subject:(Peripheral artery disease)

University of Limerick

1. Cunnane, Eoghan M. Towards the development of guidelines for the endovascular treatment of peripheral artery disease: a tissue characterisation approach.

Degree: 2015, University of Limerick

URL: http://hdl.handle.net/10344/4794

►

peer-reviewed

The femoral arteries are one of the most susceptible vascular locations for the development of atherosclerosis. The occurrence of this disease process in these… (more)

▼

peer-reviewed

The femoral arteries are one of the most susceptible vascular locations for the development of atherosclerosis. The occurrence of this disease process in these vessels is the leading cause of lifestyle-limiting claudication and ischemic rest pain. Common femoral endarterectomy has been the standard treatment for focal occlusive disease of the femoral arteries for over 50 years. However, morbidity rates remain high due to its invasive nature and certain groups of patients are considered high risk for surgery. The use of Percutaneous Transluminal Angioplasty (PTA) has been advocated as a treatment alternative for patients at higher risk of surgical morbidity and mortality. Despite this, the long term results for PTA in the femoral arteries are disappointing due to uncontrolled dissections in complex lesions, inadequate luminal expansion in rigid strictures and recurrent stenosis in the dilated segment. PTA therefore requires procedural, technological, and suitable patient selection enhancements to function effectively as a treatment modality. Cutting Balloon Angioplasty (CBA) is an additional treatment alternative that employs a non-compliant balloon with radially positioned microblades to incise the plaque and propagate a controlled crack thereby reducing elastic recoil, vessel dilation, vessel injury, and subsequent restenosis. Preliminary reports have highlighted the possibility of CBA application in the peripheral arteries. However, various complications have also been reported including arterial rupture, delayed perforation and fracture of microsurgical blades. Arterial injury response to endovascular treatment varies significantly with plaque composition and it has been previously stated that the mechanisms of CBA affected by plaque composition need to be clarified. Therefore, a need exists to characterise the fracture behaviour of atherosclerotic femoral tissue and relate it to plaque biological content and structural morphology. Consequently, the research objective of this thesis is to enhance the implementation of endovascular treatments of the femoral arteries by presenting novel information regarding the characteristics of the target lesion. To achieve this, the mechanical properties and fracture behaviour of human atherosclerotic femoral tissue is characterised and related to plaque biological content and structural morphology. This will facilitate for more informed patient stratification, treatment approaches, and device design. A standardised uniaxial extension protocol is proposed and employed to characterise the mechanical behaviour of 20 endarterectomised femoral plaque samples in order to determine the tissue’s response to large circumferential deformation, the conditions induced during endovascular treatment. Guillotine testing is also employed to determine the Mode I fracture toughness of 30 sections from 5 endarterectomised femoral plaque samples to examine the tissue’s ability to resist crack propagation, the conditions induced specifically during CBA. This mechanical behaviour…

Advisors/Committee Members: Walsh, Michael T., Irish Government's Programme for Research in Third Level Institutions, IRC.

Subjects/Keywords: peripheral artery disease; plaque

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cunnane, E. M. (2015). Towards the development of guidelines for the endovascular treatment of peripheral artery disease: a tissue characterisation approach. (Thesis). University of Limerick. Retrieved from http://hdl.handle.net/10344/4794

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cunnane, Eoghan M. “Towards the development of guidelines for the endovascular treatment of peripheral artery disease: a tissue characterisation approach.” 2015. Thesis, University of Limerick. Accessed March 03, 2021. http://hdl.handle.net/10344/4794.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cunnane, Eoghan M. “Towards the development of guidelines for the endovascular treatment of peripheral artery disease: a tissue characterisation approach.” 2015. Web. 03 Mar 2021.

Vancouver:

Cunnane EM. Towards the development of guidelines for the endovascular treatment of peripheral artery disease: a tissue characterisation approach. [Internet] [Thesis]. University of Limerick; 2015. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/10344/4794.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cunnane EM. Towards the development of guidelines for the endovascular treatment of peripheral artery disease: a tissue characterisation approach. [Thesis]. University of Limerick; 2015. Available from: http://hdl.handle.net/10344/4794

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

2. Parvar, Saman Laleh. Major Adverse Cardiovascular Events and Mortality in Peripheral Artery Disease.

Degree: 2020, University of Adelaide

URL: http://hdl.handle.net/2440/127013

► Peripheral artery disease (PAD) is the third most prevalent atherosclerotic disorder after coronary artery and cerebrovascular disease. Irrespective of how it manifests clinically, PAD is… (more)

▼ Peripheral artery disease (PAD) is the third most prevalent atherosclerotic disorder after coronary artery and cerebrovascular disease. Irrespective of how it manifests clinically, PAD is consistently linked with excessive rates of major adverse cardiovascular events (MACE) and mortality. This thesis examines many contributing factors and provides new insights into the management of patients with this condition. The introductory chapter considers the evidence for treating individual risk factors and the prescription of guideline-recommended medications in PAD. Many prior observational studies have found an under-prescription of therapies and suboptimal risk factor control in PAD, compared with coronary artery disease-only. It is known from diabetes studies that control of multiple risk factors can have a complex interaction, whereby the sum of the parts does not equal the whole. Multiple risk factor control is recommended universally, although little is known regarding the effect on PAD. Chapter 2 is a post hoc analysis of the ACCELERATE trial that included 12,092 patients with atherosclerotic cardiovascular disease. The rates of MACE are compared between PAD and coronary artery disease-only patients in the setting of individual and combined risk factor control. It is believed that PAD patients have high-risk coronary artery plaque that is more critical, diffuse and prone to thrombotic occlusion, but this has not been proven. Chapter 3 pools data from three clinical trials of lipid-lowering therapy, whereby, coronary artery disease was monitored using serial intravascular ultrasound imaging. Plaque burden and disease progression are compared between PAD and non-PAD patients, according to risk factor control. Individual PAD studies indicate that there are gender discrepancies in symptoms, functional status, and treatment utilisation. It remains uncertain whether this translates to different long-term outcomes. Chapter 4 is a systematic review and meta-analysis to assess gender differences in MACE and mortality. Chapter 5 evaluates the gender differences in outcomes for the PAD patients from ACCELERATE. Lower extremity revascularisation, either through endovascular or surgical means, can be complicated by major adverse limb events and mortality. Persisting debate exists as to which approach has greater long-term durability and outcomes. Chapter 6 compares the long-term outcomes of endovascular and surgical revascularisation in unmatched and propensity-score matched groups. Dysfunctional high-density lipoprotein cholesterol (HDL-C) is an emerging cardiovascular risk factor that could be a therapeutic target. Previously, qualitative abnormalities of HDL-C were observed in Indigenous Australians, when they were compared to non-Indigenous Australians. Chapter 7 tests for an association between dysfunctional HDL and early PAD in Indigenous Australians. Significant health disparities are affecting young Indigenous Australians. The estimation of cardiovascular risk is especially problematic in this population. Chapter 8… Advisors/Committee Members: Nicholls, Stephen James (advisor), Fitridge, Robert (advisor), Dawson, Joseph (advisor), Adelaide Medical School (school).

Subjects/Keywords: Peripheral artery disease; mortality; cardiovascular disease

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Parvar, S. L. (2020). Major Adverse Cardiovascular Events and Mortality in Peripheral Artery Disease. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/127013

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Parvar, Saman Laleh. “Major Adverse Cardiovascular Events and Mortality in Peripheral Artery Disease.” 2020. Thesis, University of Adelaide. Accessed March 03, 2021. http://hdl.handle.net/2440/127013.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Parvar, Saman Laleh. “Major Adverse Cardiovascular Events and Mortality in Peripheral Artery Disease.” 2020. Web. 03 Mar 2021.

Vancouver:

Parvar SL. Major Adverse Cardiovascular Events and Mortality in Peripheral Artery Disease. [Internet] [Thesis]. University of Adelaide; 2020. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/2440/127013.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Parvar SL. Major Adverse Cardiovascular Events and Mortality in Peripheral Artery Disease. [Thesis]. University of Adelaide; 2020. Available from: http://hdl.handle.net/2440/127013

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

3. Nguyen, Cindy H. Comparing the Effectiveness of Cardiac Rehabilitation: Peripheral Artery Disease, Coronary Artery Disease, and Concomitant Disease.

Degree: 2018, University of Toronto

URL: http://hdl.handle.net/1807/91574

►

It is unclear if patients with PAD, CAD, and BOTH (PAD and CAD) differ in clinical profile, exercise prescription, and change in health outcomes at… (more)

Subjects/Keywords: cardiac rehabilitation; cardiorespiratory fitness; coronary artery disease; peripheral artery disease; 0566

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nguyen, C. H. (2018). Comparing the Effectiveness of Cardiac Rehabilitation: Peripheral Artery Disease, Coronary Artery Disease, and Concomitant Disease. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/91574

Chicago Manual of Style (16^th Edition):

Nguyen, Cindy H. “Comparing the Effectiveness of Cardiac Rehabilitation: Peripheral Artery Disease, Coronary Artery Disease, and Concomitant Disease.” 2018. Masters Thesis, University of Toronto. Accessed March 03, 2021. http://hdl.handle.net/1807/91574.

MLA Handbook (7^th Edition):

Nguyen, Cindy H. “Comparing the Effectiveness of Cardiac Rehabilitation: Peripheral Artery Disease, Coronary Artery Disease, and Concomitant Disease.” 2018. Web. 03 Mar 2021.

Vancouver:

Nguyen CH. Comparing the Effectiveness of Cardiac Rehabilitation: Peripheral Artery Disease, Coronary Artery Disease, and Concomitant Disease. [Internet] [Masters thesis]. University of Toronto; 2018. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/1807/91574.

Council of Science Editors:

Nguyen CH. Comparing the Effectiveness of Cardiac Rehabilitation: Peripheral Artery Disease, Coronary Artery Disease, and Concomitant Disease. [Masters Thesis]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/91574

University of Alberta

4. Sebastianski, Meghan K. Correlations Between Peripheral Artery Disease and Cardiovascular Disease Outcomes.

Degree: PhD, Department of Medicine, 2014, University of Alberta

URL: https://era.library.ualberta.ca/files/h415pb61t

► Lower-extremity peripheral artery disease (PAD) is a manifestation of atherosclerotic disease in the lower limbs. PAD is a risk factor for poor outcomes including myocardial… (more)

▼ Lower-extremity peripheral artery disease (PAD) is a manifestation of atherosclerotic disease in the lower limbs. PAD is a risk factor for poor outcomes including myocardial infarction, stroke, and mortality. Despite the potential benefits of early PAD detection, in the majority of PAD cases patients are asymptomatic, and as a result, PAD is underdiagnosed and undertreated. Furthermore, additional evidence is needed to clarify if PAD prevalence varies between ethnic groups. In short, the true burden of PAD is unknown. The main objective was to explore the prognostic relationship between PAD and outcomes in patients undergoing coronary angiography. Prospective collection of an ankle-brachial index (ABI), a non-invasive test with a high sensitivity and specificity for detecting PAD, was undertaken in 1100 patients. As ABI is often dichotomized for use in PAD detection and risk stratification, we examined continuous ABI as a risk marker and predictor of outcomes. We also undertook a systematic review of PAD prevalence studies and a cross-sectional analysis of cohort data to investigate the ethnic burden of PAD. Patients undergoing coronary angiography who have PAD (ABI ≤ 0.90) had 4.3 times more complex coronary artery disease (CAD) (adjusted OR 4.3, 95% CI 1.2, 14.9; p=0.022), 3.5 times more myocardium at risk (adjusted OR 3.5, 95% CI 1.7, 7.1; p=0.001), and less complete coronary revascularization (adjusted OR 3.0, 95% CI 1.1, 8.8; p=0.039) than patients with a normal ABI. At the other end of the ABI spectrum, there was no positive association between ABI > 1.40 and systolic inter-arm blood pressure difference (IAD) ≥ 10mmHg; rather there was a trend for a negative association (adjusted OR 0.3, 95% CI 0.1, 1.3; p=0.117). Differences in PAD prevalence were found in our systematic review where South Asians had significantly less PAD than White Europeans. Interestingly, no differences in PAD prevalence were found across six ethnic groups of patients undergoing hemodialysis. Our results support ABI use in screening and risk prediction in patients undergoing coronary angiography. More evidence is needed to determine the mechanisms for ethnic differences in PAD prevalence and further discussion of ABI is necessary to develop population appropriate guidelines.

Subjects/Keywords: Peripheral artery disease; Outcomes research; Cardiovascular disease; Atherosclerosis; Ankle-brachial index

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sebastianski, M. K. (2014). Correlations Between Peripheral Artery Disease and Cardiovascular Disease Outcomes. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/h415pb61t

Chicago Manual of Style (16^th Edition):

Sebastianski, Meghan K. “Correlations Between Peripheral Artery Disease and Cardiovascular Disease Outcomes.” 2014. Doctoral Dissertation, University of Alberta. Accessed March 03, 2021. https://era.library.ualberta.ca/files/h415pb61t.

MLA Handbook (7^th Edition):

Sebastianski, Meghan K. “Correlations Between Peripheral Artery Disease and Cardiovascular Disease Outcomes.” 2014. Web. 03 Mar 2021.

Vancouver:

Sebastianski MK. Correlations Between Peripheral Artery Disease and Cardiovascular Disease Outcomes. [Internet] [Doctoral dissertation]. University of Alberta; 2014. [cited 2021 Mar 03]. Available from: https://era.library.ualberta.ca/files/h415pb61t.

