subject:(Oncogenic Virus)

1. 濵口, 大輔. Initial viral load in cases of single human papillomavirus 16 or 52 persistent infection is associated with progression of later cytopathological findings in the uterine cervix : ヒトパピローマウィルス16型ないし52型の持続感染における初回ウィルス量は，その後の子宮頸部細胞診の増悪と関連する.

Degree: 博士(医学), 2013, Nagasaki University / 長崎大学

URL: http://hdl.handle.net/10069/35250

► The aim of this study was to investigate the relationship between viral load in single human papillomavirus (HPV) 16 or 52 persistent infection and the… (more)

Subjects/Keywords: cervical cytology; oncogenic human papillomavirus; persistent infection; progression; virus load

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

濵口, �. (2013). Initial viral load in cases of single human papillomavirus 16 or 52 persistent infection is associated with progression of later cytopathological findings in the uterine cervix : ヒトパピローマウィルス16型ないし52型の持続感染における初回ウィルス量は，その後の子宮頸部細胞診の増悪と関連する. (Thesis). Nagasaki University / 長崎大学. Retrieved from http://hdl.handle.net/10069/35250

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

濵口, 大輔. “Initial viral load in cases of single human papillomavirus 16 or 52 persistent infection is associated with progression of later cytopathological findings in the uterine cervix : ヒトパピローマウィルス16型ないし52型の持続感染における初回ウィルス量は，その後の子宮頸部細胞診の増悪と関連する.” 2013. Thesis, Nagasaki University / 長崎大学. Accessed April 22, 2021. http://hdl.handle.net/10069/35250.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

濵口, 大輔. “Initial viral load in cases of single human papillomavirus 16 or 52 persistent infection is associated with progression of later cytopathological findings in the uterine cervix : ヒトパピローマウィルス16型ないし52型の持続感染における初回ウィルス量は，その後の子宮頸部細胞診の増悪と関連する.” 2013. Web. 22 Apr 2021.

Vancouver:

濵口 �. Initial viral load in cases of single human papillomavirus 16 or 52 persistent infection is associated with progression of later cytopathological findings in the uterine cervix : ヒトパピローマウィルス16型ないし52型の持続感染における初回ウィルス量は，その後の子宮頸部細胞診の増悪と関連する. [Internet] [Thesis]. Nagasaki University / 長崎大学; 2013. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/10069/35250.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

濵口 �. Initial viral load in cases of single human papillomavirus 16 or 52 persistent infection is associated with progression of later cytopathological findings in the uterine cervix : ヒトパピローマウィルス16型ないし52型の持続感染における初回ウィルス量は，その後の子宮頸部細胞診の増悪と関連する. [Thesis]. Nagasaki University / 長崎大学; 2013. Available from: http://hdl.handle.net/10069/35250

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Tulane University

2. Strong, Michael J. Transcriptomics in the study of pathogens and human malignancies.

Degree: 2017, Tulane University

URL: https://digitallibrary.tulane.edu/islandora/object/tulane:75236

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Next generation sequencing (NGS) is a relatively new technology that has revolutionized the way scientists discover and investigate pathogens. It has been estimated that a… (more)

Subjects/Keywords: Next generation sequencing; Epstein-Barr virus; Oncogenic pathogens

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APA (6^th Edition):

Strong, M. J. (2017). Transcriptomics in the study of pathogens and human malignancies. (Thesis). Tulane University. Retrieved from https://digitallibrary.tulane.edu/islandora/object/tulane:75236

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Strong, Michael J. “Transcriptomics in the study of pathogens and human malignancies.” 2017. Thesis, Tulane University. Accessed April 22, 2021. https://digitallibrary.tulane.edu/islandora/object/tulane:75236.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Strong, Michael J. “Transcriptomics in the study of pathogens and human malignancies.” 2017. Web. 22 Apr 2021.

Vancouver:

Strong MJ. Transcriptomics in the study of pathogens and human malignancies. [Internet] [Thesis]. Tulane University; 2017. [cited 2021 Apr 22]. Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:75236.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Strong MJ. Transcriptomics in the study of pathogens and human malignancies. [Thesis]. Tulane University; 2017. Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:75236

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Laude, Hélène. Rôle du Polyomavirus de Merkel dans les carcinomes à cellules de Merkel : Merkel Cell Polyomavirus role in Merkel Cell Carcinoma.

Degree: Docteur es, Infectiologie, 2012, Université Paris Descartes – Paris V

URL: http://www.theses.fr/2012PA05T065

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En 2008, le génome d’un nouveau virus a été caractérisé au sein d’un cancer cutané rare survenant préférentiellement chez l’immunodéprimé, le carcinome de Merkel. Ce… (more)

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En 2008, le génome d’un nouveau virus a été caractérisé au sein d’un cancer cutané rare survenant préférentiellement chez l’immunodéprimé, le carcinome de Merkel. Ce nouveau virus appartenait à la famille des Polyomaviridae qui comprend des virus dont le caractère cancérigène chez l’animal est avéré depuis plus de 50 ans. Dénommé Polyomavirus de Merkel puisqu’il semblait lié à la survenue du cancer du même nom, il constituait le premier Polyomavirus impliqué de manière consistante dans un cancer humain. Cette implication reposant sur une étude unique limitée à 10 cas, l’objectif de notre travail de thèse était de confirmer le rôle étiologique du Polyomavirus de Merkel dans le carcinome de Merkel.Nous avons montré que le génome du Polyomavirus de Merkel était présent dans les trois quarts des cas de carcinome de Merkel, mais également que le virus infecte la population générale de manière quasi-ubiquitaire et de nombreux tissus en dehors de la peau. Les faits que chez les sujets atteints de carcinome de Merkel, l’ADN viral soit présent à des taux décelables de manière chronique dans différents tissus et que les titres d’anticorps sériques spécifiques du virus soient élevés suggèrent que ces sujets développent une infection chronique active. Celle-ci pourrait faciliter la survenue de mutations et d’intégrations de l’ADN viral qui sont spécifiquement associées aux carcinomes de Merkel. Ces modifications secondaires du génome viral aboutissent à la production d’oncoprotéines virales par les cellules tumorales, mais à l’abolition des capacités réplicatives donc lytiques du virus et constitueraient ainsi le support de la transformation tumorale.

Nucleotidic sequences defining the genome of a new virus, the Merkel Cell Polyomavirus, has been discovered in 2008 in Merkel cell carcinoma, a rare form of cutaneous cancer developing mostly in immunosupressed individuals. Whereas this new virus belongs to the Polyomaviridae family, which includes known oncogenic viruses in animals, it was the first study consistently implicating a Polyomavirus in human cancer. Because scientific arguments were only based on a ten-case-single report, the primary goal of our work was to confirm the role of the Merkel Cell Polyomavirus in Merkel Cell Carcinoma.Our work demonstrated that Merkel Cell Polyomavirus DNA was indeed present in three quarters of Merkel Cell Carcinoma cases, but also that Merkel Cell Polyomavirus was a near ubiquitous virus infecting various tissues among healthy individuals. Nonetheless, viral DNA is chronically detected in various tissues from Merkel Cell Carcinoma cases, which harbour elevated seric titters of specific antibodies. Those facts suggest that Merkel Cell Polyomavirus develop an active and chronic infection that could favour genomic mutation and integration events specifically associated to Merkel Cell Carcinoma. Those modifications, inducing both expression of truncated viral oncoproteins and abolishment of cell lysis mediated by viral replication, may support cell transformation.

Advisors/Committee Members: Rozenberg, Flore (thesis director).

