations were successfully used to manufacture optimized chitosan-tripolyphosphate crosslinked powders with various properties for further evaluation. Analysis of the compressibility of the optimized powders revealed that the crosslinked powders had enhanced compression properties when compared to chitosan powder. Environmental scanning electron microscopy revealed a correlation between the rigidity and density of the powders and corresponding capabilities for enhanced sustained release. Analysis of the moisture sorption and desorption isotherms from dynamic vapor sorption analysis revealed various types and levels of water present and a correlation between the quantity of water internally absorbed during sorption and desorption and sustained release capability. Chitosan-tripolyphosphate crosslinked powder can be manufactured with optimized properties that allow desired sustained drug release profiles while simultaneously serving as the primary diluent for solid oral dosage forms.

Subjects/Keywords: Pharmaceutical sciences

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APA (6^th Edition):

Pinto, C. A. (2018). Development and Characterization of Chitosan Crosslinked with Tripolyphosphate as a Sustained Release Agent in Tablets. (Thesis). University of the Sciences in Philadelphia. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=10692987

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pinto, Colin Andrew. “Development and Characterization of Chitosan Crosslinked with Tripolyphosphate as a Sustained Release Agent in Tablets.” 2018. Thesis, University of the Sciences in Philadelphia. Accessed March 02, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=10692987.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pinto, Colin Andrew. “Development and Characterization of Chitosan Crosslinked with Tripolyphosphate as a Sustained Release Agent in Tablets.” 2018. Web. 02 Mar 2021.

Vancouver:

Pinto CA. Development and Characterization of Chitosan Crosslinked with Tripolyphosphate as a Sustained Release Agent in Tablets. [Internet] [Thesis]. University of the Sciences in Philadelphia; 2018. [cited 2021 Mar 02]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10692987.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pinto CA. Development and Characterization of Chitosan Crosslinked with Tripolyphosphate as a Sustained Release Agent in Tablets. [Thesis]. University of the Sciences in Philadelphia; 2018. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10692987

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

7. Abhyankar, Hrishita. Stabilization of the Amorphous Form of Poorly Soluble Drugs Using Ethyl Cellulose in Solid Dispersions.

Degree: 2018, University of the Sciences in Philadelphia

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=10692990

► The aims of this research was to evaluate the partial crystallinity of two BCS class II drugs (Ketoconazole and Chlorpropamide) when prepared as solid-dispersions… (more)

Subjects/Keywords: Pharmaceutical sciences

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APA (6^th Edition):

Abhyankar, H. (2018). Stabilization of the Amorphous Form of Poorly Soluble Drugs Using Ethyl Cellulose in Solid Dispersions. (Thesis). University of the Sciences in Philadelphia. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=10692990

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Abhyankar, Hrishita. “Stabilization of the Amorphous Form of Poorly Soluble Drugs Using Ethyl Cellulose in Solid Dispersions.” 2018. Thesis, University of the Sciences in Philadelphia. Accessed March 02, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=10692990.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Abhyankar, Hrishita. “Stabilization of the Amorphous Form of Poorly Soluble Drugs Using Ethyl Cellulose in Solid Dispersions.” 2018. Web. 02 Mar 2021.

Vancouver:

Abhyankar H. Stabilization of the Amorphous Form of Poorly Soluble Drugs Using Ethyl Cellulose in Solid Dispersions. [Internet] [Thesis]. University of the Sciences in Philadelphia; 2018. [cited 2021 Mar 02]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10692990.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Abhyankar H. Stabilization of the Amorphous Form of Poorly Soluble Drugs Using Ethyl Cellulose in Solid Dispersions. [Thesis]. University of the Sciences in Philadelphia; 2018. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10692990

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Irvine

8. Liu, Shuai. Towards an automated computational pipeline to guide drug lead optimization.

Degree: Pharmacological Sciences with a concentration in Pharmaceutical Sciences Ph, 2015, University of California – Irvine

URL: http://www.escholarship.org/uc/item/6t03g54n

► Molecular dynamics (MD) simulations are a promising tool to guide drug lead optimization. But because these tools are applied prospectively in drug discovery, blind tests… (more)

▼ Molecular dynamics (MD) simulations are a promising tool to guide drug lead optimization. But because these tools are applied prospectively in drug discovery, blind tests provide a key opportunity to validate these for real-world applications. I participated in the Statistical Assessment of Modeling of Proteins and Ligands (SAMPL) 3 blind test (chapter 1) in which I used different force fields to calculate hydration free energies and SAMPL4 (chapter 2) in which I analyzed pose prediction results from different groups using different computational tools. The results from these blind tests improve our understanding of the accuracy of current methods, allowing us to improve these methods. Large-scale applications of MD simulations to drug discovery have been few, partly because of the difficulty of planning and setting up the simulations. For example, alchemical relative free energy (RFE) calculations have relatively high accuracy in predicting differences in binding between drug lead compounds and new derivatives which are sought to improve binding potency. But setting up RFE calculations for large sets of compounds has required far too much manual intervention to be practical. I helped develop an algorithm, LOMAP (chapter3), to automatically plan and set up these calculations. Resulting applications indicated that it could successfully reduce the time of planning RFE calculations. But in this project, we assumed that relative free energy (RFE) calculations involving ring breaking will introduce substantial error, and we tried to avoid these calculations as much as possible. Later, we quantitatively calculated what these errors would be to confirm this (chapter4). Beside binding free energy calculations, MD simulations can also be used to predict solubilities. We used free energy calculations (chapter5) to calculate relative solubilities and compared the results with experiment and with results from more empirical chemical engineering methods. We found that our approach is more accurate, despite its straightforward nature. Long-term, we are working towards developing an automated pipeline to help guide key aspects of drug lead optimization. My work helped with understanding the accuracy of current techniques, improving their automation, and providing a new technique for predicting physical properties like solubilities.

Subjects/Keywords: Pharmaceutical sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Liu, S. (2015). Towards an automated computational pipeline to guide drug lead optimization. (Thesis). University of California – Irvine. Retrieved from http://www.escholarship.org/uc/item/6t03g54n

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Liu, Shuai. “Towards an automated computational pipeline to guide drug lead optimization.” 2015. Thesis, University of California – Irvine. Accessed March 02, 2021. http://www.escholarship.org/uc/item/6t03g54n.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Liu, Shuai. “Towards an automated computational pipeline to guide drug lead optimization.” 2015. Web. 02 Mar 2021.

Vancouver:

Liu S. Towards an automated computational pipeline to guide drug lead optimization. [Internet] [Thesis]. University of California – Irvine; 2015. [cited 2021 Mar 02]. Available from: http://www.escholarship.org/uc/item/6t03g54n.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Liu S. Towards an automated computational pipeline to guide drug lead optimization. [Thesis]. University of California – Irvine; 2015. Available from: http://www.escholarship.org/uc/item/6t03g54n

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Temple University

9. AKOCAK, SULEYMAN. Design and delivery of selective inhibitors of tumor overexpressed isozymes of carbonic anhydrase- towards new theranostic systems for cancer detection and treatment.

Degree: PhD, 2014, Temple University

URL: http://digital.library.temple.edu/u?/p245801coll10,282694

►

Pharmaceutical Sciences

Cancer is the second most common cause of death and a major cause of mortality in the world. The high mortality associated with… (more)

▼

Pharmaceutical Sciences

Cancer is the second most common cause of death and a major cause of mortality in the world. The high mortality associated with cancer is due to the fact that usually it is discovered too late, when it is metastasized to different organs and is very hard to cure. Finding more efficient, convenient and selective ways for early diagnosis and eradication of pre-malignant or malignant tumors of small dimensions is a task of utmost importance. The development of many malignant tumors was associated with hypoxia and the over-expression of specific membrane-bound carbonic anhydrase (CA) isozymes CA IX and CA XII. Malignant tissue of relatively small dimensions can grow fast and can invade the surrounding tissues by reverting to anaerobic metabolism and by acidifying the extracellular milieu around the tumor, increasing its invasiveness. Our goal is to detect and treat malignant hypoxic tumors using selective inhibitors of CA IX and CA XII and the objective of this thesis was to develop selective and efficient carbonic anhydrase inhibitors (CAIs) for the tumoral CA IX and CA XII that will leave unaltered the normal tissues. Two new sets of membrane-impermeant carbonic anhydrase inhibitors are proposed to be developed based on pyridinium positively-charged moieties attached to know CAI pharmacophores. Our guiding hypothesis was that modulation of carbonic anhydrase potency and tissue penetrability is possible to be achieved via fine tuning of pyridinium substitution. The use of appropriate substitutents on the pyridinium ring allowed the creation of CAI with special optical properties (e.g. fluorescence). The rationale for the research summarized in this thesis was that a CAI selective for membrane isozymes CA IX and CA XII over-expressed in cancer with controlled tissue penetrability can open new avenues in cancer early detection and treatment that will complement and/or potentiate present technologies and therapies.

Temple University – Theses

Advisors/Committee Members: Ilies, Marc A.;, Borenstein, Michael R., Canney, Daniel J., Mesaros, Eugen;.

