subject:(PDI)

1. Rêgo, Alexandre Mário Duarte do. Estabilidade e estrutura das cadeias A e B da molécula de insulina.

Degree: 2013, RCAAP

URL: https://www.rcaap.pt/detail.jsp?id=oai:comum.rcaap.pt:10400.26/14116

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Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz

O presente trabalho de investigação baseia-se na hipótese das… (more)

Subjects/Keywords: Insulina; PDI; DLS; Estabilidade

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rêgo, A. M. D. d. (2013). Estabilidade e estrutura das cadeias A e B da molécula de insulina. (Thesis). RCAAP. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:comum.rcaap.pt:10400.26/14116

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rêgo, Alexandre Mário Duarte do. “Estabilidade e estrutura das cadeias A e B da molécula de insulina.” 2013. Thesis, RCAAP. Accessed March 05, 2021. https://www.rcaap.pt/detail.jsp?id=oai:comum.rcaap.pt:10400.26/14116.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rêgo, Alexandre Mário Duarte do. “Estabilidade e estrutura das cadeias A e B da molécula de insulina.” 2013. Web. 05 Mar 2021.

Vancouver:

Rêgo AMDd. Estabilidade e estrutura das cadeias A e B da molécula de insulina. [Internet] [Thesis]. RCAAP; 2013. [cited 2021 Mar 05]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:comum.rcaap.pt:10400.26/14116.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rêgo AMDd. Estabilidade e estrutura das cadeias A e B da molécula de insulina. [Thesis]. RCAAP; 2013. Available from: https://www.rcaap.pt/detail.jsp?id=oai:comum.rcaap.pt:10400.26/14116

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Edinburgh

2. Gray, Terry Allan. Structural and functional interrogation of Anterior Gradient-2.

Degree: PhD, 2013, University of Edinburgh

URL: http://hdl.handle.net/1842/8825

► Anterior Gradient-2 protein (AGR2) has recently been linked to the onset of several pathologies including asthma and inflammatory bowel disease. Most interestingly, it has been… (more)

▼ Anterior Gradient-2 protein (AGR2) has recently been linked to the onset of several pathologies including asthma and inflammatory bowel disease. Most interestingly, it has been discovered to influence the transformation of cells and metastatic growth essential to cancer development, and has subsequently been linked to the development of resistance to anti-cancer therapeutics. AGR2 protein is overexpressed in a diverse range of human cancer types, and has been detected secreted into the extracellular milieu. Thus, AGR2 protein represents a compelling pro-oncogenic signalling intermediate in tumour emergence and endurance. This thesis presents an interdisciplinary approach including structural biology, cell biology and synthetic biology, and clinical studies to shed more light on the role of AGR2 in cancer development. Synthetic cell based reagents were developed to define the dominant pathways that are reprogrammed in a cell as a result of AGR2 synthesis. A cell panel was engineered incorporating the AGR2 (and mutants thereof) allele into the AGR2-null A375 cell line. These tools were then coupled to quantitative proteomics (SILAC) to unravel the mechanism whereby introduction of AGR2 alters cell phenotype, allowing identification of dominant pathways affected by AGR2 signalling. Using pathway analysis tools, the dominant pathway suppressed by wt-AGR2 expression highlighted the p53-signalling axis. DNA damage induced p53 stabilisation and p21 induction by cisplatin treatment confirmed the influence of AGR2 gene expression. Further data analysis identified the outlying protein expression changes identified by SILAC was the anti-viral cell cycle regulator TSG101 (tumour susceptibility gene 101), and confirmed by immunoblotting. Transfection and silencing studies of TSG101 confirmed that TSG101 attenuates p53 function. These data provide a mechanism to explain the most dominant pathways reprogrammed by AGR2 expression, incorporating ER stress response, proliferation markers and p53 pathway attenuation. Further advances were made in analysis of the function, regulation, and drugability of AGR2 protein. Assays were devised to define the subunit structure of AGR2 as a dimer unit; subsequent functional studies defined intrinsically disordered motifs that regulate stability of the dimer. A two-site sandwich microtiter assay (2SMTA) was designed to screen for self-peptides and mutations that regulate oligomer stability. These assays were used to identify the first biochemical property of AGR2 being that the dimer unit is required for maximal binding to the AAA+ protein, and well characterised AGR2 interactor, Reptin. In addition, based on this dimeric structure, a novel solution based dimerisation assay was developed to identify natural products that are able to disrupt the dimer suggesting that AGR2 itself can be targeted in principle with small molecules for therapeutic purposes.

Subjects/Keywords: 616.99; Cancer; Metastasis; AGR2; PDI

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gray, T. A. (2013). Structural and functional interrogation of Anterior Gradient-2. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/8825

Chicago Manual of Style (16^th Edition):

Gray, Terry Allan. “Structural and functional interrogation of Anterior Gradient-2.” 2013. Doctoral Dissertation, University of Edinburgh. Accessed March 05, 2021. http://hdl.handle.net/1842/8825.

MLA Handbook (7^th Edition):

Gray, Terry Allan. “Structural and functional interrogation of Anterior Gradient-2.” 2013. Web. 05 Mar 2021.

Vancouver:

Gray TA. Structural and functional interrogation of Anterior Gradient-2. [Internet] [Doctoral dissertation]. University of Edinburgh; 2013. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1842/8825.

Council of Science Editors:

Gray TA. Structural and functional interrogation of Anterior Gradient-2. [Doctoral Dissertation]. University of Edinburgh; 2013. Available from: http://hdl.handle.net/1842/8825

University of Southern California

3. Sankar, Saranya. Discovery of small molecules for brain cancer treatment.

Degree: MS, Molecular Pharmacology and Toxicology, 2014, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/383014/rec/2033

► Brain tumor claimed the lives of 14,080 people in United States in the past year. Gliomas are one of the most malignant and deadly forms… (more)

Subjects/Keywords: brain cancer; tumor; PDI; glioblastomas

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sankar, S. (2014). Discovery of small molecules for brain cancer treatment. (Masters Thesis). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/383014/rec/2033

Chicago Manual of Style (16^th Edition):

Sankar, Saranya. “Discovery of small molecules for brain cancer treatment.” 2014. Masters Thesis, University of Southern California. Accessed March 05, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/383014/rec/2033.

MLA Handbook (7^th Edition):

Sankar, Saranya. “Discovery of small molecules for brain cancer treatment.” 2014. Web. 05 Mar 2021.

Vancouver:

Sankar S. Discovery of small molecules for brain cancer treatment. [Internet] [Masters thesis]. University of Southern California; 2014. [cited 2021 Mar 05]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/383014/rec/2033.

Council of Science Editors:

Sankar S. Discovery of small molecules for brain cancer treatment. [Masters Thesis]. University of Southern California; 2014. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/383014/rec/2033

University of Akron

4. Tian, Ding. Synthesis, Characterization and Thermal Analysis of Tetrahedral and Cyano-substituted Perylene-based Derivatives.

Degree: MS, Polymer Science, 2014, University of Akron

URL: http://rave.ohiolink.edu/etdc/view?acc_num=akron1407868184

► Perylene diimides (PDIs) have attracted the great interests of both academic and industrial people over decades of years because of their chemical stability, thermal stability,… (more)

Subjects/Keywords: Polymer Chemistry; perylene diimide; PDI

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tian, D. (2014). Synthesis, Characterization and Thermal Analysis of Tetrahedral and Cyano-substituted Perylene-based Derivatives. (Masters Thesis). University of Akron. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=akron1407868184

Chicago Manual of Style (16^th Edition):

Tian, Ding. “Synthesis, Characterization and Thermal Analysis of Tetrahedral and Cyano-substituted Perylene-based Derivatives.” 2014. Masters Thesis, University of Akron. Accessed March 05, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1407868184.

MLA Handbook (7^th Edition):

Tian, Ding. “Synthesis, Characterization and Thermal Analysis of Tetrahedral and Cyano-substituted Perylene-based Derivatives.” 2014. Web. 05 Mar 2021.

Vancouver:

Tian D. Synthesis, Characterization and Thermal Analysis of Tetrahedral and Cyano-substituted Perylene-based Derivatives. [Internet] [Masters thesis]. University of Akron; 2014. [cited 2021 Mar 05]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=akron1407868184.

Council of Science Editors:

Tian D. Synthesis, Characterization and Thermal Analysis of Tetrahedral and Cyano-substituted Perylene-based Derivatives. [Masters Thesis]. University of Akron; 2014. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=akron1407868184

University of Bristol

5. Apostolaki, Naomi. The evolution of pneumaticity in Sauropodomorpha and its correlation to body size.

Degree: PhD, 2018, University of Bristol

URL: https://research-information.bris.ac.uk/en/studentTheses/4cc35625-8bf5-42c0-a414-af202d357488 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.761119

► The superfamily Sauropodomorpha comprised some of the largest terrestrial herbivorous vertebrates that have ever walked on this planet. The study of these fascinating beings has… (more)

▼ The superfamily Sauropodomorpha comprised some of the largest terrestrial herbivorous vertebrates that have ever walked on this planet. The study of these fascinating beings has been at the forefront of palaeontological research throughout the years. Especially in the last 20 years, due to the advent of modern techniques and technologies, significant steps have been made towards our understanding of their physiology. One of the sauropodomorphs’ central morphological characteristics is the expression of postcranial skeletal pneumaticity (PSP), a condition that is also expressed in the other superfamily of the order Saurischia, the Theropoda, as well as in their extant relatives, the Avians. This condition remodels the vertebrae and, occasionally the girdles and appendicular elements, producing perforations, depressions, excavations, cavities and internal chambers. This is a result of bone invasion and resorption from the development of the lung-air sac diverticula of the respiratory system. The various forms of this expression have been addressed across all subfamilies of sauropodomorphs mostly from an evolutionary aspect and, recently, from a developmental scope too. The resulting hypotheses state that PSP may have acted as a mechanism for weight reduction, allowing for sauropods to attain large sizes without having to suffer analogous gravitational constraints from equally attained masses. Any possible associations, though, between the expression of pneumaticity and body size have not been put under test. Through this study, a method of quantification and categorisation of PSP, and therefore, classification of the sauropodomorphs which express it, is created from the data retrieved from 61 taxa across all subfamilies, permitting us not only to trace any correlation between PSP and metric size data (body mass and body length) but also to visualise the evolution of PSP throughout Sauropodomorpha. This classification scheme from highest to lowest expression of PSP, ‘Alpha’, ‘Beta’, ‘Gamma’, ‘Delta’, and ‘Epsilon’ stems from the numerical estimate of pneumaticity in terms of a percentage, called the Pneumaticity Degree Index (PDI%). The revised scheme, Pneumaticity Degree Index (PDI%), takes account of the number of vertebral elements that are pneumatized in a single vertebra, the nature of pneumaticity traits, as well as the intensity of pneumatization in different body regions of interest (e.g. vertebral column), resulting in an integral and comprehensive measure of PSP. The proposed method ranks each pneumaticity trait with a value from 1 to 5 with 1 (100%) representing the most invasive unambiguous trait (e.g. camellae) and 5 (~ 10%) the least invasive and most ambiguous trait (i.e. fossa). By adding and dividing by their number all of the observed traits of every available vertebra of a region we retrieve a decimal numeric outcome and this outcome is translated to a percentage. The total average pneumatization of any taxon is calculated by retrieving the total average of the pneumaticity from all available body…

Subjects/Keywords: 550; Sauropods; pneumaticity; PDI%; body size

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Apostolaki, N. (2018). The evolution of pneumaticity in Sauropodomorpha and its correlation to body size. (Doctoral Dissertation). University of Bristol. Retrieved from https://research-information.bris.ac.uk/en/studentTheses/4cc35625-8bf5-42c0-a414-af202d357488 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.761119

Chicago Manual of Style (16^th Edition):

Apostolaki, Naomi. “The evolution of pneumaticity in Sauropodomorpha and its correlation to body size.” 2018. Doctoral Dissertation, University of Bristol. Accessed March 05, 2021. https://research-information.bris.ac.uk/en/studentTheses/4cc35625-8bf5-42c0-a414-af202d357488 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.761119.

MLA Handbook (7^th Edition):

Apostolaki, Naomi. “The evolution of pneumaticity in Sauropodomorpha and its correlation to body size.” 2018. Web. 05 Mar 2021.

Vancouver:

Apostolaki N. The evolution of pneumaticity in Sauropodomorpha and its correlation to body size. [Internet] [Doctoral dissertation]. University of Bristol; 2018. [cited 2021 Mar 05]. Available from: https://research-information.bris.ac.uk/en/studentTheses/4cc35625-8bf5-42c0-a414-af202d357488 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.761119.

Council of Science Editors:

Apostolaki N. The evolution of pneumaticity in Sauropodomorpha and its correlation to body size. [Doctoral Dissertation]. University of Bristol; 2018. Available from: https://research-information.bris.ac.uk/en/studentTheses/4cc35625-8bf5-42c0-a414-af202d357488 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.761119

6. MÁRCIO HOSOYA NAME. MÉTODO COMPUTACIONAL PARA AVALIAÇÃO DO CRESCIMENTO RADICULAR DA CULTURA DA SOJA.

Degree: 2013, UNIVERSIDADE ESTADUAL DE PONTA GROSSA

URL: http://www.bicen-tede.uepg.br/tde_busca/arquivo.php?codArquivo=1061

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A avaliação do sistema radicular é importante para melhor compreensão dos efeitos de manejo de nutrientes no solo e nutrição mineral de plantas. No entanto,… (more)

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A avaliação do sistema radicular é importante para melhor compreensão dos efeitos de manejo de nutrientes no solo e nutrição mineral de plantas. No entanto, essa avaliação tem sido uma atividade complexa, exaustiva e propícia a erros de amostragem e mensuração. Nesse contexto, o processamento digital de imagens e a análise de imagens podem auxiliar, pois têm sido utilizados em soluções de problemas similares. O objetivo deste trabalho foi desenvolver um método computacional para auxiliar na avaliação do crescimento radicular para amostras lavadas da cultura da soja, reduzindo o tempo gasto. Os resultados foram comparados com os métodos tradicionais (linha de interseção e massa fresca), e o software SAFIRA da Embrapa. O método proposto foi desenvolvido em plataforma Java, com aporte da biblioteca OpenCV por meio do plug-in JavaCV. A validação do método foi realizada comparando imagens (300 dpi) de amostras de fios de cobre de, 10, 20 e 50 mm de comprimento, com os valores obtidos manualmente com paquímetro, obtendo coeficientes de variação (CV) entre 0,01 e 2,99%. Das relações entre os comprimentos estimados com o método proposto e os obtidos pelo método tradicional obtiveram-se CVs variando entre 0,10 e 2,10%, que foram em média melhores que o SAFIRA (5,11% <CV <49,45%), em imagens de 300 dpi. O método também reduziu o tempo para obtenção dos atributos de raízes em mais de 53%. Dessa forma, o método proposto apresentou-se eficaz, principalmente para medidas de comprimento e área de amostras de raízes lavadas, sendo recomendado para estudos de raízes da cultura da soja.

