You searched for subject:(Optical coherence tomography).
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Ryerson University
1.
Mauro, Antonio.
High speed rotary system for catheter based 3-D imaging with optical coherence tomography (OCT).
Degree: 2009, Ryerson University
URL: https://digital.library.ryerson.ca/islandora/object/RULA%3A6304 
► Optical Coherence Tomography (OCT) is an addition to the other tomographic imaging techniques of x-ray computed tomography, magnetic resonance imaging, and ultrasound imaging. OCT uses…
(more)
▼ Optical Coherence Tomography (OCT) is an addition to the other tomographic imaging techniques of x-ray computed tomography, magnetic resonance imaging, and ultrasound imaging. OCT uses optical reflections of biological tissues as opposed to x-rays, RF fields, and sound waves to obtain images. A rotary and pullback system has been developed for use with OCT. The system was developed to facilitate the three dimensional imaging of various lumens in humans and animals. The system is capable of rotating at a rate of 200 Hz. At this rate the rotary system will allow for a frame acquisition rate of 200 fps which is significantly higher than the highest published acquisition rate to date of 108 fps. The probes used with the system were modeled after the Intravascular Ultrasound (IVUS) miniature torque cable design. The probes can be sealed and sterilized between subjects without being damaged; unlike the single use IVUS probes. The rotary system was used to image the outer ear of a mouse in vivo. A lateral slice from the resulting three dimensional image was compared to the general histology of a mouse ear. The image compared well to the general anatomy as found on the histology.
Subjects/Keywords: Optical coherence tomography
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APA (6th Edition):
Mauro, A. (2009). High speed rotary system for catheter based 3-D imaging with optical coherence tomography (OCT). (Thesis). Ryerson University. Retrieved from https://digital.library.ryerson.ca/islandora/object/RULA%3A6304
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mauro, Antonio. “High speed rotary system for catheter based 3-D imaging with optical coherence tomography (OCT).” 2009. Thesis, Ryerson University. Accessed January 23, 2021.
https://digital.library.ryerson.ca/islandora/object/RULA%3A6304.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mauro, Antonio. “High speed rotary system for catheter based 3-D imaging with optical coherence tomography (OCT).” 2009. Web. 23 Jan 2021.
Vancouver:
Mauro A. High speed rotary system for catheter based 3-D imaging with optical coherence tomography (OCT). [Internet] [Thesis]. Ryerson University; 2009. [cited 2021 Jan 23].
Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A6304.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mauro A. High speed rotary system for catheter based 3-D imaging with optical coherence tomography (OCT). [Thesis]. Ryerson University; 2009. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A6304
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
2.
Crowley, Shannon.
Optical coherence tomography of cortical tissue in
pilocarpine treated rats as a model for temporal lobe
epilepsy.
Degree: Biomedical Engineering, 2018, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:792792/
► Epilepsy affects over 3 million people in the United States alone. In many of those cases, the disease is refractory to medication, leaving patients limited…
(more)
▼ Epilepsy affects over 3 million people in the United
States alone. In many of those cases, the disease is refractory to
medication, leaving patients limited in their daily lives. When
oral medication does not mitigate or relieve seizure activity,
neurosurgery is performed in order to remove the seizure centers of
the brain. Herein lies the unmet need in the treatment of this
disease. This research is the first step toward creating a novel
intraoperative microscope that can delineate the boundary between
healthy and epileptogenic tissue in order to assist surgeons in the
surgical resection of the diseased tissue in real time. This
research aims to use
Optical Coherence Tomography (OCT) to quantify
the changes before and after seizure activity in cortical tissue.
In a rodent model, seizures were induced using pilocarpine and
verified by electrocorticography (ECoG). OCT was utilized to
quantify the scattering coefficient, blood flow, and the structure
of cortical tissue. The
optical scattering coefficient of the
cortical tissue exhibited a significant increase after the induced
seizure activity. This distinct change in the
optical property of
tissue, which can be detected by OCT in real time and without
fluorescence, supports the technical feasibility of the proposed
intraoperative microscope.
Advisors/Committee Members: Lee, Jonghwan (Advisor), Asaad, Wael (Reader), Borton, David (Reader).
Subjects/Keywords: Optical coherence tomography
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APA (6th Edition):
Crowley, S. (2018). Optical coherence tomography of cortical tissue in
pilocarpine treated rats as a model for temporal lobe
epilepsy. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:792792/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Crowley, Shannon. “Optical coherence tomography of cortical tissue in
pilocarpine treated rats as a model for temporal lobe
epilepsy.” 2018. Thesis, Brown University. Accessed January 23, 2021.
https://repository.library.brown.edu/studio/item/bdr:792792/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Crowley, Shannon. “Optical coherence tomography of cortical tissue in
pilocarpine treated rats as a model for temporal lobe
epilepsy.” 2018. Web. 23 Jan 2021.
Vancouver:
Crowley S. Optical coherence tomography of cortical tissue in
pilocarpine treated rats as a model for temporal lobe
epilepsy. [Internet] [Thesis]. Brown University; 2018. [cited 2021 Jan 23].
Available from: https://repository.library.brown.edu/studio/item/bdr:792792/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Crowley S. Optical coherence tomography of cortical tissue in
pilocarpine treated rats as a model for temporal lobe
epilepsy. [Thesis]. Brown University; 2018. Available from: https://repository.library.brown.edu/studio/item/bdr:792792/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Limerick
3.
Kredzinski, Lukasz.
1550 nm superluminescent diode and anti-stokes effect CCD camera based optical coherence tomography for full-field optical metrology.
Degree: 2015, University of Limerick
URL: http://hdl.handle.net/10344/4834
► peer-reviewed
Optical Coherence Tomography (OCT) is a well-established non-invasive imaging technology capable of carrying out 3D high-resolution cross-sectional images of the internal microstructure of examined…
(more)
▼ peer-reviewed
Optical Coherence Tomography (OCT) is a well-established non-invasive
imaging technology capable of carrying out 3D high-resolution cross-sectional images
of the internal microstructure of examined material. However, almost all of these
systems are expensive, requiring the use of complex optical setups, expensive light
sources and complicated scanning of the sample under test. In addition, most of these
systems have not taken advantage of the competitively priced optical components
available at wavelength within the main optical communications band located in the
1550 nm region. A comparatively simple and inexpensive full-field OCT system (FFOCT),
based on a Superluminescent Diode (SLD) with an Erbium-Doped Fiber
Amplifier (EDFA) light source and anti-stokes imaging device was constructed, to
perform 3D cross-sectional imaging. This kind of inexpensive setup with moderate
resolution could be applicable in low-level biomedical and industrial diagnostics. This
work involves assembly, calibration of the system and determines its suitability for
imaging structures of biological tissues such as teeth, which has low absorption at 1550
nm. The first ever 1550 nm full-field OCT system is presented.
Advisors/Committee Members: Connelly, Michael J., SFI.
Subjects/Keywords: optical coherence tomography
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APA (6th Edition):
Kredzinski, L. (2015). 1550 nm superluminescent diode and anti-stokes effect CCD camera based optical coherence tomography for full-field optical metrology. (Thesis). University of Limerick. Retrieved from http://hdl.handle.net/10344/4834
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kredzinski, Lukasz. “1550 nm superluminescent diode and anti-stokes effect CCD camera based optical coherence tomography for full-field optical metrology.” 2015. Thesis, University of Limerick. Accessed January 23, 2021.
http://hdl.handle.net/10344/4834.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kredzinski, Lukasz. “1550 nm superluminescent diode and anti-stokes effect CCD camera based optical coherence tomography for full-field optical metrology.” 2015. Web. 23 Jan 2021.
Vancouver:
Kredzinski L. 1550 nm superluminescent diode and anti-stokes effect CCD camera based optical coherence tomography for full-field optical metrology. [Internet] [Thesis]. University of Limerick; 2015. [cited 2021 Jan 23].
Available from: http://hdl.handle.net/10344/4834.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kredzinski L. 1550 nm superluminescent diode and anti-stokes effect CCD camera based optical coherence tomography for full-field optical metrology. [Thesis]. University of Limerick; 2015. Available from: http://hdl.handle.net/10344/4834
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Texas – Austin
4.
Kim, Eun Song.
Sensors and structured beams in optical coherence tomography.
Degree: PhD, Electrical and Computer engineering, 2017, University of Texas – Austin
URL: http://dx.doi.org/10.26153/tsw/3145
► Optical coherence tomography (OCT) is an emerging medical imaging technique that provides images of various tissue structures at micrometer scale resolution. A swept source laser…
(more)
▼ Optical coherence tomography (OCT) is an emerging medical imaging technique that provides images of various tissue structures at micrometer scale resolution. A swept source laser which emits time-varying wavelengths light at a high-speed was developed that greatly improves OCT processing speed and image resolution. This dissertation presents system developments for swept source based OCT. I have designed and demonstrated three different OCT systems that can be used for diagnostic applications. First, I present a common-path OCT system with a cleaved
optical fiber as a probe. The system is built as a tactile sensor for implementation in surgical robots. A tactile sensor, often referred to as a force sensor, is a device that is sensitive to applied force or pressure. Since the system has a high sensitivity to pressure and a compact size, the sensor is compatible with the surgical robots field which require fine force control. This new sensor may aid in diagnosing diseased tissue or cells by measuring their Young' s modulus.
Secondly, an Angular/Longitudinal Doppler OCT system (ALD-OCT) was constructed to sense the rotation of an object. Previous work has shown, it is feasible to detect a linearly moving object by Doppler OCT. However, ALD-OCT, OCT utilizes a helical phase shape beam that, has been studied due to its distinct characteristics. An application of using a vortex beam is sensing a rotating object by measuring the angular Doppler shift from the beam reflected off the object. ALD-OCT can utilize depth resolved analysis and be implemented to detect helical shaped particles or the vorticity of blood flows under the skin or in the retina noninvasively.
Lastly, we propose several designs of
optical probes for a swept source OCT system. The designs of the GRIN lens bundle probes were presented to demonstrate angled illumination and detection techniques in OCT systems. The beam profiles of the output beams from the probes were analyzed theoretically using ABCD ray matrices. We present a method to measure the beam profile of a sweeping wavelength laser source, which can be applied to measure any
optical probes connected to the swept source laser.
Advisors/Committee Members: Milner, Thomas E. (advisor), Valvano, Jonathan W (committee member), Dunn, Andrew (committee member), Tunnell, James (committee member), Daigle, Hugh (committee member).
Subjects/Keywords: Optical coherence tomography
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APA ·
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APA (6th Edition):
Kim, E. S. (2017). Sensors and structured beams in optical coherence tomography. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://dx.doi.org/10.26153/tsw/3145
Chicago Manual of Style (16th Edition):
Kim, Eun Song. “Sensors and structured beams in optical coherence tomography.” 2017. Doctoral Dissertation, University of Texas – Austin. Accessed January 23, 2021.
http://dx.doi.org/10.26153/tsw/3145.
MLA Handbook (7th Edition):
Kim, Eun Song. “Sensors and structured beams in optical coherence tomography.” 2017. Web. 23 Jan 2021.
Vancouver:
Kim ES. Sensors and structured beams in optical coherence tomography. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2017. [cited 2021 Jan 23].
Available from: http://dx.doi.org/10.26153/tsw/3145.
Council of Science Editors:
Kim ES. Sensors and structured beams in optical coherence tomography. [Doctoral Dissertation]. University of Texas – Austin; 2017. Available from: http://dx.doi.org/10.26153/tsw/3145
Ryerson University
5.
Demidov, Valentin.
Imaging the Electro-Kinetic Response of Biological Tissues with Optical Coherence Tomography.
Degree: 2013, Ryerson University
URL: https://digital.library.ryerson.ca/islandora/object/RULA%3A2422
► This thesis reports on developing a novel approach to imaging the electro-kinetic response of biological tissues with optical coherence tomography (OCT). The changes of backscattered…
(more)
▼ This thesis reports on developing a novel approach to imaging the electro-kinetic response of biological tissues with
optical coherence tomography (OCT). The changes of backscattered OCT signal from tissues were investigated with a low frequency AC electric field being applied to the tissues. Advanced processing algorithms were developed to analyze the amplitude and phase changes of OCT signal. Two-dimensional electrically induced
optical changes (EIOC) amplitude and phase images related to the electro-kinetic response of soft tissues were obtained with depth resolution and compared with structural OCT images. The procedure for removing the background noise from EIOC images was introduced.
