subject:(Pharmaceutical sciences)

University of Washington

1. Tung, Amy. Characterizing Healthcare Utilization, Direct Costs, and Comorbidities Associated with Interstitial Cystitis: A Retrospective Claims Analysis.

Degree: 2016, University of Washington

URL: http://hdl.handle.net/1773/36463

► Introduction Interstitial Cystitis (IC) is a debilitating condition that affects up to five percent of the United States (US) population.1 The condition is characterized by… (more)

▼ Introduction Interstitial Cystitis (IC) is a debilitating condition that affects up to five percent of the United States (US) population.1 The condition is characterized by bladder pain, urinary urgency and frequency, and in some patients, bladder lesions called Hunner’s Lesions (HL). Patients with HL experience a clinical course distinctly different from patients without HL.2 Prior research describing the burden of IC is outdated and lacks HL-level detail. This study aims to characterize healthcare utilization, direct costs, and comorbidities associated with IC, and among IC patients, elucidate differences between those with and without HL. Methods A retrospective analysis was conducted using healthcare claims from the Truven Health MarketScan® Research Databases. Adults with an incident IC diagnosis between 2009 and 2014 were identified and matched to non-IC patients on age, gender, and geographic region. Healthcare utilization, direct costs, and comorbidities during the first 12 months after diagnosis were compared between the two groups, as well as between IC subgroups with and without HL. Results IC patients (n=24,836) were predominantly (92%) female, with a mean age of 49.0 (SD = 15.3) years. IC patients utilized significantly more healthcare resources across all categories compared to non-IC patients. On average, having IC was associated with 6,798 higher total healthcare costs than not having IC (95% CI: 6,253, 7,343), with outpatient costs contributing to 71% of the difference, after adjusting for baseline age, gender, region, insurance type, plan type, and CCI. The odds of developing IC-related comorbidities were 2.61 times greater in IC patients compared to non-IC patients (95% CI: 2.52, 2.70), adjusting for baseline age, sex, region, and CCI. Among IC patients, the HL subgroup (n=292) utilized more healthcare resources, and having HL was associated with 6,486 higher total healthcare costs compared to not having HL (95% CI: 3,497, 9,475) after adjusting for baseline age, gender, region, insurance type, and plan type. Conclusion Our findings suggest that patients with IC have significantly higher healthcare utilization, costs, and comorbidities compared to non-IC patients. This economic burden is further amplified in those with HL. Advisors/Committee Members: Devine, Emily B (advisor).

Subjects/Keywords:

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APA (6^th Edition):

Tung, A. (2016). Characterizing Healthcare Utilization, Direct Costs, and Comorbidities Associated with Interstitial Cystitis: A Retrospective Claims Analysis. (Thesis). University of Washington. Retrieved from http://hdl.handle.net/1773/36463

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tung, Amy. “Characterizing Healthcare Utilization, Direct Costs, and Comorbidities Associated with Interstitial Cystitis: A Retrospective Claims Analysis.” 2016. Thesis, University of Washington. Accessed February 25, 2020. http://hdl.handle.net/1773/36463.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tung, Amy. “Characterizing Healthcare Utilization, Direct Costs, and Comorbidities Associated with Interstitial Cystitis: A Retrospective Claims Analysis.” 2016. Web. 25 Feb 2020.

Vancouver:

Tung A. Characterizing Healthcare Utilization, Direct Costs, and Comorbidities Associated with Interstitial Cystitis: A Retrospective Claims Analysis. [Internet] [Thesis]. University of Washington; 2016. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/1773/36463.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tung A. Characterizing Healthcare Utilization, Direct Costs, and Comorbidities Associated with Interstitial Cystitis: A Retrospective Claims Analysis. [Thesis]. University of Washington; 2016. Available from: http://hdl.handle.net/1773/36463

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Yadlapalli, Jai Shankar K. Preclinical evaluation of the 6-O-sulfate ester of morphine for the treatment of multimodal acute and chronic pain.

Degree: 2015, University of Arkansas for Medical Sciences

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3721351

► Chronic pain is a huge economic burden and a devastating complication requiring therapeutic interventions. This dissertation evaluated the analgesic potency, efficacy, tolerance and cross-tolerance… (more)

▼ Chronic pain is a huge economic burden and a devastating complication requiring therapeutic interventions. This dissertation evaluated the analgesic potency, efficacy, tolerance and cross-tolerance profile of morphine and its ester derivative, morphine-6-O-sulfate (M6S) in a rat model of diabetic neuropathy, and in normal rats utilizing a multimodal pain domain approach (e.g., burning pain, pricking pain, and deep muscle pain). Diabetes was induced in male Sprague-Dawley rats with streptozotocin, 65mg/kg (intraperitoneally). Hot water tail-flick latency, paw pressure, pinprick sensitivity and hot plate withdrawal thresholds (HTL, PPT, PST and HPT) were measured at various time points and doses after i.p. injection (N=6) on days 1, 3, 7, 9, 12, 19, 25 and 29 of treatment in both normal and diabetic rats. Affinity binding studies, GTPγ S assays and intracellular cAMP assays were performed in Chinese hamster ovary cells transfected with human mu (μ) - or delta (δ)-opioid receptors (N=5). HPLC-DAD stability studies were performed in vitro in various pH buffers and biological fluids (N=4). Pharmacokinetic parameters for M6S were studied using intravenous (1 mg/kg), intraperitoneal (i.p. 5.6, 10 mg/kg) and oral routes (10, 30 mg/kg) of drug administration (N=4 to 7 for each dose). Compared to morphine, in diabetic animals, M6S was 12-fold more potent in the HPT test (ED₅₀ M6S = 1.1 ± 0.02 μmol/kg Vs ED₅₀ MOR=12.1 ± 1.8 μmol/kg; p< 0.05), and 20-times more potent in the HTL test (in diabetic rats, ED₅₀ M6S = 1.1 ± 0.02 μmol/kg Vs ED₅₀ MOR = 12.1 ± 1.8 μmol/kg; p< 0.001). In the PST test, M6S was 3-fold more potent than morphine in diabetic rats (ED₅₀ M6S = 6.9 ± 1.46 μmol/kg Vs ED₅₀ MOR = 16.2 ± 1.24 μmol/kg). Similar potency differences were also observed between morphine and M6S in normal rats. Diabetes caused a decrease in potency (about 3-5 fold) of morphine in the HPT and HTF tests and a loss of efficacy in the PST and PPT tests (4^th week of diabetes) without significantly effecting M6S potency and efficacy in all these tests. Furthermore, 9 vs. 28 days of chronic treatment were required for rats to become tolerant to morphine and M6S, respectively, in the HTF and HPT tests. M6S also sustained its potent analgesic effects in morphine-tolerant rats (i.e. no cross-tolerance) and demonstrated clinical potential as an opioid rotation drug in morphine-tolerant subjects. With no significant differences in binding, activation of GTPγ and inhibition of cAMP at the μ-opioid receptor, M6S activated G-proteins via δ-ORs more potently than morphine (e.g., M6S-ED₅₀ = 101 ± 41.6 nM; MOR-ED₅₀ = 785 ± 140 nM), and modulated adenylyl cyclase activity via δ-ORs in intact CHO-hDOR cells more potently than morphine (e.g., M6S-ED₅₀ = 55.1 ± 17.5 nM; MOR-ED₅₀…

Subjects/Keywords: Pharmaceutical sciences

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APA (6^th Edition):

Yadlapalli, J. S. K. (2015). Preclinical evaluation of the 6-O-sulfate ester of morphine for the treatment of multimodal acute and chronic pain. (Thesis). University of Arkansas for Medical Sciences. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3721351

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yadlapalli, Jai Shankar K. “Preclinical evaluation of the 6-O-sulfate ester of morphine for the treatment of multimodal acute and chronic pain.” 2015. Thesis, University of Arkansas for Medical Sciences. Accessed February 25, 2020. http://pqdtopen.proquest.com/#viewpdf?dispub=3721351.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yadlapalli, Jai Shankar K. “Preclinical evaluation of the 6-O-sulfate ester of morphine for the treatment of multimodal acute and chronic pain.” 2015. Web. 25 Feb 2020.

Vancouver:

Yadlapalli JSK. Preclinical evaluation of the 6-O-sulfate ester of morphine for the treatment of multimodal acute and chronic pain. [Internet] [Thesis]. University of Arkansas for Medical Sciences; 2015. [cited 2020 Feb 25]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3721351.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yadlapalli JSK. Preclinical evaluation of the 6-O-sulfate ester of morphine for the treatment of multimodal acute and chronic pain. [Thesis]. University of Arkansas for Medical Sciences; 2015. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3721351

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Temple University

3. Lu, Zheng. DEVELOPMENT OF SUPERSATURATED MATRIX SYSTEMS FOR POORLY WATER-SOLUBLE COMPOUNDS BASED ON SPRAY-DRIED SOLID DISPERSIONS.

Degree: PhD, 2017, Temple University

URL: http://digital.library.temple.edu/u?/p245801coll10,463548

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Pharmaceutical Sciences

The objective of this study was to design, develop and evaluate an amorphous solid dispersion (ASD)-loaded controlled release (CR) matrix system for poorly… (more)

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Pharmaceutical Sciences

The objective of this study was to design, develop and evaluate an amorphous solid dispersion (ASD)-loaded controlled release (CR) matrix system for poorly water-soluble drug in order to enhance its solubility and dissolution rate while maintaining the stability of the supersaturated state during and after dissolution. Two types of polymeric carriers, namely hydroxypropyl methylcellulose acetate succinate (HPMCAS) and copovidone S-630, were used in spary-dried dispersion (SDD) formulations. Weak acid drugs glipizide and gliclazide which tend to have limited solubility and dissolution rate were chosen as poorly soluble model compounds representing Class-II drugs according to the FDA adopted Biopharmaceutics Classification Scheme. The unique features of the hydrating CR matrix system consisting of amorphous drug dispersion that provides supersaturation and probable mechanisms to inhibit precipitation are investigated. SDD-loaded CR matrix tablets prepared in this study were based on use of automated spray dryer and compaction simulator with optimized process parameters in order to control the critical quality attributes (CQAs) of final formulations. A 3×4 full factorial design was conducted to understand the effect of drug loading level and polymer type on the performance of SDD products for both glipizide and gliclazide. Drug loading level and succinoyl content % of HPMCAS were identified as two critical factors for meeting goals set to achieve maximum concentration under non-sink condition referred to as Cmax. Compliance to Cmax limit is assured by selecting drug loading level and type of HPMCAS within design space. Spray-dried dispersions (SDDs) of glipizide and gliclazide were prepared using HPMCAS (H, M and L grades) and copovidone as amorphous matrix forming polymer in order to improve the solubility and dissolution rate of the drug. The SDDs appeared as a single amorphous phase with up to 60% drug loading level as revealed by X-ray powder diffraction (XRPD), modulated differential scanning calorimetry (mDSC) and scanning electron microscopy (SEM). Supersaturated micro-dissolution testing of SDD powders in fasted state simulated intestinal fluid showed prolonged supersaturation state (up to 180 minutes) with significant solubility increase relative to crystalline drug under same conditions. Moreover, plot of relative dissolution AUCs (AUC (SDD) /AUC (crystalline)) versus stable supersaturated concentration ratio (C180/Cmax) was provided as an appropriate formulation strategy for selecting SDDs with improved solubility and supersaturation stability. Selected SDDs were formulated into matrix tablet with rate-controlling hydrophilic polymer, hydroxypropylmethylcellulose (HPMC) and other excipients. Dissolution data based on standard USP paddle method indicated that SDD-loaded CR tablets provide stable supersaturated concentration within the hydrated matrix with increased rate and extent of drug dissolution. Co-existence of HPMCAS and HPMC within the hydrating matrix showed strong…

Advisors/Committee Members: Fassihi, Reza;, Canney, Daniel J., Ilies, Marc A., Wong, Ho-Lun, Hussain, Munir;.

