subject:(Pharmaceutical Preparations)

University of Louisville

1. Shaffer, Frederic E. Studies on spinal anesthesia.

Degree: MS, 1945, University of Louisville

URL: 10.18297/etd/2165 ; https://ir.library.louisville.edu/etd/2165

Subjects/Keywords: Pharmaceutical Preparations

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APA (6^th Edition):

Shaffer, F. E. (1945). Studies on spinal anesthesia. (Masters Thesis). University of Louisville. Retrieved from 10.18297/etd/2165 ; https://ir.library.louisville.edu/etd/2165

Chicago Manual of Style (16^th Edition):

Shaffer, Frederic E. “Studies on spinal anesthesia.” 1945. Masters Thesis, University of Louisville. Accessed April 13, 2021. 10.18297/etd/2165 ; https://ir.library.louisville.edu/etd/2165.

MLA Handbook (7^th Edition):

Shaffer, Frederic E. “Studies on spinal anesthesia.” 1945. Web. 13 Apr 2021.

Vancouver:

Shaffer FE. Studies on spinal anesthesia. [Internet] [Masters thesis]. University of Louisville; 1945. [cited 2021 Apr 13]. Available from: 10.18297/etd/2165 ; https://ir.library.louisville.edu/etd/2165.

Council of Science Editors:

Shaffer FE. Studies on spinal anesthesia. [Masters Thesis]. University of Louisville; 1945. Available from: 10.18297/etd/2165 ; https://ir.library.louisville.edu/etd/2165

2. Gala, Urvi. Preparation, Characterization and Dissolution Study for Curcumin-Resveratrol-Cyclodextrin Amorphous Ternary System.

Degree: M.S. in Pharmaceutical Sciences, Pharmaceutical Science (graduate program), 2015, Creighton University

URL: http://hdl.handle.net/10504/71148

► Curcumin and resveratrol are naturally occurring polyphenolic compounds, showing synergistic potential in treatment of several chronic disorders. However, their poor oral bioavailability, which is primarily… (more)

▼ Curcumin and resveratrol are naturally occurring polyphenolic compounds, showing synergistic potential in treatment of several chronic disorders. However, their poor oral bioavailability, which is primarily due to limited aqueous solubility, is a major hurdle in tapping their synergistic potential for therapeutic purposes. Cyclodextrins are oligosaccharides which shield hydrophobic functionalities and enhance aqueous solubility of compounds. The objective of present research was to prepare and characterize curcumin-resveratrol-cyclodextrin amorphous ternary systems, for simultaneous dissolution enhancement of both drugs. |Ultraviolet-Visible (UV-Vis) spectroscopy method was developed for simultaneous quantification of drugs. Alpha(α)-cyclodextrin, beta(β)–cyclodextrin, gamma(γ)–cyclodextrin and hydroxyl propyl beta(HPβ)–cyclodextrin were screened for their apparent aqueous solubility enhancement ability for curcumin and resveratrol. HPβ–cyclodextrin was found to be most effective. Solid dispersions in molar ratios of 1:1:2 (curcumin:resveratrol:each cyclodextrin), were prepared using solvent evaporation method and characterized by light microscopy, scanning electron microscopy(SEM), thermogravimetric analysis(TGA), modulated differential scanning calorimetry(MDSC), X-ray powder diffraction(XRPD), infrared(IR) spectroscopy, and Raman spectroscopy. Solid dispersions appeared to have irregular morphology and optimum thermal stability. Both drugs showed sharp melting peaks which disappeared in HPβ-cyclodextrin based solid dispersion, indicating reduction in their crystallinity. XRPD study showed HPβ-cyclodextrin based solid dispersion was amorphous in nature. IR spectroscopy indicated H-bonding between drugs and cyclodextrin, Raman spectroscopy indicated shielding of drugs by cyclodextrin cavity. Dissolution of HPβ-cyclodextrin based solvent evaporated solid dispersion and corresponding physical mixture was carried out in USP type II apparatus with phosphate buffer pH 7.4. Within 30 minutes, dissolution enhancement of 2.4 fold was achieved for curcumin via solid dispersion compared to physical mixture, 55.3% of resveratrol was released from solid dispersion compared to 23.3% from physical mixture. |Solid dispersions of curcumin and/or resveratrol and HPβ-cyclodextrin were prepared by freeze drying using acetone:water, water solvent systems, and characterized. Dissolution study showed that within 5 minutes, 98% of curcumin and 100% of resveratrol were released from acetone:water based solid dispersion. |Thus, HPβ-cyclodextrin based solid dispersion appeared effective for simultaneous dissolution enhancement of curcumin and resveratrol. Freeze drying emerged as more suitable method owing to limited use of organic solvents. In-vitro efficacy of solid dispersions should be explored in future. Advisors/Committee Members: Chauhan, Harsh (advisor), Gala, Urvi (cuauthor).

Subjects/Keywords: Chemistry, Pharmaceutical – methods; Pharmaceutical Preparations – chemistry

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APA (6^th Edition):

Gala, U. (2015). Preparation, Characterization and Dissolution Study for Curcumin-Resveratrol-Cyclodextrin Amorphous Ternary System. (Masters Thesis). Creighton University. Retrieved from http://hdl.handle.net/10504/71148

Chicago Manual of Style (16^th Edition):

Gala, Urvi. “Preparation, Characterization and Dissolution Study for Curcumin-Resveratrol-Cyclodextrin Amorphous Ternary System.” 2015. Masters Thesis, Creighton University. Accessed April 13, 2021. http://hdl.handle.net/10504/71148.

MLA Handbook (7^th Edition):

Gala, Urvi. “Preparation, Characterization and Dissolution Study for Curcumin-Resveratrol-Cyclodextrin Amorphous Ternary System.” 2015. Web. 13 Apr 2021.

Vancouver:

Gala U. Preparation, Characterization and Dissolution Study for Curcumin-Resveratrol-Cyclodextrin Amorphous Ternary System. [Internet] [Masters thesis]. Creighton University; 2015. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/10504/71148.

Council of Science Editors:

Gala U. Preparation, Characterization and Dissolution Study for Curcumin-Resveratrol-Cyclodextrin Amorphous Ternary System. [Masters Thesis]. Creighton University; 2015. Available from: http://hdl.handle.net/10504/71148

3. Bhujbal, Sonal. Preparation, Characterization and In Vitro Evaluation of Metformin Loaded Hyaluronic Acid Nanoparticles for Oral Delivery.

Degree: M.S. in Pharmaceutical Sciences, Pharmaceutical Science (graduate program), 2016, Creighton University

URL: http://hdl.handle.net/10504/90244

► Metformin, an anti-diabetic drug, has a low oral bioavailability (50-60%) due to its poor intestinal absorption. Orally administered mucoadhesive nanoparticles have been shown to interact… (more)

▼ Metformin, an anti-diabetic drug, has a low oral bioavailability (50-60%) due to its poor intestinal absorption. Orally administered mucoadhesive nanoparticles have been shown to interact with the intestinal mucus layer and increase the intestinal permeability of the entrapped drug. The objective of the present study was to develop and characterize polymeric nanoparticulate system containing metformin with a mucoadhesive polymer hyaluronic acid. Blank and drug loaded nanoparticles were prepared using hyaluronic acid polymer by precipitation method with a high entrapment efficiency. The average particle size of the blank and drug loaded nanoparticles was found to be 155.52 ±18.70 nm and 114.53 ± 12.01 nm, respectively. Atomic force microscopy (AFM) revealed that the nanostructures were in form of nanofibres. Zeta potential was found to be in the range of -0.27 to 0.24 mV. Physical stability studies indicated that the particle size was maintained at < 200 nm, and no change in zeta potential values over a period of 65 days. Differential Scanning Calorimetry and X-ray diffraction analysis indicated that the drug was present in a crystalline state in the matrix. The in vitro drug release studies showed that >50% of metformin was released within one hour. Metformin nanoparticles were non-toxic at a concentration of ≤ 100 µM in Cacco-2 cells. Haemolysis studies indicated that these nanoparticles can also be safely administered via intravenous route. Cellular uptake studies on Caco-2 cells indicated higher uptake of metformin from nanoparticle relative to that from metformin solution, up to first 45 minutes. Permeability studies indicated no passive permeation of the nanoparticles through a synthetic membrane lacking mucin. Thus requires further in vivo studies in the future with more bio-relevant environment like Caco-2 cells or porcine intestine. Diabetes is a disease affecting millions of people globally. The outcomes of this study could increase bioavailability, reduce dose and side effects of the metformin (widely used first line therapy for type 2 diabetes) which could impact humanity globally. Advisors/Committee Members: Dash, Alekha (advisor), Bhujbal, Sonal (cuauthor).

Subjects/Keywords: Metformin – pharmacology;

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APA (6^th Edition):

Bhujbal, S. (2016). Preparation, Characterization and In Vitro Evaluation of Metformin Loaded Hyaluronic Acid Nanoparticles for Oral Delivery. (Masters Thesis). Creighton University. Retrieved from http://hdl.handle.net/10504/90244

Chicago Manual of Style (16^th Edition):

Bhujbal, Sonal. “Preparation, Characterization and In Vitro Evaluation of Metformin Loaded Hyaluronic Acid Nanoparticles for Oral Delivery.” 2016. Masters Thesis, Creighton University. Accessed April 13, 2021. http://hdl.handle.net/10504/90244.

MLA Handbook (7^th Edition):

Bhujbal, Sonal. “Preparation, Characterization and In Vitro Evaluation of Metformin Loaded Hyaluronic Acid Nanoparticles for Oral Delivery.” 2016. Web. 13 Apr 2021.

Vancouver:

Bhujbal S. Preparation, Characterization and In Vitro Evaluation of Metformin Loaded Hyaluronic Acid Nanoparticles for Oral Delivery. [Internet] [Masters thesis]. Creighton University; 2016. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/10504/90244.