The evaluation of the root system is important for better understanding of the effects of nutrient management on soil and plant mineral nutrition. However, this review has been a complex, comprehensive and conducive to sampling error and measurement activity. In this context, digital image processing and image analysis can help as they have been used in solutions of similar problems. The objective of this study was to develop a computational method to assist in the evaluation of root growth for washed samples of soybean, reducing the time spent. The results were compared with traditional methods (intersection line and fresh mass), and SAFIRA software Embrapa. The proposed method has been developed in Java platform with the OpenCV library supply through the plug-in JavaCV. The method validation was performed by comparing images (300 dpi) of samples of copper wires, 10, 20 and 50 mm in length, with values obtained manually using a caliper, obtaining coefficients of variation (CV) between 0.01 and 2.99%. Relations among the estimated lengths with the proposed method and those obtained by the traditional method yielded CVs ranging between 0.10 and 2.10 %, which were better than the average SAFIRA (5.11% <CV <49.45 %) at 300 dpi images. The method also reduced the time to obtain the attributes of roots in more than 53%. Thus, the proposed method showed to be effective, especially for measures of length and area samples are washed and is recommended for…

Advisors/Committee Members: Jeferson Zagonel, Adriel Ferreira da Fonseca, Rosane Falate, Ionildo José Sanches.

Subjects/Keywords: Sistema radicular; PDI; Glycine max L. (Merr.); Raiz; PDI; Root system; Glycine max L. (Merr.); Root; CIENCIA DA COMPUTACAO

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

NAME, M. H. (2013). MÉTODO COMPUTACIONAL PARA AVALIAÇÃO DO CRESCIMENTO RADICULAR DA CULTURA DA SOJA. (Thesis). UNIVERSIDADE ESTADUAL DE PONTA GROSSA. Retrieved from http://www.bicen-tede.uepg.br/tde_busca/arquivo.php?codArquivo=1061

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

NAME, MÁRCIO HOSOYA. “MÉTODO COMPUTACIONAL PARA AVALIAÇÃO DO CRESCIMENTO RADICULAR DA CULTURA DA SOJA.” 2013. Thesis, UNIVERSIDADE ESTADUAL DE PONTA GROSSA. Accessed March 05, 2021. http://www.bicen-tede.uepg.br/tde_busca/arquivo.php?codArquivo=1061.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

NAME, MÁRCIO HOSOYA. “MÉTODO COMPUTACIONAL PARA AVALIAÇÃO DO CRESCIMENTO RADICULAR DA CULTURA DA SOJA.” 2013. Web. 05 Mar 2021.

Vancouver:

NAME MH. MÉTODO COMPUTACIONAL PARA AVALIAÇÃO DO CRESCIMENTO RADICULAR DA CULTURA DA SOJA. [Internet] [Thesis]. UNIVERSIDADE ESTADUAL DE PONTA GROSSA; 2013. [cited 2021 Mar 05]. Available from: http://www.bicen-tede.uepg.br/tde_busca/arquivo.php?codArquivo=1061.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

NAME MH. MÉTODO COMPUTACIONAL PARA AVALIAÇÃO DO CRESCIMENTO RADICULAR DA CULTURA DA SOJA. [Thesis]. UNIVERSIDADE ESTADUAL DE PONTA GROSSA; 2013. Available from: http://www.bicen-tede.uepg.br/tde_busca/arquivo.php?codArquivo=1061

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Federal de Santa Maria

7. Ney Izaguirry de Freitas Junior. PROPOSTA DE METODOLOGIA DE IMPLANTAÇÃO DE PLANEJAMENTO ESTRATÉGICO COM O USO DAS DIMENSÕES DE UM SISTEMA DE AVALIAÇÃO SINAES: UM ESTUDO DE CASO.

Degree: 2009, Universidade Federal de Santa Maria

URL: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=2510

►

As mudanças ocorridas no mundo nos últimos anos vêm afetando de forma drástica pessoas, organizações e nações. Em uma velocidade crescente, são questionadas as bases… (more)

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As mudanças ocorridas no mundo nos últimos anos vêm afetando de forma drástica pessoas, organizações e nações. Em uma velocidade crescente, são questionadas as bases nas quais se construíram as teorias econômicas, sociais e políticas vigentes. Na tentativa de substituí-las criam-se novas teorias, que também se tornam ultrapassadas rapidamente. Diversos autores afirmam que a civilização humana atravessa um período de mudança de paradigma. As ciências relacionadas à gestão das empresas estão entre as mais afetadas por essa mudança. A era da Informação proporcionou uma crescente disponibilização de informações, e conseqüentemente uma melhoria educacional. Isto provocou uma crescente conscientização da população na cobrança por bens e serviços de qualidade, em todos os segmentos do setor público, inclusive no meio educacional. O Governo Federal em reconhecimento dessa nova realidade, através do artigo 37 da Ementa Constitucional n 19/98, realizou a inclusão na Constituição de Federal de 1998 a eficiência como princípio da Administração Pública. A partir dessa institucionalização surgiram outras normatizações como: a Lei Complementar no. 101/00, evocada de Lei de Responsabilidade Fiscal que determina práticas que resultem em maior eficiência na alocação e execução dos gastos públicos. Dessa forma o governo editou a lei no. 10.861/2004 que estabelece o Sistema Nacional de Avaliação Superior SINAES, que possui dez diretrizes que devem ser observadas por todas as Instituições de Ensino Superior para que obtenham o credenciamento ou descredenciamento junto ao MEC, portanto essas dimensões por serem vitais são estratégicas para as instituições de Ensino Superior, logo devem estar associadas ao planejamento estratégico, gerenciamento por diretrizes e consequentemente ao PDI das Instituições de Ensino Superior. Nesta perspectiva foi realizada uma pesquisa qualitativa, bibliográfica, descritiva de caráter exploratório, junto a Universidade Federal de Santa Maria UFSM na qual associou-se ao modelo de planejamento estratégico já existente as dimensões do SINAES. Sendo que essas dimensões são diretrizes fundamentais a qualquer IES foi realizado um desdobramento destas na instituição em estudo. Constatou-se que com o desdobramento dessas diretrizes o Gestor da UFSM possuir uma ferramenta administrativa essencial para a sua gestão.

In the last years, world changes have affected people, organizations and nations in a drastic way. In a growing speed, are questioned the bases in what economic, social and politic theories were constructed. In attempt of their substitution, new theories are created, that also become, quickly overshot. Many authors say human civilization goes through a period of paradigm change. The sciences related to companies management are the most affected by this change. Information Era provided a growing availability of information and consequently an educational improve. This caused a growing population conscious about goods and services quality demand in all public sectors, including educational means. Federal…

Advisors/Committee Members: Leoni Pentiado Godoy, Alberto Souza Schmidt, Clandia Maffini Gomes.

Subjects/Keywords: PDI e SINAES; gerenciamento por diretrizes; planejamento estratégico; ADMINISTRACAO; strategic projection; management for directives; PDI and SINAES

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Junior, N. I. d. F. (2009). PROPOSTA DE METODOLOGIA DE IMPLANTAÇÃO DE PLANEJAMENTO ESTRATÉGICO COM O USO DAS DIMENSÕES DE UM SISTEMA DE AVALIAÇÃO SINAES: UM ESTUDO DE CASO. (Thesis). Universidade Federal de Santa Maria. Retrieved from http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=2510

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Junior, Ney Izaguirry de Freitas. “PROPOSTA DE METODOLOGIA DE IMPLANTAÇÃO DE PLANEJAMENTO ESTRATÉGICO COM O USO DAS DIMENSÕES DE UM SISTEMA DE AVALIAÇÃO SINAES: UM ESTUDO DE CASO.” 2009. Thesis, Universidade Federal de Santa Maria. Accessed March 05, 2021. http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=2510.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Junior, Ney Izaguirry de Freitas. “PROPOSTA DE METODOLOGIA DE IMPLANTAÇÃO DE PLANEJAMENTO ESTRATÉGICO COM O USO DAS DIMENSÕES DE UM SISTEMA DE AVALIAÇÃO SINAES: UM ESTUDO DE CASO.” 2009. Web. 05 Mar 2021.

Vancouver:

Junior NIdF. PROPOSTA DE METODOLOGIA DE IMPLANTAÇÃO DE PLANEJAMENTO ESTRATÉGICO COM O USO DAS DIMENSÕES DE UM SISTEMA DE AVALIAÇÃO SINAES: UM ESTUDO DE CASO. [Internet] [Thesis]. Universidade Federal de Santa Maria; 2009. [cited 2021 Mar 05]. Available from: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=2510.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Junior NIdF. PROPOSTA DE METODOLOGIA DE IMPLANTAÇÃO DE PLANEJAMENTO ESTRATÉGICO COM O USO DAS DIMENSÕES DE UM SISTEMA DE AVALIAÇÃO SINAES: UM ESTUDO DE CASO. [Thesis]. Universidade Federal de Santa Maria; 2009. Available from: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=2510

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Pimentel, Sara Margarida Silva. Validação do Inventário de Ideação Delirante (PDI-21) para a População Portuguesa.

Degree: 2016, ISMT

URL: https://www.rcaap.pt/detail.jsp?id=oai:repositorio.ismt.pt:123456789/664

► Introdução: As abordagens dimensionais equacionam os delírios como situando-se num continuum com as crenças diárias, não estando circunscritos apenas à população clínica e podendo também… (more)

▼ Introdução: As abordagens dimensionais equacionam os delírios como situando-se num continuum com as crenças diárias, não estando circunscritos apenas à população clínica e podendo também ser encontrados na população geral. Devido à conceptualização multifacetada dos delírios, a análise das dimensões de desconforto, preocupação e convicção podem ser mais reveladoras do que o conteúdo da crença por si só, pelo que uma avaliação que incorpore estas dimensões é fundamental. Uma revisão de estudos mostrou uma lacuna de instrumentos para avaliar a ideação delirante na população geral, não existindo, no nosso conhecimento, nenhuma versão para a população portuguesa. Objetivos: Tradução, adaptação e estudo das propriedades psicométricas do Inventário de Ideação Delirante (PDI-21) para a população Portuguesa, com o intuito de avaliar a multidimensionalidade da ideação delirante na comunidade. Metodologia: A amostra é constituída por 249 adultos da população geral, com idades compreendidas entre 18 e 65 anos. Além do PDI-21, foi utilizado o Inventário de Sintomas Psicopatológicos (BSI), a subescala de Desejabilidade Social (DS) do Inventário de Personalidade de Eysenck – Forma Revista (EPQ-R) e o Instrumento de Avaliação da Qualidade de Vida da Organização Mundial de Saúde (WHOQOL-Bref). Resultados: A versão portuguesa do PDI-21 apresentou propriedades psicométricas adequadas no que respeita à sua consistência interna e estabilidade temporal. Demonstrou correlações positivas significativas com os sintomas psicopatológicos e associações negativas com a desejabilidade social e com a qualidade de vida, confirmando a sua validade convergente e divergente. A análise fatorial exploratória sugeriu a escala dicotómica do PDI ser constituída por um único fator. Por último, a análise da frequência de ideias delirantes (respostas positivas) para o total da amostra e em função do género revelou taxas de prevalência muito semelhantes às encontradas em estudos prévios. Discussão: A versão portuguesa do PDI-21 é caracterizada por propriedades psicométricas adequadas, podendo ser utilizada para avaliar a ideação delirante na população geral. Estudos futuros são necessários no sentido de replicar este estudo em populações mais jovens, bem como, comparar os resultados com uma amostra clínica. / Introduction: The dimensional approaches equate the delusions as placing themselves in a continuum with the daily beliefs, not being limited to the clinical population and it can also be found in the general population. Due to the delusions multifaceted conceptualization, the analysis of the dimensions of distress, preoccupation and conviction may be more revealing than the content of the belief by itself, whereby an evaluation that incorporates these dimensions is fundamental. A revision of studies has shown a gap of instruments to assess delusional ideation in the general population, not existing to our knowledge any version for the portuguese population. Objective: Translation, adaptation and study of the psychometric properties of the PDI-21 for the…

Subjects/Keywords: Avaliação - Assessment; Ideação delirante - Delusional ideation; Adultos - Adults; PDI - PDI; População não-clínica - Non-clinical population

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pimentel, S. M. S. (2016). Validação do Inventário de Ideação Delirante (PDI-21) para a População Portuguesa. (Thesis). ISMT. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:repositorio.ismt.pt:123456789/664

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pimentel, Sara Margarida Silva. “Validação do Inventário de Ideação Delirante (PDI-21) para a População Portuguesa.” 2016. Thesis, ISMT. Accessed March 05, 2021. https://www.rcaap.pt/detail.jsp?id=oai:repositorio.ismt.pt:123456789/664.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pimentel, Sara Margarida Silva. “Validação do Inventário de Ideação Delirante (PDI-21) para a População Portuguesa.” 2016. Web. 05 Mar 2021.