Advisors/Committee Members: Ryerson University (Degree grantor).
Subjects/Keywords: Optical coherence tomography; Tissues; Electrokinetics
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APA (6th Edition):
Demidov, V. (2013). Imaging the Electro-Kinetic Response of Biological Tissues with Optical Coherence Tomography. (Thesis). Ryerson University. Retrieved from https://digital.library.ryerson.ca/islandora/object/RULA%3A2422
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Demidov, Valentin. “Imaging the Electro-Kinetic Response of Biological Tissues with Optical Coherence Tomography.” 2013. Thesis, Ryerson University. Accessed January 23, 2021.
https://digital.library.ryerson.ca/islandora/object/RULA%3A2422.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Demidov, Valentin. “Imaging the Electro-Kinetic Response of Biological Tissues with Optical Coherence Tomography.” 2013. Web. 23 Jan 2021.
Vancouver:
Demidov V. Imaging the Electro-Kinetic Response of Biological Tissues with Optical Coherence Tomography. [Internet] [Thesis]. Ryerson University; 2013. [cited 2021 Jan 23].
Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A2422.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Demidov V. Imaging the Electro-Kinetic Response of Biological Tissues with Optical Coherence Tomography. [Thesis]. Ryerson University; 2013. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A2422
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Vanderbilt University
6.
Tucker-Schwartz, Jason Michael.
Development of Photothermal Optical Coherence Tomography
for In Vivo Imaging of Contrast Agents.
Degree: PhD, Biomedical Engineering, 2015, Vanderbilt University
URL: http://hdl.handle.net/1803/13545
► Sensitive and specific noninvasive in vivo imaging of contrast agents and endogenous molecules can supply molecular and functional information in animal models, providing essential insight…
(more)
▼ Sensitive and specific noninvasive in vivo imaging of contrast agents and endogenous molecules can supply molecular and functional information in animal models, providing essential insight into mechanisms of disease formation and progression, drug delivery, and treatment response. In cancer in particular, high resolution imaging is essential for capturing spatial heterogeneities in molecular expression and the tumor microenvironment that cause significant barriers to treatment efficacy and drug delivery.
Optical coherence tomography (OCT) fills the niche of cellular-level resolution and penetration depths in tissue that exceed those obtained with microscopy, an attractive regime for imaging mouse models of cancer. In this dissertation, photothermal OCT (PTOCT), a functional extension of OCT, was developed for in vivo imaging of a variety of contrast agents and drug delivery vectors in live animals. The PTOCT signal was thoroughly characterized in phantoms and compared to theory, followed by a demonstration of picomolar sensitivity to gold nanorod contrast agents. Gold nanorods at physiologically relevant concentrations were then identified from within a live mouse at depths exceeding the standard limits of high resolution
optical microscopy. Then, heterogeneities in gold nanorod delivery to tumors were imaged in the context of tissue and vessel morphology, demonstrating the utility of PTOCT as part of a powerful multimodality imaging platform for the development of nanomedicines and drug delivery technologies. The uptake of gold nanorods into mouse mammary tumors were tracked in three dimensions over 24 hours, and the specificity of the PTOCT signal was verified using multiphoton microscopy. Finally, photothermal
optical lock-in
optical coherence tomography (poli-OCT) was used to increase system throughput and allow for real time photothermal imaging. In vivo poli-OCT of indocyanine green identified lymphatic vessels in a mouse ear, and also identified picomolar concentrations of gold nanorods in subcutaneous injections at frame rates ten times faster than previously reported. Overall, the development of in vivo PTOCT combined with existing morphological and hemodynamic imaging capabilities of OCT will enable more comprehensive studies of drug delivery and molecular expression in mouse models of disease, particularly cancer.
Advisors/Committee Members: Craig Duvall (committee member), Duco Jansen (committee member), Sharon Weiss (committee member), Tom Yankeelov (committee member), Melissa Skala (Committee Chair).
Subjects/Keywords: imaging; optical coherence tomography
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APA ·
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APA (6th Edition):
Tucker-Schwartz, J. M. (2015). Development of Photothermal Optical Coherence Tomography
for In Vivo Imaging of Contrast Agents. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/13545
Chicago Manual of Style (16th Edition):
Tucker-Schwartz, Jason Michael. “Development of Photothermal Optical Coherence Tomography
for In Vivo Imaging of Contrast Agents.” 2015. Doctoral Dissertation, Vanderbilt University. Accessed January 23, 2021.
http://hdl.handle.net/1803/13545.
MLA Handbook (7th Edition):
Tucker-Schwartz, Jason Michael. “Development of Photothermal Optical Coherence Tomography
for In Vivo Imaging of Contrast Agents.” 2015. Web. 23 Jan 2021.
Vancouver:
Tucker-Schwartz JM. Development of Photothermal Optical Coherence Tomography
for In Vivo Imaging of Contrast Agents. [Internet] [Doctoral dissertation]. Vanderbilt University; 2015. [cited 2021 Jan 23].
Available from: http://hdl.handle.net/1803/13545.
Council of Science Editors:
Tucker-Schwartz JM. Development of Photothermal Optical Coherence Tomography
for In Vivo Imaging of Contrast Agents. [Doctoral Dissertation]. Vanderbilt University; 2015. Available from: http://hdl.handle.net/1803/13545
Vanderbilt University
7.
Poole, Kristin Marie.
Quantitative optical imaging of vascular structure and function in a model of peripheral arterial disease.
Degree: MS, Biomedical Engineering, 2012, Vanderbilt University
URL: http://hdl.handle.net/1803/13329
► Peripheral arterial disease (PAD) leads to an increased risk of myocardial infarction and stroke, increased mortality, and reduced quality of life. The mouse hind limb…
(more)
▼ Peripheral arterial disease (PAD) leads to an increased risk of myocardial infarction and stroke, increased mortality, and reduced quality of life. The mouse hind limb ischemia (HLI) model is the most commonly used system for studying the mechanisms of collateral vessel formation and for testing new PAD therapies, but there is a lack of techniques for acquiring physiologically-relevant, quantitative data intravitally in this model. In this work, non-invasive, quantitative
optical imaging techniques were applied to the mouse HLI model over a time course. Quantification of hemoglobin oxygen saturation with hyperspectral imaging was sensitive to changes in the oxygenation of the ischemic hind limb. Hemoglobin oxygen saturation measurements also correlated well with two standard measures of hind limb recovery: the perfusion ratio and probe-based tissue oxygen tension. Additionally,
optical coherence tomography (OCT) techniques were applied to study changes in blood flow with high resolution. Restoration of blood flow in vessels distal to the site of occlusion was monitored non-invasively with Doppler OCT. Three dimensional images of the adductor muscle acquired with Doppler OCT revealed changes in collateral vessel morphology consistent with post-mortem analyses in previous studies. This visualization of hind limb vasculature in a given mouse over time without contrast agents or post-mortem methods was previously unattainable. Taken together, hyperspectral imaging and OCT enable acquisition of both functional and morphological data which fill the gaps in acquiring a complete picture of recovery in the mouse HLI model. Therefore, these
optical imaging methods hold promise as tools for studying the mechanisms of vascular recovery and evaluating novel therapeutic treatments in preclinical studies.
Advisors/Committee Members: Craig L. Duvall (Committee Chair), Melissa C. Skala (Committee Chair).
Subjects/Keywords: hyperspectral imaging; optical coherence tomography
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APA (6th Edition):
Poole, K. M. (2012). Quantitative optical imaging of vascular structure and function in a model of peripheral arterial disease. (Thesis). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/13329
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Poole, Kristin Marie. “Quantitative optical imaging of vascular structure and function in a model of peripheral arterial disease.” 2012. Thesis, Vanderbilt University. Accessed January 23, 2021.
http://hdl.handle.net/1803/13329.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Poole, Kristin Marie. “Quantitative optical imaging of vascular structure and function in a model of peripheral arterial disease.” 2012. Web. 23 Jan 2021.
Vancouver:
Poole KM. Quantitative optical imaging of vascular structure and function in a model of peripheral arterial disease. [Internet] [Thesis]. Vanderbilt University; 2012. [cited 2021 Jan 23].
Available from: http://hdl.handle.net/1803/13329.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Poole KM. Quantitative optical imaging of vascular structure and function in a model of peripheral arterial disease. [Thesis]. Vanderbilt University; 2012. Available from: http://hdl.handle.net/1803/13329
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Texas A&M University
8.
Kim, Wihan.
Development of Molecular Contrast-enhanced Imaging for Optical Coherence Tomography.
Degree: PhD, Biomedical Engineering, 2017, Texas A&M University
URL: http://hdl.handle.net/1969.1/187188
► Biological imaging techniques that are able to detect a contrast-enhanced signal from the target molecules have been widely applied to various techniques in the imaging…
(more)
▼ Biological imaging techniques that are able to detect a contrast-enhanced signal from the target molecules have been widely applied to various techniques in the imaging field. The complex biological environment provides numerous and more efficient pathways along which the chromophores (light absorber) may release its energy. This energy can provide not only morphological information, but also specific molecular information such as a biochemical map of a sample. All diseases correlate with both morphological and biochemical changes.
Optical coherence tomography (OCT) system is one of the biological imaging techniques. OCT has widely been applied to many medical/clinical fields, giving benefit from a penetration depth of a few millimeters while maintaining a spatial resolution on the order of a micron. Unfortunately, OCT lacks the straightforward functional molecular imaging extensions available for other technologies, e.g. confocal fluorescence microscopy and fluorescence diffuse
optical tomography. This is largely because incoherent processes such as fluorescence emission and Raman scattering are not readily detectable with low
coherence interferometry that is the central technique that underlies all OCT systems. Despite a drawback of molecular imaging with OCT, it is highly desirable to measure not only morphological, but also molecular information from either endogenous or exogenous molecules.
In order to overcome the limitation of molecular contrast imaging for OCT, our group has been researched the hybrid OCT imaging technique and a new exogenous contrast agent. Our contrast-enhanced imaging technique integrates OCT with a well-researched and well-established technique: two-colored pump-probe absorption spectroscopy. Our novel imaging technique is called Pump-Probe OCT (PPOCT). Based upon current successful results, molecular imaging with OCT potentially gives us the ability to identify pathologies. In order to expand the capacity of PPOCT, this dissertation focuses on development of molecular contrast-enhanced imaging for
optical coherence tomography (OCT).
In the first phase of the research, we developed and optimized for sensitivity a two-color ground state recovery Pump-Probe
Optical Coherence Tomography (gsrPPOCT) system and signal algorithm to measure the contrast-enhanced signal of endogenous and exogenous contrast agents such as Hemoglobin (Hb) and Methylene blue (MB) from in vivo samples. Depending on the absorption peak of a target molecule, the pump light sources for PPOCT used 532nm Q-switched laser or 663nm diode laser. Based on different experimental application, Ti:sapp or SLD of 830nm center wavelength were utilized. The PPCOT system was firstly used to image Hb of in vivo vasulature in a Xenopus laevis as the endogenous contrast agent and a larval stage zebrafish using MB as the exogenous contrast agent via transient changes in light absorption. Their morphological in addition to molecular specific information from a live animal was described. The incorporation of a pump laser in an otherwise…
Advisors/Committee Members: Applegate, Brian E. (advisor), Jo, Javier A. (advisor), Yeh, Alvin T. (committee member), Kim, Yongjoe (committee member).
Subjects/Keywords: Molecular Contrast; Optical Coherence Tomography
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APA ·
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Manager
APA (6th Edition):
Kim, W. (2017). Development of Molecular Contrast-enhanced Imaging for Optical Coherence Tomography. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/187188
Chicago Manual of Style (16th Edition):
Kim, Wihan. “Development of Molecular Contrast-enhanced Imaging for Optical Coherence Tomography.” 2017. Doctoral Dissertation, Texas A&M University. Accessed January 23, 2021.
http://hdl.handle.net/1969.1/187188.
MLA Handbook (7th Edition):
Kim, Wihan. “Development of Molecular Contrast-enhanced Imaging for Optical Coherence Tomography.” 2017. Web. 23 Jan 2021.