Subjects/Keywords: Carcinome de Merkel; Polyomavirus de Merkel; Cancer; Virus oncogène; Merkel Cell Carcinoma; Merkel Cell Polyomavirus; Cancer; Oncogenic virus

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APA (6^th Edition):

Laude, H. (2012). Rôle du Polyomavirus de Merkel dans les carcinomes à cellules de Merkel : Merkel Cell Polyomavirus role in Merkel Cell Carcinoma. (Doctoral Dissertation). Université Paris Descartes – Paris V. Retrieved from http://www.theses.fr/2012PA05T065

Chicago Manual of Style (16^th Edition):

Laude, Hélène. “Rôle du Polyomavirus de Merkel dans les carcinomes à cellules de Merkel : Merkel Cell Polyomavirus role in Merkel Cell Carcinoma.” 2012. Doctoral Dissertation, Université Paris Descartes – Paris V. Accessed April 22, 2021. http://www.theses.fr/2012PA05T065.

MLA Handbook (7^th Edition):

Laude, Hélène. “Rôle du Polyomavirus de Merkel dans les carcinomes à cellules de Merkel : Merkel Cell Polyomavirus role in Merkel Cell Carcinoma.” 2012. Web. 22 Apr 2021.

Vancouver:

Laude H. Rôle du Polyomavirus de Merkel dans les carcinomes à cellules de Merkel : Merkel Cell Polyomavirus role in Merkel Cell Carcinoma. [Internet] [Doctoral dissertation]. Université Paris Descartes – Paris V; 2012. [cited 2021 Apr 22]. Available from: http://www.theses.fr/2012PA05T065.

Council of Science Editors:

Laude H. Rôle du Polyomavirus de Merkel dans les carcinomes à cellules de Merkel : Merkel Cell Polyomavirus role in Merkel Cell Carcinoma. [Doctoral Dissertation]. Université Paris Descartes – Paris V; 2012. Available from: http://www.theses.fr/2012PA05T065

4. Kostadinova, Tsvetelina / Костадинова, Цветелина. Seroepidemiological and Laboratory Diagnostic Studies on the Disease and Clinical Importance of Epstein–Barr Virus Infection /// Сероепидемиологични и лабораторно диагностични проучвания върху разпространението и клиничната значимост на Epstein-Barr вирусната инфекция.

Degree: 2017, Medical University of Varna

URL: http://repository.mu-varna.bg/handle/nls/373

► [EN] Despite the assumptions about the role of the virus in human cancers, first evidence comes after the association of Burkitt Lymphoma (BL) with а… (more)

▼ [EN] Despite the assumptions about the role of the virus in human cancers, first evidence comes after the association of Burkitt Lymphoma (BL) with а newly discovered herpes-like virus called the Epstein - Barr virus (EBV). EBV has been acknowledged as the first human oncogenic virus. It was discovered by electron microscopy in 1964 in cell line from child's lymphoma. In the following years, the interest in EBV has been increased. Its medical and social significance is determined by its widespread distribution and association with а number of diseases, including malignancies. Primary infection during adolescence is most often manifested by infectious mononucleosis (IM), whereas in early childhood it is more often asymptomatic or with atypical clinical symptoms. Of great importance for clinical practice is the diagnosis of EBV infection and the possibilities for its improvement. This includes determining the appropriate methods and markers for acute infection and reactivation as well as specific neoplastic diseases, depending on the patient's immune status. Basic diagnosis is а serological immuno-enzyme based (EIA) method for determining virus-specific antibodies. Laboratories in Bulgaria primarily use EBV specific anti-VCA IgM and IgG. The former appear in acute infection, and the latter persist for life and are the main marker for determining seroprevalence in the population. In the patient’s body, however, antibodies are formed and other viral antigens, which, in combination with the above, may give а more accurate interpretation. In addition, the combination of antibodies in different patients may vary making it difficult to detect а primary infection. This requires the introduction of other markers and methods to support the clinical diagnosis. As а representative of the EBV herpesvirus family, persistence in the human body is characterized by а primary infection with the possibility of reactivation, especially in immunocompromised and immunosuppressed patients. At present, these patients are in the focus of the medical community due to the fact that their number increases due to the risk of developing opportunistic infections, reactivation of viral infections, development of lymphomas, etc. Reactivation of EBV is recurrent even in immunocompetent individuals, which is important for its widespread use in the human population, but in immunocompromised patients it can lead to serious life-threatening conditions. Viral reactivation remains а major challenge for laboratory diagnostics. Despite many studies, there are still no uniform criteria for its registration. It is now accepted that polymerase chain reaction (PCR), especially in immunocompromised patients, can provide good information to support clinical diagnosis and therapeutic strategy selection, as well as to indicate the involvement of the virus in the development of oncogenic diseases. EBV has been shown to be involved in the development of lymphoproliferative disorders (PTLD) after haematopoietic stem cell transplantation and organ transplantation.…

Subjects/Keywords: Epstein - Barr virus (EBV); oncogenic; herpesvirus; infection; malignancy; lymphoproliferative disorders; Микробиология и вирусология / Microbiology and Virology

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APA (6^th Edition):

Kostadinova, Tsvetelina / Костадинова, �. (2017). Seroepidemiological and Laboratory Diagnostic Studies on the Disease and Clinical Importance of Epstein–Barr Virus Infection /// Сероепидемиологични и лабораторно диагностични проучвания върху разпространението и клиничната значимост на Epstein-Barr вирусната инфекция. (Thesis). Medical University of Varna. Retrieved from http://repository.mu-varna.bg/handle/nls/373

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kostadinova, Tsvetelina / Костадинова, Цветелина. “Seroepidemiological and Laboratory Diagnostic Studies on the Disease and Clinical Importance of Epstein–Barr Virus Infection /// Сероепидемиологични и лабораторно диагностични проучвания върху разпространението и клиничната значимост на Epstein-Barr вирусната инфекция.” 2017. Thesis, Medical University of Varna. Accessed April 22, 2021. http://repository.mu-varna.bg/handle/nls/373.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kostadinova, Tsvetelina / Костадинова, Цветелина. “Seroepidemiological and Laboratory Diagnostic Studies on the Disease and Clinical Importance of Epstein–Barr Virus Infection /// Сероепидемиологични и лабораторно диагностични проучвания върху разпространението и клиничната значимост на Epstein-Barr вирусната инфекция.” 2017. Web. 22 Apr 2021.

Vancouver:

Kostadinova, Tsvetelina / Костадинова �. Seroepidemiological and Laboratory Diagnostic Studies on the Disease and Clinical Importance of Epstein–Barr Virus Infection /// Сероепидемиологични и лабораторно диагностични проучвания върху разпространението и клиничната значимост на Epstein-Barr вирусната инфекция. [Internet] [Thesis]. Medical University of Varna; 2017. [cited 2021 Apr 22]. Available from: http://repository.mu-varna.bg/handle/nls/373.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kostadinova, Tsvetelina / Костадинова �. Seroepidemiological and Laboratory Diagnostic Studies on the Disease and Clinical Importance of Epstein–Barr Virus Infection /// Сероепидемиологични и лабораторно диагностични проучвания върху разпространението и клиничната значимост на Epstein-Barr вирусната инфекция. [Thesis]. Medical University of Varna; 2017. Available from: http://repository.mu-varna.bg/handle/nls/373

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

5. Yung, Chun-wai. A molecular study of NPC pathogenesis.

Degree: 1994, University of Hong Kong

URL: http://hdl.handle.net/10722/32445

Subjects/Keywords: Oncogenic viruses.; Carcinogenesis.; Epstein-Barr virus.; Nasopharynx - Cancer.

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APA (6^th Edition):

Yung, C. (1994). A molecular study of NPC pathogenesis. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/32445

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yung, Chun-wai. “A molecular study of NPC pathogenesis.” 1994. Thesis, University of Hong Kong. Accessed April 22, 2021. http://hdl.handle.net/10722/32445.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yung, Chun-wai. “A molecular study of NPC pathogenesis.” 1994. Web. 22 Apr 2021.

Vancouver:

Yung C. A molecular study of NPC pathogenesis. [Internet] [Thesis]. University of Hong Kong; 1994. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/10722/32445.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yung C. A molecular study of NPC pathogenesis. [Thesis]. University of Hong Kong; 1994. Available from: http://hdl.handle.net/10722/32445

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

6. Torres, Stella Vidal de Souza, 1967-. Presença de DNA de papilomavírus humano em biópsias de carcinoma espinocelular de pacientes adultos e idosos com câncer de cabeça e pescoço : Presence of human papillomavirus DNA in squamous cell carcinoma biopsies in adults and elderly with head and neck cancer.