Vancouver:

Pimentel SMS. Validação do Inventário de Ideação Delirante (PDI-21) para a População Portuguesa. [Internet] [Thesis]. ISMT; 2016. [cited 2021 Mar 05]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:repositorio.ismt.pt:123456789/664.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pimentel SMS. Validação do Inventário de Ideação Delirante (PDI-21) para a População Portuguesa. [Thesis]. ISMT; 2016. Available from: https://www.rcaap.pt/detail.jsp?id=oai:repositorio.ismt.pt:123456789/664

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

9. BEZERRA, Jair de Lima. Estudo do Processo de Homogeneização do Boro Em Uma Bancada Experimental de Baixa Pressão Simulando o Pressurizador do Reator Iris .

Degree: 2012, Universidade Federal de Pernambuco

URL: http://repositorio.ufpe.br/handle/123456789/12459

► O controle da reatividade de um reator nuclear à água pressurizada é realizado pelo uso de barras de controle ou por diluição de boro na… (more)

Subjects/Keywords: Concentração de Boro; Controle de Reatividade; Processamento Digital de Imagens (PDI)

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APA (6^th Edition):

BEZERRA, J. d. L. (2012). Estudo do Processo de Homogeneização do Boro Em Uma Bancada Experimental de Baixa Pressão Simulando o Pressurizador do Reator Iris . (Thesis). Universidade Federal de Pernambuco. Retrieved from http://repositorio.ufpe.br/handle/123456789/12459

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

BEZERRA, Jair de Lima. “Estudo do Processo de Homogeneização do Boro Em Uma Bancada Experimental de Baixa Pressão Simulando o Pressurizador do Reator Iris .” 2012. Thesis, Universidade Federal de Pernambuco. Accessed March 05, 2021. http://repositorio.ufpe.br/handle/123456789/12459.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

BEZERRA, Jair de Lima. “Estudo do Processo de Homogeneização do Boro Em Uma Bancada Experimental de Baixa Pressão Simulando o Pressurizador do Reator Iris .” 2012. Web. 05 Mar 2021.

Vancouver:

BEZERRA JdL. Estudo do Processo de Homogeneização do Boro Em Uma Bancada Experimental de Baixa Pressão Simulando o Pressurizador do Reator Iris . [Internet] [Thesis]. Universidade Federal de Pernambuco; 2012. [cited 2021 Mar 05]. Available from: http://repositorio.ufpe.br/handle/123456789/12459.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

BEZERRA JdL. Estudo do Processo de Homogeneização do Boro Em Uma Bancada Experimental de Baixa Pressão Simulando o Pressurizador do Reator Iris . [Thesis]. Universidade Federal de Pernambuco; 2012. Available from: http://repositorio.ufpe.br/handle/123456789/12459

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

10. Dias, Sónia Marina Martins. Transição para a Vida Ativa de Jovens com Perturbação do Desenvolvimento Intelectual: A visão dos empregadores.

Degree: 2018, ESEPF

URL: https://www.rcaap.pt/detail.jsp?id=oai:repositorio.esepf.pt:20.500.11796/2700

►

A inclusão dos jovens com Perturbação do Desenvolvimento Intelectual (PDI) no mercado de trabalho não se processa de uma forma natural, como seria de esperar… (more)

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A inclusão dos jovens com Perturbação do Desenvolvimento Intelectual (PDI) no mercado de trabalho não se processa de uma forma natural, como seria de esperar numa sociedade inclusiva. Este estudo pretende recolher, analisar e determinar, sob a perspetiva dos empregadores, os fatores que facilitam ou dificultam a inserção profissional destes jovens. Pois é demarcando-os que se poderão equacionar e redefinir estratégias para que esta transição para a vida ativa das pessoas com PDI seja prática comum e cada vez mais uma realidade. Realizaram-se entrevistas semidiretivas, a sete orientadores do trabalho destes jovens, de empresas do distrito do Porto, inseridas numa cultura de trabalho em rede/parceria com um Centro de Educação e Formação Profissional (CEFP). A partir da análise dos dados e de uma abordagem qualitativa, trabalhámos com valores, atitudes e opiniões para desenvolver conceções, ideias e perceções acerca desta temática. Com base na análise dos dados, pudemos constatar que nas instituições visadas pelo nosso estudo, apesar de existirem ainda diversos fatores que não facilitam a transição para a vida ativa destes jovens, estes são superados pelos fatores que promovem este processo. Este estudo evidenciou, assim, a importância, na ótica das empresas, de fatores subjacentes ao sucesso da inserção profissional de jovens com PDI, da intervenção dos supervisores que incidem a sua prática na inserção social e profissional destes jovens, da sua formação com vista à aquisição de competências específicas no local de trabalho e da adaptação da tarefa ao perfil do jovem com PDI. Por outro lado, mostrou a necessidade de se rever e redefinir algumas políticas e práticas que, nesta perspetiva, não respondem às necessidades das pessoas com PDI face ao mercado de trabalho.

The inclusion of teenagers with Disruptive Intellectual Development in the labour market doesn’t work in a natural way, as it would be expected in an inclusive society. This study aims at collecting, analysing and determining, according to the employers’ view, the factors which facilitate or not, the professional inclusion of theses teens. It is by focusing on them that we can question and redefine the strategies so that these teens’ transition to the labour market would be a real common procedure. Semi-directing interviews were carried out with seven of these teens’ work supervisors, of companies from the district of Porto, inserted in a culture of networking/partnership with a Centre for Education and Vocational Training (CEFP). Based on data analysis and on a qualitative approach, we’ve worked with values, attitudes and opinions to develop concepts, ideas and perceptions about this issue. Based on the data’s analysis, we could verify that in the institutions targeted by our study, although there are still several factors that do not facilitate these youngsters’ transition to their active life, those factors are overcome by those that promote this process. This study points out the importance of the factors underlying the success of the…

Advisors/Committee Members: Afonso, Carlos, Medeiros, Paula.

Subjects/Keywords: Perturbação do Desenvolvimento Intelectual (PDI); Transição para a Vida Ativa

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dias, S. M. M. (2018). Transição para a Vida Ativa de Jovens com Perturbação do Desenvolvimento Intelectual: A visão dos empregadores. (Thesis). ESEPF. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:repositorio.esepf.pt:20.500.11796/2700

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dias, Sónia Marina Martins. “Transição para a Vida Ativa de Jovens com Perturbação do Desenvolvimento Intelectual: A visão dos empregadores.” 2018. Thesis, ESEPF. Accessed March 05, 2021. https://www.rcaap.pt/detail.jsp?id=oai:repositorio.esepf.pt:20.500.11796/2700.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dias, Sónia Marina Martins. “Transição para a Vida Ativa de Jovens com Perturbação do Desenvolvimento Intelectual: A visão dos empregadores.” 2018. Web. 05 Mar 2021.

Vancouver:

Dias SMM. Transição para a Vida Ativa de Jovens com Perturbação do Desenvolvimento Intelectual: A visão dos empregadores. [Internet] [Thesis]. ESEPF; 2018. [cited 2021 Mar 05]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:repositorio.esepf.pt:20.500.11796/2700.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dias SMM. Transição para a Vida Ativa de Jovens com Perturbação do Desenvolvimento Intelectual: A visão dos empregadores. [Thesis]. ESEPF; 2018. Available from: https://www.rcaap.pt/detail.jsp?id=oai:repositorio.esepf.pt:20.500.11796/2700

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington State University

11. [No author]. REGULATION, FUNCTION AND POTENTIAL APPLICATIONS OF MICROCIN PDI FOR MEDICINE AND FOOD SAFTEY .

Degree: 2018, Washington State University

URL: http://hdl.handle.net/2376/16390

► Microcin PDI (mccPDI) is a class IIa microcin that is encoded as a five-locus genetic unit that is borne by a conjugative plasmid. The microcin… (more)

▼ Microcin PDI (mccPDI) is a class IIa microcin that is encoded as a five-locus genetic unit that is borne by a conjugative plasmid. The microcin was first discovered in Escherichia coli strains 25 and 264 (cattle origin) and likely has a significant impact on the microbial composition of E. coli communities in livestock, even contributing to the persistence of antibiotic-resistant strains. This dissertation concerns the mechanism by which the mccPDI phenotype is regulated in the wild-type strains (Chapters 2), how the key effector protein (McpM) kills susceptible bacteria, and how the immunity protein (McpI) protects the mccPDI-producing bacteria (Chapter 3). Up-regulation of mccPDI is controlled by a two-component regulatory system (EnvZ/OmpR) that functions as an on/off switch. Low-salt conditions lead to upregulation of OmpR, which is a transcriptional regulator for both McpM and the cognate ligand on the susceptible cells, OmpF. Deletion of OmpR completely eliminates the mccPDI phenotype (Chapter 1). This on/off osmotic-sensing system is attenuated by the concentration of quorum sensing autoinducer-2 (AI-2) molecules in the culture media. Upregulation of mccPDI corresponds to increasing concentration of AI-2, while down regulation of the system corresponds to the decay of AI-2 as the bacterial population shifts from log-growth into stationary-growth phase. The kinetics of AI-2 expression correspond to the transcriptional pattern of mcpM, and deletion of the quorum sensing system eliminates upregulation of mcpM. It is very likely that sRNAs micC and micF also contribute to the mccPDI regulatory system (Chapter 2). A series of assays demonstrated that mccPDI inhibits the growth of susceptible bacteria when McpM permeabilizes the outer membrane, resulting in cell death. This phenotype can be blocked with the addition of low-molecular mass (200 – 600 Da) osmoprotectant to the culture media. The mechanism by which McpI protects mccPDI-producing cells is unknown, but experiments described in Chapter 3 show that McpI likely forms asymmetrical trimer structures that may serve to block pores that are formed by McpM. Advisors/Committee Members: Call, Douglas R (advisor).

Subjects/Keywords: Veterinary science; Antimicrobial peptide; Bacteriocin; MccPDI; Microcin; Microcin PDI; Quorum sensing

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

author], [. (2018). REGULATION, FUNCTION AND POTENTIAL APPLICATIONS OF MICROCIN PDI FOR MEDICINE AND FOOD SAFTEY . (Thesis). Washington State University. Retrieved from http://hdl.handle.net/2376/16390

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

author], [No. “REGULATION, FUNCTION AND POTENTIAL APPLICATIONS OF MICROCIN PDI FOR MEDICINE AND FOOD SAFTEY .” 2018. Thesis, Washington State University. Accessed March 05, 2021. http://hdl.handle.net/2376/16390.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

author], [No. “REGULATION, FUNCTION AND POTENTIAL APPLICATIONS OF MICROCIN PDI FOR MEDICINE AND FOOD SAFTEY .” 2018. Web. 05 Mar 2021.

Vancouver:

author] [. REGULATION, FUNCTION AND POTENTIAL APPLICATIONS OF MICROCIN PDI FOR MEDICINE AND FOOD SAFTEY . [Internet] [Thesis]. Washington State University; 2018. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/2376/16390.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

author] [. REGULATION, FUNCTION AND POTENTIAL APPLICATIONS OF MICROCIN PDI FOR MEDICINE AND FOOD SAFTEY . [Thesis]. Washington State University; 2018. Available from: http://hdl.handle.net/2376/16390

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. Frade, Kelly Stefany Tuna. Síntese de nitrosotióis para experimentação ex vivo e in vivo relacionada com a resistência à insulina.

Degree: 2013, RCAAP

URL: https://www.rcaap.pt/detail.jsp?id=oai:comum.rcaap.pt:10400.26/14152

►

Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz

O presente projeto de investigação pretende propor que a… (more)

▼

Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz

O presente projeto de investigação pretende propor que a Substância Hepática Sensibilizadora de Insulina (HISS) consiste num dos produtos de degradação da insulina (cadeia A/B) nitrosilados, e que a enzima interveniente na formação de tais produtos é a Proteína Dissulfito Isomerase (PDI) presente nos hepatócitos. Adicionalmente sugere-se a ligação dos nitrosilados de insulina à albumina. Com vista a tentar comprovar esta hipótese, a investigação efetuada teve o intuito de confirmar a existência de PDI ao nível dos hepatócitos, determinar a sua atividade e analisar os produtos de degradação originados. Outro dos objetivos foi efetuar a produção de nitrosotióis de cadeia A e B para posterior administração ex vivo e in vivo, e respetiva quantificação do potencial terapêutico. Neste sentido, foram realizados diversos ensaios. Assim, numa fase inicial procedeu-se à monitorização da degradação enzimática da insulina por via in vitro com recurso à PDI purificada e a lisados de hepatócitos de rato recorrendo à técnica de turbidimetria. Seguidamente, foi realizada a análise dos produtos originados pela degradação da insulina efetuada pela PDI purificada através de eletroforese SDS-PAGE. Posteriormente, procedeu-se à separação química da cadeia A e B da insulina com posterior produção de nitrosotióis. Por último, estes produtos foram administrados a miotubos de rato e a ratos Wistar e o seu potencial terapêutico quantificado através da medição da captação de 2-deoxi-glucose marcada com trítio radioativo e através de sucessivos testes RIST, respetivamente. Com efeito, os resultados desta investigação permitiram reforçar as ilações feitas pelos demais autores quanto à presença e atividade da PDI ao nível dos hepatócitos em relação à insulina, e para além disso confirmaram a suspeita inicial de que um dos derivados de insulina nitrosilados tem potencial efeito terapêutico ao nível da resistência à insulina apesar de não parecer estar relacionado com a estrutura da HISS.

Advisors/Committee Members: Caldeira, Francisco Jorge.

Subjects/Keywords: Cadeia A nitrosilada; Cadeia B nitrosilada; HISS; PDI

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Frade, K. S. T. (2013). Síntese de nitrosotióis para experimentação ex vivo e in vivo relacionada com a resistência à insulina. (Thesis). RCAAP. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:comum.rcaap.pt:10400.26/14152

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Frade, Kelly Stefany Tuna. “Síntese de nitrosotióis para experimentação ex vivo e in vivo relacionada com a resistência à insulina.” 2013. Thesis, RCAAP. Accessed March 05, 2021. https://www.rcaap.pt/detail.jsp?id=oai:comum.rcaap.pt:10400.26/14152.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Frade, Kelly Stefany Tuna. “Síntese de nitrosotióis para experimentação ex vivo e in vivo relacionada com a resistência à insulina.” 2013. Web. 05 Mar 2021.