Vancouver:
Kim W. Development of Molecular Contrast-enhanced Imaging for Optical Coherence Tomography. [Internet] [Doctoral dissertation]. Texas A&M University; 2017. [cited 2021 Jan 23].
Available from: http://hdl.handle.net/1969.1/187188.
Council of Science Editors:
Kim W. Development of Molecular Contrast-enhanced Imaging for Optical Coherence Tomography. [Doctoral Dissertation]. Texas A&M University; 2017. Available from: http://hdl.handle.net/1969.1/187188
University of Connecticut
9.
Mahdian, Mina.
Tissue Characterization Using Optical Coherence Tomography.
Degree: Master of Dental Science, Dental Science, 2015, University of Connecticut
URL: https://opencommons.uconn.edu/gs_theses/793
► Optical coherence tomography (OCT) is a non-invasive imaging modality, which provides real-time near-histology resolution images. In dentistry, OCT has been used for early detection…
(more)
▼ Optical coherence tomography (OCT) is a non-invasive imaging modality, which provides real-time near-histology resolution images. In dentistry, OCT has been used for early detection of carious lesions, malignant changes in the oral tissues and other indications. However, to the best of our knowledge there is no information regarding the ability of this imaging modality in differentiating between different types of tissues in the oral cavity. If OCT proves to be able to render information regarding the properties of tissues, it can be used to detect pathological changes at an early stage, which results in better treatment outcomes. In this study, we imaged five types of tissues, i.e., human enamel, human cortical bone, human trabecular bone, rat masseteric muscle and fatty tissue plus water and air using OCT (Axsun Inc. Billerica, MA). We then developed an algorithm to determine the intensity profile, pixel intensity values and histograms for each sample. The same tissues plus water and air were also imaged using cone beam computed
tomography (CBCT) and gray scale values were measured for each tissue. The mean pixel intensity values and gray scale values for the OCT images and CBCT scans of each tissue were reported, respectively. A similar pattern was observed in the pixel intensity values and gray scale values in both imaging modalities. Therefore, within the limitations of this study, it was concluded that OCT can reliably differentiate between different tissues (hard and soft tissues)
in vitro and the results are comparable to CBCT gray scale values
Advisors/Committee Members: Alan Lurie, Sumit Yadav, Aditya Tadinada.
Subjects/Keywords: Tissue Characterization; Optical Coherence Tomography
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APA (6th Edition):
Mahdian, M. (2015). Tissue Characterization Using Optical Coherence Tomography. (Masters Thesis). University of Connecticut. Retrieved from https://opencommons.uconn.edu/gs_theses/793
Chicago Manual of Style (16th Edition):
Mahdian, Mina. “Tissue Characterization Using Optical Coherence Tomography.” 2015. Masters Thesis, University of Connecticut. Accessed January 23, 2021.
https://opencommons.uconn.edu/gs_theses/793.
MLA Handbook (7th Edition):
Mahdian, Mina. “Tissue Characterization Using Optical Coherence Tomography.” 2015. Web. 23 Jan 2021.
Vancouver:
Mahdian M. Tissue Characterization Using Optical Coherence Tomography. [Internet] [Masters thesis]. University of Connecticut; 2015. [cited 2021 Jan 23].
Available from: https://opencommons.uconn.edu/gs_theses/793.
Council of Science Editors:
Mahdian M. Tissue Characterization Using Optical Coherence Tomography. [Masters Thesis]. University of Connecticut; 2015. Available from: https://opencommons.uconn.edu/gs_theses/793
University of Manitoba
10.
Thakur, Rahul.
Design and implementation of full field-optical coherence tomography on an Olympus IX73 microscope.
Degree: Electrical and Computer Engineering, 2017, University of Manitoba
URL: http://hdl.handle.net/1993/32664
► Optical Coherence Tomography (OCT) has established itself as an important imaging technology for biomedical and industrial applications. In this thesis, we describe the design and…
(more)
▼ Optical Coherence Tomography (OCT) has established itself as an important imaging technology for biomedical and industrial applications. In this thesis, we describe the design and implementation of a novel Full-Field OCT
optical module that is specifically designed to fit inside an Olympus IX73 inverted microscope. We describe the design, components, and implementation of this novel
optical module in detail. The resulting FF-OCT setup (microscope and OCT
optical module) can be used as either a Time-Domain system or a Fourier-Domain (swept-source) system, without the need for considerable changes to the OCT
optical module. However, we used our FF-OCT setup to implement a Time-Domain FF-OCT system. We describe our FF-OCT system’s data acquisition process and Graphical User Interface (GUI) in detail, and we present imaging results obtained for samples comprised of stacks of glass coverslips.
Advisors/Committee Members: Sherif, Sherif (Electrical and Computer Engineering) (supervisor), Major, Arkady (Electrical and Computer Engineering).
Subjects/Keywords: Full Field; Optical Coherence Tomography
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APA (6th Edition):
Thakur, R. (2017). Design and implementation of full field-optical coherence tomography on an Olympus IX73 microscope. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/32664
Chicago Manual of Style (16th Edition):
Thakur, Rahul. “Design and implementation of full field-optical coherence tomography on an Olympus IX73 microscope.” 2017. Masters Thesis, University of Manitoba. Accessed January 23, 2021.
http://hdl.handle.net/1993/32664.
MLA Handbook (7th Edition):
Thakur, Rahul. “Design and implementation of full field-optical coherence tomography on an Olympus IX73 microscope.” 2017. Web. 23 Jan 2021.
Vancouver:
Thakur R. Design and implementation of full field-optical coherence tomography on an Olympus IX73 microscope. [Internet] [Masters thesis]. University of Manitoba; 2017. [cited 2021 Jan 23].
Available from: http://hdl.handle.net/1993/32664.
Council of Science Editors:
Thakur R. Design and implementation of full field-optical coherence tomography on an Olympus IX73 microscope. [Masters Thesis]. University of Manitoba; 2017. Available from: http://hdl.handle.net/1993/32664
University of Texas – Austin
11.
Wang, Bingqing.
Optical designs and image processing algorithms for optical coherence tomography detection of glaucoma.
Degree: PhD, Biomedical Engineering, 2014, University of Texas – Austin
URL: http://hdl.handle.net/2152/31289
► Optical Coherence Tomography (OCT) is an optical tomography technique which provides high resolution non-invasive three-dimensional (3D) structural images of the sample based on coherent properties…
(more)
▼ Optical Coherence Tomography (OCT) is an
optical tomography technique which provides high resolution non-invasive three-dimensional (3D) structural images of the sample based on coherent properties of light. The dissertation focuses on the use of OCT systems for detecting glaucoma, which is the second leading cause of blindness worldwide. First, as a prerequisite of analyzing ophthalmologic OCT images, a retinal sublayer segmentation algorithm is presented and implemented with GPU assisted computation. Then, a polarization-sensitive
optical coherence tomography (PS-OCT) system was constructed for the study of glaucoma. Three closely related clinical and animal studies on early-stage glaucoma detection using either OCT or PS-OCT were performed. Statistical analysis of the study results indicates that the scattering property of retinal nerve fiber layer (RNFL) is the earliest indicator for glaucoma. Finally, to investigate the scattering properties of RNFL, a pathlength-multiplexed scattering-angle-diverse
optical coherence tomography (PM-SAD-OCT) system was designed and built. PM-SAD-OCT images were collected from human and rodent retina as well as earthworm nerve cord. PM-SAD-OCT system shows promising potentials to detect neurodegenerative diseases including glaucoma.
Advisors/Committee Members: Rylander, H. Grady (Henry Grady), 1948- (advisor), Milner, Thomas E. (advisor), Tunnell, James W. (committee member), Dunn, Andrew K. (committee member), Bovik, Alan C. (committee member).
Subjects/Keywords: Optical coherence tomography; Image processing
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APA (6th Edition):
Wang, B. (2014). Optical designs and image processing algorithms for optical coherence tomography detection of glaucoma. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/31289
Chicago Manual of Style (16th Edition):
Wang, Bingqing. “Optical designs and image processing algorithms for optical coherence tomography detection of glaucoma.” 2014. Doctoral Dissertation, University of Texas – Austin. Accessed January 23, 2021.
http://hdl.handle.net/2152/31289.
MLA Handbook (7th Edition):
Wang, Bingqing. “Optical designs and image processing algorithms for optical coherence tomography detection of glaucoma.” 2014. Web. 23 Jan 2021.
Vancouver:
Wang B. Optical designs and image processing algorithms for optical coherence tomography detection of glaucoma. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2014. [cited 2021 Jan 23].
Available from: http://hdl.handle.net/2152/31289.
Council of Science Editors:
Wang B. Optical designs and image processing algorithms for optical coherence tomography detection of glaucoma. [Doctoral Dissertation]. University of Texas – Austin; 2014. Available from: http://hdl.handle.net/2152/31289
University of Illinois – Urbana-Champaign
12.
Li, Di.
Catheter for endoscopic magnetomotive optical coherence tomography.
Degree: MS, 0139, 2011, University of Illinois – Urbana-Champaign
URL: http://hdl.handle.net/2142/18621
► In this thesis, a catheter design is proposed for endoscopic magnetomotive optical coherence tomography (MM-OCT). Magnetomotive optical coherence tomography is a novel technique which uses…
(more)
▼ In this thesis, a catheter design is proposed for endoscopic magnetomotive
optical coherence tomography (MM-OCT). Magnetomotive
optical coherence tomography is a novel technique which uses targeted magnetic contrast agents for contrast enhancement of OCT imaging. In MM-OCT, microspheres and magnetic nanoparticles (MNPs) are introduced into tissue and an electromagnet is used to generate a small modulated magnetic field within the tissue during OCT imaging. The magnetic field will introduce mechanical displacement of the MNPs, which can be detected, and the MM-OCT signal can be measured. The current bench-top set-up does not allow for in vivo MM-OCT imaging because the magnetic field is provide by a solenoid with an outer diameter of ~18 mm and an axial thickness of ~9 mm. A magnetomotive catheter design was developed by wrapping small coil around the distal end of a standard OCT catheter to combine the novel MM-OCT technology and catheter-based OCT. The coil has a small size while providing a local magnetic field for MM-OCT imaging. This magnetomotive catheter will enable investigations of in vivo magnetomotive contrast enhancement from the magnetic agents used in MM-OCT imaging.
Advisors/Committee Members: Boppart, Stephen A. (advisor).
Subjects/Keywords: Optical Coherence Tomography; Catheter; Magnetomotive optical coherence tomography (OCT)
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APA (6th Edition):
Li, D. (2011). Catheter for endoscopic magnetomotive optical coherence tomography. (Thesis). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/18621
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Li, Di. “Catheter for endoscopic magnetomotive optical coherence tomography.” 2011. Thesis, University of Illinois – Urbana-Champaign. Accessed January 23, 2021.
http://hdl.handle.net/2142/18621.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Li, Di. “Catheter for endoscopic magnetomotive optical coherence tomography.” 2011. Web. 23 Jan 2021.
Vancouver:
Li D. Catheter for endoscopic magnetomotive optical coherence tomography. [Internet] [Thesis]. University of Illinois – Urbana-Champaign; 2011. [cited 2021 Jan 23].
Available from: http://hdl.handle.net/2142/18621.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Li D. Catheter for endoscopic magnetomotive optical coherence tomography. [Thesis]. University of Illinois – Urbana-Champaign; 2011. Available from: http://hdl.handle.net/2142/18621
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Ryerson University
13.
Razani, Marjan.
Development of optical coherence tomography technique for clinical diagnostics and monitoring.