Subjects/Keywords: Pharmaceutical sciences

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APA (6^th Edition):

Lu, Z. (2017). DEVELOPMENT OF SUPERSATURATED MATRIX SYSTEMS FOR POORLY WATER-SOLUBLE COMPOUNDS BASED ON SPRAY-DRIED SOLID DISPERSIONS. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,463548

Chicago Manual of Style (16^th Edition):

Lu, Zheng. “DEVELOPMENT OF SUPERSATURATED MATRIX SYSTEMS FOR POORLY WATER-SOLUBLE COMPOUNDS BASED ON SPRAY-DRIED SOLID DISPERSIONS.” 2017. Doctoral Dissertation, Temple University. Accessed February 25, 2020. http://digital.library.temple.edu/u?/p245801coll10,463548.

MLA Handbook (7^th Edition):

Lu, Zheng. “DEVELOPMENT OF SUPERSATURATED MATRIX SYSTEMS FOR POORLY WATER-SOLUBLE COMPOUNDS BASED ON SPRAY-DRIED SOLID DISPERSIONS.” 2017. Web. 25 Feb 2020.

Vancouver:

Lu Z. DEVELOPMENT OF SUPERSATURATED MATRIX SYSTEMS FOR POORLY WATER-SOLUBLE COMPOUNDS BASED ON SPRAY-DRIED SOLID DISPERSIONS. [Internet] [Doctoral dissertation]. Temple University; 2017. [cited 2020 Feb 25]. Available from: http://digital.library.temple.edu/u?/p245801coll10,463548.

Council of Science Editors:

Lu Z. DEVELOPMENT OF SUPERSATURATED MATRIX SYSTEMS FOR POORLY WATER-SOLUBLE COMPOUNDS BASED ON SPRAY-DRIED SOLID DISPERSIONS. [Doctoral Dissertation]. Temple University; 2017. Available from: http://digital.library.temple.edu/u?/p245801coll10,463548

Temple University

4. AKOCAK, SULEYMAN. Design and delivery of selective inhibitors of tumor overexpressed isozymes of carbonic anhydrase- towards new theranostic systems for cancer detection and treatment.

Degree: PhD, 2014, Temple University

URL: http://digital.library.temple.edu/u?/p245801coll10,282694

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Pharmaceutical Sciences

Cancer is the second most common cause of death and a major cause of mortality in the world. The high mortality associated with… (more)

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Pharmaceutical Sciences

Cancer is the second most common cause of death and a major cause of mortality in the world. The high mortality associated with cancer is due to the fact that usually it is discovered too late, when it is metastasized to different organs and is very hard to cure. Finding more efficient, convenient and selective ways for early diagnosis and eradication of pre-malignant or malignant tumors of small dimensions is a task of utmost importance. The development of many malignant tumors was associated with hypoxia and the over-expression of specific membrane-bound carbonic anhydrase (CA) isozymes CA IX and CA XII. Malignant tissue of relatively small dimensions can grow fast and can invade the surrounding tissues by reverting to anaerobic metabolism and by acidifying the extracellular milieu around the tumor, increasing its invasiveness. Our goal is to detect and treat malignant hypoxic tumors using selective inhibitors of CA IX and CA XII and the objective of this thesis was to develop selective and efficient carbonic anhydrase inhibitors (CAIs) for the tumoral CA IX and CA XII that will leave unaltered the normal tissues. Two new sets of membrane-impermeant carbonic anhydrase inhibitors are proposed to be developed based on pyridinium positively-charged moieties attached to know CAI pharmacophores. Our guiding hypothesis was that modulation of carbonic anhydrase potency and tissue penetrability is possible to be achieved via fine tuning of pyridinium substitution. The use of appropriate substitutents on the pyridinium ring allowed the creation of CAI with special optical properties (e.g. fluorescence). The rationale for the research summarized in this thesis was that a CAI selective for membrane isozymes CA IX and CA XII over-expressed in cancer with controlled tissue penetrability can open new avenues in cancer early detection and treatment that will complement and/or potentiate present technologies and therapies.

Temple University – Theses

Advisors/Committee Members: Ilies, Marc A.;, Borenstein, Michael R., Canney, Daniel J., Mesaros, Eugen;.

Subjects/Keywords: Pharmaceutical sciences

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APA (6^th Edition):

AKOCAK, S. (2014). Design and delivery of selective inhibitors of tumor overexpressed isozymes of carbonic anhydrase- towards new theranostic systems for cancer detection and treatment. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,282694

Chicago Manual of Style (16^th Edition):

AKOCAK, SULEYMAN. “Design and delivery of selective inhibitors of tumor overexpressed isozymes of carbonic anhydrase- towards new theranostic systems for cancer detection and treatment.” 2014. Doctoral Dissertation, Temple University. Accessed February 25, 2020. http://digital.library.temple.edu/u?/p245801coll10,282694.

MLA Handbook (7^th Edition):

AKOCAK, SULEYMAN. “Design and delivery of selective inhibitors of tumor overexpressed isozymes of carbonic anhydrase- towards new theranostic systems for cancer detection and treatment.” 2014. Web. 25 Feb 2020.

Vancouver:

AKOCAK S. Design and delivery of selective inhibitors of tumor overexpressed isozymes of carbonic anhydrase- towards new theranostic systems for cancer detection and treatment. [Internet] [Doctoral dissertation]. Temple University; 2014. [cited 2020 Feb 25]. Available from: http://digital.library.temple.edu/u?/p245801coll10,282694.

Council of Science Editors:

AKOCAK S. Design and delivery of selective inhibitors of tumor overexpressed isozymes of carbonic anhydrase- towards new theranostic systems for cancer detection and treatment. [Doctoral Dissertation]. Temple University; 2014. Available from: http://digital.library.temple.edu/u?/p245801coll10,282694

Temple University

5. Fan, Rong. DESIGN, SYNTHESIS, AND EVALUATION OF 5-LIPOXYGENASE INHIBITOR PRODRUGS FOR ALZHEIMER’S DISEASE.

Degree: PhD, 2016, Temple University

URL: http://digital.library.temple.edu/u?/p245801coll10,408778

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Pharmaceutical Sciences

Pharmacologic blockade of 5-Lipoxygenase (5-LO) through its inhibitor, zileuton (Zyflo®), has been shown to reduce both gamma secretase-catalyzed misprocessing of amyloid precursor protein… (more)

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Pharmaceutical Sciences

Pharmacologic blockade of 5-Lipoxygenase (5-LO) through its inhibitor, zileuton (Zyflo®), has been shown to reduce both gamma secretase-catalyzed misprocessing of amyloid precursor protein and over-phosphorylation of tau protein (two hallmarks of Alzheimer’s disease (AD)) in transgenic mice (3xTg, Tg2576). However, zileuton suffers from low potency, liver toxicity, gastrointestinal side effects, and a suboptimal metabolism profile that hamper its development as a viable disease-modifying treatment for AD patients, who are usually older. Prodrugs of zileuton that deliver therapeutic concentrations of the parent molecule to the brain at low plasma concentrations could overcome these problems. In addition, other 5-LO inhibitors (ABT-761, BWA4C) with similar structure but greater potency might also be amenable to facilitate the discovery of the best prodrug for AD. A prodrug is a biologically inactive compound that is metabolized in the target tissue to release the parent drug. Prodrug strategies for Central Nervous System (CNS) delivery include masking polar groups with lipophilic moieties that promote brain penetration, Chemical Delivery Systems (CDS) that trap prodrugs in the brain and incorporating brain nutrients which engage Blood Brain Barrier (BBB) nutrient transporters. We have pursued all three strategies to enhance CNS delivery of the prototype hydroxyurea 5-LO inhibitor analog zileuton. To accomplish this task we synthesized and characterized 48 5-LO prodrugs for zileuton that falls into all three prodrug categories, and several lipophilic and CDS prodrugs for the other two 5-LO inhibitors (22 for ABT-761 and 22 for BWA4C,). The prodrugs were tested in a battery of in vitro assays that included solubility, plasma/simulated gastrointestinal fluid/microsomal stability, cell toxicity, and 5-LO inhibition assays. The promising compounds then went to the second tier of screening by equilibrium dialysis with plasma/brain homogenate/microsomes, and in vivo pilot pharmacokinetics study and full pharmacokinetics studies. As a consequence of this work, we identified six zileuton prodrugs (RF14, RF15, RF75, RF77, RF87, and RF88) with reasonable solubility, stability, safety, protein/lipid binding, and no 5-LO inhibitory activities and advanced them to the in vivo pilot pharmacokinetics studies. The most lipophilic prodrug RF58 was also tested in vivo as a comparator to RF14 and RF15 despite its fast metabolism in plasma. However, none of them demonstrated better CNS delivery of parent drug compared to administration of the parent itself. For the lipophilic prodrugs, two carbamate prodrugs (the racemic mixture of RF14 and RF15, RF58) were tested in the in vivo pilot study. The racemic mixture of RF14 and RF15 (RF14/15) with slightly increased lipophilicity (CLogP = 2.81 compared to 2.48 of zileuton) didn’t demonstrate a better brain penetration (Brain/Plasma = 0.06 in RF14/RF15 compared to 0.5 for zileuton). In addition, the carbamate linker was relatively stable in the brain, which resulted in…

Advisors/Committee Members: Childers, Wayne;, Canney, Daniel J., Abou-Gharbia, Magid, Korzekwa, Kenneth, Harrison, Boyd L.;.

Subjects/Keywords: Pharmaceutical sciences

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APA (6^th Edition):

Fan, R. (2016). DESIGN, SYNTHESIS, AND EVALUATION OF 5-LIPOXYGENASE INHIBITOR PRODRUGS FOR ALZHEIMER’S DISEASE. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,408778

Chicago Manual of Style (16^th Edition):

Fan, Rong. “DESIGN, SYNTHESIS, AND EVALUATION OF 5-LIPOXYGENASE INHIBITOR PRODRUGS FOR ALZHEIMER’S DISEASE.” 2016. Doctoral Dissertation, Temple University. Accessed February 25, 2020. http://digital.library.temple.edu/u?/p245801coll10,408778.

MLA Handbook (7^th Edition):

Fan, Rong. “DESIGN, SYNTHESIS, AND EVALUATION OF 5-LIPOXYGENASE INHIBITOR PRODRUGS FOR ALZHEIMER’S DISEASE.” 2016. Web. 25 Feb 2020.