Vancouver:

Frade KST. Síntese de nitrosotióis para experimentação ex vivo e in vivo relacionada com a resistência à insulina. [Internet] [Thesis]. RCAAP; 2013. [cited 2021 Mar 05]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:comum.rcaap.pt:10400.26/14152.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Frade KST. Síntese de nitrosotióis para experimentação ex vivo e in vivo relacionada com a resistência à insulina. [Thesis]. RCAAP; 2013. Available from: https://www.rcaap.pt/detail.jsp?id=oai:comum.rcaap.pt:10400.26/14152

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – San Francisco

13. Liu, Yi-Chang. The molecular basis of Htm1-mediated commitment of misfolded glycoproteins to endoplasmic reticulum-associated degradation.

Degree: Chemistry and Chemical Biology, 2016, University of California – San Francisco

URL: http://www.escholarship.org/uc/item/81v5f4tc

► In eukaryotes, nascent proteins that are destined for the secretory pathway enter the endoplasmic reticulum (ER) in unfolded states and generally leave only after they… (more)

▼ In eukaryotes, nascent proteins that are destined for the secretory pathway enter the endoplasmic reticulum (ER) in unfolded states and generally leave only after they have reached their native conformation. Protein folding in the ER is challenging and often error-prone. To prevent accumulation of misfolded proteins, the ER uses the ER-associated protein degradation (ERAD) machinery to detect and commit these defective proteins for retrotranslocation to cytosol for degradation via the ubiquitin-proteasome system. Previously, our group and others discovered an ERAD pathway that requires the generation of a specific N-glycan structure on misfolded luminal N-glycoproteins to permit their degradation. This N-glycan degradation signal can potentially serve as a mark to flag the defective states of the attached protein, but whether the generation of this N-glycan degradation signal is directly connected to the folding state of the attached protein has remained unknown.My thesis research work is focused on characterization of Htm1p, the mannosidase that is responsible for generating this N-glycan signal in Saccharomyces cerevisiae. Utilizing an in vitro reconstitution system of Htm1p in complex with its interacting partner, Pdi1p, and glycoprotein substrates whose structures can be closely manipulated, I find that unlike other members of the same mannosidase family, Htm1p-Pdi1p is a glycoprotein-specific mannosidase that has little activity against free glycan. I find that Htm1p-Pdi1p targets intrinsically and artificially misfolded proteins but not their native counterparts. Most importantly, I find that Htm1p-Pdi1p differentiates detailed folding states of misfolded proteins and preferentially acts on partially folded proteins to globally unfolded species. I further find that by forming a tight complex with Pdi1p, Htm1p blocks the intrinsic oxidoreductase function of Pdi1p but keeping the chaperone activity, suggesting a potential mechanism of how the Htm1p-Pdi1p complex recognizes misfolded proteins. In summary, this work demonstrates the tight correlation between the generation of the N-glycan degradation signal and the folding state of the attached protein, opening a future direction to investigate how the ER tells the bad from the good.

Subjects/Keywords: Biochemistry; ERAD; mannosidase; N-glycoprotein; PDI; protein quality control

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Liu, Y. (2016). The molecular basis of Htm1-mediated commitment of misfolded glycoproteins to endoplasmic reticulum-associated degradation. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/81v5f4tc

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Liu, Yi-Chang. “The molecular basis of Htm1-mediated commitment of misfolded glycoproteins to endoplasmic reticulum-associated degradation.” 2016. Thesis, University of California – San Francisco. Accessed March 05, 2021. http://www.escholarship.org/uc/item/81v5f4tc.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Liu, Yi-Chang. “The molecular basis of Htm1-mediated commitment of misfolded glycoproteins to endoplasmic reticulum-associated degradation.” 2016. Web. 05 Mar 2021.

Vancouver:

Liu Y. The molecular basis of Htm1-mediated commitment of misfolded glycoproteins to endoplasmic reticulum-associated degradation. [Internet] [Thesis]. University of California – San Francisco; 2016. [cited 2021 Mar 05]. Available from: http://www.escholarship.org/uc/item/81v5f4tc.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Liu Y. The molecular basis of Htm1-mediated commitment of misfolded glycoproteins to endoplasmic reticulum-associated degradation. [Thesis]. University of California – San Francisco; 2016. Available from: http://www.escholarship.org/uc/item/81v5f4tc

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Florida

14. Wang, Danxin. Spatial Allocation of Household Population at Parcel Level A Case Study of 2017 to 2040 Hillsborough County, Florida.

Degree: M.U.R.P, Urban and Regional Planning, 2018, University of Florida

URL: https://ufdc.ufl.edu/UFE0054087

► A Geographic Information System (GIS) based model is used to conduct the population allocation for Hillsborough County, Florida from 2017 to 2040. In the model,… (more)

Subjects/Keywords: allocation – cem – greenfield – infill – pdi – population – projection – redevelopment

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, D. (2018). Spatial Allocation of Household Population at Parcel Level A Case Study of 2017 to 2040 Hillsborough County, Florida. (Masters Thesis). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0054087

Chicago Manual of Style (16^th Edition):

Wang, Danxin. “Spatial Allocation of Household Population at Parcel Level A Case Study of 2017 to 2040 Hillsborough County, Florida.” 2018. Masters Thesis, University of Florida. Accessed March 05, 2021. https://ufdc.ufl.edu/UFE0054087.

MLA Handbook (7^th Edition):

Wang, Danxin. “Spatial Allocation of Household Population at Parcel Level A Case Study of 2017 to 2040 Hillsborough County, Florida.” 2018. Web. 05 Mar 2021.

Vancouver:

Wang D. Spatial Allocation of Household Population at Parcel Level A Case Study of 2017 to 2040 Hillsborough County, Florida. [Internet] [Masters thesis]. University of Florida; 2018. [cited 2021 Mar 05]. Available from: https://ufdc.ufl.edu/UFE0054087.

Council of Science Editors:

Wang D. Spatial Allocation of Household Population at Parcel Level A Case Study of 2017 to 2040 Hillsborough County, Florida. [Masters Thesis]. University of Florida; 2018. Available from: https://ufdc.ufl.edu/UFE0054087

15. -5585-894X. Aerosol measurement and mitigation in CO₂ capture by amine scrubbing.

Degree: PhD, Chemical Engineering, 2018, University of Texas – Austin

URL: http://hdl.handle.net/2152/67989

► Amine solvent losses are a significant issue for CO₂ capture by amine scrubbing. Solvent lost through aerosol emission represents an environmental hazard with adverse economic… (more)

▼ Amine solvent losses are a significant issue for CO₂ capture by amine scrubbing. Solvent lost through aerosol emission represents an environmental hazard with adverse economic implications. This research focuses on developing analytical systems to quantify amine aerosol emissions. Fourier Transform Infrared Spectrometry quantified amine emissions and Phase Doppler Interferometry determined aerosol size and concentration. Baghouse pretreatment of the flue gas significantly reduced amine emissions through collection of aerosol nuclei. A baghouse at the National Carbon Capture Center (NCCC) reduced monoethanolamine (MEA) emission by over a factor of 10. An SO₃ generator was built to facilitate bench and pilot scale aerosol experiments by reacting SO₂ in air over vanadium pentoxide catalyst at 520 °C. Aerosol generation at UT-SRP produced up to 1.7 grams per minute of SO₃, with conversion exceeding 81 %. Bench scale experiments achieved conversion greater than 97 % and aerosol concentration up to 7E4 cm⁻³. SO₃ increased piperazine (PZ) emission by up to 7.6 mol PZ/ mol SO₃. SO₂ increased PZ emission by 1 mol/ mol SO₂, and increased MEA emissions by 3.9 mol/ mol SO₂. H₂SO₄ increased PZ emission by 3 mol/ mol H₂SO₄. PZ resisted aerosol emissions with lower SO₃ content; this is because a low inlet aerosol nuclei concentration results in rapid aerosol growth and subsequent collection by impaction. Higher process temperatures correlated with decreasing PZ emission, supporting the growth and capture theory. Increasing the solvent PZ content was shown to strongly correlate with increasing PZ emission. In bench scale experiments, PZ emission and aerosol size both increased as the PZ content in the solvent increased. Lowering the temperature bulge stage reduced PZ emission and the aerosol size. Increasing the inlet CO₂ correlated with larger aerosol. Increasing the solvent CO₂ loading and the inlet SO₃ resulted in greater aerosol concentration. Operations with a blower upstream of the absorber increased MEA aerosol emission. The upstream blower resulted in larger aerosol in greater quantities, containing a greater quantity of MEA Reduced MEA emission with an intermediate blower are probably due to collection of aerosol through impaction within the blower. Advisors/Committee Members: Rochelle, Gary T. (advisor), Chen, Eric (committee member), Bonnecaze, Roger T (committee member), Hildebrant Ruiz, Lea (committee member), Knuutila, Hanna (committee member).

Subjects/Keywords: Amine aerosol; CO2 capture; Pilot plant; FTIR; PDI

10 more images…

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APA (6^th Edition):

-5585-894X. (2018). Aerosol measurement and mitigation in CO₂ capture by amine scrubbing. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/67989

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Chicago Manual of Style (16^th Edition):

-5585-894X. “Aerosol measurement and mitigation in CO₂ capture by amine scrubbing.” 2018. Doctoral Dissertation, University of Texas – Austin. Accessed March 05, 2021. http://hdl.handle.net/2152/67989.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

MLA Handbook (7^th Edition):

-5585-894X. “Aerosol measurement and mitigation in CO₂ capture by amine scrubbing.” 2018. Web. 05 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

-5585-894X. Aerosol measurement and mitigation in CO₂ capture by amine scrubbing. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2018. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/2152/67989.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Council of Science Editors:

-5585-894X. Aerosol measurement and mitigation in CO₂ capture by amine scrubbing. [Doctoral Dissertation]. University of Texas – Austin; 2018. Available from: http://hdl.handle.net/2152/67989

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

16. Patricio, Eliziane de Souza. Avaliação da interação do hidroperóxido de urato com a proteína dissulfeto isomerase (PDI) em processos inflamatórios.

Degree: Mestrado, Bioquímica, 2014, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/46/46131/tde-22012015-111631/ ;

►

A oxidação do ácido úrico (7,9-diidro-1H-purina-2,6,8(3H)-triona) pela mieloperoxidase (MPO) gera o radical de urato que, em presença do radical ânion superóxido combinam para formar o… (more)

▼

A oxidação do ácido úrico (7,9-diidro-1H-purina-2,6,8(3H)-triona) pela mieloperoxidase (MPO) gera o radical de urato que, em presença do radical ânion superóxido combinam para formar o hidroperóxido de urato (HOOU). Considerando os altos níveis de MPO, ácido úrico e superóxido na placa de ateroma espera-se que o ácido úrico seja oxidado a HOOU neste microambiente inflamatório. O HOOU é um oxidante mais forte que o peróxido de hidrogênio e pode oxidar grupos tiólicos de proteínas como a proteína dissulfeto isomerase (PDI). Como consequência à oxidação da PDI, ocorre uma modulação positiva sobre a NADPH oxidase (Nox) com aumento da produção de superóxido por neutrófilos. Sendo assim, a formação do HOOU no leito vascular poderia elucidar os mecanismos moleculares pelos quais o urato colabora para a progressão da aterosclerose em pacientes com hiperuricemia. Para investigar a interação do HOOU com a PDI, padronizou-se a síntese química do HOOU através de um sistema de fotooxidação do tipo I, utilizando urato, riboflavina (fotossensibilizador) e luz UVA. Inicialmente padronizou-se o tipo de irradiação e tempo de reação com o melhor rendimento para a síntese do HOOU. O HOOU formado e seu produto de redução o álcool 5-hidroxiisourato foram separados, identificados e caracterizados através de cromatografia liquida acoplada à espectrometria de massa (LC/MS). Após a purificação, determinou-se o coeficiente de absortividade molar em 308 nm (ε308 = 6537 ± 377 M-1.cm-1) e o tempo de meia-vida, aproximadamente 41 minutos à 22°C do HOOU. O HOOU foi capaz de reagir seletivamente com o aminoácido metionina e com o tripeptídeo glutationa. Além disso, o HOOU não forma adutos estáveis com a glutationa, sendo que toda glutationa consumida foi transformada em glutationa dissulfeto. Quando incubado com a PDI (10 µM), cerca de 70 e 100% do total de HOOU (3 µM) foi consumido após 30 e 120 segundos, respectivamente, enquanto que a PDI (23 µM) teve seus grupos tiólicos oxidados após a incubação com 140 µM HOOU por 30 min a 22°C. O HOOU oxidou os resíduos de cisteína dos dois sítios catalíticos da PDI com uma constante de velocidade da reação de 1,5 ± 0,04 x 103 M-1.s-1, demonstrando uma interação favorável com essa proteína no meio biológico e um possível papel modulatório do HOOU sobre a via PDI-Nox. Interessantemente, o ácido úrico aumentou a produção de superóxido e o consumo de oxigênio de células HL-60 diferenciadas em neutrófilos (dHL-60) e ativadas com acetato de miristato de forbol (PMA). Essa regulação poderia ser mediada através da formação do HOOU durante o \"burstöxidativo dos neutrófilos que oxidaria a enzima PDI induzindo um consequente aumento da atividade da Nox.

The oxidation of the uric acid (7,9-dihidro-1H-purine-2,6,8(3H)-trione) by myeloperoxidase (MPO) generates the urate radical. In inflammatory conditions the superoxide reacts with urate radical to form the urate hydroperoxide (HOOU). Taking into account the high amount of MPO, urate and superoxide in the atheroma…

Advisors/Committee Members: Meotti, Flavia Carla.