Degree: 2016, Ryerson University
URL: https://digital.library.ryerson.ca/islandora/object/RULA%3A5771
► This dissertation describes techniques that use Optical Coherence Tomography techniques developed for the detection of shear wave propagation in different phantoms, and the use of…
(more)
▼ This dissertation describes techniques that use
Optical Coherence Tomography techniques developed for the detection of shear wave propagation in different phantoms, and the use of such waves to enhance the transport of nanoparticles in tissue equivalent phantoms. In the first study, we explored the potential of measuring shear wave propagation using
optical co-herence elastography (OCE) in an inhomogeneous phantom and carotid artery samples based on a swept source
optical coherence tomography (OCT) system. Shear waves were generated using a piezoelectric transducer transmitting sine-wave bursts of 400 μs duration, applying acoustic radiation force (ARF) to inhomogeneous phantoms and carotid artery samples, syn-chronized with a swept-source OCT (SS-OCT) imaging system. The phantoms were com-posed of gelatin and titanium dioxide whereas the carotid artery samples were embedded in propagating shear waves in inhomogeneous tissue equivalent phantoms and carotid artery samples using the ARF of an ultrasound transducer, and measuring the shear wave speed and its associated properties in the different layers with OCT phase maps. In the second study, we present a technique to image the enhanced particle displacement generated using an acoustic radiation force (ARF) excitation source. A MEMS-VCSEL swept source
Optical Coherence Tomography (SS-OCT) system with a center wavelength of 1310 nm, a bandwidth of 100nm, and an A-scan rate of 100 kHz was used to detect gold nanoparticle displacement. ARF was applied after the nanoparticles diffused into a collagen matrix (of different collagen concen-trations and for a tissue engineered MCF-7 breast cancer cell construct). Differential OCT speckle variance images with and without the ARF were used to estimate the particle dis-placement. The images were used to detect the microscopic enhancement of nanoparticle displacement generated by the ARF. Using this OCT imaging technique, the enhanced transport of particles though a collagen gel after using an ARF excitation was imaged and analysed.
Advisors/Committee Members: Kolios, Michael C. (Degree supervisor).
Subjects/Keywords: Optical Coherence Tomography; Optical amplifiers; Diognostic imaging
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APA (6th Edition):
Razani, M. (2016). Development of optical coherence tomography technique for clinical diagnostics and monitoring. (Thesis). Ryerson University. Retrieved from https://digital.library.ryerson.ca/islandora/object/RULA%3A5771
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Razani, Marjan. “Development of optical coherence tomography technique for clinical diagnostics and monitoring.” 2016. Thesis, Ryerson University. Accessed January 23, 2021.
https://digital.library.ryerson.ca/islandora/object/RULA%3A5771.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Razani, Marjan. “Development of optical coherence tomography technique for clinical diagnostics and monitoring.” 2016. Web. 23 Jan 2021.
Vancouver:
Razani M. Development of optical coherence tomography technique for clinical diagnostics and monitoring. [Internet] [Thesis]. Ryerson University; 2016. [cited 2021 Jan 23].
Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A5771.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Razani M. Development of optical coherence tomography technique for clinical diagnostics and monitoring. [Thesis]. Ryerson University; 2016. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A5771
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Minnesota
14.
Lee, Janet Tien-Ming.
Optical coherence tomography: a minimally-invasive
diagnostic tool for patients with AIN.
Degree: MS, Clinical Research, 2013, University of Minnesota
URL: http://purl.umn.edu/160169
► University of Minnesota M.S. thesis. July 2013. Major: Clinical Research. Advisor: Robert D. Madoff, MD. 1 computer file (PDF); vi, 22 pages.
Background: Optical coherence…
(more)
▼ University of Minnesota M.S. thesis. July 2013.
Major: Clinical Research. Advisor: Robert D. Madoff, MD. 1 computer
file (PDF); vi, 22 pages.
Background: Optical coherence tomography (OCT), a
near-infrared imaging technology that produces cross-sectional
images of the internal microstructure of biologic tissues, has
previously been used to detect squamous cell carcinoma, but not
within the anal canal. We hypothesized that OCT could distinguish
between patients with anal intraepithelial neoplasia (AIN) and
controls. Materials and Methods: We obtained OCT images of the anal
canal in 30 patients at high-risk for AIN and 30 controls.
High-risk AIN patients underwent high-resolution anoscopy ± biopsy
to confirm presence or absence of disease. A blinded analyst
measured images for epithelial thickness and brightness. Using
criteria from cervical dysplasia literature, 3 blinded and 2
unblinded colorectal surgeons with no prior OCT experience
evaluated images for presence of AIN. Sensitivity, specificity,
positive predictive value, negative predictive value and kappa
statistic, a measure of intra-rater agreement, were calculated.
Results: OCT was well-tolerated by all patients. AIN patients had a
higher prevalence of immunosuppression (52% vs 13%, p=0.001).
Epithelial thickness and brightness were not significantly
different between groups. Sensitivity for blinded investigators was
8-31% with 85-78% specificity. Sensitivity for unblinded
investigators was 31-77% with 71-75% specificity with a kappa
statistic of 0.11. Conclusions: Interpretation of OCT images by
naïve observers had better sensitivity, specificity, and negative
predictive value when pre-test probability was high. This may
improve with observer experience and advancements in technology.
Further characterization of the anal canal with newer models for
OCT imaging is needed to determine the utility of OCT as a
non-invasive clinical adjunct for detection of
AIN.
Advisors/Committee Members: Robert D. Madoff, MD.
Subjects/Keywords: Anal intraepithelial; Colorectal Surgery; Optical coherence tomography
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APA (6th Edition):
Lee, J. T. (2013). Optical coherence tomography: a minimally-invasive
diagnostic tool for patients with AIN. (Masters Thesis). University of Minnesota. Retrieved from http://purl.umn.edu/160169
Chicago Manual of Style (16th Edition):
Lee, Janet Tien-Ming. “Optical coherence tomography: a minimally-invasive
diagnostic tool for patients with AIN.” 2013. Masters Thesis, University of Minnesota. Accessed January 23, 2021.
http://purl.umn.edu/160169.
MLA Handbook (7th Edition):
Lee, Janet Tien-Ming. “Optical coherence tomography: a minimally-invasive
diagnostic tool for patients with AIN.” 2013. Web. 23 Jan 2021.
Vancouver:
Lee JT. Optical coherence tomography: a minimally-invasive
diagnostic tool for patients with AIN. [Internet] [Masters thesis]. University of Minnesota; 2013. [cited 2021 Jan 23].
Available from: http://purl.umn.edu/160169.
Council of Science Editors:
Lee JT. Optical coherence tomography: a minimally-invasive
diagnostic tool for patients with AIN. [Masters Thesis]. University of Minnesota; 2013. Available from: http://purl.umn.edu/160169
15.
Tona, Yosuke.
In Vivo Imaging of Mouse Cochlea by Optical Coherence Tomography : 光干渉断層計によるマウス蝸牛の生存下での観察.
Degree: 博士(医学), 2016, Kyoto University / 京都大学
URL: http://hdl.handle.net/2433/215400
;
http://dx.doi.org/10.14989/doctor.k19574
Final publication is available at http://journals.lww.com/otology-neurotology/Pages/default.aspx
新制・課程博士
甲第19574号
医博第4081号
Subjects/Keywords: optical coherence tomography; endolymphatic hydrops; Slc26a4
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APA (6th Edition):
Tona, Y. (2016). In Vivo Imaging of Mouse Cochlea by Optical Coherence Tomography : 光干渉断層計によるマウス蝸牛の生存下での観察. (Thesis). Kyoto University / 京都大学. Retrieved from http://hdl.handle.net/2433/215400 ; http://dx.doi.org/10.14989/doctor.k19574
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Tona, Yosuke. “In Vivo Imaging of Mouse Cochlea by Optical Coherence Tomography : 光干渉断層計によるマウス蝸牛の生存下での観察.” 2016. Thesis, Kyoto University / 京都大学. Accessed January 23, 2021.
http://hdl.handle.net/2433/215400 ; http://dx.doi.org/10.14989/doctor.k19574.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Tona, Yosuke. “In Vivo Imaging of Mouse Cochlea by Optical Coherence Tomography : 光干渉断層計によるマウス蝸牛の生存下での観察.” 2016. Web. 23 Jan 2021.
Vancouver:
Tona Y. In Vivo Imaging of Mouse Cochlea by Optical Coherence Tomography : 光干渉断層計によるマウス蝸牛の生存下での観察. [Internet] [Thesis]. Kyoto University / 京都大学; 2016. [cited 2021 Jan 23].
Available from: http://hdl.handle.net/2433/215400 ; http://dx.doi.org/10.14989/doctor.k19574.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Tona Y. In Vivo Imaging of Mouse Cochlea by Optical Coherence Tomography : 光干渉断層計によるマウス蝸牛の生存下での観察. [Thesis]. Kyoto University / 京都大学; 2016. Available from: http://hdl.handle.net/2433/215400 ; http://dx.doi.org/10.14989/doctor.k19574
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Manchester
16.
Dinsdale, Graham.
Optical Coherence Tomography: applications and
developments for imaging in vivo biological tissue.
Degree: 2011, University of Manchester
URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:131341
► The work presented in this thesis was re-submitted to The University of Manchester for the degree of Doctor of Philosophy in July 2011 by Graham…
(more)
▼ The work presented in this thesis was re-submitted
to The University of Manchester for the degree of Doctor of
Philosophy in July 2011 by Graham Dinsdale and is entitled “
Optical
Coherence Tomography: applications and developments for imaging in
vivo biological tissue”.In this thesis the design and build of a
high-speed, video-rate
optical coherence tomography (OCT) imaging
system is described. The system was designed for the purpose of
imaging human skin in vivo, particularly that of patients suffering
from conditions such as systemic sclerosis. Component selection and
design decisions are discussed in the context of the intended final
application. Initial test images from the system are presented. In
the context of building an OCT system, a supercontinuum light
source was characterised and tested for its suitability for use in
the OCT environment. Parameters such as
coherence length were
measured using simple interferometry techniques, while practical
considerations such as portability and ease of system integration
were also considered.Several applications of OCT imaging techniques
were also investigated, using two commercially-available OCT
systems from Thorlabs, Inc. A liquid-based skin and blood flow
model was constructed using narrow glass capillary tubes, pumped
through with scattering solutions of Intralipid or suspensions of
polystyrene microspheres. The concentration of the solutions was
tuned by dilution in order to best model the scattering parameters
of blood. The model also used similar liquid solutions to model
static tissue surrounding the blood vessels. Doppler OCT images of
the model under various conditions were recorded, and velocity
profiles of the flowing liquids were extracted.Using the same
commercial OCT systems, imaging over two separate wavelength
regions was also performed on the skin of several different species
of neo-tropical tree frog, some of which have interesting
reflective properties due to the presence of a pigment called
pterorhodin. Cross-sectional OCT images of the skin are presented,
and averaged depth profiles extracted from them. This is the first
time that OCT imaging has been applied to this problem.A clinical
study of skin thickening and microvascular function in patients
with systemic sclerosis compared to healthy controls was also
carried out, again involving a Thorlabs, Inc. commercial OCT
system. This study was carried out at Salford Royal Hospital under
the supervision of the rheumatology research group. Skin thickness
was assessed using OCT and high-frequency ultrasound imaging.
Microvascular function was measured using nailfold cappilaroscopy
and laser Doppler imaging. Images from the study are presented
here.
Advisors/Committee Members: DICKINSON, MARK MR, MURRAY, ANDREA AK, Dickinson, Mark, Dickinson, Mark, Murray, Andrea, Murray, Andrea.
Subjects/Keywords: laser; broadband; OCT; coherence; imaging; tomography; optical
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Manager
APA (6th Edition):
Dinsdale, G. (2011). Optical Coherence Tomography: applications and
developments for imaging in vivo biological tissue. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:131341
Chicago Manual of Style (16th Edition):
Dinsdale, Graham. “Optical Coherence Tomography: applications and
developments for imaging in vivo biological tissue.” 2011. Doctoral Dissertation, University of Manchester. Accessed January 23, 2021.
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:131341.
MLA Handbook (7th Edition):
Dinsdale, Graham. “Optical Coherence Tomography: applications and
developments for imaging in vivo biological tissue.” 2011. Web. 23 Jan 2021.
Vancouver:
Dinsdale G. Optical Coherence Tomography: applications and
developments for imaging in vivo biological tissue. [Internet] [Doctoral dissertation]. University of Manchester; 2011. [cited 2021 Jan 23].
Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:131341.
Council of Science Editors:
Dinsdale G. Optical Coherence Tomography: applications and
developments for imaging in vivo biological tissue. [Doctoral Dissertation]. University of Manchester; 2011. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:131341
University of Manitoba
17.
Malektaji, Siavash.