Council of Science Editors:

Bhujbal S. Preparation, Characterization and In Vitro Evaluation of Metformin Loaded Hyaluronic Acid Nanoparticles for Oral Delivery. [Masters Thesis]. Creighton University; 2016. Available from: http://hdl.handle.net/10504/90244

Duquesne University

4. Wang, Yiwei. Macromolecule Loading on PLGA Particles through Surface Adsorption.

Degree: MS, Pharmaceutics, 2018, Duquesne University

URL: https://dsc.duq.edu/etd/1488

► The advent of biotherapeutics have impacted the ways in which diseases are treated. In many instances development of recombinant proteins and oligonucleotides into therapeutics… (more)

▼ The advent of biotherapeutics have impacted the ways in which diseases are treated. In many instances development of recombinant proteins and oligonucleotides into therapeutics are slowed by poor stability of the candidate drugs. Progress has been made in using polymeric particles as carriers of macromolecule drugs. Historically the method is to encapsulate biological drugs into spherical polymeric matrices. Owing to its biocompatible and biodegradable nature, poly (d,l-lactic-co-glycolic acid) (PLGA) has been used extensively in formulating biological drugs into nano- and micro-sized particles. The development of PLGA biologic formulations, however, has been hampered by matrix acidification; the hydrolysis of the polymer generates non-diffusive acid fragments by which the interior pH can be driven to as low as 2, a condition unfavorable for proteins and oligonucleotides to remain intact. In addition, loading of proteins through encapsulation can lead to substantial loss of activity because of homogenization or sonication-induced denaturation. To circumvent these limitations yet still take advantage of the proven safety of PLGA in humans, I proposed to load macromolecules onto the surface of PLGA particles functionalized with biotin (“PLGA-biotin”). The specific binding between avidin and biotin (or desthiobiotin) was employed to enable surface adsorption. The pair has the strongest known non-covalent affinity, an interaction that is relatively insensitive to temperature and pH. PLGA-biotin particles were prepared by co-emulsifying the lipid DSPE-PEG-biotin with PLGA into a matrix. The tetravalent feature of avidin was used to bridge biotinylated proteins or oligonucleotides onto PLGA- biotin particles. The hypothesis of this project is that solvent-accessible biotin molecules are displayed on PLGA-biotin particles. The rationale for my hypothesis is that the co- emulsification of the biotinylated lipid DSPE-PEG-biotin and the polymer matrix PLGA has the potential to generate PLGA particles functionalized with biotin molecules embedded on the surface. As a result, the interaction between biotin and avidin can be utilized to load macromolecules onto the surface of these modified PLGA particles through adsorption, circumventing the challenges to the stability and bioactivity of the biological drugs caused by the encapsulation process and the acidic environment inside PLGA particles during the degradation of the polymer matrix. Two specific aims were carried out. In aim 1, the presence of biotin in PLGA-biotin particles was verified and the physical attributes of the particles, namely particle size and zeta potential, were characterized. Spectroscopic and biochemical studies indicated the presence of biotin on the particle surface. In aim 2, the amount of biotin accessible on PLGA-biotin particles was quantified. Taken together, the data generated in this thesis support the notion that surface adsorption is a general method for loading macromolecules onto PLGA particles. The work presented is a step toward a… Advisors/Committee Members: Wilson Meng, Ellen Gawalt, Devika Soundara Manickam.

Subjects/Keywords: PLGA; avidin; biotin; adsorption; Pharmaceutical Preparations

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APA (6^th Edition):

Wang, Y. (2018). Macromolecule Loading on PLGA Particles through Surface Adsorption. (Thesis). Duquesne University. Retrieved from https://dsc.duq.edu/etd/1488

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Yiwei. “Macromolecule Loading on PLGA Particles through Surface Adsorption.” 2018. Thesis, Duquesne University. Accessed April 13, 2021. https://dsc.duq.edu/etd/1488.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Yiwei. “Macromolecule Loading on PLGA Particles through Surface Adsorption.” 2018. Web. 13 Apr 2021.

Vancouver:

Wang Y. Macromolecule Loading on PLGA Particles through Surface Adsorption. [Internet] [Thesis]. Duquesne University; 2018. [cited 2021 Apr 13]. Available from: https://dsc.duq.edu/etd/1488.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang Y. Macromolecule Loading on PLGA Particles through Surface Adsorption. [Thesis]. Duquesne University; 2018. Available from: https://dsc.duq.edu/etd/1488

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

5. Koerner, John C. An exploration into automated clinical drug classification.

Degree: M.B.I., 2009, Oregon Health Sciences University

URL: doi:10.6083/M4PK0D4N ; http://digitalcommons.ohsu.edu/etd/428

Subjects/Keywords: Pharmaceutical Preparations – classification; Medical Informatics

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APA (6^th Edition):

Koerner, J. C. (2009). An exploration into automated clinical drug classification. (Thesis). Oregon Health Sciences University. Retrieved from doi:10.6083/M4PK0D4N ; http://digitalcommons.ohsu.edu/etd/428

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Koerner, John C. “An exploration into automated clinical drug classification.” 2009. Thesis, Oregon Health Sciences University. Accessed April 13, 2021. doi:10.6083/M4PK0D4N ; http://digitalcommons.ohsu.edu/etd/428.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Koerner, John C. “An exploration into automated clinical drug classification.” 2009. Web. 13 Apr 2021.

Vancouver:

Koerner JC. An exploration into automated clinical drug classification. [Internet] [Thesis]. Oregon Health Sciences University; 2009. [cited 2021 Apr 13]. Available from: doi:10.6083/M4PK0D4N ; http://digitalcommons.ohsu.edu/etd/428.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Koerner JC. An exploration into automated clinical drug classification. [Thesis]. Oregon Health Sciences University; 2009. Available from: doi:10.6083/M4PK0D4N ; http://digitalcommons.ohsu.edu/etd/428

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Utah

6. Tang, Aijun. A lymphocyte-targeting polymeric drug delivery system mediated by receptor-binding epitopes: design, synthesis, and characterization.

Degree: PhD, Pharmaceutics & Pharmaceutical Chemistry;, 2002, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1096/rec/26

► Extensive studies have demonstrated that the use of targetable polymeric drug delivery systems is an efficient approach for improving cancer chemotherapy. In this dissertation, a… (more)

▼ Extensive studies have demonstrated that the use of targetable polymeric drug delivery systems is an efficient approach for improving cancer chemotherapy. In this dissertation, a new strategy for the design of targetable polymeric anticancer drug carriers was proposed that combined water-soluble polymers with epitopes recognizing cell surface receptors. The research investigated the biorecognizability of receptor-binding epitopes presented on structure-simplified peptide templates, and explored the feasibility of transplanting these epitopes to a water-soluble polymer conjugate system for receptor-specific recognition of target cells. The specific objectives of this project were accomplished in three steps. The first step was model establishment. A peptide template containing a nonapeptide epitope as a ligand for B cell CD21 receptor was designed and synthesized by genetic engineering methods. The peptide was immobilized on a solid substrate in an oriented manner and the recognizability of the epitope was evaluated. The results demonstrated the applicability of this model system to display epitopes for biorecognition studies. In the second step, a series of nonapeptide-related peptides were incorporated into a coiled coil stem loop peptide template, and the recognition of these peptides was studied using isolated receptor and receptor-bearing cells. These peptides exhibited varying receptor-binding affinities, thereby revealing their potential as targeting moieties. The last step focused on the synthesis of epitope-containing polymer conjugates and evaluation of their recognizability and cytotoxicity using experimental cell lines. It was found that the epitopes induced specific binding of the conjugates to the target cells and significantly enhanced the cytotoxic activity of polymer-bound doxorubicin. This work describes a potential strategy toward the targeted delivery of anticancer drugs to a subset of lymphocytes for the treatment of lymphoma and leukemia. It is speculated that the combination of water-soluble polymers with receptor-binding epitopes may be applicable to other ligand-receptor systems, and that polymer-based therapeutics can be tailored to specific malignancies.

Subjects/Keywords: Pharmaceutical Preparations; Drug Delivery Systems

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APA (6^th Edition):

Tang, A. (2002). A lymphocyte-targeting polymeric drug delivery system mediated by receptor-binding epitopes: design, synthesis, and characterization. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1096/rec/26

Chicago Manual of Style (16^th Edition):

Tang, Aijun. “A lymphocyte-targeting polymeric drug delivery system mediated by receptor-binding epitopes: design, synthesis, and characterization.” 2002. Doctoral Dissertation, University of Utah. Accessed April 13, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1096/rec/26.

MLA Handbook (7^th Edition):

Tang, Aijun. “A lymphocyte-targeting polymeric drug delivery system mediated by receptor-binding epitopes: design, synthesis, and characterization.” 2002. Web. 13 Apr 2021.

Vancouver:

Tang A. A lymphocyte-targeting polymeric drug delivery system mediated by receptor-binding epitopes: design, synthesis, and characterization. [Internet] [Doctoral dissertation]. University of Utah; 2002. [cited 2021 Apr 13]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1096/rec/26.

Council of Science Editors:

Tang A. A lymphocyte-targeting polymeric drug delivery system mediated by receptor-binding epitopes: design, synthesis, and characterization. [Doctoral Dissertation]. University of Utah; 2002. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1096/rec/26

7. Meng, Fan. Investigating Crystallization Tendency, Miscibility and Molecular interactions of drug-polymer systems for the development of amorphous solid dispersions.

Degree: M.S. in Pharmaceutical Sciences, Pharmaceutical Science (graduate program), 2015, Creighton University

URL: http://hdl.handle.net/10504/71263

► This project aims to characterize the crystallization tendencies, miscibility and molecular interaction in drug-polymer systems of poorly soluble drugs and correlate it with the performance… (more)

▼ This project aims to characterize the crystallization tendencies, miscibility and molecular interaction in drug-polymer systems of poorly soluble drugs and correlate it with the performance of prepared or reported SDs (solid dispersions). Crystallization tendencies of five different drugs [i.e. Curcumin (CUR), indomethacin (IND), flutaminde (FLU), dipyridamole (DIP), griseofulvin (GRI)] in absence and presence of four different polymers [i.e. polyethylene glycol (PEG), eudragit EPO (EPO), hydroxypropyl methylcellulose (HPMC) and polyvinyl pyrrolidone (PVP)] in various drug-polymer ratios were determined by using modulated differential scanning calorimetry (MDSC). Thermal analysis i.e. glass transition temperature (Tg), crystallinity and melting point depression along with theoretical calculations such as solubility parameter were performed to study drug polymer miscibility. Molecular interactions were predicted by using Tg deviations and molecular modeling. Physical states of drug in the SDs were characterized by X-ray diffraction (XRD) and MDSC. IR (Infrared) and Raman were used in selected systems (i.e. CUR, DIP and GRI systems) to explore the role of drug polymer interactions in amorphization of SDs. Dissolution studies using USP apparatus II and physical stability study at room temperature were performed for selected systems. Based on the absence and presence of endothermic and exothermic peaks (heat-cool-heat cycle) in MDSC, the crystallization tendency of pure drugs was categorized as low, moderate and high. In presence of selected polymers, crystallization tendency of all the drugs can be modified albeit high polymer concentration was required for drugs with high crystallization tendency i.e. DIP and GRI (> 50%w/w). Polymers showing greater effect on crystallization tendency of drugs were found to have higher drug-polymer miscibility and stronger molecular interactions. For example, FLU- PVP system showed good miscibility and no remarkable Tg deviation. This is reflected in its ability to change the crystallization tendency of FLU. Further, the results correlated well with the physical state, dissolution and stability of prepared/reported SDs. The developed approach has significant potential to be a rational screening method for the development of amorphous SDs. Advisors/Committee Members: Chauhan, Harsh V. (advisor), Meng, Fan (cuauthor).