Subjects/Keywords: Ácido úrico (urato); Hidroperóxido de urato; Inflamação; Inflammation; Mieloperoxidase; Myeloperoxidase; Protein disulfide isomerase (PDI); Proteína dissulfeto isomerase (PDI); Urate hydroperoxide; Uric acid (urate)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Patricio, E. d. S. (2014). Avaliação da interação do hidroperóxido de urato com a proteína dissulfeto isomerase (PDI) em processos inflamatórios. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/46/46131/tde-22012015-111631/ ;

Chicago Manual of Style (16^th Edition):

Patricio, Eliziane de Souza. “Avaliação da interação do hidroperóxido de urato com a proteína dissulfeto isomerase (PDI) em processos inflamatórios.” 2014. Masters Thesis, University of São Paulo. Accessed March 05, 2021. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-22012015-111631/ ;.

MLA Handbook (7^th Edition):

Patricio, Eliziane de Souza. “Avaliação da interação do hidroperóxido de urato com a proteína dissulfeto isomerase (PDI) em processos inflamatórios.” 2014. Web. 05 Mar 2021.

Vancouver:

Patricio EdS. Avaliação da interação do hidroperóxido de urato com a proteína dissulfeto isomerase (PDI) em processos inflamatórios. [Internet] [Masters thesis]. University of São Paulo; 2014. [cited 2021 Mar 05]. Available from: http://www.teses.usp.br/teses/disponiveis/46/46131/tde-22012015-111631/ ;.

Council of Science Editors:

Patricio EdS. Avaliação da interação do hidroperóxido de urato com a proteína dissulfeto isomerase (PDI) em processos inflamatórios. [Masters Thesis]. University of São Paulo; 2014. Available from: http://www.teses.usp.br/teses/disponiveis/46/46131/tde-22012015-111631/ ;

17. Fukumasu, Newton Kiyoshi. Análise experimental da influência da frequência de injeção de combustível em chamas pulsadas de spray de etanol.

Degree: PhD, Engenharia Mecânica de Energia de Fluidos, 2014, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/3/3150/tde-26082015-104625/ ;

► E consenso que o crescente consumo de combustíveis fósseis na geração de potencia tem provocado uma maior degradação do meio ambiente. Para mitigar os efeitos… (more)

▼ E consenso que o crescente consumo de combustíveis fósseis na geração de potencia tem provocado uma maior degradação do meio ambiente. Para mitigar os efeitos adversos desse consumo, novas fontes e usos sustentáveis de energia são necessários. O uso de etanol na atual geração de motores de combustão interna demanda informações detalhadas sobre os processos de nebulização, evaporação, mistura e combustão das gotas desse combustível. Adicionalmente, novas estratégias de injeção de combustível em MCIs com injeção direta estão em desenvolvimento, como a injeção estraticada. Essa estratégia consiste na injeção de combustível em elevadas frequências durante as etapas de admissão e combustão do ciclo motor. Neste trabalho, técnicas avançadas de diagnostico a laser são utilizadas para analisar a inuência da frequência de injeção de combustível no processo de combustão de sprays pulsados de etanol, em que as chamas resultantes são estabilizadas por um swirler. A técnica de interferometria por efeito Doppler (PDI) foi utilizada para medir o diâmetro e a componente axial da velocidade das gotas. O campo de velocidades do escoamento de ar foi avaliado pela técnica de velocimetria por imagens de partículas (PIV) em duas taxas de aquisição (7,4 Hz e 2.000 Hz) para avaliar tanto valores médios quanto rastrear estruturas coerentes no escoamento. O mesmo sistema PIV foi utilizado para identificar a posição de aglomerados de gotas pela técnica de espalhamento Mie ao longo de eventos individuais de injeção. Já a técnica de uorescência induzida por laser do radical hidroxila (LIF-OH) foi utilizada com taxa de aquisição de 4.700 Hz para rastrear a região com presença deste radical próximo ao queimador utilizado. Imagens da luminescência química espontânea foram obtidas para observar características globais das chamas. O queimador, posicionado em um ambiente aberto, e composto por um dispositivo swirler e um injetor automotivo. As frequências de injeção de 100 Hz, 250 Hz e 400 Hz foram escolhidas para as análises por produzirem chamas com características que variam desde uma chama estável e ancorada ao queimador até o comportamento similar a uma chama suspensa e instável. Etanol anidro líquido foi utilizado como combustível e fornecido ao injetor a pressão e vazão constantes para todos os casos. Os resultados indicaram que a variação na frequência de injeção produziu sprays com diferentes densidades. A menor frequência de injeção produziu um spray com maior densidade, em que as gotas formaram um aglomerado pouco sensível ao escoamento de ar na linha de centro do queimador. Esse aglomerado produz uma chama ancorada ao queimador com formato alongado e estreito. Já a maior frequência de injeção produziu um spray com menor densidade, permitindo que a dinâmica das gotas seja mais susceptível ao escoamento de ar. Essa maior inuência do escoamento de ar promoveu uma maior dispersão espacial das gotas e um processo de combustão com maior susceptibilidade a instabilidades locais do escoamento. Essas instabilidades locais foram associadas a… Advisors/Committee Members: Krieger Filho, Guenther Carlos.

Subjects/Keywords: Combustão; Combustion; Etanol; Ethanol; Fluorescência Induzida por Laser (LIF); Interferometria por Efeito Doppler (PDI); Laser-induced Fluorescence (LIF); Phase Doppler Interferometry (PDI)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fukumasu, N. K. (2014). Análise experimental da influência da frequência de injeção de combustível em chamas pulsadas de spray de etanol. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/3/3150/tde-26082015-104625/ ;

Chicago Manual of Style (16^th Edition):

Fukumasu, Newton Kiyoshi. “Análise experimental da influência da frequência de injeção de combustível em chamas pulsadas de spray de etanol.” 2014. Doctoral Dissertation, University of São Paulo. Accessed March 05, 2021. http://www.teses.usp.br/teses/disponiveis/3/3150/tde-26082015-104625/ ;.

MLA Handbook (7^th Edition):

Fukumasu, Newton Kiyoshi. “Análise experimental da influência da frequência de injeção de combustível em chamas pulsadas de spray de etanol.” 2014. Web. 05 Mar 2021.

Vancouver:

Fukumasu NK. Análise experimental da influência da frequência de injeção de combustível em chamas pulsadas de spray de etanol. [Internet] [Doctoral dissertation]. University of São Paulo; 2014. [cited 2021 Mar 05]. Available from: http://www.teses.usp.br/teses/disponiveis/3/3150/tde-26082015-104625/ ;.

Council of Science Editors:

Fukumasu NK. Análise experimental da influência da frequência de injeção de combustível em chamas pulsadas de spray de etanol. [Doctoral Dissertation]. University of São Paulo; 2014. Available from: http://www.teses.usp.br/teses/disponiveis/3/3150/tde-26082015-104625/ ;

Universidade do Rio Grande do Sul

18. Silva, Everson Pinto da. Processo de planejamento estratégico em universidades : um modelo para IFES.

Degree: 2015, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/127807

►

O ensino superior é considerado, atualmente, o precursor do desenvolvimento econômico e social dos países. Para desempenhar esse papel, as universidades têm buscado novas formas… (more)

▼

O ensino superior é considerado, atualmente, o precursor do desenvolvimento econômico e social dos países. Para desempenhar esse papel, as universidades têm buscado novas formas de gestão. Para auxiliá-las nesta missão, o planejamento estratégico tornou-se uma ferramenta importante neste sentido, utilizado tanto em instituições privadas quanto em públicas. As Instituições Federais de Ensino Superior (IFES) possuem o planejamento elaborado por meio de um modelo de Plano de Desenvolvimento Institucional (PDI) proposto pelo governo. No entanto, apesar dessa estrutura ser considerada como o planejamento estratégico, as universidades não se apropriam desse formato. Nesse cenário, as IFES carecem de um processo de planejamento que contemple as suas características. Dado isso, o objetivo desta dissertação é propor um modelo de processo de planejamento estratégico para IFES. Para atingir o objetivo, foram desenvolvidos três artigos. No primeiro artigo, foi elaborada uma revisão da literatura a fim de responder questões que embasem a proposição do modelo, enquanto no segundo artigo foi realizada uma análise documental acerca de PDIs e de Planos de Gestão (PGs) das IFES, a partir da qual foram identificados o relacionamento entre estes planos e as possíveis influências das variáveis no processo de planejamento sob as constatações detectadas na análise. Por fim, no terceiro artigo foi proposto o modelo de processo de planejamento completo, através de um estudo de caso com grupos focados aplicado em uma IFES. Como conclusão geral, identificaram-se elementos estratégicos que foram propostos com mais frequência em universidades. Confirmou-se que o modelo proposto pelo governo não atende a estas universidades, e verificou-se que os planos utilizados nas IFES não possuem elementos estratégicos. Além disso, identificaram-se as variáveis que podem influenciar o processo de planejamento estratégico e suas possíveis influências no caso em estudo. Por fim, propôs-se um modelo de processo de planejamento adaptado ao contexto das IFES, além das dinâmicas que podem ser utilizadas em cada fase desse processo.

Higher education is, nowadays, considered the precursor of economic and social development of the countries. To play this role, universities have been seeking new forms of management. To help them in this mission, the strategic planning has become a important tool in this sense, used in both private and public enterprises. The Brazilian public universities, particularly the federal ones, IFES, already have their planning drawn up by an Institutional Development Plan model (PDI) proposed by the government. However, despite this structure have been considered strategic planning, universities do not appropriated of this format. In this scenario, the IFES lack of a planning process that incorporates their characteristics. Given this, the aim of this work is to propose a strategic planning process model for IFES. To achieve this goal, we have developed three articles. In the first article, a literature review was undertaken to answer…

Advisors/Committee Members: Ten Caten, Carla Schwengber.

Subjects/Keywords: Strategic planning; Planejamento estratégico; Instituições de ensino superior; Model; Elements; IFES; PDI

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Silva, E. P. d. (2015). Processo de planejamento estratégico em universidades : um modelo para IFES. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/127807

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Silva, Everson Pinto da. “Processo de planejamento estratégico em universidades : um modelo para IFES.” 2015. Thesis, Universidade do Rio Grande do Sul. Accessed March 05, 2021. http://hdl.handle.net/10183/127807.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Silva, Everson Pinto da. “Processo de planejamento estratégico em universidades : um modelo para IFES.” 2015. Web. 05 Mar 2021.

Vancouver:

Silva EPd. Processo de planejamento estratégico em universidades : um modelo para IFES. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2015. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10183/127807.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Silva EPd. Processo de planejamento estratégico em universidades : um modelo para IFES. [Thesis]. Universidade do Rio Grande do Sul; 2015. Available from: http://hdl.handle.net/10183/127807

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Nara Vidal Pantoja. Técnicas de processamento de imagens digitais para detecção de feições associadas ao corte seletivo de madeira na Amazônia.

Degree: 2010, Instituto Nacional de Pesquisas Espaciais

URL: http://urlib.net/sid.inpe.br/mtc-m19/2010/08.31.20.11

►

A exploração florestal tem afetado extensas áreas de florestas primárias na Amazônia brasileira. Esta atividade, quando praticada com base no manejo florestal, pode ser uma… (more)

▼

A exploração florestal tem afetado extensas áreas de florestas primárias na Amazônia brasileira. Esta atividade, quando praticada com base no manejo florestal, pode ser uma grande aliada no esforço para reduzir o desmatamento na região. O monitoramento florestal é fundamental para estabelecer planos de ação e estratégias que contribuam para o uso sustentável dos recursos naturais. Considerando a extensão da área sob exploração madeireira, a tecnologia de sensoriamento remoto orbital oferece meios para otimização do monitoramento. Neste contexto, este estudo realizado no norte do Mato Grosso analisou imagens de alta resolução espacial para caracterizar a geometria e o contraste radiométrico das feições mais conspícuas da atividade madeireira, que são os pátios de estocagem de madeira. Tamanho, forma dos pátios, distância entre eles e o contraste radiométrico entre pátios e a floresta em seu entorno foram caracterizados para fundamentar o desenvolvimento de um algoritmo de detecção de alvos pontuais a partir de técnicas de processamento de imagens aplicadas a dados de resolução espacial média. Foi realizada uma análise exploratória das imagens de alta resolução HRC/CBERS-2B para descrever características radiométricas e geométricas de pátios de estocagem e para avaliar sua utilidade como verdade terrestre para estudos relacionados ao monitoramento da exploração madeireira. Investigou-se a aplicação de modelo linear de mistura espectral, NDVI e transformações por IHS e principais componentes em imagens TM/LANDSAT e CCD/CBERS para detectar atividade de corte seletivo de madeira e foi desenvolvido um método para detectar pátios baseando-se no contexto da vizinhança dos pátios. Os resultados mostraram que os pátios têm brilho medido pela HRC 57% maior do que a floresta e apresentaram área média de 380 m² distribuídos numa distância de em média 460 metros. Deste modo, em imagens de resolução de 20 a 30 metros (400 a 900 m²), os pátios se apresentam como objetos pontuais, o que justifica a proposição do uso de contexto de vizinhança para sua detecção. Foi definido limiar de decisão para definição do objeto "pátio"para cada imagem analisada e um algoritmo desenvolvido a partir da decisão de um "pátio"como um pixel de valor acima ou abaixo do limiar envolto de pixels com média abaixo ou acima deste limiar, dependendo da imagem analisada. A comparação das imagens antes e após a aplicação da metodologia proposta permitiu identificar áreas com ocorrência de exploração madeireira evidenciada a partir do realce de pátios de estocagem. Na análise de exatidão baseada na verdade terrestre derivada dos dados HRC 54% a 75% foram corretamente identificados pelas diferentes técnicas.

Extensive areas of primary forest have been impacted by logging in the Brazilian Amazon Region. This activity, when conducted based on forest management, may be a great aid in the effort to reduce regional deforestation. Forest monitoring is fundamental for the establishment of action plans and strategies that contribute to the sustainable use of…

Advisors/Committee Members: Flávio Jorge Ponzoni, João Vianei Soares, Dalton de Morisson Valeriano, Yosio Edemir Shimabukuro, Eraldo Aparecido Trondoli Matricardi.