Monte Carlo Simulation of Optical Coherence Tomography of Media with Arbitrary Spatial Distributions.
Degree: Electrical and Computer Engineering, 2014, University of Manitoba
URL: http://hdl.handle.net/1993/23931
► Optical Coherence Tomography (OCT) is a sub-surface imaging modality with growing number of applications. An accurate and practical OCT simulator could be an important tool…
(more)
▼ Optical Coherence Tomography (OCT) is a sub-surface imaging modality with growing number of applications. An accurate and practical OCT simulator could be an important tool to understand the physics underlying OCT and to design OCT systems with improved performance. All available OCT simulators are restricted to imaging planar multilayered media or non-planar multilayered media. In this work I developed a novel Monte Carlo based simulator of OCT imaging for turbid media with arbitrary spatial distributions. This simulator allows computation of both Class I diffusive reflectance, due to ballistic and quasi-ballistic scattered photons, and Class II diffusive reflectance due to multiple scattered photons. A tetrahedron-based mesh is used to model any arbitrary-shaped medium to be simulated. I have also implemented a known importance sampling method to significantly reduce computational time of simulations by up to two orders of magnitude. The simulator is verified by comparing its results to results from previously validated OCT simulators for multilayered media. I present sample simulation results for OCT imaging of non-layered media which would not have been possible with earlier simulators.
Advisors/Committee Members: Sherif, Sherif S. (Electrical and Computer Engineering) (supervisor), Yahampath, Pradeepa (Electrical and Computer Engineering) Goertzen, Andrew (Physics and Astronomy) (examiningcommittee).
Subjects/Keywords: Monte Carlo methods; Optical Coherence Tomography
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APA (6th Edition):
Malektaji, S. (2014). Monte Carlo Simulation of Optical Coherence Tomography of Media with Arbitrary Spatial Distributions. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/23931
Chicago Manual of Style (16th Edition):
Malektaji, Siavash. “Monte Carlo Simulation of Optical Coherence Tomography of Media with Arbitrary Spatial Distributions.” 2014. Masters Thesis, University of Manitoba. Accessed January 23, 2021.
http://hdl.handle.net/1993/23931.
MLA Handbook (7th Edition):
Malektaji, Siavash. “Monte Carlo Simulation of Optical Coherence Tomography of Media with Arbitrary Spatial Distributions.” 2014. Web. 23 Jan 2021.
Vancouver:
Malektaji S. Monte Carlo Simulation of Optical Coherence Tomography of Media with Arbitrary Spatial Distributions. [Internet] [Masters thesis]. University of Manitoba; 2014. [cited 2021 Jan 23].
Available from: http://hdl.handle.net/1993/23931.
Council of Science Editors:
Malektaji S. Monte Carlo Simulation of Optical Coherence Tomography of Media with Arbitrary Spatial Distributions. [Masters Thesis]. University of Manitoba; 2014. Available from: http://hdl.handle.net/1993/23931
University of Manitoba
18.
Sobhy, Micheal Ramez Wadee.
Fast simulation of finite-beam optical coherence tomography of inhomogeneous turbid media.
Degree: Biomedical Engineering, 2018, University of Manitoba
URL: http://hdl.handle.net/1993/33533
► We developed a fast simulator of finite-beam optical coherence tomography (OCT) of inhomogeneous turbid media. Our Sequential Monte Carlo (MC) based finite beam OCT simulator…
(more)
▼ We developed a fast simulator of finite-beam
optical coherence tomography (OCT) of inhomogeneous turbid media. Our Sequential Monte Carlo (MC) based finite beam OCT simulator can reach more than a hundred times faster than one that represents a finite OCT’s incident beam as a superposition of infinitely thin beams, i.e., a superposition-based MC simulator. In this thesis, first, we highlight the lesser-known correspondence between the commonly used MC simulation of light in turbid media, and Sequential MC based solution of the Radiative Transfer Equation (RTE). Second, we describe the implementation of our simulator of finite-beam OCT as a Sequential MC solution to the RTE. Third, we derive analytical expressions for the relationship between simulation errors and computational complexities, i.e., simulation times, for both our Sequential MC based simulator and a superposition-based MC simulator. We present simulation results of finite beam OCT of inhomogeneous turbid media when having a finite beam with a Gaussian intensity profile. Our simulator could be used in OCT design since it models realistic beam profiles that are typically used in OCT systems.
Advisors/Committee Members: Sherif, Sherif (Electrical and Computer Engineering) (supervisor), Jeffrey, Ian (Electrical and Computer Engineering).
Subjects/Keywords: Optical Coherence Tomography; Light Simulation in tissue
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APA (6th Edition):
Sobhy, M. R. W. (2018). Fast simulation of finite-beam optical coherence tomography of inhomogeneous turbid media. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/33533
Chicago Manual of Style (16th Edition):
Sobhy, Micheal Ramez Wadee. “Fast simulation of finite-beam optical coherence tomography of inhomogeneous turbid media.” 2018. Masters Thesis, University of Manitoba. Accessed January 23, 2021.
http://hdl.handle.net/1993/33533.
MLA Handbook (7th Edition):
Sobhy, Micheal Ramez Wadee. “Fast simulation of finite-beam optical coherence tomography of inhomogeneous turbid media.” 2018. Web. 23 Jan 2021.
Vancouver:
Sobhy MRW. Fast simulation of finite-beam optical coherence tomography of inhomogeneous turbid media. [Internet] [Masters thesis]. University of Manitoba; 2018. [cited 2021 Jan 23].
Available from: http://hdl.handle.net/1993/33533.
Council of Science Editors:
Sobhy MRW. Fast simulation of finite-beam optical coherence tomography of inhomogeneous turbid media. [Masters Thesis]. University of Manitoba; 2018. Available from: http://hdl.handle.net/1993/33533
Université Catholique de Louvain
19.
Mallat, Kamel.
Novel developments in Fourier domain optical coherence tomography and nonlinear tomographic interferometry.
Degree: 2014, Université Catholique de Louvain
URL: http://hdl.handle.net/2078.1/151822
► In this thesis we present novel methods to improve the limitations in Optical Coherence Tomography (OCT). They are divided into two parts. The first part…
(more)
▼ In this thesis we present novel methods to improve the limitations in Optical Coherence Tomography (OCT). They are divided into two parts. The first part deals with the axial resolution limitation in OCT systems. We give a description of the Fourier Domain OCT (FDOCT), and then we show theoretically how to enhance the axial resolution in a particular case of a two-layer sample where one of the two layers is moving continuously, while these two layers are separated by a distance lower than the physical axial resolution. The second part of the thesis demonstrates a novel full theoretical model that uses the second order autocorrelation interferometry technique in nonlinear optics to eliminate the strong background DC, and therefore enhance the imaging contrast. A femtosecond laser emits the light at 1300nm wavelength, it travels through a polarized beam splitter which divides the light in two orthogonal polarizations, one will probe the reference and the other will probe the sample. By realizing the second harmonic generation, in type II configuration, it is possible to eliminate the DC. The setup is adapted, in an original manner, so as to realize interferometric measurements on the sample arm using three waves coupling. A full description of the method with solid theoretical models justified by simulation and experimental results is presented in this part to validate the proof of concept. This part of the thesis shows the possibility to use non-linear interferometry in order to provide interferometric measurements on a dark field even if strong parasitic light is reflected by the sample.
(SC - Sciences) – UCL, 2014
Advisors/Committee Members: UCL - SST/IMCN/NAPS - Nanoscopic Physics, UCL - Faculté des Sciences, José Luis, Fernandez, Cornet, Alain, Urbain, Xavier, Piraux, Bernard, Francis, Laurent, Marc, Georges, Antoine, Philippe.
Subjects/Keywords: Interferometry; Optical coherence tomography; Nonlinear optic; Imaging
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APA (6th Edition):
Mallat, K. (2014). Novel developments in Fourier domain optical coherence tomography and nonlinear tomographic interferometry. (Thesis). Université Catholique de Louvain. Retrieved from http://hdl.handle.net/2078.1/151822
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mallat, Kamel. “Novel developments in Fourier domain optical coherence tomography and nonlinear tomographic interferometry.” 2014. Thesis, Université Catholique de Louvain. Accessed January 23, 2021.
http://hdl.handle.net/2078.1/151822.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mallat, Kamel. “Novel developments in Fourier domain optical coherence tomography and nonlinear tomographic interferometry.” 2014. Web. 23 Jan 2021.
Vancouver:
Mallat K. Novel developments in Fourier domain optical coherence tomography and nonlinear tomographic interferometry. [Internet] [Thesis]. Université Catholique de Louvain; 2014. [cited 2021 Jan 23].
Available from: http://hdl.handle.net/2078.1/151822.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mallat K. Novel developments in Fourier domain optical coherence tomography and nonlinear tomographic interferometry. [Thesis]. Université Catholique de Louvain; 2014. Available from: http://hdl.handle.net/2078.1/151822
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Manchester
20.
Alwafi, Reem.
Development of optical coherence tomography endoscopy for gynaecological and gastrointestinal studies and peritoneal membrane imaging.
Degree: PhD, 2012, University of Manchester
URL: https://www.research.manchester.ac.uk/portal/en/theses/development-of-optical-coherence-tomography-endoscopy-for-gynaecological-and-gastrointestinal-studies-and-peritoneal-membrane-imaging(8254ec5d-549d-413a-a048-7d773e28dc79).html
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.727780
► In the medical field, the detection and diagnosis of diseases continue to improve. Developments in diagnostic techniques have helped to improve treatment in the early…
(more)
▼ In the medical field, the detection and diagnosis of diseases continue to improve. Developments in diagnostic techniques have helped to improve treatment in the early stages and avoid many risks to patients. One relatively new diagnostic technique is optical coherence tomography (OCT), which is used in many medical applications to perform internal microstructure imaging of the human body at high resolution (typically 10 micro metre), at high speed and in real time. OCT is non-invasive and can be used as a contact or non-contact technique to obtain an image. In medicine, there are many applications that involve OCT, such as in ophthalmology, gastroenterology, cardiology and oncology. This work demonstrates the design, development and implementation of a high resolution swept laser OCT system for the imaging and diagnosis of tissues in laboratory and clinical experiments. It reports an investigation to measure the thickness of the peritoneal membrane and the use of optical imaging contrast agents such as gold nanorods. There is also an account of the design of an endoscope-catheter fast scanning OCT system for biomedical studies of the gastrointestinal tract and gynaecological areas. These results were achieved by using a swept tuneable laser source with a very high tuning speed of 16 kHz over a wide range of wavelengths: 1260 nm to 1390 nm. The laser sweeps across 110 nm at a 16 kHz repetition rate. The real axial line speed is limited by the source that is used in the OCT system. The axial resolution of the system is 7 µm and its transverse resolution is 15 µm. The bandwidth of the source is up to DeltaGamma = 110 nm, centred at Gamma0 = 1325 nm, and the coherent length is 7 µm. On the sample arm of the interferometer, the swept laser OCT technique is combined with an optical probe and endoscope in order to develop a novel diagnostic imaging device to visualize tissue in vivo for animal and human experimental trials.
Subjects/Keywords: 616.07; Medical imaging techniques; Optical coherence tomography
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APA (6th Edition):
Alwafi, R. (2012). Development of optical coherence tomography endoscopy for gynaecological and gastrointestinal studies and peritoneal membrane imaging. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/development-of-optical-coherence-tomography-endoscopy-for-gynaecological-and-gastrointestinal-studies-and-peritoneal-membrane-imaging(8254ec5d-549d-413a-a048-7d773e28dc79).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.727780
Chicago Manual of Style (16th Edition):
Alwafi, Reem. “Development of optical coherence tomography endoscopy for gynaecological and gastrointestinal studies and peritoneal membrane imaging.” 2012. Doctoral Dissertation, University of Manchester. Accessed January 23, 2021.
https://www.research.manchester.ac.uk/portal/en/theses/development-of-optical-coherence-tomography-endoscopy-for-gynaecological-and-gastrointestinal-studies-and-peritoneal-membrane-imaging(8254ec5d-549d-413a-a048-7d773e28dc79).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.727780.
