subject:(PH responsive)

University of Manitoba

1. Sedigheh, Nazaripour. pH Responsive Polymer Brushes grafted from the surface of Intravaginal Ring for on-demand drug delivery.

Degree: Chemistry, 2016, University of Manitoba

URL: http://hdl.handle.net/1993/31828

► A new pH sensitive polyurethane intravaginal ring reservoir (PU Res IVR) drug delivery system was developed using a novel and versatile method. A combination of… (more)

Subjects/Keywords: pH Responsive; Polymer Brushes; Intravagianl Ring; Stimuli-Responsive

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APA (6^th Edition):

Sedigheh, N. (2016). pH Responsive Polymer Brushes grafted from the surface of Intravaginal Ring for on-demand drug delivery. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/31828

Chicago Manual of Style (16^th Edition):

Sedigheh, Nazaripour. “pH Responsive Polymer Brushes grafted from the surface of Intravaginal Ring for on-demand drug delivery.” 2016. Masters Thesis, University of Manitoba. Accessed January 16, 2021. http://hdl.handle.net/1993/31828.

MLA Handbook (7^th Edition):

Sedigheh, Nazaripour. “pH Responsive Polymer Brushes grafted from the surface of Intravaginal Ring for on-demand drug delivery.” 2016. Web. 16 Jan 2021.

Vancouver:

Sedigheh N. pH Responsive Polymer Brushes grafted from the surface of Intravaginal Ring for on-demand drug delivery. [Internet] [Masters thesis]. University of Manitoba; 2016. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/1993/31828.

Council of Science Editors:

Sedigheh N. pH Responsive Polymer Brushes grafted from the surface of Intravaginal Ring for on-demand drug delivery. [Masters Thesis]. University of Manitoba; 2016. Available from: http://hdl.handle.net/1993/31828

2. Thaiboonrod, Sineenat. Injectable microgel systems: towards an injectable gel for heart tissue repair.

Degree: 2014, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:230574

► This thesis presents an investigation of cationic microgels based on poly(N-vinylformamide-co-glycidyl methacrylate) (PNVF-GMA) and poly(N-vinylformamide-co-2-(N-vinylformamido) ethyl ether) (PNVF-NVEE). They arestudied in the context of future… (more)

▼ This thesis presents an investigation of cationic microgels based on poly(N-vinylformamide-co-glycidyl methacrylate) (PNVF-GMA) and poly(N-vinylformamide-co-2-(N-vinylformamido) ethyl ether) (PNVF-NVEE). They arestudied in the context of future heteroaggregated doubly crosslinked (DX) microgelsfor damaged heart tissue repair. The microgel particles were synthesised fromPNVF-GMA, which is also a water swellable microgel. The PNVF-GMA particleshad a core-shell structure in which PNVF provides the core and PGMA creates thecross-linked shell. The morphology of particles is that of a “cane-ball” like shape.There are interconnected ridges, and this unusual morphology can be controlled bythe weight fraction of GMA used during preparation. The hydrolysed PNVF-GMA(H-PNVF-GMA) particles were both positively and negatively charged. Moreover,charge patch aggregation occurred at low ionic strength. However, these microgelswere colloidally unstable after water rinsing due to shell fragmentation.PNVF microgel particles containing (N-Vinylformamido) ethyl ether (NVEE) as acrosslinking agent were also studied to avoid the fragmentation of the particles. Thismicrogel was hydrolysed in alkali conditions to provide poly(vinylamine-co-bis(ethyl vinylamine) ether) (PVAM-BEVAME), which contains primary aminegroups. It is proposed from the data presented that the content of hydrolysis was veryhigh and the particles were stable after hydrolysis owing to the stability of etherlinkage in NVEE. These microgels were able to swell upon decreasing pH. ThePVAM-BEVAME microgel with 9 mol% of BEVAME was then used to formdoubly crosslinked (DX) microgel. To form the inter-particles crosslinking, the vinylgroups were included by functionalisation using glycidyl methacrylate (GMA)monomer. The vinyl groups of neighbouring particles were linked together via freeradical reaction. The DX microgel formed under physiological temperature andshowed extensive porosity. These DX microgels had good mechanical propertiesconfirmed by high storage modulus (G’). Moreover, the precursor gels wereinjectable which is favourable for future biomaterial applications. The study providesa new family of cationic microgel that may be suitable for a future heteroaggregatedDX microgel for heart tissue repair.

Subjects/Keywords: microgel; pH-responsive; injectable gel; cationic microgel

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APA (6^th Edition):

Thaiboonrod, S. (2014). Injectable microgel systems: towards an injectable gel for heart tissue repair. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:230574

Chicago Manual of Style (16^th Edition):

Thaiboonrod, Sineenat. “Injectable microgel systems: towards an injectable gel for heart tissue repair.” 2014. Doctoral Dissertation, University of Manchester. Accessed January 16, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:230574.

MLA Handbook (7^th Edition):

Thaiboonrod, Sineenat. “Injectable microgel systems: towards an injectable gel for heart tissue repair.” 2014. Web. 16 Jan 2021.

Vancouver:

Thaiboonrod S. Injectable microgel systems: towards an injectable gel for heart tissue repair. [Internet] [Doctoral dissertation]. University of Manchester; 2014. [cited 2021 Jan 16]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:230574.

Council of Science Editors:

Thaiboonrod S. Injectable microgel systems: towards an injectable gel for heart tissue repair. [Doctoral Dissertation]. University of Manchester; 2014. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:230574

Vanderbilt University

3. Werfel, Thomas Anthony. Combinatorial Library of Ternary Polyplexes Enables Identification of Improved siRNA Nanocarriers for Rapid In Vivo Translation.

Degree: MS, Biomedical Engineering, 2015, Vanderbilt University

URL: http://hdl.handle.net/1803/10946

► A combinatorial library of ternary polyplexes was herein investigated to optimize formulations for siRNA delivery. The compositions tested build from our previous finding that balancing… (more)

Subjects/Keywords: Polyplexes; pH-responsive; intravenous delivery; siRNA

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APA (6^th Edition):

Werfel, T. A. (2015). Combinatorial Library of Ternary Polyplexes Enables Identification of Improved siRNA Nanocarriers for Rapid In Vivo Translation. (Thesis). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/10946

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Werfel, Thomas Anthony. “Combinatorial Library of Ternary Polyplexes Enables Identification of Improved siRNA Nanocarriers for Rapid In Vivo Translation.” 2015. Thesis, Vanderbilt University. Accessed January 16, 2021. http://hdl.handle.net/1803/10946.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Werfel, Thomas Anthony. “Combinatorial Library of Ternary Polyplexes Enables Identification of Improved siRNA Nanocarriers for Rapid In Vivo Translation.” 2015. Web. 16 Jan 2021.

Vancouver:

Werfel TA. Combinatorial Library of Ternary Polyplexes Enables Identification of Improved siRNA Nanocarriers for Rapid In Vivo Translation. [Internet] [Thesis]. Vanderbilt University; 2015. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/1803/10946.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Werfel TA. Combinatorial Library of Ternary Polyplexes Enables Identification of Improved siRNA Nanocarriers for Rapid In Vivo Translation. [Thesis]. Vanderbilt University; 2015. Available from: http://hdl.handle.net/1803/10946

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cambridge

4. Chen, Alexander. The engineering and development of pH-responsive biopolymers for drug delivery applications.

Degree: PhD, 2019, University of Cambridge

URL: https://doi.org/10.17863/CAM.45789 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.792983

► This dissertation describes experimental studies to understand the structure of biocompatible pH responsive polymers and their interaction with the biological system in order to design… (more)

▼ This dissertation describes experimental studies to understand the structure of biocompatible pH responsive polymers and their interaction with the biological system in order to design more effective entities for biomedical applications. A systemic approach was used to study the structure and biological interaction of pH responsive biocompatible poly (L-lysine iso-phthalamide) (PLP) polymer and its derivatives. Poly (L-lysine isophalamide) is a unique polymer that contains pendant carboxylate group and modification with phenylalanine was able to enhance the intracellular delivery efficiency of the polymer. However, the exact structure and mechanism of action remains mostly unknown. In this study, a variety of modifiers was used to synthesise new PLP derivatives in order to elucidate their effect on the polymer structure and other functional characteristics. New characterisation methods including circular dichroism and small angle neutron scattering were introduced to provide more detailed information on the polymer structure and evidence to explain the polymer-membrane interaction. It was determined that PLP adopted a helical structure in solution and that the ability of the PLP- derivative to from a lamellar structure in solution would lead to enhanced intracellular delivery effectiveness. Chirality of the PLP components and modifiers were also examined. Three PLP enantiomers and four phenylalanine modified PLP were synthesised and characterised. The polymers were determined to be chemically identical and had comparable functionalities. However, it was proven again that the ability for polymer to form lamellar structure would result in enhanced intracellular delivery efficiency. The structural and functional information was later used to better design a drug delivery system for the cryopreservation of mammalian cells. The approach was successful, as the resulting vitamin E modified polymer was able to achieve similar cryosurvival rate with trehalose as cryoprotectant compared the gold standard DMSO protocol. The success marked the importance of application-specific design and understanding of drug delivery systems.

Subjects/Keywords: pH-responsive polymers; Intracellular Delivery; Polymer synthesis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chen, A. (2019). The engineering and development of pH-responsive biopolymers for drug delivery applications. (Doctoral Dissertation). University of Cambridge. Retrieved from https://doi.org/10.17863/CAM.45789 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.792983

Chicago Manual of Style (16^th Edition):

Chen, Alexander. “The engineering and development of pH-responsive biopolymers for drug delivery applications.” 2019. Doctoral Dissertation, University of Cambridge. Accessed January 16, 2021. https://doi.org/10.17863/CAM.45789 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.792983.

MLA Handbook (7^th Edition):

Chen, Alexander. “The engineering and development of pH-responsive biopolymers for drug delivery applications.” 2019. Web. 16 Jan 2021.

Vancouver:

Chen A. The engineering and development of pH-responsive biopolymers for drug delivery applications. [Internet] [Doctoral dissertation]. University of Cambridge; 2019. [cited 2021 Jan 16]. Available from: https://doi.org/10.17863/CAM.45789 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.792983.

Council of Science Editors:

Chen A. The engineering and development of pH-responsive biopolymers for drug delivery applications. [Doctoral Dissertation]. University of Cambridge; 2019. Available from: https://doi.org/10.17863/CAM.45789 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.792983

5. Chen, Alexander. The Engineering and Development of pH-Responsive Biopolymers for Drug Delivery Applications.

Degree: PhD, 2019, University of Cambridge

URL: https://www.repository.cam.ac.uk/handle/1810/298733

► This dissertation describes experimental studies to understand the structure of biocompatible pH responsive polymers and their interaction with the biological system in order to design… (more)

▼ This dissertation describes experimental studies to understand the structure of biocompatible pH responsive polymers and their interaction with the biological system in order to design more effective entities for biomedical applications. A systemic approach was used to study the structure and biological interaction of pH responsive biocompatible poly (L-lysine iso-phthalamide) (PLP) polymer and its derivatives. Poly (L-lysine isophalamide) is a unique polymer that contains pendant carboxylate group and modification with phenylalanine was able to enhance the intracellular delivery efficiency of the polymer. However, the exact structure and mechanism of action remains mostly unknown. In this study, a variety of modifiers was used to synthesise new PLP derivatives in order to elucidate their effect on the polymer structure and other functional characteristics. New characterisation methods including circular dichroism and small angle neutron scattering were introduced to provide more detailed information on the polymer structure and evidence to explain the polymer-membrane interaction. It was determined that PLP adopted a helical structure in solution and that the ability of the PLP- derivative to from a lamellar structure in solution would lead to enhanced intracellular delivery effectiveness. Chirality of the PLP components and modifiers were also examined. Three PLP enantiomers and four phenylalanine modified PLP were synthesised and characterised. The polymers were determined to be chemically identical and had comparable functionalities. However, it was proven again that the ability for polymer to form lamellar structure would result in enhanced intracellular delivery efficiency. The structural and functional information was later used to better design a drug delivery system for the cryopreservation of mammalian cells. The approach was successful, as the resulting vitamin E modified polymer was able to achieve similar cryosurvival rate with trehalose as cryoprotectant compared the gold standard DMSO protocol. The success marked the importance of application-specific design and understanding of drug delivery systems.