Subjects/Keywords: Pharmaceutical sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

AKOCAK, S. (2014). Design and delivery of selective inhibitors of tumor overexpressed isozymes of carbonic anhydrase- towards new theranostic systems for cancer detection and treatment. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,282694

Chicago Manual of Style (16^th Edition):

AKOCAK, SULEYMAN. “Design and delivery of selective inhibitors of tumor overexpressed isozymes of carbonic anhydrase- towards new theranostic systems for cancer detection and treatment.” 2014. Doctoral Dissertation, Temple University. Accessed March 02, 2021. http://digital.library.temple.edu/u?/p245801coll10,282694.

MLA Handbook (7^th Edition):

AKOCAK, SULEYMAN. “Design and delivery of selective inhibitors of tumor overexpressed isozymes of carbonic anhydrase- towards new theranostic systems for cancer detection and treatment.” 2014. Web. 02 Mar 2021.

Vancouver:

AKOCAK S. Design and delivery of selective inhibitors of tumor overexpressed isozymes of carbonic anhydrase- towards new theranostic systems for cancer detection and treatment. [Internet] [Doctoral dissertation]. Temple University; 2014. [cited 2021 Mar 02]. Available from: http://digital.library.temple.edu/u?/p245801coll10,282694.

Council of Science Editors:

AKOCAK S. Design and delivery of selective inhibitors of tumor overexpressed isozymes of carbonic anhydrase- towards new theranostic systems for cancer detection and treatment. [Doctoral Dissertation]. Temple University; 2014. Available from: http://digital.library.temple.edu/u?/p245801coll10,282694

Temple University

10. Fan, Rong. DESIGN, SYNTHESIS, AND EVALUATION OF 5-LIPOXYGENASE INHIBITOR PRODRUGS FOR ALZHEIMER’S DISEASE.

Degree: PhD, 2016, Temple University

URL: http://digital.library.temple.edu/u?/p245801coll10,408778

►

Pharmaceutical Sciences

Pharmacologic blockade of 5-Lipoxygenase (5-LO) through its inhibitor, zileuton (Zyflo®), has been shown to reduce both gamma secretase-catalyzed misprocessing of amyloid precursor protein… (more)

▼

Pharmaceutical Sciences

Pharmacologic blockade of 5-Lipoxygenase (5-LO) through its inhibitor, zileuton (Zyflo®), has been shown to reduce both gamma secretase-catalyzed misprocessing of amyloid precursor protein and over-phosphorylation of tau protein (two hallmarks of Alzheimer’s disease (AD)) in transgenic mice (3xTg, Tg2576). However, zileuton suffers from low potency, liver toxicity, gastrointestinal side effects, and a suboptimal metabolism profile that hamper its development as a viable disease-modifying treatment for AD patients, who are usually older. Prodrugs of zileuton that deliver therapeutic concentrations of the parent molecule to the brain at low plasma concentrations could overcome these problems. In addition, other 5-LO inhibitors (ABT-761, BWA4C) with similar structure but greater potency might also be amenable to facilitate the discovery of the best prodrug for AD. A prodrug is a biologically inactive compound that is metabolized in the target tissue to release the parent drug. Prodrug strategies for Central Nervous System (CNS) delivery include masking polar groups with lipophilic moieties that promote brain penetration, Chemical Delivery Systems (CDS) that trap prodrugs in the brain and incorporating brain nutrients which engage Blood Brain Barrier (BBB) nutrient transporters. We have pursued all three strategies to enhance CNS delivery of the prototype hydroxyurea 5-LO inhibitor analog zileuton. To accomplish this task we synthesized and characterized 48 5-LO prodrugs for zileuton that falls into all three prodrug categories, and several lipophilic and CDS prodrugs for the other two 5-LO inhibitors (22 for ABT-761 and 22 for BWA4C,). The prodrugs were tested in a battery of in vitro assays that included solubility, plasma/simulated gastrointestinal fluid/microsomal stability, cell toxicity, and 5-LO inhibition assays. The promising compounds then went to the second tier of screening by equilibrium dialysis with plasma/brain homogenate/microsomes, and in vivo pilot pharmacokinetics study and full pharmacokinetics studies. As a consequence of this work, we identified six zileuton prodrugs (RF14, RF15, RF75, RF77, RF87, and RF88) with reasonable solubility, stability, safety, protein/lipid binding, and no 5-LO inhibitory activities and advanced them to the in vivo pilot pharmacokinetics studies. The most lipophilic prodrug RF58 was also tested in vivo as a comparator to RF14 and RF15 despite its fast metabolism in plasma. However, none of them demonstrated better CNS delivery of parent drug compared to administration of the parent itself. For the lipophilic prodrugs, two carbamate prodrugs (the racemic mixture of RF14 and RF15, RF58) were tested in the in vivo pilot study. The racemic mixture of RF14 and RF15 (RF14/15) with slightly increased lipophilicity (CLogP = 2.81 compared to 2.48 of zileuton) didn’t demonstrate a better brain penetration (Brain/Plasma = 0.06 in RF14/RF15 compared to 0.5 for zileuton). In addition, the carbamate linker was relatively stable in the brain, which resulted in…

Advisors/Committee Members: Childers, Wayne;, Canney, Daniel J., Abou-Gharbia, Magid, Korzekwa, Kenneth, Harrison, Boyd L.;.

Subjects/Keywords: Pharmaceutical sciences

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❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fan, R. (2016). DESIGN, SYNTHESIS, AND EVALUATION OF 5-LIPOXYGENASE INHIBITOR PRODRUGS FOR ALZHEIMER’S DISEASE. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,408778

Chicago Manual of Style (16^th Edition):

Fan, Rong. “DESIGN, SYNTHESIS, AND EVALUATION OF 5-LIPOXYGENASE INHIBITOR PRODRUGS FOR ALZHEIMER’S DISEASE.” 2016. Doctoral Dissertation, Temple University. Accessed March 02, 2021. http://digital.library.temple.edu/u?/p245801coll10,408778.

MLA Handbook (7^th Edition):

Fan, Rong. “DESIGN, SYNTHESIS, AND EVALUATION OF 5-LIPOXYGENASE INHIBITOR PRODRUGS FOR ALZHEIMER’S DISEASE.” 2016. Web. 02 Mar 2021.

Vancouver:

Fan R. DESIGN, SYNTHESIS, AND EVALUATION OF 5-LIPOXYGENASE INHIBITOR PRODRUGS FOR ALZHEIMER’S DISEASE. [Internet] [Doctoral dissertation]. Temple University; 2016. [cited 2021 Mar 02]. Available from: http://digital.library.temple.edu/u?/p245801coll10,408778.

Council of Science Editors:

Fan R. DESIGN, SYNTHESIS, AND EVALUATION OF 5-LIPOXYGENASE INHIBITOR PRODRUGS FOR ALZHEIMER’S DISEASE. [Doctoral Dissertation]. Temple University; 2016. Available from: http://digital.library.temple.edu/u?/p245801coll10,408778

Temple University

11. Kulkarni, Priyanka Rajendra. INTRACELLULAR UNBOUND CONCENTRATIONS OF ATORVASTATIN AND BOSENTAN: PREDICTION USING MODELING AND SIMULATION, AND EFFECT OF METABOLISM AND TRANSPORT.

Degree: PhD, 2017, Temple University

URL: http://digital.library.temple.edu/u?/p245801coll10,435930

►

Pharmaceutical Sciences

Accurate prediction of target activity of a drug and rational design of dosing regimen requires knowledge of concentration-time course of the drug at… (more)

▼

Pharmaceutical Sciences

Accurate prediction of target activity of a drug and rational design of dosing regimen requires knowledge of concentration-time course of the drug at the target. In vitro in vivo correlation (IVIVC) successfully predicts activity and pharmacokinetics of some drugs but is unsuccessful with many others due to poor permeability, transporter activity and use of plasma drug concentrations for determination of PK parameters. According to the free drug hypothesis, at steady state, the unbound drug concentration on either side of a biomembrane is equal. In this case, unbound plasma drug concentration acts as a good surrogate for unbound cell concentrations. However, presence of transporters coupled with poor membrane permeability result in violation of the free drug hypothesis. This results in failure of IVIVC and subsequent discrepancies in the prediction of target activity of pharmacokinetic predictions. Since it is the unbound drug that is capable of exerting the pharmacodynamic effect and available for intracellular metabolizing and transport machinery, knowledge of the unbound concentration inside the cell is very important. Experimental measurement of intracellular unbound concentration is very difficult due to the small size of the cell and complex cellular disposition resulting from activity of metabolizing enzymes, transporters, target binding and organelle binding within the cell. The present study, therefore, aims at predicting the intracellular unbound concentrations using modeling and simulation approach. Liver perfusion experiments were conducted in male Sprague Dawley rats with uptake transporter substrates atorvastatin and bosentan, in presence and absence of inhibitors of active uptake and metabolism, to study tissue distribution of these drugs in presence of uptake transport and metabolism. The outflow perfusate data thus obtained were used as input for the explicit membrane model for liver to predict the unbound intracellular concentrations of atorvastatin and bosentan. Similarly, in vivo pharmacokinetic experiments were also conducted in rats in presence and absence of inhibitors of active uptake and metabolism. The data obtained were used as input for hybrid compartmental models to predict unbound concentrations of these drugs upon intravenous dosing. Modeling exercises were also conducted to study the differential impact of inhibition of active uptake on plasma versus unbound cell concentrations. The effect of uptake transport on the induction potential of bosentan was studied in sandwich cultured rat hepatocytes and in in vivo studies in rats. Inhibition of active uptake in the liver perfusion studies increased the outflow perfusate concentrations, decreased the amount recovered in the bile for atorvastatin and bosentan, and decreased the liver concentrations for atorvastatin. The liver concentrations for bosentan with inhibition of active uptake were not different than the control group. Inhibition of active uptake in the in vivo studies also decreased the systemic clearance…

Advisors/Committee Members: Nagar, Swati V.;, Korzekwa, Kenneth, Wong, Ho-Lun, Tweedie, Donald;.

