subject:(PET for Clinical Diagnosis AND Drug Discovery)

University of Michigan

1. Joshi, Aniket. Improved Quantitative Methods for Multiple Neuropharmacological Non-Invasive Brain PET Studies.

Degree: PhD, Biomedical Engineering, 2008, University of Michigan

URL: http://hdl.handle.net/2027.42/61729

► Positron emission tomography (PET) is a medical imaging modality offering a powerful tool for brain research by mapping of in vivo neuropharmacological functions such as… (more)

▼ Positron emission tomography (PET) is a medical imaging modality offering a powerful tool for brain research by mapping of in vivo neuropharmacological functions such as metabolism, enzyme activity, and neuroreceptor binding site density and occupancy. Quantification in brain-PET can be classified into: 1) accurate quantification of radiotracer distribution such that image values are proportional to the radiotracer concentration in tissue, and 2) accurate quantification of the pharmacological state of the system-of-interest. This thesis addresses both these aspects for functional neuroreceptor imaging studies of the living brain. Traditional brain PET studies have at least two primary limitations. First, they measure only a single neuropharmacological aspect in isolation, which is often insufficient for characterizing a neurological condition. Second, data acquisition is accompanied by the invasive arterial blood sampling for measuring the input function to the system-of-interest. The motivation for this thesis was to address both these limitations, which led to the development of quantitative methods for multiple neuropharmacological PET studies performed without blood sampling. One such experimental design investigated was a dual-measurement intervention study where the system-of-interest is perturbed with the intent of changing the subject’s pharmacological status and system parameters are estimated both pre- and post-intervention. Second was a dual-tracer study where two radiotracers targeting two different neuropharmacological systems were injected closely in time in the same study. A major challenge in analyzing multiple pharmacological PET studies is the statistical noise-induced bias and variance in the parameter estimates. Methods developed in this thesis reduced almost all the bias (>90%) in the intervention studies with a corresponding improvement in precision. Parameter estimates for dual-tracer studies were obtained with inter-subject regions-of-interest means within ±10% of those obtained from single-tracer scans without appreciable increase in variance. The thesis also addresses inter-scanner PET image variability, a major confound in multi-center studies used to investigate disease progression. Since various PET centers have scanners with different hardware and software, systematic differences exist in multi-center data. This thesis develops a framework to reduce the inter-scanner PET image variability before pooling multi-center data for analysis. The methods developed reduced variability in phantom scans from different sites by approximately 50%. Advisors/Committee Members: Fessler, Jeffrey A. (committee member), Koeppe, Robert A. (committee member), Clinthorne, Neal H. (committee member), Meyer, Charles R. (committee member), Noll, Douglas C. (committee member).

Subjects/Keywords: Positron Emission Tomography; PET Pharmacokinetics; PET Kinetic Modeling; Neuropharamacological Measurements Using PET; Neuroimaging; PET for Clinical Diagnosis and Drug Discovery; Radiology; Health Sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Joshi, A. (2008). Improved Quantitative Methods for Multiple Neuropharmacological Non-Invasive Brain PET Studies. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/61729

Chicago Manual of Style (16^th Edition):

Joshi, Aniket. “Improved Quantitative Methods for Multiple Neuropharmacological Non-Invasive Brain PET Studies.” 2008. Doctoral Dissertation, University of Michigan. Accessed January 15, 2021. http://hdl.handle.net/2027.42/61729.

MLA Handbook (7^th Edition):

Joshi, Aniket. “Improved Quantitative Methods for Multiple Neuropharmacological Non-Invasive Brain PET Studies.” 2008. Web. 15 Jan 2021.

Vancouver:

Joshi A. Improved Quantitative Methods for Multiple Neuropharmacological Non-Invasive Brain PET Studies. [Internet] [Doctoral dissertation]. University of Michigan; 2008. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2027.42/61729.

Council of Science Editors:

Joshi A. Improved Quantitative Methods for Multiple Neuropharmacological Non-Invasive Brain PET Studies. [Doctoral Dissertation]. University of Michigan; 2008. Available from: http://hdl.handle.net/2027.42/61729

University of Zambia

2. Siame, Mwiche. Determinants of plasmodium faiciparum Malari and Sulphadoxine Pyrimethamine Resistance Molecular markers in pregnant women of Nchelenge and Choma Districts, Zambia .

Degree: 2014, University of Zambia

URL: http://hdl.handle.net/123456789/3558

► Background: Malaria remains a major public health challenge globally. In Zambia it is responsible for over 40% hospital admissions. Pregnant women and children less than… (more)

▼ Background: Malaria remains a major public health challenge globally. In Zambia it is responsible for over 40% hospital admissions. Pregnant women and children less than 5 years old remain the most affected. There has been an up-scale of interventions to reduce the prevalence of malaria in pregnant women this includes; distribution of insecticide treated nets, indoor residual spraying and Intermittent Preventive Treatment in pregnancy (IPTp). However, malaria is still one of the leading causes of morbidity and mortality in pregnant women. Studies have shown that resistance to SP is associated with mutations in the dhfr and dhps gene of the Plasmodium falciparum parasite. There are few studies that have been done to determine the prevalence of malaria and associated factors including genetic mutations in parasites found in pregnant women in Zambia.Aim: To determine and compare the prevalence of malaria, drug resistance molecular markers and associated risk factors in pregnant women of Choma and Nchelenge districts. Methodology: This cross-sectional study was conducted in Nchelenge and Choma districts of Zambia in February-April 2013. Rural Health Centers were randomly selected in each district and a census survey carried out at each health center. A questionnaire was administered and malaria testing done using RDT and microscopy, with collection of a dried blood spot. A chelex extraction was done to extract parasite DNA from dried blood spots followed by nested PCR. Positive samples by PCR then underwent mutation specific enzyme restriction digestion. Results: The overall results were: 375 women were screened in Nchelenge and 145 were screened in Choma district. The median age of the women was 23. The prevalence of malaria was 22% (n=83) in Nchelenge and 0% in Choma. Multivariate analysis showed an association between malaria and the age. Women aged 30-34 years old (AOR: 0.40) were less likely to have malaria than those aged 15-19 years old. The prevalence of dhf mutations ranged from 6-95 % while that of dhps mutations was 14-97% respectively. Conclusion: This study showed a high prevalence of malaria in pregnant women of Nchelenge district and a high number of mutations in the dhfr and dhps genes than previously reported. The high malaria endemicity in the general population of this area may have contributed to the high prevalence of resistant parasites in pregnant women. This has been shown in other studies that in highly endemic areas resistant parasites tend to spread quickly. As SP is the only approved drug for IPTp in Zambia, it is important to assess any association between IPTp and the prevalence of these resistant parasites.

Subjects/Keywords: Malaria Diagnosis; Malaria-Drug Therapy

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APA (6^th Edition):

Siame, M. (2014). Determinants of plasmodium faiciparum Malari and Sulphadoxine Pyrimethamine Resistance Molecular markers in pregnant women of Nchelenge and Choma Districts, Zambia . (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/3558

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Siame, Mwiche. “Determinants of plasmodium faiciparum Malari and Sulphadoxine Pyrimethamine Resistance Molecular markers in pregnant women of Nchelenge and Choma Districts, Zambia .” 2014. Thesis, University of Zambia. Accessed January 15, 2021. http://hdl.handle.net/123456789/3558.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Siame, Mwiche. “Determinants of plasmodium faiciparum Malari and Sulphadoxine Pyrimethamine Resistance Molecular markers in pregnant women of Nchelenge and Choma Districts, Zambia .” 2014. Web. 15 Jan 2021.

Vancouver:

Siame M. Determinants of plasmodium faiciparum Malari and Sulphadoxine Pyrimethamine Resistance Molecular markers in pregnant women of Nchelenge and Choma Districts, Zambia . [Internet] [Thesis]. University of Zambia; 2014. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/123456789/3558.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Siame M. Determinants of plasmodium faiciparum Malari and Sulphadoxine Pyrimethamine Resistance Molecular markers in pregnant women of Nchelenge and Choma Districts, Zambia . [Thesis]. University of Zambia; 2014. Available from: http://hdl.handle.net/123456789/3558

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas Medical Center

3. Tsao, Ning. Design, Synthesis and Development of Transporter Targeting Agents for Image-guided Therapy and Drug Delivery.

Degree: PhD, 2013, Texas Medical Center

URL: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/350

► The purpose of this study was to design, synthesize and develop novel transporter targeting agents for image-guided therapy and drug delivery. Two novel agents,… (more)

Subjects/Keywords: glycopeptide; Imaging probe; PET imaging; SPECT imaging; guanine; theranostics; drug delivery system; Amino Acids, Peptides, and Proteins; Diagnosis; Heterocyclic Compounds; Medicinal Chemistry and Pharmaceutics; Medicine and Health Sciences; Nucleic Acids, Nucleotides, and Nucleosides; Other Analytical, Diagnostic and Therapeutic Techniques and Equipment; Pharmacology; Radiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tsao, N. (2013). Design, Synthesis and Development of Transporter Targeting Agents for Image-guided Therapy and Drug Delivery. (Doctoral Dissertation). Texas Medical Center. Retrieved from https://digitalcommons.library.tmc.edu/utgsbs_dissertations/350

Chicago Manual of Style (16^th Edition):

Tsao, Ning. “Design, Synthesis and Development of Transporter Targeting Agents for Image-guided Therapy and Drug Delivery.” 2013. Doctoral Dissertation, Texas Medical Center. Accessed January 15, 2021. https://digitalcommons.library.tmc.edu/utgsbs_dissertations/350.

MLA Handbook (7^th Edition):

Tsao, Ning. “Design, Synthesis and Development of Transporter Targeting Agents for Image-guided Therapy and Drug Delivery.” 2013. Web. 15 Jan 2021.

Vancouver:

Tsao N. Design, Synthesis and Development of Transporter Targeting Agents for Image-guided Therapy and Drug Delivery. [Internet] [Doctoral dissertation]. Texas Medical Center; 2013. [cited 2021 Jan 15]. Available from: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/350.

Council of Science Editors:

Tsao N. Design, Synthesis and Development of Transporter Targeting Agents for Image-guided Therapy and Drug Delivery. [Doctoral Dissertation]. Texas Medical Center; 2013. Available from: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/350

Universitat de Barcelona

4. Márquez Arrico, Julia E. Personality in patients with dual diagnosis: The influence of severe mental illness.

Degree: Departament de Psicologia Clínica i Psicobiologia, 2017, Universitat de Barcelona

URL: http://hdl.handle.net/10803/463036

► El concepto de Patología Dual (PD) hace referencia a la concurrencia de un Trastorno Mental (TM) y un Trastorno por Uso de Sustancias (TUS) en… (more)

▼ El concepto de Patología Dual (PD) hace referencia a la concurrencia de un Trastorno Mental (TM) y un Trastorno por Uso de Sustancias (TUS) en una misma persona. La prevalencia conjunta de estos dos diagnósticos es muy frecuente, siendo los tres TM severos comórbidos más prevalentes en pacientes con TUS la Esquizofrenia (SZ), el Trastorno Bipolar (TB) y el Trastorno Depresivo Mayor (TDM). La coexistencia del TUS y estos TMs conlleva una serie de características clínicas, de evolución y pronóstico, que dificultan la recuperación del paciente en ambos trastornos. Sin embargo, en la actualidad existe una necesidad evidente de realizar estudios que aporten tanto conocimiento teórico como trasladable al manejo clínico de los pacientes con PD. El presente trabajo se propuso, como primer objetivo, estudiar las características de personalidad en una muestra de pacientes con TUS atendiendo al diagnóstico de TM severo comórbido. Evaluamos una muestra de 104 pacientes hombres en tratamiento para el TUS, considerados en tres grupos según el diagnóstico de TM severo comórbido: Grupo SZ+ (TUS y SZ; N=37), Grupo TB+ (TUS y TB; N=32) y Grupo TDM+ (TUS y TDM; N=35). Se utilizaron dos instrumentos de medición de la personalidad, el Temperament and Character Inventory-Revised (TCI-R) de Cloninger y el Zuckerman-Kuhlman Personality Questionnarie (ZKPQ), ambos basados en modelos psicobiológicos. Además, se exploró la influencia del TM en la relación entre personalidad y variables clínicas tanto del TUS como del TM. Nuestro segundo objetivo consistió en explorar la influencia de la PD en las estrategias de afrontamiento utilizadas en relación al tratamiento de la adicción. El tratamiento para el TUS representa un desafío para todos los pacientes, pero dadas las complicaciones clínicas de la PD se estudió el posible perfil diferencial de las estrategias de afrontamiento entre pacientes con SZ+ (diagnóstico más prevalente en nuestra muestra) y con sólo TUS. Para elucidar la influencia de la comorbilidad, se incluyó una muestra de 89 pacientes hombres en tratamiento para la adicción considerados en dos grupos: Grupo SZ+ (TUS y SZ; N=39) y Grupo TUS (N=43), a quienes se les aplicó el Coping Strategies Inventory (CSI) de Tobin junto con una exhaustiva evaluación clínica. Los principales resultados sobre personalidad indican que los pacientes con SZ+ destacan por una mayor ansiedad y temor a la incertidumbre (elevada Evitación del Riesgo del TCI-R), dificultad para perseverar ante la frustración y la fatiga (menor Persistencia del TCI-R) y preferencia por actividades en solitario o en grupos pequeños (menor Sociabilidad del ZKPQ). Nuestros hallazgos sugieren que los pacientes con SZ+ son quienes necesitarían especialmente de estrategias de manejo de expectativas negativas y ansiedad, de estrategias motivacionales y, siempre que sea posible, una incorporación paulatina a las sesiones grupales utilizadas durante el tratamiento para el TUS. Respecto a las características de personalidad de los pacientes con TB+, éstos destacan por la… Advisors/Committee Members: [email protected] (authoremail), false (authoremailshow), Adan Puig, Ana (director), Adan Puig, Ana (tutor), true (authorsendemail).

Subjects/Keywords: Psicologia clínica; Psicología clínica; Clinical psychology; Personalitat; Personalidad; Personality; Drogoaddicció; Drogadicción; Drug addiction; Psicopatologia; Psicopatología; Pathological psychology; Diagnòstic dual; Patología dual; Dual diagnosis; Ciències de la Salut; 616.89

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Márquez Arrico, J. E. (2017). Personality in patients with dual diagnosis: The influence of severe mental illness. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/463036

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Márquez Arrico, Julia E. “Personality in patients with dual diagnosis: The influence of severe mental illness.” 2017. Thesis, Universitat de Barcelona. Accessed January 15, 2021. http://hdl.handle.net/10803/463036.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Márquez Arrico, Julia E. “Personality in patients with dual diagnosis: The influence of severe mental illness.” 2017. Web. 15 Jan 2021.