Subjects/Keywords: pH-responsive polymers; Intracellular Delivery; Polymer synthesis

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APA (6^th Edition):

Chen, A. (2019). The Engineering and Development of pH-Responsive Biopolymers for Drug Delivery Applications. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/298733

Chicago Manual of Style (16^th Edition):

Chen, Alexander. “The Engineering and Development of pH-Responsive Biopolymers for Drug Delivery Applications.” 2019. Doctoral Dissertation, University of Cambridge. Accessed January 16, 2021. https://www.repository.cam.ac.uk/handle/1810/298733.

MLA Handbook (7^th Edition):

Chen, Alexander. “The Engineering and Development of pH-Responsive Biopolymers for Drug Delivery Applications.” 2019. Web. 16 Jan 2021.

Vancouver:

Chen A. The Engineering and Development of pH-Responsive Biopolymers for Drug Delivery Applications. [Internet] [Doctoral dissertation]. University of Cambridge; 2019. [cited 2021 Jan 16]. Available from: https://www.repository.cam.ac.uk/handle/1810/298733.

Council of Science Editors:

Chen A. The Engineering and Development of pH-Responsive Biopolymers for Drug Delivery Applications. [Doctoral Dissertation]. University of Cambridge; 2019. Available from: https://www.repository.cam.ac.uk/handle/1810/298733

6. Mcclellan, Annie Katherine. Raft Polymerization Of Ph-Responsive, Diblock Copolymers For Nucleic Acid Delivery Vehicles.

Degree: M.S. in Engineering Science, Chemical Engineering, 2016, University of Mississippi

URL: https://egrove.olemiss.edu/etd/398

► Since the development of gene therapy, a variety of non-viral nucleic acid delivery vehicles have been prepared and studied for their transfection efficiencies. Recently, polymeric… (more)

Subjects/Keywords: Gene Delivery; Ph-Responsive; Raft; Polymer Chemistry

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APA (6^th Edition):

Mcclellan, A. K. (2016). Raft Polymerization Of Ph-Responsive, Diblock Copolymers For Nucleic Acid Delivery Vehicles. (Thesis). University of Mississippi. Retrieved from https://egrove.olemiss.edu/etd/398

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mcclellan, Annie Katherine. “Raft Polymerization Of Ph-Responsive, Diblock Copolymers For Nucleic Acid Delivery Vehicles.” 2016. Thesis, University of Mississippi. Accessed January 16, 2021. https://egrove.olemiss.edu/etd/398.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mcclellan, Annie Katherine. “Raft Polymerization Of Ph-Responsive, Diblock Copolymers For Nucleic Acid Delivery Vehicles.” 2016. Web. 16 Jan 2021.

Vancouver:

Mcclellan AK. Raft Polymerization Of Ph-Responsive, Diblock Copolymers For Nucleic Acid Delivery Vehicles. [Internet] [Thesis]. University of Mississippi; 2016. [cited 2021 Jan 16]. Available from: https://egrove.olemiss.edu/etd/398.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mcclellan AK. Raft Polymerization Of Ph-Responsive, Diblock Copolymers For Nucleic Acid Delivery Vehicles. [Thesis]. University of Mississippi; 2016. Available from: https://egrove.olemiss.edu/etd/398

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Queens University

7. Cruz, Cyndy Grace. pH- Triggered Dynamic Molecular Tweezers for Drug Delivery Applications .

Degree: Chemistry, 2011, Queens University

URL: http://hdl.handle.net/1974/6829

► My MSc project aims at developing pH-responsive molecular tweezers for drug delivery applications. The project began with the synthesis of our 2nd generation tweezer, whose… (more)

▼ My MSc project aims at developing pH-responsive molecular tweezers for drug delivery applications. The project began with the synthesis of our 2nd generation tweezer, whose main objective was to improve our previous model, 1st generation tweezer, which contained a pH-responsive triad spacer and two naphthalene walls known to interact with hydrophobic drugs such as Mitoxantrone®. The naphthalene interaction sites were successfully modified to contain oligoethylene glycol chains to improve their water-solubility, in anticipation for more accurate measurements of pKa and binding constants in aqueous media. However, all attempts to convert such naphthalene derivatives into their corresponding boronic acid or ester through standard protocols (halogen-lithium exchange, palladium catalyzed borylation) failed. Without the required boronic acid/ester, the final Suzuki-Miyaura coupling with the di-bromo triad spacer was not achieved. Synthesis of the 3rd generation tweezer, which was modified to contain theophylline as the new interaction sites, was then attempted. The half-tweezer was successfully synthesized via copper (II) catalyzed coupling of theophylline with the 5-bromo-4-methoxyphenyl boronic acid. However, all attempts to convert it into the required boronic acid/ ester for the final Suzuki- Miyaura coupling reaction with 2,6-dibromopyridine failed. We then focused our attention on the conversion of the triad spacer into its corresponding diboronic acid. The synthesis of the triad diboronic acid was a success, however, the final copper (II) catalyzed reaction with theophylline to form the tweezer only yielded the mono-coupled product. Lastly, our 4th generation tweezer was engineered to avoid the synthetic difficulties encountered in the boronic acid/ ester synthesis stage. Using the commercially available 5-formyl-2-methoxyphenylboronic acid and o-phenylenediamine, we successfully synthesized a benzimidazole-derived “half tweezer” through ring condensation reaction. Alkylation of this half-tweezer was also successfully achieved, although purification of the alkylated product was not optimized. Using this crude product, we carried out the final tweezer reaction via Suzuki- Miyaura coupling with 2,6-dibromopyridine under microwave irradiation. 1H NMR results show formation of new species that is believed to be the 4th generation tweezer (although the presence of impurities made integration of the signals unreliable). Much work is needed in the purification of the alkylated half tweezer boronic acid in order to avoid complicated mixtures in the final tweezer reaction.

Subjects/Keywords: Molecular Tweezer ; pH responsive ; Drug Delivery

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cruz, C. G. (2011). pH- Triggered Dynamic Molecular Tweezers for Drug Delivery Applications . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/6829

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cruz, Cyndy Grace. “pH- Triggered Dynamic Molecular Tweezers for Drug Delivery Applications .” 2011. Thesis, Queens University. Accessed January 16, 2021. http://hdl.handle.net/1974/6829.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cruz, Cyndy Grace. “pH- Triggered Dynamic Molecular Tweezers for Drug Delivery Applications .” 2011. Web. 16 Jan 2021.

Vancouver:

Cruz CG. pH- Triggered Dynamic Molecular Tweezers for Drug Delivery Applications . [Internet] [Thesis]. Queens University; 2011. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/1974/6829.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cruz CG. pH- Triggered Dynamic Molecular Tweezers for Drug Delivery Applications . [Thesis]. Queens University; 2011. Available from: http://hdl.handle.net/1974/6829

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas – Austin

8. Knipe, Jennifer Marie. Multi-responsive microencapsulated nanogels for the oral delivery of small interfering RNA.

Degree: PhD, Chemical Engineering, 2014, University of Texas – Austin

URL: http://hdl.handle.net/2152/46514

► Multi-responsive, anionic poly(methacrylic acid-co-N-vinyl-2-pyrrolidone) microscale hydrogels (microgels) encapsulating polycationic nanoscale hydrogels (nanogels) were synthesized with either degradable or nondegradable crosslinks. The pH-responsive volume phase transition… (more)

▼ Multi-responsive, anionic poly(methacrylic acid-co-N-vinyl-2-pyrrolidone) microscale hydrogels (microgels) encapsulating polycationic nanoscale hydrogels (nanogels) were synthesized with either degradable or nondegradable crosslinks. The pH-responsive volume phase transition of these formulations was consistent with the pH transition experienced during intestinal delivery, as the hydrogels swelled at pH values greater than pH 5. The physicochemical characteristics of the nondegradable formulations were evaluated by microscopy, potentiometric titration, Fourier transform infrared spectroscopy, and thermal gravimetric analysis. The nondegradable formulations successfully loaded and released a model protein in physiological buffers, but the ability of the microgels to release the nanogels upon exposure to intestinal conditions was inadequate. Therefore, microgels containing enzyme-degradable oligopeptide crosslinks were synthesized then characterized using Fourier transform infrared spectroscopy, electron microscopy, confocal microscopy, and ImageStream flow cytometry. Degradation of the microgels upon incubation in trypsin solutions, simulated gastric fluid, or simulated intestinal fluid was evaluated by measuring the change in relative turbidity over time. Microgels were degraded specifically by the enzyme trypsin, and the rate of degradation was dependent upon the microgel to trypsin concentration ratio; for all ratios tested, degradation was complete within 4 hours. The cytocompatibility of the enzyme-degraded microgels encapsulating nanogels was evaluated in both a human and a murine cell line; at microgel concentrations less than 0.4 mg/ml the cell viability was greater than 90%. Confocal microscopy was used to obtain Z-stack images of the cells following incubation with the microgels, confirming that nanogels were released from the degraded microgels and subsequently inteRNAlized by RAW 264.7 murine macrophage cells. The microencapsulated nanogels were able to load siRNA via electrostatic complexation with loading efficiencies ranging from 60-80%. Incubation of loaded microgels in simulated intestinal fluid with reduced trypsin concentrations or in rat intestinal fluid resulted in successful degradation of the microgel matrix and release of a detectable amount of viable siRNA. The degraded microgels with nanogels transfected the two different cell lines with up to 20% silencing efficiency. Though the knockdown efficiency is not as high as that of nanogels alone, the microgel results are consistent and reproducible across two cell lines. Advisors/Committee Members: Peppas, Nicholas A., 1948- (advisor), Paul, Donald (committee member), Ellison, Christopher (committee member), Contreras, Lydia (committee member), Suggs, Laura (committee member).

Subjects/Keywords: Hydrogel; Oral delivery; Ph-responsive; Biodegradable; SiRNA

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APA (6^th Edition):

Knipe, J. M. (2014). Multi-responsive microencapsulated nanogels for the oral delivery of small interfering RNA. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/46514

Chicago Manual of Style (16^th Edition):

Knipe, Jennifer Marie. “Multi-responsive microencapsulated nanogels for the oral delivery of small interfering RNA.” 2014. Doctoral Dissertation, University of Texas – Austin. Accessed January 16, 2021. http://hdl.handle.net/2152/46514.

MLA Handbook (7^th Edition):

Knipe, Jennifer Marie. “Multi-responsive microencapsulated nanogels for the oral delivery of small interfering RNA.” 2014. Web. 16 Jan 2021.

Vancouver:

Knipe JM. Multi-responsive microencapsulated nanogels for the oral delivery of small interfering RNA. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2014. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/2152/46514.

Council of Science Editors:

Knipe JM. Multi-responsive microencapsulated nanogels for the oral delivery of small interfering RNA. [Doctoral Dissertation]. University of Texas – Austin; 2014. Available from: http://hdl.handle.net/2152/46514

9. 이, 혜림. Stimuli responsive nanoparticles release piperlongumine to inhibit pulmonary metastasis of colorectal carcinoma cells.

Degree: 2018, Ajou University

URL: http://repository.ajou.ac.kr/handle/201003/16549 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000027968

►

Redox-responsive nanoparticles having a diselenide linkage were synthesized to target pulmonary metastasis of cancer cells. Methoxy poly (ethylene glycol)-grafted chitosan (ChitoPEG) was crosslinked using selenocystine-acetyl… (more)

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Redox-responsive nanoparticles having a diselenide linkage were synthesized to target pulmonary metastasis of cancer cells. Methoxy poly (ethylene glycol)-grafted chitosan (ChitoPEG) was crosslinked using selenocystine-acetyl histidine (Ac-histidine) conjugates (ChitoPEGse) for stimuli-responsive delivery of piperlongumine (PL). ChitoPEGse nanoparticles swelled in an acidic environment and became partially disintegrated in the presence of H2O2 10mM, resulting in an increase of particle size and in a size distribution having multimodal pattern. PL release increased under acidic conditions and in the presence of H2O2. Uptake of ChitoPEGse nanoparticles (PL NP) showed similar anticancer activity in vitro against A549 and CT26 cells compared to PL itself. PL NP showed superior anticancer and anti-metastatic activity in an in vivo CT26 cell pulmonary metastasis mouse model. Furthermore, an immunofluorescence imaging study demonstrated that PL NP conjugates were specifically delivered to the tumor mass in the lung. Conclusively, ChitoPEGse nanoparticles were able to be delivered and released to cancer cells with an acidic- or redox state-sensitive manner and then were selectively targeted to pulmonary metastasis of cancer cells since ChitoPEGse nanoparticles have both pH- and redox-responsiveness.

