subject:(PYODERMA)

University of Pretoria

1. [No author]. Antimicrobial susceptibility profiles of Staphylococcus intermedius isolates from clinical cases of canine pyoderma in South Africa .

Degree: 2012, University of Pretoria

URL: http://upetd.up.ac.za/thesis/available/etd-05242012-171645/

► Successful treatment of canine pyoderma has become increasingly difficult due to the development of antimicrobial resistance and recurrence of infection. The development and spread of… (more)

▼ Successful treatment of canine pyoderma has become increasingly difficult due to the development of antimicrobial resistance and recurrence of infection. The development and spread of antimicrobial resistance has major implications because treatment failures have been associated with increased mortality, morbidity and costs related to disease. All canine skin samples submitted to Vetdiagnostix Veterinary Pathology Services for microbiological culture and sensitivity between January 2007 and June 2010, from which Staphylococcus intermedius was isolated, were selected for this investigation. A total of 319 samples from dogs of various ages, sexes and breeds from various locations throughout South Africa were obtained. In addition to the antimicrobial susceptibility data, data relating to dog signalment (age, gender, breed), case history and any other aspects of the history provided e.g. diagnosis, sample type and geographical location of the patient were collected. The number of skin samples yielding Staphylococcus intermedius was high in dogs up to the age of 6 years and, then decreased with only a few cases in dogs aged 11 years or older. The distribution of samples collected in 2010 was unusual in that there were two peaks, one in dogs two years old or less and one in 6 to 9-year-old dogs. With the exception of skin samples taken in 2008, a high percentage of dogs were under the age of one year old. 2008 had a lower percentage of affected dogs less than one year of age compared to the other years. Staphylococcal pyoderma is more common in dogs below the age of five years. Dogs above this age are less likely to contract this condition. The genders tended to be equally distributed throughout the years, with almost equal proportions of affected males and females present. The Bull Terrier types and Shepherd types were grouped separately as they were over-represented and are known to be prone to pyoderma. Large short haired dogs were consistently worse affected throughout the years sampled, followed by the Bull Terrier types. In 2010, small short haired breeds were worse affected compared to the numbers between 2007 and 2009. The monthly distribution, with the exception of 2009, tended to be consistent throughout the years. The unusual temporal distribution in 2009 could be associated with a general distribution in the number of samples compared to the other years sampled. Samples tended to be mainly from practices located in the KwaZulu-Natal province of South Africa. This is most likely due to the fact that the laboratory is located in this province, with a courier network that arranges collection from these practices. Practices in other regions send their samples to the laboratory via private courier companies and the South African Post Office. Antimicrobial resistance of S. intermedius was greatest to ampicillin followed by tetracycline and then potentiated sulphonamides. The results also showed that, in general, antimicrobial resistance was low. Very few methicillin resistant isolates were detected. Temporal trends… Advisors/Committee Members: Prof M van Vuuren (advisor).

Subjects/Keywords: Staphylococcus intermedius; Canine pyoderma; South Africa; UCTD

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APA (6^th Edition):

author], [. (2012). Antimicrobial susceptibility profiles of Staphylococcus intermedius isolates from clinical cases of canine pyoderma in South Africa . (Masters Thesis). University of Pretoria. Retrieved from http://upetd.up.ac.za/thesis/available/etd-05242012-171645/

Chicago Manual of Style (16^th Edition):

author], [No. “Antimicrobial susceptibility profiles of Staphylococcus intermedius isolates from clinical cases of canine pyoderma in South Africa .” 2012. Masters Thesis, University of Pretoria. Accessed January 19, 2021. http://upetd.up.ac.za/thesis/available/etd-05242012-171645/.

MLA Handbook (7^th Edition):

author], [No. “Antimicrobial susceptibility profiles of Staphylococcus intermedius isolates from clinical cases of canine pyoderma in South Africa .” 2012. Web. 19 Jan 2021.

Vancouver:

author] [. Antimicrobial susceptibility profiles of Staphylococcus intermedius isolates from clinical cases of canine pyoderma in South Africa . [Internet] [Masters thesis]. University of Pretoria; 2012. [cited 2021 Jan 19]. Available from: http://upetd.up.ac.za/thesis/available/etd-05242012-171645/.

Council of Science Editors:

author] [. Antimicrobial susceptibility profiles of Staphylococcus intermedius isolates from clinical cases of canine pyoderma in South Africa . [Masters Thesis]. University of Pretoria; 2012. Available from: http://upetd.up.ac.za/thesis/available/etd-05242012-171645/

Texas A&M University

2. Gold, Randi. Carriage of Virulence Factors and Antimicrobial Resistance Genes in Staphylococcus pseudintermedius from Dogs.

Degree: PhD, Veterinary Microbiology, 2015, Texas A&M University

URL: http://hdl.handle.net/1969.1/155019

► Staphylococcus pseudintermedius is the most common microorganism isolated from canine pyoderma and opportunistic infections. Prevalence of methicillin-resistant S. pseudintermedius (MRSP) has increased and multi-drug resistance… (more)

▼ Staphylococcus pseudintermedius is the most common microorganism isolated from canine pyoderma and opportunistic infections. Prevalence of methicillin-resistant S. pseudintermedius (MRSP) has increased and multi-drug resistance has become common. A total of 734 S. pseudintermedius isolates collected from dogs presented to the Veterinary Medical Teaching Hospital from 2007 to 2012 were studied. Isolates were analyzed for antimicrobial resistance and virulence gene carriage. With the emergence of methicillin resistance, veterinarians have begun to use antimicrobials such as amikacin, to treat life-threatening MRSP infections. The most widespread mechanism of amikacin resistance is drug inactivation by aminoglycoside modifying enzymes (AMEs). The most prevalent gene detected here was aph(3′)- IIIa found in 75% (24/32) of isolates followed by aac(6′)/aph(2′′) and ant(4′)-Ia in 12% (4/32) and 3% (1/32), respectively. There was a significant association between amikacin and methicillin resistance. Since AMEs can be transferred from one bacteria to another, amikacin resistance may represent a new nosocomial and zoonotic threat. Clindamycin is an alternative to β-lactam antimicrobial therapy for canine pyoderma. Inducible and constitutive resistance to clindamycin can occur. Approximately forty erm genes encoding methylases involved in clindamycin resistance have been reported, with ermB most commonly found among S. pseudintermedius. We found eight of 608 isolates tested, positive for inducible clindamycin resistance by D-test and PCR detection of ermB. A vaccine against staphylococcal pyoderma would reduce the reliance on antimicrobial drugs. Staphylococcal cell-wall associated proteins (CWAPs) involved in colonization of the host are attractive potential vaccine targets. Eighteen CWAPs encoded by sps genes have been described in S. pseudintermedius; however, four vary in occurrence. Isolates were analyzed by polymerase chain reaction (PCR) for the presence of mecA, SCCmec type I-VI, and spsF, spsO, spsP, and spsQ. There was a significant association between methicillin resistance and carriage of spsP and spsQ. spsP and spsQ may be viable vaccine targets. Advisors/Committee Members: Lawhon, Sara (advisor), Cohen, Noah (committee member), Rodrigues, Aline (committee member), Fajt, Virginia (committee member), Patterson, Adam (committee member).