Subjects/Keywords: Pharmaceutical Preparations – chemistry; Polymers – chemistry; Calorimetry, Differential Scanning; Solubility

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APA (6^th Edition):

Meng, F. (2015). Investigating Crystallization Tendency, Miscibility and Molecular interactions of drug-polymer systems for the development of amorphous solid dispersions. (Masters Thesis). Creighton University. Retrieved from http://hdl.handle.net/10504/71263

Chicago Manual of Style (16^th Edition):

Meng, Fan. “Investigating Crystallization Tendency, Miscibility and Molecular interactions of drug-polymer systems for the development of amorphous solid dispersions.” 2015. Masters Thesis, Creighton University. Accessed April 13, 2021. http://hdl.handle.net/10504/71263.

MLA Handbook (7^th Edition):

Meng, Fan. “Investigating Crystallization Tendency, Miscibility and Molecular interactions of drug-polymer systems for the development of amorphous solid dispersions.” 2015. Web. 13 Apr 2021.

Vancouver:

Meng F. Investigating Crystallization Tendency, Miscibility and Molecular interactions of drug-polymer systems for the development of amorphous solid dispersions. [Internet] [Masters thesis]. Creighton University; 2015. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/10504/71263.

Council of Science Editors:

Meng F. Investigating Crystallization Tendency, Miscibility and Molecular interactions of drug-polymer systems for the development of amorphous solid dispersions. [Masters Thesis]. Creighton University; 2015. Available from: http://hdl.handle.net/10504/71263

University of Utah

8. Charles, Bradley Kent. Opiate recidivism in a drug treatment program: comparison of hair and urine data using a liquid chromatography mass spectrometry method;.

Degree: MS;, Pathology;, 2003, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/27/rec/929

► The objective of this preliminary study was to determine whether hair can be used as an adjunct specimen for the monitoring of opiate use in… (more)

Subjects/Keywords: Pharmaceutical Preparations; Drug Testing

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APA (6^th Edition):

Charles, B. K. (2003). Opiate recidivism in a drug treatment program: comparison of hair and urine data using a liquid chromatography mass spectrometry method;. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/27/rec/929

Chicago Manual of Style (16^th Edition):

Charles, Bradley Kent. “Opiate recidivism in a drug treatment program: comparison of hair and urine data using a liquid chromatography mass spectrometry method;.” 2003. Masters Thesis, University of Utah. Accessed April 13, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/27/rec/929.

MLA Handbook (7^th Edition):

Charles, Bradley Kent. “Opiate recidivism in a drug treatment program: comparison of hair and urine data using a liquid chromatography mass spectrometry method;.” 2003. Web. 13 Apr 2021.

Vancouver:

Charles BK. Opiate recidivism in a drug treatment program: comparison of hair and urine data using a liquid chromatography mass spectrometry method;. [Internet] [Masters thesis]. University of Utah; 2003. [cited 2021 Apr 13]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/27/rec/929.

Council of Science Editors:

Charles BK. Opiate recidivism in a drug treatment program: comparison of hair and urine data using a liquid chromatography mass spectrometry method;. [Masters Thesis]. University of Utah; 2003. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/27/rec/929

9. Ahmad, Yasmin. Quantitative analysis of drugs in pharmaceutical preparations; -.

Degree: Chemistry, 2004, Aligarh Muslim University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/53627

Abstract available newline newline

-

Advisors/Committee Members: Rahman, Nafisur.

Subjects/Keywords: Quantitative; Pharmaceutical; Preparations; Analysis; Relation

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APA (6^th Edition):

Ahmad, Y. (2004). Quantitative analysis of drugs in pharmaceutical preparations; -. (Thesis). Aligarh Muslim University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/53627

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ahmad, Yasmin. “Quantitative analysis of drugs in pharmaceutical preparations; -.” 2004. Thesis, Aligarh Muslim University. Accessed April 13, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/53627.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ahmad, Yasmin. “Quantitative analysis of drugs in pharmaceutical preparations; -.” 2004. Web. 13 Apr 2021.

Vancouver:

Ahmad Y. Quantitative analysis of drugs in pharmaceutical preparations; -. [Internet] [Thesis]. Aligarh Muslim University; 2004. [cited 2021 Apr 13]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/53627.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ahmad Y. Quantitative analysis of drugs in pharmaceutical preparations; -. [Thesis]. Aligarh Muslim University; 2004. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/53627

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Western Kentucky University

10. Wang, Ban. Synthesis of Bis(imino)pyridine Iron(II) Complexes and Development of Bis(imino)pyridine Iron(II) Catalyzed Carbene Transfer Reactions.

Degree: MS, Department of Chemistry, 2019, Western Kentucky University

URL: https://digitalcommons.wku.edu/theses/3159

► Metal catalysis of symmetric and asymmetric carbene transfer reactions has been widely applied in natural product synthesis and material science over years. Metal carbene… (more)

▼ Metal catalysis of symmetric and asymmetric carbene transfer reactions has been widely applied in natural product synthesis and material science over years. Metal carbene can be easily generated from the extrusion of nitrogen under the catalysis of metal complexes to further undergo various organic reactions, O/N/C-H insertions, cycloadditions, and ylide formations. Currently, the dominant effective catalysts for carbene reactions are built with expensive precious metal, for example, rhodium, ruthenium, palladium, gold. Notably, the effective reactivity and enantioselectivity of the dirhodium(II) catalysts are researched and established over the decades. However, the use of precious metal catalysts is the major source of metal residues in pharmaceutical products; thus, it becomes a concerning safety factor towards the environment. Iron, instead, to our interest, is an economical and ecofriendly element. Iron has been used in different catalytic reactions but achieved moderate reactivity and low enantioselectivity towards carbene transfer reactions. Within, the electronic environment and the mechanism of iron catalysts are underdeveloped. A new series of ligands named bis(imino)pyridine family has been found to be able to offer coordinate sites for transition metals to build effective metal complexes can be used for different organic reactions. This type of ligand can be easily synthesized in relatively short steps and the structure of the substituents can be facially tuned. These advantages show the great potential of bis(imino)pyridine ligands in organic catalysis. In this project, bis(imino)pyridine ligands were applied as the backbone structure to construct a series of achiral and chiral iron catalysts that were investigated in catalytic metal carbene reactions in terms of reactivity and selectivity. By manipulating the structure of the ligands, the high reactivity of the achiral iron(II) complexes towards various carbene reactions was achieved, while moderate enantioselectivity was observed by the catalysis of chiral iron(II) complexes. To our delight, the bis(imino)pyridine iron(II) complex, for the first time, is shown as an effective metal carbene catalyst for carbene transfer reactions of donor–acceptor diazo compounds. Its broad catalytic capability is demonstrated by a range of metal carbene reactions, from cyclopropanation, cyclopropenation, epoxidation, and Doyle–Kirmse reaction to O–H insertion, N–H insertion, and C–H insertion reactions. The asymmetric cyclopropanation of styrene and methyl phenyldiazoacetate was successfully achieved by the new chiral bis(imino)pyridine iron catalyst, which delivers a new gateway for the development of chiral iron catalysis for metal carbene reactions. Advisors/Committee Members: Dr. Yongming Deng (Director), Dr. Rui Zhang and Dr. Kevin Williams.

Subjects/Keywords: Organic Chemistry; Pharmaceutical Preparations; Pharmaceutics and Drug Design

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APA (6^th Edition):

Wang, B. (2019). Synthesis of Bis(imino)pyridine Iron(II) Complexes and Development of Bis(imino)pyridine Iron(II) Catalyzed Carbene Transfer Reactions. (Masters Thesis). Western Kentucky University. Retrieved from https://digitalcommons.wku.edu/theses/3159

Chicago Manual of Style (16^th Edition):

Wang, Ban. “Synthesis of Bis(imino)pyridine Iron(II) Complexes and Development of Bis(imino)pyridine Iron(II) Catalyzed Carbene Transfer Reactions.” 2019. Masters Thesis, Western Kentucky University. Accessed April 13, 2021. https://digitalcommons.wku.edu/theses/3159.

MLA Handbook (7^th Edition):

Wang, Ban. “Synthesis of Bis(imino)pyridine Iron(II) Complexes and Development of Bis(imino)pyridine Iron(II) Catalyzed Carbene Transfer Reactions.” 2019. Web. 13 Apr 2021.

Vancouver:

Wang B. Synthesis of Bis(imino)pyridine Iron(II) Complexes and Development of Bis(imino)pyridine Iron(II) Catalyzed Carbene Transfer Reactions. [Internet] [Masters thesis]. Western Kentucky University; 2019. [cited 2021 Apr 13]. Available from: https://digitalcommons.wku.edu/theses/3159.

Council of Science Editors:

Wang B. Synthesis of Bis(imino)pyridine Iron(II) Complexes and Development of Bis(imino)pyridine Iron(II) Catalyzed Carbene Transfer Reactions. [Masters Thesis]. Western Kentucky University; 2019. Available from: https://digitalcommons.wku.edu/theses/3159

University of Aberdeen

11. Nebot, Carolina.; UHI Millennium Institute. Assessing the presence of human pharmaceuticals in the Scottish aquatic environment.

Degree: 2010, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=163150 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=163150&custom_att_2=simple_viewer

Subjects/Keywords: Water; Pharmaceutical preparations.; Environment; Groundwater

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APA (6^th Edition):

Nebot, C. ;. U. M. I. (2010). Assessing the presence of human pharmaceuticals in the Scottish aquatic environment. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=163150 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=163150&custom_att_2=simple_viewer

Chicago Manual of Style (16^th Edition):

Nebot, Carolina ; UHI Millennium Institute. “Assessing the presence of human pharmaceuticals in the Scottish aquatic environment.” 2010. Doctoral Dissertation, University of Aberdeen. Accessed April 13, 2021. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=163150 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=163150&custom_att_2=simple_viewer.

MLA Handbook (7^th Edition):

Nebot, Carolina ; UHI Millennium Institute. “Assessing the presence of human pharmaceuticals in the Scottish aquatic environment.” 2010. Web. 13 Apr 2021.

Vancouver:

Nebot C;UMI. Assessing the presence of human pharmaceuticals in the Scottish aquatic environment. [Internet] [Doctoral dissertation]. University of Aberdeen; 2010. [cited 2021 Apr 13]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=163150 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=163150&custom_att_2=simple_viewer.