Subjects/Keywords: Amazônia; corte seletivo; Processamento Digital de Imagens (PDI); Amazon; selective logging; Digital Image Processing (DIP)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pantoja, N. V. (2010). Técnicas de processamento de imagens digitais para detecção de feições associadas ao corte seletivo de madeira na Amazônia. (Thesis). Instituto Nacional de Pesquisas Espaciais. Retrieved from http://urlib.net/sid.inpe.br/mtc-m19/2010/08.31.20.11

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pantoja, Nara Vidal. “Técnicas de processamento de imagens digitais para detecção de feições associadas ao corte seletivo de madeira na Amazônia.” 2010. Thesis, Instituto Nacional de Pesquisas Espaciais. Accessed March 05, 2021. http://urlib.net/sid.inpe.br/mtc-m19/2010/08.31.20.11.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pantoja, Nara Vidal. “Técnicas de processamento de imagens digitais para detecção de feições associadas ao corte seletivo de madeira na Amazônia.” 2010. Web. 05 Mar 2021.

Vancouver:

Pantoja NV. Técnicas de processamento de imagens digitais para detecção de feições associadas ao corte seletivo de madeira na Amazônia. [Internet] [Thesis]. Instituto Nacional de Pesquisas Espaciais; 2010. [cited 2021 Mar 05]. Available from: http://urlib.net/sid.inpe.br/mtc-m19/2010/08.31.20.11.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pantoja NV. Técnicas de processamento de imagens digitais para detecção de feições associadas ao corte seletivo de madeira na Amazônia. [Thesis]. Instituto Nacional de Pesquisas Espaciais; 2010. Available from: http://urlib.net/sid.inpe.br/mtc-m19/2010/08.31.20.11

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Leiden University

20. Bezemer, Jenneke. The role of maternal reflective functioning on child mentalizing and child aggression: the influence of coaching.

Degree: 2015, Leiden University

URL: http://hdl.handle.net/1887/35538

► Objective To examine the relationship between maternal reflective functioning (RF) and child aggression and whether this relationship is mediated by child’s precursors of Theory of… (more)

▼ Objective To examine the relationship between maternal reflective functioning (RF) and child aggression and whether this relationship is mediated by child’s precursors of Theory of Mind (ToM). The influence of coaching on maternal reflective functioning and child aggression is also examined. Method The sample consisted of 85 mother-infant dyads. Mothers were allocated to a high or low risk group based on maternal characteristics. Half of the high risk mothers were randomly assigned to a coaching group. Maternal reflective functioning was assessed prenatally and when children were 20 months of age by Pregnancy Interview (PI) and Parental Development Interview (PDI). Mothers were asked to aggressive symptoms in their child. Children’s precursors of ToM were measured at 20 months by an imitation task, a visual perspectives task and a discrepant desires task. Results Maternal prenatal reflective functioning was found to be negatively related to child aggressive behaviour. However maternal postnatal self-related RF was positively related to child aggression. In addition, maternal reflective functioning was found to be positively related to one precursor of ToM, but ToM did not mediate the relationship between maternal reflective functioning and child aggression. No effect of coaching on maternal reflective functioning and child aggression was found. Conclusion The present study provides evidence for the relationship between maternal reflective functioning and child aggression at a young age. This emphasizes the importance of well-developed maternal reflective functioning capacities for the behavioural development of children. This relationship could be mediated by child’s ToM, but this should be further researched. Coaching would be a suitable way to enhance maternal reflective functioning capacities, but the effects of coaching should be investigated after mothers received coaching for a longer period of time. Advisors/Committee Members: Huijbregts, Stephan (advisor).

Subjects/Keywords: maternal reflective functioning; PI; PDI; child psychopathology; child aggression; child mentalizing; Theory of Mind; coaching

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APA (6^th Edition):

Bezemer, J. (2015). The role of maternal reflective functioning on child mentalizing and child aggression: the influence of coaching. (Masters Thesis). Leiden University. Retrieved from http://hdl.handle.net/1887/35538

Chicago Manual of Style (16^th Edition):

Bezemer, Jenneke. “The role of maternal reflective functioning on child mentalizing and child aggression: the influence of coaching.” 2015. Masters Thesis, Leiden University. Accessed March 05, 2021. http://hdl.handle.net/1887/35538.

MLA Handbook (7^th Edition):

Bezemer, Jenneke. “The role of maternal reflective functioning on child mentalizing and child aggression: the influence of coaching.” 2015. Web. 05 Mar 2021.

Vancouver:

Bezemer J. The role of maternal reflective functioning on child mentalizing and child aggression: the influence of coaching. [Internet] [Masters thesis]. Leiden University; 2015. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1887/35538.

Council of Science Editors:

Bezemer J. The role of maternal reflective functioning on child mentalizing and child aggression: the influence of coaching. [Masters Thesis]. Leiden University; 2015. Available from: http://hdl.handle.net/1887/35538

Queens University

21. Musterer, Namamrta. Perylene Diimide Molecular Glass: Investigations of Charge Transport .

Degree: Physics, Engineering Physics and Astronomy, 2016, Queens University

URL: http://hdl.handle.net/1974/14682

► A new glass-forming organic semiconductor material was synthesized using a known electron transport material, perylene diimide, and attaching it to a molecular glass in order… (more)

Subjects/Keywords: traps ; Molecular glass ; mobility ; n-type organic semiconductor ; PDI ; CELIV ; electron transport ; perylene diimide

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APA (6^th Edition):

Musterer, N. (2016). Perylene Diimide Molecular Glass: Investigations of Charge Transport . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/14682

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Musterer, Namamrta. “Perylene Diimide Molecular Glass: Investigations of Charge Transport .” 2016. Thesis, Queens University. Accessed March 05, 2021. http://hdl.handle.net/1974/14682.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Musterer, Namamrta. “Perylene Diimide Molecular Glass: Investigations of Charge Transport .” 2016. Web. 05 Mar 2021.

Vancouver:

Musterer N. Perylene Diimide Molecular Glass: Investigations of Charge Transport . [Internet] [Thesis]. Queens University; 2016. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1974/14682.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Musterer N. Perylene Diimide Molecular Glass: Investigations of Charge Transport . [Thesis]. Queens University; 2016. Available from: http://hdl.handle.net/1974/14682

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manchester

22. Springate, Jennifer. The role of PDI and ERp46 in oxidative protein folding in the endoplasmic reticulum.

Degree: PhD, 2012, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-pdi-and-erp46-in-oxidative-protein-folding-in-the-endoplasmic-reticulum(0318ed57-52f0-47ef-afd5-60238e3cdca4).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553349

► Currently the mammalian endoplasmic reticulum (ER) is known to contain at least 20 different protein disulphide isomerase (PDI) family members. The oxidoreductases in the PDI… (more)

▼ Currently the mammalian endoplasmic reticulum (ER) is known to contain at least 20 different protein disulphide isomerase (PDI) family members. The oxidoreductases in the PDI family are thought to catalyse the formation and rearrangement of disulphide bonds in newly synthesised proteins. The focus of this work was to characterise two of the PDI family members: PDI and ERp46. In vitro translation reactions of major histocompatibility complex (MHC), β1-integrin (β1-I), haemagglutinin (HA), procollagen α1(III) and preprolaction (pPL) were carried out in untreated or PDI-depleted cells. The depletion of PDI decreased the rate of folding of MHC and β1-I and also prevented the oligomerisation of HA, suggesting a role for PDI in folding these putative substrates. However, when PDI was depleted neither the folding of pPL or HA was affected, implying that they may not be substrates for PDI. To determine the role of ERp46 in the cell, a substrate-trapping approach was used. Here substrates interacting with ERp46 were trapped as mixed disulphides isolated by immunoprecipitation, separated by 2D SDS-PAGE and identified by mass spectrometry. It was demonstrated that ERp46 forms mixed disulphides with at least 23 proteins, including heavily secreted proteins such as laminins, integrins and collagens. In particular, interactions with Ero1, Prx IV, EDEM3 and ERAP2 were found and confirmed by immunoprecipitation of radiolabelled in vitro translated protein. Notably nine of these clients of ERp46 have previously been identified as substrates of ERp57 (Jessop, Watkins et al. 2009). This would support the hypothesis that several different oxidoreductases, working in concert, are required to fold certain substrate proteins. Also, it was confirmed that Prx IV and Ero1 each form a mixed disulphide with PDI. These results highlight the importance of PDI family members in recruiting co-factors to substrates. Additionally, the over-expression of ERp46 led to increased cell survival following DTT treatment, yet after depletion of ERp46, cells were less able to grow, perhaps suggesting a role for ERp46 in maintaining ER redox homeostasis and cell survival. This suggestion was supported by the finding that ERp46 is able to catalyse the reduction of Prx IV in the presence of glutathione. These results suggest that Prx IV provides a novel mechanism for the transfer of disulphide bonds to nascent proteins in the ER via PDI family members such as ERp46 and PDI.

Subjects/Keywords: 571.65; protein disulphide isomerase; PDI; ERp46; folding; disulphide; disulfide; endoplasmic reticulum; oxidation; peroxiredoxin; Ero1

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APA (6^th Edition):

Springate, J. (2012). The role of PDI and ERp46 in oxidative protein folding in the endoplasmic reticulum. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-pdi-and-erp46-in-oxidative-protein-folding-in-the-endoplasmic-reticulum(0318ed57-52f0-47ef-afd5-60238e3cdca4).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553349

Chicago Manual of Style (16^th Edition):

Springate, Jennifer. “The role of PDI and ERp46 in oxidative protein folding in the endoplasmic reticulum.” 2012. Doctoral Dissertation, University of Manchester. Accessed March 05, 2021. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-pdi-and-erp46-in-oxidative-protein-folding-in-the-endoplasmic-reticulum(0318ed57-52f0-47ef-afd5-60238e3cdca4).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553349.

MLA Handbook (7^th Edition):

Springate, Jennifer. “The role of PDI and ERp46 in oxidative protein folding in the endoplasmic reticulum.” 2012. Web. 05 Mar 2021.

Vancouver:

Springate J. The role of PDI and ERp46 in oxidative protein folding in the endoplasmic reticulum. [Internet] [Doctoral dissertation]. University of Manchester; 2012. [cited 2021 Mar 05]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-pdi-and-erp46-in-oxidative-protein-folding-in-the-endoplasmic-reticulum(0318ed57-52f0-47ef-afd5-60238e3cdca4).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553349.

Council of Science Editors:

Springate J. The role of PDI and ERp46 in oxidative protein folding in the endoplasmic reticulum. [Doctoral Dissertation]. University of Manchester; 2012. Available from: https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-pdi-and-erp46-in-oxidative-protein-folding-in-the-endoplasmic-reticulum(0318ed57-52f0-47ef-afd5-60238e3cdca4).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553349

University of Gothenburg / Göteborgs Universitet

23. Tian, Fei. THE ANGIOGENIC RESPONSE IN HYPOXIC HEART. Experimental studies in mice.

Degree: 2009, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/19008

► Coronary artery disease is the leading cause of death in the western world today. Although induction of angiogenesis would appear to be an ideal therapeutic… (more)

▼ Coronary artery disease is the leading cause of death in the western world today. Although induction of angiogenesis would appear to be an ideal therapeutic strategy, clinical trials of proangiogenic factors have proved disappointing. Angiogenesis is a complex process involving many signaling pathways and mediators, and further insights into the underlying cellular and molecular mechanisms are urgently needed. Here, we used two mouse models, systemic hypoxia and myocardial infarction (MI), to study the effects of hypoxia on angiogenesis in the myocardium, and the cellular and molecular mechanisms involved. Hypoxia-inducible factor-1α (HIF-1α) is an important transcriptional regulator of angiogenesis. Small ubiquitin-related modifier-1 (SUMO-1) has been shown to stabilize transcription factors and modulate their activity. In our mouse model of systemic hypoxia, we showed that SUMO-1 expression is enhanced by hypoxia in brain and heart. Furthermore, SUMO-1 co-localizes and directly interacts with HIF-1α under hypoxic conditions, indicating that hypoxia-mediated increases in SUMO-1 expression could modulate HIF-1α function. We combined our mouse model of systemic hypoxia with a model of MI and showed that chronic hypoxia protects the heart from infarct injury and promotes angiogenesis. A proteomics analysis demonstrated that protein disulfide isomerase (PDI) is upregulated in the myocardial capillary endothelial cells of mice exposed to chronic hypoxia. Furthermore, PDI knockdown in endothelial cells in vitro increases apoptosis and inhibits migration and adhesion, indicating that PDI may play an integral role in angiogenesis. Endoglin is a co-receptor for transforming growth factor-β. In our mouse model of MI, we showed increases in endoglin expression in endothelial cells in the heart one week after surgery. Similarly, endoglin expression is increased in endothelial cells in vitro after exposure to hypoxia. Furthermore, we showed that hypoxia promotes activation of the endoglin/ALK-1/SMAD1/5 but not the endoglin/ALK-5/SMAD3 signaling pathway in endothelial cells. The induction of this pathway represents another potential mechanism for regulation of angiogenic responses in endothelial cells after MI. The results presented advance our understanding of the complex pathways involved in hypoxiamediated angiogenesis in the heart. Our findings could play a role in identifying new strategies for the treatment of ischemic heart disease.

Subjects/Keywords: hypoxia; angiogenesis; mice; endoglin; SUMO; PDI

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APA (6^th Edition):

Tian, F. (2009). THE ANGIOGENIC RESPONSE IN HYPOXIC HEART. Experimental studies in mice. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/19008

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tian, Fei. “THE ANGIOGENIC RESPONSE IN HYPOXIC HEART. Experimental studies in mice.” 2009. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed March 05, 2021. http://hdl.handle.net/2077/19008.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tian, Fei. “THE ANGIOGENIC RESPONSE IN HYPOXIC HEART. Experimental studies in mice.” 2009. Web. 05 Mar 2021.