Subjects/Keywords: staphylococcus pseudintermedius; pyoderma; methicillin-resistant; amikacin resistance; inducible clindamycin resistance

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gold, R. (2015). Carriage of Virulence Factors and Antimicrobial Resistance Genes in Staphylococcus pseudintermedius from Dogs. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/155019

Chicago Manual of Style (16^th Edition):

Gold, Randi. “Carriage of Virulence Factors and Antimicrobial Resistance Genes in Staphylococcus pseudintermedius from Dogs.” 2015. Doctoral Dissertation, Texas A&M University. Accessed January 19, 2021. http://hdl.handle.net/1969.1/155019.

MLA Handbook (7^th Edition):

Gold, Randi. “Carriage of Virulence Factors and Antimicrobial Resistance Genes in Staphylococcus pseudintermedius from Dogs.” 2015. Web. 19 Jan 2021.

Vancouver:

Gold R. Carriage of Virulence Factors and Antimicrobial Resistance Genes in Staphylococcus pseudintermedius from Dogs. [Internet] [Doctoral dissertation]. Texas A&M University; 2015. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1969.1/155019.

Council of Science Editors:

Gold R. Carriage of Virulence Factors and Antimicrobial Resistance Genes in Staphylococcus pseudintermedius from Dogs. [Doctoral Dissertation]. Texas A&M University; 2015. Available from: http://hdl.handle.net/1969.1/155019

University of Pretoria

3. Blunt, Catherine Ann. Antimicrobial susceptibility profiles of Staphylococcus intermedius isolates from clinical cases of canine pyoderma in South Africa.

Degree: Veterinary Tropical Diseases, 2012, University of Pretoria

URL: http://hdl.handle.net/2263/24953

► Successful treatment of canine pyoderma has become increasingly difficult due to the development of antimicrobial resistance and recurrence of infection. The development and spread of… (more)

▼ Successful treatment of canine pyoderma has become increasingly difficult due to the development of antimicrobial resistance and recurrence of infection. The development and spread of antimicrobial resistance has major implications because treatment failures have been associated with increased mortality, morbidity and costs related to disease. All canine skin samples submitted to Vetdiagnostix Veterinary Pathology Services for microbiological culture and sensitivity between January 2007 and June 2010, from which Staphylococcus intermedius was isolated, were selected for this investigation. A total of 319 samples from dogs of various ages, sexes and breeds from various locations throughout South Africa were obtained. In addition to the antimicrobial susceptibility data, data relating to dog signalment (age, gender, breed), case history and any other aspects of the history provided e.g. diagnosis, sample type and geographical location of the patient were collected. The number of skin samples yielding Staphylococcus intermedius was high in dogs up to the age of 6 years and, then decreased with only a few cases in dogs aged 11 years or older. The distribution of samples collected in 2010 was unusual in that there were two peaks, one in dogs two years old or less and one in 6 to 9-year-old dogs. With the exception of skin samples taken in 2008, a high percentage of dogs were under the age of one year old. 2008 had a lower percentage of affected dogs less than one year of age compared to the other years. Staphylococcal pyoderma is more common in dogs below the age of five years. Dogs above this age are less likely to contract this condition. The genders tended to be equally distributed throughout the years, with almost equal proportions of affected males and females present. The Bull Terrier types and Shepherd types were grouped separately as they were over-represented and are known to be prone to pyoderma. Large short haired dogs were consistently worse affected throughout the years sampled, followed by the Bull Terrier types. In 2010, small short haired breeds were worse affected compared to the numbers between 2007 and 2009. The monthly distribution, with the exception of 2009, tended to be consistent throughout the years. The unusual temporal distribution in 2009 could be associated with a general distribution in the number of samples compared to the other years sampled. Samples tended to be mainly from practices located in the KwaZulu-Natal province of South Africa. This is most likely due to the fact that the laboratory is located in this province, with a courier network that arranges collection from these practices. Practices in other regions send their samples to the laboratory via private courier companies and the South African Post Office. Antimicrobial resistance of S. intermedius was greatest to ampicillin followed by tetracycline and then potentiated sulphonamides. The results also showed that, in general, antimicrobial resistance was low. Very few methicillin resistant isolates were detected. Temporal trends… Advisors/Committee Members: Van Vuuren, Moritz (advisor).

Subjects/Keywords: Staphylococcus intermedius; Canine pyoderma; South Africa; UCTD; Dogs – Diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Blunt, C. A. (2012). Antimicrobial susceptibility profiles of Staphylococcus intermedius isolates from clinical cases of canine pyoderma in South Africa. (Masters Thesis). University of Pretoria. Retrieved from http://hdl.handle.net/2263/24953

Chicago Manual of Style (16^th Edition):

Blunt, Catherine Ann. “Antimicrobial susceptibility profiles of Staphylococcus intermedius isolates from clinical cases of canine pyoderma in South Africa.” 2012. Masters Thesis, University of Pretoria. Accessed January 19, 2021. http://hdl.handle.net/2263/24953.

MLA Handbook (7^th Edition):

Blunt, Catherine Ann. “Antimicrobial susceptibility profiles of Staphylococcus intermedius isolates from clinical cases of canine pyoderma in South Africa.” 2012. Web. 19 Jan 2021.

Vancouver:

Blunt CA. Antimicrobial susceptibility profiles of Staphylococcus intermedius isolates from clinical cases of canine pyoderma in South Africa. [Internet] [Masters thesis]. University of Pretoria; 2012. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2263/24953.

Council of Science Editors:

Blunt CA. Antimicrobial susceptibility profiles of Staphylococcus intermedius isolates from clinical cases of canine pyoderma in South Africa. [Masters Thesis]. University of Pretoria; 2012. Available from: http://hdl.handle.net/2263/24953

University of Edinburgh

4. Bannoehr, Jeanette. Molecular population and colonisation factor analysis of the Staphylococcus intermedius group.

Degree: PhD, 2010, University of Edinburgh

URL: http://hdl.handle.net/1842/5716

► The Gram-positive bacterium Staphylococcus intermedius is regarded as the major cause of canine pyoderma, a common skin infection of dogs. However, despite its clinical importance,… (more)

▼ The Gram-positive bacterium Staphylococcus intermedius is regarded as the major cause of canine pyoderma, a common skin infection of dogs. However, despite its clinical importance, the population genetic structure of S. intermedius is poorly understood. The current study examined the population genetic structure of S. intermedius using a multilocus DNA sequencing approach. A collection of 99 isolates phenotypically identified as S. intermedius and originating from a broad array of animal hosts in several different countries was investigated. Phylogenetic analysis indicated that the isolates belonged to three distinct species including S. intermedius, staphylococcus pseudintermedius, and Staphylococcus delphini, together referred to as the S. intermedius group (SIG). Importantly, it was discovered that all canine isolates investigated belonged to the S. pseudintermedius phylotype and it was concluded that S. pseudintermedius, not S. intermedius, is the common cause of canine pyoderma. Further, it was revealed that S. delphini is more clinically important than was previously thought. The allelic variation of agrD, which encodes the autoinducing peptide (AIP) of the agr quorum sensing system in staphylococci, was determined for all isolates. Four AIP variants were identified, including three which were present in all three species, suggesting that a common quorum sensing capacity has been conserved despite species differentiation in very different niches. Considerable clonal diversity was revealed within the S. pseudintermedius species, including several methicillin-resistant clones which have evolved by recent acquisition of the mecA gene. Using the sequence diversity identified, a simple diagnostic test was developed based on a PCR-RFLP approach to discriminate S. pseudintermedius from S. intermedius and S. delphini. Having established that S. pseudintermedius is the common canine pyoderma pathogen, this study aimed to investugate key host-pathogen interactions involved in colonisation of its canine host. Bioinformatic analysis of the whole genome sequence of a clinical isolate of S. pseudintermedius (strain ED99) revealed 17 genes encoding predicted LPXTG-containing cell wall-anchored (CWA) surface proteins. A diverse collection of S. pseudintermedius isolates and closely related staphylococcal species was screened for the presence of the genes encodng the novel CWA proteins. The majority of genes were widely distributed among the isolates examined, with nine genes being exclusive to S. pseudintermedius and eight being also present in other members of the SIG. In Gram-positive bacteria, a family of CWA proteins called microbial surgace components recognising adhesive matrix molecules (MSCRAMMs)mediates bacterial adherence to extracellular matrix proteins of the host. Three of the 17 predicted novel CWA proteins, designated SpsD, SpsL and SpsO, were selected for further characterisation of their role in host-pathogen interactions and were cloned and expressed on the surface of the surrogate host Lactococcus lactis.…