Council of Science Editors:

Nebot C;UMI. Assessing the presence of human pharmaceuticals in the Scottish aquatic environment. [Doctoral Dissertation]. University of Aberdeen; 2010. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=163150 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=163150&custom_att_2=simple_viewer

12. Byrne, Jonathan. Analytical Studies Concerning the Stability of Betamethasone Valerate and Fusidic acid Hemihydrate in Topical Pharmaceutical Preparations.

Degree: 2018, RIAN

URL: http://mural.maynoothuniversity.ie/10761/

► The research work presented in this thesis describes studies concerning the stability of the drug substances betamethasone 17-valerate and fusidic acid hemihydrate in topical pharmaceutical… (more)

▼ The research work presented in this thesis describes studies concerning the stability of the drug substances betamethasone 17-valerate and fusidic acid hemihydrate in topical pharmaceutical formulations. In particular, the work concentrates on formulation factors affecting the intra-molecular isomerisation of betamethasone 17-valerate to 21-valerate in a developmental topical cream for treatment of atopic dermatitis and psoriasis. Appropriate analytical tools for the simultaneous analysis of both drug substances have been developed and their suitability for use in the study demonstrated by validation experiments. The results of the isomerisation study indicate that the concentration of the emulsifier macrogolstearylether-21 significantly influences the isomerisation rate of the glucocorticoid. 5 % (w/w) of this substance in the formulation resulted in complete isomerisation within a number of months, whereas 1.5 % (w/w) gave rise to less than 3 % isomerisation after 3 years storage. The study data was used to develop a new topical drug formulation containing both betamethasone 17-valerate and fusidic acid which went to market in early 2017. Additionally, the influence of the polymorphic form of fusidic acid on its stability was investigated. Fusidic acid is known to exist in 4 polymorphic modifications and this study has shown that polymorphic forms I and III are currently available on the commercial market. Intrinsic dissolution – and in-vitro permeation studies demonstrate that both polymorphs have similar intrinsic dissolution rates, as well as comparable in-vitro release rates from the developmental cream. This indicates that both forms may be used interchangeably without affecting the safety and efficacy of concerned drug products. Finally, the plausibility of incorporating both drug substances into electrospun poly(caprolactone) (PCL) microfibers for potential use as an occlusive medicated dressing was examined. The effect of addition of the novel low molecular weight gelator, Fmoc-OH-C18, on the manufacture of the microfibers as well as on their in-vitro drug release rates was studied. The gelator was found to have a profound effect on the morphology of the resulting fibers but had little effect on the release rate of the active drug substances. The results suggest that the use of a medicated electrospun dressing containing betamethasone valerate and fusidic acid might be a viable treatment alternative to the current topical dosage forms. However, significant further work is needed in this regard.

Subjects/Keywords: Analytical Studies; Stability; Betamethasone Valerate; Fusidic acid Hemihydrate; Topical Pharmaceutical Preparations

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APA (6^th Edition):

Byrne, J. (2018). Analytical Studies Concerning the Stability of Betamethasone Valerate and Fusidic acid Hemihydrate in Topical Pharmaceutical Preparations. (Thesis). RIAN. Retrieved from http://mural.maynoothuniversity.ie/10761/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Byrne, Jonathan. “Analytical Studies Concerning the Stability of Betamethasone Valerate and Fusidic acid Hemihydrate in Topical Pharmaceutical Preparations.” 2018. Thesis, RIAN. Accessed April 13, 2021. http://mural.maynoothuniversity.ie/10761/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Byrne, Jonathan. “Analytical Studies Concerning the Stability of Betamethasone Valerate and Fusidic acid Hemihydrate in Topical Pharmaceutical Preparations.” 2018. Web. 13 Apr 2021.

Vancouver:

Byrne J. Analytical Studies Concerning the Stability of Betamethasone Valerate and Fusidic acid Hemihydrate in Topical Pharmaceutical Preparations. [Internet] [Thesis]. RIAN; 2018. [cited 2021 Apr 13]. Available from: http://mural.maynoothuniversity.ie/10761/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Byrne J. Analytical Studies Concerning the Stability of Betamethasone Valerate and Fusidic acid Hemihydrate in Topical Pharmaceutical Preparations. [Thesis]. RIAN; 2018. Available from: http://mural.maynoothuniversity.ie/10761/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Federal de Mato Grosso do Sul

13. Carvalho, Pamela Castilho de. Diarilsulfetos análogos da combrestatatina A-4: avaliação toxicogenética, imunomodulatória, apoptótica e prospecção de um novo quimioterápico .

Degree: 2014, Universidade Federal de Mato Grosso do Sul

URL: http://repositorio.cbc.ufms.br:8080/jspui/handle/123456789/2169

► A combretastatina A-4 possui eficiente potencial anticancerígeno em tumores humanos e inclusive naqueles resistentes a multidrogas. Esse fato estimulou a pesquisa com dois diarilsulfetos análogos.… (more)

Subjects/Keywords: Toxicogenética; Imunomodulação; Apoptose; Ciclofosfamida; Preparações Farmacêuticas; Toxicogenetics; Immunomodulation; Apoptosis; Cyclophosphamide; Pharmaceutical Preparations

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APA (6^th Edition):

Carvalho, P. C. d. (2014). Diarilsulfetos análogos da combrestatatina A-4: avaliação toxicogenética, imunomodulatória, apoptótica e prospecção de um novo quimioterápico . (Thesis). Universidade Federal de Mato Grosso do Sul. Retrieved from http://repositorio.cbc.ufms.br:8080/jspui/handle/123456789/2169

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Carvalho, Pamela Castilho de. “Diarilsulfetos análogos da combrestatatina A-4: avaliação toxicogenética, imunomodulatória, apoptótica e prospecção de um novo quimioterápico .” 2014. Thesis, Universidade Federal de Mato Grosso do Sul. Accessed April 13, 2021. http://repositorio.cbc.ufms.br:8080/jspui/handle/123456789/2169.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Carvalho, Pamela Castilho de. “Diarilsulfetos análogos da combrestatatina A-4: avaliação toxicogenética, imunomodulatória, apoptótica e prospecção de um novo quimioterápico .” 2014. Web. 13 Apr 2021.

Vancouver:

Carvalho PCd. Diarilsulfetos análogos da combrestatatina A-4: avaliação toxicogenética, imunomodulatória, apoptótica e prospecção de um novo quimioterápico . [Internet] [Thesis]. Universidade Federal de Mato Grosso do Sul; 2014. [cited 2021 Apr 13]. Available from: http://repositorio.cbc.ufms.br:8080/jspui/handle/123456789/2169.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Carvalho PCd. Diarilsulfetos análogos da combrestatatina A-4: avaliação toxicogenética, imunomodulatória, apoptótica e prospecção de um novo quimioterápico . [Thesis]. Universidade Federal de Mato Grosso do Sul; 2014. Available from: http://repositorio.cbc.ufms.br:8080/jspui/handle/123456789/2169

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Cal Poly

14. Tsoi, Eric W. Formulation Development of a Polymer-Drug Matrix with a Controlled Release Profile for the Treatment of Glaucoma.

Degree: MS, Chemistry & Biochemistry, 2013, Cal Poly

URL: https://digitalcommons.calpoly.edu/theses/1134 ; 10.15368/theses.2013.214

► Glaucoma is the leading cause of blindness in the United States accounting for 9-12% of all cases of blindness. Currently, the front line treatment… (more)

Subjects/Keywords: Formulation; Polymer; Controlled Release; Glaucoma; Biomedical Devices and Instrumentation; Pharmaceutical Preparations; Polymer Chemistry

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APA (6^th Edition):

Tsoi, E. W. (2013). Formulation Development of a Polymer-Drug Matrix with a Controlled Release Profile for the Treatment of Glaucoma. (Masters Thesis). Cal Poly. Retrieved from https://digitalcommons.calpoly.edu/theses/1134 ; 10.15368/theses.2013.214

Chicago Manual of Style (16^th Edition):

Tsoi, Eric W. “Formulation Development of a Polymer-Drug Matrix with a Controlled Release Profile for the Treatment of Glaucoma.” 2013. Masters Thesis, Cal Poly. Accessed April 13, 2021. https://digitalcommons.calpoly.edu/theses/1134 ; 10.15368/theses.2013.214.

MLA Handbook (7^th Edition):

Tsoi, Eric W. “Formulation Development of a Polymer-Drug Matrix with a Controlled Release Profile for the Treatment of Glaucoma.” 2013. Web. 13 Apr 2021.

Vancouver:

Tsoi EW. Formulation Development of a Polymer-Drug Matrix with a Controlled Release Profile for the Treatment of Glaucoma. [Internet] [Masters thesis]. Cal Poly; 2013. [cited 2021 Apr 13]. Available from: https://digitalcommons.calpoly.edu/theses/1134 ; 10.15368/theses.2013.214.

Council of Science Editors:

Tsoi EW. Formulation Development of a Polymer-Drug Matrix with a Controlled Release Profile for the Treatment of Glaucoma. [Masters Thesis]. Cal Poly; 2013. Available from: https://digitalcommons.calpoly.edu/theses/1134 ; 10.15368/theses.2013.214

Boise State University

15. Muhammed, Thaaer N. Total Synthesis of 6,7-Dimethyl-N-Methyl Aziridinomitosene.

Degree: 2018, Boise State University

URL: https://scholarworks.boisestate.edu/td/1404

► Mitomycin C (MC) is a naturally occurring antitumor agent isolated from a soil bacterium. MC is effective against solid hypoxic tumors that respond poorly to… (more)

▼ Mitomycin C (MC) is a naturally occurring antitumor agent isolated from a soil bacterium. MC is effective against solid hypoxic tumors that respond poorly to radiotherapy, such as colorectal, gastric, and lung tumors. Also, it has a role in the treatment of bladder, head and neck, and non-small cell lung cancers in combination with other chemotherapeutic. MC and other members of the mitomycin family of antitumor agents fight cancer by forming DNA interstrand crosslinks (ICLs), which leads to apoptosis. In order to form ICLs, MC requires a reductive activation step that produces reactive oxygen species. This activation step is proposed to lead to adverse side effects, such as myelosuppression and hemolytic uremic syndrome. Aziridinomitosenes (AZMs) are structurally related to MC and are believed to form during in vivo reduction of MC. AZMs are relatively stable but are more sensitive than the parent mitomycins due to an activated aziridine ring. Consequently, AZMs do not require the reductive activation step in order to alkylate DNA. The purpose of this work is to synthesize and study an AZM that is substituted with methyl groups at two potential electrophilic sites. It is hypothesized that certain synthetic AZMs crosslink DNA under non-reductive conditions as a result of a nucleophilic activation sequence involving the quinone ring. To test this hypothesis, analogs were prepared that would either reduce the rate of the activation step or prevent it from occurring. The synthetic route starts with commercially available reagents to form an oxazole, followed by the addition of a protected aldehyde that is converted to the required aziridine ring via a Mitsunobu reaction. Once the aziridine ring is formed, all of the reaction conditions must be conducted using mild conditions in order to prevent ring-opening. The completion of the synthesis and formation of the tetracyclic core was achieved by performing an oxazolium salt/azomethine ylide [3+2] cycloaddition sequence. This sequence was conducted multiple times, and the highest yield obtained was 44%. The final steps were the most challenging, requiring several transformations to accomplish a deprotection and oxidation to give a diketone that was oxidized to a quinone. Finally, the carbamate was attached in two steps using FmocNCO to yield the desired AZM product in an overall yield of 0.04% from the starting diol over the 22 step reaction sequence. The stability of the AZM was tested in buffered methanolic solutions, and the results were compared to other aziridinomitosenes. While unsubstituted AZMs decompose in basic solutions, the C6/C7 dimethyl AZM showed high stability under these conditions.