이 연구는 약물 전달 매체인 나노입자 기반의 자극-반응성 약물 전달시스템을 이용하여 piperlongumine(PL)의 암 세포 폐전이 표적 항암효과를 보고자 하였다. Piperlongumine는 인도 남부와 동남아시아에서 발견되는 고추 식물 (Piper longum)의 열매를 구성하는 천연 제품으로 GSTP1 유전자를 침묵시켜 항암활성을 가진다고 알려져 있다. 이러한 배경을 바탕으로 diselenide linkage를 갖는 산화-환원 반응 나노입자 (ChitoPGEse nanoparticle ; PL NP)를 합성하여 대장암 세포주인 CT26 세포의 폐전이에 대해 연구하였다. 합성한 ChitoPEGse nanoparticle의 약물 전달을 보고자 약물 담지량, pH의 변화 및 ROS 환경에서 확인한 결과 약물의 적은 담지량과 산성 환경 및 ROS 존재에서 나노입자가 터지면서 약물이 더 잘 전달되는 것이 확인되었다. CT26 마우스 대장암 및 A549 사람 폐암 세포주에 대한 PL 및 PL NP의 세포 독성을 알아 본 결과 약물의 농도의 증가에 따라 세포 생존 능력이 점차 감소하는 것으로 항암 활성을 확인하였다. 또한 세포사멸과 관련하여 1차원 전기영동 방법과 면역 형광법을 이용하여 caspase-3을 포함한 다양한 세포사멸 단백질들의 발현을 확인하였다. 또한 암 세포의 전이와 관련하여 약물을 처리 한 결과 PL 및 PLNP의 농도가 높아질수록 억제되는 것이 확인되었다. 동물실험에서는 대장암 세포주 CT26을 정맥 주사 한 후 암세포의 전이를 관찰한 결과 폐로 가장 많이 전이가 되었으며, 암 조직을 만든 후 약물을 처리 한 결과 대조군보다 약물처리 마우스에서 폐 조직이 정상 조직에 가깝게 형태를 이룬 것으로 항암제로써의 활성이 확인되었다. 결론적으로 PL, PL NP는 체외에서 암세포의 세포 사멸을 유도하였고, 체내에서는 대장암 세포에서 폐로 전이 된 암의 활성을 억제하는 역할을 하는 것으로 PL NP가 항암제로써의 유망한 후보로 제안한다.

ABSTRACT ⅰ TABLE OF CONTENTS ⅲ LIST OF FIGURES ⅴ I. INTRODUCTION 1 II. MATERIALS AND METHODS 4 A. Materials 4 B. Synthesis of ChitoPEGse nanocomposite 4 C. Fabrication of PL-incorporated ChitoPEGse nanocomposites 7 D. Characterization of nanoparticles 8 E. Cell culture 8 F. MTT assay 9 G. Wound healing assay 10 H. Western blotting 10 I. Immunofluorescence staining 11 J. In vivo CT26 pulmonary metastasis model 12 K. Fluorescence imaging of solid tumor-bearing mice 13 L. Immunohistochemistry 13 M. Statistical analysis 14 III. RESULTS 15 A. Synthesis of ChitoPEGse copolymer 15 B. Fabrication of ChitoPEGse nanoparticles and incorporation of PL 16 C. In vitro cell culture experiment 20 D. In vivo study using pulmonary metastasis model 22…

Advisors/Committee Members: 대학원 의생명과학과, 200824284, 이, 혜림.

Subjects/Keywords: pH responsive; Redox responsive; Core-cross linked nanoparticle; Diselenium; Reactive oxygen species; Piperlogumine; pH-; ROS; 디셀레이드 연결; 핵 융합 나노입자

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

이, �. (2018). Stimuli responsive nanoparticles release piperlongumine to inhibit pulmonary metastasis of colorectal carcinoma cells. (Thesis). Ajou University. Retrieved from http://repository.ajou.ac.kr/handle/201003/16549 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000027968

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

이, 혜림. “Stimuli responsive nanoparticles release piperlongumine to inhibit pulmonary metastasis of colorectal carcinoma cells.” 2018. Thesis, Ajou University. Accessed January 16, 2021. http://repository.ajou.ac.kr/handle/201003/16549 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000027968.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

이, 혜림. “Stimuli responsive nanoparticles release piperlongumine to inhibit pulmonary metastasis of colorectal carcinoma cells.” 2018. Web. 16 Jan 2021.

Vancouver:

이 �. Stimuli responsive nanoparticles release piperlongumine to inhibit pulmonary metastasis of colorectal carcinoma cells. [Internet] [Thesis]. Ajou University; 2018. [cited 2021 Jan 16]. Available from: http://repository.ajou.ac.kr/handle/201003/16549 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000027968.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

이 �. Stimuli responsive nanoparticles release piperlongumine to inhibit pulmonary metastasis of colorectal carcinoma cells. [Thesis]. Ajou University; 2018. Available from: http://repository.ajou.ac.kr/handle/201003/16549 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000027968

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

10. El Asmar, Arlette. Synthèse et caractérisation de systèmes micellaires stimuli-sensibles à partir d’huile de lin : Synthesis and characterisation of stimuli-responsives micellar systems from linseed oil.

Degree: Docteur es, Chimie macromoléculaire, 2017, Normandie

URL: http://www.theses.fr/2017NORMIR19

►

L'intérêt des copolymères amphiphiles se retrouve dans de multiples applications telles que le: supports catalytique, la bio-séparation ou encore la vectorisation de principe actif. L'étude… (more)

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L'intérêt des copolymères amphiphiles se retrouve dans de multiples applications telles que le: supports catalytique, la bio-séparation ou encore la vectorisation de principe actif. L'étude de leu auto-association sous forme micellaire est très étendue notamment via l'utilisation de polymère: intelligents. Cette classe de polymères présente un changement de comportement lors d'un modification de son environnement. Ainsi des polymères pH et thermo-sensibles ont été sélectionnés dans le but d'étudier des systèmes micellaires composés d'un cœur hydrophobe issus de l'huile de lin et d'une couronne hydrophile stimuli-sensible. Cependant, pour chaque application visée, la synthèse de macromolécules de composition et/ou d'architecture complexe possédant de nouvelles propriétés est nécessaire. Afin de contourner les limitations de cette approche, uni alternative reposant sur le mélange physique de copolymères a été étudiée dans le but de moduler les propriétés et combiner deux sensibilités.

Amphiphilic copolymers have attracted a large interest as they find numerous applications in catalyst support, bio-separation devices and drug delivery systems. Their auto-association in aqueous media forming micelles are well-studied, particularly by the use of smart polymers which display a significant physicochemical change in response to modification of their environment. In this work, pH and temperature responsive polymers have been studied for the elaboration of micellar systems composed of a hydrophobic core from linseed oil and hydrophilic stimuli-sensitive coronna. However the common approach is to design one specific macromolecule for one given application, with sometimes complex composition and/or architecture. We aim to investigate a straight-forward pathway towards micellar systems with finely tuned sensitivities by the cooperative self-assembly of two different copolymers to manipulate the physico-chemical behavior of the final mixed system.

Advisors/Committee Members: Burel, Fabrice (thesis director).

Subjects/Keywords: PH-sensible; Thermo-sensible; Micelles mixtes; Huile de lin; Ph-Responsive; Thermo-responsive; Mixed micelles; Linseed oil

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

El Asmar, A. (2017). Synthèse et caractérisation de systèmes micellaires stimuli-sensibles à partir d’huile de lin : Synthesis and characterisation of stimuli-responsives micellar systems from linseed oil. (Doctoral Dissertation). Normandie. Retrieved from http://www.theses.fr/2017NORMIR19

Chicago Manual of Style (16^th Edition):

El Asmar, Arlette. “Synthèse et caractérisation de systèmes micellaires stimuli-sensibles à partir d’huile de lin : Synthesis and characterisation of stimuli-responsives micellar systems from linseed oil.” 2017. Doctoral Dissertation, Normandie. Accessed January 16, 2021. http://www.theses.fr/2017NORMIR19.

MLA Handbook (7^th Edition):

El Asmar, Arlette. “Synthèse et caractérisation de systèmes micellaires stimuli-sensibles à partir d’huile de lin : Synthesis and characterisation of stimuli-responsives micellar systems from linseed oil.” 2017. Web. 16 Jan 2021.

Vancouver:

El Asmar A. Synthèse et caractérisation de systèmes micellaires stimuli-sensibles à partir d’huile de lin : Synthesis and characterisation of stimuli-responsives micellar systems from linseed oil. [Internet] [Doctoral dissertation]. Normandie; 2017. [cited 2021 Jan 16]. Available from: http://www.theses.fr/2017NORMIR19.

Council of Science Editors:

El Asmar A. Synthèse et caractérisation de systèmes micellaires stimuli-sensibles à partir d’huile de lin : Synthesis and characterisation of stimuli-responsives micellar systems from linseed oil. [Doctoral Dissertation]. Normandie; 2017. Available from: http://www.theses.fr/2017NORMIR19

Delft University of Technology

11. Soons, Sophie (author). Photo-patterned, pH-responsive hydrogel membranes for integrated fluid control.

Degree: 2018, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:dacc2ce3-99e5-46dd-ac9e-1aec82e447cb

►

To control fluid transport, microfluidic systems often make use of pressure driven flow and pneumatically actuated valves. However these require bulky external instrumentation. An integrated… (more)

▼

To control fluid transport, microfluidic systems often make use of pressure driven flow and pneumatically actuated valves. However these require bulky external instrumentation. An integrated fluid control mechanism would make microfluidic systems more portable, closed and automated. The aim of this project was to create a pH-responsive membrane for integrated fluid control in microfluidic systems. pH-responsiveness will allow the membrane to interact directly with analytes in a microfluidic system. First pH-responsive materials and fluid control mechanisms to create a pH-responsive membrane were reviewed. Cross-linked polymer hydrogels with pH-dependent volumetric swelling were identified as the most suitable material for the membrane. These materials respond to changes in pH by large volumetric transitions, which creates potential for control over a wide range of flow rates. Furthermore they have an inherent interaction with water and are permeable to small molecules such as H+ ions. The material is synthesized from a liquid precursor that can be cured through photo-initiated free radical polymerization. We tested a system for measuring the pH response of the material that consisted of a hydrogel disk that was vertically constrained inside a fluidic channel. Due to this constraint, expansion only occurred in the lateral direction and could be measured using an optical microscope. Furthermore, we developed a method for manufacturing macro-porous hydrogel membranes that gives control over pore size, shape and position. A photo-lithography approach was used to pattern the membranes and thereby create pores, using a photo-mask that was manufactured on an office printer in a very fast and low-cost process. The resulting membranes had a thickness of 140-190 um and pore diameters of 100-400 um. The pore size was measured for environmental pH of 1.6 and 7.1, within this range the pores doubled in diameter. Furthermore the pH-responsive deformation ratio of the pores increased significantly with increasing curing time and decreasing pore diameter. The results suggest that there is a difference in material properties around the pores that develops due to a local difference in received exposure dose during curing. The fluidic properties and pH-response of the membrane can be adjusted to suit a specific application by changing the design, the curing time or the chemical composition of the membrane. The constrained disk system can then be used to measure and compare the pH-response of different potential materials.

Micro and Nano Engineering

Advisors/Committee Members: Sasso, Luigi (mentor), Fanzio, Paola (mentor), Staufer, Urs (graduation committee), Langelaar, Matthijs (graduation committee), Delft University of Technology (degree granting institution).

Subjects/Keywords: Membrane; Porous membrane; Hydrogel; microfluidics; pH-responsive; pH-sensitive; smart materials; active materials

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Soons, S. (. (2018). Photo-patterned, pH-responsive hydrogel membranes for integrated fluid control. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:dacc2ce3-99e5-46dd-ac9e-1aec82e447cb

Chicago Manual of Style (16^th Edition):

Soons, Sophie (author). “Photo-patterned, pH-responsive hydrogel membranes for integrated fluid control.” 2018. Masters Thesis, Delft University of Technology. Accessed January 16, 2021. http://resolver.tudelft.nl/uuid:dacc2ce3-99e5-46dd-ac9e-1aec82e447cb.