MLA Handbook (7th Edition):
Alwafi, Reem. “Development of optical coherence tomography endoscopy for gynaecological and gastrointestinal studies and peritoneal membrane imaging.” 2012. Web. 23 Jan 2021.
Vancouver:
Alwafi R. Development of optical coherence tomography endoscopy for gynaecological and gastrointestinal studies and peritoneal membrane imaging. [Internet] [Doctoral dissertation]. University of Manchester; 2012. [cited 2021 Jan 23].
Available from: https://www.research.manchester.ac.uk/portal/en/theses/development-of-optical-coherence-tomography-endoscopy-for-gynaecological-and-gastrointestinal-studies-and-peritoneal-membrane-imaging(8254ec5d-549d-413a-a048-7d773e28dc79).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.727780.
Council of Science Editors:
Alwafi R. Development of optical coherence tomography endoscopy for gynaecological and gastrointestinal studies and peritoneal membrane imaging. [Doctoral Dissertation]. University of Manchester; 2012. Available from: https://www.research.manchester.ac.uk/portal/en/theses/development-of-optical-coherence-tomography-endoscopy-for-gynaecological-and-gastrointestinal-studies-and-peritoneal-membrane-imaging(8254ec5d-549d-413a-a048-7d773e28dc79).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.727780
University of Missouri – Columbia
21.
Zhang, Miao.
Towards high speed high sensitivity optical coherence tomography for in vivo functional imaging.
Degree: 2015, University of Missouri – Columbia
URL: http://hdl.handle.net/10355/47077
► [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Optical coherence tomography (OCT) is an imaging technique that has been widely used in…
(more)
▼ [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.]
Optical coherence tomography (OCT) is an imaging technique that has been widely used in clinics and industrial fields. This dissertation, making use of several emerging techniques, works on improving the imaging speed and sensitivity of current OCT systems so that it will be more powerful in imaging biological tissues, live animals and human patients. Dual-band Fourier domain OCT (FD-OCT) has the potential to provide high quality images that can differentiate different types of tissues. However, previous dual-band FD-OCT systems could not give correct information due to inherited limitations in imaging system setup, sample properties and theory. Our new imaging system overcomes these limitations by using unique hardware and software design. In our imaging system, different false signals are suppressed and the signal attenuation due to samples are compensated using proposed algorithms that derived from theoretical analysis. A video card is used to process data in an ultrahigh speed. With high imaging speed we are able to imaging live animals despite the movement of subjects. The high speed also makes it possible to display the imaging volume interactively in 3D. The image quality and information contained in the images are improved. We further developed an OCT imaging system using a special kind of
optical beam called finite energy Airy beam. Compared to OCT system using traditional
optical beams, Airy beam OCT has the potential to view a much longer range and view deeper inside the biological tissue.
Advisors/Committee Members: Yu, Ping (advisor).
Subjects/Keywords: Optical coherence tomography; Tissues – Imaging; Interferometry; Medicine
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APA (6th Edition):
Zhang, M. (2015). Towards high speed high sensitivity optical coherence tomography for in vivo functional imaging. (Thesis). University of Missouri – Columbia. Retrieved from http://hdl.handle.net/10355/47077
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Zhang, Miao. “Towards high speed high sensitivity optical coherence tomography for in vivo functional imaging.” 2015. Thesis, University of Missouri – Columbia. Accessed January 23, 2021.
http://hdl.handle.net/10355/47077.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Zhang, Miao. “Towards high speed high sensitivity optical coherence tomography for in vivo functional imaging.” 2015. Web. 23 Jan 2021.
Vancouver:
Zhang M. Towards high speed high sensitivity optical coherence tomography for in vivo functional imaging. [Internet] [Thesis]. University of Missouri – Columbia; 2015. [cited 2021 Jan 23].
Available from: http://hdl.handle.net/10355/47077.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Zhang M. Towards high speed high sensitivity optical coherence tomography for in vivo functional imaging. [Thesis]. University of Missouri – Columbia; 2015. Available from: http://hdl.handle.net/10355/47077
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Illinois – Urbana-Champaign
22.
Shin, Sunghwan.
Characterization and comparison of optical source relative intensity noise and effects in optical coherence tomography.
Degree: MS, 1200, 2011, University of Illinois – Urbana-Champaign
URL: http://hdl.handle.net/2142/18570
► This thesis research investigates the effects of optical source noise in optical coherence tomography (OCT). While shot noise, thermal noise and relative intensity noise (RIN)…
(more)
▼ This thesis research investigates the effects of
optical source noise in
optical coherence tomography (OCT). While shot noise, thermal noise and relative intensity noise (RIN) (excess photon noise) constitute
optical noise, RIN is the least understood and often the most significant factor limiting the sensitivity of an
optical system. The existing and prevalent theory being used for estimating RIN for various light sources in OCT is questionable, and cannot be applied uniformly for different types of sources. The origin of noise in various sources varies significantly, owing to the different physical nature of photon generation. In this thesis, RIN of several OCT light sources are characterized and compared. Light sources include a super-luminescent diode (SLD), an erbium-doped fiber amplifier (EDFA), multiplexed SLDs, and a continuous wave (cw) laser. A method for the reduction of RIN by amplifying the SLD light output by using a gain-saturated semiconductor
optical amplifier (SOA) is reported. Also, measurements using a time-domain OCT (TD-OCT) system are performed to verify the effects of
optical source noise reduction on OCT data. Simulations comparing OCT and ISAM images assuming an identical
optical source noise are also performed and explained.
Advisors/Committee Members: Boppart, Stephen A. (advisor).
Subjects/Keywords: optical coherence tomography; relative intensity noise
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APA (6th Edition):
Shin, S. (2011). Characterization and comparison of optical source relative intensity noise and effects in optical coherence tomography. (Thesis). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/18570
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Shin, Sunghwan. “Characterization and comparison of optical source relative intensity noise and effects in optical coherence tomography.” 2011. Thesis, University of Illinois – Urbana-Champaign. Accessed January 23, 2021.
http://hdl.handle.net/2142/18570.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Shin, Sunghwan. “Characterization and comparison of optical source relative intensity noise and effects in optical coherence tomography.” 2011. Web. 23 Jan 2021.
Vancouver:
Shin S. Characterization and comparison of optical source relative intensity noise and effects in optical coherence tomography. [Internet] [Thesis]. University of Illinois – Urbana-Champaign; 2011. [cited 2021 Jan 23].
Available from: http://hdl.handle.net/2142/18570.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Shin S. Characterization and comparison of optical source relative intensity noise and effects in optical coherence tomography. [Thesis]. University of Illinois – Urbana-Champaign; 2011. Available from: http://hdl.handle.net/2142/18570
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Illinois – Urbana-Champaign
23.
Crecea, Vasilica.
Magnetomotive optical coherence elastography for biomedical applications.
Degree: PhD, Physics, 2015, University of Illinois – Urbana-Champaign
URL: http://hdl.handle.net/2142/89173
► This thesis presents a new non-invasive optical method for assessing biomechanical properties of tissues and cells in real time and with micron scale resolution, magnetomotive…
(more)
▼ This thesis presents a new non-invasive
optical method for assessing biomechanical properties of tissues and cells in real time and with micron scale resolution, magnetomotive
optical coherence elastography (MM-OCE). Biomechanical properties are important because they relate to the tissues’ state of health and they can be utilized for monitoring changes due to pathological processes or therapeutic treatments. In
optical coherence tomography (OCT), the imaging technique that MM-OCE is based on, near infrared light penetrates a few millimeters into highly scattering biological tissues and the backscattered light is detected in real time with interferometry. Post-processing of the
optical signal renders structural images and displacement maps of dynamic processes within the specimens, which contain information about the mechanical signature of the tissues or cells. MM-OCE utilizes magnetic nanoparticles or microspheres that are embedded in the samples of interest, and which induce motion in the samples in the presence of an external magnetic field produced by a custom built solenoid coil. Three studies are presented: the first one introduces the MM-OCE technology and demonstrates its feasibility and versatility on a set of tissue-mimicking silicone phantoms, the second one applies MM-OCE to excised rabbit tissues and reveals their intricate biomechanical behavior, and the third one explores the possibility of extending the technique to the study of cells. Finally, I discuss aspects of this work that can be further advanced by future modeling of the biomechanical properties of different types of soft tissue.
Advisors/Committee Members: Boppart, Stephen (advisor), Stack, John (Committee Chair), Dahmen, Karin (committee member), Popescu, Gabriel (committee member).
Subjects/Keywords: Optical coherence tomography; Elastography; Magnetic nanoparticles; Microspheres
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APA (6th Edition):
Crecea, V. (2015). Magnetomotive optical coherence elastography for biomedical applications. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/89173
Chicago Manual of Style (16th Edition):
Crecea, Vasilica. “Magnetomotive optical coherence elastography for biomedical applications.” 2015. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed January 23, 2021.
http://hdl.handle.net/2142/89173.
MLA Handbook (7th Edition):
Crecea, Vasilica. “Magnetomotive optical coherence elastography for biomedical applications.” 2015. Web. 23 Jan 2021.
Vancouver:
Crecea V. Magnetomotive optical coherence elastography for biomedical applications. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2015. [cited 2021 Jan 23].
Available from: http://hdl.handle.net/2142/89173.
Council of Science Editors:
Crecea V. Magnetomotive optical coherence elastography for biomedical applications. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2015. Available from: http://hdl.handle.net/2142/89173
University of Minnesota
24.
Lee, Janet Tien-Ming.
Optical coherence tomography: a minimally-invasive diagnostic tool for patients with AIN.
Degree: MS, Clinical Research, 2013, University of Minnesota
URL: http://purl.umn.edu/160169
► Background: Optical coherence tomography (OCT), a near-infrared imaging technology that produces cross-sectional images of the internal microstructure of biologic tissues, has previously been used to…
(more)
▼ Background: Optical coherence tomography (OCT), a near-infrared imaging technology that produces cross-sectional images of the internal microstructure of biologic tissues, has previously been used to detect squamous cell carcinoma, but not within the anal canal. We hypothesized that OCT could distinguish between patients with anal intraepithelial neoplasia (AIN) and controls.
Materials and Methods: We obtained OCT images of the anal canal in 30 patients at high-risk for AIN and 30 controls. High-risk AIN patients underwent high-resolution anoscopy ± biopsy to confirm presence or absence of disease. A blinded analyst measured images for epithelial thickness and brightness. Using criteria from cervical dysplasia literature, 3 blinded and 2 unblinded colorectal surgeons with no prior OCT experience evaluated images for presence of AIN. Sensitivity, specificity, positive predictive value, negative predictive value and kappa statistic, a measure of intra-rater agreement, were calculated.
Results: OCT was well-tolerated by all patients. AIN patients had a higher prevalence of immunosuppression (52% vs 13%, p=0.001). Epithelial thickness and brightness were not significantly different between groups. Sensitivity for blinded investigators was 8-31% with 85-78% specificity. Sensitivity for unblinded investigators was 31-77% with 71-75% specificity with a kappa statistic of 0.11. Conclusions: Interpretation of OCT images by naïve observers had better sensitivity, specificity, and negative predictive value when pre-test probability was high. This may improve with observer experience and advancements in technology. Further characterization of the anal canal with newer models for OCT imaging is needed to determine the utility of OCT as a non-invasive clinical adjunct for detection of AIN.
Subjects/Keywords: Anal intraepithelial; Colorectal Surgery; Optical coherence tomography
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APA (6th Edition):
Lee, J. T. (2013). Optical coherence tomography: a minimally-invasive diagnostic tool for patients with AIN. (Masters Thesis). University of Minnesota. Retrieved from http://purl.umn.edu/160169
Chicago Manual of Style (16th Edition):
Lee, Janet Tien-Ming. “Optical coherence tomography: a minimally-invasive diagnostic tool for patients with AIN.” 2013. Masters Thesis, University of Minnesota. Accessed January 23, 2021.
http://purl.umn.edu/160169.
MLA Handbook (7th Edition):
Lee, Janet Tien-Ming. “Optical coherence tomography: a minimally-invasive diagnostic tool for patients with AIN.” 2013. Web. 23 Jan 2021.
Vancouver:
Lee JT. Optical coherence tomography: a minimally-invasive diagnostic tool for patients with AIN. [Internet] [Masters thesis]. University of Minnesota; 2013. [cited 2021 Jan 23].