Council of Science Editors:

Sebastianski MK. Correlations Between Peripheral Artery Disease and Cardiovascular Disease Outcomes. [Doctoral Dissertation]. University of Alberta; 2014. Available from: https://era.library.ualberta.ca/files/h415pb61t

Georgia Tech

5. Johnson, Brandon Arthur Lucas. Isolation of angiogenic and arteriogenic subpopulations of peripheral blood CD31+ cells.

Degree: PhD, Biomedical Engineering (Joint GT/Emory Department), 2019, Georgia Tech

URL: http://hdl.handle.net/1853/62653

► Cardiovascular disease (CVD) is the leading cause of death in the world and is predicted to remain so. Vascular growth and regeneration is a critical… (more)

▼ Cardiovascular disease (CVD) is the leading cause of death in the world and is predicted to remain so. Vascular growth and regeneration is a critical process necessary to the successful recovery of ischemic cardiovascular injuries and diseases. Unfortunately, postnatal vascular growth is difficult to achieve especially in the case of geriatric individuals who are likely to suffer from multiple cardiovascular complications. Though several studies have investigated various neovasculogenic cell types, these cell are either rare, inconsistently isolated or their effectiveness and existence is controversial. Recently, circulating CD31+ cells were found to strongly increase vascular perfusion in animal models of limb ischemia; however, this cell population is heterogeneous and the mechanism of their neovasculogenic effects is not well understood. Our lab identified lineage marker CD14 as a means of separating CD31+ cells into angiogenic and arteriogenic fractions. This thesis uses a series of rigorous in vitro assays to characterize the phenotype of peripheral blood CD31+CD14+ and CD31+CD14- cells. Cytometric and RNA expression analyses reveal the representation of vascular repair lineages and upregulation of angiogenic genes among the CD31+CD14+ cells and an arteriogenic expression profile among CD31+CD14- cells. The observed phenotypes were further investigated using mouse models of limb ischemia. Histological analysis supports that transplanted PB-CD31+CD14+ cells rapidly induce capillary growth and angiogenesis while injected PB-CD31+CD14- cells increase smooth muscle cell recruitment and arteriogenesis. Overall, this work demonstrates the angiogenic and arteriogenic natures of circulating CD31+CD14+ and CD31+CD14- cells, respectively. This thesis also helps to uncover the mechanisms through which the less understood process of arteriogenesis occurs. These insights are significant for the further development of effective cell therapies for cardiovascular disease. Advisors/Committee Members: Yoon, Young-Sup (advisor), Garcia, Andres (committee member), Jun, Ho-Wook (committee member), Park, Changwon (committee member), Platt, Manu (committee member).

Subjects/Keywords: Ischemia; Peripheral artery disease; Peripheral blood; RNA-sequencing; Femoral artery ligation; CD31; Cardiovascular disease; Angiogenesis; Arteriogenesis; Neovasculogenesis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Johnson, B. A. L. (2019). Isolation of angiogenic and arteriogenic subpopulations of peripheral blood CD31+ cells. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/62653

Chicago Manual of Style (16^th Edition):

Johnson, Brandon Arthur Lucas. “Isolation of angiogenic and arteriogenic subpopulations of peripheral blood CD31+ cells.” 2019. Doctoral Dissertation, Georgia Tech. Accessed March 03, 2021. http://hdl.handle.net/1853/62653.

MLA Handbook (7^th Edition):

Johnson, Brandon Arthur Lucas. “Isolation of angiogenic and arteriogenic subpopulations of peripheral blood CD31+ cells.” 2019. Web. 03 Mar 2021.

Vancouver:

Johnson BAL. Isolation of angiogenic and arteriogenic subpopulations of peripheral blood CD31+ cells. [Internet] [Doctoral dissertation]. Georgia Tech; 2019. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/1853/62653.

Council of Science Editors:

Johnson BAL. Isolation of angiogenic and arteriogenic subpopulations of peripheral blood CD31+ cells. [Doctoral Dissertation]. Georgia Tech; 2019. Available from: http://hdl.handle.net/1853/62653

NSYSU

6. Chu, Chun-hsu. Analysis of the Effect and Medical Cost about Revascularization Procedure for Diabetic Foot.

Degree: Master, Institute of Health Care Management, 2013, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0124113-095137

► Abstract OBJECTIVEï¼Using the National Health Insurance research database, we investigated diabetic patients in Taiwan with peripheral artery occlusive disease. To see if revascularization procedures would… (more)

▼ Abstract OBJECTIVEï¼Using the National Health Insurance research database, we investigated diabetic patients in Taiwan with peripheral artery occlusive disease. To see if revascularization procedures would protect patients from major lower limb amputation. Also, we analyze the utilization of health care in admission. We expect that the results will be useful for the health administration to make a medical policy for these patients and more fully utilization of the National Health Insurance. METHODSï¼We used the National Health Insurance research database from the National Health Research Institute. We collected from the ambulatory care claim in the diabetic special topic files, the patients in 2002 who had been diagnosed with both diabetes and peripheral artery occlusive disease (PAOD). We followed up with these patients for 7 years (2002-2008). We collected the numbers of patients who had revascularization procedures, major lower limb amputation and inpatient claims. RESULTSï¼The total number of patients with diabetes and PAOD from 2002 ambulatory care claim was 1463. There were 213 patients with revascularization from the inpatient claims databases(2002-2008). 63(29.58%) of these 213 patients suffered from major lower limb amputation. There were 1250 patients without revascularization and 263(21.04%) of these patients suffered from major lower limb amputation. The revascularized patients had significant higher rates of major lower limb amputation than those without revascularization (p=0.006<0.05). No significant difference was noted of the length of the hospital stay between revascularized and non-revascularized patients(p=0.2258). There was significant difference of inpatient claims between revascularized and non-revascularized patients(p<0.05). The highest report of an inpatient claim occurred in the revascularized patients with major lower limb amputation(NT441,737). The 2nd highest one occurred in the revascularized patients without major lower limb amputation(NT216,372). The 3rd highest one occurred in the non-revascularized patients with major lower limb amputation(NT166,962). In the logistic regression analysis, revascularization and older age were significant predictors of major lower limb amputation (revascularization odds ratio 1.4279). CONCLUSION: Revascularization does not reduce the major lower limb amputation in these DM patients with PAOD. Because of limited medical resources, we should carefully consider applying the revascularization procedure for future patients. Keywordsï¼Diabetes, Peripheral artery occlusive disease, Revascularization, Major lower limb amputation Advisors/Committee Members: Shu-chuan Yeh (chair), Lee-wei Chen (chair), Ying-chun Li (committee member).

Subjects/Keywords: major lower limb amputation; revascularization; peripheral artery occlusive disease; diabetes

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chu, C. (2013). Analysis of the Effect and Medical Cost about Revascularization Procedure for Diabetic Foot. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0124113-095137

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chu, Chun-hsu. “Analysis of the Effect and Medical Cost about Revascularization Procedure for Diabetic Foot.” 2013. Thesis, NSYSU. Accessed March 03, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0124113-095137.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chu, Chun-hsu. “Analysis of the Effect and Medical Cost about Revascularization Procedure for Diabetic Foot.” 2013. Web. 03 Mar 2021.

Vancouver:

Chu C. Analysis of the Effect and Medical Cost about Revascularization Procedure for Diabetic Foot. [Internet] [Thesis]. NSYSU; 2013. [cited 2021 Mar 03]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0124113-095137.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chu C. Analysis of the Effect and Medical Cost about Revascularization Procedure for Diabetic Foot. [Thesis]. NSYSU; 2013. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0124113-095137

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vanderbilt University

7. Zachman, Angela Laurie. Peptide-functionalized Polymers Regulating Angiogenesis and Inflammation in Peripheral Artery Disease.

Degree: PhD, Biomedical Engineering, 2014, Vanderbilt University

URL: http://hdl.handle.net/1803/11870

► Peripheral artery disease (PAD) is characterized by platelet activation and aggregation on arterial walls, resulting in vessel occlusion and ischemia. To treat PAD, it is… (more)

Subjects/Keywords: inflammation; injectable polymer; atherosclerosis; peripheral artery disease; peptide; angiogenesis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zachman, A. L. (2014). Peptide-functionalized Polymers Regulating Angiogenesis and Inflammation in Peripheral Artery Disease. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/11870

Chicago Manual of Style (16^th Edition):

Zachman, Angela Laurie. “Peptide-functionalized Polymers Regulating Angiogenesis and Inflammation in Peripheral Artery Disease.” 2014. Doctoral Dissertation, Vanderbilt University. Accessed March 03, 2021. http://hdl.handle.net/1803/11870.

MLA Handbook (7^th Edition):

Zachman, Angela Laurie. “Peptide-functionalized Polymers Regulating Angiogenesis and Inflammation in Peripheral Artery Disease.” 2014. Web. 03 Mar 2021.

Vancouver:

Zachman AL. Peptide-functionalized Polymers Regulating Angiogenesis and Inflammation in Peripheral Artery Disease. [Internet] [Doctoral dissertation]. Vanderbilt University; 2014. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/1803/11870.

Council of Science Editors:

Zachman AL. Peptide-functionalized Polymers Regulating Angiogenesis and Inflammation in Peripheral Artery Disease. [Doctoral Dissertation]. Vanderbilt University; 2014. Available from: http://hdl.handle.net/1803/11870

University of Otago

8. Neale, Joshua Peter Howard. Ghrelin and peripheral artery disease .

Degree: University of Otago

URL: http://hdl.handle.net/10523/9384

► Peripheral artery disease (PAD) is the most common cardiovascular disease associated with type 2 diabetes mellitus (T2DM). PAD is characterised by the narrowing or occlusion… (more)

▼ Peripheral artery disease (PAD) is the most common cardiovascular disease associated with type 2 diabetes mellitus (T2DM). PAD is characterised by the narrowing or occlusion of systemic arteries impeding blood supply to the extremities. The prevalence of PAD is rapidly increasing because of the global T2DM pandemic and an ageing population. As PAD progresses to its most severe manifestation, termed critical limb ischaemia (CLI), surgical revascularisation becomes the preferred treatment option. Despite considerable advances in surgical revascularisation, up to 50% of patients with CLI are poor candidates for surgery or have failed revascularisation. Consequently, a large clinical cohort of patients is left with few viable treatment options Angiogenesis is the formation of new capillaries from the pre-existing vasculature. In therapeutic angiogenesis, attempts are made to enhance blood vessel growth and augment perfusion. Therapeutic angiogenesis has been studied as a treatment option for PAD for over two decades. However, no therapeutic agents have successfully transitioned from bench to bedside, and the development of therapeutic angiogenesis treatments remains a major clinical challenge. Ghrelin is a 28-amino acid peptide hormone most frequently studied in the context of energy homeostasis and metabolism. Emerging evidence suggests ghrelin may have a role in angiogenesis, making it a desirable agent for the treatment of PAD. However, what remains unknown is (1) the role of endogenous ghrelin in vascular homeostasis and its possible implications for PAD; (2) whether ghrelin induces therapeutic angiogenesis in an aged, T2DM murine model of PAD; and (3) what role endogenous ghrelin plays in humans with T2DM and non-diabetic PAD. To investigate this, two preclinical studies and one clinical study were conducted. The first preclinical study utilised global ghrelin knockout mice and unilateral hindlimb ischaemia as an in vivo preclinical PAD model. Following 14 days of ischaemia, ghrelin knockout mice had a delayed perfusion recovery. Microcomputer tomography and histological analysis revealed a failure to induce reparative revascularisation. Microangiography demonstrated an impaired endothelial function in knockout mice with hindlimb ischaemia, likely further exacerbating the perfusion recovery. Molecular analysis revealed that impaired revascularisation following injury was associated with the dysregulation of several microRNAs (miRNAs) associated with angiogenesis (miRNA -126 & -132). This preclinical study highlights the importance of endogenous ghrelin in vascular homoeostasis, shown by ghrelin knockout mice having an endogenous defect in perfusion recovery following hindlimb ischaemia. The second preclinical study investigated if exogenous ghrelin could induce therapeutic angiogenesis in an aged T2DM murine model of PAD. db/db mice were used as a murine model of T2DM and their non-diabetic db/+ littermates were used as controls. Unilateral hindlimb ischaemia was used as an in vivo preclinical PAD… Advisors/Committee Members: Katare, Rajesh (advisor).

Subjects/Keywords: Peripheral artery disease; Ghrelin; Angiogenesis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Neale, J. P. H. (n.d.). Ghrelin and peripheral artery disease . (Doctoral Dissertation). University of Otago. Retrieved from http://hdl.handle.net/10523/9384

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Chicago Manual of Style (16^th Edition):

Neale, Joshua Peter Howard. “Ghrelin and peripheral artery disease .” Doctoral Dissertation, University of Otago. Accessed March 03, 2021. http://hdl.handle.net/10523/9384.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

MLA Handbook (7^th Edition):

Neale, Joshua Peter Howard. “Ghrelin and peripheral artery disease .” Web. 03 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Neale JPH. Ghrelin and peripheral artery disease . [Internet] [Doctoral dissertation]. University of Otago; [cited 2021 Mar 03]. Available from: http://hdl.handle.net/10523/9384.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Council of Science Editors:

Neale JPH. Ghrelin and peripheral artery disease . [Doctoral Dissertation]. University of Otago; Available from: http://hdl.handle.net/10523/9384

Note: this citation may be lacking information needed for this citation format:
No year of publication.