Vancouver:

Tian F. THE ANGIOGENIC RESPONSE IN HYPOXIC HEART. Experimental studies in mice. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2009. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/2077/19008.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tian F. THE ANGIOGENIC RESPONSE IN HYPOXIC HEART. Experimental studies in mice. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2009. Available from: http://hdl.handle.net/2077/19008

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Tech

24. Samimi, Alireza. Study of Narrow-Band Spectral Characteristics of Stimulated Electromagnetic Emission (SEE) During Second Electron Gyro-Harmonic Heating.

Degree: PhD, Electrical Engineering, 2013, Virginia Tech

URL: http://hdl.handle.net/10919/51833

► Stimulated Electromagnetic Emissions SEEs may provide important diagnostic information about space plasma composition, energetics, and dynamics during active experiments in which ground-based high powered radio… (more)

▼ Stimulated Electromagnetic Emissions SEEs may provide important diagnostic information about space plasma composition, energetics, and dynamics during active experiments in which ground-based high powered radio waves are transmitted into the ionosphere. The nonlinear plasma processes producing this secondary radiation are not well understood particularly for some recent observations where the transmitter (pump) frequency is near the second harmonic of the electron gyro-frequency. New, more comprehensive, experimental observations of spectral features within 1kHz of the pump wave frequency are reported here in order to begin more careful comparisons of the experimental observations and a possible theoretical underpinning which is also provided. The experimental observations typically show two distinct types of secondary radiation spectra which are a) discrete narrowband harmonic spectral structures ordered by the ion gyro-frequency, so-called stimulated ion Bernstein Scatter (SIBS) and, b) broadband spectral structure with center frequency near 500 Hz and similar spectral bandwidth named ion acoustic parametric decay (IAPD). A theoretical model is provided that interprets these spectral features as resulting from parametric decay instabilities in which the pump field ultimately decays into high frequency upper hybrid/electron Bernstein and low frequency neutralized ion Bernstein and/or obliquely propagating ion acoustic waves at the upper hybrid interaction altitude. Detailed calculations of the threshold level, growth rate, unstable wavenumber and frequency bandwidth of the instabilities are provided for comparisons with experimental observations. An assessment of the effect of the critical instability parameters are provided including pump electric field strength, proximity of the pump frequency to the electron gyro-frequency and pump electric field geometry. The model shows quite reasonable agreement with the experimental observations. Next, a two dimensional Particle-In-Cell Monte-Carlo Collision computational model (PIC-MCC) is employed in order to consider nonlinear aspects such as 1) electron acceleration through wave-particle heating, 2) more complex nonlinear wave-wave processes and 3) temporal evolution of electron irregularities through nonlinear saturation. The simulation results show that the IB associated parametric decay is primarily associated with electron acceleration perpendicular to the geomagnetic field. More gyro-harmonic lines are typically associated with more intense heating. Heating is reduced when the pump frequency is sufficiently close to 2fce. The IA associated parametric decay instability is primarily associated with electron tail heating along the magnetic field and heating is reduced when the pump frequency is sufficiently close to 2fce. Characteristics of caviton collapse behavior become prevalent in this case. Results are discussed within the context of some recent experimental observations. Further discussions are provided of connections with past observed SEE spectral features… Advisors/Committee Members: Scales, Wayne A. (committeechair), Ruohoniemi, John Michael (committee member), Sharpe, Eric R. (committee member), Bailey, Scott M. (committee member), Pratt, Timothy J. (committee member).

Subjects/Keywords: Stimulated Electromagnetic Emission (SEE); Parametric decay instability (PDI); Oscillating two stream instability (OTSI)

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APA (6^th Edition):

Samimi, A. (2013). Study of Narrow-Band Spectral Characteristics of Stimulated Electromagnetic Emission (SEE) During Second Electron Gyro-Harmonic Heating. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/51833

Chicago Manual of Style (16^th Edition):

Samimi, Alireza. “Study of Narrow-Band Spectral Characteristics of Stimulated Electromagnetic Emission (SEE) During Second Electron Gyro-Harmonic Heating.” 2013. Doctoral Dissertation, Virginia Tech. Accessed March 05, 2021. http://hdl.handle.net/10919/51833.

MLA Handbook (7^th Edition):

Samimi, Alireza. “Study of Narrow-Band Spectral Characteristics of Stimulated Electromagnetic Emission (SEE) During Second Electron Gyro-Harmonic Heating.” 2013. Web. 05 Mar 2021.

Vancouver:

Samimi A. Study of Narrow-Band Spectral Characteristics of Stimulated Electromagnetic Emission (SEE) During Second Electron Gyro-Harmonic Heating. [Internet] [Doctoral dissertation]. Virginia Tech; 2013. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10919/51833.

Council of Science Editors:

Samimi A. Study of Narrow-Band Spectral Characteristics of Stimulated Electromagnetic Emission (SEE) During Second Electron Gyro-Harmonic Heating. [Doctoral Dissertation]. Virginia Tech; 2013. Available from: http://hdl.handle.net/10919/51833

University of Oulu

25. Moilanen, A. (Antti). Novel regulatory mechanisms and structural aspects of oxidative protein folding.

Degree: 2021, University of Oulu

URL: http://urn.fi/urn:isbn:9789526228471

►

Abstract Efficient maturation of disulfide-containing proteins in the endoplasmic reticulum (ER) requires facilitated folding, aided by various folding catalysts and chaperones. As protein folding is… (more)

▼

Abstract Efficient maturation of disulfide-containing proteins in the endoplasmic reticulum (ER) requires facilitated folding, aided by various folding catalysts and chaperones. As protein folding is a complex process, proteins may, even in the presence of endogenous folding factors, form misfolded states. Therefore, the cell has acquired several layers of quality control mechanisms to keep the folding load in the ER in balance with the folding capacity. The activity of folding catalysts is regulated to avoid stress connected to hyperoxidation. Other quality control mechanisms include the unfolded protein response (UPR) and ER-associated protein degradation (ERAD). The UPR consists of signaling cascades that sense unfolded protein stress and upregulate folding factors and other components to relieve the stress. ERAD directly removes non-native proteins. The main folding catalysts that introduce disulfide bonds to folding proteins in the ER are members of the ER oxidoreductin 1 (Ero1) family and protein disulfide isomerases (PDI). Ero1 is a sulfhydryl oxidase that reduces molecular oxygen to hydrogen peroxide to form disulfides. The newly generated disulfides are then transferred during the catalytic cycle to PDI which catalyzes disulfide formation in folding proteins. The Ero1-PDI pathway has been studied extensively by cell-based techniques, and its activity is regulated in a redox dependent manner by rearranging regulatory disulfides. However, the kinetic aspects of these regulatory functions have remained poorly characterized. In this study, we report comprehensive kinetic measurements for the Ero1-PDI pathway that reveal novel regulatory mechanisms for oxidative protein folding (OPF). These include a mechanism consisting of high affinity and apparent cooperativity for substrate oxygen to allow Ero1 to function efficiently at hypoxic conditions. We also show that different human Ero1 isoforms have differential dependence for substrate PDI with one of the isoforms, Ero1α, showing strong dependence for PDI for both redox activation as well as the catalytic cycle. This observation allowed us to describe a potential crosstalk between OPF and ERAD, in which OPF by the Ero1α-PDI pathway is downregulated, to potentially increase the efficiency of ERAD which requires reduced protein substrates. This work is concluded by a structural study of a novel chaperone, pERp1, that is crucial for our immunity, as it is involved in the folding of some immunoglobulins.

Tiivistelmä Disulfidisidoksia sisältävien proteiinien laskostumista endoplasmakalvostossa avustavat erilaiset laskostumiskatalyytit ja kaperonit. Koska laskostuminen on monimutkaista, voivat proteiinit laskostumistekijöistä huolimatta laskostua väärin. Endoplasmakalvostoon onkin kehittynyt useita laadunvarmistusmekanismeja, jotka pitävät laskostumistaakan ja -kapasiteetin tasapainossa. Laskostumiskatalyyttien aktiivisuutta voidaan säädellä, minkä avulla vältetään ylihapettumiseen liittyvä stressi. Muihin laadunvarmistuskeinoihin kuuluvat UPR (unfolded protein…

Advisors/Committee Members: Ruddock, L. (Lloyd).

Subjects/Keywords: disulfide bond; endoplasmic reticulum; oxidative protein folding; disulfidisidos; endoplasmakalvosto; proteiinien laskostuminen; ERAD; Ero1; PDI; UPR

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Moilanen, A. (. (2021). Novel regulatory mechanisms and structural aspects of oxidative protein folding. (Doctoral Dissertation). University of Oulu. Retrieved from http://urn.fi/urn:isbn:9789526228471

Chicago Manual of Style (16^th Edition):

Moilanen, A (Antti). “Novel regulatory mechanisms and structural aspects of oxidative protein folding.” 2021. Doctoral Dissertation, University of Oulu. Accessed March 05, 2021. http://urn.fi/urn:isbn:9789526228471.

MLA Handbook (7^th Edition):

Moilanen, A (Antti). “Novel regulatory mechanisms and structural aspects of oxidative protein folding.” 2021. Web. 05 Mar 2021.

Vancouver:

Moilanen A(. Novel regulatory mechanisms and structural aspects of oxidative protein folding. [Internet] [Doctoral dissertation]. University of Oulu; 2021. [cited 2021 Mar 05]. Available from: http://urn.fi/urn:isbn:9789526228471.

Council of Science Editors:

Moilanen A(. Novel regulatory mechanisms and structural aspects of oxidative protein folding. [Doctoral Dissertation]. University of Oulu; 2021. Available from: http://urn.fi/urn:isbn:9789526228471

NSYSU

26. Lee, Ju-Chien. Ulva fasciata protein disulfide isomerase and thioredoxin expression in response to hypersaline stress.

Degree: PhD, Biological Sciences, 2007, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0906107-172450

► This research has investigated the gene expression of protein disulfide isomerase (PDI; EC 5.3.4.1) and thioredoxin (Trx) in the marine macroalga Ulva fasciata Delile in… (more)

Subjects/Keywords: Salinity stress; Oxidative stress; PDI; Polyamine; Ulva fasciata

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APA (6^th Edition):

Lee, J. (2007). Ulva fasciata protein disulfide isomerase and thioredoxin expression in response to hypersaline stress. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0906107-172450

Chicago Manual of Style (16^th Edition):

Lee, Ju-Chien. “Ulva fasciata protein disulfide isomerase and thioredoxin expression in response to hypersaline stress.” 2007. Doctoral Dissertation, NSYSU. Accessed March 05, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0906107-172450.

MLA Handbook (7^th Edition):

Lee, Ju-Chien. “Ulva fasciata protein disulfide isomerase and thioredoxin expression in response to hypersaline stress.” 2007. Web. 05 Mar 2021.

Vancouver:

Lee J. Ulva fasciata protein disulfide isomerase and thioredoxin expression in response to hypersaline stress. [Internet] [Doctoral dissertation]. NSYSU; 2007. [cited 2021 Mar 05]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0906107-172450.

Council of Science Editors:

Lee J. Ulva fasciata protein disulfide isomerase and thioredoxin expression in response to hypersaline stress. [Doctoral Dissertation]. NSYSU; 2007. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0906107-172450

27. Chen, Xueping. Posttranslational oxidative modification of SOD1 in neurodegeneration.

Degree: Human Anatomy and Cell Science, 2012, University of Manitoba

URL: http://hdl.handle.net/1993/8359

► Converging evidence indicates that SOD1 aggregation is a common feature of mutant SOD1 (mSOD1)-linked FALS, and seems to be directly related to the gain-of-function toxic… (more)

▼ Converging evidence indicates that SOD1 aggregation is a common feature of mutant SOD1 (mSOD1)-linked FALS, and seems to be directly related to the gain-of-function toxic property. However, the mechanisms of protein aggregation are not fully understood. To study the contribution of modification on cysteine residues in SOD1 aggregation, we systematically examined the redox state of SOD1 cysteine residues in the G37R transgenic mouse at different stages of ALS and under oxidative stress induced by H2O2. Our data showed that under normal circumstances, cysteine 111 in SOD1 is free. Under oxidative stress, it is prone to oxidative modification by providing the thiolate anion (S-). With the progression of ALS, increased levels of oxidative insults facilitated the oxidation of thiol groups of cysteine residues. Human mutant SOD1 could generate an upper shifted band in SDS-PAGE, which turned out to be a Cys111-peroxidized SOD1 species. We also found that at different stages of ALS, accumulated oxidative stress facilitated the aggregates formation, which were not mediated by disulfide bond. The oxidative modification of cysteine 111 may promote the formation of disulfide bond-independent SOD1 aggregates. In addition, we investigated the correlation between nitrosative stress and S-nitrosylation of protein disulfide isomerase (PDI) in the mechanism of aggregates formation. Our data showed that up-regulated inducible nitric oxide synthase (iNOS) generated high levels of nitric oxide (NO), which induced S-nitrosylation of PDI with the progression of ALS in the spinal cords of mSOD1 transgenic mice. This correlation was confirmed by treating SH-SY5Y cells with NO donor SNOC to trigger the formation of S-nitrosylated PDI (SNO-PDI). When mSOD1 was overexpressed in SH-SY5Y cells, iNOS expression was up-regulated, NO generation was increased consequently. Furthermore, both SNO-PDI and mSOD1 aggregates were detected in these cells. Blocking NO generation with NOS inhibitor N-nitro-L-arginine (NNA) attenuated the S-nitrosylation of PDI; the formation of mSOD1 aggregates was inhibited as well. We conclude that NO-mediated S-nitrosylation of PDI is highly linked to the accumulation of mSOD1 aggregates in ALS. Advisors/Committee Members: Jiming, Kong (Human Anatomy and Cell Science) (supervisor), Maria, Vrontakis (Human Anatomy and Cell Science) Keding, Cheng (Human Anatomy and Cell Science) Fiona, Parkinson (Pharmacology and Therapeutics) Heather, Durhan (McGill University) (examiningcommittee).