Available from: http://purl.umn.edu/160169.
Council of Science Editors:
Lee JT. Optical coherence tomography: a minimally-invasive diagnostic tool for patients with AIN. [Masters Thesis]. University of Minnesota; 2013. Available from: http://purl.umn.edu/160169
University of Illinois – Urbana-Champaign
25.
Xu, Yang.
Information extraction algorithms based on optical coherence tomography data.
Degree: PhD, Electrical & Computer Engr, 2017, University of Illinois – Urbana-Champaign
URL: http://hdl.handle.net/2142/99193
► In this dissertation, we present several algorithms developed for optical coherence tomography (OCT) datasets. We show that by incorporating physical modeling, mathematical analysis and signal…
(more)
▼ In this dissertation, we present several algorithms developed for
optical coherence tomography (OCT) datasets. We show that by incorporating physical modeling, mathematical analysis and signal processing, it is possible to uncover the huge potential hidden in the raw OCT data. The automated Interferometric Synthetic Aperture Microscopy algorithm uses image sharpness metrics to automatically search for the optimal parameters for each step of the processing, resulting in near-optimal reconstruction comparable to images manually tuned by experts. The filtering algorithm for Doppler OCT images combines mathematical optimization with GPU parallel programming, and drastically increases the dynamic range of Doppler OCT velocity maps, making Doppler OCT potentially applicable to faster blood vessels such as the carotids. The susceptibility tensor ISAM algorithm converts the complicated multipolarization scattering and detection problem into a linear algebra problem and solves it through regularized least square method, which enables us to indirectly measure all nine components of the susceptibility tensor for clusters of discrete particles. We also discuss the potential method to extend susceptibility tensor ISAM to continuous samples, which promises better contrast between tissue types and insights into the anisotropic structure inside biological tissue.
Advisors/Committee Members: Carney, P. Scott (advisor), Carney, P. Scott (Committee Chair), Eden, J. Gary (committee member), Singer, Andrew C. (committee member), Oelze, Michael L. (committee member), Gruev, Viktor (committee member).
Subjects/Keywords: Optical coherence tomography; Interferometric synthetic aperture microscopy
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to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Xu, Y. (2017). Information extraction algorithms based on optical coherence tomography data. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/99193
Chicago Manual of Style (16th Edition):
Xu, Yang. “Information extraction algorithms based on optical coherence tomography data.” 2017. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed January 23, 2021.
http://hdl.handle.net/2142/99193.
MLA Handbook (7th Edition):
Xu, Yang. “Information extraction algorithms based on optical coherence tomography data.” 2017. Web. 23 Jan 2021.
Vancouver:
Xu Y. Information extraction algorithms based on optical coherence tomography data. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2017. [cited 2021 Jan 23].
Available from: http://hdl.handle.net/2142/99193.
Council of Science Editors:
Xu Y. Information extraction algorithms based on optical coherence tomography data. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2017. Available from: http://hdl.handle.net/2142/99193
University of Southern California
26.
Tokayer, Jason Michael.
Contributions to structural and functional retinal imaging
via Fourier domain optical coherence tomography.
Degree: PhD, Electrical Engineering, 2013, University of Southern California
URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/334273/rec/1638
► Optical coherence tomography (OCT) is a depth-resolved cross-sectional imaging modality capable of imaging biological tissue at the micron-scale in vivo. OCT has found widespread use…
(more)
▼ Optical coherence tomography (OCT) is a depth-resolved
cross-sectional imaging modality capable of imaging biological
tissue at the micron-scale in vivo. OCT has found widespread use in
ophthalmology because of the translucent nature of retinal tissue
as well as OCT's high resolution and non-contact implementation.
OCT is analogous to ultrasound, except that it uses light instead
of sound to illuminate a sample. OCT measures travel time of light
that is backscattered from structures at different depths or axial
distances (axial scans) within the sample. Cross-sectional images
are generated by scanning the
optical beam in the transverse
direction and performing successive axial scan measurements. ❧
Structural imaging of the human retina has provided new insights
into ophthalmic disease. For example, retinal nerve fiber layer
thickness is utilized in glaucoma progression analysis. Thus,
segmentation of OCT retinal images, which is complicated by low
image contrast and high levels of speckle noise, is crucial for the
study and diagnosis of ocular diseases. Measurement of retinal
blood flow is also important for the study of many ocular
pathologies including glaucoma and diabetic retinopathy. Doppler
OCT, which utilizes measured Doppler frequency/phase shifts to
infer blood flow speed, has consequently found widespread use in
the ophthalmic community. The Doppler effect is only sensitive to
movement along the incident beam's axis. In the case of the human
macular region, however, many blood vessels are nearly
perpendicular to the incident beam, which makes the measured
Doppler frequency shifts small and difficult to detect. For this
reason, measurement of blood flow in the macula using Doppler OCT
is a challenging task. ❧ This thesis encompasses contributions to
both structural and functional OCT retinal imaging. One common
theme found throughout this thesis is the generation of synthetic
or simulated OCT data in order to quantitatively evaluate various
image processing algorithms. For each simulation application the
synthetic data is first validated against in vivo retinal data or
in vitro experimental data and then used to extrapolate the results
and draw inferences about algorithm performance. ❧ We first design
and implement a novel sparsity-based retinal layer segmentation
algorithm that identifies the boundaries between retinal layers in
OCT structural images. In contrast to most state of the art retinal
layer segmentation algorithms, our algorithm does not require
overly restrictive a priori assumptions about the expected layer
structure and can thus possibly be used to detect unexpected
structures that arise in pathological cases. One difficulty with
quantitative evaluation of segmentation algorithms applied to in
vivo retinal images is that the ground truth segmentation is not
known. Motivated by this fact, we design a novel method for
generating synthetic structural retinal images for which the ground
truth segmentation is known. Our technique improves upon an
existing synthetic image generation method both by…
Advisors/Committee Members: Ortega, Antonio K.Huang, David (Committee Chair), Jenkins, Brian Keith (Committee Member), Mel, Bartlett W. (Committee Member).
Subjects/Keywords: optical coherence tomography; biomedical image processing
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APA (6th Edition):
Tokayer, J. M. (2013). Contributions to structural and functional retinal imaging
via Fourier domain optical coherence tomography. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/334273/rec/1638
Chicago Manual of Style (16th Edition):
Tokayer, Jason Michael. “Contributions to structural and functional retinal imaging
via Fourier domain optical coherence tomography.” 2013. Doctoral Dissertation, University of Southern California. Accessed January 23, 2021.
http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/334273/rec/1638.
MLA Handbook (7th Edition):
Tokayer, Jason Michael. “Contributions to structural and functional retinal imaging
via Fourier domain optical coherence tomography.” 2013. Web. 23 Jan 2021.
Vancouver:
Tokayer JM. Contributions to structural and functional retinal imaging
via Fourier domain optical coherence tomography. [Internet] [Doctoral dissertation]. University of Southern California; 2013. [cited 2021 Jan 23].
Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/334273/rec/1638.
Council of Science Editors:
Tokayer JM. Contributions to structural and functional retinal imaging
via Fourier domain optical coherence tomography. [Doctoral Dissertation]. University of Southern California; 2013. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/334273/rec/1638
University of Hong Kong
27.
徐鉴冰.
Optical coherence
tomography : from system design to spectroscopic
applications.
Degree: 2014, University of Hong Kong
URL: http://hdl.handle.net/10722/206473
► Optical coherence tomography (OCT), as a newly developed imaging modality, has attracted significant attention due to its capability to obtain the cross-sectional information of biological…
(more)
▼ Optical coherence tomography (OCT), as a newly
developed imaging modality, has attracted significant attention due
to its capability to obtain the cross-sectional information of
biological tissues in a non-invasive way, with resolution in the
range of several micrometers. The third-generation swept source OCT
(SS-OCT), is superior in the speed, imaging range and
signal-to-noise ratio (SNR) compared with the previous time-domain
OCT (TD-OCT) and spectral domain OCT (SD-OCT), and therefore forms
our research focus.
In this thesis, for the first time, I
investigate the deployment of Fourier domain mode-locked (FDML)
swept laser by utilizing the bismuth-based erbium doper fiber
(Bi-EDF) with a sweeping bandwidth of ~ 81nm achieved. Following,
fiber Raman amplifier (FRA) is also investigated by employing
multiple Raman pumps. The tuning range is ~111.8nm, which is much
larger than the previous reported Raman pumped FDML in the 1550nm
region. Imaging was performed to validate the feasibility of the
proposed schemes for the SS-OCT applications, respectively.
In
addition to the FDML swept laser cavity design, speckle noise
reduction is also of great importance in OCT, which can
significantly improve the visibility of the obtained OCT images. I
demonstrate two different speckle reduction methods for OCT
applications, which are superior in suppressing speckle noise and
reserving the one-dimensional (1D) and two-dimensional (2D) signal
information, respectively. Applying the proposed wavelet domain
compounding (WDC) and contourlet shrinkage method to despeckle the
OCT images, the visibility of the OCT images was significantly
improved, with negligible edge preservation compromise.
Spectroscopic information is also of interest to many researchers
as it provides additional spectroscopic contrast, which on one
hand, will improve the visualization of the images, and on the
other hand, will enable the classification of different tissue
types and help the process of discrimination between invasive and
noninvasive tumors. Compared with our previous reported work about
dual-band spectroscopic OCT based on
optical parametric amplifier
(OPA) to generate another idler band, which will be used as the
second band for dual-band spectroscopic analysis, I further extend
the dual-band spectroscopic OCT to the endoscopic applications, and
investigate the dual-band FDML swept laser configuration based on a
custom-designed dual-channel driver to synchronize the two
different wavelength bands, centered at 1310 and 1550 nm,
respectively. OCT Images for different bands are captured and
post-processed by coding the spectral difference in different
colors.
In short, in this thesis, the investigations of OCT
range from system design, speckle reduction to the spectroscopic
applications. All these research efforts will extend the current
FDML techniques for a wide range of SS-OCT applications. These
schemes may be useful in OCT swept laser source build up, speckle
noise reduction, and the extension of spectroscopic
analysis.
Advisors/Committee Members: Lam, EYM (advisor), Wong, KKY (advisor).
Subjects/Keywords: Optical
coherence tomography
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
徐鉴冰. (2014). Optical coherence
tomography : from system design to spectroscopic
applications. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/206473
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
徐鉴冰. “Optical coherence
tomography : from system design to spectroscopic
applications.” 2014. Thesis, University of Hong Kong. Accessed January 23, 2021.
http://hdl.handle.net/10722/206473.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
徐鉴冰. “Optical coherence
tomography : from system design to spectroscopic
applications.” 2014. Web. 23 Jan 2021.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Vancouver:
徐鉴冰. Optical coherence
tomography : from system design to spectroscopic
applications. [Internet] [Thesis]. University of Hong Kong; 2014. [cited 2021 Jan 23].
Available from: http://hdl.handle.net/10722/206473.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
徐鉴冰. Optical coherence
tomography : from system design to spectroscopic
applications. [Thesis]. University of Hong Kong; 2014. Available from: http://hdl.handle.net/10722/206473
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
University of Hong Kong
28.
陳俊弘.
Statistical estimation of
haemodynamic parameters in optical coherence tomography.
Degree: 2014, University of Hong Kong
URL: http://hdl.handle.net/10722/206460
► Optical coherence tomography (OCT) is an imaging modality analogous to ultrasound. By using the interference properties of light, one may image to micrometer resolutions using…
(more)
▼ Optical coherence tomography (OCT) is an
imaging modality analogous to ultrasound. By using the interference
properties of light, one may image to micrometer resolutions using
interferometric methods. Most modern systems can acquire A-scans at
kHz to MHz speeds, and are capable of real-time 3D imaging. OCT has
been used extensively in ophthalmology and has been used in
angiography to quantify blood flow. The aim of this research has
been to develop statistically optimal estimators for blood flow
estimation to take advantage of these hardware advances. This is
achieved through a deeper understanding of the noise
characteristics of OCT. Through mathematical derivations and
simulations, the noise characteristics of OCT Doppler and flow
imaging were accurately modelled as additive white noise and
multiplicative decorrelation noise. Decorrelation arises due to
relative motion of tissue relative to the OCT region of interest
and adversely affects Doppler estimation. From these models maximum
likelihood estimators (MLEs) that statistically outperform the
commonly used Kasai autocorrelation estimator were derived. The
Cramer-Rao lower bound (CRLB), which gives the theoretical lowest
estimator variance for an unbiased estimator was derived for
different noise regimes. It is shown that the AWGN MLE achieves the
CRLB for additive white noise dominant conditions, and the
decorrelation noise MLE achieves the CRLB under more general noise
conditions. The use of computational algorithms that enhance the
capabilities of OCT are demonstrated. This shows that this approach
for determining parametric estimators may be used in a more general
medical imaging context. In addition, the use of decorrelation as a
measure of speed is explored, as it is itself proportional to flow
speed.