MLA Handbook (7^th Edition):

Soons, Sophie (author). “Photo-patterned, pH-responsive hydrogel membranes for integrated fluid control.” 2018. Web. 16 Jan 2021.

Vancouver:

Soons S(. Photo-patterned, pH-responsive hydrogel membranes for integrated fluid control. [Internet] [Masters thesis]. Delft University of Technology; 2018. [cited 2021 Jan 16]. Available from: http://resolver.tudelft.nl/uuid:dacc2ce3-99e5-46dd-ac9e-1aec82e447cb.

Council of Science Editors:

Soons S(. Photo-patterned, pH-responsive hydrogel membranes for integrated fluid control. [Masters Thesis]. Delft University of Technology; 2018. Available from: http://resolver.tudelft.nl/uuid:dacc2ce3-99e5-46dd-ac9e-1aec82e447cb

Vanderbilt University

12. Kilchrist, Kameron V. Mechanism of Enhanced Cellular Uptake and Cytosolic Retention of MK2 Inhibitory Peptide Nano-polyplexes.

Degree: MS, Biomedical Engineering, 2016, Vanderbilt University

URL: http://hdl.handle.net/1803/11645

► Electrostatic complexation of a cationic MAPKAP kinase 2 inhibitory (MK2i) peptide with the anionic, pH-responsive polymer poly(propylacrylic acid) (PPAA) yields MK2i nano-polyplexes (MK2i-NPs) that significantly… (more)

Subjects/Keywords: macropinocytosis; pH-responsive; endosome escape; nanoparticle; Drug delivery; vascular therapeutic

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APA (6^th Edition):

Kilchrist, K. V. (2016). Mechanism of Enhanced Cellular Uptake and Cytosolic Retention of MK2 Inhibitory Peptide Nano-polyplexes. (Thesis). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/11645

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kilchrist, Kameron V. “Mechanism of Enhanced Cellular Uptake and Cytosolic Retention of MK2 Inhibitory Peptide Nano-polyplexes.” 2016. Thesis, Vanderbilt University. Accessed January 16, 2021. http://hdl.handle.net/1803/11645.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kilchrist, Kameron V. “Mechanism of Enhanced Cellular Uptake and Cytosolic Retention of MK2 Inhibitory Peptide Nano-polyplexes.” 2016. Web. 16 Jan 2021.

Vancouver:

Kilchrist KV. Mechanism of Enhanced Cellular Uptake and Cytosolic Retention of MK2 Inhibitory Peptide Nano-polyplexes. [Internet] [Thesis]. Vanderbilt University; 2016. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/1803/11645.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kilchrist KV. Mechanism of Enhanced Cellular Uptake and Cytosolic Retention of MK2 Inhibitory Peptide Nano-polyplexes. [Thesis]. Vanderbilt University; 2016. Available from: http://hdl.handle.net/1803/11645

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Penn State University

13. Kim, Sung ho. An Engineered Clay Soil System Using Functional Polymers .

Degree: 2011, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/12465

► Soil modification is widely accepted to improve soil properties in the field of geotechnical and geoenvironmental engineering. In the case of clay soil, it is… (more)

Subjects/Keywords: clay; pH-responsive polymer; clay-polymer nanocomposites; DPD

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APA (6^th Edition):

Kim, S. h. (2011). An Engineered Clay Soil System Using Functional Polymers . (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/12465

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kim, Sung ho. “An Engineered Clay Soil System Using Functional Polymers .” 2011. Thesis, Penn State University. Accessed January 16, 2021. https://submit-etda.libraries.psu.edu/catalog/12465.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kim, Sung ho. “An Engineered Clay Soil System Using Functional Polymers .” 2011. Web. 16 Jan 2021.

Vancouver:

Kim Sh. An Engineered Clay Soil System Using Functional Polymers . [Internet] [Thesis]. Penn State University; 2011. [cited 2021 Jan 16]. Available from: https://submit-etda.libraries.psu.edu/catalog/12465.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kim Sh. An Engineered Clay Soil System Using Functional Polymers . [Thesis]. Penn State University; 2011. Available from: https://submit-etda.libraries.psu.edu/catalog/12465

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Otago

14. Lee, Keeho (Arnold). pH responsive nanoparticles as versatile carriers for cancer chemotherapy and vaccination .

Degree: University of Otago

URL: http://hdl.handle.net/10523/8460

► Cancer is one of the leading causes of mortality and morbidity in the Western world. The anguish caused by cancer is exacerbated by current chemotherapeutic… (more)

▼ Cancer is one of the leading causes of mortality and morbidity in the Western world. The anguish caused by cancer is exacerbated by current chemotherapeutic treatments as severe adverse effects can be caused by off-target cytotoxicity against some healthy tissues. This limits the patients these drugs can be used in and importantly the doses that can be used, impacting on therapeutic efficacy. Therefore, tumour specific delivery of cytotoxic agents by environmentally sensitive nanoparticles to minimise off-target effects may be an effective strategy. Another approach to treat cancer would be to utilise a patient’s immune system to more naturally treat cancer. However such immunotherapies have struggled to produce effective results as a comprehensive review of cancer vaccines demonstrated an overall response rate (as defined as the shrinkage of the tumour) of 3.6% (1). One of the challenges with cancer vaccines is the inefficient and ill-defined process of ‘cross-presentation’ which occurs rarely in antigen presenting cells. As cross-presentation is involved in the production of anti-cancer cytotoxic T cell responses, the delivery of antigen directly to the cytoplasm to bypass cross-presentation has been suggested as a strategy to improve vaccine efficacy. Two strategies and nanoparticle formulations were investigated in this thesis where the release of therapeutic agents in acidic conditions was desired. In the first strategy, a formulation of pH responsive polymeric nanoparticles using PDMS-b-PDMAEMA was examined. This polymer was previously reported by Car et al. (2) due to the pH dependent ionisation of PDMAEMA. This ionisation is hypothesised to destabilise the nanoparticle in acidic conditions to release loaded chemotherapy agents, such as doxorubicin (DOX), in the acidic tumour microenvironment for tumour specific DOX release. Secondly, liposomes modified with polyethyleneimine (PEI) and cyclodextrin based ion channels were developed. PEI confers pH responsive release from liposomes due to the ‘proton sponge effect’. The effect occurs when liposomes are internalised within the acidic endosomes of cells, and the buffering effect of PEI leads to an increase in counterion concentration within the liposomes and endosomes. This increase in ion concentration results in osmotic lysis of endosomes and liposomes resulting in release of actives into the cytoplasm. Cyclodextrin ion channels, previously reported by Chui et al. (3), were included in the formulation to facilitate the movement of ions across the liposomal membrane to allow the effect to occur. Delivery of DOX and an immunotherapeutic vaccine combined with an immunostimulant, 5,6-dimethylxanthenone-4-acetic acid (DMXAA) was examined. Both types of nanoparticles were produced by the thin film hydration method. Uptake and release in vitro was determined using a light scattering based assay. Cell culture with murine melanoma cells and an in vivo murine melanoma model were utilised to assess biological activity. PDMS-b-PDMAEMA nanoparticles demonstrated… Advisors/Committee Members: Hook, Sarah (advisor).

Subjects/Keywords: Cancer vaccine; Nanoparticles; pH responsive

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lee, K. (. (n.d.). pH responsive nanoparticles as versatile carriers for cancer chemotherapy and vaccination . (Doctoral Dissertation). University of Otago. Retrieved from http://hdl.handle.net/10523/8460

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Chicago Manual of Style (16^th Edition):

Lee, Keeho (Arnold). “pH responsive nanoparticles as versatile carriers for cancer chemotherapy and vaccination .” Doctoral Dissertation, University of Otago. Accessed January 16, 2021. http://hdl.handle.net/10523/8460.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

MLA Handbook (7^th Edition):

Lee, Keeho (Arnold). “pH responsive nanoparticles as versatile carriers for cancer chemotherapy and vaccination .” Web. 16 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Lee K(. pH responsive nanoparticles as versatile carriers for cancer chemotherapy and vaccination . [Internet] [Doctoral dissertation]. University of Otago; [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10523/8460.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Council of Science Editors:

Lee K(. pH responsive nanoparticles as versatile carriers for cancer chemotherapy and vaccination . [Doctoral Dissertation]. University of Otago; Available from: http://hdl.handle.net/10523/8460

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Western Kentucky University

15. Karim, Ali Esmail. A pH Switchable Responsive Surface for the Trapping And Release of a Hydrophobic Substance.

Degree: MS, Department of Chemistry, 2015, Western Kentucky University

URL: https://digitalcommons.wku.edu/theses/1522

► Solid phase extraction is one of the most widely used techniques to trap and release compounds in a solution. A hydrophobic substance will stick… (more)

Subjects/Keywords: pH- switchable; responsive; trap and release; Chemistry; Physical Chemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Karim, A. E. (2015). A pH Switchable Responsive Surface for the Trapping And Release of a Hydrophobic Substance. (Masters Thesis). Western Kentucky University. Retrieved from https://digitalcommons.wku.edu/theses/1522

Chicago Manual of Style (16^th Edition):

Karim, Ali Esmail. “A pH Switchable Responsive Surface for the Trapping And Release of a Hydrophobic Substance.” 2015. Masters Thesis, Western Kentucky University. Accessed January 16, 2021. https://digitalcommons.wku.edu/theses/1522.

MLA Handbook (7^th Edition):

Karim, Ali Esmail. “A pH Switchable Responsive Surface for the Trapping And Release of a Hydrophobic Substance.” 2015. Web. 16 Jan 2021.

Vancouver:

Karim AE. A pH Switchable Responsive Surface for the Trapping And Release of a Hydrophobic Substance. [Internet] [Masters thesis]. Western Kentucky University; 2015. [cited 2021 Jan 16]. Available from: https://digitalcommons.wku.edu/theses/1522.

Council of Science Editors:

Karim AE. A pH Switchable Responsive Surface for the Trapping And Release of a Hydrophobic Substance. [Masters Thesis]. Western Kentucky University; 2015. Available from: https://digitalcommons.wku.edu/theses/1522

University of KwaZulu-Natal

16. Mhule, Danford David. Synthesis of an oleic acid based pH-responsive lipid and its application in nanodelivery of vancomycin.

Degree: 2017, University of KwaZulu-Natal

URL: https://researchspace.ukzn.ac.za/handle/10413/17999

► Antibiotic resistance is a health challenge that can make the most useful antibiotics ineffective against bacterial infections. Stimuli-responsive nano-drug delivery systems can optimize antibiotic delivery… (more)

Subjects/Keywords: Aureus.; PH responsive SLNs.; Antibiotic.; Nanotechnology.; Antibiotic resistance.; Methicillin-resistant S.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mhule, D. D. (2017). Synthesis of an oleic acid based pH-responsive lipid and its application in nanodelivery of vancomycin. (Thesis). University of KwaZulu-Natal. Retrieved from https://researchspace.ukzn.ac.za/handle/10413/17999

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mhule, Danford David. “Synthesis of an oleic acid based pH-responsive lipid and its application in nanodelivery of vancomycin.” 2017. Thesis, University of KwaZulu-Natal. Accessed January 16, 2021. https://researchspace.ukzn.ac.za/handle/10413/17999.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mhule, Danford David. “Synthesis of an oleic acid based pH-responsive lipid and its application in nanodelivery of vancomycin.” 2017. Web. 16 Jan 2021.

Vancouver:

Mhule DD. Synthesis of an oleic acid based pH-responsive lipid and its application in nanodelivery of vancomycin. [Internet] [Thesis]. University of KwaZulu-Natal; 2017. [cited 2021 Jan 16]. Available from: https://researchspace.ukzn.ac.za/handle/10413/17999.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mhule DD. Synthesis of an oleic acid based pH-responsive lipid and its application in nanodelivery of vancomycin. [Thesis]. University of KwaZulu-Natal; 2017. Available from: https://researchspace.ukzn.ac.za/handle/10413/17999

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Newcastle

17. Willott, Joshua David. Advancing our understanding of the physicochemical behaviour of stimuli-responsive polybasic brushes.