Subjects/Keywords: Mitomycin C; aziridinomitosenes; azomethine ylide; solvolytic stability; Organic Chemicals; Other Chemicals and Drugs; Pharmaceutical Preparations

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APA (6^th Edition):

Muhammed, T. N. (2018). Total Synthesis of 6,7-Dimethyl-N-Methyl Aziridinomitosene. (Thesis). Boise State University. Retrieved from https://scholarworks.boisestate.edu/td/1404

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Muhammed, Thaaer N. “Total Synthesis of 6,7-Dimethyl-N-Methyl Aziridinomitosene.” 2018. Thesis, Boise State University. Accessed April 13, 2021. https://scholarworks.boisestate.edu/td/1404.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Muhammed, Thaaer N. “Total Synthesis of 6,7-Dimethyl-N-Methyl Aziridinomitosene.” 2018. Web. 13 Apr 2021.

Vancouver:

Muhammed TN. Total Synthesis of 6,7-Dimethyl-N-Methyl Aziridinomitosene. [Internet] [Thesis]. Boise State University; 2018. [cited 2021 Apr 13]. Available from: https://scholarworks.boisestate.edu/td/1404.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Muhammed TN. Total Synthesis of 6,7-Dimethyl-N-Methyl Aziridinomitosene. [Thesis]. Boise State University; 2018. Available from: https://scholarworks.boisestate.edu/td/1404

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

16. Damiano, Louis M. The synthesis and study of the biological and colloidal properties of bolaamphiphiles.

Degree: 2015, James Madison University

URL: https://commons.lib.jmu.edu/honors201019/55

► Over the past decade, antibiotic resistant bacteria have caused infections in patients throughout the world.[1] The rise in antibiotic resistance is primarily due to the… (more)

Subjects/Keywords: Bolaamphiphiles; micelles; amphiphiles; CMC; antibacterial; conductivity; Lipids; Organic Chemicals; Organic Chemistry; Pharmaceutical Preparations

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APA (6^th Edition):

Damiano, L. M. (2015). The synthesis and study of the biological and colloidal properties of bolaamphiphiles. (Masters Thesis). James Madison University. Retrieved from https://commons.lib.jmu.edu/honors201019/55

Chicago Manual of Style (16^th Edition):

Damiano, Louis M. “The synthesis and study of the biological and colloidal properties of bolaamphiphiles.” 2015. Masters Thesis, James Madison University. Accessed April 13, 2021. https://commons.lib.jmu.edu/honors201019/55.

MLA Handbook (7^th Edition):

Damiano, Louis M. “The synthesis and study of the biological and colloidal properties of bolaamphiphiles.” 2015. Web. 13 Apr 2021.

Vancouver:

Damiano LM. The synthesis and study of the biological and colloidal properties of bolaamphiphiles. [Internet] [Masters thesis]. James Madison University; 2015. [cited 2021 Apr 13]. Available from: https://commons.lib.jmu.edu/honors201019/55.

Council of Science Editors:

Damiano LM. The synthesis and study of the biological and colloidal properties of bolaamphiphiles. [Masters Thesis]. James Madison University; 2015. Available from: https://commons.lib.jmu.edu/honors201019/55

University of Kentucky

17. Tan, Xiao. DISCOVERY OF SELECTIVE PROBES TARGETING RNA POLYMERASE I.

Degree: 2019, University of Kentucky

URL: https://uknowledge.uky.edu/chemistry_etds/113

► RNR Polymerase I (RNA Pol I) is a “factory” that orchestrate the transcription of ribosomal rRNA for constructing ribosomes as a primary workshop for protein… (more)

Subjects/Keywords: RNA Polymerase I; Yeast; Cerivastatin Sodium; CX5461; YIPlac211-TG1; YBR140C; Chemicals and Drugs; Pharmaceutical Preparations

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APA (6^th Edition):

Tan, X. (2019). DISCOVERY OF SELECTIVE PROBES TARGETING RNA POLYMERASE I. (Masters Thesis). University of Kentucky. Retrieved from https://uknowledge.uky.edu/chemistry_etds/113

Chicago Manual of Style (16^th Edition):

Tan, Xiao. “DISCOVERY OF SELECTIVE PROBES TARGETING RNA POLYMERASE I.” 2019. Masters Thesis, University of Kentucky. Accessed April 13, 2021. https://uknowledge.uky.edu/chemistry_etds/113.

MLA Handbook (7^th Edition):

Tan, Xiao. “DISCOVERY OF SELECTIVE PROBES TARGETING RNA POLYMERASE I.” 2019. Web. 13 Apr 2021.

Vancouver:

Tan X. DISCOVERY OF SELECTIVE PROBES TARGETING RNA POLYMERASE I. [Internet] [Masters thesis]. University of Kentucky; 2019. [cited 2021 Apr 13]. Available from: https://uknowledge.uky.edu/chemistry_etds/113.

Council of Science Editors:

Tan X. DISCOVERY OF SELECTIVE PROBES TARGETING RNA POLYMERASE I. [Masters Thesis]. University of Kentucky; 2019. Available from: https://uknowledge.uky.edu/chemistry_etds/113

University of Iowa

18. Maney, Paul Vance. Dihydroxypropyl theophylline: its preparation and pharmacological and clinical study.

Degree: PhD, Pharmacy, 1945, University of Iowa

URL: https://ir.uiowa.edu/etd/6678

Subjects/Keywords: experimental pharmacology; Medicinal and Pharmaceutical Chemistry; Pharmaceutical Preparations

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APA (6^th Edition):

Maney, P. V. (1945). Dihydroxypropyl theophylline: its preparation and pharmacological and clinical study. (Doctoral Dissertation). University of Iowa. Retrieved from https://ir.uiowa.edu/etd/6678

Chicago Manual of Style (16^th Edition):

Maney, Paul Vance. “Dihydroxypropyl theophylline: its preparation and pharmacological and clinical study.” 1945. Doctoral Dissertation, University of Iowa. Accessed April 13, 2021. https://ir.uiowa.edu/etd/6678.

MLA Handbook (7^th Edition):

Maney, Paul Vance. “Dihydroxypropyl theophylline: its preparation and pharmacological and clinical study.” 1945. Web. 13 Apr 2021.

Vancouver:

Maney PV. Dihydroxypropyl theophylline: its preparation and pharmacological and clinical study. [Internet] [Doctoral dissertation]. University of Iowa; 1945. [cited 2021 Apr 13]. Available from: https://ir.uiowa.edu/etd/6678.

Council of Science Editors:

Maney PV. Dihydroxypropyl theophylline: its preparation and pharmacological and clinical study. [Doctoral Dissertation]. University of Iowa; 1945. Available from: https://ir.uiowa.edu/etd/6678

Bucknell University

19. Vostal, Kurt R. Stability of Amorphous Particles Formed via Monodisperse Droplet Evaporation.

Degree: 2018, Bucknell University

URL: https://digitalcommons.bucknell.edu/masters_theses/207

► Solid particle manufacturing processes in which size and internal structure are controlled are valuable to the development of effective products in the pharmaceutical, cosmetic, and… (more)

Subjects/Keywords: amorphous dispersion; phase transformation kinetics; pharmaceutical; polyvinylpyrrolidone; stability; crystallization; Chemical Engineering; Chemicals and Drugs; Pharmaceutical Preparations; Polymer Science; Thermodynamics

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APA (6^th Edition):

Vostal, K. R. (2018). Stability of Amorphous Particles Formed via Monodisperse Droplet Evaporation. (Thesis). Bucknell University. Retrieved from https://digitalcommons.bucknell.edu/masters_theses/207

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vostal, Kurt R. “Stability of Amorphous Particles Formed via Monodisperse Droplet Evaporation.” 2018. Thesis, Bucknell University. Accessed April 13, 2021. https://digitalcommons.bucknell.edu/masters_theses/207.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vostal, Kurt R. “Stability of Amorphous Particles Formed via Monodisperse Droplet Evaporation.” 2018. Web. 13 Apr 2021.

Vancouver:

Vostal KR. Stability of Amorphous Particles Formed via Monodisperse Droplet Evaporation. [Internet] [Thesis]. Bucknell University; 2018. [cited 2021 Apr 13]. Available from: https://digitalcommons.bucknell.edu/masters_theses/207.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vostal KR. Stability of Amorphous Particles Formed via Monodisperse Droplet Evaporation. [Thesis]. Bucknell University; 2018. Available from: https://digitalcommons.bucknell.edu/masters_theses/207

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Southern Cross University

20. Abiri, Armaghan. A critical analysis of the reform of the pharmaceutical sector in Iran, with specific reference to the regulatory framework.

Degree: 2018, Southern Cross University

URL: https://epubs.scu.edu.au/theses/598

► This thesis examines the theoretical and empirical case for reform of Iran’s pharmaceutical sector. It supports the view that a private pharmaceutical sector in Iran… (more)

Subjects/Keywords: Pharmaceutical industry; reform; regulatory system; responsive regulation; privatization; human rights; Iran; Food and Drug Law; Law; Legislation; Pharmaceutical Preparations

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Abiri, A. (2018). A critical analysis of the reform of the pharmaceutical sector in Iran, with specific reference to the regulatory framework. (Thesis). Southern Cross University. Retrieved from https://epubs.scu.edu.au/theses/598

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Abiri, Armaghan. “A critical analysis of the reform of the pharmaceutical sector in Iran, with specific reference to the regulatory framework.” 2018. Thesis, Southern Cross University. Accessed April 13, 2021. https://epubs.scu.edu.au/theses/598.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Abiri, Armaghan. “A critical analysis of the reform of the pharmaceutical sector in Iran, with specific reference to the regulatory framework.” 2018. Web. 13 Apr 2021.