Degree: Faculdade de Ciências Médicas; Programa de Pós-Graduação em Gerontologia, 2017, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332850

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Orientadores: Sandra Cecília Botelho Costa, Sandra Helena Alves Bonon

Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas

Made available in DSpace on… (more)

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Orientadores: Sandra Cecília Botelho Costa, Sandra Helena Alves Bonon

Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas

Made available in DSpace on 2018-12-03T12:01:10Z (GMT). No. of bitstreams: 1 Torres_StellaVidalDeSouza_D.pdf: 2869678 bytes, checksum: b78a933dabf66a6ed3055fb5ba7dc160 (MD5) Previous issue date: 2017

Resumo: Mesmo com avançadas modalidades terapêuticas, o carcinoma espinocelular se mostra como responsável pelo aumento da taxa de mortalidade da maioria dos pacientes diagnosticados com neoplasias de cabeça e pescoço. Tumores de cabeça e pescoço associados ao vírus HPV se comportam de modo diferente dos demais. A replicação do HPV ocorre no núcleo das células escamosas e seu ciclo de vida está diretamente relacionado ao programa de diferenciação celular da célula hospedeira. Por outro lado, o câncer causa um estado de imunodepressão, que favorece a ação de agentes infecciosos oportunistas, de modo que reativações virais são comuns em pacientes adultos e idosos. Objetivo: avaliar a prevalência do papilomavírus humano (HPV) em biópsias de tecidos neoplásicos obtidos de pacientes com diagnóstico de neoplasias de cabeça e pescoço. Método: foram selecionados um total de sessenta e oito biópsias de tecidos à fresco e parafinadas. Utilizou-se de técnicas de Biologia Molecular como a Reação em Cadeia da Polimerase tipo nested (n-PCR) para a detecção do DNA viral. A pesquisa foi submetida e aprovada pelo Comitê de Ética em Pesquisa da FCM/Unicamp e o TCLE fornecido e assinado por todos os participantes. Os dados obtidos foram tabulados, organizados e armazenados em planilhas do Programa Office Excel e submetidos à análise estatística. O nível de significância para todas as análises foi de 5%, ou valores de p<0,05. Resultados: treze amostras foram positivas para a presença do DNA de HPV (19,12%), sendo sete casos para as amostras à fresco (35%) e seis para as amostras parafinadas (12,5%). Entre as amostras à fresco (n=20), a maioria dos casos positivos era constituída por homens, brancos e casados com média de idade de 53,3 anos. Quanto à localização, 71,4% dos tumores eram de laringe, classificados como moderadamente diferenciados e se apresentavam no estágio IV de estadiamento, tendo cirurgia, quimio e radioterapia como procedimentos terapêuticos. Todos possuíam história de tabagismo e 85,5% de etilismo. As amostras parafinadas (n=48), apontaram a média de idade de 68,5 anos. A maioria (83,3%) composta por homens, casados (66,6%) e brancos. Em 50% dos casos, a região mais atingida foi a laringe e 83,3% como moderadamente diferenciados. Quanto ao estadiamento, 50% foram classificados no estágio III, apresentando a cirurgia de ressecção do tumor como medida terapêutica mais utilizada. Todos reportaram tabagismo e 66,6% etilismo. A proporção de HPV positivo foi maior entre a população adulta e os achados histopatológicos mostraram a presença de células com coilocitose em ambas as amostras. Conclusão: o DNA do vírus HPV foi mais prevalente em neoplasias de laringe e…

Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS, Bonon, Sandra Helena Alves, Costa, Sandra Cecília Botelho, 1951-, Passeri, Luis Augusto, Lima, Maria Patelli Juliani Souza, Zaratin, Agueda Cleofe Marques, Fattori, André.

Subjects/Keywords: Idosos; Neoplasias de cabeça e pescoço; Vírus oncogênicos; Papillomaviridae; Aged; Head and neck neoplasms; Oncogenic viruses; Papillomaviridae; Tumor virus infections

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Torres, Stella Vidal de Souza, 1. (2017). Presença de DNA de papilomavírus humano em biópsias de carcinoma espinocelular de pacientes adultos e idosos com câncer de cabeça e pescoço : Presence of human papillomavirus DNA in squamous cell carcinoma biopsies in adults and elderly with head and neck cancer. (Doctoral Dissertation). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/332850

Chicago Manual of Style (16^th Edition):

Torres, Stella Vidal de Souza, 1967-. “Presença de DNA de papilomavírus humano em biópsias de carcinoma espinocelular de pacientes adultos e idosos com câncer de cabeça e pescoço : Presence of human papillomavirus DNA in squamous cell carcinoma biopsies in adults and elderly with head and neck cancer.” 2017. Doctoral Dissertation, Universidade Estadual de Campinas. Accessed April 22, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/332850.

MLA Handbook (7^th Edition):

Torres, Stella Vidal de Souza, 1967-. “Presença de DNA de papilomavírus humano em biópsias de carcinoma espinocelular de pacientes adultos e idosos com câncer de cabeça e pescoço : Presence of human papillomavirus DNA in squamous cell carcinoma biopsies in adults and elderly with head and neck cancer.” 2017. Web. 22 Apr 2021.

Vancouver:

Torres, Stella Vidal de Souza 1. Presença de DNA de papilomavírus humano em biópsias de carcinoma espinocelular de pacientes adultos e idosos com câncer de cabeça e pescoço : Presence of human papillomavirus DNA in squamous cell carcinoma biopsies in adults and elderly with head and neck cancer. [Internet] [Doctoral dissertation]. Universidade Estadual de Campinas; 2017. [cited 2021 Apr 22]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332850.

Council of Science Editors:

Torres, Stella Vidal de Souza 1. Presença de DNA de papilomavírus humano em biópsias de carcinoma espinocelular de pacientes adultos e idosos com câncer de cabeça e pescoço : Presence of human papillomavirus DNA in squamous cell carcinoma biopsies in adults and elderly with head and neck cancer. [Doctoral Dissertation]. Universidade Estadual de Campinas; 2017. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332850

Michigan State University

7. Subramaniam, Sugalesini. Understanding the mechanisms of oncogenicity by Marek's disease virus : role of Meq oncoprotein.

Degree: 2013, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:1371

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Thesis Ph. D. Michigan State University. Comparative Medicine and Integrative Biology 2013.

Marek's disease (MD) is one of the most economically significant diseases in chickens.… (more)

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Thesis Ph. D. Michigan State University. Comparative Medicine and Integrative Biology 2013.

Marek's disease (MD) is one of the most economically significant diseases in chickens. It is caused by a highly oncogenic, alpha-herpesvirus named Marek's disease virus (MDV). Currently, the main strategy to control MD is vaccination. However, accumulating evidence points to increase in virulence among MDV field isolates over time, which implicates that new strains of the virus are evolving and could break vaccine protection. This necessitates better understanding of MDV-host interactions, not only to elucidate the events in pathogenesis but also develop strategies for newer and more effective vaccines. One of the major unanswered questions in this area is the mechanism of tumor formation by MDV. The main objective of this project is to gain a comprehensive understanding of host genes that are transcriptionally regulated by Meq, the major oncoprotein of MDV and their relevance in genetic resistance to MD. MDV oncogenicity is largely attributed to the bZIP transcription factor Meq. Although it was discovered in the 1990s, only a few of host target genes have been described. This knowledge gap has impeded our understanding of Meq-induced tumorigenesis. Using a combination of state-of-the-art genomic techniques including ChIP-Seq and microarray analysis, a high confidence list of Meq binding sites and a global transcriptome of genes regulated by Meq was generated. Given the importance of Meq in MDV pathogenesis, we next explored the role of Meq in genetic resistance to MD. Two highly inbred chicken lines, varying in MD resistance, were infected with a virulent strain of MDV, Md5 or a mutant virus lacking Meq, Md-deltaMeq. Analysis of differentially expressed genes provided a list of Meq-dependent genes that are involved in MD resistance and susceptibility. Pathway analysis indicated that MD resistant lines were enriched for positive regulation of cell death whereas the susceptible cell lines were enriched for regulation of cell proliferation. In addition, some of the Meq-regulated pathways like ERK/MAPK signaling and Jak-STAT pathways were also involved in differential MD susceptibility. Taken together, our study provides a comprehensive analysis of how Meq interacts with cellular pathways involved in oncogenesis. In addition, this study forms the basis for selection of candidate genes that might be involved in genetic resistance to Marek's disease.