Subjects/Keywords: 636.089; staphylococcus pseudintermedius; canine pyoderma

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bannoehr, J. (2010). Molecular population and colonisation factor analysis of the Staphylococcus intermedius group. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/5716

Chicago Manual of Style (16^th Edition):

Bannoehr, Jeanette. “Molecular population and colonisation factor analysis of the Staphylococcus intermedius group.” 2010. Doctoral Dissertation, University of Edinburgh. Accessed January 19, 2021. http://hdl.handle.net/1842/5716.

MLA Handbook (7^th Edition):

Bannoehr, Jeanette. “Molecular population and colonisation factor analysis of the Staphylococcus intermedius group.” 2010. Web. 19 Jan 2021.

Vancouver:

Bannoehr J. Molecular population and colonisation factor analysis of the Staphylococcus intermedius group. [Internet] [Doctoral dissertation]. University of Edinburgh; 2010. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1842/5716.

Council of Science Editors:

Bannoehr J. Molecular population and colonisation factor analysis of the Staphylococcus intermedius group. [Doctoral Dissertation]. University of Edinburgh; 2010. Available from: http://hdl.handle.net/1842/5716

University of Helsinki

5. Heikkilä, Kirsi. Kefaleksiinin vaikutus pyodermaa sairastavien koirien iholla ja limakalvoilla esiintyvään S. intermediukseen.

Degree: Department of Clinical Veterinary Sciences; Helsingin yliopisto, Eläinlääketieteellinen tiedekunta, Kliinisen eläinlääketieteen laitos; Helsingfors universitet, Veterinärmedicinska fakulteten, Institutionen för klinisk veterinärmedicin, 1999, University of Helsinki

URL: http://hdl.handle.net/1975/1089

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Koirien yleisin iho-ongelma on pyoderma, jonka pääasiallisin aiheuttajabakteeri on S.intermedius. S.intermediusta on eristetty koirien iholta, karvoista ja limakalvoilta. Limakalvot ovat S.intermediuksen pääasiallisin reservuaaripaikka, josta sen… (more)

Subjects/Keywords: pyoderma; kefaleksiini; S. Intermedius; Sisätautioppi; Internmedicin; Internal Medicine; pyoderma; kefaleksiini; S. Intermedius

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Heikkilä, K. (1999). Kefaleksiinin vaikutus pyodermaa sairastavien koirien iholla ja limakalvoilla esiintyvään S. intermediukseen. (Thesis). University of Helsinki. Retrieved from http://hdl.handle.net/1975/1089

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Heikkilä, Kirsi. “Kefaleksiinin vaikutus pyodermaa sairastavien koirien iholla ja limakalvoilla esiintyvään S. intermediukseen.” 1999. Thesis, University of Helsinki. Accessed January 19, 2021. http://hdl.handle.net/1975/1089.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Heikkilä, Kirsi. “Kefaleksiinin vaikutus pyodermaa sairastavien koirien iholla ja limakalvoilla esiintyvään S. intermediukseen.” 1999. Web. 19 Jan 2021.

Vancouver:

Heikkilä K. Kefaleksiinin vaikutus pyodermaa sairastavien koirien iholla ja limakalvoilla esiintyvään S. intermediukseen. [Internet] [Thesis]. University of Helsinki; 1999. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1975/1089.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Heikkilä K. Kefaleksiinin vaikutus pyodermaa sairastavien koirien iholla ja limakalvoilla esiintyvään S. intermediukseen. [Thesis]. University of Helsinki; 1999. Available from: http://hdl.handle.net/1975/1089

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Larsson Junior, Carlos Eduardo. Estudo comparativo da eficácia da imunoterapia com bacterina e de dois esquemas de pulsoterapia antibiótica no manejo de piodermites superficiais idiopáticas recidivantes caninas.

Degree: Mestrado, Clínica Veterinária, 2008, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/10/10136/tde-30072008-110941/ ;

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As piodermites, superficiais ou profundas, representam uma das dermatopatias caninas mais comuns no cotidiano da clínica dermatológica de cães. Dentre as classificadas como superficiais, destacam-se… (more)

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As piodermites, superficiais ou profundas, representam uma das dermatopatias caninas mais comuns no cotidiano da clínica dermatológica de cães. Dentre as classificadas como superficiais, destacam-se a foliculite bacteriana e a piodermite esfoliativa ou superficial disseminada, que representam a grande maioria dos casos. Em alguns cães, as piodermites superficiais são idiopáticas, apresentam evolução crônica e caráter recidivante. A despeito de criteriosa investigação acerca de sua possível etiologia, por vezes, não se consegue evidenciar a causa para a instalação e recorrência do quadro mórbido. Tais animais apresentam frequentes recidivas, em variáveis períodos de tempo, após o término da terapia antibiótica. Para estes caninos, na bibliografia médico-veterinária há recomendação de emprego das controvertidas imunoterapia ou de antibioticoterapia sob a forma de pulsos. Portanto, objetivou-se na casuística do Serviço de Dermatologia do Hospital Veterinário da USP, determinar as principais espécies bacterianas envolvidas, a susceptibilidade destas frente a diferentes antimicrobianos, bactericidas ou bacteriostáticos, assim como, comparar a eficácia e a segurança de três distintos protocolos terapêuticos no manejo a longo prazo, de piodermites superficiais recidivantes idiopáticas. Utilizaram-se 23 animais, de quaisquer dos sexos, de distintas raças e faixas etárias. A amostragem foi aleatoriamente disposta em três grupos de experimentação (GI, GII, G III), respectivamente submetidos à imunoterapia com bacterina comercial (Estafilin®) e às pulsoterapias de \"finais de semanaöu em \"semanas alternadas\", empregando-se cefalexina \"per os\". O principal patógeno, em 67,6 % da totalidade de isolamentos bacterianos, foi Staphylococcus intermedius. Evidenciou-se (32,4 %), ainda, as espécies S. hyicus, S. schleiferi subespécie coagulans, S. warneri e Micrococcus sp. Segundo os antibiogramas, os fármacos mais efetivos in vitro foram a amoxicilina associada ao clavulanato de potássio, a cefalexina e o ceftiofur. Verificou-se resposta plena em percentis de, respectivamente, 50,0 %, 33,3 % e 28,6 % nos Grupos II, III e I; destarte, ao se agrupar as respostas plena e moderada evidenciaram-se valores relativos de, respectivamente, 83,3 %, 50,0 % e 42,9 %. À luz da estatística (Teste do Qui Quadrado), não se observaram quaisquer diferenças estatisticamente significativas (p > 0,05) entre os percentuais de resposta aos três protocolos empregados. Todos eles mostraram-se seguros, sem acarretar efeitos adversos farmacodérmicos.