Advisors/Committee Members: Zhang, Z (advisor), Chan, SC (advisor).
Subjects/Keywords: Optical
coherence tomography
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APA ·
Chicago ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
陳俊弘. (2014). Statistical estimation of
haemodynamic parameters in optical coherence tomography. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/206460
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
陳俊弘. “Statistical estimation of
haemodynamic parameters in optical coherence tomography.” 2014. Thesis, University of Hong Kong. Accessed January 23, 2021.
http://hdl.handle.net/10722/206460.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
陳俊弘. “Statistical estimation of
haemodynamic parameters in optical coherence tomography.” 2014. Web. 23 Jan 2021.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Vancouver:
陳俊弘. Statistical estimation of
haemodynamic parameters in optical coherence tomography. [Internet] [Thesis]. University of Hong Kong; 2014. [cited 2021 Jan 23].
Available from: http://hdl.handle.net/10722/206460.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
陳俊弘. Statistical estimation of
haemodynamic parameters in optical coherence tomography. [Thesis]. University of Hong Kong; 2014. Available from: http://hdl.handle.net/10722/206460
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
University of Waterloo
29.
Puvanathasan, Prabakar.
Improved image speckle noise reduction and novel dispersion cancellation in Optical Coherence Tomography.
Degree: 2008, University of Waterloo
URL: http://hdl.handle.net/10012/4039
► Optical coherence tomography (OCT) is an innovative modern biomedical imaging technology that allows in-vivo, non-invasive imaging of biological tissues. At present, some of the major…
(more)
▼ Optical coherence tomography (OCT) is an innovative modern biomedical imaging technology that allows in-vivo, non-invasive imaging of biological tissues. At present, some of the major challenges in OCT include the need for fast data acquisition system for probing fast developing biochemical processes in biological tissue, for image processing algorithms to reduce speckle noise and to remove motion artefacts, and for dispersion compensation to improve axial resolution and image contrast. To address the need for fast data acquisition, a novel, high speed (47,000 A-scans/s), ultrahigh axial resolution (3.3μm) Fourier Domain Optical Coherence Tomography (FD-OCT) system in the 1060nm wavelength region has been built at the University of Waterloo. The system provides 3.3μm image resolution in biological tissue and maximum sensitivity of 110 dB. Retinal tomograms acquired in-vivo from a human volunteer and a rat animal model show clear visualization of all intra-retinal layers and increased penetration into the choroid. OCT is based on low-coherence light interferometry. Thus, image quality is dependent on the spatial and temporal coherence properties of the optical waves back-scattered from the imaged object. Due to the coherent nature of light, OCT images are contaminated with speckle noise. Two novel speckle noise reduction algorithms based on interval type II fuzzy sets has been developed to improve the quality of the OCT images. One algorithm is a combination of anisotropic diffusion and interval type II fuzzy system while the other algorithm is based on soft thresholding wavelet coefficients using interval type II fuzzy system. Application of these novel algorithms to Cameraman test image corrupted with speckle noise (variance=0.1) resulted in a root mean square error (RMSE) of 0.07 for both fuzzy anisotropic diffusion and fuzzy wavelet algorithms. This value is less compared to the results obtained for Wiener (RMSE=0.09), adaptive Lee (RMSE=0.09), and median (RMSE=0.12) filters. Applying the algorithms to optical coherence tomograms acquired in-vivo from a human finger-tip show reduction in the speckle noise and image SNR improvement of ~13dB for fuzzy anisotropic diffusion and ~11db for fuzzy wavelet. Comparison with the Wiener (SNR improvement of ~3dB), adaptive Lee (SNR improvement of ~5dB) and median (SNR improvement of ~5dB) filters, applied to the same images, demonstrates the better performance of the fuzzy type II algorithms in terms of image metrics improvement. Micrometer scale OCT image resolution is obtained via use of broad bandwidth light sources. However, the large spectral bandwidth of the imaging beam results in broadening of the OCT interferogram because of the dispersive properties of the imaged objects. This broadening causes deterioration of the axial resolution and as well as loss of contrast in OCT images. A novel even-order dispersion cancellation interferometry via a linear, classical interferometer has been developed which can be further expanded to dispersion canceled OCT.
Subjects/Keywords: optical coherence tomography
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Puvanathasan, P. (2008). Improved image speckle noise reduction and novel dispersion cancellation in Optical Coherence Tomography. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/4039
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Puvanathasan, Prabakar. “Improved image speckle noise reduction and novel dispersion cancellation in Optical Coherence Tomography.” 2008. Thesis, University of Waterloo. Accessed January 23, 2021.
http://hdl.handle.net/10012/4039.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Puvanathasan, Prabakar. “Improved image speckle noise reduction and novel dispersion cancellation in Optical Coherence Tomography.” 2008. Web. 23 Jan 2021.
Vancouver:
Puvanathasan P. Improved image speckle noise reduction and novel dispersion cancellation in Optical Coherence Tomography. [Internet] [Thesis]. University of Waterloo; 2008. [cited 2021 Jan 23].
Available from: http://hdl.handle.net/10012/4039.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Puvanathasan P. Improved image speckle noise reduction and novel dispersion cancellation in Optical Coherence Tomography. [Thesis]. University of Waterloo; 2008. Available from: http://hdl.handle.net/10012/4039
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
30.
Karantalis, Vasileios.
Μηχανισμοί εμφράγματος που αποδίδεται σε θρόμβωση ενδοστεφανιαίας ενδοπρόσθεσης (STENT) με τη χρήση της οπτικής συνετικής τομογραφίας.
Degree: 2015, University of Patras; Πανεπιστήμιο Πατρών
URL: http://hdl.handle.net/10442/hedi/36022
► Acute myocardial infarction (MI) occurring late following stenting may be related to either the stent or disease progression at the same or other coronary arteries.1…
(more)
▼ Acute myocardial infarction (MI) occurring late following stenting may be related to either the stent or disease progression at the same or other coronary arteries.1 Stent-related MI involves stent thrombosis, with or without restenosis. Pathologic and intravascular ultrasoundstudies have shown that delayed healing with incomplete neointimal tissue strut coverage, vessel remodeling, and inflammation constitutes the most frequent substrate of late and verylate drug-eluting stent (DES) thrombosis (LST). Prospective angioscopic and optical coherence tomography (OCT) studies have shown that features possibly associated with DES-LST, such as uncovered stent struts, may be found very frequently, even late post-stenting, depending on the type of DES. However, the reported rate of clinical LST is much lower thanthe reported rate of uncovered DES struts, underlining the fact that this phenomenon is multifactorial and questioning the relevance of the abovementioned OCT findings in prospective studies without clinical events.On the other hand, LST also happens following bare metal stent (BMS) implantation and may have different chronology and mechanisms, as delayed healing is not an issue with thesestents. Very recently, some case series and studies using intracoronary imaging in patients with late clinical events following BMS implantation are suggesting that developmentof new atherosclerotic lesions inside the BMS may be a possible mechanism explaining late events. More intriguing is the fact that features possibly indicative of neointimal“atherosclerotic transformation” have been found also inside DES and questions exist regarding its possible role in LST
Η στεφανιαία αγγειογραφία είναι σήμερα η βασική τεχνική για την εκτίμηση της νόσου των στεφανιαίων αρτηριών. Ωστόσο, αυτή η τεχνική περιορίζεται σε μία δισδιάστατη αναπαράσταση του περιγράμματος του αυλού , χωρίς να παρέχει πληροφορίες σχετικά με το τοίχωμα του αγγείου, το οποίο είναι το υπόστρωμα της αθηροσκλήρωσης. Αυτός ο περιορισμός οδήγησε στην ανάπτυξη νέων τεχνικών ενδοστεφανιαίας άμεσης απεικόνισης της αθηρωματικής πλάκας. Η ανάπτυξη της ενδαγγειακής υπερηχογραφίας (IVUS), επέτρεψε την πολύ πιο λεπτομερή αξιολόγηση της στεφανιαίας αθηροσκλήρωσης , αλλά η περιορισμένη ανάλυση (150-200 μm) απέκλειε την πιο ακριβή απεικόνιση ορισμένων μικροδομών.Η οπτική συνεκτική τομογραφία (OCT) είναι μια βασισμένη στο υπέρυθρο φως απεικονιστική τεχνολογία που παρέχει την δυνατότητα εικόνων in vivo υψηλής ανάλυσης (10-20 μm) της στεφανιαίας αρτηρίας δέκα φορές υψηλότερες από ό, τι η IVUS , αλλά με μια διείσδυση στο αγγειακό τοίχωμα που περιορίζεται σε 1,5-2 mm.Το οξύ έμφραγμα του μυοκαρδίου (ΟΕΜ) που συμβαίνει καθυστερημένα μετά από την εμφύτευση ενδοστεφανιαίας ενδοπρόθεσης μπορεί να σχετίζεται είτε με την ενδοπρόθεση ή την εξέλιξης της αθηρωματικής νόσου στην ίδια ή άλλη στεφανιαία αρτηρία. ΟΕΜ που σχετίζονται με ενδοπρόθεση περιλαμβάνουν θρόμβωση ενδοπρόθεσης με ή χωρίς επαναστένωση. Ιστολογικές και ενδαγγειακές απεικονιστικές μελέτες υπερήχων έδειξαν ότι η καθυστερημένη…
Subjects/Keywords: Οπτική συνεκτική τομογραφία; Optical coherence tomography ( OCT)
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APA ·
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MLA ·
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APA (6th Edition):
Karantalis, V. (2015). Μηχανισμοί εμφράγματος που αποδίδεται σε θρόμβωση ενδοστεφανιαίας ενδοπρόσθεσης (STENT) με τη χρήση της οπτικής συνετικής τομογραφίας. (Thesis). University of Patras; Πανεπιστήμιο Πατρών. Retrieved from http://hdl.handle.net/10442/hedi/36022
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Karantalis, Vasileios. “Μηχανισμοί εμφράγματος που αποδίδεται σε θρόμβωση ενδοστεφανιαίας ενδοπρόσθεσης (STENT) με τη χρήση της οπτικής συνετικής τομογραφίας.” 2015. Thesis, University of Patras; Πανεπιστήμιο Πατρών. Accessed January 23, 2021.
http://hdl.handle.net/10442/hedi/36022.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Karantalis, Vasileios. “Μηχανισμοί εμφράγματος που αποδίδεται σε θρόμβωση ενδοστεφανιαίας ενδοπρόσθεσης (STENT) με τη χρήση της οπτικής συνετικής τομογραφίας.” 2015. Web. 23 Jan 2021.
Vancouver:
Karantalis V. Μηχανισμοί εμφράγματος που αποδίδεται σε θρόμβωση ενδοστεφανιαίας ενδοπρόσθεσης (STENT) με τη χρήση της οπτικής συνετικής τομογραφίας. [Internet] [Thesis]. University of Patras; Πανεπιστήμιο Πατρών; 2015. [cited 2021 Jan 23].
Available from: http://hdl.handle.net/10442/hedi/36022.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Karantalis V. Μηχανισμοί εμφράγματος που αποδίδεται σε θρόμβωση ενδοστεφανιαίας ενδοπρόσθεσης (STENT) με τη χρήση της οπτικής συνετικής τομογραφίας. [Thesis]. University of Patras; Πανεπιστήμιο Πατρών; 2015. Available from: http://hdl.handle.net/10442/hedi/36022
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
◁ [1] [2] [3] [4] [5] … [18] ▶
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Open Access Theses and Dissertations