Description based on online resource; title from PDF t.p. (viewed on Oct. 22, 2013)

Advisors/Committee Members: CHENG, HANS H, BROWN, C TITUS, DODGSON, JERRY, SCHWARTZ, RICHARD.

Subjects/Keywords: Marek's disease; Oncogenic viruses – Mechanism of action; Chickens – Virus diseases – Research; Veterinary virology; Genetics; Veterinary medicine; Meq oncoprotein

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APA (6^th Edition):

Subramaniam, S. (2013). Understanding the mechanisms of oncogenicity by Marek's disease virus : role of Meq oncoprotein. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:1371

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Subramaniam, Sugalesini. “Understanding the mechanisms of oncogenicity by Marek's disease virus : role of Meq oncoprotein.” 2013. Thesis, Michigan State University. Accessed April 22, 2021. http://etd.lib.msu.edu/islandora/object/etd:1371.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Subramaniam, Sugalesini. “Understanding the mechanisms of oncogenicity by Marek's disease virus : role of Meq oncoprotein.” 2013. Web. 22 Apr 2021.

Vancouver:

Subramaniam S. Understanding the mechanisms of oncogenicity by Marek's disease virus : role of Meq oncoprotein. [Internet] [Thesis]. Michigan State University; 2013. [cited 2021 Apr 22]. Available from: http://etd.lib.msu.edu/islandora/object/etd:1371.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Subramaniam S. Understanding the mechanisms of oncogenicity by Marek's disease virus : role of Meq oncoprotein. [Thesis]. Michigan State University; 2013. Available from: http://etd.lib.msu.edu/islandora/object/etd:1371

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

8. Raines, Maribeth Anne. C-erb B activation and avian leukosis virus induced erythroblastosis.

Degree: PhD, Department of Biochemistry, 1987, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:19733

Subjects/Keywords: Avian leukosis; Poultry – Virus diseases; Hematopoietic system – Cancer; Oncogenic viruses

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APA (6^th Edition):

Raines, M. A. (1987). C-erb B activation and avian leukosis virus induced erythroblastosis. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:19733

Chicago Manual of Style (16^th Edition):

Raines, Maribeth Anne. “C-erb B activation and avian leukosis virus induced erythroblastosis.” 1987. Doctoral Dissertation, Michigan State University. Accessed April 22, 2021. http://etd.lib.msu.edu/islandora/object/etd:19733.

MLA Handbook (7^th Edition):

Raines, Maribeth Anne. “C-erb B activation and avian leukosis virus induced erythroblastosis.” 1987. Web. 22 Apr 2021.

Vancouver:

Raines MA. C-erb B activation and avian leukosis virus induced erythroblastosis. [Internet] [Doctoral dissertation]. Michigan State University; 1987. [cited 2021 Apr 22]. Available from: http://etd.lib.msu.edu/islandora/object/etd:19733.

Council of Science Editors:

Raines MA. C-erb B activation and avian leukosis virus induced erythroblastosis. [Doctoral Dissertation]. Michigan State University; 1987. Available from: http://etd.lib.msu.edu/islandora/object/etd:19733

Loma Linda University

9. Wongworawat, Yan Chen. Factors Promoting Human Papillomavirus Mediated Cervical Carcinogenesis.

Degree: PhD, Basic Sciences, 2016, Loma Linda University

URL: https://scholarsrepository.llu.edu/etd/338

► High-risk human papillomavirus (HPV) is the causative agent of cervical cancer. Integration of the HPV genome into the host genome is a key event… (more)

Subjects/Keywords: Biochemistry; Uterine Cervical Neoplasms; Oncogenic Viruses; Papillomavirus; Human; Carcinoma; Squamous Cell; Oncogene Proteins; Viral; Human Papillomavirus; Cervical cancer; Carcinogenesis; Viral integration; Virus-mediated factors; Cancer susceptibility

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APA (6^th Edition):

Wongworawat, Y. C. (2016). Factors Promoting Human Papillomavirus Mediated Cervical Carcinogenesis. (Doctoral Dissertation). Loma Linda University. Retrieved from https://scholarsrepository.llu.edu/etd/338

Chicago Manual of Style (16^th Edition):

Wongworawat, Yan Chen. “Factors Promoting Human Papillomavirus Mediated Cervical Carcinogenesis.” 2016. Doctoral Dissertation, Loma Linda University. Accessed April 22, 2021. https://scholarsrepository.llu.edu/etd/338.

MLA Handbook (7^th Edition):

Wongworawat, Yan Chen. “Factors Promoting Human Papillomavirus Mediated Cervical Carcinogenesis.” 2016. Web. 22 Apr 2021.

Vancouver:

Wongworawat YC. Factors Promoting Human Papillomavirus Mediated Cervical Carcinogenesis. [Internet] [Doctoral dissertation]. Loma Linda University; 2016. [cited 2021 Apr 22]. Available from: https://scholarsrepository.llu.edu/etd/338.

Council of Science Editors:

Wongworawat YC. Factors Promoting Human Papillomavirus Mediated Cervical Carcinogenesis. [Doctoral Dissertation]. Loma Linda University; 2016. Available from: https://scholarsrepository.llu.edu/etd/338

Loma Linda University

10. Evans, Whitney S. Anti-tumor Mechanisms of HPV16 E6*.

Degree: PhD, Basic Sciences, 2016, Loma Linda University

URL: https://scholarsrepository.llu.edu/etd/374

► High-risk types of the human papillomavirus (HR-HPV) are the causative agents of nearly all cases of cervical cancer, as well as a significant number… (more)

▼ High-risk types of the human papillomavirus (HR-HPV) are the causative agents of nearly all cases of cervical cancer, as well as a significant number of head, neck, penile, vulvar and anal cancers. Like many other viruses with small genomes, HPV (~8 kb) utilizes numerous mechanisms to increase the capacity of its genome to encode the proteins necessary for successful completion of its infectious life cycle, including alternative splicing. Studies over the past few decades have focused intensively on the activities and roles of E6 proteins from HR-HPVs during the process of cellular transformation, clearly implicating E6 as a major transforming agent. In contrast, the role of the smaller splice isoform, E6*, in the carcinogenic process has not yet been established. Based on previous studies, we proposed that E6* had the potential to reduce tumor formation in vivo. To test this prediction, we injected HPV16+ SiHa and HPV16- C33A cervical cancer cells overexpressing E6* into nude mice and monitored tumor growth over several weeks while comparing them with control tumors lacking E6* overexpression. E6* was found to reduce growth in both SiHa- and C33A-derived tumors. These findings were followed up by in vitro experiments showing that E6* binds to full-length E6 and decreases the growth rate in SiHa cells. Subsequently, we sought to find the cellular pathways most influenced by E6* in attenuating SiHa and C33A tumor growth. Thus, proteomic analysis was performed on both cell lines, revealing that the β -Integrin pathway in SiHa cells and the mitochondrial dysfunction and oxidative phosphorylation pathway in C33A cells were the most significantly altered. Proteomic data was confirmed using immunoblot, microscopy, and flow cytometry techniques. These findings will assist in our quest for understanding the fundamental driving forces behind HPV-mediated and non-HPV-mediated cervical cancers and introduce novel ideas for small molecule inhibitors. Our studies provide several promising leads for future analyses, specifically in the context of human cancers, and carry with them the exciting possibility of replicating the anti-oncogenic activity of E6* in such a way as to provide therapeutic benefit. Advisors/Committee Members: Duerksen-Hughes, Penelope J., Brantley, Eileen, Drake, Wonder P., Filippov, Valeri, Reeves, Mark E., Zhang, Lubo.