Superficial and deep pyodermas are common canine skin disorders in the small animal dermatology practice. Among the superficial form, the bacterial folliculitis and superficial spreading pyoderma represent the great majority of cases. Some dogs are affected by idiopathic, chronic and recurrent type of superficial pyoderma. Despite a rigorous search for possible reasons for its etiology, sometimes it is not possible to determine an underlying cause for the disease recurrence. At variable time periods, these…

Advisors/Committee Members: Larsson, Carlos Eduardo.

Subjects/Keywords: Bacterina estafilocócica; Cães; Dogs; Immunotherapy; Imunoterapia; Piodermite recidivante; Pulse therapy; Pulsoterapia; Recurrent pyoderma; Staphylococcal bacterin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Larsson Junior, C. E. (2008). Estudo comparativo da eficácia da imunoterapia com bacterina e de dois esquemas de pulsoterapia antibiótica no manejo de piodermites superficiais idiopáticas recidivantes caninas. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/10/10136/tde-30072008-110941/ ;

Chicago Manual of Style (16^th Edition):

Larsson Junior, Carlos Eduardo. “Estudo comparativo da eficácia da imunoterapia com bacterina e de dois esquemas de pulsoterapia antibiótica no manejo de piodermites superficiais idiopáticas recidivantes caninas.” 2008. Masters Thesis, University of São Paulo. Accessed January 19, 2021. http://www.teses.usp.br/teses/disponiveis/10/10136/tde-30072008-110941/ ;.

MLA Handbook (7^th Edition):

Larsson Junior, Carlos Eduardo. “Estudo comparativo da eficácia da imunoterapia com bacterina e de dois esquemas de pulsoterapia antibiótica no manejo de piodermites superficiais idiopáticas recidivantes caninas.” 2008. Web. 19 Jan 2021.

Vancouver:

Larsson Junior CE. Estudo comparativo da eficácia da imunoterapia com bacterina e de dois esquemas de pulsoterapia antibiótica no manejo de piodermites superficiais idiopáticas recidivantes caninas. [Internet] [Masters thesis]. University of São Paulo; 2008. [cited 2021 Jan 19]. Available from: http://www.teses.usp.br/teses/disponiveis/10/10136/tde-30072008-110941/ ;.

Council of Science Editors:

Larsson Junior CE. Estudo comparativo da eficácia da imunoterapia com bacterina e de dois esquemas de pulsoterapia antibiótica no manejo de piodermites superficiais idiopáticas recidivantes caninas. [Masters Thesis]. University of São Paulo; 2008. Available from: http://www.teses.usp.br/teses/disponiveis/10/10136/tde-30072008-110941/ ;

7. Ansar Kamran C. Pyoderma in dogs;.

Degree: Animal reproduction, 2006, Karnataka Veterinary, Animal and Fisheries Sciences University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/6947

None

Summary, References and Appendix included

Advisors/Committee Members: Yathiraj S.

Subjects/Keywords: Veterinary Sciences; Animal reproduction; Pyoderma; Dogs

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

C, A. K. (2006). Pyoderma in dogs;. (Thesis). Karnataka Veterinary, Animal and Fisheries Sciences University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/6947

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

C, Ansar Kamran. “Pyoderma in dogs;.” 2006. Thesis, Karnataka Veterinary, Animal and Fisheries Sciences University. Accessed January 19, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/6947.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

C, Ansar Kamran. “Pyoderma in dogs;.” 2006. Web. 19 Jan 2021.

Vancouver:

C AK. Pyoderma in dogs;. [Internet] [Thesis]. Karnataka Veterinary, Animal and Fisheries Sciences University; 2006. [cited 2021 Jan 19]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/6947.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

C AK. Pyoderma in dogs;. [Thesis]. Karnataka Veterinary, Animal and Fisheries Sciences University; 2006. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/6947

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Majauskaitė, Neringa. Bakterinės šunų odos ligos ir jų gydymas.

Degree: Master, Veterinary Medicine, 2014, Lithuanian Academic Libraries Network (LABT)

URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140226_164643-56132 ;

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Bakterinės odos ligos yra vienos dažniausių šunų odos ligų. Darbo tikslas buvo išanalizuoti šunų bakterinių odos ligų patogenezę, klinikinius požymius, diferencinę diagnostiką bei gydymo principus.… (more)

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Bakterinės odos ligos yra vienos dažniausių šunų odos ligų. Darbo tikslas buvo išanalizuoti šunų bakterinių odos ligų patogenezę, klinikinius požymius, diferencinę diagnostiką bei gydymo principus. 2012 – 2013 metais LSMU VA Dr. L. Kriaučeliūno smulkiųjų gyvūnų klinikoje buvo renkami duomenys apie šunų sergamumą bakterinėmis odos ligomis. 301 šuniui buvo diagnozuota odos ligos (201 iš sirgusiųjų sirgo bakterinėmis ligomis, 95 iš jų patelės, 106 – patinai). Klinikinė diagnozė patvirtinta remiantis atliktais mikroskopiniu, mikologiniu ir bakteriologiniu tyrimais. Patinai odos ligomis sirgo dažniau nei patelės (55,48 proc. palyginti su 44,52 proc.) ir dažniausiai sirgo šunys, kurių amžius buvo nuo vienerių iki penkerių metų (43,52 proc.), rečiausiai – vyresni nei penkerių metų šunys (26,24 proc., p<0,001). Dažniausiai odos ligomis šunys serga pavasarį (33,90 proc., p<0,001), rečiausiai rudenį (16,60 proc., p<0,001). Dažniausiai bakterinėmis odos ligomis sirgo čiau čiau (100 proc., p<0,01), amerikiečių Stafordšyro terjerų (90 proc., p<0,01) ir auksaspalvių retriverių (84,62 proc., p<0,01)veislių šunims. Nustatyta, kad dažniausiai bakterinių odos ligų sukėlėjai yra Staphylococcus spp. (37,76 proc.) bakterijos. Labai tikėtina, kad tai buvo Staphylococcus pseudointermedius, Staphylococcus delphini ir Staphylococcus epidermidis, tačiau jos fenotipiškai neidentifikuotos. Taip pat dažnas bakterinių ligų sukėlėjas yra Staphylococcus aureus (31,47 proc.). Nustatytas bakterijų jautrumas... [toliau žr. visą tekstą]

Bacterial skin diseases are one of the most common diseases of dogs. Work aim – to analyse the pathogenesis of the bacterial skin diseases of dogs, their clinical symptoms, differential diagnostics and treatment principles. In 2012–2013 data on the dog morbidity (bacterial skin diseases) has been collected at Dr. L. Kriaučeliūnas Small Animal Clinic of Veterinary Academy of Lithuanian University of Health Sciences. Skin diseases have been diagnosed to 301 dogs (201 of them were ill with the bacterial diseases, 95 of them were females, and 106 – males). Clinical diagnosis has been approved according to the microscopic, mycological and bacteriological tests. Male dogs were ill with the skin diseases more often compared to the females (55.48% vs. 44.52%), and the dogs from one to five years old have been ill the most often (43.52%), rariest – dogs older than five years (26.24, p<0.001). Dogs are ill with the skin diseases in spring (33.90%, p<0.001) the most often, rarest – in autumn (16.60%, p<0.001). Chow Chow (100%, p<0.01), American Staffordshire terriers (90%, p<0.01) and Golden Retrievers (84.62%, p<0.01) were ill with the baterial skin diseases the most often. It has been determined that the most common factor of the bacterial skin diseases is Staphylococcus spp. (37.76%) bacteria. It is presumptive that they were Staphylococcus pseudointermedius, Staphylococcus delphini and Staphylococcus epidermidis, however, they have not been identified phenotypically. In addition,... [to full text]