Degree: PhD, 2016, University of Newcastle

URL: http://hdl.handle.net/1959.13/1335929

►

Research Doctorate - Doctor of Philosophy (PhD)

Stimuli-responsive polymeric surface coatings, especially polymer brushes, have attracted great interest for deployment in many industrial and biological… (more)

▼

Research Doctorate - Doctor of Philosophy (PhD)

Stimuli-responsive polymeric surface coatings, especially polymer brushes, have attracted great interest for deployment in many industrial and biological applications such as non-stick, anti-fouling and low friction interfaces. Elucidating the nanoscale structure of polymer brush coatings and understanding the physicochemical mechanisms causing their desirable macroscopic behaviour is of great importance. In this thesis I outline advances in our understanding of the physicochemical behaviour of water-soluble, stimuli-responsive weakly basic polyelectrolyte brushes. Weak polybasic brushes consist of ionisable basic monomers and therefore their aqueous solution behaviour is dependent on range of environmental triggers including solution pH and salinity. This thesis also describes the surface-initiated polymerisation of a family weak polybasic brushes using the novel oxygen tolerant activators regenerated by electron transfer (ARGET) variant of traditional atom transfer radical polymerisation (ATRP). This polymerisation technique can be performed in alcohol/water mixtures, at significantly reduced catalyst concentrations, and allows for fine control over resultant brush thickness. The existing polyelectrolyte brush literature is dominated by weak polyacid brushes and so a primary focus of this thesis is to address the paucity of knowledge on polybasic brushes. We investigate the effects of solution pH, salt concentration and salt type on brush solvation and conformation, brush interactions with foreign bodies and internal brush structure and depth profiles. Accordingly, behaviours have been identified that have not previously been predicted theoretically, nor observed experimentally. For example, weak polybasic brush pH-response is not simply the reverse of polyacid brushes as one might initially expect. We find that pH-induced brush swelling and collapse, as studied by <i>in situ</i> ellipsometry and quartz crystal microbalance with dissipation measurements, is directly influenced by monomer hydrophobicity; with brush collapse occurring at faster rates for the more hydrophobic polymers. Moreover, polybasic brushes exhibit substantial specific anion effects, where for polyacid brushes specific cation effects are dominant. Specifically, in the presence of strongly hydrated kosmotropic acetate anions the weakly polybasic brushes remain highly swollen. Yet, for poorly solvated chaotropic thiocyanate anions, significant brush collapse is observed. Polymer volume fraction profiles obtained from neutron reflectometry measurements on the hydrophobic poly(2 diisopropylamino) ethyl methacrylate brush reveal that in the presence of thiocyanate anions, the brush collapses, forming a dense slab of polymer at the substrate surface. While, in the presence of acetate anions the brush is swollen with polymer density gradually decaying out into solution. Numerical self-consistent field simulations display good qualitative agreement with our experimental observations and provide further…

Advisors/Committee Members: University of Newcastle. Faculty of Science & Information Technology, School of Environmental and Life Sciences.

Subjects/Keywords: polyelectrolyte; polybasic brushes; pH; salt concentration; specific ion; responsive

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Willott, J. D. (2016). Advancing our understanding of the physicochemical behaviour of stimuli-responsive polybasic brushes. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1335929

Chicago Manual of Style (16^th Edition):

Willott, Joshua David. “Advancing our understanding of the physicochemical behaviour of stimuli-responsive polybasic brushes.” 2016. Doctoral Dissertation, University of Newcastle. Accessed January 16, 2021. http://hdl.handle.net/1959.13/1335929.

MLA Handbook (7^th Edition):

Willott, Joshua David. “Advancing our understanding of the physicochemical behaviour of stimuli-responsive polybasic brushes.” 2016. Web. 16 Jan 2021.

Vancouver:

Willott JD. Advancing our understanding of the physicochemical behaviour of stimuli-responsive polybasic brushes. [Internet] [Doctoral dissertation]. University of Newcastle; 2016. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/1959.13/1335929.

Council of Science Editors:

Willott JD. Advancing our understanding of the physicochemical behaviour of stimuli-responsive polybasic brushes. [Doctoral Dissertation]. University of Newcastle; 2016. Available from: http://hdl.handle.net/1959.13/1335929

University of Manchester

18. Bird, Robert. pH-responsive, redox-sensitive hollow particles for the repair of load-bearing soft tissue.

Degree: PhD, 2012, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/phresponsive-redoxsensitive-hollow-particles-for-the-repair-of-loadbearing-soft-tissue(e9c6a050-ca1c-4413-b276-54fedf8b7e00).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.564346

► This thesis presents an investigation of pH-responsive, redox-sensitive poly(MMA-co- MAA) and poly(EA-co-MAA) hollow particles for the repair of load-bearing soft tissues, such as articular cartilage… (more)

▼ This thesis presents an investigation of pH-responsive, redox-sensitive poly(MMA-co- MAA) and poly(EA-co-MAA) hollow particles for the repair of load-bearing soft tissues, such as articular cartilage and the intervertebral disc. Hollow particles continue to attract major interest due to their numerous potential applications. The new method for hollow particle preparation presented in this thesis does not require the use of a colloidal template and is well suited for scaling up. Hollow particles were formed using linear poly(MMA-co-MAA) and poly(EA-co-MAA) aliphatic copolymers synthesised using free-radical chain copolymerisation performed in solution. These copolymers were dissolved in dichloromethane using methanol as a cosolvent and emulsified in water. Diffusion of the methanol into the aqueous phase prompts precipitation of the copolymer at the droplet/water interface. The more hydrophobic copolymers containing less MAA showed improved morphology compared to copolymers containing more MAA. Also, poly(EA-co-MAA) hollow particles had a more spherical morphology than poly(MMA-co-MAA) hollow particles with equivalent MAA contents. This was attributed to the lower Tg of the EA structural monomer, which resulted in more flexible particle shells. Unusually, during potentiometric titration of uncrosslinked hollow particles, the pH of the system decreased with increasing neutralisation. This behaviour is thought to be due to the unfolding of copolymer chains, exposing shielded carboxyl groups. The random structure of the copolymers is believed to be necessary for this behaviour. Crosslinked particles became swollen when the pH was increased using buffers. Concentrated dispersions formed self supporting gels, due to steric confinement, at 5 wt.%. The crosslinking process was performed by functionalising with cystamine using carbodiimide chemistry. This introduced disulphide crosslinks; which could be cleaved under reducing conditions at high pH, dissolving the gels. This ability to reduce the hollow particle shells to their constituent linear copolymer chains gives potential for natural removal from the body via extraction by the renal system. pH-triggered loading and release of a hydrophilic dye using crosslinked hollow particles was demonstrated. The similarity of the particle formation process to traditional solvent evaporation also allowed the loading of a hydrophobic dye. However, these particles were not crosslinked so release following swelling could not be investigated. Cystamine-crosslinked systems suffered from degradation due to thiol-disulphide exchange at high pH (~ pH 8). Crosslinking of one system was performed using 2-amino ethyl methacrylate (AEM). This introduced covalent, vinyl intra-shell crosslinking; which did not break down at high pH. Additional AEM was also used to allow inter-particle UVcrosslinking to form doubly crosslinked (DX) hollow-particle hydrogels. These gels did not re-disperse in buffer. To our knowledge, this is the first example of a covalent hydrogel formed from pH-responsive hollow…

Subjects/Keywords: 660.6; Colloid; gel; hollow; particle; pH responsive; soft tissue; redox

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bird, R. (2012). pH-responsive, redox-sensitive hollow particles for the repair of load-bearing soft tissue. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/phresponsive-redoxsensitive-hollow-particles-for-the-repair-of-loadbearing-soft-tissue(e9c6a050-ca1c-4413-b276-54fedf8b7e00).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.564346

Chicago Manual of Style (16^th Edition):

Bird, Robert. “pH-responsive, redox-sensitive hollow particles for the repair of load-bearing soft tissue.” 2012. Doctoral Dissertation, University of Manchester. Accessed January 16, 2021. https://www.research.manchester.ac.uk/portal/en/theses/phresponsive-redoxsensitive-hollow-particles-for-the-repair-of-loadbearing-soft-tissue(e9c6a050-ca1c-4413-b276-54fedf8b7e00).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.564346.

MLA Handbook (7^th Edition):

Bird, Robert. “pH-responsive, redox-sensitive hollow particles for the repair of load-bearing soft tissue.” 2012. Web. 16 Jan 2021.

Vancouver:

Bird R. pH-responsive, redox-sensitive hollow particles for the repair of load-bearing soft tissue. [Internet] [Doctoral dissertation]. University of Manchester; 2012. [cited 2021 Jan 16]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/phresponsive-redoxsensitive-hollow-particles-for-the-repair-of-loadbearing-soft-tissue(e9c6a050-ca1c-4413-b276-54fedf8b7e00).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.564346.

Council of Science Editors:

Bird R. pH-responsive, redox-sensitive hollow particles for the repair of load-bearing soft tissue. [Doctoral Dissertation]. University of Manchester; 2012. Available from: https://www.research.manchester.ac.uk/portal/en/theses/phresponsive-redoxsensitive-hollow-particles-for-the-repair-of-loadbearing-soft-tissue(e9c6a050-ca1c-4413-b276-54fedf8b7e00).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.564346

University of Manchester

19. Thaiboonrod, Sineenat. Injectable microgel systems : towards an injectable gel for heart tissue repair.

Degree: PhD, 2014, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/injectable-microgel-systems-towards-an-injectable-gel-for-heart-tissue-repair(cc53a831-327a-4790-802c-e651b87c98d4).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.626889

► This thesis presents an investigation of cationic microgels based on poly(N-vinylformamide-co-glycidyl methacrylate) (PNVF-GMA) and poly(N-vinylformamide-co-2-(N-vinylformamido) ethyl ether) (PNVF-NVEE). They arestudied in the context of future… (more)

▼ This thesis presents an investigation of cationic microgels based on poly(N-vinylformamide-co-glycidyl methacrylate) (PNVF-GMA) and poly(N-vinylformamide-co-2-(N-vinylformamido) ethyl ether) (PNVF-NVEE). They arestudied in the context of future heteroaggregated doubly crosslinked (DX) microgelsfor damaged heart tissue repair. The microgel particles were synthesised fromPNVF-GMA, which is also a water swellable microgel. The PNVF-GMA particleshad a core-shell structure in which PNVF provides the core and PGMA creates thecross-linked shell. The morphology of particles is that of a “cane-ball” like shape. There are interconnected ridges, and this unusual morphology can be controlled bythe weight fraction of GMA used during preparation. The hydrolysed PNVF-GMA(H-PNVF-GMA) particles were both positively and negatively charged. Moreover,charge patch aggregation occurred at low ionic strength. However, these microgelswere colloidally unstable after water rinsing due to shell fragmentation. PNVF microgel particles containing (N-Vinylformamido) ethyl ether (NVEE) as acrosslinking agent were also studied to avoid the fragmentation of the particles. Thismicrogel was hydrolysed in alkali conditions to provide poly(vinylamine-co-bis(ethyl vinylamine) ether) (PVAM-BEVAME), which contains primary aminegroups. It is proposed from the data presented that the content of hydrolysis was veryhigh and the particles were stable after hydrolysis owing to the stability of etherlinkage in NVEE. These microgels were able to swell upon decreasing pH. ThePVAM-BEVAME microgel with 9 mol% of BEVAME was then used to formdoubly crosslinked (DX) microgel. To form the inter-particles crosslinking, the vinylgroups were included by functionalisation using glycidyl methacrylate (GMA)monomer. The vinyl groups of neighbouring particles were linked together via freeradical reaction. The DX microgel formed under physiological temperature andshowed extensive porosity. These DX microgels had good mechanical propertiesconfirmed by high storage modulus (G’). Moreover, the precursor gels wereinjectable which is favourable for future biomaterial applications. The study providesa new family of cationic microgel that may be suitable for a future heteroaggregatedDX microgel for heart tissue repair.

