subject:(Oligomers)

University of Johannesburg

1. Ranwell, Alta. Die oligomerisasie van Sasol alfa-olefienfraksies.

Degree: 2014, University of Johannesburg

►

M.Sc.

The development of synthetic lubricants was the logical result of high demands being made by modern technology, the exhaustion of natural mineral oil sources… (more)

▼

M.Sc.

The development of synthetic lubricants was the logical result of high demands being made by modern technology, the exhaustion of natural mineral oil sources and the search for environmentally friendly substances. Alpha olefins are products of the Sasol Fischer-Tropsch process and are currently part of the wider petrol pool. Substantial value can be added to the alpha olefins by the production of high value polyalphaolefins (PADs). This project was aimed at finding explanations for previous unsuccessful attempts to produce acceptable PADs from Sasol feedstreams. High priority was given to the modification of experimental procedures to produce a synthetic oil that conforms to specific standards. Oxygenates, aromatics and "other than alpha" olefins (branched, internal and cyclic olefins) were identified as problem components in the Sasol feedstream. These compounds led to early termination of oligomerisation and in the presence of BF3 , unwanted compounds were even incorporated into the PAD products. The feedstream was thus purified by distillation and a MeDH/H2D extraction procedure. As a result, better reaction control (with regard to oligomer distribution) was gained and the product quality improved. Reaction conditions were optimised and basic reaction models (to predict oligomer distributions) were developed. It became clear however, that product quality did not only depend on oligomer distribution, but also on the specific structures present in the various oligomers. GC analyses showed that each oligomer consists of a great number of isomers - even more than can be explained in terms of the classic cationic mechanism for oligomerisation. GC-MS analyses could not successfully distinguish between different branched isomers, because of the complexity of the mixture. Summary The question was asked whether the complex mixture has already been formed during the primary oligomerisation process, or at a later stage by skeletal rearrangements. Research work indicated that one can distinguish between a primary (normal oligomerisation) process, and a secondary process (skeletal rearrangement). It became clear that the secondary process is favoured by specific reaction conditions (e.g. long reaction times and high co-catalyst concentrations). The formation of isomers increased under these conditions and product quality was adversely affected. The possibility to produce PAD products from Sasol feedstreams identical to commercial products still exists, and necessitate further research work.

Subjects/Keywords: Oligomers; Alkenes

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APA (6^th Edition):

Ranwell, A. (2014). Die oligomerisasie van Sasol alfa-olefienfraksies. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/11521

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ranwell, Alta. “Die oligomerisasie van Sasol alfa-olefienfraksies.” 2014. Thesis, University of Johannesburg. Accessed March 07, 2021. http://hdl.handle.net/10210/11521.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ranwell, Alta. “Die oligomerisasie van Sasol alfa-olefienfraksies.” 2014. Web. 07 Mar 2021.

Vancouver:

Ranwell A. Die oligomerisasie van Sasol alfa-olefienfraksies. [Internet] [Thesis]. University of Johannesburg; 2014. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10210/11521.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ranwell A. Die oligomerisasie van Sasol alfa-olefienfraksies. [Thesis]. University of Johannesburg; 2014. Available from: http://hdl.handle.net/10210/11521

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Oregon State University

2. Huang, Sung-ben. Synthesis and oligomerization of Delta, 4-diamino-2-oxo-1(2H)-pyrimidinehexanoic acid.

Degree: PhD, Chemistry, 1990, Oregon State University

URL: http://hdl.handle.net/1957/37376

Subjects/Keywords: Oligomers

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APA (6^th Edition):

Huang, S. (1990). Synthesis and oligomerization of Delta, 4-diamino-2-oxo-1(2H)-pyrimidinehexanoic acid. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/37376

Chicago Manual of Style (16^th Edition):

Huang, Sung-ben. “Synthesis and oligomerization of Delta, 4-diamino-2-oxo-1(2H)-pyrimidinehexanoic acid.” 1990. Doctoral Dissertation, Oregon State University. Accessed March 07, 2021. http://hdl.handle.net/1957/37376.

MLA Handbook (7^th Edition):

Huang, Sung-ben. “Synthesis and oligomerization of Delta, 4-diamino-2-oxo-1(2H)-pyrimidinehexanoic acid.” 1990. Web. 07 Mar 2021.

Vancouver:

Huang S. Synthesis and oligomerization of Delta, 4-diamino-2-oxo-1(2H)-pyrimidinehexanoic acid. [Internet] [Doctoral dissertation]. Oregon State University; 1990. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1957/37376.