Advisors/Committee Members: Jokimas, Juozas (Master’s degree committee chair), Laurinavičiūtė, Vilija (Master’s degree session secretary), Aniulienė, Albina (Master’s degree committee member), Paunksnienė, Marija (Master’s degree committee member), Bakutis, Bronius (Master’s degree committee member), Gedgaudas, Edvardas (Master’s degree committee member), Šiukščius, Arūnas (Master’s degree committee member), Stakauskas, Rimantas (Master’s degree committee member), Grigonis, Aidas (Master’s thesis supervisor).

Subjects/Keywords: Šuo; Piodermija; Bakterijų jautrumas antimikrobinėms medžiagoms; Dog; Pyoderma; Bacteria sensitivity to the antimicrobial drugs

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Majauskaitė, Neringa. (2014). Bakterinės šunų odos ligos ir jų gydymas. (Masters Thesis). Lithuanian Academic Libraries Network (LABT). Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140226_164643-56132 ;

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Chicago Manual of Style (16^th Edition):

Majauskaitė, Neringa. “Bakterinės šunų odos ligos ir jų gydymas.” 2014. Masters Thesis, Lithuanian Academic Libraries Network (LABT). Accessed January 19, 2021. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140226_164643-56132 ;.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

MLA Handbook (7^th Edition):

Majauskaitė, Neringa. “Bakterinės šunų odos ligos ir jų gydymas.” 2014. Web. 19 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

Majauskaitė, Neringa. Bakterinės šunų odos ligos ir jų gydymas. [Internet] [Masters thesis]. Lithuanian Academic Libraries Network (LABT); 2014. [cited 2021 Jan 19]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140226_164643-56132 ;.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Council of Science Editors:

Majauskaitė, Neringa. Bakterinės šunų odos ligos ir jų gydymas. [Masters Thesis]. Lithuanian Academic Libraries Network (LABT); 2014. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140226_164643-56132 ;

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

University of Cape Town

9. Lawrence, Pat. Pyoderma gangrenosum : the Groote Schuur Hospital experience, 1970-1990.

Degree: Image, Division of Dermatology, 1991, University of Cape Town

URL: http://hdl.handle.net/11427/25568

Subjects/Keywords: Pyoderma - Groote Schuur Hospital, 1970-1990; Pyoderma - diagnosis - Groote Schuur Hospital, 1970-1990; Pyoderma - drug therapy - Groote Schuur Hospital, 1970-1990

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lawrence, P. (1991). Pyoderma gangrenosum : the Groote Schuur Hospital experience, 1970-1990. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/25568

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lawrence, Pat. “Pyoderma gangrenosum : the Groote Schuur Hospital experience, 1970-1990.” 1991. Thesis, University of Cape Town. Accessed January 19, 2021. http://hdl.handle.net/11427/25568.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lawrence, Pat. “Pyoderma gangrenosum : the Groote Schuur Hospital experience, 1970-1990.” 1991. Web. 19 Jan 2021.

Vancouver:

Lawrence P. Pyoderma gangrenosum : the Groote Schuur Hospital experience, 1970-1990. [Internet] [Thesis]. University of Cape Town; 1991. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/11427/25568.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lawrence P. Pyoderma gangrenosum : the Groote Schuur Hospital experience, 1970-1990. [Thesis]. University of Cape Town; 1991. Available from: http://hdl.handle.net/11427/25568

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Technical University of Lisbon

10. Mascarenhas, Diana Marisa Cardoso. Utilização de extracto de Staphylococcus pseudintermedius em testes alergológicos cutâneos no cão : um estudo preliminar.

Degree: 2014, Technical University of Lisbon

URL: http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/7236

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Dissertação de Mestrado Integrado em Medicina Veterinária

Nos cães com dermatite atópica, as infeções cutâneas recorrentes causadas pelo Staphylococcus pseudintermedius são extremamente comuns. Estudos prévios… (more)

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Dissertação de Mestrado Integrado em Medicina Veterinária

Nos cães com dermatite atópica, as infeções cutâneas recorrentes causadas pelo Staphylococcus pseudintermedius são extremamente comuns. Estudos prévios demonstraram que cães atópicos com piodermite recorrente têm títulos mais elevados de imunoglobulina E anti-Staphylococcus no soro. Os principais objetivos deste estudo foram definir qual a concentração ideal de extrato de alergénios de S. pseudintermedius a utilizar nos testes intradérmicos de cães atópicos e posteriormente determinar a frequência de hipersensibilidade cutânea ao S. pseudintermedius em cães atópicos com história de infeção cutânea recorrente. Para isso, realizaram-se testes intradérmicos, onde se testaram diferentes concentrações de extrato de um S. pseudintermedius resistente à meticilina (MRSP), estirpe 5819/10. Esta estirpe foi isolada de um cão com piodermite profunda e apresentava os seguintes genes de virulência: luk-I, se-int, siet, speta, ebpS e spsL. As concentrações utilizadas foram 2 μg/ml, 20 μg/ml e 200 μg/ml, assim como um controlo positivo (fosfato de histamina 0.001%) e um controlo negativo (PBS 0.9%). Foram incluídos neste estudo, vinte e três cães saudáveis e vinte e quatro cães atópicos com infeção cutânea recorrente por S. pseudintermedius, diagnosticados por citologia cutânea e/ou cultura bacteriana. Dos 23 cães saudáveis presentes neste estudo, 14 (61%) apresentaram reação positiva na concentração de 200 μg/ml. Assim sendo, é bastante provável que a concentração de 200 μg/ml seja irritante e por isso resulte em reações falso-positivas. A concentração de 20 μg/ml foi a concentração mais indicada para ser usada no diagnóstico de hipersensibilidade ao S. pseudintermedius em cães atópicos. Posteriormente, foram realizados testes intradérmicos em 24 canídeos atópicos com piodermite e/ou otite bacteriana recorrente com a concentração de 20 μg/ml; quatro destes animais apresentaram reações positivas nesta concentração, o que parecer indicar a existência de reações de hipersensibilidade imediata a componentes do S. pseudintermedius. No entanto, limitações que envolviam o extrato impediram a obtenção de resultados reprodutíveis e uniformes. Acreditamos que a imunoterapia específica para esta bactéria pode ser benéfica para o tratamento destes pacientes, o que torna fundamental o diagnóstico de hipersensibilidade ao S. pseudintermedius. Nesse sentido, deverão ser realizados mais estudos, de modo a obter um extrato fidedigno que permite alcançar consistência e reprodutibilidade em ambiente clínico e assim melhorar a qualidade dos resultados obtidos nos testes intradérmicos.