Vancouver:

Márquez Arrico JE. Personality in patients with dual diagnosis: The influence of severe mental illness. [Internet] [Thesis]. Universitat de Barcelona; 2017. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10803/463036.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Márquez Arrico JE. Personality in patients with dual diagnosis: The influence of severe mental illness. [Thesis]. Universitat de Barcelona; 2017. Available from: http://hdl.handle.net/10803/463036

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

5. Gautério, Daiane Porto. Proposta de diagnósticos de enfermagem para idosos institucionalizados que fazem uso de medicamentos.

Degree: 2011, Universidade Federal do Rio Grande

URL: http://repositorio.furg.br/handle/1/3049

►

Dissertação(mestrado)- Universidade Federal do Rio Grande, Programa de Pós-Graduação em Enfermagem, Escola de Enfermagem, 2011.

O objetivo geral do estudo foi propor diagnósticos de enfermagem… (more)

▼

Dissertação(mestrado)- Universidade Federal do Rio Grande, Programa de Pós-Graduação em Enfermagem, Escola de Enfermagem, 2011.

O objetivo geral do estudo foi propor diagnósticos de enfermagem direcionados a idosos institucionalizados, a partir de características definidoras, referentes às possíveis reações adversas e interações dos medicamentos utilizados. Os objetivos específicos foram: identificar perfil dos idosos institucionalizados, tendo como foco a utilização de medicamentos e possíveis reações adversas e interações, relacionando-os a títulos de diagnósticos de enfermagem da North American Nursing Diagnoses Association; indicar diagnósticos de enfermagem que representem contribuição para o cuidado de enfermagem em uma instituição de longa permanência para idosos; confirmar, junto com enfermeiros, assistenciais/docentes, experts, os diagnósticos de enfermagem, a fim de que façam parte da proposta de cuidados de enfermagem para idosos institucionalizados. Trata-se de estudo exploratório, descritivo, com abordagem quantitativa, efetuado em duas etapas. Na primeira, foram utilizados dados de um banco originado da pesquisa “Perfil de idosos residentes numa Instituição de Longa Permanência para Idosos (ILPIs): proposta de ação de enfermagem/saúde”, quando foram selecionados 39 idosos que faziam uso de medicação. Nessa etapa, foi realizada a identificação do perfil dos institucionalizados, tendo como foco a utilização de medicamentos. A partir de características definidoras manifestadas pelos idosos, foram estabelecidos os títulos de diagnósticos de enfermagem, considerando-se o processo de raciocínio diagnóstico de Risner e a Classificação da North American Nursing Diagnoses Association. Na segunda etapa da pesquisa, foi alcançada a confirmação dos diagnósticos de enfermagem estabelecidos, por enfermeiros experts, através da técnica Delphi de validação de conteúdo. Os achados referentes ao perfil dos idosos evidenciaram maior número de mulheres; idade entre 80-89 anos; a maioria sabe ler e constitui-se de viúvas. As doenças do aparelho circulatório são as mais frequentes. Os idosos usam em média 3,7 medicamentos e 30,8% deles utilizam polifarmácia. Os medicamentos mais usados foram para as intercorrências do sistema cardiovascular. Verificou-se a presença de medicamentos considerados impróprios para idosos. Foram identificados 11 diagnósticos de enfermagem, enviados para a confirmação por experts; desses, sete atingiram 70% ou mais de concordância. São eles: Risco de quedas, Eliminação urinária prejudicada, Constipação, Memória prejudicada, Intolerância à atividade, Perambulação e Fadiga. Os diagnósticos obtidos, integraram junto com as prescrições de enfermagem, uma proposta de cuidados de enfermagem ao idoso institucionalizado que faz uso de medicamentos. Os idosos institucionalizados e utilizam medicamentos podem apresentar maior fragilidade; por isso, a identificação de diagnósticos permite um melhor direcionamento do cuidado de enfermagem, por possibilitar reconhecimento prévio das necessidades manifestadas…

Advisors/Committee Members: Santos, Silvana Sidney Costa.

Subjects/Keywords: Enfermagem; Diagnóstico de enfermagem; Idoso; Uso de medicamentos; Instituição de longa permanência para idosos; Nursing; Nursing diagnosis; Aged; Drug utilization; Homes for the aged; Enfermería; Diagnóstico de enfermería; Anciano; Utilizatión de medicamentos; Hogares para ancianos

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gautério, D. P. (2011). Proposta de diagnósticos de enfermagem para idosos institucionalizados que fazem uso de medicamentos. (Masters Thesis). Universidade Federal do Rio Grande. Retrieved from http://repositorio.furg.br/handle/1/3049

Chicago Manual of Style (16^th Edition):

Gautério, Daiane Porto. “Proposta de diagnósticos de enfermagem para idosos institucionalizados que fazem uso de medicamentos.” 2011. Masters Thesis, Universidade Federal do Rio Grande. Accessed January 15, 2021. http://repositorio.furg.br/handle/1/3049.

MLA Handbook (7^th Edition):

Gautério, Daiane Porto. “Proposta de diagnósticos de enfermagem para idosos institucionalizados que fazem uso de medicamentos.” 2011. Web. 15 Jan 2021.

Vancouver:

Gautério DP. Proposta de diagnósticos de enfermagem para idosos institucionalizados que fazem uso de medicamentos. [Internet] [Masters thesis]. Universidade Federal do Rio Grande; 2011. [cited 2021 Jan 15]. Available from: http://repositorio.furg.br/handle/1/3049.

Council of Science Editors:

Gautério DP. Proposta de diagnósticos de enfermagem para idosos institucionalizados que fazem uso de medicamentos. [Masters Thesis]. Universidade Federal do Rio Grande; 2011. Available from: http://repositorio.furg.br/handle/1/3049

Addis Ababa University

6. Wegene, Tamene. ASSESSMENT OF BLOOD AGAR MEDIA FOR THE DIAGNOSIS OF TUBERCULOSIS .

Degree: 2012, Addis Ababa University

URL: http://etd.aau.edu.et/dspace/handle/123456789/390

► Diagnosing tuberculosis is a challenge because of the complex nature of the bacteria. Recently, the need for TB culture is growing due to the increasing… (more)

▼ Diagnosing tuberculosis is a challenge because of the complex nature of the bacteria. Recently, the need for TB culture is growing due to the increasing demand for TB drug susceptibility testing(DST) and due to the high incidence of TB/HIV co-infection, which faces a great deal of misdiagnosis. Even though there are a number of better culture technology systems, most of these technologies are not feasible and affordable for resource limited countries like Ethiopia. Therefore, resource limited countries mainly rely on available solid culture system for Mycobacterium isolation and DST despite the fact, they are time consuming, costly and need stringent media preparation procedure. Thus, this study was aimed to assess the performance of 5% sheep blood agar media for the isolation and DST of M. tuberculosis complex. Blood agar is simple to prepare, readily available, and cheap media. 107 clinical specimens were collected from patients referred to EHNRI for TB culture. Specimens were liquefied and decontaminated by N-acetyl L- cysteine sodium hydroxide method and cultured on Lowenstein-Jensen media, blood agar media and BACTEC MGIT 960 system. Species identification was done using Capilla TB-Neo (TAUNS Laboratories Inc, Numazu, Japan). DST for M. tuberculosis complex isolates were performed using proportion method on LJ and blood agar media. From the total 107 specimens cultured, 2 specimens with persistent contamination were excluded from analysis, and analyses were done with the remaining 105 specimens. The sensitivity, specificity, PPV and NPV of blood agar media was 98, 98.2, 98 and 98.2%, respectively, as compared to LJ media, whereas the sensitivity, specificity, positive predictive value and negative predictive value of blood agar media were 87.2, 100, 100 and 87.2% respectively, when compared to MGIT. Mean time for culture positivity was 9.3, 17.3 and 22.7 days for MGIT, blood agar and LJ media, respectively and the difference was statistically significant (P< 0.0001). On the other hand, concordance between blood agar media and LJ media for DST was, 97.7% for Isonizid, 100% for rifampin, 90.7% for streptomycin and 97.7% for etambutol. The contamination rate was 5.1, 9.7 and 14.8% for blood agar media, LJ media and MGIT, respectively. In conclusion, blood agar media was correlated well with LJ media both for the isolation and drug susceptibility testing of M.TB and it was faster than LJ media. Advisors/Committee Members: Kifle Dagne(Dr.) (advisor).

Subjects/Keywords: Blood agar media; Diagnosis; Drug susceptibility testing; Isolation; Tuberculosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wegene, T. (2012). ASSESSMENT OF BLOOD AGAR MEDIA FOR THE DIAGNOSIS OF TUBERCULOSIS . (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/390

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wegene, Tamene. “ASSESSMENT OF BLOOD AGAR MEDIA FOR THE DIAGNOSIS OF TUBERCULOSIS .” 2012. Thesis, Addis Ababa University. Accessed January 15, 2021. http://etd.aau.edu.et/dspace/handle/123456789/390.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wegene, Tamene. “ASSESSMENT OF BLOOD AGAR MEDIA FOR THE DIAGNOSIS OF TUBERCULOSIS .” 2012. Web. 15 Jan 2021.

Vancouver:

Wegene T. ASSESSMENT OF BLOOD AGAR MEDIA FOR THE DIAGNOSIS OF TUBERCULOSIS . [Internet] [Thesis]. Addis Ababa University; 2012. [cited 2021 Jan 15]. Available from: http://etd.aau.edu.et/dspace/handle/123456789/390.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wegene T. ASSESSMENT OF BLOOD AGAR MEDIA FOR THE DIAGNOSIS OF TUBERCULOSIS . [Thesis]. Addis Ababa University; 2012. Available from: http://etd.aau.edu.et/dspace/handle/123456789/390

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Ghana

7. Eboreime, O. Factors Associated With The Utilization Of Genexpert In The Diagnosis Of Drug Resistant Tuberculosis In The Greater Accra Region.

Degree: 2017, University of Ghana

URL: http://ugspace.ug.edu.gh/handle/123456789/23772

► Background There has been a gap in the diagnosis of drug resistant tuberculosis, hence a new rapid diagnostic test; the geneXpert was introduced by the… (more)

▼ Background There has been a gap in the diagnosis of drug resistant tuberculosis, hence a new rapid diagnostic test; the geneXpert was introduced by the World Health Organization in 2010. The objective of this study was to identify factors that affect the utilization of the geneXpert intervention in the Greater Accra Region. Methods This was a mixed methods study. A qualitative approach was used to provide empirical explanations for the findings of the quantitative component which was cross-sectional. Functional facilities administering geneXpert were enrolled into the study. Quantitative data on risk factors for drug-resistant tuberculosis and geneXpert testing were obtained from the tuberculosis registers on 386 cases of tuberculosis using a pre-tested data extraction tool. Ten health care workers were interviewed using a semi-structured in-depth interview guide. Quantitative and qualitative results were triangulated in line with study objectives. Results A total of 386 cases of tuberculosis were included in the study. Less than half of the total cases reviewed 89(23%) had a geneXpert test. The proportion of cases at risk of drug resistant tuberculosis who were tested with geneXpert was relatively low among the various risk categories. Risk factors for drug resistant tuberculosis had no influence on having a geneXpert test and cases of extra-pulmonary tuberculosis were less likely to have a geneXpert test compared to cases of pulmonary tuberculosis [AOR= 0.17 (95%CI = 0.06-0.51), p< 0.002]. In-depth interviews identified lack of skilled technicians to collect extra-pulmonary specimens, sputum collection in children, loss to follow up for testing, an inefficient test result communication system and cartridge supply management system, lack of refrigerators for temporary storage of specimen and equipment maintenance as factors affecting the utilization of geneXpert. Conclusion This study found the non-prioritization of patients at risk of drug resistant tuberculosis for geneXpert testing resulting from lack of adherence to standard guidelines a key factor affecting the utilization of geneXpert. Based on findings, making geneXpert guidelines available at health facilities as well as training of health workers on the guidelines is recommended to improve the uptake of geneXpert.

Subjects/Keywords: Utilization; Genexpert; Diagnosis; Drug; Tuberculosis; The Greater Accra Region

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APA (6^th Edition):

Eboreime, O. (2017). Factors Associated With The Utilization Of Genexpert In The Diagnosis Of Drug Resistant Tuberculosis In The Greater Accra Region. (Masters Thesis). University of Ghana. Retrieved from http://ugspace.ug.edu.gh/handle/123456789/23772

Chicago Manual of Style (16^th Edition):

Eboreime, O. “Factors Associated With The Utilization Of Genexpert In The Diagnosis Of Drug Resistant Tuberculosis In The Greater Accra Region. ” 2017. Masters Thesis, University of Ghana. Accessed January 15, 2021. http://ugspace.ug.edu.gh/handle/123456789/23772.

MLA Handbook (7^th Edition):

Eboreime, O. “Factors Associated With The Utilization Of Genexpert In The Diagnosis Of Drug Resistant Tuberculosis In The Greater Accra Region. ” 2017. Web. 15 Jan 2021.

Vancouver:

Eboreime O. Factors Associated With The Utilization Of Genexpert In The Diagnosis Of Drug Resistant Tuberculosis In The Greater Accra Region. [Internet] [Masters thesis]. University of Ghana; 2017. [cited 2021 Jan 15]. Available from: http://ugspace.ug.edu.gh/handle/123456789/23772.

Council of Science Editors:

Eboreime O. Factors Associated With The Utilization Of Genexpert In The Diagnosis Of Drug Resistant Tuberculosis In The Greater Accra Region. [Masters Thesis]. University of Ghana; 2017. Available from: http://ugspace.ug.edu.gh/handle/123456789/23772

University of Manchester

8. Morton, William John Richard. The diagnosis and epidemiology of hepatitis C infection in Greater Manchester.

Degree: 2018, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:314314

► Background: The burden of disease from Hepatitis C virus (HCV) remains a national public health priority in England. Guidance and policy recommend targeted testing of… (more)

▼ Background: The burden of disease from Hepatitis C virus (HCV) remains a national public health priority in England. Guidance and policy recommend targeted testing of high-risk groups. Fragmented laboratory information systems mean that it is not possible to measure progress against this goal. This thesis aimed to investigate testing activity and the epidemiology of HCV infection in Greater Manchester GM). This thesis also aimed to assess the feasibility increasing the GP knowledge of HCV using an electronic awareness raising intervention. Methods: This study created the first individual-level testing dataset covering the entire population of a large conurbation, linking testing data collected from six laboratories. Descriptive statistics were used to calculate activity and positivity rates by time, person and setting of test. Using logistic regression odds ratios were calculated to explore differences between individuals tested and positivity rates between settings and method of test. A feasibility study was used to investigate knowledge of HCV in GPs in Practices in Manchester (n=8) pre- and post-awareness raising intervention. Results: Between 2008 and 2012 163,729 individuals were tested for HCV antibodies (anti-HCV) in 2,742 different locations across GM; 8,659 individuals (5.3%) tested anti-HCV positive. Males were 79% more likely to be anti-HCV positive than females. 39.4% of individuals tested in specialist drug services were anti-HCV positive and were 11 times more likely to be anti-HCV positive than individuals tested in General Practice. Total annual testing activity increased by 37% between 2008 and 2012. The highest positivity rates were observed in specialist drug services (40-44% annual rates). 20,443 individuals (12.5% of population) were tested on more than 1 occasion with 30,445(15.7%) â€˜repeat testingâ€™ costing in excess of Â£200,000. The positivity rate in individuals only tested using Dried Blood Spot Testing (DBST) was almost twice the rate observed in individuals tested using either method, with 66% and 39.4%. Individuals tested only using DBST were more than three times more likely to be anti-HCV positive than those tested using either method. In the GP study, overall, testing activity increased in intervention Practices by 8.67% in the 12 months post-intervention compared to the previous 12 months; accompanied by an increase in positivity rate from 5.5% at baseline to 11.4% post-intervention. Conclusions: It proved possible to quantify the demographic and behavioural characteristics of all individuals tested in a population of 2.6 million residents between 2008 and 2012. To my knowledge, this is the first study published to adopt this approach to surveillance of anti-HCV testing. This unique study has demonstrated the value of using validated methodology for local and regional level surveillance of anti-HCV testing. GM testing activity, positivity rates and HCV epidemiology were all found to differ from those observed at national level. The approach used in the GP study identified issues… Advisors/Committee Members: MILLAR, TIM TW, AGIUS, RAYMOND R, Verma, Arpana, Millar, Tim, Agius, Raymond.