Council of Science Editors:

Huang S. Synthesis and oligomerization of Delta, 4-diamino-2-oxo-1(2H)-pyrimidinehexanoic acid. [Doctoral Dissertation]. Oregon State University; 1990. Available from: http://hdl.handle.net/1957/37376

Oregon State University

3. Pullicin, Alexa. The preparation and human taste detection of low degree of polymerization glucose oligomers.

Degree: MS, 2017, Oregon State University

URL: http://hdl.handle.net/1957/61553

► There is growing evidence that humans and other animals can taste certain starch hydrolysis products, namely, maltooligosaccharides (MOS), and that their detection is independent of… (more)

▼ There is growing evidence that humans and other animals can taste certain starch hydrolysis products, namely, maltooligosaccharides (MOS), and that their detection is independent of the known sweet receptor, T1R2/T1R3. The overall goal of this study was to further investigate the taste perception of low degree-of-polymerization (DP) MOS in humans. However, research in this area is limited, presumably due to a lack of MOS with specific, narrow DP profiles that are safe for human testing. In order to achieve the overall goal, a method was first developed to prepare specific groups of food-grade MOS (DP 3, 3-4, 5-6, and 6-7) by fractionating commercial mixtures of glucose oligomers and polymers. Psychophysical testing using the four prepared MOS stimuli in addition to glucose (DP 1) and maltose (DP 2) at the same concentration showed that all six stimuli were detected with similar discriminability in normal tasting conditions. In order to assess the potential role of T1R2/T1R3 in MOS taste detection, the stimuli were additionally prepared with lactisole, a sweet inhibitor. All stimuli in both lactisole treatments were prepared with acarbose to prevent oral digestion of glucosidic bonds by salivary α-amylase. Here, it was found that subjects could not detect DP 1, 2, or 3, but could still detect the MOS mixtures (DP 3-4, 5-6, and 6-7). Together, these results support the presence of a MOS taste perception mechanism independent of the T1R2/T1R3 taste receptor, and suggest it is stimulated by MOS greater than three units. After completing psychophysical testing, modifications to the MOS fractionation protocol were found to allow isolated MOS products from DP 3 to 7 to be collected. A second study thus presents the method to obtain these isolated products in a food-safe quality. Differential solubility using aqueous ethanol is first used to obtain a refined MOS preparation, which can then be further refined using column chromatography. A cellulose-based column in conjunction with aqueous ethanol mobile phases is used to separate the MOS preparation into linear, isolated MOS DP 3 to 7 in high purity. This fractionation method will not only be of high relevance to researchers interested in studying the physiological impacts of MOS consumption in humans, but will also be useful to future studies involving human taste perception of these saccharides. Advisors/Committee Members: Lim, Juyun (advisor), Penner, Michael (committee member).

Subjects/Keywords: glucose oligomers

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APA (6^th Edition):

Pullicin, A. (2017). The preparation and human taste detection of low degree of polymerization glucose oligomers. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/61553

Chicago Manual of Style (16^th Edition):

Pullicin, Alexa. “The preparation and human taste detection of low degree of polymerization glucose oligomers.” 2017. Masters Thesis, Oregon State University. Accessed March 07, 2021. http://hdl.handle.net/1957/61553.

MLA Handbook (7^th Edition):

Pullicin, Alexa. “The preparation and human taste detection of low degree of polymerization glucose oligomers.” 2017. Web. 07 Mar 2021.

Vancouver:

Pullicin A. The preparation and human taste detection of low degree of polymerization glucose oligomers. [Internet] [Masters thesis]. Oregon State University; 2017. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1957/61553.

Council of Science Editors:

Pullicin A. The preparation and human taste detection of low degree of polymerization glucose oligomers. [Masters Thesis]. Oregon State University; 2017. Available from: http://hdl.handle.net/1957/61553

Michigan State University

4. Pasco, Susan T. Synthesis and chara[c]terization of substituted polyphenylene oligomers.

Degree: PhD, Department of Chemistry, 1997, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:27222

Subjects/Keywords: Oligomers

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APA (6^th Edition):

Pasco, S. T. (1997). Synthesis and chara[c]terization of substituted polyphenylene oligomers. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:27222

Chicago Manual of Style (16^th Edition):

Pasco, Susan T. “Synthesis and chara[c]terization of substituted polyphenylene oligomers.” 1997. Doctoral Dissertation, Michigan State University. Accessed March 07, 2021. http://etd.lib.msu.edu/islandora/object/etd:27222.