Subjects/Keywords: Medical Pharmacology; Medical Sciences; Medicine and Health Sciences; Papillomavirus - Human - Pathogenicity; Uterine Cervical Neoplasms;

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APA (6^th Edition):

Evans, W. S. (2016). Anti-tumor Mechanisms of HPV16 E6*. (Doctoral Dissertation). Loma Linda University. Retrieved from https://scholarsrepository.llu.edu/etd/374

Chicago Manual of Style (16^th Edition):

Evans, Whitney S. “Anti-tumor Mechanisms of HPV16 E6*.” 2016. Doctoral Dissertation, Loma Linda University. Accessed April 22, 2021. https://scholarsrepository.llu.edu/etd/374.

MLA Handbook (7^th Edition):

Evans, Whitney S. “Anti-tumor Mechanisms of HPV16 E6*.” 2016. Web. 22 Apr 2021.

Vancouver:

Evans WS. Anti-tumor Mechanisms of HPV16 E6*. [Internet] [Doctoral dissertation]. Loma Linda University; 2016. [cited 2021 Apr 22]. Available from: https://scholarsrepository.llu.edu/etd/374.

Council of Science Editors:

Evans WS. Anti-tumor Mechanisms of HPV16 E6*. [Doctoral Dissertation]. Loma Linda University; 2016. Available from: https://scholarsrepository.llu.edu/etd/374

11. Ruta, Martin. Identification and characterization of proteins encoded by acute murine erythroleukemia viruses.

Degree: PhD, 1981, Oregon Health Sciences University

URL: doi:10.6083/M43F4MSH ; http://digitalcommons.ohsu.edu/etd/2236

Subjects/Keywords: Cell Membrane; Leukemia, Erythroblastic, Acute; Friend murine leukemia virus; Glycoproteins; Leukemia – etiology; Oncogenic Viruses; Rauscher Virus; Retroviridae; Tumor Virus Infections; Virus Replication

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APA (6^th Edition):

Ruta, M. (1981). Identification and characterization of proteins encoded by acute murine erythroleukemia viruses. (Doctoral Dissertation). Oregon Health Sciences University. Retrieved from doi:10.6083/M43F4MSH ; http://digitalcommons.ohsu.edu/etd/2236

Chicago Manual of Style (16^th Edition):

Ruta, Martin. “Identification and characterization of proteins encoded by acute murine erythroleukemia viruses.” 1981. Doctoral Dissertation, Oregon Health Sciences University. Accessed April 22, 2021. doi:10.6083/M43F4MSH ; http://digitalcommons.ohsu.edu/etd/2236.

MLA Handbook (7^th Edition):

Ruta, Martin. “Identification and characterization of proteins encoded by acute murine erythroleukemia viruses.” 1981. Web. 22 Apr 2021.

Vancouver:

Ruta M. Identification and characterization of proteins encoded by acute murine erythroleukemia viruses. [Internet] [Doctoral dissertation]. Oregon Health Sciences University; 1981. [cited 2021 Apr 22]. Available from: doi:10.6083/M43F4MSH ; http://digitalcommons.ohsu.edu/etd/2236.

Council of Science Editors:

Ruta M. Identification and characterization of proteins encoded by acute murine erythroleukemia viruses. [Doctoral Dissertation]. Oregon Health Sciences University; 1981. Available from: doi:10.6083/M43F4MSH ; http://digitalcommons.ohsu.edu/etd/2236

12. Orlando, Paul A. The Evolutionary ecology of physiological constraints in ecological communities and HPV-induced cancer.

Degree: 2012, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/9573

► I use consumer resource theory and evolutionary game theory in developing theory with regards to physiology, protists, and viruses. I use differential equation consumer resource… (more)

▼ I use consumer resource theory and evolutionary game theory in developing theory with regards to physiology, protists, and viruses. I use differential equation consumer resource systems to provide an ecological basis for theoretical exploration. And I use game theory to model natural selection within an ecological context. I investigate the effects of stoichiometric constraints on consumers in a graphical framework. I found that when stoichiometry is integrated into consumer resource models, ecological communities take on a more complex array of possible states. When resource equilibrium abundances are low, ecological communities are nearly identical to those used to characterize animal communities based on substitutable resources. However, when resource equilibrium abundances are high, ecological communities are similar to those used to characterize plant communities based on essential resources. I investigate the effects of species that can switch trophic levels by a morphologic transformation on ecological communities. I found that these species often stabilize population dynamics, which favors each morph as a separate species. I conclude that switching species likely evolve in environments with stochastic resource fluctuations or extrinsic drivers of resource levels. I also found that although switching species can fill diverse ecological niches in a community, they do not necessarily restrict diversity. I investigate the role of digestive physiology coupled with the digestive properties of resources in structuring ecological communities. I found that bulky resources select for large guts with long throughput times, and high energy/volume resources select for small guts and short throughput times. Most resource pairs lead to the evolution of a specialist on the richer resource followed by the invasion and evolution of a generalist. I also applied theory to HPV induced cancers. I hypothesized that HPV faces a life history tradeoff, where HR HPV is persistent but not very infectious, and vice versa for low-risk HPV. We found that different sexual subcultures within the human population could explain the origin and maintenance of these distinct HPV types. Furthermore, I made a PDE model of HPV infection within mucosal tissue to discover the links between cell population dynamics and HPV protein expression. And how somatic evolution of cells produces tissue level changes. I found that HPV’s proteins likely increase the density of tissue at which cells can divide and possibly also slow the migration rate of cells to the skin surface. I also found that somatic evolution is an alternative explanation for tissue level changes observed during high-risk HPV infection. Advisors/Committee Members: Brown, Joel S. (advisor), Mitchell, William A. (committee member), Grande, Terry (committee member), Buhse, Howard E. (committee member), Whelan, Christopher J. (committee member), Nyberg, Dennis W. (committee member), Gatenby, Robert A. (committee member).

Subjects/Keywords: Evolutionary game theory; Consumer-reosurce model; Community structure; Ecological stoichiometry; Polymorphic species; Human Papillomavirus; Oncogenic Virus

10 more images…

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APA (6^th Edition):

Orlando, P. A. (2012). The Evolutionary ecology of physiological constraints in ecological communities and HPV-induced cancer. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/9573

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Orlando, Paul A. “The Evolutionary ecology of physiological constraints in ecological communities and HPV-induced cancer.” 2012. Thesis, University of Illinois – Chicago. Accessed April 22, 2021. http://hdl.handle.net/10027/9573.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Orlando, Paul A. “The Evolutionary ecology of physiological constraints in ecological communities and HPV-induced cancer.” 2012. Web. 22 Apr 2021.

Vancouver:

Orlando PA. The Evolutionary ecology of physiological constraints in ecological communities and HPV-induced cancer. [Internet] [Thesis]. University of Illinois – Chicago; 2012. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/10027/9573.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Orlando PA. The Evolutionary ecology of physiological constraints in ecological communities and HPV-induced cancer. [Thesis]. University of Illinois – Chicago; 2012. Available from: http://hdl.handle.net/10027/9573

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. Pedergnana, Vincent. Contrôle génétique de la réponse à l’infection par des virus oncogènes en population endémique : Pas de titre traduit.