Subjects/Keywords: hepatitis C virus; epidemiology; diagnosis; surveillance; injecting drug user; migrant health

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Morton, W. J. R. (2018). The diagnosis and epidemiology of hepatitis C infection in Greater Manchester. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:314314

Chicago Manual of Style (16^th Edition):

Morton, William John Richard. “The diagnosis and epidemiology of hepatitis C infection in Greater Manchester.” 2018. Doctoral Dissertation, University of Manchester. Accessed January 15, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:314314.

MLA Handbook (7^th Edition):

Morton, William John Richard. “The diagnosis and epidemiology of hepatitis C infection in Greater Manchester.” 2018. Web. 15 Jan 2021.

Vancouver:

Morton WJR. The diagnosis and epidemiology of hepatitis C infection in Greater Manchester. [Internet] [Doctoral dissertation]. University of Manchester; 2018. [cited 2021 Jan 15]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:314314.

Council of Science Editors:

Morton WJR. The diagnosis and epidemiology of hepatitis C infection in Greater Manchester. [Doctoral Dissertation]. University of Manchester; 2018. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:314314

Stellenbosch University

9. Mlamla, Zandile Cleopatra. Improving methods for genotypic drug resistance testing in Mycobacterium tuberculosis.

Degree: MScMedSc, Biomedical Science, 2011, Stellenbosch University

URL: http://hdl.handle.net/10019.1/6756

► ENGLISH ABSTRACT: An important next step to Tuberculosis control relies on the translation of basic science and modern diagnostic techniques into primary health care clinics.… (more)

▼ ENGLISH ABSTRACT: An important next step to Tuberculosis control relies on the translation of basic science and modern diagnostic techniques into primary health care clinics. These assays must be rapid, inexpensive, interpretation of results must be easy and they must be simple so that a healthcare worker with limited training can perform the tests under safe conditions. This study consists of four aims. The first aim was to develop a methodology to sterilize sputum specimens for rapid TB diagnosis and drug resistance testing. Candidate bactericides were identified from the literature, and tested for their bactericidal activity in Mycobacterium tuberculosis. We identified ultraseptin®aktiv as a powerful bactericidal agent which sterilizes sputum specimens for subsequent safe handling prior to light emitting diode microscopy and it also provides a DNA template for PCR-based tests. An algorithm has been proposed for the processing of specimens and rapid diagnosis of TB and drug resistant TB while patients wait for results. Recently, the World Health Organization has endorsed the MTBDRplus test for diagnosis of TB and drug resistant TB. However genotypic tests may have more problems than anticipated. With the HIV pandemic, an increase of non-tuberculous mycobacteria has been reported. The sensitivity of genotypic tests in specimens with underlying non-tuberculous mycobacterial species therefore requires further evaluation. This study therefore also aimed at determining the reliability of the MTBDRplus assay for detection of drug resistant TB where non-tuberculous bacterial load is high. Clinically relevant non-tuberculous mycobacterium DNA and DNA from a multi-drug resistant TB isolate were obtained. Ratios of the different NTM with the MDR-TB DNA were made and subjected to the MTBDRplus assay. Known mix NTM and TB infected clinical isolates and sputum sediments were also evaluated for TB and drug resistance detection on the MTBDRplus assay. Under these conditions, this study provides evidence that the MTBDRplus test cannot reliably detect TB and drug resistance TB in specimens with underlying non-tuberculous mycobacteria. Thirdly, to evaluate the sensitivity of the MTBDRplus assay for detecting drug resistance in hetero-resistant isolates, ratios were made using purified DNA from an MDR and pan-susceptible TB isolate. The MTBDRplus assay was then performed on the different ratios. We report that the MTBDRplus assay can efficiently detect wild type DNA in genes associated with resistance during the early evolution of drug resistance. However, in the later stage during treatment when both the wild type and mutants are present, the detection limit for the mutant DNA was 1:55. Due to these results, the MTBDRplus assay should still be further improved or other tests should be developed to address these limitations. And finally to combat cross amplicon contamination during the final steps of genotypic detection with the MTBDRplus assay, a proof of concept for a patentable closed tube line probe device was proposed on the… Advisors/Committee Members: Victor, Thomas C., Warren, Robin M., Louw, Gail E., University of Stellenbosch. Faculty of Health Sciences. Dept. of Biomedical Science. Molecular Biology and Human Genetics..

Subjects/Keywords: Medical biochemistry; Dissertations – Medical biochemistry; Drug resistance in microorganisms – Testing; Mycobacterium tuberculosis – Diagnosis; Diagnosis, Noninvasive; Medical Biochemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mlamla, Z. C. (2011). Improving methods for genotypic drug resistance testing in Mycobacterium tuberculosis. (Masters Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/6756

Chicago Manual of Style (16^th Edition):

Mlamla, Zandile Cleopatra. “Improving methods for genotypic drug resistance testing in Mycobacterium tuberculosis.” 2011. Masters Thesis, Stellenbosch University. Accessed January 15, 2021. http://hdl.handle.net/10019.1/6756.

MLA Handbook (7^th Edition):

Mlamla, Zandile Cleopatra. “Improving methods for genotypic drug resistance testing in Mycobacterium tuberculosis.” 2011. Web. 15 Jan 2021.

Vancouver:

Mlamla ZC. Improving methods for genotypic drug resistance testing in Mycobacterium tuberculosis. [Internet] [Masters thesis]. Stellenbosch University; 2011. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10019.1/6756.

Council of Science Editors:

Mlamla ZC. Improving methods for genotypic drug resistance testing in Mycobacterium tuberculosis. [Masters Thesis]. Stellenbosch University; 2011. Available from: http://hdl.handle.net/10019.1/6756

McMaster University

10. Knight, Spencer D. The Synthesis of Dendrimer-based Radioimaging Agents.

Degree: MSc, 2012, McMaster University

URL: http://hdl.handle.net/11375/12441

►

The synthesis of new macromolecular diagnostic imaging agents has been a growing field in polymeric chemistry research. Dendrimers provide a viable scaffold for such… (more)

Subjects/Keywords: dendrimer; radioimaging; therapeutics; epr effect; drug delivery; polymer chemistry; Diagnosis; Organic Chemistry; Polymer Chemistry; Radiochemistry; Diagnosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Knight, S. D. (2012). The Synthesis of Dendrimer-based Radioimaging Agents. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/12441

Chicago Manual of Style (16^th Edition):

Knight, Spencer D. “The Synthesis of Dendrimer-based Radioimaging Agents.” 2012. Masters Thesis, McMaster University. Accessed January 15, 2021. http://hdl.handle.net/11375/12441.

MLA Handbook (7^th Edition):

Knight, Spencer D. “The Synthesis of Dendrimer-based Radioimaging Agents.” 2012. Web. 15 Jan 2021.

Vancouver:

Knight SD. The Synthesis of Dendrimer-based Radioimaging Agents. [Internet] [Masters thesis]. McMaster University; 2012. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/11375/12441.

Council of Science Editors:

Knight SD. The Synthesis of Dendrimer-based Radioimaging Agents. [Masters Thesis]. McMaster University; 2012. Available from: http://hdl.handle.net/11375/12441

11. Haller, Moira. Disentangling the Directions of Influence among Trauma Exposure, Posttraumatic Stress Disorder Symptoms, and Alcohol and Drug Problems.

Degree: PhD, Psychology, 2014, Arizona State University

URL: http://repository.asu.edu/items/15874

► The present study utilized longitudinal data from a high-risk community sample (n= 377; 166 trauma-exposed; 54% males; 52% children of alcoholics; 73% non-Hispanic/Latino Caucasian; 22%… (more)

▼ The present study utilized longitudinal data from a high-risk community sample (n= 377; 166 trauma-exposed; 54% males; 52% children of alcoholics; 73% non-Hispanic/Latino Caucasian; 22% Hispanic/Latino; 5% other ethnicity) to test a series of hypotheses that may help explain the risk pathways that link traumatic stress, posttraumatic stress disorder (PTSD) symptomatology, and problematic alcohol and drug use. Specifically, this study examined whether pre-trauma substance use problems increase risk for trauma exposure (the high-risk hypothesis) or PTSD symptoms (the susceptibility hypothesis), whether PTSD symptoms increase risk for later alcohol/drug problems (the self-medication hypothesis), and whether the association between PTSD symptoms and alcohol/drug problems is due to shared risk factors (the shared vulnerability hypothesis). This study also examined the roles of gender and ethnicity in these pathways. A series of logistic and negative binomial regressions were performed in a path analysis framework. A composite pre-trauma family adversity variable was formed from measures of family conflict, family life stress, parental alcoholism, and other parent psychopathology. Results provided the strongest support for the self-medication hypothesis, such that PTSD symptoms predicted higher levels of later alcohol and drug problems among non-Hispanic/Latino Caucasian participants, over and above the influences of pre-trauma family adversity, pre-trauma substance use problems, trauma exposure, and demographic variables. Results partially supported the high-risk hypothesis, such that adolescent substance use problems had a marginally significant unique effect on risk for assaultive violence exposure but not on overall risk for trauma exposure. There was no support for the susceptibility hypothesis, as pre-trauma adolescent substance use problems did not significantly influence risk for PTSD diagnosis/symptoms over and above the influence of pre-trauma family adversity. Finally, there was little support for the shared vulnerability hypothesis. Neither trauma exposure nor preexisting family adversity accounted for the link between PTSD symptoms and later substance use problems. These results add to a growing body of literature in support of the self-medication hypothesis. Findings extend previous research by showing that PTSD symptoms may influence the development of alcohol and drug problems over and above the influence of trauma exposure itself, preexisting family risk factors, and baseline levels of substance use.

Subjects/Keywords: Clinical psychology; Psychology; alcohol and drug problems; dual diagnosis; posttraumatic stress disorder; PTSD; self-medication; substance use disorders

…96 vii Page Adjusting Main Hypotheses for False Discovery Rate… …Statistics for Poisson, Negative Binomial, ZIP, and ZINB Models Predicting Alcohol and Drug… …Hypothesis: Results of Logistic Regression Predicting Risk for PTSD Diagnosis… …risk for alcohol and drug problems following traumatic stress. In order to better understand… …differentiate among risk factors for trauma exposure, PTSD, and problematic alcohol and drug use…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Haller, M. (2014). Disentangling the Directions of Influence among Trauma Exposure, Posttraumatic Stress Disorder Symptoms, and Alcohol and Drug Problems. (Doctoral Dissertation). Arizona State University. Retrieved from http://repository.asu.edu/items/15874

Chicago Manual of Style (16^th Edition):

Haller, Moira. “Disentangling the Directions of Influence among Trauma Exposure, Posttraumatic Stress Disorder Symptoms, and Alcohol and Drug Problems.” 2014. Doctoral Dissertation, Arizona State University. Accessed January 15, 2021. http://repository.asu.edu/items/15874.

MLA Handbook (7^th Edition):

Haller, Moira. “Disentangling the Directions of Influence among Trauma Exposure, Posttraumatic Stress Disorder Symptoms, and Alcohol and Drug Problems.” 2014. Web. 15 Jan 2021.

Vancouver:

Haller M. Disentangling the Directions of Influence among Trauma Exposure, Posttraumatic Stress Disorder Symptoms, and Alcohol and Drug Problems. [Internet] [Doctoral dissertation]. Arizona State University; 2014. [cited 2021 Jan 15]. Available from: http://repository.asu.edu/items/15874.

Council of Science Editors:

Haller M. Disentangling the Directions of Influence among Trauma Exposure, Posttraumatic Stress Disorder Symptoms, and Alcohol and Drug Problems. [Doctoral Dissertation]. Arizona State University; 2014. Available from: http://repository.asu.edu/items/15874

University of Western Ontario

12. Elzagallaai, Abdelbaset A. Predicting Drug Hypersensitivity Reactions: Mechanistic and Clinical Implications.

Degree: 2011, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/207

► Adverse drug reactions (ADRs) are responsible for a high number of morbidities and mortalities worldwide and estimated to be the fourth most important cause of… (more)

▼ Adverse drug reactions (ADRs) are responsible for a high number of morbidities and mortalities worldwide and estimated to be the fourth most important cause of death in the US and Canada after heart diseases, cancer and stroke. ADRs are either type A (~80%) which are predictable, related to the drug pharmacology and dose-dependent or type B (~20%), which are unpredictable, unrelated to the drug pharmacology and have no clear dose-dependency. Drug hypersensitivity reactions (DHRs) represent the majority of type-B ADRs, which are rare but potentially fatal and unpredictable. The latter aspect makes DHRs very difficult to diagnose and necessitate the development of a reliable and safe in vitro diagnostic test to aid prediction and confirm diagnosis. The currently used tests are not well characterized and their predictive value is unknown. The aim of this work was to evaluate the clinical value of the currently used diagnostic tests for DHRs; to develop a simple, reliable and safe test; and to explore the pathophysiology of DHRs using different approaches for further understanding of the DHRs pathophysiology which will allow us to develop new means for prevention prediction and diagnosis. Methodology used involved performing systematic literature reviews, population survey on previously tested patients, patient recruitment and laboratory techniques that include preparation and testing of liver microsomes from human and animal origin, using hematopoietic cell lines and primary cultures of different blood cell types as a surrogate model to explore DHRs pathphysiology and test patient susceptibility for DHRs. Systematic review of available literature revealed that the currently used diagnostic tools for DHRs lack any characterization or standardization and much more work is needed to further characterize and improve these tools. We developed a novel laboratory approach for diagnosis of DHRs that proved to be less cumbersome and potentially more reliable than other currently used tests. Using different biochemical and genetic methods, we introduced novel concepts that explain some aspects of the pathophysiology of DHRs. The main achievement in this research was the development of a novel diagnostic test for DHRs, the in vitro platelet toxicity assay (iPTA), which has a great potential as a clinical tool due to its simple procedure and good reproducibility. We hope that these features will allow its wider clinical use as oppose to other currently used tests. In addition, expanding our understanding of the molecular pathophysiology of DHRs using recent technical advances in genetic analysis and laboratory techniques will have a great impact on the management of these cases.