University of Manitoba

9. Wang, Le. The effect of bean consumption on urinary and serum metabolites in patients with peripheral artery disease (PAD): a non-targeted metabolomics approach.

Degree: Human Nutritional Sciences, 2016, University of Manitoba

URL: http://hdl.handle.net/1993/31731

► Non-targeted liquid chromatography-mass spectrometry (LC-MS) based metabolomics methods were used to determine whether bean consumption affects the profile of metabolites in serum and urine of… (more)

Subjects/Keywords: Peripheral artery disease; Metabolomics; Bean consumption; LC-QTOF-MS

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, L. (2016). The effect of bean consumption on urinary and serum metabolites in patients with peripheral artery disease (PAD): a non-targeted metabolomics approach. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/31731

Chicago Manual of Style (16^th Edition):

Wang, Le. “The effect of bean consumption on urinary and serum metabolites in patients with peripheral artery disease (PAD): a non-targeted metabolomics approach.” 2016. Masters Thesis, University of Manitoba. Accessed March 03, 2021. http://hdl.handle.net/1993/31731.

MLA Handbook (7^th Edition):

Wang, Le. “The effect of bean consumption on urinary and serum metabolites in patients with peripheral artery disease (PAD): a non-targeted metabolomics approach.” 2016. Web. 03 Mar 2021.

Vancouver:

Wang L. The effect of bean consumption on urinary and serum metabolites in patients with peripheral artery disease (PAD): a non-targeted metabolomics approach. [Internet] [Masters thesis]. University of Manitoba; 2016. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/1993/31731.

Council of Science Editors:

Wang L. The effect of bean consumption on urinary and serum metabolites in patients with peripheral artery disease (PAD): a non-targeted metabolomics approach. [Masters Thesis]. University of Manitoba; 2016. Available from: http://hdl.handle.net/1993/31731

10. Gakhar, Neety. Dietary intake of peripheral artery disease patients.

Degree: Human Nutritional Sciences, 2013, University of Manitoba

URL: http://hdl.handle.net/1993/19448

► Peripheral artery disease (PAD) is one of the most common cardiovascular diseases. Despite high prevalence of PAD, data regarding the dietary patterns of Canadian individuals… (more)

Subjects/Keywords: Peripheral Artery Disease; Diet

…Peripheral artery disease CVD Cardiovascular diseases CHD Coronary heart disease ABI Ankle… …1.0. Introduction Peripheral artery disease (PAD) is a highly prevalent, silent… …development of coronary artery disease (CAD), cerebrovascular disease and PAD (15… …and Europe are affected by this disease. A total of 16.5 million PAD patients out of 27… …step towards the management of this highly prevalent and undertreated disease. The following…

2 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gakhar, N. (2013). Dietary intake of peripheral artery disease patients. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/19448

Chicago Manual of Style (16^th Edition):

Gakhar, Neety. “Dietary intake of peripheral artery disease patients.” 2013. Masters Thesis, University of Manitoba. Accessed March 03, 2021. http://hdl.handle.net/1993/19448.

MLA Handbook (7^th Edition):

Gakhar, Neety. “Dietary intake of peripheral artery disease patients.” 2013. Web. 03 Mar 2021.

Vancouver:

Gakhar N. Dietary intake of peripheral artery disease patients. [Internet] [Masters thesis]. University of Manitoba; 2013. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/1993/19448.

Council of Science Editors:

Gakhar N. Dietary intake of peripheral artery disease patients. [Masters Thesis]. University of Manitoba; 2013. Available from: http://hdl.handle.net/1993/19448

University of Minnesota

11. Brostow, Diana P. Body composition, nutrient intake and MTHFR genotype in patients with peripheral arterial disease.

Degree: P.D., Nutrition, 2014, University of Minnesota

URL: http://hdl.handle.net/11299/163656

► Background: Peripheral artery disease (PAD) is a progressive disease characterized by its impact on physical mobility, and a high rate of vascular comorbidities and events.… (more)

▼ Background: Peripheral artery disease (PAD) is a progressive disease characterized by its impact on physical mobility, and a high rate of vascular comorbidities and events. Despite its inclusion in the same grouping of conditions as cardiovascular (CVD) and cerebrovascular diseases, PAD garners much less attention, both in a clinical setting and in research. There is a significant body of research on the roles of nutrition and lifestyle in CVD and stroke etiology, yet the equivalent data for PAD is sparse. The impact of nutrition and related factors on PAD is poorly understood, and in need of expansive clarification.Methods: We conducted a literature review of all available research on nutrition and body composition in PAD, and used our assessments to design a cross-sectional study of these variables in a sample of PAD patients. We created a conceptual model of how nutrition-related variables may be associated with various aspects of PAD severity, and examined these associations within recruited participants.Results: Participants diets' were characterized by relatively high intakes of fat, sugar and sodium, as well as by low or inadequate intakes of crucial micronutrients. Several dietary factors were found to be significantly associated with more severe physical or psychosocial PAD symptoms. The majority of participants were also overweight or obese, and total body weight and abdominal obesity were associated with worse scores on tests of PAD severity. Additionally, we encountered several key obstacles to identifying and recruiting patients for this study. Conclusions: Although our sample size was relatively small, there is evidence to suggest that there are nutrition-related factors that are associated with the severity of PAD patients' symptoms and overall quality of life. Recruitment methods are in need of revision to obtain larger, more statistically powered samples, and we have outlined potential approaches for doing so. Lastly, this study establishes a precedent for future studies to implement interventions in PAD patients using already-established vascular guidelines for nutrition.

Subjects/Keywords: Atherosclerosis; Body composition; Nutrition; Obesity; Peripheral artery disease

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Brostow, D. P. (2014). Body composition, nutrient intake and MTHFR genotype in patients with peripheral arterial disease. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/163656

Chicago Manual of Style (16^th Edition):

Brostow, Diana P. “Body composition, nutrient intake and MTHFR genotype in patients with peripheral arterial disease.” 2014. Doctoral Dissertation, University of Minnesota. Accessed March 03, 2021. http://hdl.handle.net/11299/163656.

MLA Handbook (7^th Edition):

Brostow, Diana P. “Body composition, nutrient intake and MTHFR genotype in patients with peripheral arterial disease.” 2014. Web. 03 Mar 2021.

Vancouver:

Brostow DP. Body composition, nutrient intake and MTHFR genotype in patients with peripheral arterial disease. [Internet] [Doctoral dissertation]. University of Minnesota; 2014. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/11299/163656.

Council of Science Editors:

Brostow DP. Body composition, nutrient intake and MTHFR genotype in patients with peripheral arterial disease. [Doctoral Dissertation]. University of Minnesota; 2014. Available from: http://hdl.handle.net/11299/163656

University of Minnesota

12. Salisbury, Dereck Lee. The effects of two modes of exercise training on plasma biomarkers of inflammation and oxidative stress in patients with symptomatic peripheral artery disease.

Degree: PhD, Kinesiology, 2014, University of Minnesota

URL: http://hdl.handle.net/11299/167459

► Introduction: Peripheral Artery Disease (PAD) is a manifestation of progressive atherosclerosis involving the main conduit arteries supplying the lower extremities. It is well known that… (more)

▼ Introduction: Peripheral Artery Disease (PAD) is a manifestation of progressive atherosclerosis involving the main conduit arteries supplying the lower extremities. It is well known that atherosclerotic cardiovascular disease including PAD, is related partly to vascular inflammation and oxidative stress. Treadmill walking exercise to moderate claudication pain is considered the gold standard for improving walking distance in patients with PAD and claudication. Our group had previously reported that non-ischemia inducing upper body ergometry exercise training improves pain-free and maximal walking distance similar to ischemic inducing treadmill exercise training in patients with claudication. The influence of ischemic and non-ischemic inducing exercise training on systemic inflammation and vascular oxidative stress remains to be fully elucidated. Methods: A total of 75 patients (59 male and 16 female) with symptomatic PAD from the randomized controlled trial, Exercise Training to Reduce Claudication (EXERT), were used in a secondary analysis of inflammation and oxidative stress. Analysis of plasma for TNF alpha, IL-10, and F2 Isoprostane were performed at baseline and following 12 weeks of moderate intensity, claudication inducing treadmill training (T), upper body ergometry training (UBE), or usual care (C). Analysis of covariance was used to evaluate changes among groups for all biomarkers following intervention, using baseline level as a covariate. Pearson's correlation coefficient was used to assess correlation among baseline plasma biomarkers and physical and physiological variables. Results: After 12 weeks of intervention, all patients, regardless of the group increased TNF alpha levels. In particular, patients randomized to the UBE group significantly increased TNF alpha levels compared to the control group after adjusting for baseline TNF alpha and allopurinol (a significant covariate). Participants in the treadmill group had non-significant increases in IL-10, while all groups showed non-significant decreases in F2 Isoprostanes. Additionally there was no significant correlation between baseline plasma inflammatory and oxidative stress biomarkers, with physical and physiological variables such as ankle-brachial index, pain-free walking distance, and maximal walking distance at baseline. However, body mass index was significantly correlated to baseline TNF alpha levels (r=0.228, p=0.05). Conclusion: Moderate intensity UBE training appears to significantly increase the proinflammatory cytokine TNF alpha compared to a control group in patients with symptomatic PAD. However, all groups increased TNF alpha after 12 weeks of intervention, which contradicts the deemed anti-inflammatory effect of aerobic exercise training. It is clear that further study is required to establish if exercise training in patients with claudication is anti-inflammatory.

Subjects/Keywords: Exercise; Inflammation; Oxidative stress; Peripheral artery disease; Kinesiology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Salisbury, D. L. (2014). The effects of two modes of exercise training on plasma biomarkers of inflammation and oxidative stress in patients with symptomatic peripheral artery disease. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/167459

Chicago Manual of Style (16^th Edition):

Salisbury, Dereck Lee. “The effects of two modes of exercise training on plasma biomarkers of inflammation and oxidative stress in patients with symptomatic peripheral artery disease.” 2014. Doctoral Dissertation, University of Minnesota. Accessed March 03, 2021. http://hdl.handle.net/11299/167459.

MLA Handbook (7^th Edition):

Salisbury, Dereck Lee. “The effects of two modes of exercise training on plasma biomarkers of inflammation and oxidative stress in patients with symptomatic peripheral artery disease.” 2014. Web. 03 Mar 2021.

Vancouver:

Salisbury DL. The effects of two modes of exercise training on plasma biomarkers of inflammation and oxidative stress in patients with symptomatic peripheral artery disease. [Internet] [Doctoral dissertation]. University of Minnesota; 2014. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/11299/167459.

Council of Science Editors:

Salisbury DL. The effects of two modes of exercise training on plasma biomarkers of inflammation and oxidative stress in patients with symptomatic peripheral artery disease. [Doctoral Dissertation]. University of Minnesota; 2014. Available from: http://hdl.handle.net/11299/167459

Kansas State University

13. Kempf, Evan Alexander. Chronic femoral artery ligation exaggerates the pressor and sympathetic nerve responses during dynamic skeletal muscle stretch in decerebrate rats.

Degree: MS, Department of Kinesiology, 2017, Kansas State University

URL: http://hdl.handle.net/2097/38193

► Mechanical and metabolic signals arising during skeletal muscle contraction reflexly increase sympathetic nerve activity and blood pressure (i.e., the exercise pressor reflex). In a rat… (more)

Subjects/Keywords: Exercise; Ischemia; Blood pressure; Muscle afferents; Peripheral artery disease

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kempf, E. A. (2017). Chronic femoral artery ligation exaggerates the pressor and sympathetic nerve responses during dynamic skeletal muscle stretch in decerebrate rats. (Masters Thesis). Kansas State University. Retrieved from http://hdl.handle.net/2097/38193

Chicago Manual of Style (16^th Edition):

Kempf, Evan Alexander. “Chronic femoral artery ligation exaggerates the pressor and sympathetic nerve responses during dynamic skeletal muscle stretch in decerebrate rats.” 2017. Masters Thesis, Kansas State University. Accessed March 03, 2021. http://hdl.handle.net/2097/38193.

MLA Handbook (7^th Edition):

Kempf, Evan Alexander. “Chronic femoral artery ligation exaggerates the pressor and sympathetic nerve responses during dynamic skeletal muscle stretch in decerebrate rats.” 2017. Web. 03 Mar 2021.

Vancouver:

Kempf EA. Chronic femoral artery ligation exaggerates the pressor and sympathetic nerve responses during dynamic skeletal muscle stretch in decerebrate rats. [Internet] [Masters thesis]. Kansas State University; 2017. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/2097/38193.

Council of Science Editors:

Kempf EA. Chronic femoral artery ligation exaggerates the pressor and sympathetic nerve responses during dynamic skeletal muscle stretch in decerebrate rats. [Masters Thesis]. Kansas State University; 2017. Available from: http://hdl.handle.net/2097/38193

York University

14. Ikediashi Nwadozi, Emmanuel. Molecular Coordination of Skeletal Muscle Capillary Remodeling in Obesity: Implications for Metabolic Homeostasis and Disease.