Vancouver:

Abiri A. A critical analysis of the reform of the pharmaceutical sector in Iran, with specific reference to the regulatory framework. [Internet] [Thesis]. Southern Cross University; 2018. [cited 2021 Apr 13]. Available from: https://epubs.scu.edu.au/theses/598.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Abiri A. A critical analysis of the reform of the pharmaceutical sector in Iran, with specific reference to the regulatory framework. [Thesis]. Southern Cross University; 2018. Available from: https://epubs.scu.edu.au/theses/598

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Kentucky

21. Fugit, Kyle Daniel. QUANTIFICATION OF FACTORS GOVERNING DRUG RELEASE KINETICS FROM NANOPARTICLES: A COMBINED EXPERIMENTAL AND MECHANISTIC MODELING APPROACH.

Degree: 2014, University of Kentucky

URL: https://uknowledge.uky.edu/pharmacy_etds/37

► Advancements in nanoparticle drug delivery of anticancer agents require mathematical models capable of predicting in vivo formulation performance from in vitro characterization studies. Such models… (more)

▼ Advancements in nanoparticle drug delivery of anticancer agents require mathematical models capable of predicting in vivo formulation performance from in vitro characterization studies. Such models must identify and incorporate the physicochemical properties of the therapeutic agent and nanoparticle driving in vivo drug release. This work identifies these factors for two nanoparticle formulations of anticancer agents using an approach which develops mechanistic mathematical models in conjunction with experimental studies. A non-sink ultrafiltration method was developed to monitor liposomal release kinetics of the anticancer agent topotecan. Mathematical modeling allowed simultaneous determination of drug permeability and interfacial binding to the bilayer from release data. This method also quantified the effects of topotecan dimerization and surface potential on total amount of drug released from these liposomal formulations. The pH-sensitive release of topotecan from unilamellar vesicles was subsequently evaluated with this method. A mechanistic model identified three permeable species in which the zwitterionic lactone form of topotecan was the most permeable. Ring-closing kinetics of topotecan from its carboxylate to lactone form were found to be rate-limiting for topotecan drug release in the neutral pH region. Models were also developed to non-invasively analyze release kinetics of actively-loaded liposomal formulations of topotecan in vivo. The fluorescence excitation spectra of released topotecan were used to observe release kinetics in aqueous solution and human plasma. Simulations of the intravesicular pH in the various release media indicated accelerated release in plasma was a consequence of increased intravesicular pH due to ammonia levels in the plasma instead of alterations in bilayer integrity. Further studies were performed to understand the roles of dimerization, ion-pairing, and precipitation on loading and release kinetics obtained from actively-loaded topotecan. Extension of this type of modeling for other types of nanoparticles was illustrated with doxorubicin-conjugated polymeric micelles. Mathematical modeling of experimental studies monitoring doxorubicin release identified conjugation stability during storage, hydrazone hydrolysis kinetics, and unconjugated doxorubicin partitioning affected micellar doxorubicin release. This work identifies several of the key parameters governing drug release from these liposomal and micellar nanoparticles and lays the framework for future development of in vivo release models for these formulations.

Subjects/Keywords: Drug Release Kinetics; Liposomes; Micelles; Topotecan; Doxorubicin; Lipids; Medicinal and Pharmaceutical Chemistry; Medicinal-Pharmaceutical Chemistry; Oncology; Pharmaceutical Preparations; Pharmaceutics and Drug Design; Transport Phenomena

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fugit, K. D. (2014). QUANTIFICATION OF FACTORS GOVERNING DRUG RELEASE KINETICS FROM NANOPARTICLES: A COMBINED EXPERIMENTAL AND MECHANISTIC MODELING APPROACH. (Doctoral Dissertation). University of Kentucky. Retrieved from https://uknowledge.uky.edu/pharmacy_etds/37

Chicago Manual of Style (16^th Edition):

Fugit, Kyle Daniel. “QUANTIFICATION OF FACTORS GOVERNING DRUG RELEASE KINETICS FROM NANOPARTICLES: A COMBINED EXPERIMENTAL AND MECHANISTIC MODELING APPROACH.” 2014. Doctoral Dissertation, University of Kentucky. Accessed April 13, 2021. https://uknowledge.uky.edu/pharmacy_etds/37.

MLA Handbook (7^th Edition):

Fugit, Kyle Daniel. “QUANTIFICATION OF FACTORS GOVERNING DRUG RELEASE KINETICS FROM NANOPARTICLES: A COMBINED EXPERIMENTAL AND MECHANISTIC MODELING APPROACH.” 2014. Web. 13 Apr 2021.

Vancouver:

Fugit KD. QUANTIFICATION OF FACTORS GOVERNING DRUG RELEASE KINETICS FROM NANOPARTICLES: A COMBINED EXPERIMENTAL AND MECHANISTIC MODELING APPROACH. [Internet] [Doctoral dissertation]. University of Kentucky; 2014. [cited 2021 Apr 13]. Available from: https://uknowledge.uky.edu/pharmacy_etds/37.

Council of Science Editors:

Fugit KD. QUANTIFICATION OF FACTORS GOVERNING DRUG RELEASE KINETICS FROM NANOPARTICLES: A COMBINED EXPERIMENTAL AND MECHANISTIC MODELING APPROACH. [Doctoral Dissertation]. University of Kentucky; 2014. Available from: https://uknowledge.uky.edu/pharmacy_etds/37

22. Polonoff, Ethel S. In vitro metabolism of drug substrates by liver microsomal enzymes from male, pregnant and nonpregnant female rats.

Degree: MS, 1975, Oregon Health Sciences University

URL: doi:10.6083/M42805T1 ; http://digitalcommons.ohsu.edu/etd/2484

Subjects/Keywords: Pharmaceutical Preparations – metabolism; Phenytoin – metabolism; Microsomes, Liver – enzymology

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APA (6^th Edition):

Polonoff, E. S. (1975). In vitro metabolism of drug substrates by liver microsomal enzymes from male, pregnant and nonpregnant female rats. (Thesis). Oregon Health Sciences University. Retrieved from doi:10.6083/M42805T1 ; http://digitalcommons.ohsu.edu/etd/2484

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Polonoff, Ethel S. “In vitro metabolism of drug substrates by liver microsomal enzymes from male, pregnant and nonpregnant female rats.” 1975. Thesis, Oregon Health Sciences University. Accessed April 13, 2021. doi:10.6083/M42805T1 ; http://digitalcommons.ohsu.edu/etd/2484.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Polonoff, Ethel S. “In vitro metabolism of drug substrates by liver microsomal enzymes from male, pregnant and nonpregnant female rats.” 1975. Web. 13 Apr 2021.

Vancouver:

Polonoff ES. In vitro metabolism of drug substrates by liver microsomal enzymes from male, pregnant and nonpregnant female rats. [Internet] [Thesis]. Oregon Health Sciences University; 1975. [cited 2021 Apr 13]. Available from: doi:10.6083/M42805T1 ; http://digitalcommons.ohsu.edu/etd/2484.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Polonoff ES. In vitro metabolism of drug substrates by liver microsomal enzymes from male, pregnant and nonpregnant female rats. [Thesis]. Oregon Health Sciences University; 1975. Available from: doi:10.6083/M42805T1 ; http://digitalcommons.ohsu.edu/etd/2484

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Cai, Yufeng. Energetic and Dynamic Analysis of Inhibitor Binding to Drug-Resistant HIV-1 Proteases: A Dissertation.

Degree: Biochemistry and Molecular Pharmacology, Biochemistry and Molecular Pharmacology, 2009, U of Massachusetts : Med

URL: https://escholarship.umassmed.edu/gsbs_diss/448

► HIV-1 protease is a very important drug target for AIDS therapy. Nine protease inhibitors have been proved by FDA and used in AIDS treatment.… (more)

▼ HIV-1 protease is a very important drug target for AIDS therapy. Nine protease inhibitors have been proved by FDA and used in AIDS treatment. Due to the high replication rate and the lack of fidelity of the HIV-1 reverse transcriptase, HIV-1 virus developed various drug-resistant variants. Although experimental methods such as crystallography and isothermal titration calorimetry provide structural and thermodynamic data on drug-resistant variants, they are unable to discern the mechanism by which the mutations confer resistance to inhibitors. Understanding the drug-resistance mechanism is crucial for developing new inhibitors more tolerant to the drug-resistant mutations. Computational methods such as free energy calculations and molecular dynamic simulations can provide insights to the drug resistance mechanism at an atomic level. In this thesis, I have focused on the elucidation of the energetic and dynamics of key drug-resistant variants of HIV-1 protease. Two multi-drug resistant variants, in comparison with wild-type HIV-1 protease were used for the comparisons: Flap+ (L10I, G48V, I54V, and V82A) which contains a combination of flap and active site mutations and ACT (V82T, I84V) that only contains active site mutations. In Chapter II, I applied free energy simulations and decomposition methods to study the differential mechanism of resistance to the two variants, Flap+ and ACT, to the recently FDA-approved protease inhibitor darunavir (DRV). In this study, the absolute and relative binding free energies of DRV with wild-type protease and the two protease variants were calculated with MM-PB/GBSA and thermodynamic integration methods, respectively. And the predicted results are in good agreement with the ITC experimental results. Free energy decomposition elucidates the mutations alter not only its own interaction with DRV but also other residues by changing the geometry of binding pocket. And the VdW interactions between the bis-THF group of DRV is predominant even in the drug-resistant variants. At the end of this chapter, I offer suggestions on developing new inhibitors that are based on DRV but might be less susceptible to drug-resistant mutations. In Chapter III, 20-ns MD simulations of the apo wildtype protease and the apo drug-resistant protease variant Flap+ are analyzed and compared. In these studies, these mutations have been found to decrease the protease flexibility in the apo form but increase the mobility when the protease is binding with inhibitor. In Chapter IV, more details of the free energy simulation and decomposition are discussed. NMR relaxation experiments were set up as a control for the MD simulation study of the dynamics of the Flap+ variant. The difficulty of finishing the NMR experiment is discussed and the solution and some preliminary results are shown. In summary, the scope of this thesis was to use computational methods to study drug-resistant protease variants’ thermodynamic and dynamic properties to illuminate the mechanism of protease drug… Advisors/Committee Members: Celia A. Schiffer, Ph.D..