Subjects/Keywords: Adverse drug reaction; drug hypersensitivity; in vitro diagnosis; in vitro platelet toxicity assay; the lymphocyte toxicity assay; Medical Pharmacology; Medical Toxicology

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APA (6^th Edition):

Elzagallaai, A. A. (2011). Predicting Drug Hypersensitivity Reactions: Mechanistic and Clinical Implications. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/207

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Elzagallaai, Abdelbaset A. “Predicting Drug Hypersensitivity Reactions: Mechanistic and Clinical Implications.” 2011. Thesis, University of Western Ontario. Accessed January 15, 2021. https://ir.lib.uwo.ca/etd/207.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Elzagallaai, Abdelbaset A. “Predicting Drug Hypersensitivity Reactions: Mechanistic and Clinical Implications.” 2011. Web. 15 Jan 2021.

Vancouver:

Elzagallaai AA. Predicting Drug Hypersensitivity Reactions: Mechanistic and Clinical Implications. [Internet] [Thesis]. University of Western Ontario; 2011. [cited 2021 Jan 15]. Available from: https://ir.lib.uwo.ca/etd/207.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Elzagallaai AA. Predicting Drug Hypersensitivity Reactions: Mechanistic and Clinical Implications. [Thesis]. University of Western Ontario; 2011. Available from: https://ir.lib.uwo.ca/etd/207

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. Nguyen, Thi Ngoc Anh. Development of a DNA chip for rapid detection of first-line and second-line drug resistances in Mycobacterium tuberculosis : Développement d’une puce à ADN pour la détection rapide de la résistance aux médicaments de première et seconde ligne chez Mycobacterium tuberculosis.

Degree: Docteur es, Biologie Santé, 2018, Montpellier

URL: http://www.theses.fr/2018MONTT074

►

L’émergence et l’augmentation continue de la résistance aux médicaments chez Mycobacterium tuberculosis (MTB) constituent un défi majeur pour la lutte antituberculeuse. Pour résoudre le problème… (more)

▼

L’émergence et l’augmentation continue de la résistance aux médicaments chez Mycobacterium tuberculosis (MTB) constituent un défi majeur pour la lutte antituberculeuse. Pour résoudre le problème de temps (2 à 8 semaines) posé par les tests classiques de sensibilité aux médicaments (DST), des tests moléculaires ont été développés pour la détection précoce des mutations associées à la résistance. Jusqu'à présent, à l'exception du séquençage complet (incompatible avec un diagnostic de routine dans les pays en développement), aucun test ne détecte simultanément les différents types de résistance majeurs en une seule réaction. Sur la base de la littérature et de travaux antérieurs menés au Vietnam, au Laos et au Cambodge, une puce à ADN capable de détecter 184 mutations liées à la résistance aux médicaments de première et de deuxième lignes a été mise au point. En comparaison avec les données de DST, la puce a montré une sensibilité (84,3%-100%) et une spécificité élevées (89,2%-100%). Par rapport au séquençage, la puce a donné des résultats comparables, avec une sensibilité entre 90% et 100% et une spécificité entre 98,2% et 100%. Elle offre, de plus, une meilleure couverture que les tests moléculaires approuvés par l'OMS, car elle permet la détection des résistances aux médicaments de première et de deuxième lignes dans un seul test. Le temps de traitement des isolats issus de la culture est d’environ 6 à 7 heures, ce qui réduit considérablement le temps de diagnostic par rapport au DST. En conclusion, la puce à ADN a été développée avec succès. Certains aspects techniques doivent maintenant être améliorés pour en faire un outil de diagnostic abordable et facile à utiliser.

The emergence and continuous increase of drug resistance in Mycobacterium tuberculosis (MTB) is a major challenge for tuberculosis (TB) control. To overcome the time-consuming problem of conventional drug susceptibility testing (DST), many molecular-based tests have been recently developed for early detection of drug resistance-associated mutations. Up to now, except whole genome sequencing (not ready for routine diagnostic in low and middle-income countries), no test has the capacity to simultaneously detect the different types of drug resistance to first- and second-line drugs in one reaction. Based on the literature and previous works carried out in Vietnam, Laos and Cambodia, in this study, a DNA chip was developed able to detect 184 main mutations conferring resistance to both first- and second-line drugs. Compared to DST, the DNA chip showed high sensitivity (between 84.3% and 100%) and high specificity (between 89.2% and 100%). Compared to sequencing, the DNA chip showed comparable accuracy, with sensitivity between 90% and 100% and specificity between 98.2% and 100%. The DNA chip showed a better coverage than the WHO endorsed molecular tests since it enables the detection of both first- and second-line drug resistances in one test. The turn-around time is about 6-7h from cultured isolates reducing considerably the diagnostic time compared…

Advisors/Committee Members: Bañuls, Anne-Laure (thesis director), Nguyen, Thi Van Anh (thesis director).

Subjects/Keywords: Puce à ADN; Mycobactéries tuberculeuses; Mutation; Diagnostic; Multirésistance; Ultrarésistance; DNA microarray; Mycobacterium tuberculosis; Mutation; Diagnosis; Multi-Drug resistance; Extensively drug resistance

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nguyen, T. N. A. (2018). Development of a DNA chip for rapid detection of first-line and second-line drug resistances in Mycobacterium tuberculosis : Développement d’une puce à ADN pour la détection rapide de la résistance aux médicaments de première et seconde ligne chez Mycobacterium tuberculosis. (Doctoral Dissertation). Montpellier. Retrieved from http://www.theses.fr/2018MONTT074

Chicago Manual of Style (16^th Edition):

Nguyen, Thi Ngoc Anh. “Development of a DNA chip for rapid detection of first-line and second-line drug resistances in Mycobacterium tuberculosis : Développement d’une puce à ADN pour la détection rapide de la résistance aux médicaments de première et seconde ligne chez Mycobacterium tuberculosis.” 2018. Doctoral Dissertation, Montpellier. Accessed January 15, 2021. http://www.theses.fr/2018MONTT074.

MLA Handbook (7^th Edition):

Nguyen, Thi Ngoc Anh. “Development of a DNA chip for rapid detection of first-line and second-line drug resistances in Mycobacterium tuberculosis : Développement d’une puce à ADN pour la détection rapide de la résistance aux médicaments de première et seconde ligne chez Mycobacterium tuberculosis.” 2018. Web. 15 Jan 2021.

Vancouver:

Nguyen TNA. Development of a DNA chip for rapid detection of first-line and second-line drug resistances in Mycobacterium tuberculosis : Développement d’une puce à ADN pour la détection rapide de la résistance aux médicaments de première et seconde ligne chez Mycobacterium tuberculosis. [Internet] [Doctoral dissertation]. Montpellier; 2018. [cited 2021 Jan 15]. Available from: http://www.theses.fr/2018MONTT074.

Council of Science Editors:

Nguyen TNA. Development of a DNA chip for rapid detection of first-line and second-line drug resistances in Mycobacterium tuberculosis : Développement d’une puce à ADN pour la détection rapide de la résistance aux médicaments de première et seconde ligne chez Mycobacterium tuberculosis. [Doctoral Dissertation]. Montpellier; 2018. Available from: http://www.theses.fr/2018MONTT074

Stellenbosch University

14. Kotze, Leigh Ann. Characterization of the innate and adaptive immune systems during active TB disease and during treatment.

Degree: PhD, Biomedical Sciences, 2019, Stellenbosch University

URL: http://hdl.handle.net/10019.1/105613

► ENGLISH ABSTRACT: Individuals presenting with symptoms of active tuberculosis (TB) disease currently undergo a lengthy diagnostic procedure, followed by an intense six-month treatment regimen. Delays… (more)

▼ ENGLISH ABSTRACT: Individuals presenting with symptoms of active tuberculosis (TB) disease currently undergo a lengthy diagnostic procedure, followed by an intense six-month treatment regimen. Delays in accurate diagnoses and severe treatment side effects contribute to low treatment adherence and drive the emergence of drug resistant Mycobacterium tuberculosis (M.tb) strains. Improvements in diagnostic technologies have allowed for same day diagnoses, however the roll-out of such devices are limited to settings with stable infrastructure. Additionally, many patients do not require the full treatment regimen when diagnosed early or when presenting with mild disease, however few reliable methods are available for identifying fast-responders. Immune biomarkers show great promise in addressing the need for improved diagnostic and treatment response prediction techniques. This study aimed to investigate multiple promising biomarkers, including (1) promising host diagnostic biomarkers for accurate discrimination of active TB disease from other diseases at point-of-care level; (2) promising host cell surface biomarkers for identifying treatment response shortly after treatment initiation; and also (3) functional host biomarkers for elucidating host-pathogen interaction responses for translation into diagnostic or treatment response biomarkers. Host diagnostic biomarkers were investigated (Chapter 2) in individuals presenting with symptoms suggestive of active TB disease, stratified according to an algorithm based on a combination of clinical, radiological and laboratory findings. Nine acute-phase proteins were investigated in participants' serum, and a biosignature comprising the biomarkers C-reactive protein (CRP) and serum amyloid A (SAA), accurately discriminated between participants with and without active TB disease with a sensitivity of 87.4% and specificity of 75.7%, irrespective of human immunodeficiency virus (HIV) co-infection. The validated biosignature performance in Ascaris lumbricoides sensitized participants remained relatively stable (Chapter 3; Sensitivity of 78%; Specificity of 75%). Validation of this biosignature in scenarios where both HIV- and Ascaris co-infection were considered, identified a robust and reliable biosignature suitable for use in high-burden settings. Individuals with confirmed active TB disease and healthy controls were recruited to investigate cell surface biomarkers of treatment response (Chapter 4). Markers of interest (CD126, CD120b, CD62L, CD197, and CD58) were investigated via flow cytometry on various immune cell subsets across three time points (diagnosis, month 1, end of treatment). No markers were differentially expressed at month 1, whereas CD120b and CD58 were upregulated the end of treatment on CD4+ and CD8+ T-cells, limiting their use as early treatment response biomarkers. Innate and adaptive response cytokines were then investigated from isolated cell subsets (neutrophils, monocytes, T-cells, combination) and compared to whole blood under unstimulated and… Advisors/Committee Members: Walzl, Gerhard, Du Plessis, Nelita, Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Biomedical Sciences: Molecular Biology and Human Genetics..

Subjects/Keywords: Tuberculosis – Diagnosis; Tuberculosis – Treatment; Drug resistance in Mycobacterium tuberculosis; Natural immunity; Immune system; Biochemical markers

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kotze, L. A. (2019). Characterization of the innate and adaptive immune systems during active TB disease and during treatment. (Doctoral Dissertation). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/105613

Chicago Manual of Style (16^th Edition):

Kotze, Leigh Ann. “Characterization of the innate and adaptive immune systems during active TB disease and during treatment.” 2019. Doctoral Dissertation, Stellenbosch University. Accessed January 15, 2021. http://hdl.handle.net/10019.1/105613.

MLA Handbook (7^th Edition):

Kotze, Leigh Ann. “Characterization of the innate and adaptive immune systems during active TB disease and during treatment.” 2019. Web. 15 Jan 2021.

Vancouver:

Kotze LA. Characterization of the innate and adaptive immune systems during active TB disease and during treatment. [Internet] [Doctoral dissertation]. Stellenbosch University; 2019. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10019.1/105613.

Council of Science Editors:

Kotze LA. Characterization of the innate and adaptive immune systems during active TB disease and during treatment. [Doctoral Dissertation]. Stellenbosch University; 2019. Available from: http://hdl.handle.net/10019.1/105613

15. Rinaldi, Laura. The coprological diagnosis of gastrointestinal nematode infections in small ruminants.

Degree: 2014, Ghent University

URL: http://hdl.handle.net/1854/LU-5645001

► Infections with gastrointestinal nematodes (GIN) continue to represent a serious challenge to the health, welfare and productivity of grazing ruminants throughout the world. However, implementation… (more)

▼ Infections with gastrointestinal nematodes (GIN) continue to represent a serious challenge to the health, welfare and productivity of grazing ruminants throughout the world. However, implementation in research, diagnosis and surveillance of these parasites is still poor. The present thesis provided novel insights into the coprological diagnosis of GIN infections in small ruminants with particular emphasis on the significance, interpretation and limitations of different faecal egg count (FEC) techniques and the faecal egg count reduction test (FECRT). The literature review provides an in-depth analysis of FEC/FECRT, considering also their limitations and gaps. These aspects have important implications towards the achievement of a proper diagnosis of GIN in small ruminants, particularly when FEC/FECRT are used in epidemiological surveys, anthelmintic drug efficacy studies and monitoring of control programs. The calibration and performance of different FEC techniques and the effect of different faecal preservation methods on GIN egg counts was assessed under field conditions in southern Italy. FLOTAC, saturated sodium chloride, and vacuum packing at +4°C resulted the most accurate FEC technique, flotation solution and preservation method, respectively, for reliable GIN egg counts in sheep. A longitudinal study of GIN egg counts was conducted on naturally infected dairy goats to evaluate the effects of the hour of sample collection on FECs and the relationship between FECs and worm burden. The results indicated no significant difference in FECs within 24h, but they showed a significant difference across the 14 months. There was also a significant correlation between FECs and GIN worm burden in particular regarding Haemonchus contortus. A further field study was conducted to evaluate the efficacy of anthelminthic drugs against GIN in small ruminants in southern Italy by means of three FECR formulae that mainly differ whether a control group was included. The efficacy was evaluated for 4 anthelminthics (levamisole, ivermectin, moxidectin and monepantel). A reduced efficacy was claimed when FECR was <95% and the lower limit of 95% confidence interval (LCL) <90%. Mean values of FECR were very high (>99%) and LCLs were generally high (>90%) for all the anthelminthic drugs regardless of the formula. Easy methods for FECRT (without control groups) are suggested. The value of pooled faecal samples for FEC and FECR of GIN was assessed in 10 sheep farms in southern Italy. We also verified whether the accuracy was affected by pool size (5, 10 and 20 individual samples) and analytic sensitivity (10, 15 and 50 EPG) of the FEC technique. GIN FECs of pooled samples correlated positively with mean FECs of individual samples, with very high correlation coefficients (ranging from 0.94 to 0.99) across the 3 different pool sizes and analytic sensitivities. Pooling faecal samples using the Mini-FLOTAC technique holds promise as a valid strategy for assessing FECs and FECR of GIN in small ruminants. Finally, the present assessments and… Advisors/Committee Members: Vercruysse, Jozef, Cringoli, Giuseppe, Levecke, Bruno.