Subjects/Keywords: 610.28; microgel; pH-responsive; injectable gel; cationic microgel

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Thaiboonrod, S. (2014). Injectable microgel systems : towards an injectable gel for heart tissue repair. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/injectable-microgel-systems-towards-an-injectable-gel-for-heart-tissue-repair(cc53a831-327a-4790-802c-e651b87c98d4).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.626889

Chicago Manual of Style (16^th Edition):

Thaiboonrod, Sineenat. “Injectable microgel systems : towards an injectable gel for heart tissue repair.” 2014. Doctoral Dissertation, University of Manchester. Accessed January 16, 2021. https://www.research.manchester.ac.uk/portal/en/theses/injectable-microgel-systems-towards-an-injectable-gel-for-heart-tissue-repair(cc53a831-327a-4790-802c-e651b87c98d4).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.626889.

MLA Handbook (7^th Edition):

Thaiboonrod, Sineenat. “Injectable microgel systems : towards an injectable gel for heart tissue repair.” 2014. Web. 16 Jan 2021.

Vancouver:

Thaiboonrod S. Injectable microgel systems : towards an injectable gel for heart tissue repair. [Internet] [Doctoral dissertation]. University of Manchester; 2014. [cited 2021 Jan 16]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/injectable-microgel-systems-towards-an-injectable-gel-for-heart-tissue-repair(cc53a831-327a-4790-802c-e651b87c98d4).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.626889.

Council of Science Editors:

Thaiboonrod S. Injectable microgel systems : towards an injectable gel for heart tissue repair. [Doctoral Dissertation]. University of Manchester; 2014. Available from: https://www.research.manchester.ac.uk/portal/en/theses/injectable-microgel-systems-towards-an-injectable-gel-for-heart-tissue-repair(cc53a831-327a-4790-802c-e651b87c98d4).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.626889

University of Manchester

20. Tungchaiwattana, Somjit. A study of Particle Structure and Film Formation Mechanism on the Mechanical Properties of Synthetic Rubber Films.

Degree: 2014, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:232661

►

This thesis investigated a new group of poly(Bd)/poly(Bd-co-MAA) core-shell particles that were ionically crosslinked and cast as nanostructured ionomer films from aqueous dispersions. The new… (more)

Subjects/Keywords: poly(Bd)/poly(Bd/MAA), core-shell, thermally triggered, thermoresponsive; microgels, pH responsive

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tungchaiwattana, S. (2014). A study of Particle Structure and Film Formation Mechanism on the Mechanical Properties of Synthetic Rubber Films. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:232661

Chicago Manual of Style (16^th Edition):

Tungchaiwattana, Somjit. “A study of Particle Structure and Film Formation Mechanism on the Mechanical Properties of Synthetic Rubber Films.” 2014. Doctoral Dissertation, University of Manchester. Accessed January 16, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:232661.

MLA Handbook (7^th Edition):

Tungchaiwattana, Somjit. “A study of Particle Structure and Film Formation Mechanism on the Mechanical Properties of Synthetic Rubber Films.” 2014. Web. 16 Jan 2021.

Vancouver:

Tungchaiwattana S. A study of Particle Structure and Film Formation Mechanism on the Mechanical Properties of Synthetic Rubber Films. [Internet] [Doctoral dissertation]. University of Manchester; 2014. [cited 2021 Jan 16]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:232661.

Council of Science Editors:

Tungchaiwattana S. A study of Particle Structure and Film Formation Mechanism on the Mechanical Properties of Synthetic Rubber Films. [Doctoral Dissertation]. University of Manchester; 2014. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:232661

Vanderbilt University

21. Joshi, Rucha Vinay. Smart Microspheres for Stimuli Responsive Drug Delivery, W/O/W double emulsion method, O/W single emulsion method.

Degree: MS, Biomedical Engineering, 2011, Vanderbilt University

URL: http://hdl.handle.net/1803/15231

► Tunable and sustained drug delivery platforms have great unmet potential to be used for more optimal treatment of human disease. Such delivery devices avoid bolus… (more)

▼ Tunable and sustained drug delivery platforms have great unmet potential to be used for more optimal treatment of human disease. Such delivery devices avoid bolus delivery and its undesirable systemic effects and toxicity. Controlled release can also overcome issues related to insufficient local concentrations of drug for the required timeframe since a single injection of naked drug can result in rapid degradation and subsequent distribution throughout the body. Microspheres offer one route for sustained and controlled release that have great potential as ideal platforms to deliver drugs in an optimized, sustained pattern. Many hydrolytically biodegradable microspheres have been pursued (i.e., PLGA). The focus of this thesis work has been on utilization of “smart”, stimuli-responsive polymers that release drugs at a rate dictated by the environment rather than hydrolytic degradation mechanisms that act independent of any environmental cues. For example, we have specifically sought applications for delivery to slightly acidic pH (5-7) tissues in cardiac ischemia and chronic diabetic wounds and to tissues laden with cell-damaging reactive oxygen species (in particular hydrogen peroxide) such as in rheumatoid arthritis. With this idea in mind, we formulated, characterized and studied in vitro release profiles of two novel types of “smart”, stimuli sensitive microspheres. These were pH and temperature-sensitive microspheres made from poly(NIPAAm-co-PAA-co-BA) (NPB microspheres), and Reactive Oxygen Species (ROS)-sensitive microspheres made from poly(propylene) sulfide (PPS microspheres). These “intelligent” microspheres demonstrated sustained release profile of encapsulated drugs when presented with ischemic pH and hydrogen peroxide as stimuli, indicating their potential for spatio-temporally controlled therapeutic delivery to ischemic and inflammatory environments, respectively. NPB microspheres formulated using a water–in–oil-in-water double emulsion method were pursued specifically as candidates to encapsulate hydrophilic drugs (i.e. proteins). The PPS microspheres, on the other hand, were generated using a modified oil-in-water single emulsion method in order to pursue applications for delivery of more hydrophobic (i.e., small molecule) drugs. Advisors/Committee Members: Dr. Hak-Joon Sung (Committee Chair), Dr. Craig L. Duvall (Committee Chair).

Subjects/Keywords: LCST; ROS; temperature; pH; microspheres; stimuli responsive polymers; cumulative release; characterization of microspheres; PPS

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APA (6^th Edition):

Joshi, R. V. (2011). Smart Microspheres for Stimuli Responsive Drug Delivery, W/O/W double emulsion method, O/W single emulsion method. (Thesis). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/15231

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Joshi, Rucha Vinay. “Smart Microspheres for Stimuli Responsive Drug Delivery, W/O/W double emulsion method, O/W single emulsion method.” 2011. Thesis, Vanderbilt University. Accessed January 16, 2021. http://hdl.handle.net/1803/15231.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Joshi, Rucha Vinay. “Smart Microspheres for Stimuli Responsive Drug Delivery, W/O/W double emulsion method, O/W single emulsion method.” 2011. Web. 16 Jan 2021.

Vancouver:

Joshi RV. Smart Microspheres for Stimuli Responsive Drug Delivery, W/O/W double emulsion method, O/W single emulsion method. [Internet] [Thesis]. Vanderbilt University; 2011. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/1803/15231.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Joshi RV. Smart Microspheres for Stimuli Responsive Drug Delivery, W/O/W double emulsion method, O/W single emulsion method. [Thesis]. Vanderbilt University; 2011. Available from: http://hdl.handle.net/1803/15231

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

22. Hills, Katherine Denise. Aptasensor Based Approach for Real-Time Monitoring of Listeria innocua and Listeria monocytogenes.

Degree: MS, Biological and Agricultural Engineering, 2016, Texas A&M University

URL: http://hdl.handle.net/1969.1/156824

► Listeria monocytogenes is one of the most common causes of food illness deaths in the world, with multiple outbreaks in the United States alone. The… (more)

▼ Listeria monocytogenes is one of the most common causes of food illness deaths in the world, with multiple outbreaks in the United States alone. The goal of this study was to design biosensors using aptamers with the capability of rapid detection of this potentially deadly pathogen. The biosensor design process involved the use a nano-metallic hydrid platform consisting of a platinum/graphene/platinum (PGP) and PGP+chitosan nanobrush platforms functionalized with aptamers. Polyclonal goat based anti-Listeria antibodies were also attached to both platforms to test their capabilities as a biosensor and to compare aptamer specificity. The PGP+chitosan sensors were controlled by the pH sensitivity of the chitosan (CHT) brushes. The detection of the target bacteria relied on the sensors’ electrochemical response based on impedance changes caused by the L. innocua or L. monocytogenes attachment onto the bio-recognition agents. Each sensor tested had a detection time of approximately 17 min including 15 min for bacteria capture and approximately 2 min to run EIS test. Capture efficiency tests were performed on the PGP+CHT platform based on brushes actuation with pH to determine the optimum testing conditions. The best testing condition was observed when the electrode was first placed in a pH 5 suspension with bacteria and then tested at pH 7 in PBS. For the PGP platform, the highest ESA value (0.0718 ± 0.029 cm²) found was for the PGP+400 nM thiol aptamer sensor and when impedance testing with bacteria was conducted the highest sensitivity (12.14 ± 1.79 1/log(CFU/mL) and lowest limit of detection (LOD) (11.2 ± 0.79 CFU/mL) value. For the PGP+CHT platform, the best results were found for the PGP+CHT+100 nM aptamer sensor in the presence of L. innocua with a sensitivity of 12.14 ± 1.79 1/log(CFU/mL) and a LOD of 9.1 ± 1.1 CFU/mL. Furthermore, this sensor was able to detect bacteria over a wide range from 10 – 10⁷ CFU/mL. The sensitivity of the PGP+CHT+100 nM aptamer sensor was also measured in the presence of L. innocua and S. aureus suspensions containing equally increasing concentrations and had a sensitivity value of 14.25 ± 1.69 1/log(CFU/mL) and a LOD of 9.4 ± 0.11 CFU/mL. This means that this sensor will be very selective towards Listeria spp. and should only detect these bacteria when in a medium that contains other pathogens. Furthermore, PGP+CHT+bio-recognition agent biosensors were also tested in vegetable broth. The LOD for the PGP+CHT+100 nM aptamer was 31.12 ± 0.64 CFU/mL and the PGP+CHT+200 nM antibody was 23.9 ± 0.96 CFU/mL. The aptamers had a sensitivity of 3.76 ± 0.34 1/log(CFU/mL) and the antibodies had a value of 4.9 ± 0.4 1/log(CFU/mL) which were not statistically significant, implying that other bio-recognition agents could be attached to the PGP+CHT platform and have similar detection capabilities. Both PGP and PGP+CHT sensor platforms were comparable to each other in terms of LOD, sensitivity, and linear range of detection with best results observed for the PGP + 400 nM thiol aptamer and PGP + CHT +… Advisors/Committee Members: Gomes, Carmen (advisor), Castell-Perez, Elena (committee member), Castillo, Alejandro (committee member).

Subjects/Keywords: aptamer; impedimetric biosensor; food safety; chitosan; pH-responsive nanobrushes; graphene-platinum nanostructures

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hills, K. D. (2016). Aptasensor Based Approach for Real-Time Monitoring of Listeria innocua and Listeria monocytogenes. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/156824

Chicago Manual of Style (16^th Edition):

Hills, Katherine Denise. “Aptasensor Based Approach for Real-Time Monitoring of Listeria innocua and Listeria monocytogenes.” 2016. Masters Thesis, Texas A&M University. Accessed January 16, 2021. http://hdl.handle.net/1969.1/156824.

MLA Handbook (7^th Edition):

Hills, Katherine Denise. “Aptasensor Based Approach for Real-Time Monitoring of Listeria innocua and Listeria monocytogenes.” 2016. Web. 16 Jan 2021.

Vancouver:

Hills KD. Aptasensor Based Approach for Real-Time Monitoring of Listeria innocua and Listeria monocytogenes. [Internet] [Masters thesis]. Texas A&M University; 2016. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/1969.1/156824.

Council of Science Editors:

Hills KD. Aptasensor Based Approach for Real-Time Monitoring of Listeria innocua and Listeria monocytogenes. [Masters Thesis]. Texas A&M University; 2016. Available from: http://hdl.handle.net/1969.1/156824

University of Canterbury

23. Kelton, William James. A scalable method for the production of pH responsive polyamide microcapsules for drug delivery.