Degree: PhD, Kinesiology & Health Science, 2020, York University

URL: http://hdl.handle.net/10315/37763

► Considerable effort has been directed towards the development of preventative and therapeutic strategies against obesity and its clinical sequalae that now pose a significant public… (more)

▼ Considerable effort has been directed towards the development of preventative and therapeutic strategies against obesity and its clinical sequalae that now pose a significant public health and economic burden on healthcare systems worldwide. The skeletal muscle capillary network has emerged as a critical determinant of metabolic homeostasis and structural remodelling of this network is now widely accepted to contribute to the pathogenesis of obesity. However, the regulation of skeletal muscle capillary remodelling in obesity remains controversial and largely unexplored. The purpose of the current dissertation was to define intrinsic molecular mechanisms that govern these skeletal muscle capillary remodelling responses in obesity. Administration of a 16-week high-fat (HF) diet was associated with and expansion (angiogenesis) of the skeletal muscle capillary network and promoted the expression of pro-angiogenic factors including leptin and vascular endothelial growth factor-A (VEGF-A). To investigate the potential involvement of anti-angiogenic factors in mediating the capillary remodelling response in obesity, I investigated the role of forkhead box O (FoxO) transcription factors that are potent repressors of skeletal muscle angiogenesis and have previously been implicated in the progression of metabolic disorders. In transgenic mice that have an endothelial cell directed depletion of FoxO proteins (Foxo mice), I demonstrated enhanced angiogenesis after 16-weeks of HF diet, which was associated with the preservation of peripheral insulin sensitivity. Together, these findings demonstrated that angiogenesis is a physiological adaptation to obesity that is governed by the net-influence of pro- and anti-angiogenic molecular factors. Finally, to determine whether the positive influence of obesity on the skeletal muscle capillary network was beneficial in a pathological context, HF-preconditioned mice were subjected to a pre-clinical model of peripheral artery disease, a condition characterized by reduced blood flow (ischemia) to the lower limbs. HF-preconditioning elicited an overall increase in capillary perfusion, which was associated with enhanced microvascular remodelling, blood flow recovery and tissue regeneration following the onset of ischemia, highlighting the potential benefit of vasculo-centric therapies against the clinical progression of obesity. Overall, these findings demonstrate that angiogenesis is a physiological adaptation that preserves metabolic homeostasis and provides mechanistic insight into the coordination of skeletal muscle capillary in obesity. Advisors/Committee Members: Roudier, Emilie (advisor), Haas, Tara (advisor).

Subjects/Keywords: Physiology; Obesity; Skeletal Muscle; Capillary; Angiogenesis; Peripheral Artery Disease

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ikediashi Nwadozi, E. (2020). Molecular Coordination of Skeletal Muscle Capillary Remodeling in Obesity: Implications for Metabolic Homeostasis and Disease. (Doctoral Dissertation). York University. Retrieved from http://hdl.handle.net/10315/37763

Chicago Manual of Style (16^th Edition):

Ikediashi Nwadozi, Emmanuel. “Molecular Coordination of Skeletal Muscle Capillary Remodeling in Obesity: Implications for Metabolic Homeostasis and Disease.” 2020. Doctoral Dissertation, York University. Accessed March 03, 2021. http://hdl.handle.net/10315/37763.

MLA Handbook (7^th Edition):

Ikediashi Nwadozi, Emmanuel. “Molecular Coordination of Skeletal Muscle Capillary Remodeling in Obesity: Implications for Metabolic Homeostasis and Disease.” 2020. Web. 03 Mar 2021.

Vancouver:

Ikediashi Nwadozi E. Molecular Coordination of Skeletal Muscle Capillary Remodeling in Obesity: Implications for Metabolic Homeostasis and Disease. [Internet] [Doctoral dissertation]. York University; 2020. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/10315/37763.

Council of Science Editors:

Ikediashi Nwadozi E. Molecular Coordination of Skeletal Muscle Capillary Remodeling in Obesity: Implications for Metabolic Homeostasis and Disease. [Doctoral Dissertation]. York University; 2020. Available from: http://hdl.handle.net/10315/37763

NSYSU

15. Yang, Ching-ping. The Prevalence and Clinical Correlative Factors of Peripheral Arterial Disease in Patients with Chronic Kidney Disease.

Degree: Master, Institute of Health Care Management, 2009, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0617109-120417

► Research Objective Patients with chronic kidney disease (CKD) are at increased risk for atherosclerosis and peripheral artery disease (PAD). PAD has received far less attention… (more)

▼ Research Objective Patients with chronic kidney disease (CKD) are at increased risk for atherosclerosis and peripheral artery disease (PAD). PAD has received far less attention than coronary artery disease (CAD) in CKD patients. Few studies have examined risk factors for PAD in CKD. We studied the possible related risk factors and benefit of hypertension treatment in CKD patients with PAD. Data Sources We included 129 patients of both sexes with stages 3 to 5 of CKD, as described by the Kidney Outcome Quality Initiatives (K/DOQI ) classification, without receiving dialysis therapy, not previously diagnosed with PAD. Study Design The following information were collected within six month period, including demographic characteristics, history of hypertension, anti-hypertension drug, diabetes, smoking, and pre-existing cardiovascular disease, body mass index (BMI), fasting blood glucose, HbA1c, total cholesterol, triglyceride(TG), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol(LDL), calcium (Ca), phosphate(P), Albumin, uric acid, urine protein. Ankle-brachial index (ABI) is a noninvasive diagnostic test that is efficient in detecting asymptomatic PAD with ABI <0.9. Findings There were 22 (17.7 %) participants with PAD. Higher systolic blood pressure (SBP), higher diastolic blood pressure (DBP), higher pulse pressure showed strong association with PAD in CKD patients. On further analysis, significant fewer patients treated with calcium channel blocker (CCB) in hypertensive CKD patients with PAD (Ï2 =7.055, p =0.008). The multivariate logistic regression analysis in hypertensive patients demonstrated the risk factors for PAD was pulse pressure, and Calcium channel blocker treatment may correlate with decreasing PAD formation (odds ratio= 0.232, 95% CI=0.07-0.73, p =0.013) in CKD patients. Conclusion There is a high prevalence rate of PAD in population of CKD, especially those with hypertension. ABI should be routinely examined in these patients who can benefit earlier from therapeutic measures. Advisors/Committee Members: Ying-chun Li (chair), Shu-chuan Jennifer Yeh (committee member), Meng-chiao Lin (chair).

Subjects/Keywords: Ankle brachial index; Chronic kidney disease; Calcium channel blocker; Pulse pressure; hypertension; Peripheral artery disease

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yang, C. (2009). The Prevalence and Clinical Correlative Factors of Peripheral Arterial Disease in Patients with Chronic Kidney Disease. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0617109-120417

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yang, Ching-ping. “The Prevalence and Clinical Correlative Factors of Peripheral Arterial Disease in Patients with Chronic Kidney Disease.” 2009. Thesis, NSYSU. Accessed March 03, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0617109-120417.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yang, Ching-ping. “The Prevalence and Clinical Correlative Factors of Peripheral Arterial Disease in Patients with Chronic Kidney Disease.” 2009. Web. 03 Mar 2021.

Vancouver:

Yang C. The Prevalence and Clinical Correlative Factors of Peripheral Arterial Disease in Patients with Chronic Kidney Disease. [Internet] [Thesis]. NSYSU; 2009. [cited 2021 Mar 03]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0617109-120417.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yang C. The Prevalence and Clinical Correlative Factors of Peripheral Arterial Disease in Patients with Chronic Kidney Disease. [Thesis]. NSYSU; 2009. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0617109-120417

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Sydney

16. Monaro, Susan Rita. Grappling with decisions about amputation for critical limb ischaemia: the patient and family experience .

Degree: 2018, University of Sydney

URL: http://hdl.handle.net/2123/20199

► Major amputation may be advised for patients with Critical Limb Ischaemia (CLI), a devastating endpoint of lower extremity arterial disease. Making a decision about amputation… (more)

▼ Major amputation may be advised for patients with Critical Limb Ischaemia (CLI), a devastating endpoint of lower extremity arterial disease. Making a decision about amputation is difficult; while the clinical outcomes of these amputations are well researched, little is known about the patient and family experience of making such a decision. Making an earlier decision for amputation may improve person and family outcomes as patients often deteriorate rapidly, resulting in them having to face and emerge from amputation with increased frailty and morbidity, greater mortality risk and protracted recovery. This study aimed to provide a deeper understanding of the person and family experience of CLI and the making of decisions about amputation. This longitudinal qualitative study engaged 14 people with CLI and 13 family members to explore 19 CLI journeys. People proceeding to amputation were interviewed pre- and six-months post-amputation, while people declining amputation were interviewed once. Forty-two verbatim transcripts were analysed using hermeneutic phenomenology, underpinned by the existential philosophies of Heidegger and Merleau-Ponty to explore embodied CLI, Being-towards-death, Being-with others, and either turning towards or turning away from, amputation. The qualitative interpretation centred around Heidegger’s authentic and inauthentic ‘modes of Being’. For Heidegger, authenticity of being is a shift in attention and engagement to focus upon one’s uniquely individual or true self, turning away from the inauthentic everyday world of the ‘they’ (Das Mann) where Dasein usually resides. In moments of authenticity, Dasein experiences clarity of self, a sense of meaningful existence, and of being its own. In contrast, in inauthenticity, beings are ‘sucked into the turbulence of the world of ‘they’’, becoming lost or separated from their sense of unique identity and purpose. When decisions about amputation were grappled with, CLI patients demonstrated a tendency to dwell in a state of inauthentic being, obscuring their unique possibilities for existence. Retreating from discourse and neglecting or renouncing decisions contributed to difficulties in shaping and timing intentions for the body with CLI and participants initially gravitated towards conservative care. Where there was authentic clinician presence and people with CLI engaged in discourse about amputation, they reached a clearing of understanding where they could authentically position themselves to make their ‘right’ decision. The findings supported the need for earlier and enhanced clinician facilitation of patient and family decision-making about CLI-related amputation. Ideally, amputation needs to be considered not as a treatment failure but as a valid palliative option that provides effective symptom control for the frequently unendurable pain of CLI.

Subjects/Keywords: peripheral artery disease; peripheral arterial disease; critical limb ischaemia; amputation; decision making; phenomenology; qualitative; patient experience; family experience

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Monaro, S. R. (2018). Grappling with decisions about amputation for critical limb ischaemia: the patient and family experience . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/20199

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Monaro, Susan Rita. “Grappling with decisions about amputation for critical limb ischaemia: the patient and family experience .” 2018. Thesis, University of Sydney. Accessed March 03, 2021. http://hdl.handle.net/2123/20199.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Monaro, Susan Rita. “Grappling with decisions about amputation for critical limb ischaemia: the patient and family experience .” 2018. Web. 03 Mar 2021.

Vancouver:

Monaro SR. Grappling with decisions about amputation for critical limb ischaemia: the patient and family experience . [Internet] [Thesis]. University of Sydney; 2018. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/2123/20199.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Monaro SR. Grappling with decisions about amputation for critical limb ischaemia: the patient and family experience . [Thesis]. University of Sydney; 2018. Available from: http://hdl.handle.net/2123/20199

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

17. Tseng , Shih-Ya. Cilostazol increases proangiogeneic functions of human early endothelial progenitor cells and hybrid therapy provides a synergistic treatment effect to hindlimb ischemia animal model.

Degree: PhD, Biological Sciences, 2017, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0216117-100714

► Critical limb ischemia (CLI) is an advanced form of peripheral artery disease in which the narrowing arteries limit blood supply to the lower extremities with… (more)

▼ Critical limb ischemia (CLI) is an advanced form of peripheral artery disease in which the narrowing arteries limit blood supply to the lower extremities with resultant of resting pain and eventually, tissue loss. At present time, it is likely that proangiogenic stem cell therapy is anticipated as a promising therapeutic strategy in patients with CLI. However, a potential limitation of autologous cell therapy is that the insufficient number of stem cells were available the patients who may also suffer other problems. Therefore, how to generate enough autologous stem cells in vitro for future implantation application has become a major issue. Cilostazol is used as a vasodilating and anti-platelet aggregation drug clinically by increasing intracellular levels of cAMP. Our recent works and other reports have suggested that cilostazol may promote angiogenesis. Unfortunately, the effects of cilostazol on growth and differentiation of human early endothelial progenitor cells (EPCs) remain mostly unclear. In the current work, we explored the novel angiogenic effects of cilostazol on EPCs by using both in vitro and in vivo models. We found that human early EPCs treated with cilostazol significantly increase colony-forming units and enhanced differentiation of EPCs toward endothelial lineage. It was not only stimulated proliferation, migration, anti-apoptosis effect but also in vitro vascular tube formation through activation of SDF-1Î± /CXCR4/PI3K/Akt signaling pathway. In addition, Matrigel plug assay and mouse hind limb ischemia model also demonstrated that administration of a concomitant therapy with cilostazol and EPCs-treated mice were in vessel maturation higher, capillary significantly density and blood flow recovery, in comparison with either treatment alone. These results indicated that co-administration of cilostazol reinforced the autocrine effect of transplanted human early EPCs to provide a synergistic effect in angiogenesis through activation of SDF-1 Î±/CXCR4/PI3K/Akt signaling pathway. In clinical Implication, cilostazol plus EPCs treatment may be beneficial in improving EPC transplantation efficacy and enhancing vascular re-endothelialization in patients with critical limb ischemia. Advisors/Committee Members: Wang, Hay-Yan (chair), Wang, Yang-Kao (chair), Cho, Chung-Lung (committee member), Chen, Chun-Lin (chair), Chao, Ting-Hsing (committee member), Li, Yi-Heng (chair).