Subjects/Keywords: HIV Protease; HIV Protease Inhibitors; Drug Resistance; Viral; Genetic Phenomena; Immune System Diseases; Pharmaceutical Preparations; Therapeutics; Virus Diseases; Viruses

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APA (6^th Edition):

Cai, Y. (2009). Energetic and Dynamic Analysis of Inhibitor Binding to Drug-Resistant HIV-1 Proteases: A Dissertation. (Doctoral Dissertation). U of Massachusetts : Med. Retrieved from https://escholarship.umassmed.edu/gsbs_diss/448

Chicago Manual of Style (16^th Edition):

Cai, Yufeng. “Energetic and Dynamic Analysis of Inhibitor Binding to Drug-Resistant HIV-1 Proteases: A Dissertation.” 2009. Doctoral Dissertation, U of Massachusetts : Med. Accessed April 13, 2021. https://escholarship.umassmed.edu/gsbs_diss/448.

MLA Handbook (7^th Edition):

Cai, Yufeng. “Energetic and Dynamic Analysis of Inhibitor Binding to Drug-Resistant HIV-1 Proteases: A Dissertation.” 2009. Web. 13 Apr 2021.

Vancouver:

Cai Y. Energetic and Dynamic Analysis of Inhibitor Binding to Drug-Resistant HIV-1 Proteases: A Dissertation. [Internet] [Doctoral dissertation]. U of Massachusetts : Med; 2009. [cited 2021 Apr 13]. Available from: https://escholarship.umassmed.edu/gsbs_diss/448.

Council of Science Editors:

Cai Y. Energetic and Dynamic Analysis of Inhibitor Binding to Drug-Resistant HIV-1 Proteases: A Dissertation. [Doctoral Dissertation]. U of Massachusetts : Med; 2009. Available from: https://escholarship.umassmed.edu/gsbs_diss/448

Western Kentucky University

24. Hodzic, Denis. Effects of EF-24 and Cisplatin on Cancer, Renal, and Auditory Cells.

Degree: MS, Department of Biology, 2019, Western Kentucky University

URL: https://digitalcommons.wku.edu/theses/3110

► Cisplatin is a chemotherapy drug effective against several forms of cancer, but can also cause serious side-effects, including nephrotoxicity and ototoxicity. Curcumin, a natural… (more)

Subjects/Keywords: cisplatin; EF-24; cancer; ototoxicity; nephrotoxicity; Biochemistry, Biophysics, and Structural Biology; Biological Factors; Cancer Biology; Cell Biology; Pharmaceutical Preparations

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hodzic, D. (2019). Effects of EF-24 and Cisplatin on Cancer, Renal, and Auditory Cells. (Masters Thesis). Western Kentucky University. Retrieved from https://digitalcommons.wku.edu/theses/3110

Chicago Manual of Style (16^th Edition):

Hodzic, Denis. “Effects of EF-24 and Cisplatin on Cancer, Renal, and Auditory Cells.” 2019. Masters Thesis, Western Kentucky University. Accessed April 13, 2021. https://digitalcommons.wku.edu/theses/3110.

MLA Handbook (7^th Edition):

Hodzic, Denis. “Effects of EF-24 and Cisplatin on Cancer, Renal, and Auditory Cells.” 2019. Web. 13 Apr 2021.

Vancouver:

Hodzic D. Effects of EF-24 and Cisplatin on Cancer, Renal, and Auditory Cells. [Internet] [Masters thesis]. Western Kentucky University; 2019. [cited 2021 Apr 13]. Available from: https://digitalcommons.wku.edu/theses/3110.

Council of Science Editors:

Hodzic D. Effects of EF-24 and Cisplatin on Cancer, Renal, and Auditory Cells. [Masters Thesis]. Western Kentucky University; 2019. Available from: https://digitalcommons.wku.edu/theses/3110

Mykolas Romeris University

25. Balčiūnienė, Giedrė. Vaistinių veiklos teisinis reglamentavimas.

Degree: Master, Law, 2010, Mykolas Romeris University

URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20100224_101334-58857 ;

►

Šiame darbe nagrinėjama vaistinių veiklos teisinis reglamentavimas Lietuvoje racionalaus vaistinių preparatų vartojimo ir kokybiškos farmacinės paslaugos teikimo aspektu. Darbe analizuojami ir teisiniu požiūriu vertinami Lietuvos… (more)

▼

Šiame darbe nagrinėjama vaistinių veiklos teisinis reglamentavimas Lietuvoje racionalaus vaistinių preparatų vartojimo ir kokybiškos farmacinės paslaugos teikimo aspektu. Darbe analizuojami ir teisiniu požiūriu vertinami Lietuvos Respublikos teisės aktai, reglamentuojantys vaistinių veiklą bei vertinama farmacijos specialistų nuomonė apie tai, kokios teisės aktų nuostatos trukdo įgyvendinti šiuos tikslus. Darbas susideda iš trijų pagrindinių dalių. Pirmojoje darbo dalyje aiškinamas sąvokų vaistinių veiklos teisinis reglamentavimas, racionalus vaistinių preparatų vartojimas, farmacinė paslauga, farmacinė rūpyba, gera vaistinių praktika, vaistinių preparatų reklama, farmacinė informacija turinys, šių sąvokų samprata įvairių lietuvių ir užsienio autorių moksliniuose darbuose bei Lietuvos Respublikos teisės aktuose. Antrojoje darbo dalyje analizuojami pagrindiniai specialieji Lietuvos Respublikos vaistinių veiklą reglamentuojantys teisės aktai, identifikuojamos teisės aktų nuostatos, kurių įgyvendinimas neskatina racionalaus vaistinių preparatų vartojimo bei kokybiškos farmacinės paslaugos suteikimo. Trečiojoje šio darbo dalyje pateikiama anketinės apklausos būdu atlikto tyrimo rezultatų analizė. Remiantis teorinės analizės bei tyrimo metu gautais rezultatais, buvo suformuluotos ir pateiktos išvados ir rekomendacijos, kaip reikėtų tobulinti teisės aktus, kad būtų užtikrintas saugus ir racionalus vaistinių preparatų skyrimas ir vartojimas bei teikiama pilnavertė ir kokybiška... [toliau žr. visą tekstą]

This inquiry covers legal regulation of pharmacy practice in Lithuania paying extra attention to the aspect of rational use of medical preparations and providing high-quality pharmaceutical services. In this work there are analysed and estimated the Lithuanian legal acts regarding pharmaceutical enterprise as well as examine the barriers these acts provide on the way to achieving the goals stated as seen by the experts in the field. The work consists of three principal parts. In the first part there are defined the key concepts such as Legal Regulation of Pharmacy Practice, Rational Use of Medicine Preparations, Pharmaceutical Care, Good Pharmacy Practice, Advertisement of Medical Preparations and Pharmaceutical Information, their use in Lithuanian and international research studies and Lithuanian legal acts. The second part covers the analysis of specific pharmacy enterprise regulating legal acts, identifies the principles that do not encourage rational use of medical praparations and quality pharmaceutical services. Finally, the third part examines the study based on the results of the questionnaire presented to the active Lithuanian pharmaceutical experts. The study results enabled to construct and present certain conclussions and recommendations on how to improve the legal acts helping to ensure safe and rational administering and usage of medical preparations as well as to provide wholesome and high-quality pharmaceutical services corresponding to customer expectations.

Advisors/Committee Members: Balsienė, Janina (Master’s thesis supervisor), Juškevičus, Jonas (Master’s thesis advisor), Stakišaitis, Donatas (Master’s thesis reviewer), Juškevičius, Jonas (Master’s degree committee chair), Lapinskaitė , Genovaitė (Master’s degree committee member), Narbekovas, Andrius (Master’s degree committee member), Stakišaitis, Donatas (Master’s degree committee member), Širinskienė, Agnė (Master’s degree committee member).

Subjects/Keywords: Racionalus vaistinių preparatų vartojimas; Farmacinė paslauga; Gera vaistinių praktika; Rational use of medical preparations; Pharmaceutical service; Good pharmacy practice

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APA (6^th Edition):

Balčiūnienė, Giedrė. (2010). Vaistinių veiklos teisinis reglamentavimas. (Masters Thesis). Mykolas Romeris University. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20100224_101334-58857 ;

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Chicago Manual of Style (16^th Edition):

Balčiūnienė, Giedrė. “Vaistinių veiklos teisinis reglamentavimas.” 2010. Masters Thesis, Mykolas Romeris University. Accessed April 13, 2021. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20100224_101334-58857 ;.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

MLA Handbook (7^th Edition):

Balčiūnienė, Giedrė. “Vaistinių veiklos teisinis reglamentavimas.” 2010. Web. 13 Apr 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

Balčiūnienė, Giedrė. Vaistinių veiklos teisinis reglamentavimas. [Internet] [Masters thesis]. Mykolas Romeris University; 2010. [cited 2021 Apr 13]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20100224_101334-58857 ;.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Council of Science Editors:

Balčiūnienė, Giedrė. Vaistinių veiklos teisinis reglamentavimas. [Masters Thesis]. Mykolas Romeris University; 2010. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20100224_101334-58857 ;

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

University of Colorado

26. Russell, Elisabeth Emily. Monoclonal Antibody Aggregation in Cell Culture: Aggregate Characterization and Protein Stability Analysis.

Degree: PhD, Chemical & Biochemical Engineering, 2015, University of Colorado

URL: https://scholar.colorado.edu/chbe_gradetds/85

► Protein aggregates represent a safety, immunological and stability concern in therapeutic protein formulations. Aggregates may be formed at any stage during the manufacturing process,… (more)

Subjects/Keywords: aggregation; monoclonal antibody; protein; therapeutic; Amino Acids, Peptides, and Proteins; Biochemical and Biomolecular Engineering; Pharmaceutical Preparations

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Russell, E. E. (2015). Monoclonal Antibody Aggregation in Cell Culture: Aggregate Characterization and Protein Stability Analysis. (Doctoral Dissertation). University of Colorado. Retrieved from https://scholar.colorado.edu/chbe_gradetds/85

Chicago Manual of Style (16^th Edition):

Russell, Elisabeth Emily. “Monoclonal Antibody Aggregation in Cell Culture: Aggregate Characterization and Protein Stability Analysis.” 2015. Doctoral Dissertation, University of Colorado. Accessed April 13, 2021. https://scholar.colorado.edu/chbe_gradetds/85.

MLA Handbook (7^th Edition):

Russell, Elisabeth Emily. “Monoclonal Antibody Aggregation in Cell Culture: Aggregate Characterization and Protein Stability Analysis.” 2015. Web. 13 Apr 2021.

Vancouver:

Russell EE. Monoclonal Antibody Aggregation in Cell Culture: Aggregate Characterization and Protein Stability Analysis. [Internet] [Doctoral dissertation]. University of Colorado; 2015. [cited 2021 Apr 13]. Available from: https://scholar.colorado.edu/chbe_gradetds/85.

