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University of North Carolina – Greensboro

1. La, Stephanie. Evaluation of the Lewis rat as a model of periodontitis: a preliminary study.

Degree: 2015, University of North Carolina – Greensboro

Strategies for prevention and treatment of periodontitis are lacking due to difficulty studying this disease in a controlled clinical environment and the lack of suitable animal models. In this study, the Lewis rat was evaluated as a potential model of periodontitis. It was hypothesized that the Lewis rat, when provided a high sucrose/high casein diet (H-SC) long-term (23 weeks), will develop characteristics of periodontitis. This study evaluated: 1) gene expression of local inflammation, disease progression, and bacterial infection in the gingival and alveolar mucosa tissue; 2) gene expression of systemic inflammation in the liver; and 3) metabolic endpoints of body composition, bone densitometric endpoints, and serum leptin and insulin levels. Additionally, age-related differences were evaluated between old control rats and young (6 weeks old) control rats. Interleukin-6 was 2-fold higher in gingival tissue of the old H-SC fed rats when compared to old control rats. No other differences between the old H-SC fed rats and old control rats were found for any other genes in gingival or alveolar mucosa tissue or in the liver. Metabolic endpoints of the old H-SC group were significantly higher in only bone mineral density (5% higher) and liver mass (10% higher) compared to old control rats. Two-fold higher levels of RANKL gene expression and markedly lower metabolic endpoints were evident in young control rats when compared to old control rats, as was expected due to the ~5 month age difference. In conclusion, this animal model developed mild periodontitis. Furthermore, there was no age-related differences between old control rats and young control rats in periodontal endpoints.; Animal model, High sucrose/casein diet, Lewis rat, Periodontitis Advisors/Committee Members: Deborah Kipp (advisor).

Subjects/Keywords: Periodontitis – Animal models; Rats as laboratory animals

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

La, S. (2015). Evaluation of the Lewis rat as a model of periodontitis: a preliminary study. (Doctoral Dissertation). University of North Carolina – Greensboro. Retrieved from http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=18441

Chicago Manual of Style (16th Edition):

La, Stephanie. “Evaluation of the Lewis rat as a model of periodontitis: a preliminary study.” 2015. Doctoral Dissertation, University of North Carolina – Greensboro. Accessed December 12, 2019. http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=18441.

MLA Handbook (7th Edition):

La, Stephanie. “Evaluation of the Lewis rat as a model of periodontitis: a preliminary study.” 2015. Web. 12 Dec 2019.

Vancouver:

La S. Evaluation of the Lewis rat as a model of periodontitis: a preliminary study. [Internet] [Doctoral dissertation]. University of North Carolina – Greensboro; 2015. [cited 2019 Dec 12]. Available from: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=18441.

Council of Science Editors:

La S. Evaluation of the Lewis rat as a model of periodontitis: a preliminary study. [Doctoral Dissertation]. University of North Carolina – Greensboro; 2015. Available from: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=18441

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