MLA Handbook (7^th Edition):

Pasco, Susan T. “Synthesis and chara[c]terization of substituted polyphenylene oligomers.” 1997. Web. 07 Mar 2021.

Vancouver:

Pasco ST. Synthesis and chara[c]terization of substituted polyphenylene oligomers. [Internet] [Doctoral dissertation]. Michigan State University; 1997. [cited 2021 Mar 07]. Available from: http://etd.lib.msu.edu/islandora/object/etd:27222.

Council of Science Editors:

Pasco ST. Synthesis and chara[c]terization of substituted polyphenylene oligomers. [Doctoral Dissertation]. Michigan State University; 1997. Available from: http://etd.lib.msu.edu/islandora/object/etd:27222

Tulane University

5. Kurnosov, Arkady. Theoretical investigation of ultrafast energy transport in polymer chains.

Degree: 2016, Tulane University

URL: https://digitallibrary.tulane.edu/islandora/object/tulane:66207

►

In the present study a few approaches are developed for theoretical investigation of vibrational energy propagation in highly ordered polymers and linear atomic chains. Density… (more)

Subjects/Keywords: ballistic transport; electronic sound; oligomers

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APA (6^th Edition):

Kurnosov, A. (2016). Theoretical investigation of ultrafast energy transport in polymer chains. (Thesis). Tulane University. Retrieved from https://digitallibrary.tulane.edu/islandora/object/tulane:66207

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kurnosov, Arkady. “Theoretical investigation of ultrafast energy transport in polymer chains.” 2016. Thesis, Tulane University. Accessed March 07, 2021. https://digitallibrary.tulane.edu/islandora/object/tulane:66207.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kurnosov, Arkady. “Theoretical investigation of ultrafast energy transport in polymer chains.” 2016. Web. 07 Mar 2021.

Vancouver:

Kurnosov A. Theoretical investigation of ultrafast energy transport in polymer chains. [Internet] [Thesis]. Tulane University; 2016. [cited 2021 Mar 07]. Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:66207.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kurnosov A. Theoretical investigation of ultrafast energy transport in polymer chains. [Thesis]. Tulane University; 2016. Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:66207

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Johannesburg

6. Deetlefs, Maggel. Oligomerization of alpha olefins with zirconium catalysts.

Degree: 2012, University of Johannesburg

URL: http://hdl.handle.net/10210/5482

►

M.Sc.

Polymerization of a-olefins by metallocene-based catalysts, is an ever expanding field with current scientific research continuing in an endeavor to develop chiral catalysts with… (more)

▼

M.Sc.

Polymerization of a-olefins by metallocene-based catalysts, is an ever expanding field with current scientific research continuing in an endeavor to develop chiral catalysts with greater stereospecificity and activities. However, the application of metallocene catalysts in oligomerization reactions of a-olefins has been somewhat neglected. This is despite the fact that metallocene catalysis can offer a convenient route to the synthesis of higher a-olefin oligomers. Furthermore, by utilizing an assortment of functional group transformations, a-olefin oligomers can serve as intermediates for a variety of specialty chemicals. Notwithstanding the possibility of employing alternative ligands in catalysis, the use of non-cyclopentadienyl-based complexes is a topic that has only recently been considered. Comparative studies of a series of analogous complexes is lacking in this field and thus a pertinent study of a number of known metallocene complexes was executed in this project. Furthermore, an industrially applicable process for oligomerization was sought after. This was in fact achieved by subjecting the a-olefins 1-pentene, 1- hexene and 1-octene, to oligomerization conditions with a previously unreported and lowered methylaluminoxane ratio. This reaction proved to be highly selective to dimer formation of the three aforementioned higher a-olefins. In order to gain more insight into the oligomerization process, the progress of the reaction was also followed. Only zirconium complexes were synthesized and furthermore, the induction of oligomerization as opposed to polymerization (using compounds known to be active solely as polymerization catalysts), was attempted by increasing the reaction temperature. The second part of this project entailed the synthesis and subsequent testing of zirconium catalysts containing non-cyclopenatadienyl-based ligands. These complexes have frameworks with chelating phenolate or naphtholate ligands. These complexes were tested for oligomerization, but results proved to be negative.

Subjects/Keywords: Oligomers.; Polymerization.; Metallocenes.; Zirconium.; Alkenes.