Vancouver:

Fan R. DESIGN, SYNTHESIS, AND EVALUATION OF 5-LIPOXYGENASE INHIBITOR PRODRUGS FOR ALZHEIMER’S DISEASE. [Internet] [Doctoral dissertation]. Temple University; 2016. [cited 2020 Feb 25]. Available from: http://digital.library.temple.edu/u?/p245801coll10,408778.

Council of Science Editors:

Fan R. DESIGN, SYNTHESIS, AND EVALUATION OF 5-LIPOXYGENASE INHIBITOR PRODRUGS FOR ALZHEIMER’S DISEASE. [Doctoral Dissertation]. Temple University; 2016. Available from: http://digital.library.temple.edu/u?/p245801coll10,408778

Temple University

6. Kulkarni, Priyanka Rajendra. INTRACELLULAR UNBOUND CONCENTRATIONS OF ATORVASTATIN AND BOSENTAN: PREDICTION USING MODELING AND SIMULATION, AND EFFECT OF METABOLISM AND TRANSPORT.

Degree: PhD, 2017, Temple University

URL: http://digital.library.temple.edu/u?/p245801coll10,435930

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Pharmaceutical Sciences

Accurate prediction of target activity of a drug and rational design of dosing regimen requires knowledge of concentration-time course of the drug at… (more)

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Pharmaceutical Sciences

Accurate prediction of target activity of a drug and rational design of dosing regimen requires knowledge of concentration-time course of the drug at the target. In vitro in vivo correlation (IVIVC) successfully predicts activity and pharmacokinetics of some drugs but is unsuccessful with many others due to poor permeability, transporter activity and use of plasma drug concentrations for determination of PK parameters. According to the free drug hypothesis, at steady state, the unbound drug concentration on either side of a biomembrane is equal. In this case, unbound plasma drug concentration acts as a good surrogate for unbound cell concentrations. However, presence of transporters coupled with poor membrane permeability result in violation of the free drug hypothesis. This results in failure of IVIVC and subsequent discrepancies in the prediction of target activity of pharmacokinetic predictions. Since it is the unbound drug that is capable of exerting the pharmacodynamic effect and available for intracellular metabolizing and transport machinery, knowledge of the unbound concentration inside the cell is very important. Experimental measurement of intracellular unbound concentration is very difficult due to the small size of the cell and complex cellular disposition resulting from activity of metabolizing enzymes, transporters, target binding and organelle binding within the cell. The present study, therefore, aims at predicting the intracellular unbound concentrations using modeling and simulation approach. Liver perfusion experiments were conducted in male Sprague Dawley rats with uptake transporter substrates atorvastatin and bosentan, in presence and absence of inhibitors of active uptake and metabolism, to study tissue distribution of these drugs in presence of uptake transport and metabolism. The outflow perfusate data thus obtained were used as input for the explicit membrane model for liver to predict the unbound intracellular concentrations of atorvastatin and bosentan. Similarly, in vivo pharmacokinetic experiments were also conducted in rats in presence and absence of inhibitors of active uptake and metabolism. The data obtained were used as input for hybrid compartmental models to predict unbound concentrations of these drugs upon intravenous dosing. Modeling exercises were also conducted to study the differential impact of inhibition of active uptake on plasma versus unbound cell concentrations. The effect of uptake transport on the induction potential of bosentan was studied in sandwich cultured rat hepatocytes and in in vivo studies in rats. Inhibition of active uptake in the liver perfusion studies increased the outflow perfusate concentrations, decreased the amount recovered in the bile for atorvastatin and bosentan, and decreased the liver concentrations for atorvastatin. The liver concentrations for bosentan with inhibition of active uptake were not different than the control group. Inhibition of active uptake in the in vivo studies also decreased the systemic clearance…

Advisors/Committee Members: Nagar, Swati V.;, Korzekwa, Kenneth, Wong, Ho-Lun, Tweedie, Donald;.

Subjects/Keywords: Pharmaceutical sciences

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APA (6^th Edition):

Kulkarni, P. R. (2017). INTRACELLULAR UNBOUND CONCENTRATIONS OF ATORVASTATIN AND BOSENTAN: PREDICTION USING MODELING AND SIMULATION, AND EFFECT OF METABOLISM AND TRANSPORT. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,435930

Chicago Manual of Style (16^th Edition):

Kulkarni, Priyanka Rajendra. “INTRACELLULAR UNBOUND CONCENTRATIONS OF ATORVASTATIN AND BOSENTAN: PREDICTION USING MODELING AND SIMULATION, AND EFFECT OF METABOLISM AND TRANSPORT.” 2017. Doctoral Dissertation, Temple University. Accessed February 25, 2020. http://digital.library.temple.edu/u?/p245801coll10,435930.

MLA Handbook (7^th Edition):

Kulkarni, Priyanka Rajendra. “INTRACELLULAR UNBOUND CONCENTRATIONS OF ATORVASTATIN AND BOSENTAN: PREDICTION USING MODELING AND SIMULATION, AND EFFECT OF METABOLISM AND TRANSPORT.” 2017. Web. 25 Feb 2020.

Vancouver:

Kulkarni PR. INTRACELLULAR UNBOUND CONCENTRATIONS OF ATORVASTATIN AND BOSENTAN: PREDICTION USING MODELING AND SIMULATION, AND EFFECT OF METABOLISM AND TRANSPORT. [Internet] [Doctoral dissertation]. Temple University; 2017. [cited 2020 Feb 25]. Available from: http://digital.library.temple.edu/u?/p245801coll10,435930.

Council of Science Editors:

Kulkarni PR. INTRACELLULAR UNBOUND CONCENTRATIONS OF ATORVASTATIN AND BOSENTAN: PREDICTION USING MODELING AND SIMULATION, AND EFFECT OF METABOLISM AND TRANSPORT. [Doctoral Dissertation]. Temple University; 2017. Available from: http://digital.library.temple.edu/u?/p245801coll10,435930

7. P. SHASHIDHAR. DESIGN AND EVALUATION OF ORAL ANTIDIABETIC AGENTS AS BILAYERED TABLETS;.

Degree: 2013, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/10196

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The present work, an industrial project, entitled Formulation Development and Evaluation of metformin hydrochloride sustained release and glimepiride immediate release bilayered Tablet, taken up in… (more)

Subjects/Keywords: PHARMACEUTICAL SCIENCES

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APA (6^th Edition):

SHASHIDHAR, P. (2013). DESIGN AND EVALUATION OF ORAL ANTIDIABETIC AGENTS AS BILAYERED TABLETS;. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/10196

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

SHASHIDHAR, P.. “DESIGN AND EVALUATION OF ORAL ANTIDIABETIC AGENTS AS BILAYERED TABLETS;.” 2013. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed February 25, 2020. http://shodhganga.inflibnet.ac.in/handle/10603/10196.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

SHASHIDHAR, P.. “DESIGN AND EVALUATION OF ORAL ANTIDIABETIC AGENTS AS BILAYERED TABLETS;.” 2013. Web. 25 Feb 2020.

Vancouver:

SHASHIDHAR P. DESIGN AND EVALUATION OF ORAL ANTIDIABETIC AGENTS AS BILAYERED TABLETS;. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2013. [cited 2020 Feb 25]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/10196.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

SHASHIDHAR P. DESIGN AND EVALUATION OF ORAL ANTIDIABETIC AGENTS AS BILAYERED TABLETS;. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2013. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/10196

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Vasantharaju S G. Development of Thiazolidin 4 one Derivatives for possible Hypolipidaemic and Antidiabetic activities.

Degree: Pharmaceutical Sciences, 2011, Manipal University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/4970

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Twenty one thiazolidin-4-one derivatives were synthesized, purified by chromatographic and non-chromatographic methods. These were characterized through physical constants like melting point, various spectral and chromatographic… (more)

Subjects/Keywords: Pharmaceutical Sciences

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APA (6^th Edition):

G, V. S. (2011). Development of Thiazolidin 4 one Derivatives for possible Hypolipidaemic and Antidiabetic activities. (Thesis). Manipal University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/4970

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

G, Vasantharaju S. “Development of Thiazolidin 4 one Derivatives for possible Hypolipidaemic and Antidiabetic activities.” 2011. Thesis, Manipal University. Accessed February 25, 2020. http://shodhganga.inflibnet.ac.in/handle/10603/4970.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

G, Vasantharaju S. “Development of Thiazolidin 4 one Derivatives for possible Hypolipidaemic and Antidiabetic activities.” 2011. Web. 25 Feb 2020.

Vancouver:

G VS. Development of Thiazolidin 4 one Derivatives for possible Hypolipidaemic and Antidiabetic activities. [Internet] [Thesis]. Manipal University; 2011. [cited 2020 Feb 25]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/4970.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

G VS. Development of Thiazolidin 4 one Derivatives for possible Hypolipidaemic and Antidiabetic activities. [Thesis]. Manipal University; 2011. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/4970

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

9. Shanmugam, Ramesh Kumar. Lyophilized formulation development with novel excipients derived from cassia roxburghii for a pegylated therapeutic protein.

Degree: Pharmaceutical Sciences, 2013, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/13225

►

The principal of this thesis is newlineThe objective of the present research is to assess the use of a constituent of Cassia Roxburghii as a… (more)

Subjects/Keywords: Pharmaceutical Sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shanmugam, R. K. (2013). Lyophilized formulation development with novel excipients derived from cassia roxburghii for a pegylated therapeutic protein. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/13225

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shanmugam, Ramesh Kumar. “Lyophilized formulation development with novel excipients derived from cassia roxburghii for a pegylated therapeutic protein.” 2013. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed February 25, 2020. http://shodhganga.inflibnet.ac.in/handle/10603/13225.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shanmugam, Ramesh Kumar. “Lyophilized formulation development with novel excipients derived from cassia roxburghii for a pegylated therapeutic protein.” 2013. Web. 25 Feb 2020.

Vancouver:

Shanmugam RK. Lyophilized formulation development with novel excipients derived from cassia roxburghii for a pegylated therapeutic protein. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2013. [cited 2020 Feb 25]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/13225.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shanmugam RK. Lyophilized formulation development with novel excipients derived from cassia roxburghii for a pegylated therapeutic protein. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2013. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/13225

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

10. Vijapur, Laxman. Thiolated chitosans as potential carriers for selected api s targeted to git for enhanced mucoadhesion.