Subjects/Keywords: Pharmaceutical sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kulkarni, P. R. (2017). INTRACELLULAR UNBOUND CONCENTRATIONS OF ATORVASTATIN AND BOSENTAN: PREDICTION USING MODELING AND SIMULATION, AND EFFECT OF METABOLISM AND TRANSPORT. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,435930

Chicago Manual of Style (16^th Edition):

Kulkarni, Priyanka Rajendra. “INTRACELLULAR UNBOUND CONCENTRATIONS OF ATORVASTATIN AND BOSENTAN: PREDICTION USING MODELING AND SIMULATION, AND EFFECT OF METABOLISM AND TRANSPORT.” 2017. Doctoral Dissertation, Temple University. Accessed March 02, 2021. http://digital.library.temple.edu/u?/p245801coll10,435930.

MLA Handbook (7^th Edition):

Kulkarni, Priyanka Rajendra. “INTRACELLULAR UNBOUND CONCENTRATIONS OF ATORVASTATIN AND BOSENTAN: PREDICTION USING MODELING AND SIMULATION, AND EFFECT OF METABOLISM AND TRANSPORT.” 2017. Web. 02 Mar 2021.

Vancouver:

Kulkarni PR. INTRACELLULAR UNBOUND CONCENTRATIONS OF ATORVASTATIN AND BOSENTAN: PREDICTION USING MODELING AND SIMULATION, AND EFFECT OF METABOLISM AND TRANSPORT. [Internet] [Doctoral dissertation]. Temple University; 2017. [cited 2021 Mar 02]. Available from: http://digital.library.temple.edu/u?/p245801coll10,435930.

Council of Science Editors:

Kulkarni PR. INTRACELLULAR UNBOUND CONCENTRATIONS OF ATORVASTATIN AND BOSENTAN: PREDICTION USING MODELING AND SIMULATION, AND EFFECT OF METABOLISM AND TRANSPORT. [Doctoral Dissertation]. Temple University; 2017. Available from: http://digital.library.temple.edu/u?/p245801coll10,435930

12. P. SHASHIDHAR. DESIGN AND EVALUATION OF ORAL ANTIDIABETIC AGENTS AS BILAYERED TABLETS;.

Degree: 2013, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/10196

►

The present work, an industrial project, entitled Formulation Development and Evaluation of metformin hydrochloride sustained release and glimepiride immediate release bilayered Tablet, taken up in… (more)

Subjects/Keywords: PHARMACEUTICAL SCIENCES

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APA (6^th Edition):

SHASHIDHAR, P. (2013). DESIGN AND EVALUATION OF ORAL ANTIDIABETIC AGENTS AS BILAYERED TABLETS;. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/10196

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

SHASHIDHAR, P.. “DESIGN AND EVALUATION OF ORAL ANTIDIABETIC AGENTS AS BILAYERED TABLETS;.” 2013. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed March 02, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/10196.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

SHASHIDHAR, P.. “DESIGN AND EVALUATION OF ORAL ANTIDIABETIC AGENTS AS BILAYERED TABLETS;.” 2013. Web. 02 Mar 2021.

Vancouver:

SHASHIDHAR P. DESIGN AND EVALUATION OF ORAL ANTIDIABETIC AGENTS AS BILAYERED TABLETS;. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2013. [cited 2021 Mar 02]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/10196.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

SHASHIDHAR P. DESIGN AND EVALUATION OF ORAL ANTIDIABETIC AGENTS AS BILAYERED TABLETS;. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2013. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/10196

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. Vasantharaju S G. Development of Thiazolidin 4 one Derivatives for possible Hypolipidaemic and Antidiabetic activities.

Degree: Pharmaceutical Sciences, 2011, Manipal University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/4970

►

Twenty one thiazolidin-4-one derivatives were synthesized, purified by chromatographic and non-chromatographic methods. These were characterized through physical constants like melting point, various spectral and chromatographic… (more)

Subjects/Keywords: Pharmaceutical Sciences

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APA (6^th Edition):

G, V. S. (2011). Development of Thiazolidin 4 one Derivatives for possible Hypolipidaemic and Antidiabetic activities. (Thesis). Manipal University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/4970

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

G, Vasantharaju S. “Development of Thiazolidin 4 one Derivatives for possible Hypolipidaemic and Antidiabetic activities.” 2011. Thesis, Manipal University. Accessed March 02, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/4970.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

G, Vasantharaju S. “Development of Thiazolidin 4 one Derivatives for possible Hypolipidaemic and Antidiabetic activities.” 2011. Web. 02 Mar 2021.

Vancouver:

G VS. Development of Thiazolidin 4 one Derivatives for possible Hypolipidaemic and Antidiabetic activities. [Internet] [Thesis]. Manipal University; 2011. [cited 2021 Mar 02]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/4970.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

G VS. Development of Thiazolidin 4 one Derivatives for possible Hypolipidaemic and Antidiabetic activities. [Thesis]. Manipal University; 2011. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/4970

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. Shanmugam, Ramesh Kumar. Lyophilized formulation development with novel excipients derived from cassia roxburghii for a pegylated therapeutic protein.

Degree: Pharmaceutical Sciences, 2013, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/13225

►

The principal of this thesis is newlineThe objective of the present research is to assess the use of a constituent of Cassia Roxburghii as a… (more)

Subjects/Keywords: Pharmaceutical Sciences

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APA (6^th Edition):

Shanmugam, R. K. (2013). Lyophilized formulation development with novel excipients derived from cassia roxburghii for a pegylated therapeutic protein. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/13225

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shanmugam, Ramesh Kumar. “Lyophilized formulation development with novel excipients derived from cassia roxburghii for a pegylated therapeutic protein.” 2013. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed March 02, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/13225.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shanmugam, Ramesh Kumar. “Lyophilized formulation development with novel excipients derived from cassia roxburghii for a pegylated therapeutic protein.” 2013. Web. 02 Mar 2021.

Vancouver:

Shanmugam RK. Lyophilized formulation development with novel excipients derived from cassia roxburghii for a pegylated therapeutic protein. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2013. [cited 2021 Mar 02]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/13225.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shanmugam RK. Lyophilized formulation development with novel excipients derived from cassia roxburghii for a pegylated therapeutic protein. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2013. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/13225

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Vijapur, Laxman. Thiolated chitosans as potential carriers for selected api s targeted to git for enhanced mucoadhesion.

Degree: Pharmaceutical Sciences, 2013, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/13228

►

The phenomenon of mucoadhesion, however, is unpredictable due to varying turnover time and composition of mucus, different behavior of mucoadhesive devices over the pH range,… (more)

▼

The phenomenon of mucoadhesion, however, is unpredictable due to varying turnover time and composition of mucus, different behavior of mucoadhesive devices over the pH range, and disease conditions. The lack of specificity in adhering to specific mucous tissue seriously limits drug delivery/targeting through this technique, thus mucoadhesive polymers in many cases are not proven to be effective as pharmaceutical glue. Chitosan is a natural polycationic copolymer consisting of glucosamine and N-acetylglucosamine units. The polymer has valuable properties as a biomaterial because it is considered to be mucoadhesive, biocompatible, biodegradable and non-toxic. The objective of present study is to enhance the mucoadhesion of chitosan by thiolating chitosan with various thiolating agents which are capable of forming covalent disulfide bonds between thiomers and cysteine-rich subdomains of mucus glycoproteins and enhance mucoadhesion of tablet. The derivatizations of the primary amino groups of chitosan with thiolating agents like Thioglycolic acid and L-Cysteine leads to the formation of thiolated chitosan where the reaction was mediated by EDAC. To evaluate the mucoadhesive property of thiolated chitosan, methotrexate and cefuroxime axetil was chosen as model drug. Mucoadhesive tablets of thiolated chitosan were prepared by direct compression method and prepared formulations were subjected to evaluations like in vitro adhesion, water uptake studies, in vitro drug release studies and in vivo residence studies. In vitro dissolution studies of thiolated chitosan tablet indicated non-Fickian diffusion controlled drug release mechanism and was best fitted into Korsmeyer Peppas equation. In vitro mucoadhesion was up to 48.13 ± 0.31 hours for MTXF6 formulation and 48.38 ± 0.04 for CF6 where as In vivo radiographic studies conducted in rabbits for optimized formulation indicated over 36 hours retention of tablet in the stomach region for MTXF6 formulation. Hence from the above result we found that thiolated chitosan has enhanced mucoadhes

References

Advisors/Committee Members: Sreenivas S A.