Subjects/Keywords: Peripheral artery disease; Critical limb ischemia; Angiogenesis; Cilostazol; SDF-1Î±; Endothelial progenitor cells

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tseng , S. (2017). Cilostazol increases proangiogeneic functions of human early endothelial progenitor cells and hybrid therapy provides a synergistic treatment effect to hindlimb ischemia animal model. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0216117-100714

Chicago Manual of Style (16^th Edition):

Tseng , Shih-Ya. “Cilostazol increases proangiogeneic functions of human early endothelial progenitor cells and hybrid therapy provides a synergistic treatment effect to hindlimb ischemia animal model.” 2017. Doctoral Dissertation, NSYSU. Accessed March 03, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0216117-100714.

MLA Handbook (7^th Edition):

Tseng , Shih-Ya. “Cilostazol increases proangiogeneic functions of human early endothelial progenitor cells and hybrid therapy provides a synergistic treatment effect to hindlimb ischemia animal model.” 2017. Web. 03 Mar 2021.

Vancouver:

Tseng S. Cilostazol increases proangiogeneic functions of human early endothelial progenitor cells and hybrid therapy provides a synergistic treatment effect to hindlimb ischemia animal model. [Internet] [Doctoral dissertation]. NSYSU; 2017. [cited 2021 Mar 03]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0216117-100714.

Council of Science Editors:

Tseng S. Cilostazol increases proangiogeneic functions of human early endothelial progenitor cells and hybrid therapy provides a synergistic treatment effect to hindlimb ischemia animal model. [Doctoral Dissertation]. NSYSU; 2017. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0216117-100714

18. Cucato, Gabriel Grizzo. Respostas cardiovasculares agudas ao exercício físico em pacientes com claudicação intermitente.

Degree: PhD, Biodinâmica do Movimento Humano, 2013, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/39/39132/tde-02092013-110526/ ;

►

INTRODUÇÃO: A caminhada é recomendada no tratamento de pacientes com claudicação intermitente (CI) por aumentar a capacidade funcional. Porém, os efeitos cardiovasculares de uma sessão… (more)

▼

INTRODUÇÃO: A caminhada é recomendada no tratamento de pacientes com claudicação intermitente (CI) por aumentar a capacidade funcional. Porém, os efeitos cardiovasculares de uma sessão de caminhada foram pouco estudados nestes pacientes. OBJETIVO: Analisar o efeito de uma sessão de caminhada sobre a função e regulação cardiovascular pós-exercício de pacientes com CI. MATERIAS E MÉTODOS: 20 pacientes com CI participaram de duas sessões experimentais realizadas em ordem aleatória: Controle (repouso em pé por 60 minutos) e Exercício (15 séries de dois minutos de caminhada na frequência cardíaca (FC) do limiar de dor, intercaladas por dois minutos de recuperação passiva). Nas duas sessões, a pressão arterial (PA) clínica e de 24 horas, o débito cardíaco (DC - reinalação de CO2), o fluxo sanguíneo para os membros ativo e inativo (plestismografia de oclusão venosa), a capacidade vasodilatadora (hiperemia reativa) e a modulação autonômica cardiovascular (análise espectral da variabilidade da FC e da PA) foram medidas antes e após as intervenções. O volume sistólico (VS) e a resistência vascular (RV) sistêmica foram calculados. Os dados foram analisados pela ANOVA de dois fatores para amostras repetidas, post-hoc de Newman-Keuls e P<0,05. RESULTADOS: O exercício prévio reduziu a PA clínica (PA média = -7±2 mmHg, P<0,05), mas a PA ambulatorial não se modificou. Após o exercício, o VS e o DC diminuíram (-5,62±1,97ml e -0,05±0,13 l/min, P<0,05). A RV sistêmica não se elevou pós-exercício e o exercício prévio impediu o aumento da RV na região ativa e inativa, sem modificar a resposta vasodilatadora. O exercício impediu a redução da FC pós-intervenção, pois impediu o aumento da modulação vagal cardíaca. CONCLUSÃO: Uma única sessão de caminhada promoveu hipotensão pós-exercício (HPE) em pacientes com CI no ambiente clínico, mas este efeito não perdurou no período ambulatorial. A HPE ocorreu pelo efeito do exercício reduzindo o VS e o DC e, simultaneamente, impedindo o aumento da RV sistêmica

INTRODUCTION: Walking exercise (WE) is recommended for patients with intermittent claudication (IC) because it improves functional capacity. However, cardiovascular responses after one session of WE has been poor studied. OBJECTIVE: To analyze the post-effects of a WE session on cardiovascular function and regulation in patients with IC. METHODS: Twenty IC patients randomly underwent two experimental sessions: Control (rest on treadmill for 60 min) and Exercise (fifteen 2-min bouts of WE at the heart rate (HR) of the onset of claudication pain, interpolated with 2-min rest intervals). Before and after the interventions, clinic and ambulatory blood pressure (BP), cardiac output (CO, CO2 rebreathing), blood flow to active and inactive limbs (venous occlusion plethysmography), vasodilatory capacity (reactive hyperemia), cardiovascular autonomic modulation (spectral analysis of HR and BP) were measured in both experimental sessions. Stroke volume (SV) and systemic vascular resistance (VR) were calculated. Data was analyzed by a two-way ANOVA…

Advisors/Committee Members: Forjaz, Cláudia Lúcia de Moraes.

Subjects/Keywords: Aerobic exercise; Cardiovascular function; Doença arterial periférica; Exercício aeróbico; Função cardiovascular; Peripheral artery disease

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cucato, G. G. (2013). Respostas cardiovasculares agudas ao exercício físico em pacientes com claudicação intermitente. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/39/39132/tde-02092013-110526/ ;

Chicago Manual of Style (16^th Edition):

Cucato, Gabriel Grizzo. “Respostas cardiovasculares agudas ao exercício físico em pacientes com claudicação intermitente.” 2013. Doctoral Dissertation, University of São Paulo. Accessed March 03, 2021. http://www.teses.usp.br/teses/disponiveis/39/39132/tde-02092013-110526/ ;.

MLA Handbook (7^th Edition):

Cucato, Gabriel Grizzo. “Respostas cardiovasculares agudas ao exercício físico em pacientes com claudicação intermitente.” 2013. Web. 03 Mar 2021.

Vancouver:

Cucato GG. Respostas cardiovasculares agudas ao exercício físico em pacientes com claudicação intermitente. [Internet] [Doctoral dissertation]. University of São Paulo; 2013. [cited 2021 Mar 03]. Available from: http://www.teses.usp.br/teses/disponiveis/39/39132/tde-02092013-110526/ ;.

Council of Science Editors:

Cucato GG. Respostas cardiovasculares agudas ao exercício físico em pacientes com claudicação intermitente. [Doctoral Dissertation]. University of São Paulo; 2013. Available from: http://www.teses.usp.br/teses/disponiveis/39/39132/tde-02092013-110526/ ;

University of Toronto

19. Cao, Wei Jie. Targeted MicroRNA-126 and VEGF Gene Therapy for Chronic Ischemia in Diabetes.

Degree: 2015, University of Toronto

URL: http://hdl.handle.net/1807/72389

►

MicroRNAs are involved in many critical biological functions, including angiogenesis. miR-126 is an important endothelial specific angiomiR which targets negative inhibitors of the VEGF-A angiogenesis… (more)

Subjects/Keywords: Angiogenesis; Diabetes; Ischemia; micro RNA; Peripheral artery disease; Ultrasound Mediated Gene Delivery; 0564

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cao, W. J. (2015). Targeted MicroRNA-126 and VEGF Gene Therapy for Chronic Ischemia in Diabetes. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/72389

Chicago Manual of Style (16^th Edition):

Cao, Wei Jie. “Targeted MicroRNA-126 and VEGF Gene Therapy for Chronic Ischemia in Diabetes.” 2015. Masters Thesis, University of Toronto. Accessed March 03, 2021. http://hdl.handle.net/1807/72389.

MLA Handbook (7^th Edition):

Cao, Wei Jie. “Targeted MicroRNA-126 and VEGF Gene Therapy for Chronic Ischemia in Diabetes.” 2015. Web. 03 Mar 2021.

Vancouver:

Cao WJ. Targeted MicroRNA-126 and VEGF Gene Therapy for Chronic Ischemia in Diabetes. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/1807/72389.

Council of Science Editors:

Cao WJ. Targeted MicroRNA-126 and VEGF Gene Therapy for Chronic Ischemia in Diabetes. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/72389

University of Minnesota

20. Whipple, Mary. Variability in Exercise Responsiveness Among Older Adults: An Examination of Predictors and Patterns of Nonresponse to Exercise in Peripheral Artery Disease.

Degree: PhD, Nursing, 2019, University of Minnesota

URL: http://hdl.handle.net/11299/216798

► Background: Despite the significant inter-individual variability observed in outcomes of aerobic exercise programs among older adults, little is known about the prevalence of nonresponse to… (more)

▼ Background: Despite the significant inter-individual variability observed in outcomes of aerobic exercise programs among older adults, little is known about the prevalence of nonresponse to exercise in this population. Supervised exercise therapy (SET) is the primary guideline-recommended therapy for the treatment of symptomatic peripheral artery disease (PAD), yet variability in response to outcomes in this population is not well understood. Previous research suggests that individuals with PAD and comorbid diabetes may be less likely to see a benefit in physical function and quality of life outcomes following SET, yet few studies have been designed to directly compare outcomes in these populations, and no studies have examined the potential role of changes in sedentary time during the course of SET in SET outcomes. Additionally, it is unknown if patterns exist in inter- and intra-individual response across a variety of outcomes. Findings of such research could enable informed tailoring of exercise therapy programs to maximize an individual’s potential benefit. Aims: This dissertation aimed to (1) determine the prevalence of nonresponse to aerobic exercise among older adults participating in studies of aerobic exercise programs, and identify factors related to nonresponse that have been examined in the literature; (2) quantify changes in sedentary behavior among older adults with PAD, with and without diabetes, engaging in SET for the management of symptomatic PAD and examine how diabetes and changes in sedentary time are related to SET outcomes; and (3) examine the prevalence of nonresponse to SET among individuals with PAD and explore patterns of nonresponse across of a variety of relevant objective and self-reported outcomes. Methods: Aim 1. A critical review of published studies in which the authors examined variability in response, poor response, or lack of response to aerobic exercise interventions in older adults was conducted. Methods of defining nonresponse, the prevalence of nonresponse, and factors associated with nonresponse are discussed. Aim 2. A pre-test post-test study of older adults (n = 44) initiating a 12-week SET program for symptomatic PAD was conducted in a midwestern hospital system. Participants completed assessments of physical function (six-minute walk test, Short Physical Performance Battery, Walking Impairment Questionnaire), and physical activity and sedentary behavior (assessed objectively via wrist-worn accelerometer) at the time of SET initiation, 6 weeks, and 12 weeks. Changes in sedentary time overall and between participants with and without diabetes were examined. Multiple linear regression was used to examine the influence of diabetes and changes in sedentary time during SET on functional and self-reported outcomes. Aim 3. A secondary analysis of data collected as part of Aim 2 was performed to determine the prevalence of nonresponse to SET in functional and quality of life outcomes using different methods of defining nonresponse reported in the literature. Inter- and…

Subjects/Keywords: aerobic exercise; aging; peripheral artery disease; responsiveness; sedentary lifestyle; type 2 diabetes mellitus

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Whipple, M. (2019). Variability in Exercise Responsiveness Among Older Adults: An Examination of Predictors and Patterns of Nonresponse to Exercise in Peripheral Artery Disease. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/216798

Chicago Manual of Style (16^th Edition):

Whipple, Mary. “Variability in Exercise Responsiveness Among Older Adults: An Examination of Predictors and Patterns of Nonresponse to Exercise in Peripheral Artery Disease.” 2019. Doctoral Dissertation, University of Minnesota. Accessed March 03, 2021. http://hdl.handle.net/11299/216798.

MLA Handbook (7^th Edition):

Whipple, Mary. “Variability in Exercise Responsiveness Among Older Adults: An Examination of Predictors and Patterns of Nonresponse to Exercise in Peripheral Artery Disease.” 2019. Web. 03 Mar 2021.

Vancouver:

Whipple M. Variability in Exercise Responsiveness Among Older Adults: An Examination of Predictors and Patterns of Nonresponse to Exercise in Peripheral Artery Disease. [Internet] [Doctoral dissertation]. University of Minnesota; 2019. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/11299/216798.

Council of Science Editors:

Whipple M. Variability in Exercise Responsiveness Among Older Adults: An Examination of Predictors and Patterns of Nonresponse to Exercise in Peripheral Artery Disease. [Doctoral Dissertation]. University of Minnesota; 2019. Available from: http://hdl.handle.net/11299/216798

University of Toronto

21. Chen, Hou-Jen Howard. Assessment of Peripheral Microcirculation using Magnetic Resonance Imaging.

Degree: PhD, 2018, University of Toronto

URL: http://hdl.handle.net/1807/82941

► This thesis describes the development of a new measurement and analysis tool to assess the microcirculation in limb ischemia. Peripheral arterial disease (PAD) is diagnosed… (more)

▼ This thesis describes the development of a new measurement and analysis tool to assess the microcirculation in limb ischemia. Peripheral arterial disease (PAD) is diagnosed by reduced bulk blood flow and blood pressures in the legs. Patients with severe limb ischemia have limited walking ability and may experience rest pain or foot ulceration. PAD can be treated with revascularization for their large-vessel diseases. However, some patients respond poorly to revascularization. It is hypothesized that the microvascular disease component of limb ischemia may contribute to the differential outcome of revascularization. Therefore, this project is motivated to probe peripheral microvascular perfusion and to investigate the related vascular physiology and clinical indications of limb ischemia. A magnetic resonance imaging-based technique, called arterial spin labeling (ASL), was developed to characterize the dynamic perfusion response to brief periods of flow interruption. In a group of healthy subjects, the technique captured the changes of calf muscle reactive hyperemia with respect to the different durations of flow interruption, reflecting the microvascular function in regulating perfusion for different amounts of metabolic stresses. In addition, the technique also captured the differences between patients with PAD and healthy subjects in the dynamic characteristics of reactive hyperemic responses. Next, a quantitative physiological model, incorporating the influences of arterial stenoses and microvascular dysfunction, was established to facilitate the physiological interpretation of ASL reactive hyperemia. Model-derived perfusion indices were compared between subject groups. Patients were found to have higher arterial resistance and lower microvascular sensitivity to hypoxia than the healthy subject group. Finally, the perfusion measures were compared with symptom severity and functional outcome 6-month following successful endovascular revascularization in a cohort of patients. Measures of arterial resistance were related to the manifested severity, whereas the microvascular sensitivity index appeared to differentiate prognosis following revascularization. Overall, this thesis improved the ASL method to assess peripheral muscle perfusion and demonstrated the clinical relevance of perfusion measures to symptom severity and revascularization outcome of PAD for the first time. A future study with a larger patient population and longer follow-up period will be required to confirm the current findings. Advisors/Committee Members: Wright, Graham A, Medical Biophysics.

Subjects/Keywords: Arterial Spin Labeling; Microvascular Dysfunction; Perfusion; Peripheral artery disease; Reactive Hyperemia; Revascularization; 0574

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chen, H. H. (2018). Assessment of Peripheral Microcirculation using Magnetic Resonance Imaging. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/82941

Chicago Manual of Style (16^th Edition):

Chen, Hou-Jen Howard. “Assessment of Peripheral Microcirculation using Magnetic Resonance Imaging.” 2018. Doctoral Dissertation, University of Toronto. Accessed March 03, 2021. http://hdl.handle.net/1807/82941.

MLA Handbook (7^th Edition):

Chen, Hou-Jen Howard. “Assessment of Peripheral Microcirculation using Magnetic Resonance Imaging.” 2018. Web. 03 Mar 2021.

Vancouver:

Chen HH. Assessment of Peripheral Microcirculation using Magnetic Resonance Imaging. [Internet] [Doctoral dissertation]. University of Toronto; 2018. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/1807/82941.

Council of Science Editors:

Chen HH. Assessment of Peripheral Microcirculation using Magnetic Resonance Imaging. [Doctoral Dissertation]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/82941

University of Minnesota

22. Schorr, Erica Nicole. Characterization of the peripheral artery disease symptom experience.

Degree: PhD, Nursing, 2013, University of Minnesota

URL: http://hdl.handle.net/11299/167461

► Background: Claudication is the most commonly recognized symptom of PAD. It is classically described as an aching, cramping, painful, or tired feeling in the buttock… (more)

▼ Background: Claudication is the most commonly recognized symptom of PAD. It is classically described as an aching, cramping, painful, or tired feeling in the buttock or leg muscles. However, classic claudication is only reported in 7.5% to 33% of patients with PAD. Symptoms beyond classic claudication have been reported and suspected as being part of the symptom experience, but have not been validated as directly relating to changes in calf tissue oxygenation during exercise and subsequent recovery. Objective: The purpose of this study was to characterize the symptom experience of individuals diagnosed with PAD. Specific aims were to: (a) understand the symptom experience of individuals with PAD through in-depth qualitative interviews, and (b) simultaneously evaluate calf tissue oxygenation and self-reported symptoms experienced during treadmill exercise and throughout recovery. Method: Adults experiencing lower extremity symptoms during exercise due to underlying PAD were asked to participate. They were asked to: (a) complete a semi-structured interview to report their symptoms and describe their symptom experience in detail; (b) use a numeric rating scale (NRS) (0 to 5) to rate their symptoms during exercise and recovery; (c) provide descriptions of their symptom(s) during exercise and recovery; and (d) wear a near-infrared spectroscopy device to obtain information on tissue oxygenation during the exercise and recovery phases. Data were analyzed using content analysis, exploration of individual graphical trajectories, grouping trajectories, and multilevel modeling to examine the relationship between self-reported symptoms and calf tissue oxygenation. Results: A total of 40 participants were enrolled in this study. Participants were predominately Caucasian males. The average age of participants was 67.55 years (SD 9.18). Six themes emerged from 27 participant interviews: symptom descriptors, maintaining equilibrium, temporal fluctuations, the role of exercise, the perceived impact on QOL, and disease presence and treatment. During interviews, participants provided 24 symptom descriptors in 10 lower extremity locations. During treadmill exercise, participants provided 22 symptom descriptors in eight lower extremity locations. Under static and dynamic conditions, classic and `atypical' descriptors were used to describe discomfort in typical and `atypical' lower extremity locations. During three successive bouts of treadmill exercise, the largest drop in calf tissue oxygenation occurred between the start of exercise and the onset of symptom(s). During recovery, calf tissue re-saturation occurred steadily between maximum discomfort (i.e., a rating of 5 out of 5) and full symptom recovery. Individual changes in tissue oxygenation were related to total exercise time, baseline calf tissue oxygenation, exercise and recovery ratings, disease severity, and body-mass index. Conclusions: This study provides a preliminary understanding of the relationship between…

Subjects/Keywords: Claudication; Mixed methods; Near-infrared spectroscopy; Oxygenation; Peripheral artery disease; Symptom; Nursing

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schorr, E. N. (2013). Characterization of the peripheral artery disease symptom experience. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/167461

Chicago Manual of Style (16^th Edition):

Schorr, Erica Nicole. “Characterization of the peripheral artery disease symptom experience.” 2013. Doctoral Dissertation, University of Minnesota. Accessed March 03, 2021. http://hdl.handle.net/11299/167461.

MLA Handbook (7^th Edition):

Schorr, Erica Nicole. “Characterization of the peripheral artery disease symptom experience.” 2013. Web. 03 Mar 2021.

Vancouver:

Schorr EN. Characterization of the peripheral artery disease symptom experience. [Internet] [Doctoral dissertation]. University of Minnesota; 2013. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/11299/167461.

Council of Science Editors:

Schorr EN. Characterization of the peripheral artery disease symptom experience. [Doctoral Dissertation]. University of Minnesota; 2013. Available from: http://hdl.handle.net/11299/167461

Cal Poly

23. Schafer, Leah I. The Effects of Transcutaneous Electrical Neurostimulation on Analgesia and Peripheral Perfusion.

Degree: MS, Biomedical and General Engineering, 2015, Cal Poly

URL: https://digitalcommons.calpoly.edu/theses/1519 ; 10.15368/theses.2015.168

► Peripheral arterial occlusive disease (PAOD) affects 8 to 12 million Americans over the age of 50. As the disease progresses, arterial occlusions arising from… (more)

▼ Peripheral arterial occlusive disease (PAOD) affects 8 to 12 million Americans over the age of 50. As the disease progresses, arterial occlusions arising from atherosclerotic lesions inhibit normal metabolic vasodilation in the peripheries, resulting in limb ischemia and claudication. Pharmacological and surgical treatments currently used to treat both the hemodynamic and pain symptoms associated with PAOD can involve adverse and potentially life-threatening side effects. Thus, there is a need for additional innovative therapies for PAOD. Neurostimulation has a known analgesic effect on both acute and chronic pain. Although the exact mechanisms remain under investigation, local vascular tone may be modulated by neurostimulation in addition to pain modulation. The Gate Control Theory proposes that electrical activation of mechanoreceptive afferent somatosensory nerves, specifically Aβ fibers, inhibits pain signaling to the brain by activating an inhibitory interneuron in the dorsal horn of the spinal cord which dampens signaling from afferent, C type peripheral nociceptor nerves. Interestingly, Aβ fiber activation may also inhibit norepinephrine release from sympathetic nerve terminals on efferent neurons by activating α-2 adrenergic receptors along the same dermatome, resulting in localized vasodilation in both limbs. Ultimately, electrical stimulation may decrease mean blood pressure and increase local blood flow. The focus of this study was to optimize protocols and perform a small scale clinical study to investigate hemodynamic and analgesic responses to neurostimulation during acute ischemia. We hypothesized that ganglial transcutaneous electrical neurostimulation (TENS) and interferential current (IFC) treatments would decrease pain perception and vascular resistance in the periphery in young, healthy subjects. We further hypothesized that IFC may have a greater hyperemic and analgesic effect on acute ischemia than TENS as its current waveform may be more efficient at overcoming skin impedance. Interestingly, we found trends suggesting that TENS and IFC may increase vascular resistance (VR) and have no noticeable analgesic effect, though TENS may have a slightly lower increase in VR associated with an increase in pain. Further work characterizing the hemodynamic effects of different stimulus waveforms is needed to inform future research into possible neuromodulation therapies for ischemic disease. Advisors/Committee Members: Trevor Cardinal, Ph.D..

Subjects/Keywords: Neurostimulation; Ischemia; Hyperemia; Vascular Resistance; Analgesia; Peripheral Artery Occlusive Disease; Bioelectrical and Neuroengineering

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schafer, L. I. (2015). The Effects of Transcutaneous Electrical Neurostimulation on Analgesia and Peripheral Perfusion. (Masters Thesis). Cal Poly. Retrieved from https://digitalcommons.calpoly.edu/theses/1519 ; 10.15368/theses.2015.168

Chicago Manual of Style (16^th Edition):

Schafer, Leah I. “The Effects of Transcutaneous Electrical Neurostimulation on Analgesia and Peripheral Perfusion.” 2015. Masters Thesis, Cal Poly. Accessed March 03, 2021. https://digitalcommons.calpoly.edu/theses/1519 ; 10.15368/theses.2015.168.

MLA Handbook (7^th Edition):

Schafer, Leah I. “The Effects of Transcutaneous Electrical Neurostimulation on Analgesia and Peripheral Perfusion.” 2015. Web. 03 Mar 2021.

Vancouver:

Schafer LI. The Effects of Transcutaneous Electrical Neurostimulation on Analgesia and Peripheral Perfusion. [Internet] [Masters thesis]. Cal Poly; 2015. [cited 2021 Mar 03]. Available from: https://digitalcommons.calpoly.edu/theses/1519 ; 10.15368/theses.2015.168.

Council of Science Editors:

Schafer LI. The Effects of Transcutaneous Electrical Neurostimulation on Analgesia and Peripheral Perfusion. [Masters Thesis]. Cal Poly; 2015. Available from: https://digitalcommons.calpoly.edu/theses/1519 ; 10.15368/theses.2015.168

Georgia Tech

24. Martinez, Mario Daniel. Targeted drug delivery for the treatment and diagnosis of cardiovascular disease.

Degree: PhD, Biomedical Engineering (Joint GT/Emory Department), 2017, Georgia Tech

URL: http://hdl.handle.net/1853/59201

► Cardiovascular disease has accounted for more deaths than any other major cause of death in the United States every year since 1900, with the exception… (more)

▼ Cardiovascular disease has accounted for more deaths than any other major cause of death in the United States every year since 1900, with the exception of 1918. Despite improvements in the management of cardiovascular disease, there is still a need for new and improved treatments and diagnostics. In peripheral artery disease (PAD), treatment with pro-angiogenic growth factors, such as vascular endothelial growth factor (VEGF), is currently being explored. However, there is a need to overcome limitations of this therapy, such as the growth factor’s short half-life, inadequate delivery to target tissue, and inadequate retention at target tissue. In myocarditis, a large number of patients go undiagnosed due to the disease’s heterogeneous etiology, pathophysiology, and clinical presentation. Current diagnostic techniques, such as endomyocardial biopsy and cardiac magnetic resonance, are inadequate, and there is a need for new technologies for the appropriate diagnosis and timely treatment of myocarditis. This dissertation aims to explore two different targeting techniques for the treatment and diagnosis of PAD and myocarditis. In PAD, ischemic tissue undergoes necrosis and releases cellular contents, including DNA, into extracellular space. A modified Hoechst compound has been previously used to target extracellular DNA in an animal model of myocardial infarction. We explored using a similar modified Hoechst compound to target extracellular DNA in an animal model PAD and deliver VEGF to ischemic tissue. Despite promising initial results, we did not observe any improvements in the retention or targeting of our compound to ischemic tissue when compared to non-Hoechst controls. Myocarditis is characterized by the presence of localized or diffuse inflammation in the myocardium. In an animal model of myocarditis, we used an in vivo phage display library to identify peptides that preferentially targeted this diseased myocardium. Ex vivo screening of potential peptides was then used to identify two peptides whose binding correlated with disease severity. In vivo screening was used to demonstrate that one of these peptides identified animals with severe myocarditis. Immunohistochemistry and proteonomic analysis was then used to identify potential cell and protein targets of this peptide. Through these approaches, two different techniques for the treatment and diagnosis of cardiovascular disease have been explored. These insights will advance the development of new techniques for the better treatment and diagnosis of cardiovascular disease. Advisors/Committee Members: Davis, Michael E. (committee member), Taylor, W Robert (committee member), Prausnitz, Mark R. (committee member), Botchwey, Edward A. (committee member), Brewster, Luke P. (committee member).

Subjects/Keywords: Peripheral artery disease; Hoechst; VEGF; Myocariditis; Imaging; Peptide; Phage display; Molecular imaging

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Martinez, M. D. (2017). Targeted drug delivery for the treatment and diagnosis of cardiovascular disease. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/59201

Chicago Manual of Style (16^th Edition):

Martinez, Mario Daniel. “Targeted drug delivery for the treatment and diagnosis of cardiovascular disease.” 2017. Doctoral Dissertation, Georgia Tech. Accessed March 03, 2021. http://hdl.handle.net/1853/59201.

MLA Handbook (7^th Edition):

Martinez, Mario Daniel. “Targeted drug delivery for the treatment and diagnosis of cardiovascular disease.” 2017. Web. 03 Mar 2021.

Vancouver:

Martinez MD. Targeted drug delivery for the treatment and diagnosis of cardiovascular disease. [Internet] [Doctoral dissertation]. Georgia Tech; 2017. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/1853/59201.

Council of Science Editors:

Martinez MD. Targeted drug delivery for the treatment and diagnosis of cardiovascular disease. [Doctoral Dissertation]. Georgia Tech; 2017. Available from: http://hdl.handle.net/1853/59201

University of Pennsylvania

25. Englund, Erin Kristine. Functional Evaluation of the Peripheral Vasculature Using Magnetic Resonance Imaging.

Degree: 2016, University of Pennsylvania

URL: https://repository.upenn.edu/edissertations/1700

► Akin to cardiac stress testing, functional integrity of the peripheral vasculature can be interrogated by measuring the response to a stimulus. Recent reports suggest that… (more)

▼ Akin to cardiac stress testing, functional integrity of the peripheral vasculature can be interrogated by measuring the response to a stimulus. Recent reports suggest that the reactive hyperemia response, the physiologic reaction following induced ischemia, is associated with disease presence, correlated with disease severity, and may be a sensitive biomarker of pre-clinical disease. In this dissertation, an innovative, interleaved magnetic resonance imaging method is developed, termed Perfusion, Intravascular Venous Oxygen saturation, and T2* (PIVOT), which simultaneously measures microvascular perfusion, venous oxygen saturation (SvO2), and the blood-oxygen-level dependent (BOLD) signal. PIVOT is first applied in healthy subjects to demonstrate its ability to measure reactive hyperemia response dynamics. Next, reactive hyperemia perfusion is compared between the more temporally efficient pulsed arterial spin labeling (PASL) used in PIVOT and the more recently developed and preferred method for the brain, pseudo-continuous ASL (pCASL). Assessment of the impact of blood flow variability throughout the ischemia-reperfusion paradigm on pCASL perfusion quantification is investigated. Then, both PASL and pCASL sequences are used to measure reactive hyperemia perfusion in healthy subjects. No significant differences were detected between perfusion measured with PASL or pCASL despite different labeling strategies, temporal resolutions, and perfusion quantification models. Subsequently, PIVOT is combined with a velocity-encoded dual-echo GRE to create an interleaved three-slice sequence that provides quantification of bulk blood flow in the arteries and veins in addition to the traditional PIVOT measures. This new sequence, termed Velocity and PIVOT (vPIVOT) is used to investigate the relationship of blood flow in the macro- and microvasculature and muscle oxygen consumption during the transition from exercise to rest. Finally, PIVOT is applied clinically in a cohort of patients with varying degrees of severity of peripheral artery disease. Increasing disease severity was correlated with a prolongation of the hyperemic response time, measured as a lengthening of time to peak perfusion, SvO2 washout time, and time to peak T2*. In addition, peak perfusion and SvO2 upslope were significantly different between patients with PAD and healthy controls. These results suggest the potential for PIVOT to evaluate disease severity and may present a tool to assess response to therapeutic intervention.

Subjects/Keywords: blood flow; dynamic oximetry; magnetic resonance imaging; perfusion; peripheral artery disease; reactive hyperemia; Biomedical

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Englund, E. K. (2016). Functional Evaluation of the Peripheral Vasculature Using Magnetic Resonance Imaging. (Thesis). University of Pennsylvania. Retrieved from https://repository.upenn.edu/edissertations/1700

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Englund, Erin Kristine. “Functional Evaluation of the Peripheral Vasculature Using Magnetic Resonance Imaging.” 2016. Thesis, University of Pennsylvania. Accessed March 03, 2021. https://repository.upenn.edu/edissertations/1700.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Englund, Erin Kristine. “Functional Evaluation of the Peripheral Vasculature Using Magnetic Resonance Imaging.” 2016. Web. 03 Mar 2021.

Vancouver:

Englund EK. Functional Evaluation of the Peripheral Vasculature Using Magnetic Resonance Imaging. [Internet] [Thesis]. University of Pennsylvania; 2016. [cited 2021 Mar 03]. Available from: https://repository.upenn.edu/edissertations/1700.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Englund EK. Functional Evaluation of the Peripheral Vasculature Using Magnetic Resonance Imaging. [Thesis]. University of Pennsylvania; 2016. Available from: https://repository.upenn.edu/edissertations/1700

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Duke University

26. Abbas, Hasan. An Essential Role for Skeletal Muscle Progenitor Cells in Response to Ischemia in Vascular Disease .

Degree: 2020, Duke University

URL: http://hdl.handle.net/10161/20857

► Peripheral artery disease (PAD) is nearly as common as coronary artery disease, but few effective treatments exist, and it is associated with significant morbidity… (more)

▼ Peripheral artery disease (PAD) is nearly as common as coronary artery disease, but few effective treatments exist, and it is associated with significant morbidity and mortality. Although PAD studies have focused on the vascular response to ischemia, studies from our lab indicate that skeletal muscle cells, particularly Pax7-expressing muscle progenitor cells (MPCs), also known as satellite cells, may play a critically important role in determining the phenotypic manifestation of PAD. Here, we demonstrate that genetic ablation of satellite cells in a murine model of PAD resulted in a complete absence of normal muscle regeneration following ischemic injury, despite a lack of morphological or physiological changes in resting muscle. Compared to ischemic muscle of control mice (Pax7WT), the ischemic limb of Pax7-deficient mice (Pax7∆) was unable to generate significant force 7- or 28-days after hind limb ischemia (HLI) in ex vivo force measurement studies. A dramatic increase in adipose infiltration was observed 28 days after HLI in Pax7∆ mice, which replaced functional muscle, a phenotype seen in PAD patients with severe disease. To investigate the mechanism of these adipogenic changes, we first investigated whether a pool of progenitor cells known as fibro-adipogenic progenitors (FAPs) was upregulated and demonstrated an increase in the expression of their canonical marker PDGFRα in Pax7∆ mice. Inhibition of FAPs using the drug batimastat resulted in a decrease in muscle adipose tissue and a corresponding increase in fibrosis. MPCs cultured from mouse muscle tissue failed to form myotubes in vitro following depletion of satellite cells in vivo, and they displayed an increased propensity to differentiate into fat in adipogenic medium. Importantly, this phenotype was recapitulated in patients with critical limb ischemia (CLI), the most severe form of PAD. Skeletal muscle samples from CLI patients demonstrated an increase in adipose deposition in more ischemic regions of muscle, which corresponded with a decrease in the number of satellite cells in those regions. Collectively, these data demonstrate that Pax7+ MPCs are required for normal muscle regeneration after ischemic injury, and they suggest that targeting muscle regeneration may be an important therapeutic approach to prevent muscle degeneration in PAD. Future studies will focus on the role of other supporting cells (such as pericytes) and the cross-talk between FAPs and satellite cells in ischemic muscle regeneration. Advisors/Committee Members: Pendergast, Ann Marie (advisor), Kontos, Christopher D (advisor).

Subjects/Keywords: Cellular biology; Biology; Histology; Adipogenesis; Ischemia; Pax7; Peripheral artery disease; Satellite Cells

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Abbas, H. (2020). An Essential Role for Skeletal Muscle Progenitor Cells in Response to Ischemia in Vascular Disease . (Thesis). Duke University. Retrieved from http://hdl.handle.net/10161/20857

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Abbas, Hasan. “An Essential Role for Skeletal Muscle Progenitor Cells in Response to Ischemia in Vascular Disease .” 2020. Thesis, Duke University. Accessed March 03, 2021. http://hdl.handle.net/10161/20857.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Abbas, Hasan. “An Essential Role for Skeletal Muscle Progenitor Cells in Response to Ischemia in Vascular Disease .” 2020. Web. 03 Mar 2021.

Vancouver:

Abbas H. An Essential Role for Skeletal Muscle Progenitor Cells in Response to Ischemia in Vascular Disease . [Internet] [Thesis]. Duke University; 2020. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/10161/20857.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Abbas H. An Essential Role for Skeletal Muscle Progenitor Cells in Response to Ischemia in Vascular Disease . [Thesis]. Duke University; 2020. Available from: http://hdl.handle.net/10161/20857

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

27. Gemignani, Tiago, 1976-. Tensão circunferencial poplítea em posição ortostática se associa à presença local de aterosclerose em pacientes com fatores de risco cardiovascular: Popliteal circumferencial wall tension induced by orthostatic body posture is associated with local atherosclerotic plaques in patients with cardiovascular risk factors.

Degree: 2013, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/312294

► Abstract: Lower limb arteries are exposed to higher hemodynamic burden in erectile posture. This study evaluated the effects of body posture on popliteal, carotid and… (more)

▼ Abstract: Lower limb arteries are exposed to higher hemodynamic burden in erectile posture. This study evaluated the effects of body posture on popliteal, carotid and brachial circumferential wall tension (CWT) and investigated the relationship between local CWT and atherosclerotic plaques in subjects with cardiovascular risk factors. Two hundred and three subjects (118 women and 85 men) with cardiovascular risk factors (smoking, hypertension or diabetes mellitus) underwent clinical and laboratory analysis and had their blood pressure measured in the arm and calf in supine and orthostatic positions. Arteries were evaluated by ultrasound analysis, while CWT was calculated according to Laplace's law. Among the enrolled participants, 47%, 29% and none presented popliteal, carotid and brachial plaques, respectively. Carotid CWT measurements were not associated with local plaques after adjustment for potential confounders. Conversely, general linear model and logistic regression analyses adjusted for potential confounders demonstrated that peak orthostatic CWT was the only local hemodynamic parameter showing significant relationship with popliteal plaques in the whole sample. In gender-specific analyses, although positively correlated with popliteal plaques in both genders, local peak orthostatic CWT exhibited an independent association with popliteal plaques after adjustment for potential confounders only in women. In conclusion, popliteal CWT measured in orthostatic posture, rather than in supine position, is associated with popliteal atherosclerotic plaques, particularly in women. These findings suggest that orthostatic posture might play a role in the atherogenesis of leg arteries by modifying local hemodynamic forces and that there may be gender differences in this regard Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Nadruz Junior, Wilson, 1973- (advisor), Junior, Wilson Nadruz (advisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Clínica Médica (nameofprogram), Sposito, Andrei Carvalho (committee member), Bittencourt, Luiz Antonio Kannebley (committee member), Zornoff, Leonardo Antonio Mamede (committee member), Drager, Luciano Ferreira (committee member).

Subjects/Keywords: Artéria poplítea; Doença arterial periférica; Doenças das artérias carótidas; Popliteal artery; Peripheral arterial disease; Carotid artery diseases

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gemignani, Tiago, 1. (2013). Tensão circunferencial poplítea em posição ortostática se associa à presença local de aterosclerose em pacientes com fatores de risco cardiovascular: Popliteal circumferencial wall tension induced by orthostatic body posture is associated with local atherosclerotic plaques in patients with cardiovascular risk factors. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/312294

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gemignani, Tiago, 1976-. “Tensão circunferencial poplítea em posição ortostática se associa à presença local de aterosclerose em pacientes com fatores de risco cardiovascular: Popliteal circumferencial wall tension induced by orthostatic body posture is associated with local atherosclerotic plaques in patients with cardiovascular risk factors.” 2013. Thesis, Universidade Estadual de Campinas. Accessed March 03, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312294.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gemignani, Tiago, 1976-. “Tensão circunferencial poplítea em posição ortostática se associa à presença local de aterosclerose em pacientes com fatores de risco cardiovascular: Popliteal circumferencial wall tension induced by orthostatic body posture is associated with local atherosclerotic plaques in patients with cardiovascular risk factors.” 2013. Web. 03 Mar 2021.

Vancouver:

Gemignani, Tiago 1. Tensão circunferencial poplítea em posição ortostática se associa à presença local de aterosclerose em pacientes com fatores de risco cardiovascular: Popliteal circumferencial wall tension induced by orthostatic body posture is associated with local atherosclerotic plaques in patients with cardiovascular risk factors. [Internet] [Thesis]. Universidade Estadual de Campinas; 2013. [cited 2021 Mar 03]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/312294.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gemignani, Tiago 1. Tensão circunferencial poplítea em posição ortostática se associa à presença local de aterosclerose em pacientes com fatores de risco cardiovascular: Popliteal circumferencial wall tension induced by orthostatic body posture is associated with local atherosclerotic plaques in patients with cardiovascular risk factors. [Thesis]. Universidade Estadual de Campinas; 2013. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/312294

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

York University

28. De Ciantis, Matthew John. The Role of Endothelial FoxO Proteins in Coordinating Skeletal Muscle Recovery Following Hind Limb Ischemia.