Degree: Pharmaceutical Sciences, 2013, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/13228

►

The phenomenon of mucoadhesion, however, is unpredictable due to varying turnover time and composition of mucus, different behavior of mucoadhesive devices over the pH range,… (more)

▼

The phenomenon of mucoadhesion, however, is unpredictable due to varying turnover time and composition of mucus, different behavior of mucoadhesive devices over the pH range, and disease conditions. The lack of specificity in adhering to specific mucous tissue seriously limits drug delivery/targeting through this technique, thus mucoadhesive polymers in many cases are not proven to be effective as pharmaceutical glue. Chitosan is a natural polycationic copolymer consisting of glucosamine and N-acetylglucosamine units. The polymer has valuable properties as a biomaterial because it is considered to be mucoadhesive, biocompatible, biodegradable and non-toxic. The objective of present study is to enhance the mucoadhesion of chitosan by thiolating chitosan with various thiolating agents which are capable of forming covalent disulfide bonds between thiomers and cysteine-rich subdomains of mucus glycoproteins and enhance mucoadhesion of tablet. The derivatizations of the primary amino groups of chitosan with thiolating agents like Thioglycolic acid and L-Cysteine leads to the formation of thiolated chitosan where the reaction was mediated by EDAC. To evaluate the mucoadhesive property of thiolated chitosan, methotrexate and cefuroxime axetil was chosen as model drug. Mucoadhesive tablets of thiolated chitosan were prepared by direct compression method and prepared formulations were subjected to evaluations like in vitro adhesion, water uptake studies, in vitro drug release studies and in vivo residence studies. In vitro dissolution studies of thiolated chitosan tablet indicated non-Fickian diffusion controlled drug release mechanism and was best fitted into Korsmeyer Peppas equation. In vitro mucoadhesion was up to 48.13 ± 0.31 hours for MTXF6 formulation and 48.38 ± 0.04 for CF6 where as In vivo radiographic studies conducted in rabbits for optimized formulation indicated over 36 hours retention of tablet in the stomach region for MTXF6 formulation. Hence from the above result we found that thiolated chitosan has enhanced mucoadhes

References

Advisors/Committee Members: Sreenivas S A.

Subjects/Keywords: Pharmaceutical Sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vijapur, L. (2013). Thiolated chitosans as potential carriers for selected api s targeted to git for enhanced mucoadhesion. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/13228

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vijapur, Laxman. “Thiolated chitosans as potential carriers for selected api s targeted to git for enhanced mucoadhesion.” 2013. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed February 25, 2020. http://shodhganga.inflibnet.ac.in/handle/10603/13228.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vijapur, Laxman. “Thiolated chitosans as potential carriers for selected api s targeted to git for enhanced mucoadhesion.” 2013. Web. 25 Feb 2020.

Vancouver:

Vijapur L. Thiolated chitosans as potential carriers for selected api s targeted to git for enhanced mucoadhesion. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2013. [cited 2020 Feb 25]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/13228.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vijapur L. Thiolated chitosans as potential carriers for selected api s targeted to git for enhanced mucoadhesion. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2013. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/13228

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

11. Shinde, Prashant Vishwas. Formulation and development of Pulsatile drug delivery systems PDDS.

Degree: Pharmaceutical sciences, 2013, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/13229

►

The principal of this thesis is newlineNow a day there is increase interest in academics as well as industrial research groups in novel dosage forms… (more)

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The principal of this thesis is newlineNow a day there is increase interest in academics as well as industrial research groups in novel dosage forms that can be retained in the stomach for a prolonged and predictable period of time. newlinePulsatile drug delivery systems are gaining a lot of interest now days. These systems are designed according to the circadian rhythm of the body. These systems deliver the drug at specific time as per the pathophysiological need of the disease, resulting in improved patient compliance and therapeutic efficacy. Which is meant as the liberation of drugs following programmed lag phases, has drawn increasing interest, especially in view of emerging chronotherapeutic approaches. Pulsatile drug delivery shows rhythms like rheumatoid arthritis, cardiovascular diseases, asthma, peptic ulcer, allergic rhinitis. newlineAceclofenac, a nonsteroidal anti-inflammatory drug, is used for the symptomatic relief of pain and joint stiffness in patients suffering from rheumatoid arthritis, which is characterized by diurnal variation in circulating levels of proinflammatory cytokines, interleukin-6 and/or tumor necrosis factor-and#945;. Due to this diurnal variation, many symptoms and signs of active rheumatoid arthritis are manifested in the morning.7 on oral administration at bed-time, releases Aceclofenac after a desired lag time of about 360 - 420 minutes which corresponds with peak levels of proinflammatory mediators. newlineThe objective of this work was to develop current study illustrates the formulation, characterization, and optimization of press coated tablet,. floating-pulsatile drug delivery system and Formulation development of coated tablet of Aceclofenac by using coating of rupturable layer. Press-coating, also known as compression coating, is relatively simple and cheap, and may involve direct compression of both the core and the coat, obviating the need for a separate coating process and the use of coating solutions. Materials such as hydrophilic cellulose derivatives can be used newline newline

References

Advisors/Committee Members: Mayee, Rahul V.

Subjects/Keywords: Pharmaceutical sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shinde, P. V. (2013). Formulation and development of Pulsatile drug delivery systems PDDS. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/13229

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shinde, Prashant Vishwas. “Formulation and development of Pulsatile drug delivery systems PDDS.” 2013. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed February 25, 2020. http://shodhganga.inflibnet.ac.in/handle/10603/13229.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shinde, Prashant Vishwas. “Formulation and development of Pulsatile drug delivery systems PDDS.” 2013. Web. 25 Feb 2020.

Vancouver:

Shinde PV. Formulation and development of Pulsatile drug delivery systems PDDS. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2013. [cited 2020 Feb 25]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/13229.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shinde PV. Formulation and development of Pulsatile drug delivery systems PDDS. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2013. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/13229

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. Desai Sanjeevani Rajaram. Development of Surfactant Based Novel Topical Formulation for Antifungal Therapy;.

Degree: 2014, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/15202

►

Skin is an extensively act as route of administration for local and systemic API application and is potentially a route for their delivery as non… (more)

▼

Skin is an extensively act as route of administration for local and systemic API application and is potentially a route for their delivery as non ionic surfactant vesicle. Drug delivery by topical route is effective only by better skin penetration to the required layer of skin. Dermatophyte causes the fungal infection, in which dermatophyte infect top layer of skin. Patient suffering from cutaneous candidiasis cure with combined formulation of nystatin and triamcinolone acetonie reveal prominent healing of erythema and pruritis than therapy of nystatin and triamcinolone acetonide alone. newlineTopical conventional formulations have limitation like penetration through barrier layer of skin. Barrier layer hampers deposition of active pharmaceutical ingredient. Therefore it is essential to select proper carrier by taking in to consideration that selected carrier enhance deposition of API (active pharmaceutical ingredient) by means of topical medicament. Topical applicability of niosomes was further enhanced by developing niosomal gel formulation using carbomers. In our present research work, we have incorporated drug into niosome by using Ether injection method by applying 32 factorial designs. The niosomes were characterized for poly-dispersibility index, entrapment power, vesicle charge determination, API release study. Niosomal dispersion showed sustained released but further topical applicability of the developed formulation was enhanced by development of gel formulation. Stable niosomal gel was evaluated for the various parameters like drug content, pH, spredability, viscosity, microscopic evaluation. The stability, Safety and efficacy studies of the developed gel were carried out.Extensive research study showed that the developed niogel formulation has shown great potential in the topical antifungal therapy by giving a extended release profile. Therefore safe, efficacious, non irritant surfactant based topical formulation was successfully developed for treatment of fungal disease. newline newline

Advisors/Committee Members: Disouza John Intru.

Subjects/Keywords: Pharmaceutical Sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rajaram, D. S. (2014). Development of Surfactant Based Novel Topical Formulation for Antifungal Therapy;. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/15202

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rajaram, Desai Sanjeevani. “Development of Surfactant Based Novel Topical Formulation for Antifungal Therapy;.” 2014. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed February 25, 2020. http://shodhganga.inflibnet.ac.in/handle/10603/15202.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rajaram, Desai Sanjeevani. “Development of Surfactant Based Novel Topical Formulation for Antifungal Therapy;.” 2014. Web. 25 Feb 2020.

Vancouver:

Rajaram DS. Development of Surfactant Based Novel Topical Formulation for Antifungal Therapy;. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. [cited 2020 Feb 25]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15202.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rajaram DS. Development of Surfactant Based Novel Topical Formulation for Antifungal Therapy;. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15202

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. Chinmay Anand. Novel strategies in formulation development And evaluation of dispersible tablets;.

Degree: 2014, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/15220

►

The basic aim behind development of any drug delivery system (DDS) is to achieve a safe and effective therapy for the human being. The dispersible… (more)

▼

The basic aim behind development of any drug delivery system (DDS) is to achieve a safe and effective therapy for the human being. The dispersible tablet provides a utility dosage form, reducing the need for multiple formulations of the same drug. The novel concept of Rapid dispersible drug delivery system emerged from the desire to provide patient with conventional mean of taking their medication. In recent days major concentration for development work is laid down on the development of organoleptically elegant such as good in taste and patient friendly drug delivery system for the usage of pediatric and geriatric patients. The greater bioavailability of a drug from Rapid dispersible and or dissolving formulations also make it preferable dose as compare to conventional oral dosage forms. newline newlineThe main aim of this study is to develop new concept for the formulation of rapid dispersible tablets or Fast dissolving tablets using novel concepts such as solubility enhancement of active for fast and better release of drug to achieve better bioavailability of active in vivo, taste masking of active with various techniques to improve organoleptic properties and patience compliance. The design of formulation was basically developed for the pediatric and geriatric patients. Paracetamol and Tolfenamic Acid were used as model drugs in formulation study. The present study is an attempt towards application of some novel concepts in formulation of Rapid Dispersible Tablets. On the basis of preformulation study and characterization of active, development of rapid dispersible tablets of Tolfenamic acid initiated with concept of co-micronization with diluents requires. The rapid release of formulation was the basic behind the experimental study. Optimization of formulation parameters was completed to achieve the balance between various physical properties such as disintegration and dispersion time and analytical properties such as release profile of tablets. newline newline

Advisors/Committee Members: G. Vidyasagar.

Subjects/Keywords: Pharmaceutical Sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Anand, C. (2014). Novel strategies in formulation development And evaluation of dispersible tablets;. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/15220

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Anand, Chinmay. “Novel strategies in formulation development And evaluation of dispersible tablets;.” 2014. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed February 25, 2020. http://shodhganga.inflibnet.ac.in/handle/10603/15220.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Anand, Chinmay. “Novel strategies in formulation development And evaluation of dispersible tablets;.” 2014. Web. 25 Feb 2020.

Vancouver:

Anand C. Novel strategies in formulation development And evaluation of dispersible tablets;. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. [cited 2020 Feb 25]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15220.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Anand C. Novel strategies in formulation development And evaluation of dispersible tablets;. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15220

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. Bhagwat Durgacharan Arun. Self microemulsifying drug delivery system of cardiovascular drugs for enhanced bioavailability;.