Subjects/Keywords: Pharmaceutical Sciences

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❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vijapur, L. (2013). Thiolated chitosans as potential carriers for selected api s targeted to git for enhanced mucoadhesion. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/13228

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vijapur, Laxman. “Thiolated chitosans as potential carriers for selected api s targeted to git for enhanced mucoadhesion.” 2013. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed March 02, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/13228.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vijapur, Laxman. “Thiolated chitosans as potential carriers for selected api s targeted to git for enhanced mucoadhesion.” 2013. Web. 02 Mar 2021.

Vancouver:

Vijapur L. Thiolated chitosans as potential carriers for selected api s targeted to git for enhanced mucoadhesion. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2013. [cited 2021 Mar 02]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/13228.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vijapur L. Thiolated chitosans as potential carriers for selected api s targeted to git for enhanced mucoadhesion. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2013. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/13228

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

16. Shinde, Prashant Vishwas. Formulation and development of Pulsatile drug delivery systems PDDS.

Degree: Pharmaceutical sciences, 2013, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/13229

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The principal of this thesis is newlineNow a day there is increase interest in academics as well as industrial research groups in novel dosage forms… (more)

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The principal of this thesis is newlineNow a day there is increase interest in academics as well as industrial research groups in novel dosage forms that can be retained in the stomach for a prolonged and predictable period of time. newlinePulsatile drug delivery systems are gaining a lot of interest now days. These systems are designed according to the circadian rhythm of the body. These systems deliver the drug at specific time as per the pathophysiological need of the disease, resulting in improved patient compliance and therapeutic efficacy. Which is meant as the liberation of drugs following programmed lag phases, has drawn increasing interest, especially in view of emerging chronotherapeutic approaches. Pulsatile drug delivery shows rhythms like rheumatoid arthritis, cardiovascular diseases, asthma, peptic ulcer, allergic rhinitis. newlineAceclofenac, a nonsteroidal anti-inflammatory drug, is used for the symptomatic relief of pain and joint stiffness in patients suffering from rheumatoid arthritis, which is characterized by diurnal variation in circulating levels of proinflammatory cytokines, interleukin-6 and/or tumor necrosis factor-and#945;. Due to this diurnal variation, many symptoms and signs of active rheumatoid arthritis are manifested in the morning.7 on oral administration at bed-time, releases Aceclofenac after a desired lag time of about 360 - 420 minutes which corresponds with peak levels of proinflammatory mediators. newlineThe objective of this work was to develop current study illustrates the formulation, characterization, and optimization of press coated tablet,. floating-pulsatile drug delivery system and Formulation development of coated tablet of Aceclofenac by using coating of rupturable layer. Press-coating, also known as compression coating, is relatively simple and cheap, and may involve direct compression of both the core and the coat, obviating the need for a separate coating process and the use of coating solutions. Materials such as hydrophilic cellulose derivatives can be used newline newline

References

Advisors/Committee Members: Mayee, Rahul V.

Subjects/Keywords: Pharmaceutical sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shinde, P. V. (2013). Formulation and development of Pulsatile drug delivery systems PDDS. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/13229

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shinde, Prashant Vishwas. “Formulation and development of Pulsatile drug delivery systems PDDS.” 2013. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed March 02, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/13229.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shinde, Prashant Vishwas. “Formulation and development of Pulsatile drug delivery systems PDDS.” 2013. Web. 02 Mar 2021.

Vancouver:

Shinde PV. Formulation and development of Pulsatile drug delivery systems PDDS. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2013. [cited 2021 Mar 02]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/13229.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shinde PV. Formulation and development of Pulsatile drug delivery systems PDDS. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2013. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/13229

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

17. Desai Sanjeevani Rajaram. Development of Surfactant Based Novel Topical Formulation for Antifungal Therapy;.

Degree: 2014, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/15202

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Skin is an extensively act as route of administration for local and systemic API application and is potentially a route for their delivery as non… (more)

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Skin is an extensively act as route of administration for local and systemic API application and is potentially a route for their delivery as non ionic surfactant vesicle. Drug delivery by topical route is effective only by better skin penetration to the required layer of skin. Dermatophyte causes the fungal infection, in which dermatophyte infect top layer of skin. Patient suffering from cutaneous candidiasis cure with combined formulation of nystatin and triamcinolone acetonie reveal prominent healing of erythema and pruritis than therapy of nystatin and triamcinolone acetonide alone. newlineTopical conventional formulations have limitation like penetration through barrier layer of skin. Barrier layer hampers deposition of active pharmaceutical ingredient. Therefore it is essential to select proper carrier by taking in to consideration that selected carrier enhance deposition of API (active pharmaceutical ingredient) by means of topical medicament. Topical applicability of niosomes was further enhanced by developing niosomal gel formulation using carbomers. In our present research work, we have incorporated drug into niosome by using Ether injection method by applying 32 factorial designs. The niosomes were characterized for poly-dispersibility index, entrapment power, vesicle charge determination, API release study. Niosomal dispersion showed sustained released but further topical applicability of the developed formulation was enhanced by development of gel formulation. Stable niosomal gel was evaluated for the various parameters like drug content, pH, spredability, viscosity, microscopic evaluation. The stability, Safety and efficacy studies of the developed gel were carried out.Extensive research study showed that the developed niogel formulation has shown great potential in the topical antifungal therapy by giving a extended release profile. Therefore safe, efficacious, non irritant surfactant based topical formulation was successfully developed for treatment of fungal disease. newline newline

Advisors/Committee Members: Disouza John Intru.

Subjects/Keywords: Pharmaceutical Sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rajaram, D. S. (2014). Development of Surfactant Based Novel Topical Formulation for Antifungal Therapy;. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/15202

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rajaram, Desai Sanjeevani. “Development of Surfactant Based Novel Topical Formulation for Antifungal Therapy;.” 2014. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed March 02, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/15202.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rajaram, Desai Sanjeevani. “Development of Surfactant Based Novel Topical Formulation for Antifungal Therapy;.” 2014. Web. 02 Mar 2021.

Vancouver:

Rajaram DS. Development of Surfactant Based Novel Topical Formulation for Antifungal Therapy;. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. [cited 2021 Mar 02]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15202.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rajaram DS. Development of Surfactant Based Novel Topical Formulation for Antifungal Therapy;. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15202

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

18. Chinmay Anand. Novel strategies in formulation development And evaluation of dispersible tablets;.

Degree: 2014, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/15220

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The basic aim behind development of any drug delivery system (DDS) is to achieve a safe and effective therapy for the human being. The dispersible… (more)

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The basic aim behind development of any drug delivery system (DDS) is to achieve a safe and effective therapy for the human being. The dispersible tablet provides a utility dosage form, reducing the need for multiple formulations of the same drug. The novel concept of Rapid dispersible drug delivery system emerged from the desire to provide patient with conventional mean of taking their medication. In recent days major concentration for development work is laid down on the development of organoleptically elegant such as good in taste and patient friendly drug delivery system for the usage of pediatric and geriatric patients. The greater bioavailability of a drug from Rapid dispersible and or dissolving formulations also make it preferable dose as compare to conventional oral dosage forms. newline newlineThe main aim of this study is to develop new concept for the formulation of rapid dispersible tablets or Fast dissolving tablets using novel concepts such as solubility enhancement of active for fast and better release of drug to achieve better bioavailability of active in vivo, taste masking of active with various techniques to improve organoleptic properties and patience compliance. The design of formulation was basically developed for the pediatric and geriatric patients. Paracetamol and Tolfenamic Acid were used as model drugs in formulation study. The present study is an attempt towards application of some novel concepts in formulation of Rapid Dispersible Tablets. On the basis of preformulation study and characterization of active, development of rapid dispersible tablets of Tolfenamic acid initiated with concept of co-micronization with diluents requires. The rapid release of formulation was the basic behind the experimental study. Optimization of formulation parameters was completed to achieve the balance between various physical properties such as disintegration and dispersion time and analytical properties such as release profile of tablets. newline newline

Advisors/Committee Members: G. Vidyasagar.

Subjects/Keywords: Pharmaceutical Sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Anand, C. (2014). Novel strategies in formulation development And evaluation of dispersible tablets;. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/15220

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Anand, Chinmay. “Novel strategies in formulation development And evaluation of dispersible tablets;.” 2014. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed March 02, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/15220.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Anand, Chinmay. “Novel strategies in formulation development And evaluation of dispersible tablets;.” 2014. Web. 02 Mar 2021.

Vancouver:

Anand C. Novel strategies in formulation development And evaluation of dispersible tablets;. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. [cited 2021 Mar 02]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15220.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Anand C. Novel strategies in formulation development And evaluation of dispersible tablets;. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15220

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Bhagwat Durgacharan Arun. Self microemulsifying drug delivery system of cardiovascular drugs for enhanced bioavailability;.