Subjects/Keywords: Veterinary Sciences; GASTROINTESTINAL; Drug; DIAGNOSIS; faecal egg count (FEC); faecal egg count reduction test (FECRT)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rinaldi, L. (2014). The coprological diagnosis of gastrointestinal nematode infections in small ruminants. (Thesis). Ghent University. Retrieved from http://hdl.handle.net/1854/LU-5645001

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rinaldi, Laura. “The coprological diagnosis of gastrointestinal nematode infections in small ruminants.” 2014. Thesis, Ghent University. Accessed January 15, 2021. http://hdl.handle.net/1854/LU-5645001.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rinaldi, Laura. “The coprological diagnosis of gastrointestinal nematode infections in small ruminants.” 2014. Web. 15 Jan 2021.

Vancouver:

Rinaldi L. The coprological diagnosis of gastrointestinal nematode infections in small ruminants. [Internet] [Thesis]. Ghent University; 2014. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/1854/LU-5645001.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rinaldi L. The coprological diagnosis of gastrointestinal nematode infections in small ruminants. [Thesis]. Ghent University; 2014. Available from: http://hdl.handle.net/1854/LU-5645001

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

16. Rodrigues, Cintia Capucho. Trauma vascular: ocorrência em pessoas submetidas a tratamento quimioterápico para câncer de mama.

Degree: Mestrado, Enfermagem Fundamental, 2010, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/22/22132/tde-04082010-133246/ ;

► O câncer de mama é uma preocupação de saúde pública por sua grande incidência na população. A quimioterapia é a estratégia de tratamento mais empregada… (more)

▼ O câncer de mama é uma preocupação de saúde pública por sua grande incidência na população. A quimioterapia é a estratégia de tratamento mais empregada e dentre as formas de ser administrada, a mais comum é a intravenosa. A maioria das drogas citotóxicas é irritante ou vesicante, passível de promover trauma vascular. A pesquisa teve como objetivos: verificar a ocorrência de trauma vascular, oriundo do procedimento de punção venosa periférica, em pessoas submetidas à quimioterapia ambulatorial no tratamento do câncer de mama; identificar as manifestações clínicas de trauma vascular no local de punção venosa periférica para quimioterapia; verificar a existência de associação entre a ocorrência do trauma vascular e as variáveis estudadas; descrever a evolução temporal da ocorrência e continuidade do trauma vascular. Foram observadas 30 pacientes, durante 188 sessões. Quanto à caracterização da amostra, 93,3% das pacientes apresentaram o diagnóstico Carcinoma Ductal Invasivo, 3,3% Carcinoma Lobular Invasivo e 3,3% carcinoma metaplásico condróide; quanto ao estadiamento clínico os de maior porcentagem foram IIIA e IIIB com 26,7% cada um. Quanto ao programa de quimioterapia, 36,6% fizeram uso de Fluorouracil, Epirrubicina e Ciclofosfamida e 56,67% de uma combinação quatro Ciclos de Epirrubicina e Ciclofosfamida e quatro ciclos de Docetaxel associado ou não ao Trastuzumab. Outra característica, a presença de dor antes do inicio da quimioterapia, foi observada no ciclo 1 (10%), ciclo 2 (26,7%), ciclo 3 (36,7%), ciclo 4 (23,3%), ciclo 5 (26,67%), ciclo 6 (40%), ciclo 7 (14,3%) e ciclo 8 (14%); dentre as pacientes que apresentaram dor, os locais predominantes foram os membros superiores e inferiores. As características principais identificadas em relação aos acessos venosos foram visibilidade, em mais de 50% dos acessos escolhidos; palpabilidade, presente em 100% dos acessos; mobilidade, sendo que mais de 50% das veias eram fixas; alem de a maioria apresentar trajetória retilínea e com elasticidade preservada. Quanto ao local de inserção, predominou (>60%) o dorso da mão. Houve também um aumento de repetidas punções para se conseguir um acesso ao longo dos ciclos. Quanto ao material, identificou-se preferência pelos materiais flexíveis - vialon ou tefon - de calibre predominantemente 24G, fixados com adesivo micropore. Quanto ao sistema utilizado para infusão foi utilizado o frasco de plástico flexível e colabável, com equipo simples e com sistema extensor de duas vias. Nos 188 ciclos observados foram identificados como trauma vascular tardio: diminuição da elasticidade do vaso (63); hiperpigmentação (69); endurecimento (46); engurgitamento (10) e cordão venoso (30). Como manifestações imediatas: infiltração em 1,59% dos ciclos, flebite durante a infusão (35) e queixas de dor durante a infusão (9). Ao se comparar as médias de problemas (trauma vascular) apresentados pelas pacientes que fizeram uso de Fluorouracil, Epirrubicina e Ciclofosfamida e as que fizeram uso de Epirrubicina, Ciclofosfamida, e Docetaxel, foi identificado… Advisors/Committee Members: Carvalho, Emilia Campos de.

Subjects/Keywords: diagnóstico de enfermagem; drug therapy; enfermagem oncologica; nursing diagnosis; oncologic nursing; quimioterapia; trauma vascular; vascular trauma

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rodrigues, C. C. (2010). Trauma vascular: ocorrência em pessoas submetidas a tratamento quimioterápico para câncer de mama. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/22/22132/tde-04082010-133246/ ;

Chicago Manual of Style (16^th Edition):

Rodrigues, Cintia Capucho. “Trauma vascular: ocorrência em pessoas submetidas a tratamento quimioterápico para câncer de mama.” 2010. Masters Thesis, University of São Paulo. Accessed January 15, 2021. http://www.teses.usp.br/teses/disponiveis/22/22132/tde-04082010-133246/ ;.

MLA Handbook (7^th Edition):

Rodrigues, Cintia Capucho. “Trauma vascular: ocorrência em pessoas submetidas a tratamento quimioterápico para câncer de mama.” 2010. Web. 15 Jan 2021.

Vancouver:

Rodrigues CC. Trauma vascular: ocorrência em pessoas submetidas a tratamento quimioterápico para câncer de mama. [Internet] [Masters thesis]. University of São Paulo; 2010. [cited 2021 Jan 15]. Available from: http://www.teses.usp.br/teses/disponiveis/22/22132/tde-04082010-133246/ ;.

Council of Science Editors:

Rodrigues CC. Trauma vascular: ocorrência em pessoas submetidas a tratamento quimioterápico para câncer de mama. [Masters Thesis]. University of São Paulo; 2010. Available from: http://www.teses.usp.br/teses/disponiveis/22/22132/tde-04082010-133246/ ;

Stellenbosch University

17. Liwa, Anthony Cuthbert. Pharmacokinetics and dosing rationale of Para-Aminosalicylic acid in children and the evaluation of the in vitro metabolism of Ethionamide, Terizidone and Para-aminosalicylic acid.

Degree: MScMedSc, Medicine, 2012, Stellenbosch University

URL: http://hdl.handle.net/10019.1/20165

►

ENGLISH ABSTRACT: BACKGROUND: The emergence of mycobacterium tuberculosis resistance to first line drugs has renewed interest in second-line anti-tuberculosis drugs. Generally, Paraaminosalicylic acid (PAS) is… (more)

▼

ENGLISH ABSTRACT: BACKGROUND: The emergence of mycobacterium tuberculosis resistance to first line drugs has renewed interest in second-line anti-tuberculosis drugs. Generally, Paraaminosalicylic acid (PAS) is less potent and frequently more toxic than the first line drugs. Furthermore, the pharmacokinetics of PAS in children has not been well characterized. AIMS: The aims of the present study were (1) to determine the pharmacokinetics of PAS in pediatric patients, (2) to describe the discrepancy between children and adult pharmacokinetics and the appropriate dosing regimen of PAS and (3) to investigate the potential of the second-line anti-tuberculosis drugs PAS, terizidone and ethionamide (often used as first-line drug in children) to inhibit the catalytic activities of CYP450 1A2 and 2C9. PATIENTS: Twenty two patients with drug resistant tuberculosis were included in the study. Ten patients were children with mean age of 4.2 years (range: 1 to 12 years). Twelve patients were adults with mean age of 31.3 years (range: 18 to 53). 4 children (40%) and 4 adults (33.3%) were HIV positive and were on ART. METHODS: Children received 75 mg/kg twice daily on the first visit and after two weeks they received 150 mg/kg once. Adults received a standard 4 g twice daily. Blood samples were taken at different time points after the dose. In the additional study, the inhibitory effects of PAS, ethionamide and terizidone on phenacetin O-deethylation, a marker substrate of CYP1A2 and diclofenac 4’-hydroxylation, a marker substrate of CYP2C9, were studied using human liver microsomes. RESULTS: For the 75 mg/kg dose, the mean AUC was 233.3 =g•h/ml and the mean CL was 10.4 l/h/kg. The mean of the observed Cmax of the drug was 45.4 =g/ml and the mean Tmax was 4.8 hrs. For the 150 mg/kg dose, the mean AUC of PAS was 277.9 =g•h/ml and the mean CL was 47.1 l/h/kg. The mean of the observed Cmax of the drug was 56.5 =g/ml and the mean Tmax was 4.8 hrs. On the first visit the mean AUC was 368 =g•h/ml and the mean CL was 13.2 l/h/kg. The mean of the observed Cmax of PAS was 51.3 =g/ml and the mean Tmax was 5.2 hrs. On the second visit the mean AUC was 230 =g•h/ml and the mean CL was 23.9 l/h/kg. The mean of the observed Cmax of PAS was 37.6 =g/ml and the mean Tmax was 5.2 hrs. The comparisons between pharmacokinetics profile of PAS and patients characteristics e.g. age, indicated no statistically significant differences between children (both treatment regimens) and adult patients as well as HIV positive and negative patients. In the in vitro study, all drugs demonstrated no inhibition potency towards the investigated CYP450 enzymes. CONCLUSIONS:The dose of 75 mg/kg twice daily in children appears to be appropriate to achieve serum concentration above the PAS minimum inhibitory concentration of approximately 1 =g/ml. PAS, ethionamide and terizidone are unlikely to affect the metabolism of concomitantly administered medications that are metabolized by either CYP450 1A2 and/or 2C9 isoenzymes.

AFRIKAANSE…

Advisors/Committee Members: Bouic, Patrick, Stellenbosch University. Faculty of Health Sciences. Dept. of Medicine. Pharmacology..

Subjects/Keywords: Pharmacology; Dissertations – Pharmacology; Drug resistance in tuberculosis; Pharmacokinetics; Para-aminosalycylic acid (PAS); Tuberculosis in children – Diagnosis; Tuberculosis in children – Treatment; Medicine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Liwa, A. C. (2012). Pharmacokinetics and dosing rationale of Para-Aminosalicylic acid in children and the evaluation of the in vitro metabolism of Ethionamide, Terizidone and Para-aminosalicylic acid. (Masters Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/20165

Chicago Manual of Style (16^th Edition):

Liwa, Anthony Cuthbert. “Pharmacokinetics and dosing rationale of Para-Aminosalicylic acid in children and the evaluation of the in vitro metabolism of Ethionamide, Terizidone and Para-aminosalicylic acid.” 2012. Masters Thesis, Stellenbosch University. Accessed January 15, 2021. http://hdl.handle.net/10019.1/20165.

MLA Handbook (7^th Edition):

Liwa, Anthony Cuthbert. “Pharmacokinetics and dosing rationale of Para-Aminosalicylic acid in children and the evaluation of the in vitro metabolism of Ethionamide, Terizidone and Para-aminosalicylic acid.” 2012. Web. 15 Jan 2021.

Vancouver:

Liwa AC. Pharmacokinetics and dosing rationale of Para-Aminosalicylic acid in children and the evaluation of the in vitro metabolism of Ethionamide, Terizidone and Para-aminosalicylic acid. [Internet] [Masters thesis]. Stellenbosch University; 2012. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10019.1/20165.

Council of Science Editors:

Liwa AC. Pharmacokinetics and dosing rationale of Para-Aminosalicylic acid in children and the evaluation of the in vitro metabolism of Ethionamide, Terizidone and Para-aminosalicylic acid. [Masters Thesis]. Stellenbosch University; 2012. Available from: http://hdl.handle.net/10019.1/20165

Northeastern University

18. Johnson, Michael James. Analysis of the structure and function of endocannabinoid-hydrolyzing enzymes using biophysical and nanomedical techniques.

Degree: School of Pharmacy, 2015, Northeastern University

URL: http://hdl.handle.net/2047/D20197124

► Presented here is a systematic structural, and functional study of endocannabinoid metabolizing enzymes, including: a potential biomarker for breast cancer and the development of a… (more)

▼ Presented here is a systematic structural, and functional study of endocannabinoid metabolizing enzymes, including: a potential biomarker for breast cancer and the development of a novel nanoplatform for studying these membrane proteins. Investigating the impact of phospholipid bilayers on the structure and function of membrane proteins is an essential precursor to developing drugs that target these dynamic systems. The membrane-associated serine hydrolase, monoacylglycerol lipase (MGL), and the membrane-bound serine hydrolase, fatty acid amide hydrolase (FAAH), are well-recognized therapeutic targets that regulate endocannabinoid signaling. In particular, overexpression of MGL in certain tumor cells elevates the levels of pro-tumorigenic signaling lipids, and as such, MGL regulates a fatty acid network that promotes pathogenesis in some cancers. Reported here is the application of phospholipid bilayer nanodiscs that mimic the native cell membrane environment to evaluate the effects of membrane systems on the catalytic properties, and conformational dynamics, of human MGL (hMGL) and rat FAAH (rFAAH). Specifically, hMGL's kinetic properties (apparent maximum velocity [V_MAX] and substrate affinity [K_M]) were enhanced in the presence of anionic and charge-neutral phospholipid bilayer nanodiscs. In order to examine further the effects of modulating the activity of hMGL, a novel nano-medicinal agent (derived from a dynamic class of nano-materials that can be applied to in vitro, in vivo, and clinical applications) was synthesized, and characterized. Nanoparticles exist in a physical state between that of bulk material and a single molecule. In this transitional state, surface properties and quantum-mechanical dynamics can be "tuned" simply by altering particle size and shape. The `[email protected]' particle design proposed here presents a multi-lamellar nanoplatform for imaging, drug delivery, and therapeutic applications that, in this case, target the endocannabinoid system. Another novel imaging motif, proposed here involves probing the mechanism of hMGL inhibition by 5-(4-hydroxyphenyl)-pentanesulfonyl fluoride (AM3506) using biochemical and mass spectrometric (MS) approaches. After hMGL was treated with AM3506, the conversion of sulfonyl serine (Ser¹²²) to dehydroalanine via a -elimination mechanism was observed, and confirmed by tandem MS analysis. Targeting the resultant dehydroalanine hMGL with thiophenol resulted in the conversion of Ser¹²² to S-phenyl-cysteine (addition of 92 Da), which demonstrates a selective approach for serine hydrolase modification at the catalytic serine. This modification confers a new function to in this case- hMGL without genetic manipulation. The results of this work contribute to the understanding of key regulatory pathway involved in breast cancer progression (as well as other disease states) and provides evidence of the feasibility of the development of a novel, pharmacologic intervention toward the diagnosis and treatment of metastatic…

Subjects/Keywords: AM3506; endocannabinoid; FAAH; MGL; nanodisc; Cannabinoids; Receptors; Therapeutic use; Lipase; Inhibitors; Hydrolases; Membrane proteins; Nanomedicine; Drug targeting; Breast; Cancer; Diagnosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Johnson, M. J. (2015). Analysis of the structure and function of endocannabinoid-hydrolyzing enzymes using biophysical and nanomedical techniques. (Doctoral Dissertation). Northeastern University. Retrieved from http://hdl.handle.net/2047/D20197124

Chicago Manual of Style (16^th Edition):

Johnson, Michael James. “Analysis of the structure and function of endocannabinoid-hydrolyzing enzymes using biophysical and nanomedical techniques.” 2015. Doctoral Dissertation, Northeastern University. Accessed January 15, 2021. http://hdl.handle.net/2047/D20197124.