Degree: 2014, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/15221

►

Aim of present investigation was to develop Solid self micro emulsifying drug delivery system (S-SMEDDS) of cardiovascular drugs such as Telmisartan (TEL) and Verapamil Hydrochloride… (more)

▼

Aim of present investigation was to develop Solid self micro emulsifying drug delivery system (S-SMEDDS) of cardiovascular drugs such as Telmisartan (TEL) and Verapamil Hydrochloride (VPH) to enhance solubility, dissolution rate which may improve therapeutic performance and drug loading capacity so as to develop alternative to traditional oral formulations to improve bioavailability. In this study Oleic acid, Tween 80 and PEG 400 were selected as oil, surfactant and co-surfactant respectively for TEL and Castor oil, Labrasol, Transcutol P were selected as oil, surfactant and co-surfactant respectively for VPH. The three formulations were selected from ternary phase diagram at Km value 3, named as TLM1, TLM2, and TLM3 for TEL and VLM1, VLM2 and VLM3 for VPH and prepared successfully. Prepared liquid SMEDDS were evaluated for different parameters. From this study it was found that all formulations of liquid SMEDDS showed globule size in nanometric range, good stability with no phase separation, creaming or cracking and rapidly formed micro emulsion which was clear and slightly bluish in appearance. All these formulations were converted into S-SMEDDS by spray drying and adsorption technique. For spray drying maltodextrin and HPMC K15M were used as solid carrier for TEL and VPH respectively and for adsorption technique Neusilin US2 and Aerosil 200 were used as solid carrier for TEL. Prepared S-SMEDDS were evaluated for micromeritic properties, various reconstitution properties and for in-vitro dissolution study. Formulations were optimized on the basis of drug content, in-vitro drug release, globule size, PDI, zeta potential of reconstituted S-SMEDDS, spray dried process yield, etc and selected formulations were further studied for solid state characterization, morphological analysis, ex-vivo intestinal permeability studies, bioavailability and stability study. Ex-vivo intestinal permeability study of TEL S-SMEDDS formulations concluded that, drug diffused through the biological membrane has more when it is given in

Advisors/Committee Members: Disouza John Intru.

Subjects/Keywords: Pharmaceutical Sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Arun, B. D. (2014). Self microemulsifying drug delivery system of cardiovascular drugs for enhanced bioavailability;. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/15221

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Arun, Bhagwat Durgacharan. “Self microemulsifying drug delivery system of cardiovascular drugs for enhanced bioavailability;.” 2014. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed February 25, 2020. http://shodhganga.inflibnet.ac.in/handle/10603/15221.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Arun, Bhagwat Durgacharan. “Self microemulsifying drug delivery system of cardiovascular drugs for enhanced bioavailability;.” 2014. Web. 25 Feb 2020.

Vancouver:

Arun BD. Self microemulsifying drug delivery system of cardiovascular drugs for enhanced bioavailability;. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. [cited 2020 Feb 25]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15221.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arun BD. Self microemulsifying drug delivery system of cardiovascular drugs for enhanced bioavailability;. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15221

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Rathi Sanjeshkumar Gotam. Extraction and evaluation of naturetic plants for anti fungal and anti bacterial activities;.

Degree: 2014, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/15222

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The world society depends on natural product on the bases of various reports. Thus Aim to investigate on six different natural product on four different… (more)

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The world society depends on natural product on the bases of various reports. Thus Aim to investigate on six different natural product on four different solvents for extraction Methanol, Water, Chloroform, n-Hexane were extracted through Soxhlet apparatus tested at various concentrations (100mg/ml, 50mg/ml, and 25mg/ml) against three bacterial strains such as Bacillus subtilis (121), Esc. coli (118), Staphylococcus epidermidis (3615) also tested against three fungal strains such as Candida glabreta (1632), Asper. flavus (871), and Candida albicans (183) used for antifungal and anti bacterial method for ZI and MIC against various microorganisms. A total 4 extract belonging to 6 plants were investigated. Among the plants tested, H. rosa sinensis, V. negundo L, S. lappa Costus showed best antibacterial and antifungal activity on methanol extracts according to Zone of inhbition. Thus according to the result compared with the standard drug it was discussed that the extracted on Methanol, Chloroform, n-Hexane and Water. The Methanol showed the good Zone of inhibition (mm) for the treatment at various bacterial and fungal diseases. It means that the methanol extract showed the highest percentage yield must be near to the potency to the standard drug range If Zee Zee 23mm-26mm and 17mm-20mm with a fungal strain of bacterial test organisms gainst.The screening for extraction and evaluation of naturetic plants for anti-fungal and anti-bacterial activities for Minimum inhibitory concentration (µg/ml). Among the six plants used four different solvents at antimicrobial strains for antibacterial and antifungal activity it showed the best on S. emarginatus, S. lappa Costus, on n-hexane extract according to Minimum inhibitory concentration leaf it showed satisfactory result against various bacteria and fungi on n-hexane extract showed the highest Minimum inhibitory concentration (µg/ml) 15-18 (and#956;g/ml) while minimum inhibitory concentration showed the lowest report then other remained crude extract Minimum Inhibitory concentrat

Advisors/Committee Members: Patel Kanubhai Rameshbhai.

Subjects/Keywords: Pharmaceutical Sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gotam, R. S. (2014). Extraction and evaluation of naturetic plants for anti fungal and anti bacterial activities;. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/15222

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gotam, Rathi Sanjeshkumar. “Extraction and evaluation of naturetic plants for anti fungal and anti bacterial activities;.” 2014. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed February 25, 2020. http://shodhganga.inflibnet.ac.in/handle/10603/15222.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gotam, Rathi Sanjeshkumar. “Extraction and evaluation of naturetic plants for anti fungal and anti bacterial activities;.” 2014. Web. 25 Feb 2020.

Vancouver:

Gotam RS. Extraction and evaluation of naturetic plants for anti fungal and anti bacterial activities;. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. [cited 2020 Feb 25]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15222.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gotam RS. Extraction and evaluation of naturetic plants for anti fungal and anti bacterial activities;. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15222

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

16. Ravikumar. Studies on borassus flabellifer fruit mucilage as versatile excipient for pharmaceutical formulations;.

Degree: 2014, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/15528

►

There are number of synthetic polymers are available in market for pharmaceutical formulations, but these synthetic polymers have certain disadvantages such as high cost, toxicity,… (more)

▼

There are number of synthetic polymers are available in market for pharmaceutical formulations, but these synthetic polymers have certain disadvantages such as high cost, toxicity, environmental pollution during synthesis,non-renewable sources,side effects, and poor patient compliance.Because of these disadvantages natural polymers such as natural gums and mucilage are preferred to semi synthetic and synthetic excipients because of the following advantages low cost and natural origin, free from side effects, biocompatible and bio-acceptable, renewable source, environmental friendly processing, local availability etc. Because of this demand for these substances are increasing and new sources are being developed. newlineThe endopserm of Borassus flabellifer fruit contains a high proportion of mucilage. Literature survey revealed that comprehensive physicochemical characterization and exploration of Borassus flabellifer fruit mucilage (BFM) as versatile pharmaceutical excipients in pharmaceutical formulations had not been done. Hence, the present study was aimed to enhance the use of BFM as a natural plant based excipients to develop various pharmaceutical formulations and it will encourage cultivation and use of this mucilage in the pharmaceutical industry. newlineThe disintegrating property of the BFM had been studied in comparison with commercially available superdisintegrant viz croscarmellose sodium in the formulation of Metformin HCl FDT s. The results indicated that the BFM exhibited better disintegrating property at lower concentration viz; 1%w/w than the crosscarmellose sodium, and hence it can be used as a superdisintegrant in the tablet formulations.The extracted BFM powder was evaluated for its binding properties in paracetamol compressed tablet. Its binding efficiency was compared with starch paste, which was used as standard binder at 10% w/v concentration. It can be observed from the results that tablets prepared using BFM at 8%w/v are comparable with tablets prepared using 10% w/v starch paste as standard binder.

Advisors/Committee Members: Rajarajeshwari N.

Subjects/Keywords: Pharmaceutical sciences

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APA (6^th Edition):

Ravikumar. (2014). Studies on borassus flabellifer fruit mucilage as versatile excipient for pharmaceutical formulations;. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/15528

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ravikumar. “Studies on borassus flabellifer fruit mucilage as versatile excipient for pharmaceutical formulations;.” 2014. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed February 25, 2020. http://shodhganga.inflibnet.ac.in/handle/10603/15528.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ravikumar. “Studies on borassus flabellifer fruit mucilage as versatile excipient for pharmaceutical formulations;.” 2014. Web. 25 Feb 2020.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

Ravikumar. Studies on borassus flabellifer fruit mucilage as versatile excipient for pharmaceutical formulations;. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. [cited 2020 Feb 25]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15528.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ravikumar. Studies on borassus flabellifer fruit mucilage as versatile excipient for pharmaceutical formulations;. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15528

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

17. Shaik.Md.Zakir Hussain. Novel functionalised polymer for nanoparticle formulaton with anti cancer drug;.

Degree: 2014, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/15530

►

The aim of this study was to investigate whether various polymers and drugs interacts in a specific manner and whether the nature of these interactions… (more)

▼

The aim of this study was to investigate whether various polymers and drugs interacts in a specific manner and whether the nature of these interactions I influences the physicochemical characteristic of the particles and their drug loading and release profile. By investigating drugs belonging to various classes and with different properties it has been possible to correlate properties associated with drug and pendent functional group of the polymer which are ultimately responsible for the drug loading and release characteristic. The chemistry and structure of poly (glycerol adipate) facilitate its substitution with various pendent functional groups leading to modification of the physicochemical properties of the polymer. Modified backbone then can be selected based upon the properties of the compound to be incorporated. Thus, this could be explored as a drug delivery system without many of the limitations of commercially available polymer. For some drug polymer formulations, good loading and controlled release rates have been achieved. Compared to various conventional polymer systems reported for nanoparticle formulations, poly (glycerol adipate) polymer have also demonstrated the ability to control rate of release of highly water soluble drugs, even from the most hydrophilic polymer backbone in its unsubustituted form. From the various drug loading and release profile it has been demonstrated that, unlike reported literature, particle size is not the primary factor influencing drug release over the relatively small range of particle size seen in this study. Neither is the water solubility of either the drug or the polymer alone responsible for the rapid and uncontrolled release profile from nanoparticles. Thus, Drug polymer interactions are more likely to influence drug loading and release and unlikely common reports in the literature, hydrophilicity, molecular weight or concentration of polymer / drug are less likely to affect these parameters in isolation. Recently, biodegradable polyesters such as poly

Advisors/Committee Members: G.VIDYA SAGAR.

Subjects/Keywords: Pharmaceutical sciences

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APA (6^th Edition):

Hussain, S. (2014). Novel functionalised polymer for nanoparticle formulaton with anti cancer drug;. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/15530

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hussain, Shaik.Md.Zakir. “Novel functionalised polymer for nanoparticle formulaton with anti cancer drug;.” 2014. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed February 25, 2020. http://shodhganga.inflibnet.ac.in/handle/10603/15530.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hussain, Shaik.Md.Zakir. “Novel functionalised polymer for nanoparticle formulaton with anti cancer drug;.” 2014. Web. 25 Feb 2020.

Vancouver:

Hussain S. Novel functionalised polymer for nanoparticle formulaton with anti cancer drug;. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. [cited 2020 Feb 25]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15530.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hussain S. Novel functionalised polymer for nanoparticle formulaton with anti cancer drug;. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15530

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

18. Chemansaheb Meerasaheb Jamkhandi. Synthesis and screening of newer benzotriazole derivatives for their antibacterial and antioxidant potential;.