Council of Science Editors:

Russell EE. Monoclonal Antibody Aggregation in Cell Culture: Aggregate Characterization and Protein Stability Analysis. [Doctoral Dissertation]. University of Colorado; 2015. Available from: https://scholar.colorado.edu/chbe_gradetds/85

University of Debrecen

27. Alimohammadi, Shahrzad. Formulations and Investigations of vaginal and topical preparations agianst Candida Albicans infection .

Degree: DE – Gyógyszerésztudományi Kar, University of Debrecen

URL: http://hdl.handle.net/2437/213635

► The aim of my thesis was to develop new dosage forms of pharmaceutical preparations against C.Albicans such as Fluconazole vaginal suppository due to the lack… (more)

Subjects/Keywords: New preparations against Candida Albicans; Pharmaceutical technology

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APA (6^th Edition):

Alimohammadi, S. (n.d.). Formulations and Investigations of vaginal and topical preparations agianst Candida Albicans infection . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/213635

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Alimohammadi, Shahrzad. “Formulations and Investigations of vaginal and topical preparations agianst Candida Albicans infection .” Thesis, University of Debrecen. Accessed April 13, 2021. http://hdl.handle.net/2437/213635.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Alimohammadi, Shahrzad. “Formulations and Investigations of vaginal and topical preparations agianst Candida Albicans infection .” Web. 13 Apr 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Alimohammadi S. Formulations and Investigations of vaginal and topical preparations agianst Candida Albicans infection . [Internet] [Thesis]. University of Debrecen; [cited 2021 Apr 13]. Available from: http://hdl.handle.net/2437/213635.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Alimohammadi S. Formulations and Investigations of vaginal and topical preparations agianst Candida Albicans infection . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/213635

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

University of Florida

28. Weber, Dennis Joseph, 1934-. Stability constants and structures of metal complexes of the antithyroid thiouracils.

Degree: 1967, University of Florida

URL: https://ufdc.ufl.edu/AA00065690

Subjects/Keywords: Pharmaceutical Preparations – analysis ( mesh ); Antithyroid Agents ( mesh )

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APA (6^th Edition):

Weber, Dennis Joseph, 1. (1967). Stability constants and structures of metal complexes of the antithyroid thiouracils. (Thesis). University of Florida. Retrieved from https://ufdc.ufl.edu/AA00065690

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Weber, Dennis Joseph, 1934-. “Stability constants and structures of metal complexes of the antithyroid thiouracils.” 1967. Thesis, University of Florida. Accessed April 13, 2021. https://ufdc.ufl.edu/AA00065690.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Weber, Dennis Joseph, 1934-. “Stability constants and structures of metal complexes of the antithyroid thiouracils.” 1967. Web. 13 Apr 2021.

Vancouver:

Weber, Dennis Joseph 1. Stability constants and structures of metal complexes of the antithyroid thiouracils. [Internet] [Thesis]. University of Florida; 1967. [cited 2021 Apr 13]. Available from: https://ufdc.ufl.edu/AA00065690.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Weber, Dennis Joseph 1. Stability constants and structures of metal complexes of the antithyroid thiouracils. [Thesis]. University of Florida; 1967. Available from: https://ufdc.ufl.edu/AA00065690

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Kentucky

29. Lynch, Evan. Elucidating the Complex Signaling Events Driving Intestinal Stem Cell Plasticity Following Injury.

Degree: 2020, University of Kentucky

URL: https://uknowledge.uky.edu/microbio_etds/23

► Signaling events governing intestinal stem cell (ISC) homeostasis maintain the delicate balance of active self-renewal and passive differentiation to replenish intestinal epithelial cells (IEC) every… (more)

▼ Signaling events governing intestinal stem cell (ISC) homeostasis maintain the delicate balance of active self-renewal and passive differentiation to replenish intestinal epithelial cells (IEC) every 3-5 days. However, under certain contexts, ISC function is irreversibly compromised—requiring committed IEC lineages to dedifferentiate and regain “stemness”. In the current studies, we examine the signaling events driving epithelial cell responses to injury to expose pathologic failures in the healing response. Our specific goal is to tease out the cellular contexts that promote dedifferentiation to design effective therapeutics for disease conditions compromising ISC function. First, we generated a novel transgenic animal using the epithelial-specific Villin promoter to constitutively ablate the critical negative regulator in the Phosphotidyl-inositol 3 Kinase (PI3K) signaling pathway, p85α, in IECs. At baseline, removal of p85α led to increased activation of PI3K/Akt, as seen through elevations in phosphorylated PTEN, Akt, and GSK3β. The consequence of the persistent activation was a shifting of cells out of the stem cell niche, into more differentiated the proliferative progenitor pool, as seen by a decrease in Lgr5+ cells per crypt and an increase in Axin2+ transcripts by in situ hybridization. Further investigations revealed PI3K activation led to a bolstered secretory lineage, increased total number and size of Paneth cells within the crypt through reduced Notch signaling. Subsequent studies mechanistically clarify mitochondrial bioenergentics in p85-deficient epithelial cells demonstrate enhanced State III respiration to drive production of ROS. ROS activates p38-MAPK to mount observed differentiation pressure. Using whole-body irradiation to target ISCs, we revealed that p85-deficient crypts underwent restitution at a faster pace than their control counterparts. The consequence of the enhanced regeneration was an increased organism survival after lethal irradiation. Transcript flux revealed that p85-deficient crypts increased Wnt and PI3K signaling targets, specifically Lgr5, Axin2 and Survivin earlier in the regenerative process, suggesting the increased secretory progenitor pool could enact dedifferentiation mechanisms to replenish ISCs. Using human samples of radiation-induced intestinal injury, we demonstrate the requirement of Wnt-target Survivin protein expression in IEC survival, suggesting a conserved mechanism and possible avenue for future therapeutic intervention. Next, using isolated crypt epithelial cells from patients with inflammatory bowel disease (IBD), we establish that steroid-treated (prednisone) IBD patients harbor aberrant Wnt/β-catenin and NFκB signaling in IECs despite clinical improvement. At the molecular level, human IECs had significantly blunted cytosolic accumulation of Axin2 protein and subsequently decreased nuclear localization of downstream transcriptional activator, p-β-cateninSer552. Using a validated murine model of IBD, Dextran Sodium Sulfate-induced colitis (DSS colitis),…

Subjects/Keywords: Wnt; Intestinal Stem Cell; Inflammatory Bowel Disease; Metabolism; Radiation; Plasticity; Digestive System Diseases; Gastroenterology; Immune System Diseases; Pharmaceutical Preparations

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APA (6^th Edition):

Lynch, E. (2020). Elucidating the Complex Signaling Events Driving Intestinal Stem Cell Plasticity Following Injury. (Doctoral Dissertation). University of Kentucky. Retrieved from https://uknowledge.uky.edu/microbio_etds/23

Chicago Manual of Style (16^th Edition):

Lynch, Evan. “Elucidating the Complex Signaling Events Driving Intestinal Stem Cell Plasticity Following Injury.” 2020. Doctoral Dissertation, University of Kentucky. Accessed April 13, 2021. https://uknowledge.uky.edu/microbio_etds/23.

MLA Handbook (7^th Edition):

Lynch, Evan. “Elucidating the Complex Signaling Events Driving Intestinal Stem Cell Plasticity Following Injury.” 2020. Web. 13 Apr 2021.

Vancouver:

Lynch E. Elucidating the Complex Signaling Events Driving Intestinal Stem Cell Plasticity Following Injury. [Internet] [Doctoral dissertation]. University of Kentucky; 2020. [cited 2021 Apr 13]. Available from: https://uknowledge.uky.edu/microbio_etds/23.

Council of Science Editors:

Lynch E. Elucidating the Complex Signaling Events Driving Intestinal Stem Cell Plasticity Following Injury. [Doctoral Dissertation]. University of Kentucky; 2020. Available from: https://uknowledge.uky.edu/microbio_etds/23

30. Abdelwahab, Walid. USING DIFFERENT ANALYTICAL TECHNIQUES AND SYNTHETICALLY TAILORED SILICA NANOPARTICLES IN DRUG SEPARATIONS AND HYDROPHOBICITY-BASED DETECTION APPLICATIONS.

Degree: PhD, Chemistry, 2017, Georgia State University

URL: https://scholarworks.gsu.edu/chemistry_diss/140

► The development and validation of accurate and reliable analytical methods using techniques such as capillary electrophoresis, liquid chromatography, UV-spectrophotometry, spectrofluorimetry and mass spectrometry for… (more)

Subjects/Keywords: Separations; Liquid chromatography; Spectrometry; Capillary electrophoresis; Silica nanoparticles; Degradation kinetics; Pharmaceutical preparations; Fluorescent probes; Fingerprints detection; Haemocompatability studies

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Abdelwahab, W. (2017). USING DIFFERENT ANALYTICAL TECHNIQUES AND SYNTHETICALLY TAILORED SILICA NANOPARTICLES IN DRUG SEPARATIONS AND HYDROPHOBICITY-BASED DETECTION APPLICATIONS. (Doctoral Dissertation). Georgia State University. Retrieved from https://scholarworks.gsu.edu/chemistry_diss/140

Chicago Manual of Style (16^th Edition):

Abdelwahab, Walid. “USING DIFFERENT ANALYTICAL TECHNIQUES AND SYNTHETICALLY TAILORED SILICA NANOPARTICLES IN DRUG SEPARATIONS AND HYDROPHOBICITY-BASED DETECTION APPLICATIONS.” 2017. Doctoral Dissertation, Georgia State University. Accessed April 13, 2021. https://scholarworks.gsu.edu/chemistry_diss/140.

MLA Handbook (7^th Edition):

Abdelwahab, Walid. “USING DIFFERENT ANALYTICAL TECHNIQUES AND SYNTHETICALLY TAILORED SILICA NANOPARTICLES IN DRUG SEPARATIONS AND HYDROPHOBICITY-BASED DETECTION APPLICATIONS.” 2017. Web. 13 Apr 2021.

Vancouver:

Abdelwahab W. USING DIFFERENT ANALYTICAL TECHNIQUES AND SYNTHETICALLY TAILORED SILICA NANOPARTICLES IN DRUG SEPARATIONS AND HYDROPHOBICITY-BASED DETECTION APPLICATIONS. [Internet] [Doctoral dissertation]. Georgia State University; 2017. [cited 2021 Apr 13]. Available from: https://scholarworks.gsu.edu/chemistry_diss/140.

Council of Science Editors:

Abdelwahab W. USING DIFFERENT ANALYTICAL TECHNIQUES AND SYNTHETICALLY TAILORED SILICA NANOPARTICLES IN DRUG SEPARATIONS AND HYDROPHOBICITY-BASED DETECTION APPLICATIONS. [Doctoral Dissertation]. Georgia State University; 2017. Available from: https://scholarworks.gsu.edu/chemistry_diss/140

Open Access Theses and Dissertations