MLA Handbook (7^th Edition):

Johnson, Michael James. “Analysis of the structure and function of endocannabinoid-hydrolyzing enzymes using biophysical and nanomedical techniques.” 2015. Web. 15 Jan 2021.

Vancouver:

Johnson MJ. Analysis of the structure and function of endocannabinoid-hydrolyzing enzymes using biophysical and nanomedical techniques. [Internet] [Doctoral dissertation]. Northeastern University; 2015. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2047/D20197124.

Council of Science Editors:

Johnson MJ. Analysis of the structure and function of endocannabinoid-hydrolyzing enzymes using biophysical and nanomedical techniques. [Doctoral Dissertation]. Northeastern University; 2015. Available from: http://hdl.handle.net/2047/D20197124

Universitat de Barcelona

19. Fernández Mondragón, Susana. Características de personalidad, estrategias de afrontamiento y calidad de vida en patología dual.

Degree: Departament de Psiquiatria i Psicobiologia Clínica, 2015, Universitat de Barcelona

URL: http://hdl.handle.net/10803/400879

► Dual Diagnosis (DD) is the coexistence of Substance Use Disorder (SUD) and Severe Mental Illness (SMI), especially when these are in the category of psychotic… (more)

▼ Dual Diagnosis (DD) is the coexistence of Substance Use Disorder (SUD) and Severe Mental Illness (SMI), especially when these are in the category of psychotic and affective pathologies. DD is associated with increased clinical and social problems compared to those seen in the presence of SUD and SMI alone, it is more frequent in males and its prevalence in the psychiatric population is greater than 50%. Factors underlying DD are extremely difficult to find because DD implies not only biological elements but also psychosocial ones. Advances in this field are key to improve not only our basic knowledge about mental disorders but also their treatment efficiency and relapse prevention. Our research focused on the analysis of personality characteristics, coping skills and quality of life in subjects with DD, compared to patients with either SMI or SUD. We selected these study variables based on both an extensive bibliographic review and the possible benefit to these that can be generated from our results. For the study of personality characteristics we selected the Cloninger and Zuckerman psychobiological models with a more specific analysis of impulsivity based on the Dickman model. To evaluate coping skills in stressing situations, considered as protective factors in psychosocial risk situations and substance abuse, we selected the Coping Strategies Inventory developed by Tobin. Finally, the SF-36 scale of Ware & Sherbourne was used to evaluate quality of life. Our sample was composed of 102 males under treatment, between 25 and 55 years old and distributed in three groups: DD (n=34), SUD (n=34) and SMI (n=34). These subjects were abstinent for a minimum 6 months and stable for their SMI. The DD and SMI groups included 20 patients diagnosed with schizophrenia and 14 with major depression, which allowed us to assess whether the studied variables and SUD or SMI comorbidity can be affected by the type of SMI. Our results confirmed the existence of a clinical and social pattern in DD which results in an increased number of complications such as higher rate of suicidal attempts or quantity of administered psychopharmacs. DD is a risk factor to early drugs intake, being multi-drug addiction (alcohol, cocaine and cannabis especially) the most common feature. The DD group presented a personality profile characterized by higher sensation seeking and impulsivity, both traits typical of SUD and considered a risk factor to early drugs intake and worse treatment response. DD showed problems with frustration tolerance (low persistence) and tendency to avoid aversive stimulus (high harm avoidance), traits associated to SMI. The presence of schizophrenia, especially in DD, in comparison to depression, has been related to more extreme personality traits such as high sensation seeking, reward dependence and impulsivity and low capacity to take responsibility for their own decisions. A greater use of dysfunctional coping skills by DD patients was confirmed, mainly the emotional ones, produced by the lack of abilities to… Advisors/Committee Members: [email protected] (authoremail), false (authoremailshow), Adan Puig, Ana (director), true (authorsendemail).

Subjects/Keywords: Diagnòstic dual; Patología dual; Dual diagnosis; Psicopatologia; Psicopatología; Pathological psychology; Drogoaddicció; Drogadicción; Drug addiction; Ciències de la Salut; 616.89

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fernández Mondragón, S. (2015). Características de personalidad, estrategias de afrontamiento y calidad de vida en patología dual. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/400879

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fernández Mondragón, Susana. “Características de personalidad, estrategias de afrontamiento y calidad de vida en patología dual.” 2015. Thesis, Universitat de Barcelona. Accessed January 15, 2021. http://hdl.handle.net/10803/400879.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fernández Mondragón, Susana. “Características de personalidad, estrategias de afrontamiento y calidad de vida en patología dual.” 2015. Web. 15 Jan 2021.

Vancouver:

Fernández Mondragón S. Características de personalidad, estrategias de afrontamiento y calidad de vida en patología dual. [Internet] [Thesis]. Universitat de Barcelona; 2015. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10803/400879.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fernández Mondragón S. Características de personalidad, estrategias de afrontamiento y calidad de vida en patología dual. [Thesis]. Universitat de Barcelona; 2015. Available from: http://hdl.handle.net/10803/400879

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université Paris-Sud – Paris XI

20. Gomgnimbou, Kireopori michel. Nouvelles méthodes de diagnostic, de contrôle et de surveillance de la tuberculose à bacilles sensibles ou multirésistants dans les pays à forte co-infection au VIH : applications en Santé Publique : New methods for diagnosis, control and surveillance of susceptible or multi-drug resistant tuberculosis in countries with high HIV co-infection : public Health applications.

Degree: Docteur es, Biologie, 2013, Université Paris-Sud – Paris XI

URL: http://www.theses.fr/2013PA112210

►

La tuberculose est une maladie ancienne et ré-émergente qui constitue un véritable problème de santé publique dans le monde. L’émergence de la tuberculose à souches… (more)

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La tuberculose est une maladie ancienne et ré-émergente qui constitue un véritable problème de santé publique dans le monde. L’émergence de la tuberculose à souches de M. tuberculosis multirésistantes et ultrarésistantes aux antituberculeux en plus de la pandémie du VIH/Sida, représentent un défi majeur dans la lutte contre la tuberculose pour son contrôle et son élimination. Ce contrôle de la tuberculose nécessite des mesures en santé publique et au niveau de l’individu. Ces mesures concernent la disponibilité et l’accessibilité à des tests de diagnostic rapides, des traitements efficaces et des outils de surveillance et de contrôle.Nos travaux concernent la recherche, le développement et la validation de méthodes moléculaires multiplexées, souvent basées sur le polymorphisme des loci CRISPR (Clustered Regularly Interspersed Palindromic Repeats). Elles sont rapides, à haut débit, moins onéreuses et applicables pour la santé publique (transmission de la tuberculose sensible et multirésistante, évaluation des programmes nationaux de tuberculose) mais aussi pour un meilleur diagnostic dans l’intérêt du patient (antibiogramme moléculaire, identification infra-spécifique). C’est ainsi que nous avons développé et validé le spoligoriftyping (méthode de génotypage combiné à la détection moléculaire de la résistance de M. tuberculosis à la rifampicine), le “TB-SPRINT” (Spoligoriftyping plus la détection moléculaire de la résistance à l’isoniazide) et le sous-typage de M. africanum. Ces différentes méthodes, aux performances (sensibilité/spécificité) satisfaisantes (99/100% pour le spoligoriftyping, 95/100% en moyenne pour le “TB-SPRINT”) ont servi à des études d’épidémiologie moléculaire dans des pays comme le Pakistan, le Nigéria et le Brésil. D’autres travaux en cours portent sur le génotypage basé sur les CRISPR d’autres espèces (Salmonella enterica, Legionella pneumophila) et sur des études de génomique comparative. Nos tests, utilisés en routine, replacent le laboratoire au cœur de la lutte anti-tuberculeuse et permettront d’importantes avancées en Santé Publique et Microbiologie médicale et environnementale.

Tuberculosis (TB) remains a major public health concern worldwide despite all the efforts to fight this disease. The emergence of multi drug and extensively drug resistant TB and the pandemic of HIV/AIDS constitute major threats and challenge for the TB control and eradication. TB control requires measures in public health and in individual level as accessibility to tests for early diagnostic, effective treatment and tools for tuberculosis surveillance and control.The goals of this work were research, development and validation of new molecular multiplexed methods based on polymorphism of the CRISPR (Clustered Regularly Interspersed Palindromic Repeats) loci and single nucleotides polymorphisms. These methods are rapid, high throughput, cheap and can be applied both for public health purposes (transmission of susceptible and multi-drug resistant tuberculosis, evaluation of national TB programs) as for interest…

Advisors/Committee Members: Sola, Christophe (thesis director).

Subjects/Keywords: Tuberculose; Outils de diagnostic; Génotypage; Épidémiologie moléculaire; Multirésistance; Santé publique; Tuberculosis; Diagnosis tools; Genotyping; Molecular epidemiology; Muti-drug resistance; Public health

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gomgnimbou, K. m. (2013). Nouvelles méthodes de diagnostic, de contrôle et de surveillance de la tuberculose à bacilles sensibles ou multirésistants dans les pays à forte co-infection au VIH : applications en Santé Publique : New methods for diagnosis, control and surveillance of susceptible or multi-drug resistant tuberculosis in countries with high HIV co-infection : public Health applications. (Doctoral Dissertation). Université Paris-Sud – Paris XI. Retrieved from http://www.theses.fr/2013PA112210

Chicago Manual of Style (16^th Edition):

Gomgnimbou, Kireopori michel. “Nouvelles méthodes de diagnostic, de contrôle et de surveillance de la tuberculose à bacilles sensibles ou multirésistants dans les pays à forte co-infection au VIH : applications en Santé Publique : New methods for diagnosis, control and surveillance of susceptible or multi-drug resistant tuberculosis in countries with high HIV co-infection : public Health applications.” 2013. Doctoral Dissertation, Université Paris-Sud – Paris XI. Accessed January 15, 2021. http://www.theses.fr/2013PA112210.

MLA Handbook (7^th Edition):

Gomgnimbou, Kireopori michel. “Nouvelles méthodes de diagnostic, de contrôle et de surveillance de la tuberculose à bacilles sensibles ou multirésistants dans les pays à forte co-infection au VIH : applications en Santé Publique : New methods for diagnosis, control and surveillance of susceptible or multi-drug resistant tuberculosis in countries with high HIV co-infection : public Health applications.” 2013. Web. 15 Jan 2021.

Vancouver:

Gomgnimbou Km. Nouvelles méthodes de diagnostic, de contrôle et de surveillance de la tuberculose à bacilles sensibles ou multirésistants dans les pays à forte co-infection au VIH : applications en Santé Publique : New methods for diagnosis, control and surveillance of susceptible or multi-drug resistant tuberculosis in countries with high HIV co-infection : public Health applications. [Internet] [Doctoral dissertation]. Université Paris-Sud – Paris XI; 2013. [cited 2021 Jan 15]. Available from: http://www.theses.fr/2013PA112210.

Council of Science Editors:

Gomgnimbou Km. Nouvelles méthodes de diagnostic, de contrôle et de surveillance de la tuberculose à bacilles sensibles ou multirésistants dans les pays à forte co-infection au VIH : applications en Santé Publique : New methods for diagnosis, control and surveillance of susceptible or multi-drug resistant tuberculosis in countries with high HIV co-infection : public Health applications. [Doctoral Dissertation]. Université Paris-Sud – Paris XI; 2013. Available from: http://www.theses.fr/2013PA112210

University of Gothenburg / Göteborgs Universitet

21. Herlitz, Johan, 1949-. Bedömning och begränsning av hjärtinfarktens storlek : en interventionsstudie med metoprolol.

Degree: 1982, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/11619

Subjects/Keywords: Medicin Allmänt Myocardial infarction: diagnosis; Myocardial infarction: drug therapy

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APA (6^th Edition):

Herlitz, Johan, 1. (1982). Bedömning och begränsning av hjärtinfarktens storlek : en interventionsstudie med metoprolol. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/11619

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Herlitz, Johan, 1949-. “Bedömning och begränsning av hjärtinfarktens storlek : en interventionsstudie med metoprolol.” 1982. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed January 15, 2021. http://hdl.handle.net/2077/11619.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Herlitz, Johan, 1949-. “Bedömning och begränsning av hjärtinfarktens storlek : en interventionsstudie med metoprolol.” 1982. Web. 15 Jan 2021.

Vancouver:

Herlitz, Johan 1. Bedömning och begränsning av hjärtinfarktens storlek : en interventionsstudie med metoprolol. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 1982. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2077/11619.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Herlitz, Johan 1. Bedömning och begränsning av hjärtinfarktens storlek : en interventionsstudie med metoprolol. [Thesis]. University of Gothenburg / Göteborgs Universitet; 1982. Available from: http://hdl.handle.net/2077/11619

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. Krijnen, Pieta. Studies on diagnosis and treatment of renal artery stenosis.

Degree: Department of Public Health, 2004, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/51674

► textabstractThis thesis describes studies on ~onosis and treatment of renal artery stenosis in patients with drug-resistant hypertension. In Chapter 1, the clinical problem of renal… (more)

Subjects/Keywords: stenosis; diagnosis; treatment; hypertension; drug-resistant; arteria renalis

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APA (6^th Edition):

Krijnen, P. (2004). Studies on diagnosis and treatment of renal artery stenosis. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/51674

Chicago Manual of Style (16^th Edition):

Krijnen, Pieta. “Studies on diagnosis and treatment of renal artery stenosis.” 2004. Doctoral Dissertation, Erasmus University Medical Center. Accessed January 15, 2021. http://hdl.handle.net/1765/51674.

MLA Handbook (7^th Edition):

Krijnen, Pieta. “Studies on diagnosis and treatment of renal artery stenosis.” 2004. Web. 15 Jan 2021.

Vancouver:

Krijnen P. Studies on diagnosis and treatment of renal artery stenosis. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2004. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/1765/51674.

Council of Science Editors:

Krijnen P. Studies on diagnosis and treatment of renal artery stenosis. [Doctoral Dissertation]. Erasmus University Medical Center; 2004. Available from: http://hdl.handle.net/1765/51674

23. NGO TRA MY. WHOLE-GENOME SEQUENCING AND GENE-BASED DIAGNOSIS IN THE COMPLEX BATTLE AGAINST DRUG-RESISTANT TUBERCULOSIS.