Degree: Chemical and Process Engineering, 2008, University of Canterbury

URL: http://hdl.handle.net/10092/1988

► A scalable method for the synthesis of polyethylene terephthalamide microcapsules grafted with polyacrylic acid to enable pH responsiveness has been developed. Microcapsules were produced by… (more)

▼ A scalable method for the synthesis of polyethylene terephthalamide microcapsules grafted with polyacrylic acid to enable pH responsiveness has been developed. Microcapsules were produced by interfacial polymerisation of an oil-in-water emulsion in a 2 L batch reactor and subsequently circulated through an external loop reactor for UV irradiative surface grafting. Ungrafted microcapsule samples yielded 1.0 - 1.2 g desiccated capsules per experiment. Initial production trials were subject to severe agglomeration, observed during dialysis of the microcapsules with 30 % (v/v) ethanol solution. Lowering of the terephthaloyl dichloride monomer concentration, to 0.2 mol L⁻¹ in the chloroform / cyclohexane (3 : 1) organic solution, alleviated this unwanted agglomeration. Laser diffraction particle size analysis revealed microcapsules were produced with a 51 µm average diameter. A purpose built external loop irradiation reactor was used to facilitate graft polymerisation of acrylic acid on the microcapsules, using 254 nm UV light at 19 mW cm⁻². Characterisation of the external loop flow regime showed a mild deviation from ideal plug flow, with a vessel dispersion number of 0.014 and a Reynolds number of 1310. Confirmation of monomer polymerisation was ascertained by back titration and Fourier transform infrared spectroscopy. No distinction between homopolymer and grafted polyacrylic acid could be made by these characterisation methods. A Taguchi analysis on variables influencing grafting revealed high temperature to contribute most significantly to graft yield, followed by a long irradiation period. The development of a packed column pulse response method for testing pH response showed a high repeatability. However, release profile testing of a microcapsule slurry with an observed graft yield of 1.13 mmol g⁻¹ did not provide a definitive pH-based release of mPEG 5000 or PEGylated TAMRA dye. Determination of acrylic acid polymerisation kinetics following UV irradiation of the microcapsules is required for future optimisation of a functional graft yield.

Subjects/Keywords: drug delivery; microcapsules; pH responsive polymer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kelton, W. J. (2008). A scalable method for the production of pH responsive polyamide microcapsules for drug delivery. (Thesis). University of Canterbury. Retrieved from http://hdl.handle.net/10092/1988

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kelton, William James. “A scalable method for the production of pH responsive polyamide microcapsules for drug delivery.” 2008. Thesis, University of Canterbury. Accessed January 16, 2021. http://hdl.handle.net/10092/1988.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kelton, William James. “A scalable method for the production of pH responsive polyamide microcapsules for drug delivery.” 2008. Web. 16 Jan 2021.

Vancouver:

Kelton WJ. A scalable method for the production of pH responsive polyamide microcapsules for drug delivery. [Internet] [Thesis]. University of Canterbury; 2008. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10092/1988.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kelton WJ. A scalable method for the production of pH responsive polyamide microcapsules for drug delivery. [Thesis]. University of Canterbury; 2008. Available from: http://hdl.handle.net/10092/1988

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manitoba

24. Kim, Seungil. pH-responsive biomaterials for smart intravaginal drug delivery.

Degree: Biomedical Engineering, 2018, University of Manitoba

URL: http://hdl.handle.net/1993/33210

► For better combating human immunodeficiency virus (HIV), pH-triggered on-demand intravaginal release of anti-HIV drugs or nanocarrier was proposed to avoid unnecessary exposure to drug and… (more)

▼ For better combating human immunodeficiency virus (HIV), pH-triggered on-demand intravaginal release of anti-HIV drugs or nanocarrier was proposed to avoid unnecessary exposure to drug and reduce side effects. Because normal human vaginal tract pH is acidic (3.5-4.5) and can be elevated to neutral by the introduction of seminal fluid during heterosexul intercourse. To acheve the goal, new pH-responsive polyurethanes (PUs) were synthesized from polyethylene glycol (PEG), hexamethylene diisocyanate (HDI), methylene di-p-phenyl diisocyanate (MDI), 1,4-bis(2-hydroxyethyl)piperazine (HEP), dimethylolpropionic acid (DMPA), and propylene glycol (PG) for the fabrication of intravaginal biomaterials. Solvent-cast PEG-HEP-HDI-PG and PEG-HEP-MDI-PG membranes were fabricated and showed pH-triggered reversible changes in swelling ratio and surface morphology. The solvent-cast membranes demonstrated pH-responsive switchable on-and-off release of sodium diclofenac (NaDF): triggered release at pH 7.0 (˃ 10%) but little-to-no release at pH 4.2. Electrospun PEG-HEP-MDI-PG membrane was fabricated for the controlled release of nanocarriers since the solvent-cast PU membranes don’t have sufficient interconnected pores to allow traverse of nanoparticles (NPs). The electrospun membrane demonstrated almost no release of VisiblexTM color dyed polystyrene nanoparticles (PSNs, 200 nm, -COOH) at pH 4.5 (2 ± 1.3%) but a continuous release at pH 7.0 (60 ± 6.2%) for 24 h. These pH-responsive PU membranes were developed as a “window” membrane of reservoir-intravaginal ring (IVR) for the on-demand release of drugs or nanocarriers. The PU membranes did not show noticeable negative impact on viability of VK2/E6E7 human epithelial cells and Sup-T1 human T-cells or induction of pro-inflammatory cytokines (interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-1 beta (IL-1)) production. At last, the pH-triggered switchable release of nanocarriers was achieved by fabricated PEG-DMPA-HDI-PG hydrogel (20 wt% in distilled water). The fluorescent dye, orange II, labeled PEGylated poly(aspartic acid)-based NP (251-283 nm) was synthesized for release study and blended with PU hydrogel to form a supramolecular complex hydrogel. Then the complex hydrogel was filled into the lumen of segmented reservoir-IVRs containing two holes. In vitro release study showed close-to-zero release of NPs at pH 4.2, and then 18.5 ± 5.2% release of NPs for the next 1 h at pH 7.0, followed by the switchable on-and-off release for 5 h. Advisors/Committee Members: Liu, Song (Biosystems Engineering) (supervisor), O'Neil, Joe (Chemistry) .

Subjects/Keywords: Smart drug delivery; Anti-HIV; pH-responsive polyurethanes; Intravaginal Biomaterials; Controlled release of nanoparticles

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kim, S. (2018). pH-responsive biomaterials for smart intravaginal drug delivery. (Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/33210

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kim, Seungil. “pH-responsive biomaterials for smart intravaginal drug delivery.” 2018. Thesis, University of Manitoba. Accessed January 16, 2021. http://hdl.handle.net/1993/33210.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kim, Seungil. “pH-responsive biomaterials for smart intravaginal drug delivery.” 2018. Web. 16 Jan 2021.

Vancouver:

Kim S. pH-responsive biomaterials for smart intravaginal drug delivery. [Internet] [Thesis]. University of Manitoba; 2018. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/1993/33210.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kim S. pH-responsive biomaterials for smart intravaginal drug delivery. [Thesis]. University of Manitoba; 2018. Available from: http://hdl.handle.net/1993/33210

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Delft University of Technology

25. Lauta, Francesca (author). Injectable pH-responsive Ureido-Pyrimidinone (UPy) hydrogel as drug carrier for epicardial activation.

Degree: 2019, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:c815354a-f62c-478d-a1ab-7c774bee7305

►

The presence of a stem cell source in the epicardium that can be stimulated by exogenous delivery of transforming growth factor-β (TGF-β) and migrate towards… (more)

Subjects/Keywords: Epicardium; Myocardial Infarction; Cardiac Repair; Drug Delivery System; TGF-β; Hydrogel; pH-responsive

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APA (6^th Edition):

Lauta, F. (. (2019). Injectable pH-responsive Ureido-Pyrimidinone (UPy) hydrogel as drug carrier for epicardial activation. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:c815354a-f62c-478d-a1ab-7c774bee7305

Chicago Manual of Style (16^th Edition):

Lauta, Francesca (author). “Injectable pH-responsive Ureido-Pyrimidinone (UPy) hydrogel as drug carrier for epicardial activation.” 2019. Masters Thesis, Delft University of Technology. Accessed January 16, 2021. http://resolver.tudelft.nl/uuid:c815354a-f62c-478d-a1ab-7c774bee7305.

MLA Handbook (7^th Edition):

Lauta, Francesca (author). “Injectable pH-responsive Ureido-Pyrimidinone (UPy) hydrogel as drug carrier for epicardial activation.” 2019. Web. 16 Jan 2021.

Vancouver:

Lauta F(. Injectable pH-responsive Ureido-Pyrimidinone (UPy) hydrogel as drug carrier for epicardial activation. [Internet] [Masters thesis]. Delft University of Technology; 2019. [cited 2021 Jan 16]. Available from: http://resolver.tudelft.nl/uuid:c815354a-f62c-478d-a1ab-7c774bee7305.

Council of Science Editors:

Lauta F(. Injectable pH-responsive Ureido-Pyrimidinone (UPy) hydrogel as drug carrier for epicardial activation. [Masters Thesis]. Delft University of Technology; 2019. Available from: http://resolver.tudelft.nl/uuid:c815354a-f62c-478d-a1ab-7c774bee7305

University of Toronto

26. Chang, Hao Han Ricky. Design and Optimization of Nanoparticulate Permeability-Modifiers for pH-independent Drug Release and Alcohol-resistant Dosage Forms.

Degree: 2018, University of Toronto

URL: http://hdl.handle.net/1807/102794

►

Most drugs on the market are either weakly basic or weakly acidic. Their pH-dependent solubility may result in undesired drug release kinetics of modified-release dosage… (more)

Subjects/Keywords: Alcohol resistance; Coated dosage forms; Ethylcellulose; pH-responsive nanoparticles; Pore formers; Terpolymer; 0572

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APA (6^th Edition):

Chang, H. H. R. (2018). Design and Optimization of Nanoparticulate Permeability-Modifiers for pH-independent Drug Release and Alcohol-resistant Dosage Forms. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/102794

Chicago Manual of Style (16^th Edition):

Chang, Hao Han Ricky. “Design and Optimization of Nanoparticulate Permeability-Modifiers for pH-independent Drug Release and Alcohol-resistant Dosage Forms.” 2018. Masters Thesis, University of Toronto. Accessed January 16, 2021. http://hdl.handle.net/1807/102794.

MLA Handbook (7^th Edition):

Chang, Hao Han Ricky. “Design and Optimization of Nanoparticulate Permeability-Modifiers for pH-independent Drug Release and Alcohol-resistant Dosage Forms.” 2018. Web. 16 Jan 2021.

Vancouver:

Chang HHR. Design and Optimization of Nanoparticulate Permeability-Modifiers for pH-independent Drug Release and Alcohol-resistant Dosage Forms. [Internet] [Masters thesis]. University of Toronto; 2018. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/1807/102794.

Council of Science Editors:

Chang HHR. Design and Optimization of Nanoparticulate Permeability-Modifiers for pH-independent Drug Release and Alcohol-resistant Dosage Forms. [Masters Thesis]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/102794

University of Melbourne

27. Karoui, Hedi. Tailor-made covalent organic-inorganic polyoxometalate hybrids: versatile platforms for the elaboration of novel molecular architectures.