ABSTRACT - THE USE OF STAPHYLOCOCCUS PSEUDINTERMEDIUS EXTRACT IN SKIN ALLERGY TESTS ON THE DOG – A PRELIMINARY STUDY - In dogs with atopic dermatitis, recurrent skin infections caused by Staphylococcus pseudintermedius are extremely common. Previous studies demonstrated that atopic dogs with recurrent pyoderma have higher titters of anti-Staphylococcus immunoglobulin E. The main objectives of this study…

Advisors/Committee Members: Lourenço, Ana Mafalda Gonçalves Xavier Félix, Pomba, Maria Constança Matias Ferreira.

Subjects/Keywords: S. pseudintermedius; Extrato de alergénios; Infeção cutânea recorrente; Dermatite atópica canina; Allergens extracts; Recurrent pyoderma; Canine atopic dermatitis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mascarenhas, D. M. C. (2014). Utilização de extracto de Staphylococcus pseudintermedius em testes alergológicos cutâneos no cão : um estudo preliminar. (Thesis). Technical University of Lisbon. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/7236

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mascarenhas, Diana Marisa Cardoso. “Utilização de extracto de Staphylococcus pseudintermedius em testes alergológicos cutâneos no cão : um estudo preliminar.” 2014. Thesis, Technical University of Lisbon. Accessed January 19, 2021. http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/7236.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mascarenhas, Diana Marisa Cardoso. “Utilização de extracto de Staphylococcus pseudintermedius em testes alergológicos cutâneos no cão : um estudo preliminar.” 2014. Web. 19 Jan 2021.

Vancouver:

Mascarenhas DMC. Utilização de extracto de Staphylococcus pseudintermedius em testes alergológicos cutâneos no cão : um estudo preliminar. [Internet] [Thesis]. Technical University of Lisbon; 2014. [cited 2021 Jan 19]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/7236.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mascarenhas DMC. Utilização de extracto de Staphylococcus pseudintermedius em testes alergológicos cutâneos no cão : um estudo preliminar. [Thesis]. Technical University of Lisbon; 2014. Available from: http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/7236

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Technical University of Lisbon

11. Cardoso, Joana Raquel Duarte. A polihexanida no controlo de infeções bacterianas e por Malassezia : estudo clínico preliminar no cão.

Degree: 2017, Technical University of Lisbon

URL: https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13438

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Dissertação de Mestrado Integrado em Medicina Veterinária

As piodermites são consideradas as doenças de pele mais frequentes no cão e a dermatite por Malassezia é… (more)

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Dissertação de Mestrado Integrado em Medicina Veterinária

As piodermites são consideradas as doenças de pele mais frequentes no cão e a dermatite por Malassezia é cada vez mais relevante. O problema das resistências aos antimicrobianos e, em especial, dos estafilococos multirresistentes, tanto em Saúde Animal como em Saúde Humana, torna as opções terapêuticas sistémicas limitadas, imperando uma necessidade de gestão e preservação dos antimicrobianos disponíveis, de pesquisa de alternativas e de proteção da saúde pública. A terapêutica tópica é, assim, cada vez mais privilegiada, sendo a clorexidina o antisséptico mais usado na Dermatologia Veterinária. Já em Medicina Humana a polihexanida é o antisséptico de primeira linha no tratamento de feridas infetadas. Assim, este ensaio clínico randomizado e controlado pretendeu investigar a eficácia de uma solução de polihexanida a 0,1% (Prontosan®, B.Braun Medical, Lda, Portugal) no tratamento de infeções de pele bacterianas e/ou por Malassezia no cão, aplicada uma vez por dia, num máximo de seis semanas e, adicionalmente, comparar essa eficácia à de uma solução de digluconato de clorexidina a 2%. A resposta ao tratamento foi definida pela progressão de um score clínico e citológico atribuídos segundo escalas de, respetivamente, três e quatro pontos, sendo também registada a opinião dos donos. Com a utilização da polihexanida foi observada uma melhoria clínica em 75% (6/8) dos doentes com pelo menos uma consulta de seguimento vs. 60% (6/10) no grupo da clorexidina. Houve uma melhoria clínica de pelo menos 50% associada a cura citológica em metade dos doentes tratados com polihexanida, que alcançaram a cura clínica entre os 14 e 31 dias vs. 21 dias para o único doente que atingiu cura clínica com a clorexidina. A cura citológica foi mais frequente que a cura clínica em ambos os grupos e ocorreu entre os dias 7 e 24 para a polihexanida vs. 8 e 22 para a clorexidina. Os resultados sugerem que a polihexanida é eficaz no tratamento de algumas piodermites, com ou sem sobrecrescimento de Malassezia, sendo muito bem tolerada. A sua eficácia parece ser pelo menos semelhante à da clorexidina e, além disso, não se observaram reações adversas. Isto pode indicar uma vantagem sobre a clorexidina, que, neste estudo, esteve implicada numa dermatite de contacto. A investigação relativa à polihexanida nesta área pode e deve continuar. Considerando os seus atributos de promoção da cicatrização e os resultados positivos deste estudo seria importante avaliar a sua utilização em piodermites profundas. Há, todavia, uma grande falta de conhecimento sobre as consequências da exposição prolongada e subterapêutica dos microrganismos a estes antissépticos.

ABSTRACT - POLYHEXANIDE IN THE TREATMENT OF PYODERMA AND MALASSEZIA DERMATITIS: PRELIMINARY CLINICAL TRIAL IN THE DOG - Pyoderma is considered the most frequent skin disease in the dog and Malassezia dermatitis is increasingly relevant. The problem of antimicrobial resistance and specially the multirresistant staphylococci in both Animal and…

Advisors/Committee Members: Lourenço, Ana Mafalda Gonçalves Xavier Félix.

Subjects/Keywords: polihexanida; infeções cutâneas; piodermite; Malassezia; tratamento tópico; ensaio clínico; polyhexanide; skin infections; pyoderma; topical treatment; clinical trial

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cardoso, J. R. D. (2017). A polihexanida no controlo de infeções bacterianas e por Malassezia : estudo clínico preliminar no cão. (Thesis). Technical University of Lisbon. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13438

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cardoso, Joana Raquel Duarte. “A polihexanida no controlo de infeções bacterianas e por Malassezia : estudo clínico preliminar no cão.” 2017. Thesis, Technical University of Lisbon. Accessed January 19, 2021. https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13438.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cardoso, Joana Raquel Duarte. “A polihexanida no controlo de infeções bacterianas e por Malassezia : estudo clínico preliminar no cão.” 2017. Web. 19 Jan 2021.

Vancouver:

Cardoso JRD. A polihexanida no controlo de infeções bacterianas e por Malassezia : estudo clínico preliminar no cão. [Internet] [Thesis]. Technical University of Lisbon; 2017. [cited 2021 Jan 19]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13438.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cardoso JRD. A polihexanida no controlo de infeções bacterianas e por Malassezia : estudo clínico preliminar no cão. [Thesis]. Technical University of Lisbon; 2017. Available from: https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13438

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. Devesa, Joana Sofia Pinto. Resistência a antibióticos em staphylococcus pseudintermedius de isolados cutâneos de cães com piodermite superficial.