Degree: 2014, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/15221

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Aim of present investigation was to develop Solid self micro emulsifying drug delivery system (S-SMEDDS) of cardiovascular drugs such as Telmisartan (TEL) and Verapamil Hydrochloride… (more)

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Aim of present investigation was to develop Solid self micro emulsifying drug delivery system (S-SMEDDS) of cardiovascular drugs such as Telmisartan (TEL) and Verapamil Hydrochloride (VPH) to enhance solubility, dissolution rate which may improve therapeutic performance and drug loading capacity so as to develop alternative to traditional oral formulations to improve bioavailability. In this study Oleic acid, Tween 80 and PEG 400 were selected as oil, surfactant and co-surfactant respectively for TEL and Castor oil, Labrasol, Transcutol P were selected as oil, surfactant and co-surfactant respectively for VPH. The three formulations were selected from ternary phase diagram at Km value 3, named as TLM1, TLM2, and TLM3 for TEL and VLM1, VLM2 and VLM3 for VPH and prepared successfully. Prepared liquid SMEDDS were evaluated for different parameters. From this study it was found that all formulations of liquid SMEDDS showed globule size in nanometric range, good stability with no phase separation, creaming or cracking and rapidly formed micro emulsion which was clear and slightly bluish in appearance. All these formulations were converted into S-SMEDDS by spray drying and adsorption technique. For spray drying maltodextrin and HPMC K15M were used as solid carrier for TEL and VPH respectively and for adsorption technique Neusilin US2 and Aerosil 200 were used as solid carrier for TEL. Prepared S-SMEDDS were evaluated for micromeritic properties, various reconstitution properties and for in-vitro dissolution study. Formulations were optimized on the basis of drug content, in-vitro drug release, globule size, PDI, zeta potential of reconstituted S-SMEDDS, spray dried process yield, etc and selected formulations were further studied for solid state characterization, morphological analysis, ex-vivo intestinal permeability studies, bioavailability and stability study. Ex-vivo intestinal permeability study of TEL S-SMEDDS formulations concluded that, drug diffused through the biological membrane has more when it is given in

Advisors/Committee Members: Disouza John Intru.

Subjects/Keywords: Pharmaceutical Sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Arun, B. D. (2014). Self microemulsifying drug delivery system of cardiovascular drugs for enhanced bioavailability;. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/15221

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Arun, Bhagwat Durgacharan. “Self microemulsifying drug delivery system of cardiovascular drugs for enhanced bioavailability;.” 2014. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed March 02, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/15221.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Arun, Bhagwat Durgacharan. “Self microemulsifying drug delivery system of cardiovascular drugs for enhanced bioavailability;.” 2014. Web. 02 Mar 2021.

Vancouver:

Arun BD. Self microemulsifying drug delivery system of cardiovascular drugs for enhanced bioavailability;. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. [cited 2021 Mar 02]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15221.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arun BD. Self microemulsifying drug delivery system of cardiovascular drugs for enhanced bioavailability;. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15221

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. Rathi Sanjeshkumar Gotam. Extraction and evaluation of naturetic plants for anti fungal and anti bacterial activities;.

Degree: 2014, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/15222

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The world society depends on natural product on the bases of various reports. Thus Aim to investigate on six different natural product on four different… (more)

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The world society depends on natural product on the bases of various reports. Thus Aim to investigate on six different natural product on four different solvents for extraction Methanol, Water, Chloroform, n-Hexane were extracted through Soxhlet apparatus tested at various concentrations (100mg/ml, 50mg/ml, and 25mg/ml) against three bacterial strains such as Bacillus subtilis (121), Esc. coli (118), Staphylococcus epidermidis (3615) also tested against three fungal strains such as Candida glabreta (1632), Asper. flavus (871), and Candida albicans (183) used for antifungal and anti bacterial method for ZI and MIC against various microorganisms. A total 4 extract belonging to 6 plants were investigated. Among the plants tested, H. rosa sinensis, V. negundo L, S. lappa Costus showed best antibacterial and antifungal activity on methanol extracts according to Zone of inhbition. Thus according to the result compared with the standard drug it was discussed that the extracted on Methanol, Chloroform, n-Hexane and Water. The Methanol showed the good Zone of inhibition (mm) for the treatment at various bacterial and fungal diseases. It means that the methanol extract showed the highest percentage yield must be near to the potency to the standard drug range If Zee Zee 23mm-26mm and 17mm-20mm with a fungal strain of bacterial test organisms gainst.The screening for extraction and evaluation of naturetic plants for anti-fungal and anti-bacterial activities for Minimum inhibitory concentration (µg/ml). Among the six plants used four different solvents at antimicrobial strains for antibacterial and antifungal activity it showed the best on S. emarginatus, S. lappa Costus, on n-hexane extract according to Minimum inhibitory concentration leaf it showed satisfactory result against various bacteria and fungi on n-hexane extract showed the highest Minimum inhibitory concentration (µg/ml) 15-18 (and#956;g/ml) while minimum inhibitory concentration showed the lowest report then other remained crude extract Minimum Inhibitory concentrat

Advisors/Committee Members: Patel Kanubhai Rameshbhai.

Subjects/Keywords: Pharmaceutical Sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gotam, R. S. (2014). Extraction and evaluation of naturetic plants for anti fungal and anti bacterial activities;. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/15222

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gotam, Rathi Sanjeshkumar. “Extraction and evaluation of naturetic plants for anti fungal and anti bacterial activities;.” 2014. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed March 02, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/15222.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gotam, Rathi Sanjeshkumar. “Extraction and evaluation of naturetic plants for anti fungal and anti bacterial activities;.” 2014. Web. 02 Mar 2021.

Vancouver:

Gotam RS. Extraction and evaluation of naturetic plants for anti fungal and anti bacterial activities;. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. [cited 2021 Mar 02]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15222.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gotam RS. Extraction and evaluation of naturetic plants for anti fungal and anti bacterial activities;. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15222

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. Ravikumar. Studies on borassus flabellifer fruit mucilage as versatile excipient for pharmaceutical formulations;.

Degree: 2014, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/15528

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There are number of synthetic polymers are available in market for pharmaceutical formulations, but these synthetic polymers have certain disadvantages such as high cost, toxicity,… (more)

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There are number of synthetic polymers are available in market for pharmaceutical formulations, but these synthetic polymers have certain disadvantages such as high cost, toxicity, environmental pollution during synthesis,non-renewable sources,side effects, and poor patient compliance.Because of these disadvantages natural polymers such as natural gums and mucilage are preferred to semi synthetic and synthetic excipients because of the following advantages low cost and natural origin, free from side effects, biocompatible and bio-acceptable, renewable source, environmental friendly processing, local availability etc. Because of this demand for these substances are increasing and new sources are being developed. newlineThe endopserm of Borassus flabellifer fruit contains a high proportion of mucilage. Literature survey revealed that comprehensive physicochemical characterization and exploration of Borassus flabellifer fruit mucilage (BFM) as versatile pharmaceutical excipients in pharmaceutical formulations had not been done. Hence, the present study was aimed to enhance the use of BFM as a natural plant based excipients to develop various pharmaceutical formulations and it will encourage cultivation and use of this mucilage in the pharmaceutical industry. newlineThe disintegrating property of the BFM had been studied in comparison with commercially available superdisintegrant viz croscarmellose sodium in the formulation of Metformin HCl FDT s. The results indicated that the BFM exhibited better disintegrating property at lower concentration viz; 1%w/w than the crosscarmellose sodium, and hence it can be used as a superdisintegrant in the tablet formulations.The extracted BFM powder was evaluated for its binding properties in paracetamol compressed tablet. Its binding efficiency was compared with starch paste, which was used as standard binder at 10% w/v concentration. It can be observed from the results that tablets prepared using BFM at 8%w/v are comparable with tablets prepared using 10% w/v starch paste as standard binder.

Advisors/Committee Members: Rajarajeshwari N.

Subjects/Keywords: Pharmaceutical sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ravikumar. (2014). Studies on borassus flabellifer fruit mucilage as versatile excipient for pharmaceutical formulations;. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/15528

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ravikumar. “Studies on borassus flabellifer fruit mucilage as versatile excipient for pharmaceutical formulations;.” 2014. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed March 02, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/15528.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ravikumar. “Studies on borassus flabellifer fruit mucilage as versatile excipient for pharmaceutical formulations;.” 2014. Web. 02 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

Ravikumar. Studies on borassus flabellifer fruit mucilage as versatile excipient for pharmaceutical formulations;. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. [cited 2021 Mar 02]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15528.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ravikumar. Studies on borassus flabellifer fruit mucilage as versatile excipient for pharmaceutical formulations;. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15528

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

22. Shaik.Md.Zakir Hussain. Novel functionalised polymer for nanoparticle formulaton with anti cancer drug;.

Degree: 2014, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/15530

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The aim of this study was to investigate whether various polymers and drugs interacts in a specific manner and whether the nature of these interactions… (more)

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The aim of this study was to investigate whether various polymers and drugs interacts in a specific manner and whether the nature of these interactions I influences the physicochemical characteristic of the particles and their drug loading and release profile. By investigating drugs belonging to various classes and with different properties it has been possible to correlate properties associated with drug and pendent functional group of the polymer which are ultimately responsible for the drug loading and release characteristic. The chemistry and structure of poly (glycerol adipate) facilitate its substitution with various pendent functional groups leading to modification of the physicochemical properties of the polymer. Modified backbone then can be selected based upon the properties of the compound to be incorporated. Thus, this could be explored as a drug delivery system without many of the limitations of commercially available polymer. For some drug polymer formulations, good loading and controlled release rates have been achieved. Compared to various conventional polymer systems reported for nanoparticle formulations, poly (glycerol adipate) polymer have also demonstrated the ability to control rate of release of highly water soluble drugs, even from the most hydrophilic polymer backbone in its unsubustituted form. From the various drug loading and release profile it has been demonstrated that, unlike reported literature, particle size is not the primary factor influencing drug release over the relatively small range of particle size seen in this study. Neither is the water solubility of either the drug or the polymer alone responsible for the rapid and uncontrolled release profile from nanoparticles. Thus, Drug polymer interactions are more likely to influence drug loading and release and unlikely common reports in the literature, hydrophilicity, molecular weight or concentration of polymer / drug are less likely to affect these parameters in isolation. Recently, biodegradable polyesters such as poly

Advisors/Committee Members: G.VIDYA SAGAR.