Degree: 2019, National University of Singapore

URL: https://scholarbank.nus.edu.sg/handle/10635/167852

Subjects/Keywords: Whole-genome sequencing; tuberculosis; drug-resistant; diagnosis; prediction; misspecification

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APA (6^th Edition):

MY, N. T. (2019). WHOLE-GENOME SEQUENCING AND GENE-BASED DIAGNOSIS IN THE COMPLEX BATTLE AGAINST DRUG-RESISTANT TUBERCULOSIS. (Thesis). National University of Singapore. Retrieved from https://scholarbank.nus.edu.sg/handle/10635/167852

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

MY, NGO TRA. “WHOLE-GENOME SEQUENCING AND GENE-BASED DIAGNOSIS IN THE COMPLEX BATTLE AGAINST DRUG-RESISTANT TUBERCULOSIS.” 2019. Thesis, National University of Singapore. Accessed January 15, 2021. https://scholarbank.nus.edu.sg/handle/10635/167852.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

MY, NGO TRA. “WHOLE-GENOME SEQUENCING AND GENE-BASED DIAGNOSIS IN THE COMPLEX BATTLE AGAINST DRUG-RESISTANT TUBERCULOSIS.” 2019. Web. 15 Jan 2021.

Vancouver:

MY NT. WHOLE-GENOME SEQUENCING AND GENE-BASED DIAGNOSIS IN THE COMPLEX BATTLE AGAINST DRUG-RESISTANT TUBERCULOSIS. [Internet] [Thesis]. National University of Singapore; 2019. [cited 2021 Jan 15]. Available from: https://scholarbank.nus.edu.sg/handle/10635/167852.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

MY NT. WHOLE-GENOME SEQUENCING AND GENE-BASED DIAGNOSIS IN THE COMPLEX BATTLE AGAINST DRUG-RESISTANT TUBERCULOSIS. [Thesis]. National University of Singapore; 2019. Available from: https://scholarbank.nus.edu.sg/handle/10635/167852

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Tech

24. Bullock, Joseph Edward. Mental Health and Substance Abuse Professionals' Attitudes Toward Dually Diagnosed Clients in a Community-Based Treatment Center.

Degree: EdD, Educational Leadership and Policy Studies, 2002, Virginia Tech

URL: http://hdl.handle.net/10919/26713

► Mental health and substance abuse treatment systems have a history of incompatible philosophies and conflicts that have been associated with poor treatment outcomes for persons… (more)

▼ Mental health and substance abuse treatment systems have a history of incompatible philosophies and conflicts that have been associated with poor treatment outcomes for persons dually diagnosed. The purpose of this study was to determine whether or not there are differences in attitudes between mental health and substance abuse professionals toward the dually diagnosed client and whether or not academic discipline, levels of training and experience, occupation, and amount of contact affect the attitudes of these professional groups. A non-experimental survey research design was used for this study, and data were collected by means of a revised Opinions About Mental Illness (OMI) survey instrument and supplemental demographic questionnaire. The modified OMI instrument was piloted by a panel of subject matter experts experienced in the treatment of persons who are dually diagnosed in which they rated each item for favorableness to concepts of dual diagnosis. The modified OMI survey and a demographic questionnaire were administered to a sample consisting of mental health and substance abuse professionals employed at a local community mental health center. A total of 86 respondents representing 95% of the sample population completed the modified OMI survey and demographic questionnaire. Data were analyzed using descriptive, independent sample t-test, and multiple analysis of variance (MANOVA) statistics. Results revealed no statistically significant differences in attitude between mental health and substance abuse professionals toward dually diagnosed clients. Analysis of the independent variables academic discipline, level of training and experience, occupation, and amount of contact demonstrated no significant interaction effects between mental health and substance abuse professionals. Despite the absence of statistically significant differences in attitude between the mental health and substance abuse professionals, the similarities may be significant in terms of the psychological value for building positive relationships. The atmosphere of agency culture and the significance of co-location of mental health and substance abuse professionals were also potentially important factors in the outcome of the present study. Advisors/Committee Members: Madison-Colmore, Octavia D. (committeechair), Lichtman, Marilyn V. (committee member), Brown, Ruby (committee member), Hutchins, David E. (committee member), Maat, Mercedes ter (committee member).

Subjects/Keywords: Counseling; Attitudes; Mental Illness; Dual Diagnosis; Alcohol and Drug

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bullock, J. E. (2002). Mental Health and Substance Abuse Professionals' Attitudes Toward Dually Diagnosed Clients in a Community-Based Treatment Center. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/26713

Chicago Manual of Style (16^th Edition):

Bullock, Joseph Edward. “Mental Health and Substance Abuse Professionals' Attitudes Toward Dually Diagnosed Clients in a Community-Based Treatment Center.” 2002. Doctoral Dissertation, Virginia Tech. Accessed January 15, 2021. http://hdl.handle.net/10919/26713.

MLA Handbook (7^th Edition):

Bullock, Joseph Edward. “Mental Health and Substance Abuse Professionals' Attitudes Toward Dually Diagnosed Clients in a Community-Based Treatment Center.” 2002. Web. 15 Jan 2021.

Vancouver:

Bullock JE. Mental Health and Substance Abuse Professionals' Attitudes Toward Dually Diagnosed Clients in a Community-Based Treatment Center. [Internet] [Doctoral dissertation]. Virginia Tech; 2002. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10919/26713.

Council of Science Editors:

Bullock JE. Mental Health and Substance Abuse Professionals' Attitudes Toward Dually Diagnosed Clients in a Community-Based Treatment Center. [Doctoral Dissertation]. Virginia Tech; 2002. Available from: http://hdl.handle.net/10919/26713

Stellenbosch University

25. Barnard, Marinus. Diagnostic utility of the line probe assay for the detection of drug resistance in Mycobacterium tuberculosis.

Degree: PhD, Biomedical Sciences, 2013, Stellenbosch University

URL: http://hdl.handle.net/10019.1/79807

► ENGLISH ABSTRACT: The epidemic levels of drug-resistant tuberculosis (DR-TB) in high-burden countries such as South Africa, which is currently ranked as third highest in the… (more)

▼ ENGLISH ABSTRACT: The epidemic levels of drug-resistant tuberculosis (DR-TB) in high-burden countries such as South Africa, which is currently ranked as third highest in the world, is the result of a synergistic relationship between the increased transmission of DR strains, poor patient adherence as well as Human-Immunodeficiency Virus (HIV)-coinfection. The impact of these combined factors on the rise of DR-TB led to an urgent need for the development of new diagnostic tools to rapidly detect TB and its associated drug susceptibility profile. The Foundation for Innovative New Diagnostics (FIND) has taken the onus upon them to ensure that laboratory strengthening becomes a reality by having developed, and still developing, new diagnostic assays in order to improve the laboratory turn-around time (TAT), whereby the transmission of DR-TB strains can be stopped. Laboratory strengthening does not solely rely on new diagnostic assays alone, and thus a Quality Management System, discussed in the dissertation, must be in place to ensure that the rapid result is accurate and reliable. The series of studies encompassed in this dissertation includes methodological validations (both technical and operational) of rapid TB diagnostic assays in order to rapidly and accurately diagnose the disease, and thus reducing the diagnostic delay associated with conventional diagnostic platforms. The studies were conducted “in-house” at the National Health Laboratory Service (NHLS) Reference TB laboratory in Green Point, Cape Town, which is a high-volume public health laboratory. The need to rapidly detect resistance to the first line anti-tubercular drugs Isoniazid and Rifampicin was a priority and thus the performance of a commercial line probe assay (LPA), the GenoType®MTBDRplus Ver1.0 LPA, was assessed for use on smear positive direct patient material. The performance characteristics was superior to that of conventional drug susceptibility testing, where the sensitivity and specificity for the detection of multi-drug resistant TB (MDR-TB) was 98.8 and 100%, respectively, with results in 1-2 days. Based on this study, the World Health Organization (WHO) endorsed the use of molecular LPA for the rapid detection of DR-TB. Furthermore, the need for quality assurance associated with the GenoType®MTBDRplus LPA in the diagnostic laboratory is essential and thus a user manual for the molecular detection of Drug Resistant Tuberculosis in resource-limited settings has also been developed (http://www.finddiagnostics.org/export/sites/default/resource-center/reports brochures/docs/LPA LaboratoryManual22Mar2012.pdf) for which Global Laboratory Initiative (GLI) status is pending. With the outbreak of extensively drug resistant TB (XDR-TB) in Tugela Ferry area in KwaZulu-Natal and the rest of the world, the need to rapidly detect resistance to the second line drugs arose, and thus the performance characteristics of the GenoType®MTBDRsl LPA was assessed for use on smear positive direct patient material. The performance characteristics proved to be… Advisors/Committee Members: Warren, Robin Mark, Gey van Pittius, Nicolaas C., Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Biomedical Sciences. Division Molecular Biology and Human Genetics.

Subjects/Keywords: Molecular biology; Dissertations – Molecular biology; Drug resistance in tuberculosis – Diagnostic laboratory tests – South Africa – Cape Town; Drug resistant tuberculosis – Molecular diagnosis – South Africa – Cape Town

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Barnard, M. (2013). Diagnostic utility of the line probe assay for the detection of drug resistance in Mycobacterium tuberculosis. (Doctoral Dissertation). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/79807

Chicago Manual of Style (16^th Edition):

Barnard, Marinus. “Diagnostic utility of the line probe assay for the detection of drug resistance in Mycobacterium tuberculosis.” 2013. Doctoral Dissertation, Stellenbosch University. Accessed January 15, 2021. http://hdl.handle.net/10019.1/79807.

MLA Handbook (7^th Edition):

Barnard, Marinus. “Diagnostic utility of the line probe assay for the detection of drug resistance in Mycobacterium tuberculosis.” 2013. Web. 15 Jan 2021.

Vancouver:

Barnard M. Diagnostic utility of the line probe assay for the detection of drug resistance in Mycobacterium tuberculosis. [Internet] [Doctoral dissertation]. Stellenbosch University; 2013. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10019.1/79807.

Council of Science Editors:

Barnard M. Diagnostic utility of the line probe assay for the detection of drug resistance in Mycobacterium tuberculosis. [Doctoral Dissertation]. Stellenbosch University; 2013. Available from: http://hdl.handle.net/10019.1/79807

ETH Zürich

26. Flückiger, Simone Sophia. Adäquater Einsatz von Plasmaspiegelbestimmungen in der medikamentösen Therapie im alltäglichen Spitalbetrieb.

Degree: 1988, ETH Zürich

URL: http://hdl.handle.net/20.500.11850/139426

Subjects/Keywords: ARZNEIMITTELKONZENTRATION IN KÖRPERFLÜSSIGKEITEN UND GEWEBEN (PHARMAKOLOGIE); KLINISCHE DIAGNOSTIK; HERZGLYKOSIDE + DIGITALISGLYKOSIDE (PHARMAZIE); NEBENWIRKUNGEN VON ARZNEIMITTELN + BEHANDLUNGSKOMPLIKATIONEN; DRUG CONCENTRATION IN BODY FLUIDS AND TISSUES (PHARMACOLOGY); CLINICAL DIAGNOSIS; CARDENOLIDES + DIGITALIS GLYCOSIDES (PHARMACY); SIDE EFFECTS OF DRUGS + COMPLICATIONS DURING TREATMENT; info:eu-repo/classification/ddc/610; Medical sciences, medicine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Flückiger, S. S. (1988). Adäquater Einsatz von Plasmaspiegelbestimmungen in der medikamentösen Therapie im alltäglichen Spitalbetrieb. (Doctoral Dissertation). ETH Zürich. Retrieved from http://hdl.handle.net/20.500.11850/139426

Chicago Manual of Style (16^th Edition):

Flückiger, Simone Sophia. “Adäquater Einsatz von Plasmaspiegelbestimmungen in der medikamentösen Therapie im alltäglichen Spitalbetrieb.” 1988. Doctoral Dissertation, ETH Zürich. Accessed January 15, 2021. http://hdl.handle.net/20.500.11850/139426.

MLA Handbook (7^th Edition):

Flückiger, Simone Sophia. “Adäquater Einsatz von Plasmaspiegelbestimmungen in der medikamentösen Therapie im alltäglichen Spitalbetrieb.” 1988. Web. 15 Jan 2021.

Vancouver:

Flückiger SS. Adäquater Einsatz von Plasmaspiegelbestimmungen in der medikamentösen Therapie im alltäglichen Spitalbetrieb. [Internet] [Doctoral dissertation]. ETH Zürich; 1988. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/20.500.11850/139426.

Council of Science Editors:

Flückiger SS. Adäquater Einsatz von Plasmaspiegelbestimmungen in der medikamentösen Therapie im alltäglichen Spitalbetrieb. [Doctoral Dissertation]. ETH Zürich; 1988. Available from: http://hdl.handle.net/20.500.11850/139426

27. Pongsing, Yupaporn. Thai mothers' reports of symptoms in young children receiving chemotherapy.

Degree: PhD, 2010, Oregon Health Sciences University

URL: doi:10.6083/M42V2D2P ; http://digitalcommons.ohsu.edu/etd/425

Subjects/Keywords: Thailand; Drug Therapy; Child, Hospitalized; Neoplasms – diagnosis; Ethnic Groups; Mothers; Physician-Patient Relations

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pongsing, Y. (2010). Thai mothers' reports of symptoms in young children receiving chemotherapy. (Doctoral Dissertation). Oregon Health Sciences University. Retrieved from doi:10.6083/M42V2D2P ; http://digitalcommons.ohsu.edu/etd/425

Chicago Manual of Style (16^th Edition):

Pongsing, Yupaporn. “Thai mothers' reports of symptoms in young children receiving chemotherapy.” 2010. Doctoral Dissertation, Oregon Health Sciences University. Accessed January 15, 2021. doi:10.6083/M42V2D2P ; http://digitalcommons.ohsu.edu/etd/425.

MLA Handbook (7^th Edition):

Pongsing, Yupaporn. “Thai mothers' reports of symptoms in young children receiving chemotherapy.” 2010. Web. 15 Jan 2021.

Vancouver:

Pongsing Y. Thai mothers' reports of symptoms in young children receiving chemotherapy. [Internet] [Doctoral dissertation]. Oregon Health Sciences University; 2010. [cited 2021 Jan 15]. Available from: doi:10.6083/M42V2D2P ; http://digitalcommons.ohsu.edu/etd/425.

Council of Science Editors:

Pongsing Y. Thai mothers' reports of symptoms in young children receiving chemotherapy. [Doctoral Dissertation]. Oregon Health Sciences University; 2010. Available from: doi:10.6083/M42V2D2P ; http://digitalcommons.ohsu.edu/etd/425

28. Gouvêa, Michele Soares Gomes. Prevalência de resistência primária aos antivirais utilizados no tratamento da hepatite B entre pacientes com infecção crônica pelo vírus da hepatite B não submetidos a tratamento.