Degree: 2015, Repositório Científico Lusófona

URL: https://www.rcaap.pt/detail.jsp?id=oai:recil.grupolusofona.pt:10437/6798

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Staphylococcus pseudintermedius é uma bactéria comensal da pele e mucosa do cão, sendo o principal agente etiológico de piodermite bacteriana superficial e uma das principais… (more)

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Staphylococcus pseudintermedius é uma bactéria comensal da pele e mucosa do cão, sendo o principal agente etiológico de piodermite bacteriana superficial e uma das principais causas para prescrição antibiótica em clínica de pequenos animais. O presente estudo teve como objetivo a determinação do perfil de resistência aos antibióticos recomendados pelas linhas de orientação da International Society for Companion Animal Infectious Disease (ISCAID), num grupo de isolados de S. pseudintermedius suscetíveis e resistentes à meticilina, provenientes de cães com piodermite superficial. Avaliou-se, igualmente, a incidência de multirresistência e a aplicabilidade das linhas de orientação da ISCAID neste grupo de isolados. Este constitui um estudo prospetivo, tendo sido utilizados 55 isolados de S. pseudintermedius, testados para a suscetibilidade à oxacilina pela técnica de Kirby-Bauer e, posteriormente, divididos em dois grupos: S. pseudintermedius resistente à meticilina (MRSP, 25/55, 45%) e S. pseudintermedius suscetível à meticilina (MSSP, 30/55, 55%). No grupo MRSP, foi observado 96% de resistência a ambas clindamicina e eritromicina; 92% à amoxicilina-ácido clavulânico, trimetoprim-sulfametoxazol e pradofloxacina; 88% à cefalotina, enrofloxacina e gentamicina; 80% à tetraciclina; 40% à minociclina; 12% ao cloranfenicol e rifampicina; e 8% à amicacina. No grupo MSSP, verificou-se 70% de resistência à tetraciclina; 67% à minociclina; 47% à eritromicina; 43% à clindamicina; 27% ao trimetoprim-sulfametoxazol; 23% ao cloranfenicol; 10% à gentamicina; 7% a ambas enrofloxacina e pradofloxacina; 3% à rifampicina e amicacina; e 0% de resistência à amoxicilina-ácido clavulânico e cefalotina. Foi possível, ainda, verificar que 66% dos isolados demonstraram-se multirresistentes, sendo que 67% eram MRSP e 33% MSSP; 33% demonstraram-se não multirresistentes, dos quais 95% eram MSSP e apenas 5% MRSP. Verifica-se, assim, a existência de níveis elevados de resistência a antibióticos de primeira escolha, muitas vezes utilizados de forma empírica e sem realização de antibiograma prévio. Este facto limita a sua utilização por parte do Médico Veterinário em isolados MRSP, apesar de no grupo MSSP ainda se detetar evidentes suscetibilidades. O número de isolados multirresistentes é, também, alarmante, diminuindo o número de alternativas antibióticas disponíveis em casos cujas opções antibióticas são limitadas, o que ocorre frequentemente em clínica de referência.

Staphylococcus pseudintermedius is part of the normal microbiota of canine skin and mucosa. It is also the main etiological pathogen of canine superficial pyoderma, in addition to being a major cause for antimicrobial prescription in small animal practice. This study aimed to determine the resistance of the antibiotics recommended by the guidelines of the International Society for Companion Animal Infectious Disease (ISCAID) guidelines, in a group of S. pseudintermedius isolates susceptible and resistant to methicillin, from dogs with superficial pyoderma. The incidence of…

Advisors/Committee Members: Alves, Margarida, orient..

Subjects/Keywords: MESTRADO INTEGRADO EM MEDICINA VETERINÁRIA; VETERINÁRIA; CÃES; PIODERMITE; BACTERIOLOGIA VETERINÁRIA; ANTIBIÓTICOS; RESISTÊNCIA AOS ANTIBIÓTICOS; PENICILINA; DOGS; PYODERMA; VETERINARY BACTERIOLOGY; ANTIBIOTICS; ANTIMICROBIAL RESISTANCE; PENICILLIN; MEDICINA VETERINÁRIA; VETERINARY MEDICINE

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Devesa, J. S. P. (2015). Resistência a antibióticos em staphylococcus pseudintermedius de isolados cutâneos de cães com piodermite superficial. (Thesis). Repositório Científico Lusófona. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:recil.grupolusofona.pt:10437/6798

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Devesa, Joana Sofia Pinto. “Resistência a antibióticos em staphylococcus pseudintermedius de isolados cutâneos de cães com piodermite superficial.” 2015. Thesis, Repositório Científico Lusófona. Accessed January 19, 2021. https://www.rcaap.pt/detail.jsp?id=oai:recil.grupolusofona.pt:10437/6798.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Devesa, Joana Sofia Pinto. “Resistência a antibióticos em staphylococcus pseudintermedius de isolados cutâneos de cães com piodermite superficial.” 2015. Web. 19 Jan 2021.

Vancouver:

Devesa JSP. Resistência a antibióticos em staphylococcus pseudintermedius de isolados cutâneos de cães com piodermite superficial. [Internet] [Thesis]. Repositório Científico Lusófona; 2015. [cited 2021 Jan 19]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:recil.grupolusofona.pt:10437/6798.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Devesa JSP. Resistência a antibióticos em staphylococcus pseudintermedius de isolados cutâneos de cães com piodermite superficial. [Thesis]. Repositório Científico Lusófona; 2015. Available from: https://www.rcaap.pt/detail.jsp?id=oai:recil.grupolusofona.pt:10437/6798

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. Pereira, Vera Guilhermina Alves. Estudo retrospectivo da resistência bacteriana na dermatite atópica canina.

Degree: 2013, Repositório Científico Lusófona

URL: https://www.rcaap.pt/detail.jsp?id=oai:recil.grupolusofona.pt:10437/5351

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A piodermite é uma das patologias mais comuns na prática clínica sendo frequentemente tratada com recurso à antibioterapia. O objetivo desta dissertação é caracterizar a… (more)

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A piodermite é uma das patologias mais comuns na prática clínica sendo frequentemente tratada com recurso à antibioterapia. O objetivo desta dissertação é caracterizar a presença de estafilococos multirresistentes num grupo de canídeos com piodermite causada por Staphylococcus spp. Este é um estudo retrospectivo e foi elaborado com 36 cães com dermatite atópica e piodermite bacteriana observados na consulta de referência de dermatologia. O grupo de estudo foi dividido em pacientes com piodermite causada por estafilococos não multirresistentes e por estafilococos multirresistentes. A incidência de estirpes resistentes a uma ou duas classes de antibióticos foi de 47% e de multirresistentes foi 53%, o que indica uma maior frequência de estafilococos multirresistentes. O grupo dos estafilococos multirresistentes distingue-se do grupo dos não multirresistentes pela presença uma incidência superior de resistência à amoxicilina/ácido clavulânico, às cefalosporinas, aos aminoglicosídeos, à enrofloxacina, à eritromicina, ao sulfametoxazol/ trimetoprim e à doxicilina. Verificaram-se altos níveis de resistência à lincomicina em ambos os grupos. Foram avaliados fatores de risco que poderiam estar associados com a presença de estafilococos multirresistentes. Não se verificou associação entre a multirresistência e os seguintes fatores: idade, género, estado fértil, raça, duração e tipo da piodermite, antibioterapia prévia e área do profissional do proprietário.