Subjects/Keywords: Pharmaceutical sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hussain, S. (2014). Novel functionalised polymer for nanoparticle formulaton with anti cancer drug;. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/15530

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hussain, Shaik.Md.Zakir. “Novel functionalised polymer for nanoparticle formulaton with anti cancer drug;.” 2014. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed March 02, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/15530.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hussain, Shaik.Md.Zakir. “Novel functionalised polymer for nanoparticle formulaton with anti cancer drug;.” 2014. Web. 02 Mar 2021.

Vancouver:

Hussain S. Novel functionalised polymer for nanoparticle formulaton with anti cancer drug;. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. [cited 2021 Mar 02]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15530.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hussain S. Novel functionalised polymer for nanoparticle formulaton with anti cancer drug;. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15530

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Chemansaheb Meerasaheb Jamkhandi. Synthesis and screening of newer benzotriazole derivatives for their antibacterial and antioxidant potential;.

Degree: 2014, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/16119

►

The objective of the present study was to evaluate antioxidant, antibacterial activity of a series of Benzotriazole Substituted with N-Phenylacetamide (Ia to Va), acetylcarbamic acid… (more)

Subjects/Keywords: Pharmaceutical Sciences

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APA (6^th Edition):

Jamkhandi, C. M. (2014). Synthesis and screening of newer benzotriazole derivatives for their antibacterial and antioxidant potential;. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/16119

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jamkhandi, Chemansaheb Meerasaheb. “Synthesis and screening of newer benzotriazole derivatives for their antibacterial and antioxidant potential;.” 2014. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed March 02, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/16119.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jamkhandi, Chemansaheb Meerasaheb. “Synthesis and screening of newer benzotriazole derivatives for their antibacterial and antioxidant potential;.” 2014. Web. 02 Mar 2021.

Vancouver:

Jamkhandi CM. Synthesis and screening of newer benzotriazole derivatives for their antibacterial and antioxidant potential;. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. [cited 2021 Mar 02]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/16119.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jamkhandi CM. Synthesis and screening of newer benzotriazole derivatives for their antibacterial and antioxidant potential;. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/16119

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

24. K.PAVAN KUMAR. ANTIDIABETIC AND ANTICONVULSANT ACTIVITY OF SOME MEDICINAL PLANTS;.

Degree: 2013, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/10292

►

The present study reveals antidiabetic activity of Madhuca indica and anticonvulsant activity of Vitex negundo. Screening of antidiabetic activity was carried against streptozotocin and streptozotocin-nicotinamide… (more)

Subjects/Keywords: PHARMACEUTICAL SCIENCES

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APA (6^th Edition):

KUMAR, K. (2013). ANTIDIABETIC AND ANTICONVULSANT ACTIVITY OF SOME MEDICINAL PLANTS;. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/10292

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

KUMAR, K.PAVAN. “ANTIDIABETIC AND ANTICONVULSANT ACTIVITY OF SOME MEDICINAL PLANTS;.” 2013. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed March 02, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/10292.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

KUMAR, K.PAVAN. “ANTIDIABETIC AND ANTICONVULSANT ACTIVITY OF SOME MEDICINAL PLANTS;.” 2013. Web. 02 Mar 2021.

Vancouver:

KUMAR K. ANTIDIABETIC AND ANTICONVULSANT ACTIVITY OF SOME MEDICINAL PLANTS;. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2013. [cited 2021 Mar 02]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/10292.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

KUMAR K. ANTIDIABETIC AND ANTICONVULSANT ACTIVITY OF SOME MEDICINAL PLANTS;. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2013. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/10292

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Temple University

25. Yadav, Jaydeep. EVALUATING PHARMACOKINETIC DRUG-DRUG INTERACTIONS DUE TO TIME DEPENDENT INHIBITION OF CYTOCHROME P450s.

Degree: PhD, 2018, Temple University

URL: http://digital.library.temple.edu/u?/p245801coll10,524248

►

Pharmaceutical Sciences

Time-dependent inactivation (TDI) of CYPs is a leading cause of clinical drug-drug interactions (DDIs). Current methods tend to over-predict DDIs. In this study,… (more)

▼

Pharmaceutical Sciences

Time-dependent inactivation (TDI) of CYPs is a leading cause of clinical drug-drug interactions (DDIs). Current methods tend to over-predict DDIs. In this study, a numerical approach was used to model complex CYP3A TDI in human liver microsomes. Inhibitors evaluated include troleandomycin (TAO), erythromycin (ERY), verapamil (VER), Paroxetine (PAR), itraconazole (ITZ) and diltiazem (DTZ) along with primary metabolites N-demethyl erythromycin (NDE), norverapamil (NV), and N-desmethyl diltiazem (MA). Complexities incorporated in the models included multiple binding kinetics, quasi-irreversible inactivation, sequential metabolism, inhibitor depletion, and membrane partitioning. The different factors affecting TDI kinetics were evaluated such as lipid partitioning, inhibitor depletion, presence of transporters. The inactivation parameters obtained from numerical method were incorporated into static in-vitro – in-vivo correlation (IVIVC) models to predict clinical DDIs. For 123 clinically observed DDIs, using a hepatic CYP3A synthesis rate constant of 0.000146 min-1, the average fold difference between observed and predicted DDIs was 2.97 for the standard replot method and 1.66 for the numerical method. Similar results were obtained using a synthesis rate constant of 0.00032 min-1. These results suggest that numerical methods can successfully model complex in-vitro TDI kinetics and that the resulting DDI predictions are more accurate than those obtained with the standard replot approach. Chapter one presents the detailed introduction along with the hypothesis and significance of the project. Chapter 2 includes the development of the bioanalytical method for quantitation of various compounds which includes inactivators and their primary metabolites. Chapter 3 entails the discussion on in-vivo studies in rats involving TDI mediated DDI studies. Chapter 4 discusses the in-vitro studies and use of the numerical method for evaluation of TDI kinetics. Chapter 5 and chapter 6 provides discussion on the impact of inhibitor depletion and partitioning of TDI kinetics and how these two could lead to misinterpretation of TDI results. Chapter 6 also provides a discussion on how transporters could affect TDI results mainly from hepatocyte studies. Chapter 7 involves prediction of TDI mediated DDI using static modeling. Chapter 8 is a case study on bosentan involving induction mediated DDI.

Temple University – Theses

Advisors/Committee Members: Nagar, Swati;, Korzekwa, Kenneth, Childers, Wayne, Polli, Joseph;.

Subjects/Keywords: Pharmaceutical sciences

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APA (6^th Edition):

Yadav, J. (2018). EVALUATING PHARMACOKINETIC DRUG-DRUG INTERACTIONS DUE TO TIME DEPENDENT INHIBITION OF CYTOCHROME P450s. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,524248

Chicago Manual of Style (16^th Edition):

Yadav, Jaydeep. “EVALUATING PHARMACOKINETIC DRUG-DRUG INTERACTIONS DUE TO TIME DEPENDENT INHIBITION OF CYTOCHROME P450s.” 2018. Doctoral Dissertation, Temple University. Accessed March 02, 2021. http://digital.library.temple.edu/u?/p245801coll10,524248.

MLA Handbook (7^th Edition):

Yadav, Jaydeep. “EVALUATING PHARMACOKINETIC DRUG-DRUG INTERACTIONS DUE TO TIME DEPENDENT INHIBITION OF CYTOCHROME P450s.” 2018. Web. 02 Mar 2021.

Vancouver:

Yadav J. EVALUATING PHARMACOKINETIC DRUG-DRUG INTERACTIONS DUE TO TIME DEPENDENT INHIBITION OF CYTOCHROME P450s. [Internet] [Doctoral dissertation]. Temple University; 2018. [cited 2021 Mar 02]. Available from: http://digital.library.temple.edu/u?/p245801coll10,524248.

Council of Science Editors:

Yadav J. EVALUATING PHARMACOKINETIC DRUG-DRUG INTERACTIONS DUE TO TIME DEPENDENT INHIBITION OF CYTOCHROME P450s. [Doctoral Dissertation]. Temple University; 2018. Available from: http://digital.library.temple.edu/u?/p245801coll10,524248

26. Fiandaca, Maggie. Ionic Liquid Formation and Characterization of a Non-steroid Anti-inflammatory Drug.

Degree: 2020, University of the Sciences in Philadelphia

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=22620871

► The present work focuses on modifying a non-steroid anti-inflammatory drug (NSAID) into an ionic liquid and evaluating the resulting thermal behavior and structural changes of… (more)

Subjects/Keywords: Pharmaceutical sciences

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APA (6^th Edition):

Fiandaca, M. (2020). Ionic Liquid Formation and Characterization of a Non-steroid Anti-inflammatory Drug. (Thesis). University of the Sciences in Philadelphia. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=22620871

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fiandaca, Maggie. “Ionic Liquid Formation and Characterization of a Non-steroid Anti-inflammatory Drug.” 2020. Thesis, University of the Sciences in Philadelphia. Accessed March 02, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=22620871.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fiandaca, Maggie. “Ionic Liquid Formation and Characterization of a Non-steroid Anti-inflammatory Drug.” 2020. Web. 02 Mar 2021.