Degree: Docteur es, Génétique statistique, 2013, Université Paris Descartes – Paris V

URL: http://www.theses.fr/2013PA05S022

►

La recherche de facteurs génétiques de susceptibilité aux infections virale dans des populations générales exhaustives endémiques est une approche originale en épidémiologie génétique. Nos travaux… (more)

▼

La recherche de facteurs génétiques de susceptibilité aux infections virale dans des populations générales exhaustives endémiques est une approche originale en épidémiologie génétique. Nos travaux de thèse nous ont permis d’établir, dans une population endémique pour deux virus oncogènes MCPyV et HHV-8 au Cameroun et dans une population endémique pour le VHC en Egypte, plusieurs arguments forts en faveur d’une susceptibilité génétique aux infections par les virus oncogènes humains définies par la séropositivité/ séronégativité vis-à-vis du virus impliqué. Concernant l’infection par le MCPyV, dont les modes de transmission sont peu connus, nous avons mis en évidence l’existence de fortes corrélations familiales mère-enfant et entre enfants pour la séropositivité au virus, en faveur d’une transmission virale par contacts proches. Ces résultats sont similaires à ceux observés pour l’HHV-8, dans la même population, virus pour lequel la transmission par voie salivaire est l’hypothèse la plus forte. Concernant l’infection par l’HHV-8, nous avons identifié un locus majeur de prédisposition à l’infection par une analyse de ségrégation mettant un gène majeur mendélien autosomique récessif prédisposant à l’infection, suivie d’une analyse de liaison paramétrique utilisant le modèle de l’analyse de ségrégation. Concernant l’infection par le VHC, nous avons identifié par une analyse de liaison génétique un locus majeur de prédisposition à l’infection. Nous avons ensuite identifié, par une analyse d’association en génome entier sur une grande cohorte de plus de 6500 individus, trois signaux associés avec l’infection par le VHC. Par ailleurs, nous avons également réalisé une étude fine des variants du locus du gène IL28B, associés à la clairance du VHC, cohérente avec les résultats publiés au cours de nos travaux. L’identification de facteurs génétiques impliqués dans la susceptibilité aux infections virales oncogènes et aux cancers associés permettra de mieux comprendre la physiopathologie de la réponse à ces infections et les mécanismes intervenant depuis l’exposition virale jusqu’au développement de cancers.

The identification of genetic variants predisposing to viral infection in highly endemic general populations is an original approach in genetic epidemiology. Our work suggests a genetic control of the susceptibility to human oncogenic viruses infection, in a population in Cameroon in which MCPyV and HHV-8 are highly endemic and in an Egyptian population in which HCV is endemic. MCPyV is thought to be the etiological agent of Merkel cell carcinoma, but little is known about its distribution and modes of transmission. We provided evidence for familial aggregation of MCPyV infection status suggesting that MCPyV infection is acquired through close contact, possibly involving saliva and/or the skin, especially between young siblings and between mothers and their children. Infection with HHV-8 has been shown to display strong familial aggregation, in countries in which HHV-8 infection is endemic. Our segregation analysis…

Advisors/Committee Members: Abel, Laurent (thesis director).

Subjects/Keywords: Epidémiologie génétique; Génétique humaine; Contrôle de l’infection; MCPyV; HHV-8; VHC; Virus oncogènes; Transmission familiale; Analyse de ségrégation; Analyse de liaison génétique; Analyse d’association; Genetic epidemiology; Human genetic; Control of infection; MCPyV; HHV-8; HCV; Oncogenic viruses; Familial transmission; Segregation analysis; Linkgae analyse; Association analysis; 616.042

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APA (6^th Edition):

Pedergnana, V. (2013). Contrôle génétique de la réponse à l’infection par des virus oncogènes en population endémique : Pas de titre traduit. (Doctoral Dissertation). Université Paris Descartes – Paris V. Retrieved from http://www.theses.fr/2013PA05S022

Chicago Manual of Style (16^th Edition):

Pedergnana, Vincent. “Contrôle génétique de la réponse à l’infection par des virus oncogènes en population endémique : Pas de titre traduit.” 2013. Doctoral Dissertation, Université Paris Descartes – Paris V. Accessed April 22, 2021. http://www.theses.fr/2013PA05S022.

MLA Handbook (7^th Edition):

Pedergnana, Vincent. “Contrôle génétique de la réponse à l’infection par des virus oncogènes en population endémique : Pas de titre traduit.” 2013. Web. 22 Apr 2021.

Vancouver:

Pedergnana V. Contrôle génétique de la réponse à l’infection par des virus oncogènes en population endémique : Pas de titre traduit. [Internet] [Doctoral dissertation]. Université Paris Descartes – Paris V; 2013. [cited 2021 Apr 22]. Available from: http://www.theses.fr/2013PA05S022.

Council of Science Editors:

Pedergnana V. Contrôle génétique de la réponse à l’infection par des virus oncogènes en population endémique : Pas de titre traduit. [Doctoral Dissertation]. Université Paris Descartes – Paris V; 2013. Available from: http://www.theses.fr/2013PA05S022

14. McGraw, Thomas L. (Thomas Lee). The Effect of N, N Bis (ethylene)-P (1-adamantyl) Phosphonic Diamide on Rous Sarcoma Virus.

Degree: 1988, North Texas State University

URL: https://digital.library.unt.edu/ark:/67531/metadc501033/

► The drug, N,N bis (ethylene)-P (1-adamantyl) phosphonic diamide inhibits focus formation of Rous Sarcoma Virus in tissue culture. Transformation of chick cells was inhibited when… (more)

Subjects/Keywords: Rous Sarcoma Virus; antiviral agents; viral growth; Rous sarcoma.; Oncogenic viruses.; Antiviral agents.; Phosphonic acids.

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APA (6^th Edition):

McGraw, T. L. (. L. (1988). The Effect of N, N Bis (ethylene)-P (1-adamantyl) Phosphonic Diamide on Rous Sarcoma Virus. (Thesis). North Texas State University. Retrieved from https://digital.library.unt.edu/ark:/67531/metadc501033/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McGraw, Thomas L (Thomas Lee). “The Effect of N, N Bis (ethylene)-P (1-adamantyl) Phosphonic Diamide on Rous Sarcoma Virus.” 1988. Thesis, North Texas State University. Accessed April 22, 2021. https://digital.library.unt.edu/ark:/67531/metadc501033/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McGraw, Thomas L (Thomas Lee). “The Effect of N, N Bis (ethylene)-P (1-adamantyl) Phosphonic Diamide on Rous Sarcoma Virus.” 1988. Web. 22 Apr 2021.

Vancouver:

McGraw TL(L. The Effect of N, N Bis (ethylene)-P (1-adamantyl) Phosphonic Diamide on Rous Sarcoma Virus. [Internet] [Thesis]. North Texas State University; 1988. [cited 2021 Apr 22]. Available from: https://digital.library.unt.edu/ark:/67531/metadc501033/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McGraw TL(L. The Effect of N, N Bis (ethylene)-P (1-adamantyl) Phosphonic Diamide on Rous Sarcoma Virus. [Thesis]. North Texas State University; 1988. Available from: https://digital.library.unt.edu/ark:/67531/metadc501033/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Dunton, Helen. Immunocompetence in the AKR Mouse.

Degree: 1976, North Texas State University

URL: https://digital.library.unt.edu/ark:/67531/metadc504367/

► A model for the study of the relationship of immunity to cancer is found in AKR mice which harbor Gross virus. This genetically transmitted virus… (more)

Subjects/Keywords: immune responses; Immunocompetent cells.; Oncogenic viruses.; Cancer – Immunological aspects.; Mouse leukemia complex.; Gross virus; AKR mice

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APA (6^th Edition):

Dunton, H. (1976). Immunocompetence in the AKR Mouse. (Thesis). North Texas State University. Retrieved from https://digital.library.unt.edu/ark:/67531/metadc504367/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dunton, Helen. “Immunocompetence in the AKR Mouse.” 1976. Thesis, North Texas State University. Accessed April 22, 2021. https://digital.library.unt.edu/ark:/67531/metadc504367/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dunton, Helen. “Immunocompetence in the AKR Mouse.” 1976. Web. 22 Apr 2021.