Degree: 2018, University of Melbourne

URL: http://hdl.handle.net/11343/213956

► Covalent organic-inorganic polyoxometalate (POM or POMs) hybrids constitute versatile platforms for the elaboration of functional molecular architectures. This Ph.D. research project aimed to synthesize novel… (more)

▼ Covalent organic-inorganic polyoxometalate (POM or POMs) hybrids constitute versatile platforms for the elaboration of functional molecular architectures. This Ph.D. research project aimed to synthesize novel organic-inorganic POM hybrids using pre- and post-functionalization methods. The synthesis of organic-inorganic hybrids starting from POMs, known as direct functionalization, is a well-established synthetic procedure. However, as the complexity of the targeted functional system increases, a multi-step strategy relying on the post-functionalization of preformed hybrid POMs is necessary. Herein, both approaches are explored. Following hybridization of POM surfaces using organic units, ranging from small groups to large polymeric chains, this work provides a significant step forward in the rational design and synthesis of POMs, which permits the elaboration of POM based nanomaterials. At first, boronic acids and esters ligands were selected for POMs’ post-functionalization. Three organoboron functionalized Anderson-Evans and one organoboron functionalized Lindqvist POM were synthesized using Schiff base chemistry; with the general formulas of the Anderson-Evans POM hybrids being [MnIIIMo6VIO18((OCH2)3)CN=CHC6H4(B(OR)2)2]3− (where R = H, Me), [MnIIIMo6VIO18((OCH2)3)CN=CHC6H4(BO2(CH2)3)2]3-, with the formula of the Lindqvist POM hybrid being [VV6O13{(OCH2)3CN=CHC6H4B(OH)2}2]2-. These compounds have been characterized in the solid state by single-crystal X-ray diffraction (XRD), FT-IR spectroscopy and elemental analysis and in solution using Nuclear Magnetic Resonance (NMR) spectroscopy. This work has further been extended to organosilane functionalized mono and di lacunary Keggin POMs. Two organoboron functionalized Keggin POMs were synthesized using N, N'-dicyclohexylcarbodiimide (DCC) coupling; with the general formulas being [β2-SiW11O39{O(Si(CH2)3NHC=O-C12H17BO2)2}]4- and [γ-SiW10O36{O(Si(CH2)3NHC=OC12H17BO2)2}]4-. These compounds have been characterized in the solid state by FT-IR spectroscopy and elemental analysis and in solution using NMR spectroscopy. Later, the employment of microwave-assisted synthesis permitted the generation of novel mixed metal tris(alkoxo)molybdovanadates. The reaction of [β-Mo8O24]4- and [H3V10O28]3- with pentaerythritol or tris(hydroxymethyl)aminomethane yielded compounds with the general formula [V3Mo3O16(O3-R)]2- where R = C5H8OH or C4H6NH2. Post-synthetic esterification of the alcohol derivative yielded the acylated derivative [V3Mo3O16(O3-R)]2- where R = C7H11O2. Single-crystal X-ray Diffraction (XRD), NMR spectroscopy, High-Resolution Mass Spectrometry (HR-MS) and FT-IR spectroscopy have been used in combination to rationalize the structural isomerization observed within these systems. The rational design and synthesis of two novel covalent organic-inorganic hybrid polymers via Atom Transfer Radical Polymerization (ATRP), composed of either a Lindqvist POM macro initiator of formula [V3Mo3O19{(OCH2)3CNHC=OC(CH3)2Br}]2- or an Anderson-Evans POM macro initiator of…

Subjects/Keywords: polyoxometalates; self-assembly; nanoparticles; pH responsive polymers; boronic acids; inorganic chemistry; organic chemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Karoui, H. (2018). Tailor-made covalent organic-inorganic polyoxometalate hybrids: versatile platforms for the elaboration of novel molecular architectures. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/213956

Chicago Manual of Style (16^th Edition):

Karoui, Hedi. “Tailor-made covalent organic-inorganic polyoxometalate hybrids: versatile platforms for the elaboration of novel molecular architectures.” 2018. Doctoral Dissertation, University of Melbourne. Accessed January 16, 2021. http://hdl.handle.net/11343/213956.

MLA Handbook (7^th Edition):

Karoui, Hedi. “Tailor-made covalent organic-inorganic polyoxometalate hybrids: versatile platforms for the elaboration of novel molecular architectures.” 2018. Web. 16 Jan 2021.

Vancouver:

Karoui H. Tailor-made covalent organic-inorganic polyoxometalate hybrids: versatile platforms for the elaboration of novel molecular architectures. [Internet] [Doctoral dissertation]. University of Melbourne; 2018. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/11343/213956.

Council of Science Editors:

Karoui H. Tailor-made covalent organic-inorganic polyoxometalate hybrids: versatile platforms for the elaboration of novel molecular architectures. [Doctoral Dissertation]. University of Melbourne; 2018. Available from: http://hdl.handle.net/11343/213956

University of Canterbury

28. Kelton, William James. A scalable method for the production of pH responsive polyamide microcapsules for drug delivery.

Degree: M. Eng., Chemical Engineering, 2008, University of Canterbury

URL: http://dx.doi.org/10.26021/2160

► A scalable method for the synthesis of polyethylene terephthalamide microcapsules grafted with polyacrylic acid to enable pH responsiveness has been developed. Microcapsules were produced by… (more)

▼ A scalable method for the synthesis of polyethylene terephthalamide microcapsules grafted with polyacrylic acid to enable pH responsiveness has been developed. Microcapsules were produced by interfacial polymerisation of an oil-in-water emulsion in a 2 L batch reactor and subsequently circulated through an external loop reactor for UV irradiative surface grafting. Ungrafted microcapsule samples yielded 1.0 - 1.2 g desiccated capsules per experiment. Initial production trials were subject to severe agglomeration, observed during dialysis of the microcapsules with 30 % (v/v) ethanol solution. Lowering of the terephthaloyl dichloride monomer concentration, to 0.2 mol L⁻¹ in the chloroform / cyclohexane (3 : 1) organic solution, alleviated this unwanted agglomeration. Laser diffraction particle size analysis revealed microcapsules were produced with a 51 µm average diameter. A purpose built external loop irradiation reactor was used to facilitate graft polymerisation of acrylic acid on the microcapsules, using 254 nm UV light at 19 mW cm⁻². Characterisation of the external loop flow regime showed a mild deviation from ideal plug flow, with a vessel dispersion number of 0.014 and a Reynolds number of 1310. Confirmation of monomer polymerisation was ascertained by back titration and Fourier transform infrared spectroscopy. No distinction between homopolymer and grafted polyacrylic acid could be made by these characterisation methods. A Taguchi analysis on variables influencing grafting revealed high temperature to contribute most significantly to graft yield, followed by a long irradiation period. The development of a packed column pulse response method for testing pH response showed a high repeatability. However, release profile testing of a microcapsule slurry with an observed graft yield of 1.13 mmol g⁻¹ did not provide a definitive pH-based release of mPEG 5000 or PEGylated TAMRA dye. Determination of acrylic acid polymerisation kinetics following UV irradiation of the microcapsules is required for future optimisation of a functional graft yield.

Subjects/Keywords: drug delivery; microcapsules; pH responsive polymer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kelton, W. J. (2008). A scalable method for the production of pH responsive polyamide microcapsules for drug delivery. (Masters Thesis). University of Canterbury. Retrieved from http://dx.doi.org/10.26021/2160

Chicago Manual of Style (16^th Edition):

Kelton, William James. “A scalable method for the production of pH responsive polyamide microcapsules for drug delivery.” 2008. Masters Thesis, University of Canterbury. Accessed January 16, 2021. http://dx.doi.org/10.26021/2160.

MLA Handbook (7^th Edition):

Kelton, William James. “A scalable method for the production of pH responsive polyamide microcapsules for drug delivery.” 2008. Web. 16 Jan 2021.

Vancouver:

Kelton WJ. A scalable method for the production of pH responsive polyamide microcapsules for drug delivery. [Internet] [Masters thesis]. University of Canterbury; 2008. [cited 2021 Jan 16]. Available from: http://dx.doi.org/10.26021/2160.

Council of Science Editors:

Kelton WJ. A scalable method for the production of pH responsive polyamide microcapsules for drug delivery. [Masters Thesis]. University of Canterbury; 2008. Available from: http://dx.doi.org/10.26021/2160

University of Texas – Austin

29. Snelling, Diana Kathryn. Biodegradable microdevices for biological detection and smart therapy.

Degree: PhD, Chemical Engineering, 2010, University of Texas – Austin

URL: http://hdl.handle.net/2152/ETD-UT-2010-05-741

► Biodegradable, pH-responsive hydrogel networks composed of poly(methacrylic acid) crosslinked with varying mol percentages of polycaprolactone diacrylate were synthesized. These materials were characterized using NMR and… (more)

▼ Biodegradable, pH-responsive hydrogel networks composed of poly(methacrylic acid) crosslinked with varying mol percentages of polycaprolactone diacrylate were synthesized. These materials were characterized using NMR and FTIR. The equilibrium and dynamic swelling properties of these pH-responsive materials were studied. Also, the materials’ degradation was characterized using swelling studies and gel permeation chromatography. Methods were developed to incorporate these novel hydrogels as sensing components in silicon-based microsensors. Extremely thin layers of hydrogels were prepared by photopolymerizion atop silicon microcantilever arrays that served to transduce the pH-responsive volume change of the material into an optical signal. Organosilane chemistry allowed covalent adhesion of the hydrogel to the silicon beam. As the hydrogel swelled, the stress generated at the surface between the hydrogel and the silicon caused a beam deflection downward. The resulting sensor demonstrated a maximum sensitivity of 1nm/4.5E-5 pH unit. Sensors were tested in protein-rich solutions to mimic biological conditions and found to retain their high sensitivity. The existing theory was evaluated and developed to predict deflection of these composite cantilever beams. Another type of hydrogel-based microsensor was fabricated utilizing porous silicon rugate filters as transducers. Porous silicon rugate filters are garnering increased attention as components of in vivo biosensors due to their ability for remote readout through tissue. Here, the biodegradable, pH-responsive hydrogel was polymerized within the pores of a porous silicon rugate filter to generate a novel, completely degradable sensor. Silicon was electrochemically etched in hydrofluoric acid to generate the porous silicon rugate filter with its reflectance peak in the near infrared region. Poly(methacrylic acid) crosslinked with polycaprolactone diacrylate was polymerized within the pores using UV free radical photopolymerization. The reflectance peak of this sensor varied linearly with pH in the region pH 2.2 to 8.8. This work shows promise towards utilizing porous silicon rugate filters as transducers for environmentally responsive hydrogels for biosensing applications. Advisors/Committee Members: Peppas, Nicholas A., 1948- (advisor), Paul, Donald R. (committee member), Maynard, Jennifer (committee member), Sanchez, Isaac C. (committee member), Zaman, Muhammad (committee member).

Subjects/Keywords: Hydrogel; pH-responsive hydrogel; Microsensors; Microcantilever

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Snelling, D. K. (2010). Biodegradable microdevices for biological detection and smart therapy. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/ETD-UT-2010-05-741

Chicago Manual of Style (16^th Edition):

Snelling, Diana Kathryn. “Biodegradable microdevices for biological detection and smart therapy.” 2010. Doctoral Dissertation, University of Texas – Austin. Accessed January 16, 2021. http://hdl.handle.net/2152/ETD-UT-2010-05-741.

MLA Handbook (7^th Edition):

Snelling, Diana Kathryn. “Biodegradable microdevices for biological detection and smart therapy.” 2010. Web. 16 Jan 2021.

Vancouver:

Snelling DK. Biodegradable microdevices for biological detection and smart therapy. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2010. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/2152/ETD-UT-2010-05-741.

Council of Science Editors:

Snelling DK. Biodegradable microdevices for biological detection and smart therapy. [Doctoral Dissertation]. University of Texas – Austin; 2010. Available from: http://hdl.handle.net/2152/ETD-UT-2010-05-741

30. CHOOI KAR WAI. Stimuli sensitive core-shell nanoparticles for targetted drug delivery.

Degree: 2003, National University of Singapore

URL: https://scholarbank.nus.edu.sg/handle/10635/27660

Subjects/Keywords: Poly(N-isopropylacrylamide); Core-shell nanoparticles; Thermally-responsive; pH-responsive; Cyclosporin A; Indomethacin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

WAI, C. K. (2003). Stimuli sensitive core-shell nanoparticles for targetted drug delivery. (Thesis). National University of Singapore. Retrieved from https://scholarbank.nus.edu.sg/handle/10635/27660

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

WAI, CHOOI KAR. “Stimuli sensitive core-shell nanoparticles for targetted drug delivery.” 2003. Thesis, National University of Singapore. Accessed January 16, 2021. https://scholarbank.nus.edu.sg/handle/10635/27660.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

WAI, CHOOI KAR. “Stimuli sensitive core-shell nanoparticles for targetted drug delivery.” 2003. Web. 16 Jan 2021.

Vancouver:

WAI CK. Stimuli sensitive core-shell nanoparticles for targetted drug delivery. [Internet] [Thesis]. National University of Singapore; 2003. [cited 2021 Jan 16]. Available from: https://scholarbank.nus.edu.sg/handle/10635/27660.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

WAI CK. Stimuli sensitive core-shell nanoparticles for targetted drug delivery. [Thesis]. National University of Singapore; 2003. Available from: https://scholarbank.nus.edu.sg/handle/10635/27660

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations