subject:(Pediatrics)

University of Lund

1. Lauruschkus, Katarina. Participation in physical activities and sedentary behaviour among children with physical disabilities.

Degree: 2015, University of Lund

URL: https://lup.lub.lu.se/record/4940807 ; https://portal.research.lu.se/ws/files/3406247/5051300.pdf

► Participating in physical activity promotes physical and mental health. Children with physical disabilities are not as physically active as other children. They tend to participate… (more)

▼ Participating in physical activity promotes physical and mental health. Children with physical disabilities are not as physically active as other children. They tend to participate in lower intensity physical activity, choose more passive activities with less variety and have more sedentary time. The overall aim of this thesis was to gain knowledge about participation in physical activities, to identify associated factors for school and leisure time and to explore the perceived experiences of the children and the parents about possible facilitators or barriers associated with physical activities. A further aim was to evaluate the feasibility and effectiveness of Physical Activity Referral (PAR) and outcome measures for children with physical disabilities and its effectiveness on increasing participation in physical activity and decreasing sedentary behaviour. The thesis is comprised of three studies with children with various gross- and fine motor, communicative and cognitive functions. In Study I (Paper I) a total population of 364 children and adolescents with cerebral palsy (CP) aged 7-17 years was studied by using cross-sectional data from the National Quality Registry CP follow-up programme (CPUP). In Study II qualitative interviews with 16 children with CP, aged 8-11 years (Paper II), and with 25 of their parents (Paper III) were performed and analysed by content analysis. In Study III (Paper IV), 14 children with physical disabilities, aged 7-12 years, participated in PAR together with 24 of their parents. The intervention was based on a written agreement of self-selected physical activities, motivational interviewing (MI), goal-directed outcome measurements Canadian Occupational Performance measure (COPM) and Goal Attainment Scaling (GAS) and assessments including Gross Motor Function Measure (GMFM-66), physical activity monitors, the International Physical Activity Questionnaire (IPAQ) and other questionnaires at baseline, and after 8 and 11 months. Children and adolescents with more severe motor limitations, with intellectual disability and with thinness seem to have the greatest needs for interventions to increase their participation in physical activities and reduce sedentary behaviour. Children discussed that they want to be asked about their wishes and needs, and get the opportunity to try self-selected physical activities with individualised support, as well as to have fun with family and friends, have someone to do the activity with and enjoy the sensation of speed. Environmental factors could be either facilitators or barriers, while pain, fatigue and the perception of not being good enough were considered barriers. The parents experienced several challenges when their child wanted to be physically active: parents wanted to protect their child while also pushing them towards independence. They wanted competent persons to be available to assist their child in participating in the physical activities and support them in finding friends to be active with. Family culture and attitudes affect children’s…

Subjects/Keywords: Pediatrics

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APA (6^th Edition):

Lauruschkus, K. (2015). Participation in physical activities and sedentary behaviour among children with physical disabilities. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/4940807 ; https://portal.research.lu.se/ws/files/3406247/5051300.pdf

Chicago Manual of Style (16^th Edition):

Lauruschkus, Katarina. “Participation in physical activities and sedentary behaviour among children with physical disabilities.” 2015. Doctoral Dissertation, University of Lund. Accessed March 04, 2021. https://lup.lub.lu.se/record/4940807 ; https://portal.research.lu.se/ws/files/3406247/5051300.pdf.

MLA Handbook (7^th Edition):

Lauruschkus, Katarina. “Participation in physical activities and sedentary behaviour among children with physical disabilities.” 2015. Web. 04 Mar 2021.

Vancouver:

Lauruschkus K. Participation in physical activities and sedentary behaviour among children with physical disabilities. [Internet] [Doctoral dissertation]. University of Lund; 2015. [cited 2021 Mar 04]. Available from: https://lup.lub.lu.se/record/4940807 ; https://portal.research.lu.se/ws/files/3406247/5051300.pdf.

Council of Science Editors:

Lauruschkus K. Participation in physical activities and sedentary behaviour among children with physical disabilities. [Doctoral Dissertation]. University of Lund; 2015. Available from: https://lup.lub.lu.se/record/4940807 ; https://portal.research.lu.se/ws/files/3406247/5051300.pdf

University of Lund

2. Sveinsdottir, Snjolaug. Preterm intraventricular haemorrhage - Effects of extracellular haemoglobin.

Degree: 2014, University of Lund

URL: https://lup.lub.lu.se/record/4754548 ; https://portal.research.lu.se/ws/files/3722962/4754566.pdf

► Intraventricular haemorrhage (IVH) is the most common brain lesion in preterm infants and is most commonly seen in the sickest children, with 15-20% of very… (more)

▼ Intraventricular haemorrhage (IVH) is the most common brain lesion in preterm infants and is most commonly seen in the sickest children, with 15-20% of very preterm infants developing IVH. The mortality of infants with severe IVH is 20-50 % in the neonatal period and over 50 % of surviving infants develop post-haemorrhagic ventricular dilatation (PHVD) and 40-80 % develop severe neurological impairment, mainly cerebral palsy and mental retardation. To date there is no available therapy to prevent infants from developing either hydrocephalus or serious neurological disability. Infants who develop hydrocephalus receive a life-long ventriculo-peritoneal shunt, which is an efficient means of preventing ventricular distension but does not reduce neurological impairment. Mechanisms leading to brain damage and hydrocephalus following IVH are complex and incompletely understood. However, inflammation and oxidative stress have been identified as two major culprits leading to irreversible damage in the vulnerable immature periventricular brain matter. Dysfunction of cerebrospinal fluid (CSF) production contributes to the development of PHVD but the exact molecular mechanisms remain unknown. The choroid plexus, which produces the CSF, is adjacent to the origin of IVH and is the first organ to encounter the extravasated blood. The subsequent haemolysis of red blood cells causes release of cell-free haemoglobin (Hb), which will with time further degrade releasing the toxic substances hemin, free iron, and various ROS (reactive oxygen species). Metabolites of cell-free Hb have been identified as an initiator of inflammation in the context of adult cerebral haemorrhage and inflammation of the ependyma has been shown to cause alterations of the blood-brain barrier (BBB). Our working hypothesis is that cell-free Hb and its metabolites act as causal initiators of inflammation following IVH, constituting a critical up-stream event eventually leading to periventricular cell death. We further hypothesize that inflammation of the choroid plexus alters the ability of the epithelium to maintain CSF homeostasis contributing to the formation of post-haemorrhagic hydrocephalus. To test the hypothesis we used the rabbit pup model of preterm IVH. It is excellently suited since rabbit pups have a germinal matrix with vulnerable capillary meshwork prone to rupture and have CNS maturation comparable to a 28-30 weeks preterm human infant. The application of high-frequency ultrasound enabled accurate measurements of haemorrhagic size and distension as well as ultrasound guided intraventricular injections and CSF sampling. Following IVH there is a release of free haemoglobin in its reduced form, oxyHb, into the intraventricular space. OxyHb autooxidises to metHb over time and the concentration of the key inflammatory cytokine TNF-α is highly correlated to that of metHb. In an astrocyte cell culture, metHb induces TNF-α production whereas oxyHb does not. We therefore conclude that the formation of metHb is a key up-stream event leading to inflammation…

Subjects/Keywords: Pediatrics

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APA (6^th Edition):

Sveinsdottir, S. (2014). Preterm intraventricular haemorrhage - Effects of extracellular haemoglobin. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/4754548 ; https://portal.research.lu.se/ws/files/3722962/4754566.pdf

Chicago Manual of Style (16^th Edition):

Sveinsdottir, Snjolaug. “Preterm intraventricular haemorrhage - Effects of extracellular haemoglobin.” 2014. Doctoral Dissertation, University of Lund. Accessed March 04, 2021. https://lup.lub.lu.se/record/4754548 ; https://portal.research.lu.se/ws/files/3722962/4754566.pdf.

MLA Handbook (7^th Edition):

Sveinsdottir, Snjolaug. “Preterm intraventricular haemorrhage - Effects of extracellular haemoglobin.” 2014. Web. 04 Mar 2021.

Vancouver:

Sveinsdottir S. Preterm intraventricular haemorrhage - Effects of extracellular haemoglobin. [Internet] [Doctoral dissertation]. University of Lund; 2014. [cited 2021 Mar 04]. Available from: https://lup.lub.lu.se/record/4754548 ; https://portal.research.lu.se/ws/files/3722962/4754566.pdf.

Council of Science Editors:

Sveinsdottir S. Preterm intraventricular haemorrhage - Effects of extracellular haemoglobin. [Doctoral Dissertation]. University of Lund; 2014. Available from: https://lup.lub.lu.se/record/4754548 ; https://portal.research.lu.se/ws/files/3722962/4754566.pdf

University of Lund

3. Harling, Solweig. Quantification of left-to-right shunt through Patent Ductus Arteriosus by colour Doppler.

Degree: 2011, University of Lund

URL: https://lup.lub.lu.se/record/2065161 ; https://portal.research.lu.se/ws/files/3858095/2065176.pdf

► The aim of this thesis was to develop a non-invasive method to quantify the size of a shunt through a patent ductus arteriosus (PDA) by… (more)

▼ The aim of this thesis was to develop a non-invasive method to quantify the size of a shunt through a patent ductus arteriosus (PDA) by ultrasound and to test its usability in clinical settings. There is no consensus regarding the optimal management strategy for a PDA in premature infants. Non-steroidal anti-inflammatory drugs (NSAID) are the first treatment of choice. The use of NSAIDs, especially indomethacin, should be carefully balanced, as they have their disadvantages. In our experimental study in lambs, indomethacin acutely reduced the coronary flow by up to 50% and the effect lasted for up to one hour. In our lamb model, we developed a non-invasive method to quantify the ductal shunt by ultrasound. The flow was measured with electromagnetic flow meters in the ascending aorta and in the ductus and a colour Doppler image was obtained simultaneously over the main pulmonary artery longitudinal cross-section including ductal inflow. The percentage of colour pixels representing ductal flow was quantified in the main pulmonary artery outlined by anatomic landmarks. There was a correlation between the ratio of pulmonary to systemic flow (Qp/Qs) and the percentage of total colours covering the cross-section and there was an even better correlation with green pixels alone. When the Qp/Qs was ≥ 1.5:1, the percentage of green pixels in PALS was ≥ 50. In children admitted for the device closure of the open ductus, the method had 92% sensitivity for a measured Qp/Qs of ≥ 1.5. In preterm infants during the first three days of life, the ductal diameter but not the quantified ductal shunt predicted the need for treatment. We showed further that the perinatal cytokine burden during the first three days of life is not associated with an increased need to close the ductus, but it is associated with increased ductal diameter and reduced systolic blood pressure. We suggest that our method could be used as a non-invasive tool to determine a haemodynamically significant ductal shunt. Using the evaluated Qp/Qs of > 1.5:1 as a guide for treatment decisions might reduce the need for unnecessary interventions and reduce complications.

Subjects/Keywords: Pediatrics

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APA (6^th Edition):

Harling, S. (2011). Quantification of left-to-right shunt through Patent Ductus Arteriosus by colour Doppler. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/2065161 ; https://portal.research.lu.se/ws/files/3858095/2065176.pdf

Chicago Manual of Style (16^th Edition):

Harling, Solweig. “Quantification of left-to-right shunt through Patent Ductus Arteriosus by colour Doppler.” 2011. Doctoral Dissertation, University of Lund. Accessed March 04, 2021. https://lup.lub.lu.se/record/2065161 ; https://portal.research.lu.se/ws/files/3858095/2065176.pdf.

MLA Handbook (7^th Edition):

Harling, Solweig. “Quantification of left-to-right shunt through Patent Ductus Arteriosus by colour Doppler.” 2011. Web. 04 Mar 2021.

Vancouver:

Harling S. Quantification of left-to-right shunt through Patent Ductus Arteriosus by colour Doppler. [Internet] [Doctoral dissertation]. University of Lund; 2011. [cited 2021 Mar 04]. Available from: https://lup.lub.lu.se/record/2065161 ; https://portal.research.lu.se/ws/files/3858095/2065176.pdf.

Council of Science Editors:

Harling S. Quantification of left-to-right shunt through Patent Ductus Arteriosus by colour Doppler. [Doctoral Dissertation]. University of Lund; 2011. Available from: https://lup.lub.lu.se/record/2065161 ; https://portal.research.lu.se/ws/files/3858095/2065176.pdf

University of Lund

4. Davoudi, Mina. Effect of experimental complex III deficiency on respiratory chain assembly and function.

Degree: 2014, University of Lund

URL: https://lup.lub.lu.se/record/4696648 ; https://portal.research.lu.se/ws/files/3535424/4699118.pdf

► The assembly of respiratory chain complexes in the mitochondrial inner membrane requires specific factors. Once assembled to form a mature functional complex, complex III (CIII)… (more)

Subjects/Keywords: Pediatrics

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APA (6^th Edition):

Davoudi, M. (2014). Effect of experimental complex III deficiency on respiratory chain assembly and function. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/4696648 ; https://portal.research.lu.se/ws/files/3535424/4699118.pdf

Chicago Manual of Style (16^th Edition):

Davoudi, Mina. “Effect of experimental complex III deficiency on respiratory chain assembly and function.” 2014. Doctoral Dissertation, University of Lund. Accessed March 04, 2021. https://lup.lub.lu.se/record/4696648 ; https://portal.research.lu.se/ws/files/3535424/4699118.pdf.

MLA Handbook (7^th Edition):

Davoudi, Mina. “Effect of experimental complex III deficiency on respiratory chain assembly and function.” 2014. Web. 04 Mar 2021.

Vancouver:

Davoudi M. Effect of experimental complex III deficiency on respiratory chain assembly and function. [Internet] [Doctoral dissertation]. University of Lund; 2014. [cited 2021 Mar 04]. Available from: https://lup.lub.lu.se/record/4696648 ; https://portal.research.lu.se/ws/files/3535424/4699118.pdf.

Council of Science Editors:

Davoudi M. Effect of experimental complex III deficiency on respiratory chain assembly and function. [Doctoral Dissertation]. University of Lund; 2014. Available from: https://lup.lub.lu.se/record/4696648 ; https://portal.research.lu.se/ws/files/3535424/4699118.pdf

University of Arizona

5. Zmrzel, Sara Cortnie. Increasing Healthcare Provider Knowledge about Pediatric Vaccine Administration Pain Mitigation Techniques: A Quality Improvement Project .

Degree: 2018, University of Arizona

URL: http://hdl.handle.net/10150/631363

► Background: Vaccines, which are very important aspects of a child’s health are aimed at keeping children and the public safe but are known to be… (more)

Subjects/Keywords: Pediatrics

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APA (6^th Edition):

Zmrzel, S. C. (2018). Increasing Healthcare Provider Knowledge about Pediatric Vaccine Administration Pain Mitigation Techniques: A Quality Improvement Project . (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/631363

Chicago Manual of Style (16^th Edition):

Zmrzel, Sara Cortnie. “Increasing Healthcare Provider Knowledge about Pediatric Vaccine Administration Pain Mitigation Techniques: A Quality Improvement Project .” 2018. Doctoral Dissertation, University of Arizona. Accessed March 04, 2021. http://hdl.handle.net/10150/631363.

MLA Handbook (7^th Edition):

Zmrzel, Sara Cortnie. “Increasing Healthcare Provider Knowledge about Pediatric Vaccine Administration Pain Mitigation Techniques: A Quality Improvement Project .” 2018. Web. 04 Mar 2021.

Vancouver:

Zmrzel SC. Increasing Healthcare Provider Knowledge about Pediatric Vaccine Administration Pain Mitigation Techniques: A Quality Improvement Project . [Internet] [Doctoral dissertation]. University of Arizona; 2018. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10150/631363.

Council of Science Editors:

Zmrzel SC. Increasing Healthcare Provider Knowledge about Pediatric Vaccine Administration Pain Mitigation Techniques: A Quality Improvement Project . [Doctoral Dissertation]. University of Arizona; 2018. Available from: http://hdl.handle.net/10150/631363

University of Lund

6. Sveinsdottir, Kristbjorg. Cerebellar development and very preterm birth interactions with neonatal events.

Degree: 2018, University of Lund

URL: https://lup.lub.lu.se/record/805ad2f0-d52d-436b-9358-efb7502d2423 ; https://portal.research.lu.se/ws/files/46061742/thesis_for_publisering.pdf

► AbstractThe cerebellum is an important part of the brain and in very preterm infants the cerebellum is smaller at term equivalent age compared to that… (more)

▼ AbstractThe cerebellum is an important part of the brain and in very preterm infants the cerebellum is smaller at term equivalent age compared to that of infants born at term.Hypothesis and aims: The general hypothesis is that preterm birth per se causes cerebellar underdevelopment and that certain events following preterm birth, either complications or treatments, can aggravate the underdevelopment. The general aim is to evaluate how preterm birth in association with potentially damaging events i.e., intraventricular hemorrhage (IVH), the neurovascular disease retinopathy of prematurity (ROP) and the widely used adenosine antagonist caffeine, can affect the cerebellar development.Methods: Paper I. Postnatal growth, cerebellar external granular layer (EGL) development and circulating IGF-1 levels were evaluated following preterm birth in rabbit pups and compared to that of term pups to evaluate if the preterm rabbit pup model is suitable for future cerebellar studies. Paper II. The distribution and effect of cell-free hemoglobin (Hb) on cerebellar development was evaluated following IVH in preterm rabbit pups and compared to preterm pups without an IVH. Additionally the effect of the cell-free Hb scavenger Haptoglobin (Hp) was evaluated. Paper III. The relationship between any stage of ROP, brain volumes and developmental outcome was evaluated in very preterm infants. Paper IV. The effect of caffeine on cerebellar development and the Insulin-like growth factor 1 (IGF-1) system was evaluated in preterm rabbit pups given enterally administered caffeine and compared to control preterm pups.Results: Paper I. Mean weight and circulating levels of IGF-1 were significantly lower in preterm pups at all time- points (all p<0.05). Postnatal weight correlated with circulating IGF-1 (r2=0.89) independantly of gestational age at birth and postnatal age. Proliferation was reduced in preterm pups at postnatal day 2 (P2) compared to term pups (p=0.01). Purkinje cells in the preterm pups exhibited reduced calbindin staining at P0 (p=0.003), P2 (p=0.004) and P5 (p=0.04) compared term group. Paper II. IVH was associated with a decreased proliferative (Ki67 positive) portion of the EGL, delayed Purkinje cell maturation, and activated microglia in cerebellar white matter. Immunolabeling at P0 in pups with IVH, demonstrated a widespread presence of cell-free Hb in all cerebellar layers. Intraventricular injection of Hp resulted in a distribution of Hp corresponding to that of cell-free Hb in the cerebellar layers and a partial reversion of the damaging effects observed following IVH. Paper III. Infants with any stage of ROP had lower unmyelinated white matter volume (UWMV) (p<0.001), cerebellar volume (p<0.001), mental developmental index (p<0.001) and psychomotor developmental index (p=0.002) compared to infants without ROP. Paper IV. Caffeine treatment did not affect weight development, serum IGF-1 or hepatic expression of mRNA for IGF-1 at any given time-point. Cerebellar densities of IGF-1R, calbindin positive Purkinje cells and Ki67…

Subjects/Keywords: Pediatrics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sveinsdottir, K. (2018). Cerebellar development and very preterm birth interactions with neonatal events. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/805ad2f0-d52d-436b-9358-efb7502d2423 ; https://portal.research.lu.se/ws/files/46061742/thesis_for_publisering.pdf

Chicago Manual of Style (16^th Edition):

Sveinsdottir, Kristbjorg. “Cerebellar development and very preterm birth interactions with neonatal events.” 2018. Doctoral Dissertation, University of Lund. Accessed March 04, 2021. https://lup.lub.lu.se/record/805ad2f0-d52d-436b-9358-efb7502d2423 ; https://portal.research.lu.se/ws/files/46061742/thesis_for_publisering.pdf.

MLA Handbook (7^th Edition):

Sveinsdottir, Kristbjorg. “Cerebellar development and very preterm birth interactions with neonatal events.” 2018. Web. 04 Mar 2021.

Vancouver:

Sveinsdottir K. Cerebellar development and very preterm birth interactions with neonatal events. [Internet] [Doctoral dissertation]. University of Lund; 2018. [cited 2021 Mar 04]. Available from: https://lup.lub.lu.se/record/805ad2f0-d52d-436b-9358-efb7502d2423 ; https://portal.research.lu.se/ws/files/46061742/thesis_for_publisering.pdf.

Council of Science Editors:

Sveinsdottir K. Cerebellar development and very preterm birth interactions with neonatal events. [Doctoral Dissertation]. University of Lund; 2018. Available from: https://lup.lub.lu.se/record/805ad2f0-d52d-436b-9358-efb7502d2423 ; https://portal.research.lu.se/ws/files/46061742/thesis_for_publisering.pdf

University of Cape Town

7. Mwenda, Lona Albertha. An Examination of Lumbar and Ventricular Cerebrospinal Fluid Findings in Children with Tuberculous Meningitis and Hydrocephalus.

Degree: MMed, Paediatrics and Child Health, 2019, University of Cape Town

URL: http://hdl.handle.net/11427/31073

► Background: Childhood tuberculous meningitis (TBM) has poor outcomes. These are often associated with delayed diagnosis because early diagnosis and treatment is challenging. Existing diagnostic criteria… (more)

▼ Background: Childhood tuberculous meningitis (TBM) has poor outcomes. These are often associated with delayed diagnosis because early diagnosis and treatment is challenging. Existing diagnostic criteria use CSF characteristics to suspect TBM. However, lumbar and ventricular CSF may differ. These differences have not been well characterised Sometimes only ventricular CSF is available and decisions about surgical treatment may be influenced by CSF characteristics. This study examined CSF parameters from lumbar and ventricular compartments in patients with TBM and hydrocephalus who required neurosurgical procedures, their CSF temporal profiles, differentials between compartments, and factors that may influence these results. Methodology: A descriptive cross-sectional study was conducted including data from two prospective TBM studies. Children treated for TBM and hydrocephalus at Red Cross War Memorial Children’s Hospital with lumbar and/ or ventricular samples were selected. Pooled lumbar verses ventricular samples and paired time-linked samples in individual patients were analysed. Differences in CSF cell counts and biochemistry parameters across compartments were analyzed using Wilcoxon signed rank test, and temporal profiles graphically presented. Associations between laboratory, clinical and radiological data were analyzed using Mann-Whitney’s U test. To test for associated factors, results of the nature of hydrocephalus (level of CSF obstruction) and spinal imaging were analyzed where available. Association between CSF parameters and morbidity was analyzed. Results: Eighty-one patients were studied, 29 had time-linked paired CSF. The mean patient age was 36 months (2- 156 months), 93% were HIV-uninfected, and the mortality rate was 13.6%. Seventy-two percent had communicating hydrocephalus, 16% non-communicating, and 12% uncertain (unable to demonstrate level of block). Medians of admission lumbar CSF showed low glucose (2.2 mmol/L), low chloride (112 mmol/L), raised protein (2g/L) and elevated white cell count (165 x 106 /L). Corresponding values for admission ventricular CSF were minimally affected glucose (3mmol/L), mildly low to normal chloride (114.5mmol/L), normal to mildly raised protein (0.5g/L) and less elevated white cell count (22 x 106 /L). In paired samples, all parameters were significantly different between lumbar and ventricular CSF. Ventricular CSF showed milder aberrations than lumbar CSF: lower protein and total white cell count, higher glucose and chloride. All paired samples showed higher lumbar CSF protein; lower lumbar CSF chloride in almost 80%; lower lumbar CSF glucose in 96%. Analysis of possible factors was limited by the small patient numbers who had full brain and spine imaging, and also paired CSF samples (n=17). However, maximum lumbar CSF protein was associated with severity of spinal disease on imaging. The lymphocyte ratio between lumbar and ventricular CSF was higher in patients with non-communicating and uncertain hydrocephalus. CSF parameters normalized slowly. White cell count… Advisors/Committee Members: Figaji, Anthony (advisor), Rohlwink, Ursula (advisor), Diedericks, Ralph (advisor).

Subjects/Keywords: Pediatrics

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APA (6^th Edition):

Mwenda, L. A. (2019). An Examination of Lumbar and Ventricular Cerebrospinal Fluid Findings in Children with Tuberculous Meningitis and Hydrocephalus. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/31073

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mwenda, Lona Albertha. “An Examination of Lumbar and Ventricular Cerebrospinal Fluid Findings in Children with Tuberculous Meningitis and Hydrocephalus.” 2019. Thesis, University of Cape Town. Accessed March 04, 2021. http://hdl.handle.net/11427/31073.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mwenda, Lona Albertha. “An Examination of Lumbar and Ventricular Cerebrospinal Fluid Findings in Children with Tuberculous Meningitis and Hydrocephalus.” 2019. Web. 04 Mar 2021.

Vancouver:

Mwenda LA. An Examination of Lumbar and Ventricular Cerebrospinal Fluid Findings in Children with Tuberculous Meningitis and Hydrocephalus. [Internet] [Thesis]. University of Cape Town; 2019. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11427/31073.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mwenda LA. An Examination of Lumbar and Ventricular Cerebrospinal Fluid Findings in Children with Tuberculous Meningitis and Hydrocephalus. [Thesis]. University of Cape Town; 2019. Available from: http://hdl.handle.net/11427/31073

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Lund

8. Irestorm, Elin. Sad, shattered or slow? Fatigue after childhood cancer.

Degree: 2021, University of Lund

URL: https://lup.lub.lu.se/record/4d91d1a7-aac5-49bd-bdc9-b374dc57fbec ; https://portal.research.lu.se/ws/files/91461522/e_spik_Elin_Irestorm.pdf

► Systematic assessments of cognition, fatigue, and mental health in survivors ofchildhood cancer can serve two different purposes. One is to enable research about development over… (more)

Subjects/Keywords: Pediatrics

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APA (6^th Edition):

Irestorm, E. (2021). Sad, shattered or slow? Fatigue after childhood cancer. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/4d91d1a7-aac5-49bd-bdc9-b374dc57fbec ; https://portal.research.lu.se/ws/files/91461522/e_spik_Elin_Irestorm.pdf

Chicago Manual of Style (16^th Edition):

Irestorm, Elin. “Sad, shattered or slow? Fatigue after childhood cancer.” 2021. Doctoral Dissertation, University of Lund. Accessed March 04, 2021. https://lup.lub.lu.se/record/4d91d1a7-aac5-49bd-bdc9-b374dc57fbec ; https://portal.research.lu.se/ws/files/91461522/e_spik_Elin_Irestorm.pdf.

MLA Handbook (7^th Edition):

Irestorm, Elin. “Sad, shattered or slow? Fatigue after childhood cancer.” 2021. Web. 04 Mar 2021.

Vancouver:

Irestorm E. Sad, shattered or slow? Fatigue after childhood cancer. [Internet] [Doctoral dissertation]. University of Lund; 2021. [cited 2021 Mar 04]. Available from: https://lup.lub.lu.se/record/4d91d1a7-aac5-49bd-bdc9-b374dc57fbec ; https://portal.research.lu.se/ws/files/91461522/e_spik_Elin_Irestorm.pdf.

Council of Science Editors:

Irestorm E. Sad, shattered or slow? Fatigue after childhood cancer. [Doctoral Dissertation]. University of Lund; 2021. Available from: https://lup.lub.lu.se/record/4d91d1a7-aac5-49bd-bdc9-b374dc57fbec ; https://portal.research.lu.se/ws/files/91461522/e_spik_Elin_Irestorm.pdf

University of Helsinki

9. Schrade, Anja. Transcriptional control in the murine adrenal cortex and testis.

Degree: Institute of Clinical Medicine, Children's Hospital; Washington University in St. Louis, St. Louis, MO, USA, 2016, University of Helsinki

URL: http://hdl.handle.net/10138/160814

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The main steroidogenic organs in mammals, the adrenal glands and gonads, arise from a common pool of mesodermal progenitor cells during embryogenesis. Precise gene regulation… (more)

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The main steroidogenic organs in mammals, the adrenal glands and gonads, arise from a common pool of mesodermal progenitor cells during embryogenesis. Precise gene regulation controls cell differentiation, growth, and homeostasis in the developing embryo and the adult. Disruptions of these spatiotemporal processes are linked to a variety of diseases, including developmental disorders, malignant transformations, and infertility. This dissertation focuses on the molecular mechanisms that regulate normal and neoplastic cell development in the adrenal cortex and testis of the mouse. The initiation of gene transcription requires the binding of transcription factors to specific cis-regulatory elements within DNA. Methylation of cytosine residues affects transcription factor binding to these regulatory elements; hypermethylation results in condensed chromatin that is inaccessible to the transcriptional machinery, whereas hypomethylation is an indicator of active gene transcription. Alterations in DNA methylation have been linked to neoplasia. We used a novel method of genome-wide methylation profiling, termed Laser Capture Microdissection-Reduced Representation Bisulfite Sequencing, to characterize the changes in promoter methylation associated with gonadectomy-induced adrenocortical neoplasia in the mouse. One of the genes upregulated during gonadectomy-induced adrenocortical neoplasia is Gata4, a transcription factor normally absent in the adult adrenal gland. To determine whether GATA4 directly modulates tumorigenesis we analyzed mice with germline or conditional loss-of-function mutations in this gene. GATA4 deficiency was associated with reduced tumor growth and decreased expression of sex steroidogenic markers. GATA4 is expressed in testicular Leydig cells. To gain insight into the role of GATA4 in this cell type, we performed gene silencing experiments in a mouse Leydig cell tumor line (mLTC-1) and in primary mouse Leydig cells. Comprehensive analyses, including transcriptomic and metabolomic profiling, showed that Gata4 silencing was associated with diminished sex steroid production and impaired glycolysis. Conditional deletion of Gata4 in another testicular somatic cell type, the Sertoli cell, has been reported to increase the permeability of the blood-testis barrier (BTB) and disrupt spermatogenesis in adult mice. To elucidate the molecular underpinnings of these phenotypic abnormalities, we performed Gata4 gene silencing experiments in an immortalized Sertoli cell line (TM4) and in primary mouse Sertoli cells. GATA4 depletion was associated with altered expression of genes involved in BTB maintenance, including components of tight/adherens junctions (e.g., Tjp1, Cldn12) and the extracellular matrix (e.g., Lamc1, Col4a5). Gata4 gene silencing impaired the production of lactate, a key Sertoli cell-derived nutrient that is essential for proper spermatogenesis.

Nisäkkäiden kaksi tärkeintä steroidihormoneja erittävä elintä, lisämunuaiset ja sukurauhaset, saavat alkunsa yhteisistä esiastesoluista…

Subjects/Keywords: pediatrics; pediatrics

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APA (6^th Edition):

Schrade, A. (2016). Transcriptional control in the murine adrenal cortex and testis. (Doctoral Dissertation). University of Helsinki. Retrieved from http://hdl.handle.net/10138/160814

Chicago Manual of Style (16^th Edition):

Schrade, Anja. “Transcriptional control in the murine adrenal cortex and testis.” 2016. Doctoral Dissertation, University of Helsinki. Accessed March 04, 2021. http://hdl.handle.net/10138/160814.

MLA Handbook (7^th Edition):

Schrade, Anja. “Transcriptional control in the murine adrenal cortex and testis.” 2016. Web. 04 Mar 2021.

Vancouver:

Schrade A. Transcriptional control in the murine adrenal cortex and testis. [Internet] [Doctoral dissertation]. University of Helsinki; 2016. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10138/160814.

Council of Science Editors:

Schrade A. Transcriptional control in the murine adrenal cortex and testis. [Doctoral Dissertation]. University of Helsinki; 2016. Available from: http://hdl.handle.net/10138/160814

Vanderbilt University

10. -8630-0255. The Relationship among Maternal Characteristics, Maternal Dietary Self-Regulation, and the Dietary Intake and Body Weight Status of Two to Five-Year-Old Children.

Degree: PhD, Nursing Science, 2020, Vanderbilt University

URL: http://hdl.handle.net/1803/10105

► Background: Eating preferences and practices are established early in life, yet we have little knowledge about how mothers make food decisions on behalf of their… (more)

▼ Background: Eating preferences and practices are established early in life, yet we have little knowledge about how mothers make food decisions on behalf of their children. These decisions, however, lay the foundation for their child’s lifelong food preferences and eating behaviors. Almost one-third of all children in the U.S. are overweight or obese putting them at high risk for becoming an overweight or obese adult. To make a difference in the ongoing obesity epidemic, we must better understand the relationship among characteristics of the mother who controls the young child’s access to food, food choices, and feeding practices. This knowledge will undergird future interventions. Purpose: This study explored associations among mothers’ dietary self-regulation, stress, feeding practices and body mass index (BMI) and her child’s BMI and dietary intake, and, identified influential contextual factors in a sample of mothers of preschool children ages 2-5 years. Inclusion criteria: mothers > 18 years of age with a child 2-5 years of age, able to read English, and self-identify as the primary parent caregiver. Exclusion criteria: child with a previously diagnosed medical condition affecting their ability to eat, and mothers who did not have access to a device to complete the electronic survey. Methods: Two-phase study with sequential explanatory design: cross-sectional, correlational design using quantitative methods; qualitative approach using individual interviews. Study sample included 419 who completed a survey and a subset of the sample (N=10) completed in-depth interviews. Mothers were recruited from daycare centers and CloudResearch, a participant sourcing platform. Results: Median maternal age was 34.1 years (IQR 29-38) with median education of 13 years (IQR 12-16). About 94% of the mothers in the study were overweight or obese. Median child BMI z-score was .56 (IQR -.8 – 2.1). After controlling for maternal demographics, perceived child weight variables, maternal perceived stress, and maternal BMI, the addition of dietary self-regulation and child feeding practices demonstrated a statistically significant increase in explained variance in child BMI (R2 change = .08, p < .001). Qualitative data revealed barriers to child positive feeding practices including maternal competing obligations and lack of guidance from the pediatric healthcare provider. Advisors/Committee Members: Lutenbacher, Melanie (advisor).

Subjects/Keywords: obesity; pediatrics

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APA (6^th Edition):

-8630-0255. (2020). The Relationship among Maternal Characteristics, Maternal Dietary Self-Regulation, and the Dietary Intake and Body Weight Status of Two to Five-Year-Old Children. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/10105

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Chicago Manual of Style (16^th Edition):

-8630-0255. “The Relationship among Maternal Characteristics, Maternal Dietary Self-Regulation, and the Dietary Intake and Body Weight Status of Two to Five-Year-Old Children.” 2020. Doctoral Dissertation, Vanderbilt University. Accessed March 04, 2021. http://hdl.handle.net/1803/10105.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

MLA Handbook (7^th Edition):

-8630-0255. “The Relationship among Maternal Characteristics, Maternal Dietary Self-Regulation, and the Dietary Intake and Body Weight Status of Two to Five-Year-Old Children.” 2020. Web. 04 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

-8630-0255. The Relationship among Maternal Characteristics, Maternal Dietary Self-Regulation, and the Dietary Intake and Body Weight Status of Two to Five-Year-Old Children. [Internet] [Doctoral dissertation]. Vanderbilt University; 2020. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1803/10105.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Council of Science Editors:

-8630-0255. The Relationship among Maternal Characteristics, Maternal Dietary Self-Regulation, and the Dietary Intake and Body Weight Status of Two to Five-Year-Old Children. [Doctoral Dissertation]. Vanderbilt University; 2020. Available from: http://hdl.handle.net/1803/10105

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

11. Tandon, Vishnukumar. Immunoglobulin profile in measles; -.

Degree: Medicine, 1990, Bundelkhand University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/12500

None

Bibliography and Appendix given

Advisors/Committee Members: Ramesh Kumar.

Subjects/Keywords: Pediatrics

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APA (6^th Edition):

Tandon, V. (1990). Immunoglobulin profile in measles; -. (Thesis). Bundelkhand University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/12500

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tandon, Vishnukumar. “Immunoglobulin profile in measles; -.” 1990. Thesis, Bundelkhand University. Accessed March 04, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/12500.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tandon, Vishnukumar. “Immunoglobulin profile in measles; -.” 1990. Web. 04 Mar 2021.

Vancouver:

Tandon V. Immunoglobulin profile in measles; -. [Internet] [Thesis]. Bundelkhand University; 1990. [cited 2021 Mar 04]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/12500.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tandon V. Immunoglobulin profile in measles; -. [Thesis]. Bundelkhand University; 1990. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/12500

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Stellenbosch University

12. Bux, Fathima. Eating patterns of Indian preschool children between 1-5 years of age in Howick West (Kwa-Zulu Natal).

Degree: Mnutr, Paediatrics and Child Health, 2003, Stellenbosch University

URL: http://hdl.handle.net/10019.1/53399

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ENGLISH ABSTRACT: Most of the risk factors for coronary heart disease (CHD) such as hypertension, dyslipidaemia, smoking, non-insulin dependent diabetes mellitus (NIDDM), obesity, physical inactivity… (more)

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ENGLISH ABSTRACT: Most of the risk factors for coronary heart disease (CHD) such as hypertension, dyslipidaemia, smoking, non-insulin dependent diabetes mellitus (NIDDM), obesity, physical inactivity and heredity are common in South African populations, with Indians ranking among those with the highest prevalence in the country. Little published literature is available on eating patterns in pre-school children in the Indian population. Therefore, this study a ims to assess the nutritional status of a group of Indian pre-school children in Howick West (a small suburb in the Kwa-Zulu Natal Midlands). Methods: This was a cross-sectional study of 50 Indian pre-school children between the ages of 1-5 years, randomly selected from a total of 632 available Indian households in Howick West. Written, informed consent was obtained from the mother/caregiver of each child that participated in the study. Standardized and validated 24-hour-recall (24-H-R) and quantitative food frequency questionnaires (QFFQ), used in the National Food Consumption Survey (NFCS) of 1999, were adapted and used to assess habitual intake and eating patterns of the 50 Indian pre-school children. Height and weight measurements using standardized methodology were used to assess the anthropometric status of the children. Results: The prevalence of underweight was 14%. Stunting affected only 8% of the children, and 2% were at risk of overweight. The mean energy intakes of the children were above that recommended for age. A high fat intake was observed, with total fat contributing 42% to the daily total energy (TE) intake. The contributions of total carbohydrate and protein to TE intake were 45% and 10%, respectively. Low mean intakes of the following micronutrients were observed (less than 67% of the RDA): Calcium (22% of the children), Vitamin D (90%), Zinc (56%) and Iodine (90%), respectively. Based on the 24-H-R, the intakes of the remaining micronutrients were either above or equivalent to that recommended for age when compared to the 1989 RDAs. Conclusions: Despite a relatively high prevalence of underweight compared to overweight in these preschoolers, dietary analysis has indicated adequate dietary intakes in terms of total energy recommended for the age groups studied. However, total fat intake which represented 42% of TE, was high, with saturated fat (SF) contributing 15% to TE intake. This finding is cause for concern as excessive consumption of dietary fat has been implicated in the aetiology of CVD, obesity and some forms of cancer, and CHD is one of the main causes of morbidity and mortality in South Africa, especially among the Indian segment of the population.

AFRIKAANSE OPSOMMING: Meeste van die risikofaktore vir koronêre hartsiektes (KHS) soos hipertensie, dislipidemie, rook, nie-insulien afhanklike diabetes (NIADM), vetsug, fisiese onaktiwiteit en oorerflikheid, kom algemeen onder Suid-Afrikaanse bevolkingsgroepe voor, met Indiërs onder dié met die hoogste voorkoms in die land. Min gepubliseerde …

Advisors/Committee Members: Labadarios, D., Herselman, M. G., Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Paediatrics and Child Health..

Subjects/Keywords: Pediatrics

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APA (6^th Edition):

Bux, F. (2003). Eating patterns of Indian preschool children between 1-5 years of age in Howick West (Kwa-Zulu Natal). (Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/53399

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bux, Fathima. “Eating patterns of Indian preschool children between 1-5 years of age in Howick West (Kwa-Zulu Natal).” 2003. Thesis, Stellenbosch University. Accessed March 04, 2021. http://hdl.handle.net/10019.1/53399.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bux, Fathima. “Eating patterns of Indian preschool children between 1-5 years of age in Howick West (Kwa-Zulu Natal).” 2003. Web. 04 Mar 2021.

Vancouver:

Bux F. Eating patterns of Indian preschool children between 1-5 years of age in Howick West (Kwa-Zulu Natal). [Internet] [Thesis]. Stellenbosch University; 2003. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10019.1/53399.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bux F. Eating patterns of Indian preschool children between 1-5 years of age in Howick West (Kwa-Zulu Natal). [Thesis]. Stellenbosch University; 2003. Available from: http://hdl.handle.net/10019.1/53399

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. Marek, Emily. Building a Medical Neighborhood Through Medical Home and Home Visiting Collaboration; Examining the Associations Between Rhode Island’s First Connections and Early Intervention Home Visiting Programs.

Degree: School of Public Health, 2017, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:733439/

* Advisors/Committee Members: Vivier, Patrick (Reader), Gjelsvik, Annie (Advisor).

Subjects/Keywords: Pediatrics

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APA (6^th Edition):

Marek, E. (2017). Building a Medical Neighborhood Through Medical Home and Home Visiting Collaboration; Examining the Associations Between Rhode Island’s First Connections and Early Intervention Home Visiting Programs. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:733439/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Marek, Emily. “Building a Medical Neighborhood Through Medical Home and Home Visiting Collaboration; Examining the Associations Between Rhode Island’s First Connections and Early Intervention Home Visiting Programs.” 2017. Thesis, Brown University. Accessed March 04, 2021. https://repository.library.brown.edu/studio/item/bdr:733439/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Marek, Emily. “Building a Medical Neighborhood Through Medical Home and Home Visiting Collaboration; Examining the Associations Between Rhode Island’s First Connections and Early Intervention Home Visiting Programs.” 2017. Web. 04 Mar 2021.

Vancouver:

Marek E. Building a Medical Neighborhood Through Medical Home and Home Visiting Collaboration; Examining the Associations Between Rhode Island’s First Connections and Early Intervention Home Visiting Programs. [Internet] [Thesis]. Brown University; 2017. [cited 2021 Mar 04]. Available from: https://repository.library.brown.edu/studio/item/bdr:733439/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Marek E. Building a Medical Neighborhood Through Medical Home and Home Visiting Collaboration; Examining the Associations Between Rhode Island’s First Connections and Early Intervention Home Visiting Programs. [Thesis]. Brown University; 2017. Available from: https://repository.library.brown.edu/studio/item/bdr:733439/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Cardiff University

14. Hand, Sadiyah. Long-term follow up of infants at high risk of asthma from a deprived community in South Wales.

Degree: md, 2015, Cardiff University

URL: http://orca.cf.ac.uk/79595/

► Asthma is a chronic respiratory disease with a prevalence that has increased worldwide over the past 40 years. Longitudinal cohort studies have been designed to… (more)

Subjects/Keywords: RJ Pediatrics

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APA (6^th Edition):

Hand, S. (2015). Long-term follow up of infants at high risk of asthma from a deprived community in South Wales. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/79595/

Chicago Manual of Style (16^th Edition):

Hand, Sadiyah. “Long-term follow up of infants at high risk of asthma from a deprived community in South Wales.” 2015. Doctoral Dissertation, Cardiff University. Accessed March 04, 2021. http://orca.cf.ac.uk/79595/.

MLA Handbook (7^th Edition):

Hand, Sadiyah. “Long-term follow up of infants at high risk of asthma from a deprived community in South Wales.” 2015. Web. 04 Mar 2021.

Vancouver:

Hand S. Long-term follow up of infants at high risk of asthma from a deprived community in South Wales. [Internet] [Doctoral dissertation]. Cardiff University; 2015. [cited 2021 Mar 04]. Available from: http://orca.cf.ac.uk/79595/.

Council of Science Editors:

Hand S. Long-term follow up of infants at high risk of asthma from a deprived community in South Wales. [Doctoral Dissertation]. Cardiff University; 2015. Available from: http://orca.cf.ac.uk/79595/

Cardiff University

15. Rees, Philippa. Paediatric safety in primary care: a cross-sectional mixed methods study of national incident report data.

Degree: mphil, 2015, Cardiff University

URL: http://orca.cf.ac.uk/80718/

► Primary care is responsible for the majority of children’s healthcare contact, yet there is a dearth of research into the safety of care provided to… (more)

▼ Primary care is responsible for the majority of children’s healthcare contact, yet there is a dearth of research into the safety of care provided to children in this setting. Confidential Enquiries highlight the need for improved vaccination, better recognition of seriously unwell children, and improved management of children with chronic conditions. This thesis therefore aimed to explore deficiencies in the vaccination process and in the primary care provided to ‘unwell’ children. A cross-sectional mixed methods study of paediatric safety incidents involving vaccination or ‘unwell’ children, from primary care between 2002-2013 was conducted. The free-texts of 3913 reports submitted to the National Reporting and Learning System were classified to describe: incident types, contributory factors, incident outcomes, and severity of harm outcomes. Additionally, a literature review was conducted to identify potential interventions to address problem areas identified. Key vaccination-related failures included vaccination with the wrong number of doses, at the wrong time, or with the wrong vaccine. Documentation failures and staff mistakes frequently underpinned these incidents, and vulnerable groups appeared more prone to incidents. Key incidents involving ‘unwell’ children were related to: medication provision; and failures of diagnosis, assessment, referral, and communication, primarily related to telephone assessments. Medication errors were often the result of staff mistakes and failing to follow protocols. Incidents related to telephone assessment of ‘unwell’ children were often precipitated by protocol problems such as failing to assess children using the appropriate protocol. The findings presented in this thesis provide an overview of paediatric safety problems in primary care, in addition to offering recommendations for improvement. Example recommendations include building IT infrastructure to address vaccination-related documentation discrepancies; electronic transmission of prescriptions to community pharmacies to reduce dispensing errors; and adapting clinical decision software to improve paediatric telephone-based assessments. The hypotheses generated from this work will form the basis of future work.

Subjects/Keywords: RJ Pediatrics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rees, P. (2015). Paediatric safety in primary care: a cross-sectional mixed methods study of national incident report data. (Masters Thesis). Cardiff University. Retrieved from http://orca.cf.ac.uk/80718/

Chicago Manual of Style (16^th Edition):

Rees, Philippa. “Paediatric safety in primary care: a cross-sectional mixed methods study of national incident report data.” 2015. Masters Thesis, Cardiff University. Accessed March 04, 2021. http://orca.cf.ac.uk/80718/.

MLA Handbook (7^th Edition):

Rees, Philippa. “Paediatric safety in primary care: a cross-sectional mixed methods study of national incident report data.” 2015. Web. 04 Mar 2021.

Vancouver:

Rees P. Paediatric safety in primary care: a cross-sectional mixed methods study of national incident report data. [Internet] [Masters thesis]. Cardiff University; 2015. [cited 2021 Mar 04]. Available from: http://orca.cf.ac.uk/80718/.

Council of Science Editors:

Rees P. Paediatric safety in primary care: a cross-sectional mixed methods study of national incident report data. [Masters Thesis]. Cardiff University; 2015. Available from: http://orca.cf.ac.uk/80718/

University of Glasgow

16. Nweneka, Chidi Victor. Chloroquine as a therapeutic option for mild post malaria anaemia.

Degree: PhD, 2011, University of Glasgow

URL: http://theses.gla.ac.uk/2622/

► Background: The relative importance of malaria anaemia as a cause of childhood morbidity and mortality varies between and within regions. However, malaria anaemia remains an… (more)

▼ Background: The relative importance of malaria anaemia as a cause of childhood morbidity and mortality varies between and within regions. However, malaria anaemia remains an important cause of childhood morbidity and mortality. It has been estimated that globally, severe malaria anaemia occurs 1.42 to 5.66 million times per annum and kills an estimated 190,000 to 974,000 under-5 children. Studies from different countries endemic for malaria have emphasised the importance of anaemia in malaria-associated morbidity and mortality. Most of these studies have conclusively shown that severe malaria anaemia increases the risk of death in children with malaria; and in many reports, children with severe malaria anaemia often die before blood transfusion could be commenced. In addition, blood transfusion, which is the standard management for severe malaria anaemia, apart from not being available in many rural clinics, exposes the child to transfusion related infections such as human immunodeficiency virus (HIV). Better understanding of the pathogenesis of malaria anaemia therefore will enhance its prevention and management. The pathogenesis of malaria anaemia is multifactorial and involves such mechanisms as immune and non-immune mediated haemolysis of parasitized and non-parasitized erythrocytes, bone marrow dysfunction, altered cytokine balance, nutritional deficits and interactions with common haemoglobinopathies and red cell defects such as glucose-6-phosphate dehydrogenase (G6PD) deficiency. An important component of the pathogenesis of malaria anaemia is iron delocalisation characterised by the sequestration of iron by the reticulo-endothelial tissues (the monocyte-macrophage system) as a result of malaria-induced inflammation. Iron sequestration creates a state of false iron deficiency which recovers after the inflammation has subsided. Therefore if the malaria-induced inflammation can be resolved more quickly, the degree and duration of malaria anaemia will be reduced. In addition, since the destruction of non-parasitized erythrocytes accounts for more than 90% of erythrocyte loss, use of anti-inflammatory drugs could minimize red cell loss. Chloroquine is an antimalarial with proven anti-inflammatory properties. In addition, it is cheap, safe and has been shown to reduce iron delocalisation in vitro. A proof of concept study was designed to investigate its potential use in the management of children with mild malaria anaemia. Aims and hypothesis: The goal of the study was to investigate the effect of acute and continuing administration of chloroquine on haemopoietic response after a malaria episode. My hypothesis was that the anti-inflammatory and anti-macrophageal iron-loading effects of chloroquine will enhance erythropoietic recovery after a malaria episode. Methodology: The study was designed as a randomised placebo controlled trial and was conducted over two malaria seasons. In the first year, the study consisted of four arms with a 2x2 design and only two arms in the second year. In the first year, the…

Subjects/Keywords: RJ Pediatrics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nweneka, C. V. (2011). Chloroquine as a therapeutic option for mild post malaria anaemia. (Doctoral Dissertation). University of Glasgow. Retrieved from http://theses.gla.ac.uk/2622/

Chicago Manual of Style (16^th Edition):

Nweneka, Chidi Victor. “Chloroquine as a therapeutic option for mild post malaria anaemia.” 2011. Doctoral Dissertation, University of Glasgow. Accessed March 04, 2021. http://theses.gla.ac.uk/2622/.

MLA Handbook (7^th Edition):

Nweneka, Chidi Victor. “Chloroquine as a therapeutic option for mild post malaria anaemia.” 2011. Web. 04 Mar 2021.

Vancouver:

Nweneka CV. Chloroquine as a therapeutic option for mild post malaria anaemia. [Internet] [Doctoral dissertation]. University of Glasgow; 2011. [cited 2021 Mar 04]. Available from: http://theses.gla.ac.uk/2622/.

Council of Science Editors:

Nweneka CV. Chloroquine as a therapeutic option for mild post malaria anaemia. [Doctoral Dissertation]. University of Glasgow; 2011. Available from: http://theses.gla.ac.uk/2622/

University of Glasgow

17. Mackay, Fiona. The realities of segregation through the eyes of adolescents with cystic fibrosis: a qualitative study and clinical research portfolio .

Degree: 2011, University of Glasgow

URL: http://theses.gla.ac.uk/2929/

► Introduction: The segregation of patients with Cystic Fibrosis, purposefully keeping them apart from one another, has become common practice in order to reduce infections being… (more)

▼ Introduction: The segregation of patients with Cystic Fibrosis, purposefully keeping them apart from one another, has become common practice in order to reduce infections being passed from one CF patient to another. There is sufficient medical evidence to support these measures as an effective method of preventing early deterioration of the lungs, yet, there has been virtually no research exploring the psycho-social impact of such a policy. This study aimed to fill this void and become the first study to explore segregation from the perspectives of young people with cystic fibrosis. Method: A qualitative design was used and eight young people with Cystic Fibrosis, (aged 13-15) were interviewed at The Royal Hospital for Sick Children, NHS Greater Glasgow & Clyde. Following transcription, in-depth analysis using Interpretative Phenomenological Analysis was carried out. Results: Analysis of transcripts led to the identification of three super-ordinate themes; ‘Acceptance of Source’ which refers to participants overall acceptance of being in source isolation, after weighing up the pros and cons, ‘Personal Models of CF’ which refers to both medical and psycho-social perceptions of having CF, and ‘Normalisation’ emerged through descriptions of methods used to help to them feel normal and cope with CF. It is proposed that loss of any one of these factors may have a negative impact on adjustment. Conclusions: Support was found for the practice of segregation however this is not without a psycho-social cost (i.e. loss of opportunity to openly discuss their health with others and have their experiences validated). These young people also appeared to have heightened awareness of the wider impact of the policy upon their parents. Contact with CF others was recognised by these young people as valuable. Innovative solutions are urgently required to address these potential costs. In light of this, a number of clinical recommendations have been made and areas for future research have been outlined.

Subjects/Keywords: RJ Pediatrics

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APA (6^th Edition):

Mackay, F. (2011). The realities of segregation through the eyes of adolescents with cystic fibrosis: a qualitative study and clinical research portfolio . (Thesis). University of Glasgow. Retrieved from http://theses.gla.ac.uk/2929/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mackay, Fiona. “The realities of segregation through the eyes of adolescents with cystic fibrosis: a qualitative study and clinical research portfolio .” 2011. Thesis, University of Glasgow. Accessed March 04, 2021. http://theses.gla.ac.uk/2929/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mackay, Fiona. “The realities of segregation through the eyes of adolescents with cystic fibrosis: a qualitative study and clinical research portfolio .” 2011. Web. 04 Mar 2021.

Vancouver:

Mackay F. The realities of segregation through the eyes of adolescents with cystic fibrosis: a qualitative study and clinical research portfolio . [Internet] [Thesis]. University of Glasgow; 2011. [cited 2021 Mar 04]. Available from: http://theses.gla.ac.uk/2929/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mackay F. The realities of segregation through the eyes of adolescents with cystic fibrosis: a qualitative study and clinical research portfolio . [Thesis]. University of Glasgow; 2011. Available from: http://theses.gla.ac.uk/2929/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Glasgow

18. Walker, Susan. Molecular mechanisms initiated within cyanotic and acyanotic infant myocardium during cardio-pulmonary bypass in vivo and ischemic-reperfusion injury in vitro.

Degree: PhD, 2013, University of Glasgow

URL: http://theses.gla.ac.uk/4169/

► Children with the congenital heart defect TOF require surgical repair. Their myocardium is exposed to chronic hypoxia due to insufficiently oxygenated blood shunted from the… (more)

▼ Children with the congenital heart defect TOF require surgical repair. Their myocardium is exposed to chronic hypoxia due to insufficiently oxygenated blood shunted from the right to the left side of the heart through the VSD, resulting in cyanosis. Such corrective surgery often requires the use of CPB. During these procedures the aortic clamp is applied to allow access to the heart for the surgical correction creating an ischemic environment. When the clamp is removed and blood flow returned, the heart is reperfused. This exposes the myocardium to IR injury. Super-high oxygen (O2) levels are often used in the bypass circuit after the cross-clamp is released. This means during reperfusion the myocardium is exposed to high levels of O2. This is thought to be harmful, especially to children with cyanosis pre-operatively. A growing body of evidence suggests that these high levels of O2 may be damaging to the infant myocardium but the mechanisms are not that well understood. The first aim of this project was to investigate the molecular changes that occur within the infant myocardium in the context of congenital heart disease by comparing myocardium from the cyanotic patient group (TOF patients) and acyanotic patient group (patients with sub-aortic stenosis or truncus arteriosus i.e. disorders requiring myocardial resection but where the myocardium is acyanotic) during the ischemic phase. This was performed to reflect as near to pre-operative gene expression levels as possible. This thesis focused on the expression of inflammatory mediators (TLRs) and stress proteins (HSPs). It was found that TLR4 (p=0.0303), TLR2 (p=0.0177) and HSP27 (0.0303) mRNA expression were significantly higher in the myocardium from the cyanotic patient group compared to the acyanotic patient group. This could indicate a consequence of the hypoxic environment within such myocardium. HSPs are stress proteins, which are induced upon cellular stress. The Aplein receptor (APJ) is upregulated in the heart during ischemia and IR injury and thought to be cardio- protective. Additional work was performed that investigated the protein expression of HSP27 and APJ during the ischemic phase in cyanotic and non-cyanotic TOF myocardium. This expression was compared with various measurements of cardiac function. HSP27 protein expression was significantly elevated in cyanotic myocardium pre-operatively. It was also associated with improved right ventricle function and systemic perfusion. This supports a cardio-protective effect of HSP27 in cyanotic TOF. APJ was found to be associated with 2 improved systemic perfusion when both cyanotic and non-cyanotic patient data were combined. In order to determine if stress genes (HSPs) were inducible in the infant myocardium, they were exposed to classic heavy metal inducers sodium arsenite and cadmium chloride. Of the six HSPs investigated, all were shown to be present within the ischemic myocardium. Myocardial HSP32 (p=0.0156), HSP72 (p=0.0156) and HSP90 (p=0.0156) mRNA expression were significantly increased…

Subjects/Keywords: RJ Pediatrics

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APA (6^th Edition):

Walker, S. (2013). Molecular mechanisms initiated within cyanotic and acyanotic infant myocardium during cardio-pulmonary bypass in vivo and ischemic-reperfusion injury in vitro. (Doctoral Dissertation). University of Glasgow. Retrieved from http://theses.gla.ac.uk/4169/

Chicago Manual of Style (16^th Edition):

Walker, Susan. “Molecular mechanisms initiated within cyanotic and acyanotic infant myocardium during cardio-pulmonary bypass in vivo and ischemic-reperfusion injury in vitro.” 2013. Doctoral Dissertation, University of Glasgow. Accessed March 04, 2021. http://theses.gla.ac.uk/4169/.

MLA Handbook (7^th Edition):

Walker, Susan. “Molecular mechanisms initiated within cyanotic and acyanotic infant myocardium during cardio-pulmonary bypass in vivo and ischemic-reperfusion injury in vitro.” 2013. Web. 04 Mar 2021.

Vancouver:

Walker S. Molecular mechanisms initiated within cyanotic and acyanotic infant myocardium during cardio-pulmonary bypass in vivo and ischemic-reperfusion injury in vitro. [Internet] [Doctoral dissertation]. University of Glasgow; 2013. [cited 2021 Mar 04]. Available from: http://theses.gla.ac.uk/4169/.

Council of Science Editors:

Walker S. Molecular mechanisms initiated within cyanotic and acyanotic infant myocardium during cardio-pulmonary bypass in vivo and ischemic-reperfusion injury in vitro. [Doctoral Dissertation]. University of Glasgow; 2013. Available from: http://theses.gla.ac.uk/4169/

University of Glasgow

19. El fakhri, Nagla. Effect of vitamin D supplementation on bone status, glucose homeostasis and immune function in children with vitamin D deficiency.

Degree: PhD, 2016, University of Glasgow

URL: http://theses.gla.ac.uk/7555/

► Background: Between 1961-1971 vitamin D deficiency was recognized as a public health issue in the UK, because of the lack of effective sunlight and the… (more)

▼ Background: Between 1961-1971 vitamin D deficiency was recognized as a public health issue in the UK, because of the lack of effective sunlight and the population mix [1, 2]. In recent years, health care professionals have cited evidence suggesting a re-emergence of the vitamin D deficiency linked to a number of health consequences as a concern [3-6]. Evidence from observational studies has linked low vitamin D status with impairment in glucose homeostasis and immune dysfunction [7-9]. However, interventional studies, particularly those focused on paediatric populations, have been limited and inconsistent. There is a need for detailed studies, to clarify the therapeutic benefits of vitamin D in these important clinical areas. Objective: The aims of this PhD thesis were two-fold. Firstly, to perform preliminary work assessing the association between vitamin D deficiency and bone status, glucose homeostasis and immune function, and to explore any changes in these parameters following short term vitamin D3 replacement therapy. Secondly, to assess the effectiveness of an electronic surveillance system (ScotPSU) as a tool to determine the current incidence of hospital-based presentation of childhood vitamin D deficiency in Scotland. Methods: Active surveillance was performed for a period of two years as a part of an electronic web-based surveillance programme performed by the Scottish Paediatric Surveillance Unit (ScotPSU). The validity of the system was assessed by identifying cases with profound vitamin D deficiency (in Glasgow and Edinburgh) from the regional laboratory. All clinical details were checked against those identified using the surveillance system. Thirty-seven children aged 3 months to 10 years, who had been diagnosed with vitamin D deficiency, were recruited for the bone, glucose and immunity studies over a period of 24 months. Twenty-five samples were analysed for the glucose and bone studies; of these, 18 samples were further analysed for immune study. Treatment consisted of six weeks taking 5000 IU units cholecalciferol orally once a day. At baseline and after completion of treatment, 25 hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), alkaline phosphatase (ALP), collagen type 1 cross-linked C-telopeptide (CTX), osteocalcin (OCN), calcium, phosphate, insulin, glucose, homeostasis model assessment index, estimated insulin resistance (HOMA IR), glycated hemoglobin (HbA1c), sex hormone binding globulin (SHBG), lipids profiles, T helper 1 (Th1) cytokines (interleukin-2 ( IL-2), tumor necrosis factors-alpha (TNF-α), interferon-gamma (INF-γ)), T helper 2 (Th2) cytokines (interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-6 (IL-6)), T helper 17 (Th17) cytokine (interleukin-17 (IL-17)), Regulatory T (Treg) cytokine (interleukin-10 (IL-10)) and chemokines/cytokines, linked with Th1/Th2 subset balance and/or differentiation (interleukin-8 (IL-8), interleukin-12 (IL-12), eosinophil chemotactic protein ( EOTAXIN), macrophage inflammatory proteins-1beta (MIP-1β),…

Subjects/Keywords: RJ Pediatrics

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APA (6^th Edition):

El fakhri, N. (2016). Effect of vitamin D supplementation on bone status, glucose homeostasis and immune function in children with vitamin D deficiency. (Doctoral Dissertation). University of Glasgow. Retrieved from http://theses.gla.ac.uk/7555/

Chicago Manual of Style (16^th Edition):

El fakhri, Nagla. “Effect of vitamin D supplementation on bone status, glucose homeostasis and immune function in children with vitamin D deficiency.” 2016. Doctoral Dissertation, University of Glasgow. Accessed March 04, 2021. http://theses.gla.ac.uk/7555/.

MLA Handbook (7^th Edition):

El fakhri, Nagla. “Effect of vitamin D supplementation on bone status, glucose homeostasis and immune function in children with vitamin D deficiency.” 2016. Web. 04 Mar 2021.

Vancouver:

El fakhri N. Effect of vitamin D supplementation on bone status, glucose homeostasis and immune function in children with vitamin D deficiency. [Internet] [Doctoral dissertation]. University of Glasgow; 2016. [cited 2021 Mar 04]. Available from: http://theses.gla.ac.uk/7555/.

Council of Science Editors:

El fakhri N. Effect of vitamin D supplementation on bone status, glucose homeostasis and immune function in children with vitamin D deficiency. [Doctoral Dissertation]. University of Glasgow; 2016. Available from: http://theses.gla.ac.uk/7555/

University of Glasgow

20. Milani, Shamsi Afiat. Evaluation of a new infant nutrition screening tool (Infant Paediatric Yorkhill Malnutrition Score) and its applicability in Iran as compared to the United Kingdom.

Degree: PhD, 2016, University of Glasgow

URL: http://theses.gla.ac.uk/7298/

► A high prevalence of malnutrition has been reported in paediatric inpatients both in developed and developing countries, using various methodology and criteria. According to national… (more)

▼ A high prevalence of malnutrition has been reported in paediatric inpatients both in developed and developing countries, using various methodology and criteria. According to national and international guidelines, all inpatients should be screened for risk of malnutrition on admission using a validated screening tool. However, because of the lack of universally accepted definition for malnutrition, there is no consensus on the measures and methods to use for nutritional screening. There is controversy concerning the validity, reliability and practicality of existing paediatric nutrition screening tools. Moreover, current paediatric screening tools have not been designed and validated for infants. The study aimed to: 1) Validate a novel malnutrition screening scheme for infants - the Infant Paediatric Yorkhill Malnutrition Score (iPYMS) and compare its utility in different hospital settings, in UK and Middle East, Iran. 2) Compare the usefulness of various anthropometric measures to predict malnutrition in infants. 3) Determine the factors that correlated with malnutrition in hospitalised infants. 4) Explore the use of body composition measures in sick infants. The Paediatric Yorkhill Malnutrition Score (PYMS) had already been developed in Glasgow for use in children admitted to hospital. It utilized four elements that were reported as recognized predictors of the past, present or future nutrition risk. An audit was carried out at the beginning of the PhD course and aimed to evaluate the effect of PYMS on collection of anthropometric measurements in the wards. Findings suggested that introduction of a screening tool improved the acquisition of anthropometry by nursing staff, but their utilization by medical staff remained poor. Method: The Infant Paediatric Yorkhill Malnutrition Score (iPYMS) was developed by the research team. The score encompasses 4 rated steps that similar to those used for older children: weight <2nd and 9thcentile was used as opposed to BMI, and 3 elements concerning the history of nutritional issues. A score of 1 classifies a patient at medium risk and ≥2 or ≥3 indicates high risk. Infants were studied at admission to two tertiary children's hospital, 210 (0-12 months) in Glasgow, UK and 187 (1-12 months) in Tabriz, Iran. Convenience sampling was used to recruit equal number of patients in each risk group. Four researchers recruited the samples for the UK cohort and one for the Iran cohort. The diagnostic accuracy and validity of iPYMS in both cohorts were assessed by comparing the iPYMS nutritional risk with the Paediatric Subjective Global Nutritional Assessment (SGNA) that determine malnutrition risk and mean skinfolds z-scores (triceps and subscapular) below <-2SD as the benchmark for low fat stores and acute/chronic malnutrition. Discriminant validity was assessed using body composition and anthropometry measurements, with the hypothesis that infants at high risk of malnutrition will have lower fat and possibly lean mass compared with those at low risk. Results: More…

Subjects/Keywords: RJ Pediatrics

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APA (6^th Edition):

Milani, S. A. (2016). Evaluation of a new infant nutrition screening tool (Infant Paediatric Yorkhill Malnutrition Score) and its applicability in Iran as compared to the United Kingdom. (Doctoral Dissertation). University of Glasgow. Retrieved from http://theses.gla.ac.uk/7298/

Chicago Manual of Style (16^th Edition):

Milani, Shamsi Afiat. “Evaluation of a new infant nutrition screening tool (Infant Paediatric Yorkhill Malnutrition Score) and its applicability in Iran as compared to the United Kingdom.” 2016. Doctoral Dissertation, University of Glasgow. Accessed March 04, 2021. http://theses.gla.ac.uk/7298/.

MLA Handbook (7^th Edition):

Milani, Shamsi Afiat. “Evaluation of a new infant nutrition screening tool (Infant Paediatric Yorkhill Malnutrition Score) and its applicability in Iran as compared to the United Kingdom.” 2016. Web. 04 Mar 2021.

Vancouver:

Milani SA. Evaluation of a new infant nutrition screening tool (Infant Paediatric Yorkhill Malnutrition Score) and its applicability in Iran as compared to the United Kingdom. [Internet] [Doctoral dissertation]. University of Glasgow; 2016. [cited 2021 Mar 04]. Available from: http://theses.gla.ac.uk/7298/.

Council of Science Editors:

Milani SA. Evaluation of a new infant nutrition screening tool (Infant Paediatric Yorkhill Malnutrition Score) and its applicability in Iran as compared to the United Kingdom. [Doctoral Dissertation]. University of Glasgow; 2016. Available from: http://theses.gla.ac.uk/7298/

University of Glasgow

21. Macintyre-Beon, Catriona. Cerebral visual impairment in children born prematurely.

Degree: 2015, University of Glasgow

URL: http://theses.gla.ac.uk/6216/

► Cerebral visual impairment (CVI) is the commonest cause of impaired vision in childhood. Prematurely born children are at significant risk of damage to the brain… (more)

Subjects/Keywords: RJ Pediatrics

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APA (6^th Edition):

Macintyre-Beon, C. (2015). Cerebral visual impairment in children born prematurely. (Thesis). University of Glasgow. Retrieved from http://theses.gla.ac.uk/6216/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Macintyre-Beon, Catriona. “Cerebral visual impairment in children born prematurely.” 2015. Thesis, University of Glasgow. Accessed March 04, 2021. http://theses.gla.ac.uk/6216/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Macintyre-Beon, Catriona. “Cerebral visual impairment in children born prematurely.” 2015. Web. 04 Mar 2021.

Vancouver:

Macintyre-Beon C. Cerebral visual impairment in children born prematurely. [Internet] [Thesis]. University of Glasgow; 2015. [cited 2021 Mar 04]. Available from: http://theses.gla.ac.uk/6216/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Macintyre-Beon C. Cerebral visual impairment in children born prematurely. [Thesis]. University of Glasgow; 2015. Available from: http://theses.gla.ac.uk/6216/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Glasgow

22. Todd, Maureen Ann. Study of the prevalence of musculoskeletal abnormalities, particularly arthritis, in children with Down’s syndrome in the Glasgow population.

Degree: 2015, University of Glasgow

URL: http://theses.gla.ac.uk/6225/

► Down’s syndrome (DS) is associated with multiple musculoskeletal (MSK) features, including hypermobility and inflammatory arthritis. MSK disorders are not included in the screening programme for… (more)

▼ Down’s syndrome (DS) is associated with multiple musculoskeletal (MSK) features, including hypermobility and inflammatory arthritis. MSK disorders are not included in the screening programme for these children and correct diagnosis of MSK problems can be missed or delayed. This study aimed to identify and examine the population of children with DS resident in Greater Glasgow to determine the frequency of musculoskeletal disorders and the levels of associated physical disability, particularly hypermobility, podiatric disorders, arthritis and obesity levels. Between Jan 2011-2012 147 children with DS, aged between two and sixteen years and resident in Greater Glasgow and Clyde Health Board by postcode were identified from the Glasgow Thyroid and community paediatricians’ register. They were invited to a single study visit encompassing musculoskeletal and podiatric examinations, anthropometric measurements and completion of study questionnaires. Focus groups were carried out to establish knowledge of MSK disorders in professionals likely to encounter this population. Seventy three children participated in the study. A high level of hypermobility was identified, characterized by predominance in the weight bearing joints of the lower limbs, especially hips (77%), ankles (56%) and feet (59%). Standard measures of hypermobility failed to identify the extent and severity of hypermobility in these children, identifying only 15% of children as having hypermobility syndrome. No new cases of arthritis were identified in the study cohort. Families reported a lack of expression of pain. Ten percent of the cohort were obese, compared to 20% in the UK cohort from which DS growth charts are derived. Focus groups identified concerns from professionals about knowledge and skills in identifying musculoskeletal problems in these children, and challenges in ascribing an appropriate diagnosis. This study identified barriers to care for a range of MSK pathologies in DS which targeted education and disease specific structuring of services could address. Rheumatologists found that expectations for MSK functioning in this population were low. Education focusing on the recognition and accurate assessment of altered or deteriorating MSK function is required. Severe and extensive hypermobility combined with altered expression of pain were found in this population, adding diagnostic challenges. Current MSK examination tools for hypermobility and hypotonia did not perform well in this population. Current health screening structures, the education and expectations of those providing health screening were identified as further barriers to MSK diagnosis. Facilitating early and accurate MSK diagnosis through the development of MSK examination tools, targeted education and structuring services for this population are important for the MSK and broader health of these children.

Subjects/Keywords: RJ Pediatrics

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APA (6^th Edition):

Todd, M. A. (2015). Study of the prevalence of musculoskeletal abnormalities, particularly arthritis, in children with Down’s syndrome in the Glasgow population. (Thesis). University of Glasgow. Retrieved from http://theses.gla.ac.uk/6225/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Todd, Maureen Ann. “Study of the prevalence of musculoskeletal abnormalities, particularly arthritis, in children with Down’s syndrome in the Glasgow population.” 2015. Thesis, University of Glasgow. Accessed March 04, 2021. http://theses.gla.ac.uk/6225/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Todd, Maureen Ann. “Study of the prevalence of musculoskeletal abnormalities, particularly arthritis, in children with Down’s syndrome in the Glasgow population.” 2015. Web. 04 Mar 2021.

Vancouver:

Todd MA. Study of the prevalence of musculoskeletal abnormalities, particularly arthritis, in children with Down’s syndrome in the Glasgow population. [Internet] [Thesis]. University of Glasgow; 2015. [cited 2021 Mar 04]. Available from: http://theses.gla.ac.uk/6225/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Todd MA. Study of the prevalence of musculoskeletal abnormalities, particularly arthritis, in children with Down’s syndrome in the Glasgow population. [Thesis]. University of Glasgow; 2015. Available from: http://theses.gla.ac.uk/6225/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town

23. Scragg, Joan Noelle. Amoebic liver abscess in Natal African children.

Degree: Image, Paediatrics and Child Health, 1961, University of Cape Town

URL: http://hdl.handle.net/11427/26309

Subjects/Keywords: Pediatrics

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APA (6^th Edition):

Scragg, J. N. (1961). Amoebic liver abscess in Natal African children. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/26309

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Scragg, Joan Noelle. “Amoebic liver abscess in Natal African children.” 1961. Thesis, University of Cape Town. Accessed March 04, 2021. http://hdl.handle.net/11427/26309.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Scragg, Joan Noelle. “Amoebic liver abscess in Natal African children.” 1961. Web. 04 Mar 2021.

Vancouver:

Scragg JN. Amoebic liver abscess in Natal African children. [Internet] [Thesis]. University of Cape Town; 1961. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11427/26309.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Scragg JN. Amoebic liver abscess in Natal African children. [Thesis]. University of Cape Town; 1961. Available from: http://hdl.handle.net/11427/26309

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Lund

24. Winberg, Hans. Hypospadias Surgery. Outcome and Complications.

Degree: 2020, University of Lund

URL: https://lup.lub.lu.se/record/641e8257-90b2-44d2-a0ff-67b19570d53a ; https://portal.research.lu.se/ws/files/78487169/Hans_Winberg_web.pdf

Subjects/Keywords: Pediatrics

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APA (6^th Edition):

Winberg, H. (2020). Hypospadias Surgery. Outcome and Complications. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/641e8257-90b2-44d2-a0ff-67b19570d53a ; https://portal.research.lu.se/ws/files/78487169/Hans_Winberg_web.pdf

Chicago Manual of Style (16^th Edition):

Winberg, Hans. “Hypospadias Surgery. Outcome and Complications.” 2020. Doctoral Dissertation, University of Lund. Accessed March 04, 2021. https://lup.lub.lu.se/record/641e8257-90b2-44d2-a0ff-67b19570d53a ; https://portal.research.lu.se/ws/files/78487169/Hans_Winberg_web.pdf.

MLA Handbook (7^th Edition):

Winberg, Hans. “Hypospadias Surgery. Outcome and Complications.” 2020. Web. 04 Mar 2021.

Vancouver:

Winberg H. Hypospadias Surgery. Outcome and Complications. [Internet] [Doctoral dissertation]. University of Lund; 2020. [cited 2021 Mar 04]. Available from: https://lup.lub.lu.se/record/641e8257-90b2-44d2-a0ff-67b19570d53a ; https://portal.research.lu.se/ws/files/78487169/Hans_Winberg_web.pdf.

Council of Science Editors:

Winberg H. Hypospadias Surgery. Outcome and Complications. [Doctoral Dissertation]. University of Lund; 2020. Available from: https://lup.lub.lu.se/record/641e8257-90b2-44d2-a0ff-67b19570d53a ; https://portal.research.lu.se/ws/files/78487169/Hans_Winberg_web.pdf

University of Glasgow

25. Symonds, Joseph Daniel. The potential impact of genotype-driven precision medicine for children with epilepsy.

Degree: PhD, 2019, University of Glasgow

URL: http://theses.gla.ac.uk/77899/

► Introduction: The development and application of next generation sequencing (NGS) technology has led to an exponential rise in the number of genes and genetic variants… (more)

▼ Introduction: The development and application of next generation sequencing (NGS) technology has led to an exponential rise in the number of genes and genetic variants associated with epilepsy. The detection of highly penetrant and damaging variants in some patients can be sufficient to provide an adequate explanation for the entire disease process. Particularly high yields from such diagnostic genetic testing are observed in cohorts of children who present with early onset seizures. Obtaining a genetic diagnosis can be helpful to families in terms of informing further reproductive decisions, providing answers, and preventing further costly investigations. Evidence is emerging that certain anti-epileptic therapies may be more effective than others in specific genetic epilepsies. Aim: The aim of this thesis is to explore the potential for genetically-guided therapy for children with epilepsy. This will be primarily achieved through describing the epidemiology of the genetic epilepsies of childhood, and through researching the evidence-base for gene-specific therapy. Methods: This is a mixed methods study. In chapter 5 The epidemiology of early childhood genetic epilepsy is described using a prospective whole Scotland population based national cohort. This includes all children presenting under three years of age presenting with new onset epilepsy over a defined time period (May 2014 to May 2017, n =315). These children were tested on a panel of 104 epilepsy-associated genes. In chapter 6 the potential for Whole Genome Sequencing (WGS) to identify further genetic diagnoses in deeply-phenotyped families is then explored in a separate cohort of children presenting in the West of Scotland with severe or drug-resistant epilepsy (n = 79). In chapter 4, a systematic review approach is used to identify any epilepsy-associated genes for which evidence exists to support a specific therapeutic approach. The results from this review considered in both cohorts. Chapter 7 describes a new genetic epilepsy due to SMC1A truncation and explores the potential for specific therapy in this condition. Chapter 8 evaluates whether sub-analysis of genetic data within a randomised controlled trial can be harnessed to identify patients most likely to respond to therapy. Key results: Epilepsy affects 1 per 383 children before their third birthday. In 22% of these children a single-gene cause can be identified. For 80% per cent of single-gene diagnoses in this group of patients there is some evidence to support a specific therapeutic approach. Evidence is variable in quality and nature. Between 1 in 2,000 and 1 in 2,300 of all children born are likely to have a genetically determined epilepsy for which there is currently available some evidence for a specific treatment choice. The majority of currently achievable genetic diagnoses are concentrated in a small number of genes, with genetic diagnoses beyond the 20 most common being extremely individually rare. Evidence to support specific therapeutic approaches is generally…

Subjects/Keywords: RJ Pediatrics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Symonds, J. D. (2019). The potential impact of genotype-driven precision medicine for children with epilepsy. (Doctoral Dissertation). University of Glasgow. Retrieved from http://theses.gla.ac.uk/77899/

Chicago Manual of Style (16^th Edition):

Symonds, Joseph Daniel. “The potential impact of genotype-driven precision medicine for children with epilepsy.” 2019. Doctoral Dissertation, University of Glasgow. Accessed March 04, 2021. http://theses.gla.ac.uk/77899/.

MLA Handbook (7^th Edition):

Symonds, Joseph Daniel. “The potential impact of genotype-driven precision medicine for children with epilepsy.” 2019. Web. 04 Mar 2021.

Vancouver:

Symonds JD. The potential impact of genotype-driven precision medicine for children with epilepsy. [Internet] [Doctoral dissertation]. University of Glasgow; 2019. [cited 2021 Mar 04]. Available from: http://theses.gla.ac.uk/77899/.

Council of Science Editors:

Symonds JD. The potential impact of genotype-driven precision medicine for children with epilepsy. [Doctoral Dissertation]. University of Glasgow; 2019. Available from: http://theses.gla.ac.uk/77899/

University of Minnesota

26. Taylor, Rood. Hunger in the Infant.

Degree: PhD, Pediatrics, 1917, University of Minnesota

URL: http://hdl.handle.net/11299/178044

Subjects/Keywords: Pediatrics

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APA (6^th Edition):

Taylor, R. (1917). Hunger in the Infant. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/178044

Chicago Manual of Style (16^th Edition):

Taylor, Rood. “Hunger in the Infant.” 1917. Doctoral Dissertation, University of Minnesota. Accessed March 04, 2021. http://hdl.handle.net/11299/178044.

MLA Handbook (7^th Edition):

Taylor, Rood. “Hunger in the Infant.” 1917. Web. 04 Mar 2021.

Vancouver:

Taylor R. Hunger in the Infant. [Internet] [Doctoral dissertation]. University of Minnesota; 1917. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11299/178044.

Council of Science Editors:

Taylor R. Hunger in the Infant. [Doctoral Dissertation]. University of Minnesota; 1917. Available from: http://hdl.handle.net/11299/178044

University of Minnesota

27. Stewart, Chester A. The Vital Capacity of the Lungs of Children in Health and Disease.

Degree: PhD, Pediatrics, 1921, University of Minnesota

URL: http://hdl.handle.net/11299/178090

Subjects/Keywords: Pediatrics

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APA (6^th Edition):

Stewart, C. A. (1921). The Vital Capacity of the Lungs of Children in Health and Disease. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/178090

Chicago Manual of Style (16^th Edition):

Stewart, Chester A. “The Vital Capacity of the Lungs of Children in Health and Disease.” 1921. Doctoral Dissertation, University of Minnesota. Accessed March 04, 2021. http://hdl.handle.net/11299/178090.

MLA Handbook (7^th Edition):

Stewart, Chester A. “The Vital Capacity of the Lungs of Children in Health and Disease.” 1921. Web. 04 Mar 2021.

Vancouver:

Stewart CA. The Vital Capacity of the Lungs of Children in Health and Disease. [Internet] [Doctoral dissertation]. University of Minnesota; 1921. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11299/178090.

Council of Science Editors:

Stewart CA. The Vital Capacity of the Lungs of Children in Health and Disease. [Doctoral Dissertation]. University of Minnesota; 1921. Available from: http://hdl.handle.net/11299/178090

University of Minnesota

28. Lippman, Hyman Shalit. The Blood in the Newborn Period.

Degree: PhD, Pediatrics, 1922, University of Minnesota

URL: http://hdl.handle.net/11299/178107

Subjects/Keywords: Pediatrics

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lippman, H. S. (1922). The Blood in the Newborn Period. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/178107

Chicago Manual of Style (16^th Edition):

Lippman, Hyman Shalit. “The Blood in the Newborn Period.” 1922. Doctoral Dissertation, University of Minnesota. Accessed March 04, 2021. http://hdl.handle.net/11299/178107.

MLA Handbook (7^th Edition):

Lippman, Hyman Shalit. “The Blood in the Newborn Period.” 1922. Web. 04 Mar 2021.

Vancouver:

Lippman HS. The Blood in the Newborn Period. [Internet] [Doctoral dissertation]. University of Minnesota; 1922. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11299/178107.

Council of Science Editors:

Lippman HS. The Blood in the Newborn Period. [Doctoral Dissertation]. University of Minnesota; 1922. Available from: http://hdl.handle.net/11299/178107

Texas Tech University

29. Robison, Jamie. A children's hospital.

Degree: 1956, Texas Tech University

URL: http://hdl.handle.net/2346/50490

Subjects/Keywords: Pediatrics

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Robison, J. (1956). A children's hospital. (Thesis). Texas Tech University. Retrieved from http://hdl.handle.net/2346/50490

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Robison, Jamie. “A children's hospital.” 1956. Thesis, Texas Tech University. Accessed March 04, 2021. http://hdl.handle.net/2346/50490.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Robison, Jamie. “A children's hospital.” 1956. Web. 04 Mar 2021.

Vancouver:

Robison J. A children's hospital. [Internet] [Thesis]. Texas Tech University; 1956. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2346/50490.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Robison J. A children's hospital. [Thesis]. Texas Tech University; 1956. Available from: http://hdl.handle.net/2346/50490

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Birmingham

30. Knowles, Gemma. Ethnic differences in physical activity, dietary intake, obesity and blood pressure among young children in the UK .

Degree: d_ph, College of Medical & Dental Sciences, 2015, University of Birmingham

URL: http://etheses.bham.ac.uk//id/eprint/5960/

► Introduction: Early-life differences in cardiovascular risk factors could contribute to ethnic differences in cardiometabolic disease in adulthood. The aim of this thesis was to investigate… (more)

Subjects/Keywords: RJ Pediatrics

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Knowles, G. (2015). Ethnic differences in physical activity, dietary intake, obesity and blood pressure among young children in the UK . (Thesis). University of Birmingham. Retrieved from http://etheses.bham.ac.uk//id/eprint/5960/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Knowles, Gemma. “Ethnic differences in physical activity, dietary intake, obesity and blood pressure among young children in the UK .” 2015. Thesis, University of Birmingham. Accessed March 04, 2021. http://etheses.bham.ac.uk//id/eprint/5960/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Knowles, Gemma. “Ethnic differences in physical activity, dietary intake, obesity and blood pressure among young children in the UK .” 2015. Web. 04 Mar 2021.

Vancouver:

Knowles G. Ethnic differences in physical activity, dietary intake, obesity and blood pressure among young children in the UK . [Internet] [Thesis]. University of Birmingham; 2015. [cited 2021 Mar 04]. Available from: http://etheses.bham.ac.uk//id/eprint/5960/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Knowles G. Ethnic differences in physical activity, dietary intake, obesity and blood pressure among young children in the UK . [Thesis]. University of Birmingham; 2015. Available from: http://etheses.bham.ac.uk//id/eprint/5960/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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