Vancouver:

Dunton H. Immunocompetence in the AKR Mouse. [Internet] [Thesis]. North Texas State University; 1976. [cited 2021 Apr 22]. Available from: https://digital.library.unt.edu/ark:/67531/metadc504367/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dunton H. Immunocompetence in the AKR Mouse. [Thesis]. North Texas State University; 1976. Available from: https://digital.library.unt.edu/ark:/67531/metadc504367/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

16. Francisco Octávio Teixeira Pacca. \"Estudo da prevalência do papilomavirus humano e dos aspectos clínicos e histológicos na queilite actínica crônica\".

Degree: 2007, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/23/23139/tde-07052007-173313/

►

Os papilomavírus humanos (HPVs) oncogênicos são importantes agentes na etiologia do câncer ginecológico e atualmente tem sido relacionados também a algumas lesões cancerizáveis e a… (more)

▼

Os papilomavírus humanos (HPVs) oncogênicos são importantes agentes na etiologia do câncer ginecológico e atualmente tem sido relacionados também a algumas lesões cancerizáveis e a alguns tipos de cânceres de boca. Com o objetivo de avaliar a relação entre os HPVs e um tipo de lesão cancerizável de boca que acomete os lábios chamada queilite actínica crônica (QAC), foram avaliados e considerados aptos para a pesquisa 29 pacientes portadores de QAC. A reação em cadeia pela polimerase (PCR) foi utilizada para detectar a presença do HPV em amostras de tecido fresco, provenientes de lábios doentes onde todos os casos apresentaram resultados negativos. A QAC ocorreu em 100% nos indivíduos da raça branca, em 19 homens e 10 mulheres e na idade média de 56,14 anos. Foram avaliados também os aspectos clínicos e histológicos da QAC sendo encontrados 14 casos de atipia epitelial discreta (48,27%), 10 casos de atipia epitelial moderada (34,49%) e 5 casos de atipia epitelial severa (17,24%). Através de análise estatística concluímos que clinicamente a presença de áreas leucoplásicas e o tempo de evolução da lesão superior a 5 anos estão diretamente relacionados aos casos de atipias epiteliais mais graves. O hábito de fumar e de beber parecem contribuir, mas não obtiveram resultados estatisticamente significativos ao aparecimento da QAC.

The oncogenic human papillomaviruses (HPVs) are important agents in the etiology of gynecological cancer and have been recently related to some premalignant lesions and to some types of mouth cancer. In order to evaluate the relation between HPVs and one type of precancerous lesion that affects the lips called chronic actinic cheilitis (CAC), 29 CAC patients were assessed and considered eligible for the study. The polymerase chain reaction (PCR) was used to detect the presence of HPV in fresh tissue samples of affected lips. All results were negative. All CAC patients were Caucasian, 19 males and 10 women, mean age of 56.14 years. The clinical and histological aspects of CAC were also assessed - there were 14 cases of discreet (48.27%), 10 cases of moderate (34.49%) and 5 cases of severe epithelial atypia (17.24%). By statistical analysis we concluded that, clinically, the presence of leukoplastic areas and progression of the lesion for over five years are directly related to more severe epithelial atypia. Smoking and drinking habits seem to contribute to the condition but achieved no statistical significance regarding onset of CAC.

Advisors/Committee Members: Gilberto Marcucci, Paulo José Bordini, Artur Cerri, Jayro Guimaraes Junior, Suzie Aparecida de Lacerda.

Subjects/Keywords: Papiloma; Queilite; Reação em cadeia da polimerase; Vírus oncogênicos; Cheilitis; Oncogenic virus; Papilloma; Polymerase chain reaction

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APA (6^th Edition):

Pacca, F. O. T. (2007). \"Estudo da prevalência do papilomavirus humano e dos aspectos clínicos e histológicos na queilite actínica crônica\". (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/23/23139/tde-07052007-173313/

Chicago Manual of Style (16^th Edition):

Pacca, Francisco Octávio Teixeira. “\"Estudo da prevalência do papilomavirus humano e dos aspectos clínicos e histológicos na queilite actínica crônica\".” 2007. Doctoral Dissertation, University of São Paulo. Accessed April 22, 2021. http://www.teses.usp.br/teses/disponiveis/23/23139/tde-07052007-173313/.

MLA Handbook (7^th Edition):

Pacca, Francisco Octávio Teixeira. “\"Estudo da prevalência do papilomavirus humano e dos aspectos clínicos e histológicos na queilite actínica crônica\".” 2007. Web. 22 Apr 2021.

Vancouver:

Pacca FOT. \"Estudo da prevalência do papilomavirus humano e dos aspectos clínicos e histológicos na queilite actínica crônica\". [Internet] [Doctoral dissertation]. University of São Paulo; 2007. [cited 2021 Apr 22]. Available from: http://www.teses.usp.br/teses/disponiveis/23/23139/tde-07052007-173313/.

Council of Science Editors:

Pacca FOT. \"Estudo da prevalência do papilomavirus humano e dos aspectos clínicos e histológicos na queilite actínica crônica\". [Doctoral Dissertation]. University of São Paulo; 2007. Available from: http://www.teses.usp.br/teses/disponiveis/23/23139/tde-07052007-173313/

17. Rafael Ciro Marques Cavalcante. Desenvolvimento de estratégias vacinais contra tumores induzidos pelo vírus do papiloma humano tipo 16 (HPV-16) baseadas em linhagens geneticamente modificadas de Bacillus subtilis.

Degree: 2008, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/42/42132/tde-27112008-134649/

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Bacillus subtilis é uma bactéria gram-positiva, não patogênica, formadora de esporos e com um grande conhecimento disponível a cerca de sua genética e fisiologia, comparável… (more)

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Bacillus subtilis é uma bactéria gram-positiva, não patogênica, formadora de esporos e com um grande conhecimento disponível a cerca de sua genética e fisiologia, comparável apenas à Escherichia coli K12. Recentemente, linhagens geneticamente modificadas de B. subtilis foram utilizadas como veículos vacinais mas, até o momento, não se havia avaliado a indução de respostas imunológicas citotóxicas (linfócitos T CD8+) específicas em camundongos imunizados com esporos ou células vegetativas. No presente trabalho, avaliouse a indução de linfócitos T CD8+ em animais imunizados com linhagens vacinais de B. subtilis. Inicialmente empregou-se como alvo a proteína E7 de vírus papiloma humano tipo 16 (HPV-16) fusionada ou não à proteína gD do vírus herpes simples tipo 1 (HSV-1). Em uma segunda estratégia, empregou-se como alvo a subunidade B da toxina termolábil (LTB) de E. coli enterotoxicogênica (ETEC) co-expressa ou fusionada à proteína GroEL2 de Mycobacterium bovis. As quantidades de E7 e gDE7 expressas pelas linhagens recombinantes de B.subtilis ficaram abaixo do limite de detecção e não foram suficientes para ativação de células T CD8+ específicas. Por outro lado, linhagens de B. subtilis capazes de expressar LTB e GroEL2 promoveram a ativação de linfócitos T CD8+ específicos. De um modo geral, o presente trabalho representa uma contribuição inédita sobre a ativação de respostas imunológicas de base celular em camundongos imunizados com linhagens recombinantes de B. subtilis e os resultados obtidos certamente contribuirão para a geração de veículos vacinais mais efetivos na profilaxia e tratamento de diferentes doenças infecciosas, como infecções virais, ou degenerativas, como o câncer.

Bacillus subtilis is a sporulated, non pathogenic, gram-positive bacterial species with a large amount of information concering its genetics and physiology, comparable only to Escherichia coli K12. Recently, genetically modified B.subtilis strains were successfully employed as vaccine vehicles but there is no information concerning the activation of antigen specific cytotoxic immune responses (T CD8+ lymphocytes) in mice vaccinated with either vegetative cells or spores. In the present report, we evaluated the activation of CD8+ T cell responses in mice immunized with B. subtilis vaccine strains genetically modified in order to express the human papillomavirus type 16 (HPV-16) E7 protein as a target antigen, isolated or genetically fused to the type I herpes simplex vírus (HSV-1) gD protein. In a second approach, we have also tested the B subunit heat labile toxin, produced by enterotoxigenic E. coli (ETEC) strains, coexpressed or genetically fused to the Mycobacterium bovis GroEL2 protein. E7 and gDE7 expression by B.subtilis vaccine strains were bellow the detection limits and did not allow the activation of antigen-specific CD8+ T cell responses in vaccinated mice. On the other hand, LTB-specific CD8+ T cell responses were detected in mice immunized with B. subtilis expressing both LTB and GroEL2. Collectively, the present…

Advisors/Committee Members: Luis Carlos de Souza Ferreira, Paulo Lee Ho, Beny Spira.