Pyoderma, is one of the most common diseases in clinical practice is often treated with the use of antibiotics. The aim of this work is to characterize the presence of multidrug-resistant staphylococci in a group of dogs with pyoderma caused by Staphylococcus spp. This is a retrospective study and was designed with 36 dogs with atopic dermatitis and bacterial pyoderma that were observed in dermatology’s referral consultation. The study group was divided in patients with pyoderma caused by no multiresistant staphylococci and patients with pyoderma caused by multiresistant strains of staphylococci. The incidence of resistant strains to one or two classes of antibiotics and multiresistant was 47% and 53% respectively, which indicates a high frequency of multiresistant staphylococci. The group of multiresistant staphylococci is distinct from the group of non-multiresistant staphylococci: there was a higher incidence of resistance to amoxicillin / clavulanic acid, cephalosporins, aminoglycosides, enrofloxacin, erythromycin, trimethoprim / sulfamethoxazole and doxycycline in the multiresistant group. We observed high levels of resistance to lincomycin in both groups. Several risk factors that could be associated with the presence of multiresistant Staphylococcus spp. in dog’s pyoderma were studied. There was no association between multidrug resistance and the following factors: age, gender, reproductive status, race, duration and type of pyoderma, previous treatment with antibiotics and owner's professional area.

Orientação: Alexandra Sanfins ; co-orientadora: Ana Oliveira

Advisors/Committee Members: Sanfins, Alexandra, orient..

Subjects/Keywords: VETERINÁRIA; CANÍDEOS; PIODERMITE; CANIDS; PYODERMA; MESTRADO INTEGRADO EM MEDICINA VETERINÁRIA; CÃES; DOGS; DERMATITE ATÓPICA; ATOPIC DERMATITIS; RESISTÊNCIA AOS ANTIBIÓTICOS; ANTIMICROBIAL RESISTANCE; MEDICINA VETERINÁRIA; VETERINARY MEDICINE

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pereira, V. G. A. (2013). Estudo retrospectivo da resistência bacteriana na dermatite atópica canina. (Thesis). Repositório Científico Lusófona. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:recil.grupolusofona.pt:10437/5351

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pereira, Vera Guilhermina Alves. “Estudo retrospectivo da resistência bacteriana na dermatite atópica canina.” 2013. Thesis, Repositório Científico Lusófona. Accessed January 19, 2021. https://www.rcaap.pt/detail.jsp?id=oai:recil.grupolusofona.pt:10437/5351.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pereira, Vera Guilhermina Alves. “Estudo retrospectivo da resistência bacteriana na dermatite atópica canina.” 2013. Web. 19 Jan 2021.

Vancouver:

Pereira VGA. Estudo retrospectivo da resistência bacteriana na dermatite atópica canina. [Internet] [Thesis]. Repositório Científico Lusófona; 2013. [cited 2021 Jan 19]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:recil.grupolusofona.pt:10437/5351.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pereira VGA. Estudo retrospectivo da resistência bacteriana na dermatite atópica canina. [Thesis]. Repositório Científico Lusófona; 2013. Available from: https://www.rcaap.pt/detail.jsp?id=oai:recil.grupolusofona.pt:10437/5351

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. Mercer, Heather Milliken. The Distribution of Single Nucleotide Polymorphisms in Pyoderma Gangrenosum: Biomarker Discovery.

Degree: MS, College of Arts and Sciences / Department of Biological Sciences, 2013, Kent State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=kent1383769612

► Pyoderma gangrenosum (PG) is a rare, inflammatory disease marked by reactive, neutrophilic dermatosis. While PG is non-infectious, it is painful, only diagnosed by exclusion of… (more)

▼ Pyoderma gangrenosum (PG) is a rare, inflammatory disease marked by reactive, neutrophilic dermatosis. While PG is non-infectious, it is painful, only diagnosed by exclusion of other disorders (Bhat, 2012), and challenging to treat. Thus, there exists a need for discovery of biomarkers that can aid in faster and more reliable diagnosis. Whole-genome genotyping platforms- such as Affymetrix SNP 6.0 chip - offer rapid and comprehensive ways to survey patients' genomes to identify shared genetic polymorphisms as part of the biomarker discovery.In this work we test the hypothesis that PG is caused by genetic variants within the genome that (1) inhibit neutrophil clearance and immune/inflammatory pathways and (2) that a combination of Single Nucleotide Polymorphisms (SNPs) across multiple loci in this pathway may contribute to this dysfunction. We examined a list of 64,997 SNPs found in 9,831 genes that were shared across six PG patients. These genes were examined to determine whether an over-enrichment of immune- and/or inflammation and/or apoptosis variants exists across patients using Gene Ontology tools. Gene Ontology tools provided insight into the functional classifications of these genes and possible connections to PG etiology. The genes found in common between the PG data set and those known to be active in apoptotic and immunity/inflammatory pathways were further analyzed for the potential effects of genetic variation. Those genetic variants located within exons and 5' and 3' untranslated regions in addition to those that cause missense or nonsense were viewed as the most likely to be related to PG as mutations in those regions are most likely to alter protein products. In addition to the aforementioned genetic regions, those SNPS located in non-coding genic regions (potentially regulatory) as well as those from the inter-genic regions were analyzed. The latter category, while currently lacking known functional annotations, may provide insight into the genome function as putative regulatory regions and/or non-coding RNA as suggested by recent endeavors such as the ENCODE project. Analyses resulted in the discovery of an over-enrichment of SNPs within genes functioning within both apoptotic and immune/inflammatory pathways within the PG Data Set in addition to SNPS located in genes that may be integral to the development of PG. Advisors/Committee Members: Piontkivska, Helen (Advisor).

Subjects/Keywords: Biology; Bioinformatics; Genetics; Pyoderma Gangrenosum; SNP; Single Nucleotide Polymorphism; Genetic Variant; Biomarkers

…Chapter 1: Pyoderma Gangrenosum, Inflammation, and Apoptosis Table 1: List of diseases which are… …of Classic, Ulcerative Pyoderma Gangrenosum (PG). Diagnosis requires both major… …genes ��p. 101 xii LIST OF ABBREVIATIONS PG ��.Pyoderma Gangrenosum SNPs ��Single Nucleotide… …pyoderma gangrenosum, and acne IBD ��Irritable Bowel Syndrome RA ��Rheumatoid Arthritis UC… …POLYMORPHISMS IN PYODERMA GANGRENOSUM: BIOMARKER DISCOVERY I. To be completed by the student: I…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mercer, H. M. (2013). The Distribution of Single Nucleotide Polymorphisms in Pyoderma Gangrenosum: Biomarker Discovery. (Masters Thesis). Kent State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=kent1383769612

Chicago Manual of Style (16^th Edition):

Mercer, Heather Milliken. “The Distribution of Single Nucleotide Polymorphisms in Pyoderma Gangrenosum: Biomarker Discovery.” 2013. Masters Thesis, Kent State University. Accessed January 19, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=kent1383769612.

MLA Handbook (7^th Edition):

Mercer, Heather Milliken. “The Distribution of Single Nucleotide Polymorphisms in Pyoderma Gangrenosum: Biomarker Discovery.” 2013. Web. 19 Jan 2021.

Vancouver:

Mercer HM. The Distribution of Single Nucleotide Polymorphisms in Pyoderma Gangrenosum: Biomarker Discovery. [Internet] [Masters thesis]. Kent State University; 2013. [cited 2021 Jan 19]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=kent1383769612.

Council of Science Editors:

Mercer HM. The Distribution of Single Nucleotide Polymorphisms in Pyoderma Gangrenosum: Biomarker Discovery. [Masters Thesis]. Kent State University; 2013. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=kent1383769612

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