Degree: PhD, Ciências em Gastroenterologia, 2014, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5168/tde-04092014-163442/ ;

► O objetivo principal deste estudo foi avaliar a frequência de cepas do HBV com mutações de resistência aos análogos nucleos(t)ídeos (AN) utilizados no tratamento da… (more)

▼ O objetivo principal deste estudo foi avaliar a frequência de cepas do HBV com mutações de resistência aos análogos nucleos(t)ídeos (AN) utilizados no tratamento da hepatite B entre indivíduos cronicamente infectados, não submetidos a tratamento, procedentes de diferentes regiões do Brasil. Além disso, foram avaliadas a presença de mutações que alteram a antigenicidade do HBsAg promovendo escape dos anticorpos anti-HBs; mutações nos genes pré-core/core e a associação dos diferentes subgenótipos com as mutações encontradas e características demográficas e laboratoriais dos pacientes. Foram incluídas 779 amostras de soro de pacientes com infecção crônica pelo HBV e virgens de tratamento com AN ou interferon, as quais foram coletadas no período de 2006 a 2011. Os pacientes eram procedentes dos seguintes estados brasileiros: Pará, Maranhão, Bahia, Minas Gerais, São Paulo, Paraná e Rio Grande do Sul. O DNA do HBV foi extraído das amostras de soro utilizando o Kit QIAamp DNA Blood Mini Kit (Qiagen) e posteriormente foi realizada a amplificação das regiões S/polimerase (S/P) e pré-core/core (PCC) do genoma viral por nested PCR. O fragmento amplificado foi submetido a sequenciamento direto em sequenciador automático de DNA (ABI 3500) e as sequências obtidas foram analisadas para identificação dos genótipos e subgenótipos do HBV, pesquisa de mutações na polimerase, no HBsAg e nos genes pré-core/core. A região S/Pol foi amplificada e sequenciada com sucesso em 702 amostras, as quais foram incluídas para atender aos objetivos deste estudo. Entre as 702 amostras analisadas sete genótipos e 12 subgenótipos do HBV foram identificados. O subgenótipo A1 foi o mais frequente (63,7%, 447/702), seguido pelo HBV/D3 (14,5%, 102/702). Os demais genótipos e subgenótipos encontrados e suas frequências foram as seguintes: A2 (3,3%, 23/702), A3 (0,1%, 1/702), B1 (0,1%, 1/702), B2 (0,1%, 1/702), C2 (0,9%, 6/702), D1 (0,9%, 6/702), D2 (4,6%, 32/702), D4 (5,1%, 36/702), D com subgenótipo não identificado (0,7%, 5/702), E (0,6%, 4/702), F2a (4,6%, 32/702), F4 (0,4%, 3/702), e G (0,4%, 3/702). Cepas do HBV com mutações de resistência (rtS202G, rtM204V/I, rtA194T, rtM250I, rtA181T/S, rtT184S) associadas ou não a mutações compensatórias (rtL80I, rtV173L, rtL180M, rtV207I) foram identificadas em 1,6% (11/702) das amostras analisadas. Cepas com mutações potencialmente associadas com resistência ao adefovir (rtS85A, rtL217R, rtI233V, rtN238T, rtN238D, rtN248H, rtV214A,e rtQ215S) ou ao entecavir (rtS219A) foram identificadas em 7,7% (54/702) e 2,6% (16/702) dos pacientes, respectivamente. Cinquenta e sete (8,5%) amostras apresentaram cepas do HBV com mutações na principal região hidrofílica do HBsAg previamente relacionadas com escape dos anticorpos anti-HBs ou com prejuízo na secreção do HBsAg. Foram feitas análises estatísticas para avaliar a correlação entre os subgenótipos do HBV mais frequentes na casuística (A1, A2, D1, D2, D3, D4 e F2a) e a presença de mutações nos genes PCC. Dentre as mutações nos genes PCC associadas com redução ou falha na… Advisors/Committee Members: Corrêa, Maria Cassia Jacintho Mendes, Pinho, João Renato Rebello.

Subjects/Keywords: Antivirais; Antivirals; Chronic hepatitis B/epidemiology; Diagnósticos moleculares; Drug resistance; Genótipo; Genotype; Hepatite B crônica/epidemiologia; Hepatitis B vírus; Molecular diagnosis; Mutação; Mutation; Resistência a medicamentos; Vírus da hepatite B

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gouvêa, M. S. G. (2014). Prevalência de resistência primária aos antivirais utilizados no tratamento da hepatite B entre pacientes com infecção crônica pelo vírus da hepatite B não submetidos a tratamento. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5168/tde-04092014-163442/ ;

Chicago Manual of Style (16^th Edition):

Gouvêa, Michele Soares Gomes. “Prevalência de resistência primária aos antivirais utilizados no tratamento da hepatite B entre pacientes com infecção crônica pelo vírus da hepatite B não submetidos a tratamento.” 2014. Doctoral Dissertation, University of São Paulo. Accessed January 15, 2021. http://www.teses.usp.br/teses/disponiveis/5/5168/tde-04092014-163442/ ;.

MLA Handbook (7^th Edition):

Gouvêa, Michele Soares Gomes. “Prevalência de resistência primária aos antivirais utilizados no tratamento da hepatite B entre pacientes com infecção crônica pelo vírus da hepatite B não submetidos a tratamento.” 2014. Web. 15 Jan 2021.

Vancouver:

Gouvêa MSG. Prevalência de resistência primária aos antivirais utilizados no tratamento da hepatite B entre pacientes com infecção crônica pelo vírus da hepatite B não submetidos a tratamento. [Internet] [Doctoral dissertation]. University of São Paulo; 2014. [cited 2021 Jan 15]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5168/tde-04092014-163442/ ;.

Council of Science Editors:

Gouvêa MSG. Prevalência de resistência primária aos antivirais utilizados no tratamento da hepatite B entre pacientes com infecção crônica pelo vírus da hepatite B não submetidos a tratamento. [Doctoral Dissertation]. University of São Paulo; 2014. Available from: http://www.teses.usp.br/teses/disponiveis/5/5168/tde-04092014-163442/ ;

29. Hirota, Silvio Kenji. Líquen plano oral: atiopatogenia. Transtornos de ansiedade e depressão e uso de medicamentos.

Degree: PhD, Diagnóstico Bucal, 2007, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/23/23139/tde-11042008-124535/ ;

►

Este estudo teve por objetivo investigar a associação transtornos de ansiedade e depressão e do uso de medicamentos com o líquen plano oral (LPO). O… (more)

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Este estudo teve por objetivo investigar a associação transtornos de ansiedade e depressão e do uso de medicamentos com o líquen plano oral (LPO). O grupo de estudo compreendeu pacientes com diagnóstico clínico e histopatológico de LPO, segundo critérios da Organização Mundial de Saúde (WHO, 1978), com ou sem envolvimento cutâneo ou de outras mucosas. Um grupo controle composto por indivíduos sem lesão de líquen plano cutâneo e/ou mucoso, com perfil semelhante ao dos pacientes com LPO em relação ao sexo, idade e cor, foi incluído. Para avaliação de transtornos de ansiedade e depressão foram aplicadas duas escalas de auto-avaliação, respectivamente, o Inventário de Ansiedade Traço-Estado (IDATE-T) e a Escala de Rastreamento Populacional para Depressão - Center for Epidemiologic Studies Depression Scale (CES-D), ambas as escalas validadas internacionalmente. O uso diário de medicamentos foi analisado de acordo com os seguintes critérios: (1) classificação de medicamentos de acordo com o código ATC (Anatomical Therapeutic Chemical - classificação pela OMS, versão 2007), (2) quantidade de medicamentos utilizados - monofarmacia: 1 medicamento, polifarmacia menor: 2 a 4 medicamentos, e polifarmacia maior: 5 ou mais medicamentos, e (3) uso de medicamentos com potencial de induzir reação liquenóide a drogas. Sessenta e três pacientes LPO (média de idade = 54,2 anos, relação mulher/homem 6:1) e 35 do grupo controle (média de idade = 53,3 anos, relação mulher/homem 4:1) compuseram a casuística de pacientes avaliados. Os resultados demonstraram que não houve diferenças estatisticamente significantes (P > 0,05) entre o grupo LPO e o grupo controle com relação aos transtornos de ansiedade e depressão e o uso de medicamentos. Em conclusão, transtornos de ansiedade e depressão e o uso de medicamentos parecem não constituir fatores diretos na etiopatogenia do LPO. Todavia, esses fatores devem ser considerados na avaliação geral do paciente LPO, principalmente em termos de tratamento da lesão oral.

This study was aimed at investigating the possible association of the anxiety and depression disorders and the use of drugs with the oral lichen planus (OLP). The study group included patients with clinical and histopathologic diagnosis of OLP, according World Health Organization criteria (WHO, 1978), with or without skin and others mucosal involvement. A control group composed of individuals without skin and/or mucosal lichen planus, with similar characteristics to the OLP patients in respect to the sex, age and skin color, was included. For evaluation of anxiety and depression disorders a two self-administered scale the State-Trait Anxiety Inventory (STAI-T) and the Center for Epidemiologic Studies Depression Scale (CES-D) scales were applied, both internationally validated scales. The daily drug intake was analyzed according to the following criteria: (1) classification of drugs according the ATC code (Anatomical Therapeutic Chemical - classification by OMS, 2007 version), (2) amount of drugs used - monopharmacy: 1 drug, minor…

Advisors/Committee Members: Migliari, Dante Antonio.

Subjects/Keywords: Depressão; Depression; Diagnosis Lichen Planus Oral; Diagnóstico bucal; Lichen Planus Oral; Líquen plano bucal; Medicamento; Oral Anxiety Disorders; Oral Drug Use; Transtornos da ansiedade

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hirota, S. K. (2007). Líquen plano oral: atiopatogenia. Transtornos de ansiedade e depressão e uso de medicamentos. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/23/23139/tde-11042008-124535/ ;

Chicago Manual of Style (16^th Edition):

Hirota, Silvio Kenji. “Líquen plano oral: atiopatogenia. Transtornos de ansiedade e depressão e uso de medicamentos.” 2007. Doctoral Dissertation, University of São Paulo. Accessed January 15, 2021. http://www.teses.usp.br/teses/disponiveis/23/23139/tde-11042008-124535/ ;.

MLA Handbook (7^th Edition):

Hirota, Silvio Kenji. “Líquen plano oral: atiopatogenia. Transtornos de ansiedade e depressão e uso de medicamentos.” 2007. Web. 15 Jan 2021.

Vancouver:

Hirota SK. Líquen plano oral: atiopatogenia. Transtornos de ansiedade e depressão e uso de medicamentos. [Internet] [Doctoral dissertation]. University of São Paulo; 2007. [cited 2021 Jan 15]. Available from: http://www.teses.usp.br/teses/disponiveis/23/23139/tde-11042008-124535/ ;.

Council of Science Editors:

Hirota SK. Líquen plano oral: atiopatogenia. Transtornos de ansiedade e depressão e uso de medicamentos. [Doctoral Dissertation]. University of São Paulo; 2007. Available from: http://www.teses.usp.br/teses/disponiveis/23/23139/tde-11042008-124535/ ;

University of Oulu

30. Koskinen, M. (Miika). Automatic assessment of functional suppression of the central nervous system due to propofol anesthetic infusion:from EEG phenomena to a quantitative index.

Degree: 2006, University of Oulu

URL: http://urn.fi/urn:isbn:9514281756

► Abstract The rationale for automatically monitoring anesthetic drug effects on the central nervous system (CNS) is to improve possibilities to gain objective information on a… (more)

▼ Abstract The rationale for automatically monitoring anesthetic drug effects on the central nervous system (CNS) is to improve possibilities to gain objective information on a patient's state and to adjust the medication individually. Although monitors have shown their usefulness in practice, there are still a number of unclear issues, especially with respect to the scientific foundations and validity of CNS monitoring techniques, and in monitoring the light hypnotic levels. Current monitors are, for example, often based on heuristics and ad hoc solutions. However, a quantitative index for anesthetic drug effect should have a sound relationship with observations and with the selected control variable. The research objectives are: (1) to explore propofol anesthetic related neurophysiological phenomena that can be applied in the automatic assessment of CNS suppression; (2) to develop a valid control variable for this purpose; (3) by means of digital signal processing and mathematical modeling, to design and to evaluate the performance of an index that correlates with the control variable. This dissertation introduces potentially useful neurophysiological phenomena, such as changes in phase synchronization between different EEG channels due to anesthesia, and painful stimulus evoked responses during the burst suppression. Furthermore, it refines the progression of the time-frequency patterns during the induction of anesthesia and shows their relation to the instant of unresponsiveness. The presented spontaneous and evoked EEG phenomena provide complementary information about the CNS functional suppression. Most significantly, the dissertation proposes a continuous and observation based control variable (r scale) and the means to predict its values by using EEG data. The definition of the scale provides a basis for anticipating the instant of the loss of consciousness. Additionally, the phase synchronization index as an indicator of drug effect is introduced. The approximate entropy descriptor performance is evaluated and optimised with a non-stationary signal recorded during the induction of anesthesia. The results open up opportunities to improve the preciseness, scientific validity and the interpretation of information on the anesthetic effects on CNS, and therefore, to increase the reliability of the anesthesia monitoring. Further work is needed to extend and verify the results in deep anesthesia.

Subjects/Keywords: algorithms; brain; diagnosis; drug effects; intravenous anesthetics; physiological monitoring; signal processing

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Koskinen, M. (. (2006). Automatic assessment of functional suppression of the central nervous system due to propofol anesthetic infusion:from EEG phenomena to a quantitative index. (Doctoral Dissertation). University of Oulu. Retrieved from http://urn.fi/urn:isbn:9514281756

Chicago Manual of Style (16^th Edition):

Koskinen, M (Miika). “Automatic assessment of functional suppression of the central nervous system due to propofol anesthetic infusion:from EEG phenomena to a quantitative index.” 2006. Doctoral Dissertation, University of Oulu. Accessed January 15, 2021. http://urn.fi/urn:isbn:9514281756.

MLA Handbook (7^th Edition):

Koskinen, M (Miika). “Automatic assessment of functional suppression of the central nervous system due to propofol anesthetic infusion:from EEG phenomena to a quantitative index.” 2006. Web. 15 Jan 2021.

Vancouver:

Koskinen M(. Automatic assessment of functional suppression of the central nervous system due to propofol anesthetic infusion:from EEG phenomena to a quantitative index. [Internet] [Doctoral dissertation]. University of Oulu; 2006. [cited 2021 Jan 15]. Available from: http://urn.fi/urn:isbn:9514281756.

Council of Science Editors:

Koskinen M(. Automatic assessment of functional suppression of the central nervous system due to propofol anesthetic infusion:from EEG phenomena to a quantitative index. [Doctoral Dissertation]. University of Oulu; 2006. Available from: http://urn.fi/urn:isbn:9514281756

Open Access Theses and Dissertations