Degree: 2014, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/16119

►

The objective of the present study was to evaluate antioxidant, antibacterial activity of a series of Benzotriazole Substituted with N-Phenylacetamide (Ia to Va), acetylcarbamic acid… (more)

Subjects/Keywords: Pharmaceutical Sciences

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APA (6^th Edition):

Jamkhandi, C. M. (2014). Synthesis and screening of newer benzotriazole derivatives for their antibacterial and antioxidant potential;. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/16119

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jamkhandi, Chemansaheb Meerasaheb. “Synthesis and screening of newer benzotriazole derivatives for their antibacterial and antioxidant potential;.” 2014. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed February 25, 2020. http://shodhganga.inflibnet.ac.in/handle/10603/16119.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jamkhandi, Chemansaheb Meerasaheb. “Synthesis and screening of newer benzotriazole derivatives for their antibacterial and antioxidant potential;.” 2014. Web. 25 Feb 2020.

Vancouver:

Jamkhandi CM. Synthesis and screening of newer benzotriazole derivatives for their antibacterial and antioxidant potential;. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. [cited 2020 Feb 25]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/16119.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jamkhandi CM. Synthesis and screening of newer benzotriazole derivatives for their antibacterial and antioxidant potential;. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/16119

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. K.PAVAN KUMAR. ANTIDIABETIC AND ANTICONVULSANT ACTIVITY OF SOME MEDICINAL PLANTS;.

Degree: 2013, Shri Jagdishprasad Jhabarmal Tibarewala University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/10292

►

The present study reveals antidiabetic activity of Madhuca indica and anticonvulsant activity of Vitex negundo. Screening of antidiabetic activity was carried against streptozotocin and streptozotocin-nicotinamide… (more)

Subjects/Keywords: PHARMACEUTICAL SCIENCES

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APA (6^th Edition):

KUMAR, K. (2013). ANTIDIABETIC AND ANTICONVULSANT ACTIVITY OF SOME MEDICINAL PLANTS;. (Thesis). Shri Jagdishprasad Jhabarmal Tibarewala University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/10292

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

KUMAR, K.PAVAN. “ANTIDIABETIC AND ANTICONVULSANT ACTIVITY OF SOME MEDICINAL PLANTS;.” 2013. Thesis, Shri Jagdishprasad Jhabarmal Tibarewala University. Accessed February 25, 2020. http://shodhganga.inflibnet.ac.in/handle/10603/10292.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

KUMAR, K.PAVAN. “ANTIDIABETIC AND ANTICONVULSANT ACTIVITY OF SOME MEDICINAL PLANTS;.” 2013. Web. 25 Feb 2020.

Vancouver:

KUMAR K. ANTIDIABETIC AND ANTICONVULSANT ACTIVITY OF SOME MEDICINAL PLANTS;. [Internet] [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2013. [cited 2020 Feb 25]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/10292.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

KUMAR K. ANTIDIABETIC AND ANTICONVULSANT ACTIVITY OF SOME MEDICINAL PLANTS;. [Thesis]. Shri Jagdishprasad Jhabarmal Tibarewala University; 2013. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/10292

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Kansas

20. Park, Jihea. Effect of pH, sucrose and mannitol on structure and long-term stability of a model IgG1 antibody upon freeze-drying.

Degree: MS, Pharmaceutical Chemistry, 2011, University of Kansas

URL: http://hdl.handle.net/1808/7632

► Purpose: The purpose of this study is to investigate the effect of pH and potential stabilizers on structure and long-term stability of an IgG1 monoclonal… (more)

▼ Purpose: The purpose of this study is to investigate the effect of pH and potential stabilizers on structure and long-term stability of an IgG1 monoclonal antibody in the solid state after freeze-drying. The inter-relationships between preservation of secondary and tertiary structure of the protein in the solid state and long term storage stability under different formulation conditions and temperatures was obtained from examining data collected using spectroscopic techniques and stability-indicating assays, respectively. Methods: Anti-Streptavidin IgG1 antibody was formulated with mannitol at pH 3.0, 5.0 and 7.0 in the presence and absence of sucrose as a stabilizer. All samples were stored at 4 ºC, 25 ºC, and 37 ºC up to 12 months and at 50 ºC for 6 months. Physical degradation of each lyophilized formulation was monitored using size-exclusion chromatography (SEC), covalent degradation was monitored using cation-exchange chromatography (CEX), and sub-visible particle counts (SbVP) were measured by HIAC. The secondary structure of the protein in the solid state was characterized using Fourier transform infrared (FTIR) spectroscopy and tertiary structure was monitored using fluorescence spectroscopy. Raman spectroscopy was also used to determine changes in secondary and tertiary structure spectral features. Results: The IgG1 antibody underwent significant secondary structural perturbations at pH 3.0 regardless of excipients, and all formulations without sucrose also showed decreased structural stability in the solid state. Based on observation of structural changes, formulation at pH 5.0, showed the least change over time and at elevated temperatures. This correlated with long-term stability upon reconstitution with respect to protein aggregate formation and sub-visible particle counts. Conclusions: The results of the study show that protein secondary and tertiary structural preservation in the solid state correlates to improved long-term stability of the monoclonal antibody in the different lyophilized formulations. Advisors/Committee Members: Laurence, Jennifer S. (advisor), Krishnan, Sampath (advisor), Volkin, David B. (cmtemember).

Subjects/Keywords: Pharmaceutical sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Park, J. (2011). Effect of pH, sucrose and mannitol on structure and long-term stability of a model IgG1 antibody upon freeze-drying. (Masters Thesis). University of Kansas. Retrieved from http://hdl.handle.net/1808/7632

Chicago Manual of Style (16^th Edition):

Park, Jihea. “Effect of pH, sucrose and mannitol on structure and long-term stability of a model IgG1 antibody upon freeze-drying.” 2011. Masters Thesis, University of Kansas. Accessed February 25, 2020. http://hdl.handle.net/1808/7632.

MLA Handbook (7^th Edition):

Park, Jihea. “Effect of pH, sucrose and mannitol on structure and long-term stability of a model IgG1 antibody upon freeze-drying.” 2011. Web. 25 Feb 2020.

Vancouver:

Park J. Effect of pH, sucrose and mannitol on structure and long-term stability of a model IgG1 antibody upon freeze-drying. [Internet] [Masters thesis]. University of Kansas; 2011. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/1808/7632.

Council of Science Editors:

Park J. Effect of pH, sucrose and mannitol on structure and long-term stability of a model IgG1 antibody upon freeze-drying. [Masters Thesis]. University of Kansas; 2011. Available from: http://hdl.handle.net/1808/7632

University of Kansas

21. Badawi, Ahmed H. Development of Peptides to Target Antigen Presenting Cells for Controlling the Immune Response in Experimental Autoimmune Encephalomyelitis.

Degree: PhD, Pharmaceutical Chemistry, 2011, University of Kansas

URL: http://hdl.handle.net/1808/9736

► Experimental autoimmune encephalomyelitis (EAE) is an animal model for the human disease multiple sclerosis (MS). In EAE and MS, the immune system recognizes proteins of… (more)

▼ Experimental autoimmune encephalomyelitis (EAE) is an animal model for the human disease multiple sclerosis (MS). In EAE and MS, the immune system recognizes proteins of the myelin sheath as antigenic, and an inflammatory reaction is initiated within the central nervous system (CNS), leading to demyelination of the axons. Current therapies for the treatment of MS are generally non-specific and weaken the global immune system, thus making the individual susceptible to opportunistic infections. The objective of this project is to develop peptides that target myelin-specific antigen presenting cells (APC) in order to modulate the immune response towards the myelin sheath. Bifunctional peptide inhibitors (BPI) are molecules composed of an antigenic peptide and an adhesion peptide that are designed to target the major histocompatibility class-II molecule and adhesion receptors, respectively, on the surface of APC. The simultaneous binding to both receptors on the APC is proposed to hinder the delivery of activation signals to T cells and, therefore, attenuate the inflammatory T cell response. In this study, PLP-BPI, a well-studied BPI molecule, was tested as a peptide vaccine in preventing the onset of EAE as well as for its role in providing protection against blood-brain barrier breakdown during disease. Next, a novel BPI molecule known as PLP-B7AP, which targets costimulatory molecules, was developed and tested for the first time in suppressing EAE. Finally, to provide protection against the diverse pool of antigenic proteins of the myelin sheath, BPI molecules targeting other myelin antigens as well as a multivalent BPI molecule were developed. These novel peptides have consistently demonstrated a shift towards an immuno-tolerant state accompanied by significant suppression of EAE. Advisors/Committee Members: Siahaan, Teruna J. (advisor), Berkland, Cory J. (cmtemember), Krise, Jeffrey P. (cmtemember), Volkin, David B. (cmtemember), Kuczera, Krzysztof (cmtemember).

Subjects/Keywords: Pharmaceutical sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Badawi, A. H. (2011). Development of Peptides to Target Antigen Presenting Cells for Controlling the Immune Response in Experimental Autoimmune Encephalomyelitis. (Doctoral Dissertation). University of Kansas. Retrieved from http://hdl.handle.net/1808/9736

Chicago Manual of Style (16^th Edition):

Badawi, Ahmed H. “Development of Peptides to Target Antigen Presenting Cells for Controlling the Immune Response in Experimental Autoimmune Encephalomyelitis.” 2011. Doctoral Dissertation, University of Kansas. Accessed February 25, 2020. http://hdl.handle.net/1808/9736.

MLA Handbook (7^th Edition):

Badawi, Ahmed H. “Development of Peptides to Target Antigen Presenting Cells for Controlling the Immune Response in Experimental Autoimmune Encephalomyelitis.” 2011. Web. 25 Feb 2020.

Vancouver:

Badawi AH. Development of Peptides to Target Antigen Presenting Cells for Controlling the Immune Response in Experimental Autoimmune Encephalomyelitis. [Internet] [Doctoral dissertation]. University of Kansas; 2011. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/1808/9736.

Council of Science Editors:

Badawi AH. Development of Peptides to Target Antigen Presenting Cells for Controlling the Immune Response in Experimental Autoimmune Encephalomyelitis. [Doctoral Dissertation]. University of Kansas; 2011. Available from: http://hdl.handle.net/1808/9736

University of Kansas

22. Behymer, Matthew Mark. Inhibition of Cell Adhesion by Peptides Derived from the EC-4 Domain of E-Cadherin.

Degree: MS, Pharmaceutical Chemistry, 2015, University of Kansas

URL: http://hdl.handle.net/1808/21666

► The objective of this project was to evaluate the biological activity of peptides derived from the EC-4 domain of E-cadherin in inhibiting E-cadherin-mediated cell-cell adhesion.… (more)

Subjects/Keywords: Pharmaceutical sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Behymer, M. M. (2015). Inhibition of Cell Adhesion by Peptides Derived from the EC-4 Domain of E-Cadherin. (Masters Thesis). University of Kansas. Retrieved from http://hdl.handle.net/1808/21666

Chicago Manual of Style (16^th Edition):

Behymer, Matthew Mark. “Inhibition of Cell Adhesion by Peptides Derived from the EC-4 Domain of E-Cadherin.” 2015. Masters Thesis, University of Kansas. Accessed February 25, 2020. http://hdl.handle.net/1808/21666.

MLA Handbook (7^th Edition):

Behymer, Matthew Mark. “Inhibition of Cell Adhesion by Peptides Derived from the EC-4 Domain of E-Cadherin.” 2015. Web. 25 Feb 2020.

Vancouver:

Behymer MM. Inhibition of Cell Adhesion by Peptides Derived from the EC-4 Domain of E-Cadherin. [Internet] [Masters thesis]. University of Kansas; 2015. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/1808/21666.

Council of Science Editors:

Behymer MM. Inhibition of Cell Adhesion by Peptides Derived from the EC-4 Domain of E-Cadherin. [Masters Thesis]. University of Kansas; 2015. Available from: http://hdl.handle.net/1808/21666

University of Kansas

23. Alabdulkarim, Abdullah. CONSENSUS GII.4 VIRUS LIKE PARTICLES; A VACCINE CANDIDATE BIOPHYSICAL CHARACTERIZATION, STABILIZATION, AND ADJUVANTS BINDING STUDIES.

Degree: MS, Pharmaceutical Chemistry, 2015, University of Kansas

URL: http://hdl.handle.net/1808/21659

► The World Health Organization (WHO) and the United Nations Children's Fund (UNICEF) estimate globally that 1.9 million children under the age of five years old… (more)

▼ The World Health Organization (WHO) and the United Nations Children's Fund (UNICEF) estimate globally that 1.9 million children under the age of five years old die annually as consequence of diarrhea. Increasing need for hospitalization, which has negative effects on health care sectors, in addition to mortality incidences mark diarrheal related diseases a growing burden on both health care sectors and the global economy. Introducing novel measures to control and avert the spread of diarrheal disease are of paramount importance. Diarrhea is the main symptom in Acute gastroenteritis (AGE) and according to the United States' National Outbreak Reporting System (NORS), viral agents are the dominant precursors of epidemic AGE outbreaks. More than 90% of humans' acute non-bacterial gastroenteritis breakouts worldwide is caused by Noroviruses (NoVs). NoVs of the Caliciviridae family are none enveloped, positive sense, single stranded RNA virus, noncultivable in cell culture, containing three open reading frames (ORF). Expressing NoVs ORF2 in a baculovirus expression system produces empty virus-like particles (VLPs). These VLPs are very similar to the native virus in terms of morphology and antigenicity, yet lacking the genetic material essential for infectivity, making the VLPs a superb candidate for vaccine development. By comparing the capsid sequence of three different NoVs GII.4 strains, consensus GII.4 VLPs were produced as a potential vaccine with the goal of providing a broader protection against AGE. The main objective of this study is to understand the structural behavior of NoVs Consensus GII.4 VLPs, which is to be used as a vaccine. A complement of biophysical techniques has been employed to characterize the physical stability of Noroviruses Consensus GII.4 virus-like particles (VLPs) as a function of temperature and pH. The VLPs' physical stability are characterized by different spectroscopic techniques and the resulting data are used to construct empirical phase diagrams (EPDs) projecting the entire data set in the form of a colored image. These EPDs are used in the development of excipient screening assays to identify potential stabilizers of the VLPs in solution. The identified stabilizers are then subjected to further screening using fluorescence analysis to determine their optimal concentrations and use in combination. The generated data are used to construct binding isotherms for Consensus GII.4 VLP and aluminum salt adjuvants (Alhydrogel® and Adjuphos®). Binding isotherms were also generated for Norwalk VLP (a previously studied vaccine candidate) and aluminum salt adjuvants. Front Face Fluorescence Spectroscopy is used to evaluate the structural changes associated with Consensus GII.4 and Norwalk VLPs when bound to aluminum salt adjuvants. Advisors/Committee Members: Middaugh, Charles R (advisor), Volkin, David B (cmtemember), Berkland, Cory J (cmtemember).

Subjects/Keywords: Pharmaceutical sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Alabdulkarim, A. (2015). CONSENSUS GII.4 VIRUS LIKE PARTICLES; A VACCINE CANDIDATE BIOPHYSICAL CHARACTERIZATION, STABILIZATION, AND ADJUVANTS BINDING STUDIES. (Masters Thesis). University of Kansas. Retrieved from http://hdl.handle.net/1808/21659

Chicago Manual of Style (16^th Edition):

Alabdulkarim, Abdullah. “CONSENSUS GII.4 VIRUS LIKE PARTICLES; A VACCINE CANDIDATE BIOPHYSICAL CHARACTERIZATION, STABILIZATION, AND ADJUVANTS BINDING STUDIES.” 2015. Masters Thesis, University of Kansas. Accessed February 25, 2020. http://hdl.handle.net/1808/21659.

MLA Handbook (7^th Edition):

Alabdulkarim, Abdullah. “CONSENSUS GII.4 VIRUS LIKE PARTICLES; A VACCINE CANDIDATE BIOPHYSICAL CHARACTERIZATION, STABILIZATION, AND ADJUVANTS BINDING STUDIES.” 2015. Web. 25 Feb 2020.

Vancouver:

Alabdulkarim A. CONSENSUS GII.4 VIRUS LIKE PARTICLES; A VACCINE CANDIDATE BIOPHYSICAL CHARACTERIZATION, STABILIZATION, AND ADJUVANTS BINDING STUDIES. [Internet] [Masters thesis]. University of Kansas; 2015. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/1808/21659.

Council of Science Editors:

Alabdulkarim A. CONSENSUS GII.4 VIRUS LIKE PARTICLES; A VACCINE CANDIDATE BIOPHYSICAL CHARACTERIZATION, STABILIZATION, AND ADJUVANTS BINDING STUDIES. [Masters Thesis]. University of Kansas; 2015. Available from: http://hdl.handle.net/1808/21659

University of Kansas

24. Farokhi, Elinaz. Determination of Binding Sites of Cadherin Peptides on the EC1 domain of E-cadherin using NMR Spectroscopy.

Degree: MS, Pharmaceutical Chemistry, 2014, University of Kansas

URL: http://hdl.handle.net/1808/21641

► The objective of this work is to evaluate the binding mechanisms of synthetic cadherin peptides (ADTC7, ADTC9 and cHAVc3) to the EC1 domain of human… (more)

Subjects/Keywords: Pharmaceutical sciences

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APA (6^th Edition):

Farokhi, E. (2014). Determination of Binding Sites of Cadherin Peptides on the EC1 domain of E-cadherin using NMR Spectroscopy. (Masters Thesis). University of Kansas. Retrieved from http://hdl.handle.net/1808/21641

Chicago Manual of Style (16^th Edition):

Farokhi, Elinaz. “Determination of Binding Sites of Cadherin Peptides on the EC1 domain of E-cadherin using NMR Spectroscopy.” 2014. Masters Thesis, University of Kansas. Accessed February 25, 2020. http://hdl.handle.net/1808/21641.

MLA Handbook (7^th Edition):

Farokhi, Elinaz. “Determination of Binding Sites of Cadherin Peptides on the EC1 domain of E-cadherin using NMR Spectroscopy.” 2014. Web. 25 Feb 2020.

Vancouver:

Farokhi E. Determination of Binding Sites of Cadherin Peptides on the EC1 domain of E-cadherin using NMR Spectroscopy. [Internet] [Masters thesis]. University of Kansas; 2014. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/1808/21641.

Council of Science Editors:

Farokhi E. Determination of Binding Sites of Cadherin Peptides on the EC1 domain of E-cadherin using NMR Spectroscopy. [Masters Thesis]. University of Kansas; 2014. Available from: http://hdl.handle.net/1808/21641

University of Kansas

25. Hutchison, Kevin Michael. Role of Glycosylation of IL-1ra on its Binding to IL-1R1.

Degree: MS, Pharmaceutical Chemistry, 2015, University of Kansas

URL: http://hdl.handle.net/1808/21664

► Interleukin 1 (IL-1) is an inflammatory cytokine that helps the immune system fight disease. The inflammatory action of IL-1 is regulated by the naturally occurring… (more)

Subjects/Keywords: Pharmaceutical sciences

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APA (6^th Edition):

Hutchison, K. M. (2015). Role of Glycosylation of IL-1ra on its Binding to IL-1R1. (Masters Thesis). University of Kansas. Retrieved from http://hdl.handle.net/1808/21664

Chicago Manual of Style (16^th Edition):

Hutchison, Kevin Michael. “Role of Glycosylation of IL-1ra on its Binding to IL-1R1.” 2015. Masters Thesis, University of Kansas. Accessed February 25, 2020. http://hdl.handle.net/1808/21664.

MLA Handbook (7^th Edition):

Hutchison, Kevin Michael. “Role of Glycosylation of IL-1ra on its Binding to IL-1R1.” 2015. Web. 25 Feb 2020.

Vancouver:

Hutchison KM. Role of Glycosylation of IL-1ra on its Binding to IL-1R1. [Internet] [Masters thesis]. University of Kansas; 2015. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/1808/21664.

Council of Science Editors:

Hutchison KM. Role of Glycosylation of IL-1ra on its Binding to IL-1R1. [Masters Thesis]. University of Kansas; 2015. Available from: http://hdl.handle.net/1808/21664

26. Pinto, Colin Andrew. Development and Characterization of Chitosan Crosslinked with Tripolyphosphate as a Sustained Release Agent in Tablets.

Degree: 2018, University of the Sciences in Philadelphia

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=10692987

► The ability of chitosan and tripolyphosphate to form an ionic crosslinked material and its effectiveness in sustained release formulations has been reported. However, key… (more)

▼ The ability of chitosan and tripolyphosphate to form an ionic crosslinked material and its effectiveness in sustained release formulations has been reported. However, key issues commonly observed with these formulations include inefficiencies and inaccuracies in the drug loading as well as an inability to achieve complete release of drug. Acetaminophen, as a model drug, was added to various chitosan-tripolyphosphate crosslinked powders to assess the sustained release characteristics when drug is added extragranularly as opposed to during the crosslinking process, which is the most common procedure for drug addition in prior literature. The influence of various process and formulation variables including chitosan concentration, chitosan:tripolyphosphate ratio, temperature, ionic strength, and pH was assessed. Design of experiments allowed the identification of factors and two factor interactions that have significant effects on particle size and size distribution, yield, zeta potential, true density, and drug release. Statistical model equations were successfully used to manufacture optimized chitosan-tripolyphosphate crosslinked powders with various properties for further evaluation. Analysis of the compressibility of the optimized powders revealed that the crosslinked powders had enhanced compression properties when compared to chitosan powder. Environmental scanning electron microscopy revealed a correlation between the rigidity and density of the powders and corresponding capabilities for enhanced sustained release. Analysis of the moisture sorption and desorption isotherms from dynamic vapor sorption analysis revealed various types and levels of water present and a correlation between the quantity of water internally absorbed during sorption and desorption and sustained release capability. Chitosan-tripolyphosphate crosslinked powder can be manufactured with optimized properties that allow desired sustained drug release profiles while simultaneously serving as the primary diluent for solid oral dosage forms.

Subjects/Keywords: Pharmaceutical sciences

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pinto, C. A. (2018). Development and Characterization of Chitosan Crosslinked with Tripolyphosphate as a Sustained Release Agent in Tablets. (Thesis). University of the Sciences in Philadelphia. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=10692987

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pinto, Colin Andrew. “Development and Characterization of Chitosan Crosslinked with Tripolyphosphate as a Sustained Release Agent in Tablets.” 2018. Thesis, University of the Sciences in Philadelphia. Accessed February 25, 2020. http://pqdtopen.proquest.com/#viewpdf?dispub=10692987.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pinto, Colin Andrew. “Development and Characterization of Chitosan Crosslinked with Tripolyphosphate as a Sustained Release Agent in Tablets.” 2018. Web. 25 Feb 2020.

Vancouver:

Pinto CA. Development and Characterization of Chitosan Crosslinked with Tripolyphosphate as a Sustained Release Agent in Tablets. [Internet] [Thesis]. University of the Sciences in Philadelphia; 2018. [cited 2020 Feb 25]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10692987.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pinto CA. Development and Characterization of Chitosan Crosslinked with Tripolyphosphate as a Sustained Release Agent in Tablets. [Thesis]. University of the Sciences in Philadelphia; 2018. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10692987

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

27. Abhyankar, Hrishita. Stabilization of the Amorphous Form of Poorly Soluble Drugs Using Ethyl Cellulose in Solid Dispersions.

Degree: 2018, University of the Sciences in Philadelphia

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=10692990

► The aims of this research was to evaluate the partial crystallinity of two BCS class II drugs (Ketoconazole and Chlorpropamide) when prepared as solid-dispersions… (more)

Subjects/Keywords: Pharmaceutical sciences

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APA (6^th Edition):

Abhyankar, H. (2018). Stabilization of the Amorphous Form of Poorly Soluble Drugs Using Ethyl Cellulose in Solid Dispersions. (Thesis). University of the Sciences in Philadelphia. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=10692990

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Abhyankar, Hrishita. “Stabilization of the Amorphous Form of Poorly Soluble Drugs Using Ethyl Cellulose in Solid Dispersions.” 2018. Thesis, University of the Sciences in Philadelphia. Accessed February 25, 2020. http://pqdtopen.proquest.com/#viewpdf?dispub=10692990.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Abhyankar, Hrishita. “Stabilization of the Amorphous Form of Poorly Soluble Drugs Using Ethyl Cellulose in Solid Dispersions.” 2018. Web. 25 Feb 2020.

Vancouver:

Abhyankar H. Stabilization of the Amorphous Form of Poorly Soluble Drugs Using Ethyl Cellulose in Solid Dispersions. [Internet] [Thesis]. University of the Sciences in Philadelphia; 2018. [cited 2020 Feb 25]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10692990.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Abhyankar H. Stabilization of the Amorphous Form of Poorly Soluble Drugs Using Ethyl Cellulose in Solid Dispersions. [Thesis]. University of the Sciences in Philadelphia; 2018. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10692990

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Irvine

28. Liu, Shuai. Towards an automated computational pipeline to guide drug lead optimization.

Degree: Pharmacological Sciences with a concentration in Pharmaceutical Sciences Ph, 2015, University of California – Irvine

URL: http://www.escholarship.org/uc/item/6t03g54n

► Molecular dynamics (MD) simulations are a promising tool to guide drug lead optimization. But because these tools are applied prospectively in drug discovery, blind tests… (more)

▼ Molecular dynamics (MD) simulations are a promising tool to guide drug lead optimization. But because these tools are applied prospectively in drug discovery, blind tests provide a key opportunity to validate these for real-world applications. I participated in the Statistical Assessment of Modeling of Proteins and Ligands (SAMPL) 3 blind test (chapter 1) in which I used different force fields to calculate hydration free energies and SAMPL4 (chapter 2) in which I analyzed pose prediction results from different groups using different computational tools. The results from these blind tests improve our understanding of the accuracy of current methods, allowing us to improve these methods. Large-scale applications of MD simulations to drug discovery have been few, partly because of the difficulty of planning and setting up the simulations. For example, alchemical relative free energy (RFE) calculations have relatively high accuracy in predicting differences in binding between drug lead compounds and new derivatives which are sought to improve binding potency. But setting up RFE calculations for large sets of compounds has required far too much manual intervention to be practical. I helped develop an algorithm, LOMAP (chapter3), to automatically plan and set up these calculations. Resulting applications indicated that it could successfully reduce the time of planning RFE calculations. But in this project, we assumed that relative free energy (RFE) calculations involving ring breaking will introduce substantial error, and we tried to avoid these calculations as much as possible. Later, we quantitatively calculated what these errors would be to confirm this (chapter4). Beside binding free energy calculations, MD simulations can also be used to predict solubilities. We used free energy calculations (chapter5) to calculate relative solubilities and compared the results with experiment and with results from more empirical chemical engineering methods. We found that our approach is more accurate, despite its straightforward nature. Long-term, we are working towards developing an automated pipeline to help guide key aspects of drug lead optimization. My work helped with understanding the accuracy of current techniques, improving their automation, and providing a new technique for predicting physical properties like solubilities.

Subjects/Keywords: Pharmaceutical sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Liu, S. (2015). Towards an automated computational pipeline to guide drug lead optimization. (Thesis). University of California – Irvine. Retrieved from http://www.escholarship.org/uc/item/6t03g54n

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Liu, Shuai. “Towards an automated computational pipeline to guide drug lead optimization.” 2015. Thesis, University of California – Irvine. Accessed February 25, 2020. http://www.escholarship.org/uc/item/6t03g54n.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Liu, Shuai. “Towards an automated computational pipeline to guide drug lead optimization.” 2015. Web. 25 Feb 2020.

Vancouver:

Liu S. Towards an automated computational pipeline to guide drug lead optimization. [Internet] [Thesis]. University of California – Irvine; 2015. [cited 2020 Feb 25]. Available from: http://www.escholarship.org/uc/item/6t03g54n.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Liu S. Towards an automated computational pipeline to guide drug lead optimization. [Thesis]. University of California – Irvine; 2015. Available from: http://www.escholarship.org/uc/item/6t03g54n

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Minnesota

29. Mistry, Pinal. Strength of drug-polymer interactions: Implications on molecular mobility and crystallization in amorphous dispersions.

Degree: PhD, Pharmaceutics, 2016, University of Minnesota

URL: http://hdl.handle.net/11299/201501

► Amorphous solid dispersions (ASDs) provide a powerful avenue to potentially enhance the solubility of water-insoluble drugs. However, the physical instability in the amorphous state (i.e.… (more)

▼ Amorphous solid dispersions (ASDs) provide a powerful avenue to potentially enhance the solubility of water-insoluble drugs. However, the physical instability in the amorphous state (i.e. crystallization) is a major impediment to the development ASDs as solid oral dosage forms. By identifying the key factors affecting the stability and the underlying mechanism of stabilization by the polymer, robust solid dispersions can be formulated that are resistant to crystallization. The goal of this thesis work is to (i) gain a mechanistic understanding of the stabilization brought about by drug-polymer interactions, (ii) provide guidelines for rational selection of polymers and (iii) provide simple and rapid methods for predicting crystallization times in ASDs. Overall our objectives were (i) to study the role of the strength of drug-polymer interactions on the molecular mobility and crystallization propensity (both onset time and crystallization rate) of ASDs, (ii) to study the coupling between mobility and crystallization and thereby use molecular mobility as a predictor of crystallization times in ASDs and (iii) provide an accelerated stability screening approach to predict long-term stability of ASDs. In our model systems (ketoconazole ASDs), both an increase in strength of drug-polymer interactions as well as polymer concentration resulted in a disproportionate increase in relaxation times (lowering of the molecular mobility). Stronger drug-polymer interactions translated to longer crystallization onset times and a decrease in the magnitude of crystallization rate constant, indicating enhancement in physical stability. The extent of coupling between relaxation times and crystallization times was moderate (coupling coefficient ~ 0.5) and was unaffected by the strength of drug-polymer interactions. Using molecular mobility as a determinant, a prediction model was developed to estimate crystallization times in ASDs. The predicted and experimental values were in good agreement, indicating the usefulness of the model. Additionally, water sorption was used as an accelerated stability testing approach to rank order ASDs and predict the long-term stability in glassy state. Strong drug-polymer interactions restricted the water uptake in ASDs and provided effective crystallization inhibition in presence of water.

Subjects/Keywords: Pharmaceutical sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mistry, P. (2016). Strength of drug-polymer interactions: Implications on molecular mobility and crystallization in amorphous dispersions. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/201501

Chicago Manual of Style (16^th Edition):

Mistry, Pinal. “Strength of drug-polymer interactions: Implications on molecular mobility and crystallization in amorphous dispersions.” 2016. Doctoral Dissertation, University of Minnesota. Accessed February 25, 2020. http://hdl.handle.net/11299/201501.

MLA Handbook (7^th Edition):

Mistry, Pinal. “Strength of drug-polymer interactions: Implications on molecular mobility and crystallization in amorphous dispersions.” 2016. Web. 25 Feb 2020.

Vancouver:

Mistry P. Strength of drug-polymer interactions: Implications on molecular mobility and crystallization in amorphous dispersions. [Internet] [Doctoral dissertation]. University of Minnesota; 2016. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/11299/201501.

Council of Science Editors:

Mistry P. Strength of drug-polymer interactions: Implications on molecular mobility and crystallization in amorphous dispersions. [Doctoral Dissertation]. University of Minnesota; 2016. Available from: http://hdl.handle.net/11299/201501

University of Kansas

30. Jakaria, Sardar M. A Systematic Degradation Kinetics Study of Gemcitabine Hydrochloride Injection Solution.

Degree: MS, Pharmaceutical Chemistry, 2017, University of Kansas

URL: http://hdl.handle.net/1808/26163

► This study was carried out to systematically evaluate the degradation kinetics of gemcitabine hydrochloride injection solution over the pH region 1–12 at 70°C. The degradation… (more)

Subjects/Keywords: Pharmaceutical sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jakaria, S. M. (2017). A Systematic Degradation Kinetics Study of Gemcitabine Hydrochloride Injection Solution. (Masters Thesis). University of Kansas. Retrieved from http://hdl.handle.net/1808/26163

Chicago Manual of Style (16^th Edition):

Jakaria, Sardar M. “A Systematic Degradation Kinetics Study of Gemcitabine Hydrochloride Injection Solution.” 2017. Masters Thesis, University of Kansas. Accessed February 25, 2020. http://hdl.handle.net/1808/26163.

MLA Handbook (7^th Edition):

Jakaria, Sardar M. “A Systematic Degradation Kinetics Study of Gemcitabine Hydrochloride Injection Solution.” 2017. Web. 25 Feb 2020.

Vancouver:

Jakaria SM. A Systematic Degradation Kinetics Study of Gemcitabine Hydrochloride Injection Solution. [Internet] [Masters thesis]. University of Kansas; 2017. [cited 2020 Feb 25]. Available from: http://hdl.handle.net/1808/26163.

Council of Science Editors:

Jakaria SM. A Systematic Degradation Kinetics Study of Gemcitabine Hydrochloride Injection Solution. [Masters Thesis]. University of Kansas; 2017. Available from: http://hdl.handle.net/1808/26163

Open Access Theses and Dissertations