Subjects/Keywords: Oxidative stress; Posttranslational modification; SOD1; PDI

…1.3 Protein disulfide isomerase (PDI)… …40 1.3.1 Structure of PDI… …41 1.3.2 Function of PDI… …42 1.3.3 Subcellular distribution of PDI… …43 vii 1.3.4 PDI in the neurodegenerative diseases…

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APA (6^th Edition):

Chen, X. (2012). Posttranslational oxidative modification of SOD1 in neurodegeneration. (Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/8359

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chen, Xueping. “Posttranslational oxidative modification of SOD1 in neurodegeneration.” 2012. Thesis, University of Manitoba. Accessed March 05, 2021. http://hdl.handle.net/1993/8359.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chen, Xueping. “Posttranslational oxidative modification of SOD1 in neurodegeneration.” 2012. Web. 05 Mar 2021.

Vancouver:

Chen X. Posttranslational oxidative modification of SOD1 in neurodegeneration. [Internet] [Thesis]. University of Manitoba; 2012. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1993/8359.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chen X. Posttranslational oxidative modification of SOD1 in neurodegeneration. [Thesis]. University of Manitoba; 2012. Available from: http://hdl.handle.net/1993/8359

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

28. Ndemueda, Anastásia Naufiku Nogueira. Inativação fotodinâmica da bactéria fitopatogénica Xanthomonas citri subsp. citri .

Degree: 2019, Universidade de Aveiro

URL: http://hdl.handle.net/10773/28346

► Xanthomonas citri subsp. citri é uma bactéria fitopatogénica que afeta os citrinos, causando o cancro cítrico. Esta doença tem distribuição global e representa perdas económicas… (more)

▼ Xanthomonas citri subsp. citri é uma bactéria fitopatogénica que afeta os citrinos, causando o cancro cítrico. Esta doença tem distribuição global e representa perdas económicas significativas. Face à baixa eficácia e elevada toxicidade ambiental dos tratamentos com cobre atualmente praticados, existe a necessidade de desenvolver novas abordagens ao controle do patogénico que sejam simultaneamente eficazes, economicamente viáveis e ambientalmente sustentáveis. O presente trabalho teve como objetivo avaliar a aplicabilidade da inativação fotodinâmica (PDI) de X. citri subsp. citri com um fotossensibilizador comercial, como estratégia de controle da bactéria e prevenção do cancro cítrico. Foi avaliada a PDI de X. citri subsp. citri em suspensões de células e em biofilmes construídos em suportes artificiais (ensaios in vitro) ou em folhas de laranjeira (ensaios ex-vivo). Foram testadas diferentes concentrações (1-100 μM) do fotossensibilizador azul de toluidina O (TBO) e do coadjuvante KI (1-100 mM) com irradiação durante 60 minutos com luz branca (400-700 nm, 150 mW.cm-2) artificial. Nos ensaios ex-vivo, foi também testada a irradiação com luz solar natural. Os resultados mostraram uma redução de 5,9 log na concentração de células viáveis nas suspensões expostas 80 μM de PS e uma redução de apenas 1,7 log na concentração de células viáveis nos biofilmes, com 100 μM de TBO. No entanto, na presença de KI (10-100 mM), foi possível erradicar completamente os biofilmes (redução > 6 log) com 5 μM de TBO (in vitro) ou 10 μM de TBO (ex vivo). Com luz solar natural, conseguiu-se inativação completa de biofilmes em folhas de laranjeira tratadas com 50 μM de TBO e 100 mM de KI. Os resultados mostram que embora os biofilmes de X. citri subsp. citri sejam menos suscetíveis à PDI do que as células planctónicas, a presença de KI aumenta a eficiência de inativação sendo possível atingir inativação completa após 4 horas de irradiação das folhas com luz solar natural. A PDI apresenta assim potencial de aplicação no controle do cancro cítrico em condições de campo, embora seja necessário aprofundar os estudos que permitam demonstrar que não há riscos para a fisiologia da planta ou para a qualidade dos frutos. Advisors/Committee Members: Cunha, Maria Ângela Sousa Dias Alves (advisor).

Subjects/Keywords: Inativação fotodinâmica (PDI); Xanthomonas citri subsp. citri; cancro cítrico; azul de toluidina O; iodeto de potássio

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ndemueda, A. N. N. (2019). Inativação fotodinâmica da bactéria fitopatogénica Xanthomonas citri subsp. citri . (Thesis). Universidade de Aveiro. Retrieved from http://hdl.handle.net/10773/28346

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ndemueda, Anastásia Naufiku Nogueira. “Inativação fotodinâmica da bactéria fitopatogénica Xanthomonas citri subsp. citri .” 2019. Thesis, Universidade de Aveiro. Accessed March 05, 2021. http://hdl.handle.net/10773/28346.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ndemueda, Anastásia Naufiku Nogueira. “Inativação fotodinâmica da bactéria fitopatogénica Xanthomonas citri subsp. citri .” 2019. Web. 05 Mar 2021.

Vancouver:

Ndemueda ANN. Inativação fotodinâmica da bactéria fitopatogénica Xanthomonas citri subsp. citri . [Internet] [Thesis]. Universidade de Aveiro; 2019. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10773/28346.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ndemueda ANN. Inativação fotodinâmica da bactéria fitopatogénica Xanthomonas citri subsp. citri . [Thesis]. Universidade de Aveiro; 2019. Available from: http://hdl.handle.net/10773/28346

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Akron

29. Altamimi, Rashid M. Synthesis and Photophysical Properties of Porphyrin-Containing Supramolecular Systems.

Degree: PhD, Chemistry, 2010, University of Akron

URL: http://rave.ohiolink.edu/etdc/view?acc_num=akron1291171941

► The self-assembly of organic molecules has attracted much interest because of the special properties and possible technological applications of the mesoscopic materials which are intermediate… (more)

▼ The self-assembly of organic molecules has attracted much interest because of the special properties and possible technological applications of the mesoscopic materials which are intermediate materials between molecules and solids.1 Structural and spectroscopic studies on J- and H-aggregates present valuable information for understanding interactions at the molecular level in aggregation processes, and may also provide understanding that leads to alternative molecular devices. The synthesis and preliminary photophysical properties of two generations (G1-G2) of glutamic acid-based peptide dendrimers containing free-base or zinc porphyrin at the cores were performed. In this work, steady-state absorption and fluorescence experiments for the free-base dendrimers 59 and 63 were observed to have similar spectra relative H2TPP in DMAc, while the absorption and fluorescence spectra of zinc porphyrin dendrimers 60 and 64 were almost identical to that of ZnTPP in DMAc. These dendrimers tend to not to aggregate in polar solvents like DMAc, therefore, other nonpolar solvents will be sought for self-assembly these dendrimers. Second, two electon donor (D)- acceptor (A) dyads are composed of free-base porphyrin (Fb) and perylene bisimide (PDI) groups that are linked by leucine (65) or polyleucine (n=2, the dyad 66) were prepared in this work. Fb and PDI were chosen because of the useful photophysical properties each exhibits that will enable us to perform both energy and electron transfer within each dyad. The absorption spectra of the dyads indicate a close match with the sum of the component spectra, indicating little or no electronic coupling occurs between porphyrin and PDI groups in the ground state. Due to the overlap of the emission bands of porphyrin and perylene, fluorescence quantum yield analysis could not be determined with any accuracy. Fluorescence excitation spectra will therefore be performed in the near future. Intramolecular FRET experiments will also be achieved on these two dyads, whereas these measurements will allow us to precisely determine the donor-acceptor distance at any given time. After we measure the distance between the donor-acceptor dyad, we will investigate how the rate of the electron transfer varies with the distance, and what effect the dyad structure has in controlling this rate constants.The photophysical and electrochemical properties of covalently-linked arrays of N-confused porphyrins (NCPs) are of interest to a variety of supramolecular and biomimicking materials. While differing from the parent porphyrins by inversion of only two atoms, NCPs exhibit physical and chemical properties different than normal porphyrins. The synthesis and preliminary photophysical properties of three dimeric and trimeric N-confused porphyrin (NCP) arrays (75, 77 and 80) are presented. The absorption and emission maxima for the NCP dimer (75) and trimers (77 and 80) in DMAc were found to be broader and red-shifted relative to that of NC-TPP. The fluorescence quantum yield ΦFl calculated for these NCP arrays… Advisors/Committee Members: Modarelli, David (Advisor), Calvo, Kim (Committee Chair).

Subjects/Keywords: Chemistry; porphyrin; PDI; NCPs; dyads; fluorescence; H2TPP; NC-TPP

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Altamimi, R. M. (2010). Synthesis and Photophysical Properties of Porphyrin-Containing Supramolecular Systems. (Doctoral Dissertation). University of Akron. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=akron1291171941

Chicago Manual of Style (16^th Edition):

Altamimi, Rashid M. “Synthesis and Photophysical Properties of Porphyrin-Containing Supramolecular Systems.” 2010. Doctoral Dissertation, University of Akron. Accessed March 05, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1291171941.

MLA Handbook (7^th Edition):

Altamimi, Rashid M. “Synthesis and Photophysical Properties of Porphyrin-Containing Supramolecular Systems.” 2010. Web. 05 Mar 2021.

Vancouver:

Altamimi RM. Synthesis and Photophysical Properties of Porphyrin-Containing Supramolecular Systems. [Internet] [Doctoral dissertation]. University of Akron; 2010. [cited 2021 Mar 05]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=akron1291171941.

Council of Science Editors:

Altamimi RM. Synthesis and Photophysical Properties of Porphyrin-Containing Supramolecular Systems. [Doctoral Dissertation]. University of Akron; 2010. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=akron1291171941

University of Akron

30. Smith, Timothy J. Synthesis and Photophysical Characterization of Covalent and Self-Assembled Oligo (Phenylenevinylenes) and Related Multichromophore-Containing Assemblies.

Degree: PhD, Chemistry, 2009, University of Akron

URL: http://rave.ohiolink.edu/etdc/view?acc_num=akron1249143659

► The growing need for cheap, reliable, economical, and environmentally safe sources of energy has prompted extensive research into the field of organic photovoltaics. Oligo(p-phenylenevinylenes)… (more)

▼ The growing need for cheap, reliable, economical, and environmentally safe sources of energy has prompted extensive research into the field of organic photovoltaics. Oligo(p-phenylenevinylenes) (OPVs) are model compounds for the polymer poly (p-phenylenevinylenes). These compounds are a highly conjugated, hole conductive materials used in both organic photovoltaics and organic light emitting diodes. Unfortunately, little research exists concerning the effects of nano- and microstructure on organic photovoltaic performance. In other words, how does the spatial relationship between adjacent OPV chains influence photoconductivity? The first project of this dissertation was comprised of two parts. The first part dealt with the need to improve the asymmetric synthesis of OPV chains. By modifying the current literature approach towards asymmetric OPVs, the total overall yield of these chromophores has been optimized to values that are 15 – 30% higher than current literature values. The methodology and synthetic steps are explored. This project became the basis for the second part, which was the synthesis of two OPV units attached cofacially to bridging groups, in order to study energy and electronic transfer between the two units as a function of interchain distance, angle, and/or orbital overlap. The second project of this dissertation dealt with the creation of liquid crystalline perylene diimide (PDI) aggregates through non-covalent interactions. Perylene diimides have been utilized as optimal n-type materials for photoconductive organic devices, and have strong intermolecular π-π interactions that induce specific packing orientations. The nature of the packing can be influenced by the substituent at the cyclic imide portion of the chromophore. This unit has no real effect on the ground state electronic properties of the individual chromophore because it is located at a node in the PDI interacting molecular orbitals. The PDI therefore behaves as an isolated chromophore with minimal to no ground state mixing with the imide substituent. Nevertheless, the structure of that substituent can greatly influence the bulk properties of the chromophore by directly affecting the transverse and longitudinal packing in the solid state. The utilization of a hydrazide linkage could direct the self-assembly of appropriately substituted PDIs through both hydrogen bonding and π-π stacking, into ordered arrays. The synthesis and photophysical properties of these hydrazide-linked PDIs are presented. The third and final project in this dissertation involves the self-assembly of a multichromophoric perylene diimide. Various self-assembly techniques were used to construct this assembly, including hydrogen bonding, π-π stacking, and ligation of metal-complexes, all of which provide site-specific platforms for the organized assembly of a multi-chromophoric system. The synthesis of this compound is presented. Advisors/Committee Members: Modarelli, David (Advisor).

Subjects/Keywords: Organic Chemistry; OPVs; equiv; Fluorescence; PDI; Absorption; NMR

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Smith, T. J. (2009). Synthesis and Photophysical Characterization of Covalent and Self-Assembled Oligo (Phenylenevinylenes) and Related Multichromophore-Containing Assemblies. (Doctoral Dissertation). University of Akron. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=akron1249143659

Chicago Manual of Style (16^th Edition):

Smith, Timothy J. “Synthesis and Photophysical Characterization of Covalent and Self-Assembled Oligo (Phenylenevinylenes) and Related Multichromophore-Containing Assemblies.” 2009. Doctoral Dissertation, University of Akron. Accessed March 05, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1249143659.

MLA Handbook (7^th Edition):

Smith, Timothy J. “Synthesis and Photophysical Characterization of Covalent and Self-Assembled Oligo (Phenylenevinylenes) and Related Multichromophore-Containing Assemblies.” 2009. Web. 05 Mar 2021.

Vancouver:

Smith TJ. Synthesis and Photophysical Characterization of Covalent and Self-Assembled Oligo (Phenylenevinylenes) and Related Multichromophore-Containing Assemblies. [Internet] [Doctoral dissertation]. University of Akron; 2009. [cited 2021 Mar 05]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=akron1249143659.

Council of Science Editors:

Smith TJ. Synthesis and Photophysical Characterization of Covalent and Self-Assembled Oligo (Phenylenevinylenes) and Related Multichromophore-Containing Assemblies. [Doctoral Dissertation]. University of Akron; 2009. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=akron1249143659

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