Vancouver:

Fiandaca M. Ionic Liquid Formation and Characterization of a Non-steroid Anti-inflammatory Drug. [Internet] [Thesis]. University of the Sciences in Philadelphia; 2020. [cited 2021 Mar 02]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=22620871.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fiandaca M. Ionic Liquid Formation and Characterization of a Non-steroid Anti-inflammatory Drug. [Thesis]. University of the Sciences in Philadelphia; 2020. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=22620871

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

West Virginia University

27. Nadpara, Pramit Amrutlal. Patterns of Lung Cancer Care and Associated Health Outcomes Among Elderly Medicare Fee For Service Beneficiaries in West Virginia and in the United States.

Degree: PhD, Pharmaceutical Systems and Policy, 2013, West Virginia University

URL: https://doi.org/10.33915/etd.4984 ; https://researchrepository.wvu.edu/etd/4984

► The elderly carry a disproportionate burden of lung cancer in the US. Although significant improvements have been made during the past decade in cancer treatment,… (more)

▼ The elderly carry a disproportionate burden of lung cancer in the US. Although significant improvements have been made during the past decade in cancer treatment, substantial disparities still exist in guideline-based lung cancer care and outcomes. Such variation in lung cancer care is a cause for major concern in rural areas like West Virginia (WV). The purpose of this study was to do a comprehensive evaluation of variations in lung cancer care and associated health outcomes in the elderly. This retrospective study was conducted using SEER-Medicare and WVCR – Medicare linked data files for the years 2002-2007. As part of the project, three studies were conducted. In the first study, we compared geographic variations in clinical guideline-based lung cancer care and associated health outcomes among elderly Medicare Fee-for-service (FFS) beneficiaries. The study found disparities in receipt of minimally appropriate care in both the WV and US populations. Receipt of minimally appropriate care was found to be associated with longer survival times. In the second study, we compared geographic variations in timeliness of lung cancer care and found significant variation in delays in diagnosis and treatment in both the WV and US populations. However, non-timely care was not associated with poorer prognosis. The third study determined the patterns of receipt of tobacco-use cessation counseling services and found such services to be received by more than half of all beneficiaries. Overall, the findings highlight the critical need to address disparities in receipt of guideline-based appropriate and timely lung cancer care among Medicare FFS beneficiaries. The findings also reveals the urgent need for future cancer prevention efforts directed towards promoting smoking cessation in the rural WV population. In the long run, such cancer prevention efforts can help to reduce lung cancer incidence, which in turn can help to reduce the geographic disparities in lung cancer mortality. Advisors/Committee Members: S Suresh Madhavan, Mohammed Almubarak, Michael Hendryx.

Subjects/Keywords: Pharmaceutical sciences

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APA (6^th Edition):

Nadpara, P. A. (2013). Patterns of Lung Cancer Care and Associated Health Outcomes Among Elderly Medicare Fee For Service Beneficiaries in West Virginia and in the United States. (Doctoral Dissertation). West Virginia University. Retrieved from https://doi.org/10.33915/etd.4984 ; https://researchrepository.wvu.edu/etd/4984

Chicago Manual of Style (16^th Edition):

Nadpara, Pramit Amrutlal. “Patterns of Lung Cancer Care and Associated Health Outcomes Among Elderly Medicare Fee For Service Beneficiaries in West Virginia and in the United States.” 2013. Doctoral Dissertation, West Virginia University. Accessed March 02, 2021. https://doi.org/10.33915/etd.4984 ; https://researchrepository.wvu.edu/etd/4984.

MLA Handbook (7^th Edition):

Nadpara, Pramit Amrutlal. “Patterns of Lung Cancer Care and Associated Health Outcomes Among Elderly Medicare Fee For Service Beneficiaries in West Virginia and in the United States.” 2013. Web. 02 Mar 2021.

Vancouver:

Nadpara PA. Patterns of Lung Cancer Care and Associated Health Outcomes Among Elderly Medicare Fee For Service Beneficiaries in West Virginia and in the United States. [Internet] [Doctoral dissertation]. West Virginia University; 2013. [cited 2021 Mar 02]. Available from: https://doi.org/10.33915/etd.4984 ; https://researchrepository.wvu.edu/etd/4984.

Council of Science Editors:

Nadpara PA. Patterns of Lung Cancer Care and Associated Health Outcomes Among Elderly Medicare Fee For Service Beneficiaries in West Virginia and in the United States. [Doctoral Dissertation]. West Virginia University; 2013. Available from: https://doi.org/10.33915/etd.4984 ; https://researchrepository.wvu.edu/etd/4984

West Virginia University

28. Peirce, Gretchen L. Controlled Drug Substance Use in West Virginia: An investigation into Doctor Shopping, Pharmacy Shopping, And Prescription Histories.

Degree: MS, Pharmaceutical Systems and Policy, 2011, West Virginia University

URL: https://doi.org/10.33915/etd.4766 ; https://researchrepository.wvu.edu/etd/4766

► One objective was to compare the proportion of doctor and pharmacy shoppers between living and deceased users of controlled drug substances (CDS) in West Virginia.… (more)

▼ One objective was to compare the proportion of doctor and pharmacy shoppers between living and deceased users of controlled drug substances (CDS) in West Virginia. A second objective was to identify factors that predict the odds a subject is classified as a shopper. A third objective was to determine factors that predict the odds of dying from CDS use. A final objective was to identify factors that predict the odds of deceased subjects not having verified prescriptions for CDS detected upon autopsy.;A secondary data research study was conducted. The Controlled Drug Substance Monitoring Program and the Forensic Drug Database were used to identify subjects who were 18 years or older and used Schedule II-IV controlled drug substances in the state of West Virginia from July, 1, 2005 to December 31, 2007. Bivariate analyses were used to compare living and deceased subjects for both doctor shopping and pharmacy shopping. Logistic regression was conducted to predict the odds of doctor shopping, pharmacy shopping, and of dying related to CDS use. Bivariate analyses were used to compare decedents with versus without verified prescriptions for CDS detected upon autopsy. Logistic regression was conducted to predict the odds that a decedent did not have verified prescriptions for all CDS detected upon autopsy.;Approximately 25.36% of deceased subjects and 3.61% of living subjects were doctor shoppers. Approximately 17.91% of deceased subjects and 1.31% of living subjects were pharmacy shoppers. Furthermore, 7,778 subjects were considered both doctor and pharmacy shoppers (20.31% of doctor shoppers were also pharmacy shoppers, and 55.83% of pharmacy shoppers were also doctor shoppers). Age, number of different CDS dispensed, number of prescriptions dispensed, and number of pharmacies visited significantly predicted the odds of being classified as a doctor shopper. Life status, age, number of different CDS dispensed, number of prescriptions dispensed, and number of doctors visited significantly predicted the odds of being classified as a pharmacy shopper. Age, number of different CDS dispensed, number of prescriptions dispensed, and number of pharmacies visited significantly predicted the odds of dying. Approximately 30% of decedents had a verified prescription for all their CDS detected upon autopsy. Age, number of different CDS at autopsy, and gender significantly predicted the odds of being classified as not having verified prescriptions for all CDS detected upon autopsy.;In conclusion, there is evidence of doctor shopping and pharmacy shopping for controlled drug substances in West Virginia. Interventions by healthcare professionals are important because only a third of decedents had a verifiable prescription for all their CDS detected upon autopsy. Pharmacists as well as physicians may rely on a prescription monitoring program to identify shoppers. Healthcare professionals should consider integrating prescription monitoring program information during delivery of care, and evaluate its impact in preventing drug-induced and… Advisors/Committee Members: Joel Halverson, Michael J Smith.

Subjects/Keywords: Pharmaceutical sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Peirce, G. L. (2011). Controlled Drug Substance Use in West Virginia: An investigation into Doctor Shopping, Pharmacy Shopping, And Prescription Histories. (Thesis). West Virginia University. Retrieved from https://doi.org/10.33915/etd.4766 ; https://researchrepository.wvu.edu/etd/4766

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Peirce, Gretchen L. “Controlled Drug Substance Use in West Virginia: An investigation into Doctor Shopping, Pharmacy Shopping, And Prescription Histories.” 2011. Thesis, West Virginia University. Accessed March 02, 2021. https://doi.org/10.33915/etd.4766 ; https://researchrepository.wvu.edu/etd/4766.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Peirce, Gretchen L. “Controlled Drug Substance Use in West Virginia: An investigation into Doctor Shopping, Pharmacy Shopping, And Prescription Histories.” 2011. Web. 02 Mar 2021.

Vancouver:

Peirce GL. Controlled Drug Substance Use in West Virginia: An investigation into Doctor Shopping, Pharmacy Shopping, And Prescription Histories. [Internet] [Thesis]. West Virginia University; 2011. [cited 2021 Mar 02]. Available from: https://doi.org/10.33915/etd.4766 ; https://researchrepository.wvu.edu/etd/4766.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Peirce GL. Controlled Drug Substance Use in West Virginia: An investigation into Doctor Shopping, Pharmacy Shopping, And Prescription Histories. [Thesis]. West Virginia University; 2011. Available from: https://doi.org/10.33915/etd.4766 ; https://researchrepository.wvu.edu/etd/4766

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

West Virginia University

29. Bhanegaonkar, Abhijeet J. Patient Preferences for Benefits and Risks Associated with Disease Modifying Drugs in Multiple Sclerosis.

Degree: PhD, Pharmaceutical Sciences, 2012, West Virginia University

URL: https://doi.org/10.33915/etd.4833 ; https://researchrepository.wvu.edu/etd/4833

► Multiple sclerosis (MS) is a chronic inflammatory demyelinating neurological disorder with no known cure. Disease modifying drugs (DMDs) used in the treatment of MS reduce… (more)

▼ Multiple sclerosis (MS) is a chronic inflammatory demyelinating neurological disorder with no known cure. Disease modifying drugs (DMDs) used in the treatment of MS reduce the frequency relapses and delay the progression of the disease. Although DMD therapy is the mainstay of treatment of MS, it is associated with variety of side effects and severe adverse events. A majority of currently available DMDs are injectable, except one which is available in the pill form. Therapeutic decisions in MS are challenging due to the inconvenience of administration, frequency of administration, longer duration of therapy, side effects, and risk of adverse events associated with DMDs. The purpose of this series of studies was to better understand different aspects of DMDs from patients' point of view. A total of three studies were conducted using qualitative and quantitative research methods. Data for the first study were collected using focus group interviews among eighteen MS patients attending neurology clinic affiliated to a teaching hospital. Study two and study three were performed using a web-based survey questionnaire in a sample of MS patients residing in the United States using a cross-sectional study design. The specific objectives are the three studies were: 1) To explore patients' experiences, opinions, and expectations related to DMDs used in MS, 2) to estimate preference weights and relative importance of attributes for DMDs used in MS treatment using conjoint analysis, and 3) to assess disease and treatment related factors associated satisfaction with treatment among MS patients. Participants in the first study had an understanding of importance of DMDs in the therapeutic management of MS. MS patients reported to adapt themselves to available DMD choices, but had greater expectations from emerging DMDs. Participants reported that the convenience of DMD administration, occurrence of relapses, delay of disability progression were important factors related to DMD; however, most were concerned about the side-effects that affected day-to-day functioning and the adverse events associated with DMDs. The results of the second study revealed that attributes indicating risks associated with DMDs (progressive multifocal leukoencephalopathy and severe liver dysfunction) were the most important attributes followed flu-like symptoms, delaying disability progression, frequency of relapses, and mode of DMD administration. Strength of evidence on treatment outcomes expressed in number of years was the least important attribute to patients. The results of the third study indicated that factors such as type of current DMD used, relapses experienced, disability status, total number of MS symptoms experienced, and past experiences with DMDS were associated with lower treatment satisfaction scores. Advisors/Committee Members: S Suresh Madhavan.

Subjects/Keywords: Pharmaceutical sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bhanegaonkar, A. J. (2012). Patient Preferences for Benefits and Risks Associated with Disease Modifying Drugs in Multiple Sclerosis. (Doctoral Dissertation). West Virginia University. Retrieved from https://doi.org/10.33915/etd.4833 ; https://researchrepository.wvu.edu/etd/4833

Chicago Manual of Style (16^th Edition):

Bhanegaonkar, Abhijeet J. “Patient Preferences for Benefits and Risks Associated with Disease Modifying Drugs in Multiple Sclerosis.” 2012. Doctoral Dissertation, West Virginia University. Accessed March 02, 2021. https://doi.org/10.33915/etd.4833 ; https://researchrepository.wvu.edu/etd/4833.

MLA Handbook (7^th Edition):

Bhanegaonkar, Abhijeet J. “Patient Preferences for Benefits and Risks Associated with Disease Modifying Drugs in Multiple Sclerosis.” 2012. Web. 02 Mar 2021.

Vancouver:

Bhanegaonkar AJ. Patient Preferences for Benefits and Risks Associated with Disease Modifying Drugs in Multiple Sclerosis. [Internet] [Doctoral dissertation]. West Virginia University; 2012. [cited 2021 Mar 02]. Available from: https://doi.org/10.33915/etd.4833 ; https://researchrepository.wvu.edu/etd/4833.

Council of Science Editors:

Bhanegaonkar AJ. Patient Preferences for Benefits and Risks Associated with Disease Modifying Drugs in Multiple Sclerosis. [Doctoral Dissertation]. West Virginia University; 2012. Available from: https://doi.org/10.33915/etd.4833 ; https://researchrepository.wvu.edu/etd/4833

West Virginia University

30. Seminerio, Michael. Pharmacological Characterization of an Optimized Sigma Receptor Ligand.

Degree: PhD, Pharmaceutical Sciences, 2012, West Virginia University

URL: https://doi.org/10.33915/etd.3561 ; https://researchrepository.wvu.edu/etd/3561

► Methamphetamine is an addictive psychostimulant drug with an increasing prevalence of abuse worldwide. Recent evidence has linked methamphetamine exposure to a wide array of neurological… (more)

▼ Methamphetamine is an addictive psychostimulant drug with an increasing prevalence of abuse worldwide. Recent evidence has linked methamphetamine exposure to a wide array of neurological complications some of which lead to neurodegenerative changes in the brain and hyperthermia. Currently, there are no FDA approved pharmacologic agents to treat the effects of methamphetamine. Recent evidence has suggested methamphetamine may, in part, produce some of its effects through sigma receptors making them a potential target for pharmacological intervention. While our lab has shown a number of selective sigma receptor ligands can provide neuroprotection against the neurotoxic and behavioral effects of methamphetamine, limitations such as metabolic instability have prevented the advancement of any lead compound to ladder drug development studies. To address this issue and pursue a lead therapeutic compound to aid against methamphetamine-induced complications, CM156, a previously studied selective sigma receptor ligand, was optimized for metabolic stability. Following the synthesis and evaluation of thirty CM156 analogs, a lead compound was identified. Radioligand binding studies demonstrated the lead analog, AZ66, displayed high nanomolar affinity for both sigma-1 and sigma-2 receptors (2.4 +/- 0.63 and 0.51 +/- 0.15, respectively). In addition, AZ66 had preferential affinity for sigma receptors compared to sixty-four other sites and a significantly longer half life than its predecessor, CM156, in vitro and in vivo. To further characterize AZ66 as a potential lead compound, we evaluated AZ66 against the neurotoxic, behavioral, and cognitive effects produced by methamphetamine. Pretreatment of male, Swiss Webster mice with intraperitoneal (10-20 mg/kg) or oral (20-30 mg/kg) dosing of AZ66significantly attenuated the acute locomotor stimulatory effects of methamphetamine in addition to reducing the expression and development of behavioral sensitization induced by repeated methamphetamine administration. Furthermore, AZ66 significantly attenuated methamphetamine-induced striatal dopamine depletions, striatal dopamine transporter reductions, and hyperthermia. Additionally, neurotoxic dosing with methamphetamine caused significant memory impairment in the object recognition test which was attenuated when animals were pretreated with AZ66; similar trends were observed in the step-through passive avoidance test. The studies presented herein demonstrate that targeting sigma receptors can provide neuroprotective effects against methamphetamine and AZ66 may represent a promising lead compound for developing future therapeutics. Advisors/Committee Members: Rae R. Matsumoto..

Subjects/Keywords: Pharmaceutical sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Seminerio, M. (2012). Pharmacological Characterization of an Optimized Sigma Receptor Ligand. (Doctoral Dissertation). West Virginia University. Retrieved from https://doi.org/10.33915/etd.3561 ; https://researchrepository.wvu.edu/etd/3561

Chicago Manual of Style (16^th Edition):

Seminerio, Michael. “Pharmacological Characterization of an Optimized Sigma Receptor Ligand.” 2012. Doctoral Dissertation, West Virginia University. Accessed March 02, 2021. https://doi.org/10.33915/etd.3561 ; https://researchrepository.wvu.edu/etd/3561.

MLA Handbook (7^th Edition):

Seminerio, Michael. “Pharmacological Characterization of an Optimized Sigma Receptor Ligand.” 2012. Web. 02 Mar 2021.

Vancouver:

Seminerio M. Pharmacological Characterization of an Optimized Sigma Receptor Ligand. [Internet] [Doctoral dissertation]. West Virginia University; 2012. [cited 2021 Mar 02]. Available from: https://doi.org/10.33915/etd.3561 ; https://researchrepository.wvu.edu/etd/3561.

Council of Science Editors:

Seminerio M. Pharmacological Characterization of an Optimized Sigma Receptor Ligand. [Doctoral Dissertation]. West Virginia University; 2012. Available from: https://doi.org/10.33915/etd.3561 ; https://researchrepository.wvu.edu/etd/3561

Open Access Theses and Dissertations