Subjects/Keywords: Bacillus gram-positivos; Linfócitos T; Vacinas; Vírus oncogênicos; Gram-positive bacillus; Oncogenic virus; T lymphocytes; Vaccines

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cavalcante, R. C. M. (2008). Desenvolvimento de estratégias vacinais contra tumores induzidos pelo vírus do papiloma humano tipo 16 (HPV-16) baseadas em linhagens geneticamente modificadas de Bacillus subtilis. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/42/42132/tde-27112008-134649/

Chicago Manual of Style (16^th Edition):

Cavalcante, Rafael Ciro Marques. “Desenvolvimento de estratégias vacinais contra tumores induzidos pelo vírus do papiloma humano tipo 16 (HPV-16) baseadas em linhagens geneticamente modificadas de Bacillus subtilis.” 2008. Masters Thesis, University of São Paulo. Accessed April 22, 2021. http://www.teses.usp.br/teses/disponiveis/42/42132/tde-27112008-134649/.

MLA Handbook (7^th Edition):

Cavalcante, Rafael Ciro Marques. “Desenvolvimento de estratégias vacinais contra tumores induzidos pelo vírus do papiloma humano tipo 16 (HPV-16) baseadas em linhagens geneticamente modificadas de Bacillus subtilis.” 2008. Web. 22 Apr 2021.

Vancouver:

Cavalcante RCM. Desenvolvimento de estratégias vacinais contra tumores induzidos pelo vírus do papiloma humano tipo 16 (HPV-16) baseadas em linhagens geneticamente modificadas de Bacillus subtilis. [Internet] [Masters thesis]. University of São Paulo; 2008. [cited 2021 Apr 22]. Available from: http://www.teses.usp.br/teses/disponiveis/42/42132/tde-27112008-134649/.

Council of Science Editors:

Cavalcante RCM. Desenvolvimento de estratégias vacinais contra tumores induzidos pelo vírus do papiloma humano tipo 16 (HPV-16) baseadas em linhagens geneticamente modificadas de Bacillus subtilis. [Masters Thesis]. University of São Paulo; 2008. Available from: http://www.teses.usp.br/teses/disponiveis/42/42132/tde-27112008-134649/

18. Juliana Nogueira Martins Rodrigues. Caracterização molecular do Epstein-Barr vírus (EBV) em pacientes portadores de HIV, em tratamento, atendidos no sistema hospitalar do sistema penitenciário do Estado de São Paulo.

Degree: 2008, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/42/42132/tde-27032009-154240/

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O Epstein-Barr vírus (EBV) é a única espécie humana pertencente ao gênero Lymphocryptovirus. A transmissão ocorre através da saliva contaminada e geralmente ainda na infância.… (more)

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O Epstein-Barr vírus (EBV) é a única espécie humana pertencente ao gênero Lymphocryptovirus. A transmissão ocorre através da saliva contaminada e geralmente ainda na infância. Nosso estudo analisou 165 amostras clínicas de pacientes, portadores de HIV, em tratamento com antiretrovirais, atendidos no Sistema Hospitalar do Sistema Penitenciário do Estado de São Paulo. Nosso enfoque foi pesquisar o EBV nas células mononucleares do sangue periférico, através das técnicas de PCR, Nested-PCR e seqüenciamento de nucleotídeos. Os resultados obtidos, indicaram que 11,51% (19) das amostras analisadas, apresentaram-se positivas para o EBV. Essas 19 amostras, foram seqüenciadas com primers específicos para a região da EBNA-1 (Epstein Barr Nuclear Antigen 1). As amostras foram alinhadas com o auxílio do DNASTAR. Ao alinharmos as amostras, encontramos uma troca de base (de G para A) em 7 amostras e essa troca não alterou a conformação da proteína EBNA-1. Na análise filogenética de nossas sequências com as depositadas no GenBank, foi possível observar dois grupos, que representam tipo 1 e o tipo 2 do EBV. 100% das amostras estudadas por nós foram identificadas como pertencentes ao grupo que caracteriza o tipo 2. Sendo assim, as 7 amostras que apresentaram a troca sugerem a origem um novo subtipo.

The Epstein-Barr Virus (EBV) is the only species to the genus Lymphocriptovirus that infects humans. One of the possible route for its transmission thought by contamined saliva and usually occurs in the childhood. This study analysed 165 clinical samples from HIV infected patients, treated by HARRT, attended in the Hospitalar System in the Penitentiary System from Sao Paulo State. The aim of this study was to search EBV in peripheral blood mononuclear cells by PCR, Nested-PCR and sequencing analysis. The results showed 11,51% of the analysed samples, positive for EBV. This samples, was sequenced with specifics primers from the EBNA-1 (Epstein Barr Nuclear Antigen 1) region. The samples were aligned by DNASTAR program. The aligned sequences showed the base conversion G to A in seven samples. This conversion caused no alteration in the EBNA-1 protein conformation. In the phylogenetic analysis the studied sequences with the sequences from GenBank was possible to observe two groups represented with type 1 and type 2 from EBV. 100% the samples studied was identified with the group characterized by the type 2 to EBV. So the seven samples showed the conversion, suggesting the origin of the one new subtype.

Advisors/Committee Members: Edison Luiz Durigon, Charlotte Marianna Harsi, Eduardo Massad, Maria Isabel de Oliveira, Klaus Eberhard Stewien.

Subjects/Keywords: Biologia molecular; Sequenciamento genético; Virologia médica; Virologia molecular; Vírus Epstein-Barr; Vírus oncogênico; Epstein-barr virus; Genetic sequency; Medical virology; Molecular biology; Molecular virology; Oncogenic virus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rodrigues, J. N. M. (2008). Caracterização molecular do Epstein-Barr vírus (EBV) em pacientes portadores de HIV, em tratamento, atendidos no sistema hospitalar do sistema penitenciário do Estado de São Paulo. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/42/42132/tde-27032009-154240/

Chicago Manual of Style (16^th Edition):

Rodrigues, Juliana Nogueira Martins. “Caracterização molecular do Epstein-Barr vírus (EBV) em pacientes portadores de HIV, em tratamento, atendidos no sistema hospitalar do sistema penitenciário do Estado de São Paulo.” 2008. Doctoral Dissertation, University of São Paulo. Accessed April 22, 2021. http://www.teses.usp.br/teses/disponiveis/42/42132/tde-27032009-154240/.

MLA Handbook (7^th Edition):

Rodrigues, Juliana Nogueira Martins. “Caracterização molecular do Epstein-Barr vírus (EBV) em pacientes portadores de HIV, em tratamento, atendidos no sistema hospitalar do sistema penitenciário do Estado de São Paulo.” 2008. Web. 22 Apr 2021.

Vancouver:

Rodrigues JNM. Caracterização molecular do Epstein-Barr vírus (EBV) em pacientes portadores de HIV, em tratamento, atendidos no sistema hospitalar do sistema penitenciário do Estado de São Paulo. [Internet] [Doctoral dissertation]. University of São Paulo; 2008. [cited 2021 Apr 22]. Available from: http://www.teses.usp.br/teses/disponiveis/42/42132/tde-27032009-154240/.

Council of Science Editors:

Rodrigues JNM. Caracterização molecular do Epstein-Barr vírus (EBV) em pacientes portadores de HIV, em tratamento, atendidos no sistema hospitalar do sistema penitenciário do Estado de São Paulo. [Doctoral Dissertation]. University of São Paulo; 2008. Available from: http://www.teses.usp.br/teses/disponiveis/42/42132/tde-27032009-154240/

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