Degree: MSc -MS, Kinesiology & Health Science, 2020, York University

URL: http://hdl.handle.net/10315/37788

► Muscle regeneration requires inflammation followed by microvascular growth and blood-flow recovery; however, these are impaired in ischemic muscle of peripheral artery disease patients. Endothelial cell… (more)

Subjects/Keywords: Health sciences; Vascular disease; muscle regeneration; blood vessels; blood flow recovery; muscle health; inflammation; atherosclerosis; ischemia; peripheral artery disease

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

De Ciantis, M. J. (2020). The Role of Endothelial FoxO Proteins in Coordinating Skeletal Muscle Recovery Following Hind Limb Ischemia. (Masters Thesis). York University. Retrieved from http://hdl.handle.net/10315/37788

Chicago Manual of Style (16^th Edition):

De Ciantis, Matthew John. “The Role of Endothelial FoxO Proteins in Coordinating Skeletal Muscle Recovery Following Hind Limb Ischemia.” 2020. Masters Thesis, York University. Accessed March 03, 2021. http://hdl.handle.net/10315/37788.

MLA Handbook (7^th Edition):

De Ciantis, Matthew John. “The Role of Endothelial FoxO Proteins in Coordinating Skeletal Muscle Recovery Following Hind Limb Ischemia.” 2020. Web. 03 Mar 2021.

Vancouver:

De Ciantis MJ. The Role of Endothelial FoxO Proteins in Coordinating Skeletal Muscle Recovery Following Hind Limb Ischemia. [Internet] [Masters thesis]. York University; 2020. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/10315/37788.

Council of Science Editors:

De Ciantis MJ. The Role of Endothelial FoxO Proteins in Coordinating Skeletal Muscle Recovery Following Hind Limb Ischemia. [Masters Thesis]. York University; 2020. Available from: http://hdl.handle.net/10315/37788

Vilnius University

29. Pyragytė, Simona. Sergančiųjų diabetu periferinės arterijų ligos rizikos veiksniai ir padariniai.

Degree: Master, 2014, Vilnius University

URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20140704_172236-62581 ;

►

Tyrimo objektas. 27–90 metų asmenys, sergantys pirmojo ir antrojo tipo diabetu ir periferinių arterijų liga, gydyti Vilniaus universiteto kraujagyslių chirurgijos centre Vilniaus miesto universitetinėje ligoninėje… (more)

▼

Tyrimo objektas. 27–90 metų asmenys, sergantys pirmojo ir antrojo tipo diabetu ir periferinių arterijų liga, gydyti Vilniaus universiteto kraujagyslių chirurgijos centre Vilniaus miesto universitetinėje ligoninėje 1997–2011 m. Tyrimo tikslas. Nustatyti Vilniaus universiteto kraujagyslių chirurgijos centre Vilniaus miesto universitetinėje ligoninėje gydytų pacientų, sergančių diabetu, periferinių arterijų ligos ypatumus, PAL padarinius ir PAL padarinių rizikos veiksnius. Tyrimo medžiaga ir metodai. Išanalizuotos 925 pacientų, sergančių 1 ir 2 tipo diabetu ir 1997–2011 metais gydytų Vilniaus universiteto kraujagyslių chirurgijos centre Vilniaus miesto universitetinėje ligoninėje nuo periferinių arterijų ligos istorijos. Statistinė analizė atlikta SPSS 19.0 for Windows programų paketu. Pasirinktas statistinio reikšmingumo lygmuo α=0,05. Rezultatai. Ištyrėme 387 moterų ir 538 vyrų, duomenis. Vidutinis tiriamųjų amžius buvo 67,99±9,47 metų. 95,6 proc. tiriamųjų sirgo 2 tipo diabetu. Vidutinė sirgimo diabetu trukmė buvo 12,95±9,91 metų. Diabetinę angiopatiją turėjo 47,8 proc. tiriamųjų, nefropatiją – 34,9 proc., retinopatiją – 14,6 proc., polineuropatiją – 33,7 proc.. Statistiškai reikšmingai dažniau nefropatija, retinopatija ir polineuropatija buvo nustatyta pacientams, sergantiems 1 tipo diabetu. Pacientai dažniausiai sirgo širdies ir kraujagyslių sistemos ligomis. 21,2 proc. tiriamųjų jau buvo patyrę galūnių amputacijas. Vidutinė hospitalizacijos trukmė buvo 17,3±10,80... [toliau žr. visą tekstą]

Object of the research. 27–90 years old patients having the type 1 and type 2 diabetes mellitus and peripheral artery disease, who were treated at the Vilnius University Vascular Surgery Center in the Vilnius town University Hospital in the year 1997–2011. The aim of our research was. To analyse aspects of peripheral artery disease in patients with diabetes mellitus, who were cured at Vilnius University Vascular Surgery Center in the Vilnius town University Hospital as well as to determine the consequenses of PAD and the risk factors PAD. Material and methods of the research. 925 cases of the type 1 and type 2 diabetes mellitus were explored at the Vilnius University Vascular Surgery center in the Vilnius town University hospital in the year 1997–2011, who received treatment for the peripheral artery disease. The statistic survey has been done using the program pack SPSS 19.0 for Windows. Statistic importance level α=0.05. Results. Data about 378 women and 538 men have been explored. An average age of all the patients was 67.99±9.47 years. 95.6% of patients had the type 2 diabetes mellitus. An average duration of having disease was 12.95±9.91 years, 47.8% of cases had diabetic angiopathy, 34.9% of patients had nephropaty, 14.6% of cases had retinopathy, 33.7% of all the cases had polyneuropathy. According to the statistic importance rates retinopathy, nephropathy, polyneuropathy are more often among patients with the type 1 diabetes mellitus. Cardiovascular diseases were... [to full text]

Advisors/Committee Members: Zabulienė, Lina (Master's thesis supervisor).

Subjects/Keywords: Cukrinis diabetas; Amputacija; Lėtinė galūnių išemija; Periferinių arterijų liga/peripheral artery disease; Peripheral vascular disease; Diabetes mellitus; Claudication intermittens; Amputation; Chronic critical limb ischaemia

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pyragytė, Simona. (2014). Sergančiųjų diabetu periferinės arterijų ligos rizikos veiksniai ir padariniai. (Masters Thesis). Vilnius University. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20140704_172236-62581 ;

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Chicago Manual of Style (16^th Edition):

Pyragytė, Simona. “Sergančiųjų diabetu periferinės arterijų ligos rizikos veiksniai ir padariniai.” 2014. Masters Thesis, Vilnius University. Accessed March 03, 2021. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20140704_172236-62581 ;.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

MLA Handbook (7^th Edition):

Pyragytė, Simona. “Sergančiųjų diabetu periferinės arterijų ligos rizikos veiksniai ir padariniai.” 2014. Web. 03 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

Pyragytė, Simona. Sergančiųjų diabetu periferinės arterijų ligos rizikos veiksniai ir padariniai. [Internet] [Masters thesis]. Vilnius University; 2014. [cited 2021 Mar 03]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20140704_172236-62581 ;.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Council of Science Editors:

Pyragytė, Simona. Sergančiųjų diabetu periferinės arterijų ligos rizikos veiksniai ir padariniai. [Masters Thesis]. Vilnius University; 2014. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20140704_172236-62581 ;

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

30. Chehuen, Marcel da Rocha. Efeito do treinamento de caminhada sobre o risco, a função e a regulação cardiovasculares em indivíduos com claudicação intermitente.

Degree: PhD, Biodinâmica do Movimento Humano, 2014, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/39/39132/tde-11052015-095750/ ;

►

O treinamento de caminhada (TC) é recomendado para o tratamento de indivíduos com claudicação intermitente (CI) porque melhora a capacidade de caminhada. Além disso, seria… (more)

▼

O treinamento de caminhada (TC) é recomendado para o tratamento de indivíduos com claudicação intermitente (CI) porque melhora a capacidade de caminhada. Além disso, seria interessante que o TC também promovesse modificações benéficas no sistema cardiovascular, pois os eventos cardiovasculares são a principal causa de morte nestes indivíduos. No entanto, os efeitos cardiovasculares do TC em indivíduos com CI foi pouco estudado. Assim, o objetivo deste estudo foi verificar o efeito do TC sobre o risco, a função e a regulação cardiovasculares em indivíduos com CI. Quarenta e dois indivíduos com CI foram divididos de forma aleatória em 2 grupos: controle (GC, n=20, sessões de 30 min de alongamento) e treinamento de caminhada (GT, n=22, 15 séries de 2 min de caminhada em intensidade correspondente à frequência cardíaca (FC) do limiar de dor intercalados por 2 min de repouso passivo). Nos dois grupos, a intervenção foi realizada 2 vezes/semana durante 12 semanas consecutivas. No início e ao final do estudo, os indivíduos realizaram as seguintes avaliações: glicemia e perfil lipídico de jejum; índice de massa corporal; capacidade de caminhada; consumo de oxigênio no 1º estágio e no pico do teste de esforço; índice tornozelo-braço (ITB) de repouso; janela isquêmica após teste ergoespirométrico; pressão arterial (PA) em repouso (auscultatória) e de 24 horas (oscilométrica); débito cardíaco (DC - reinalação de CO2); FC (ECG); volume sistólico (VS); resistência vascular (RV) sistêmica, do antebraço e da perna (plestismografia); componentes de alta (AF) e baixa (BF) frequência da variabilidade da FC; e sensibilidade barorreflexa espontânea (SBR). Mudanças significantes (P<0,05) ao longo do tempo e entre os grupos foram verificadas pela análise de variância ANOVA de dois fatores para medidas repetidas. O TC aumentou significantemente a capacidade de caminhada (Δ=+302±85m) e a SBR (Δ=+2.13±1.07 ms/mmHg), e diminuiu o VO2) no 1º estágio do teste (Δ=-1,8±0,4ml.kg-1.min-1), a janela isquêmica (Δ=- 0,40±0,38mmHg.min.m-1), a PA média (Δ=-5±2mmHg), a variabilidade da PA média de 24h (Δ=-0,8±0,2mmHg), o DC (Δ=-0.37±0.24L/min), a FC (Δ=- 4±2bpm), a RV do antebraço (Δ=-8.5±2.8 U) e a razão BF/AF (Δ=-1.24±0.99). A glicemia, o perfil lipídico, o índice de massa corporal, o VO2) pico, o ITB de repouso e a RV sistêmica e da perna não foram modificadas pelo TC. Não houve mudança em nenhuma variável no GC. Em conclusão, o TC melhorou a capacidade de caminhada, a economia de caminhada e a janela isquêmica. Além disso, o TC melhorou a função (PA, DC, FC e RV antebraço) e a regulação (BF/AF e SBR) cardiovasculares em indivíduos com CI. Estas alterações fornecem suporte adicional para a utilização do TC no tratamento de indivíduos com CI

Walking training (WT) is recommended for the treatment of patients with intermittent claudication (IC) because it improves walking capacity. Moreover, it would be interesting that WT also promotes beneficial changes on cardiovascular system, since…

Advisors/Committee Members: Forjaz, Cláudia Lúcia de Moraes.

Subjects/Keywords: Aerobic exercise; Autonomic modulation; Blood pressure, Hemodynamic; Doença arterial periférica; Exercício aeróbico; Hemodinâmica; Modulação autonômica; Peripheral artery disease; Pressão arterial

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chehuen, M. d. R. (2014). Efeito do treinamento de caminhada sobre o risco, a função e a regulação cardiovasculares em indivíduos com claudicação intermitente. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/39/39132/tde-11052015-095750/ ;

Chicago Manual of Style (16^th Edition):

Chehuen, Marcel da Rocha. “Efeito do treinamento de caminhada sobre o risco, a função e a regulação cardiovasculares em indivíduos com claudicação intermitente.” 2014. Doctoral Dissertation, University of São Paulo. Accessed March 03, 2021. http://www.teses.usp.br/teses/disponiveis/39/39132/tde-11052015-095750/ ;.

MLA Handbook (7^th Edition):

Chehuen, Marcel da Rocha. “Efeito do treinamento de caminhada sobre o risco, a função e a regulação cardiovasculares em indivíduos com claudicação intermitente.” 2014. Web. 03 Mar 2021.

Vancouver:

Chehuen MdR. Efeito do treinamento de caminhada sobre o risco, a função e a regulação cardiovasculares em indivíduos com claudicação intermitente. [Internet] [Doctoral dissertation]. University of São Paulo; 2014. [cited 2021 Mar 03]. Available from: http://www.teses.usp.br/teses/disponiveis/39/39132/tde-11052015-095750/ ;.

Council of Science Editors:

Chehuen MdR. Efeito do treinamento de caminhada sobre o risco, a função e a regulação cardiovasculares em indivíduos com claudicação intermitente. [Doctoral Dissertation]. University of São Paulo; 2014. Available from: http://www.teses.usp.br/teses/disponiveis/39/39132/tde-11052015-095750/ ;

		in
And / Or
		in
And / Or
		in
And / Or
		in

Open Access Theses and Dissertations