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APA (6^th Edition):

Deetlefs, M. (2012). Oligomerization of alpha olefins with zirconium catalysts. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/5482

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Deetlefs, Maggel. “Oligomerization of alpha olefins with zirconium catalysts.” 2012. Thesis, University of Johannesburg. Accessed March 07, 2021. http://hdl.handle.net/10210/5482.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Deetlefs, Maggel. “Oligomerization of alpha olefins with zirconium catalysts.” 2012. Web. 07 Mar 2021.

Vancouver:

Deetlefs M. Oligomerization of alpha olefins with zirconium catalysts. [Internet] [Thesis]. University of Johannesburg; 2012. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10210/5482.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Deetlefs M. Oligomerization of alpha olefins with zirconium catalysts. [Thesis]. University of Johannesburg; 2012. Available from: http://hdl.handle.net/10210/5482

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Johannesburg

7. Van Zyl, Aletta. Biphenolate and cyclopentadienyl-derived complexes of zirconium and titanium as catalysts for the polymerisation of alpha olefins.

Degree: 2012, University of Johannesburg

URL: http://hdl.handle.net/10210/6852

►

M.Sc.

An annual production of approximately 46 million metric tons of polyolefins worldwide, emphasizes the industrial importance of this product and the polymerisation process. Olefins… (more)

Subjects/Keywords: Oligomers; Polymerization; Zirconium; Alkenes; Titanium

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APA (6^th Edition):

Van Zyl, A. (2012). Biphenolate and cyclopentadienyl-derived complexes of zirconium and titanium as catalysts for the polymerisation of alpha olefins. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/6852

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Van Zyl, Aletta. “Biphenolate and cyclopentadienyl-derived complexes of zirconium and titanium as catalysts for the polymerisation of alpha olefins.” 2012. Thesis, University of Johannesburg. Accessed March 07, 2021. http://hdl.handle.net/10210/6852.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Van Zyl, Aletta. “Biphenolate and cyclopentadienyl-derived complexes of zirconium and titanium as catalysts for the polymerisation of alpha olefins.” 2012. Web. 07 Mar 2021.

Vancouver:

Van Zyl A. Biphenolate and cyclopentadienyl-derived complexes of zirconium and titanium as catalysts for the polymerisation of alpha olefins. [Internet] [Thesis]. University of Johannesburg; 2012. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10210/6852.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Van Zyl A. Biphenolate and cyclopentadienyl-derived complexes of zirconium and titanium as catalysts for the polymerisation of alpha olefins. [Thesis]. University of Johannesburg; 2012. Available from: http://hdl.handle.net/10210/6852

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Columbia University

8. Wright, Nathan Edward. Synthetic Explorations and Expeditions in the Resveratrol Class.

Degree: 2014, Columbia University

URL: https://doi.org/10.7916/D8SF2T8X

► Research interest in resveratrol, a structurally simple plant metabolite, has increased exponentially in the last two decades. Since its isolation from red wine it has… (more)

▼ Research interest in resveratrol, a structurally simple plant metabolite, has increased exponentially in the last two decades. Since its isolation from red wine it has been hypothesized that this structure may account for the so-called "French Paradox," the notion that despite a diet high in cholesterol one can enjoy a relatively healthy lifestyle through moderate red wine consumption. The biological implications of these claims are presented. Concurrently isolated along with resveratrol are hundreds of oligomeric natural products with structures varying in both size and complexity. The discovery, biosynthesis, and previous synthetic studies towards these natural products will be presented to frame the landscape of the field and its current limitations. Heimiol A and hopeahainol D are oxidized, resveratrol dimers characterized by their [3.2.2] bicyclic framework with a bridging ether. The total synthesis of these epimeric natural products was accomplished by the development of a halolactonization/Friedel-Crafts cascade to construct the bicyclic core. Subsequently, a steric bias inherent in the molecule was doubly exploited to synthesize both targets with complete selectivity. During the course of these studies, a number of unexpected results were observed which have led, or may potentially lead, to alternate courses of investigation. These results and their potential impact are also presented. Well-established in the synthetic community are the challenges associated with medium-sized ring construction. Of particularly rarity are solutions addressing all carbon 9-membered rings. Seeing this motif present in a subclass of resveratrol oligomers, we sought to investigate this challenging substructure. Our efforts to achieve this end are detailed with the successful development of two unique methods to construct the requisite 9-membered ring core. One succeeded in the first ever reported 9-exo-dig cyclization while the other enabled the robust total synthesis of caraphenol A. [1.1.1]-orthocyclophanes have received considerable attention of late due to their numerous applications in the field of supramolecular chemistry. Owing to their rigid, bowl shape, these scaffolds are capable of engaging in numerous guest-host complexes. The previous syntheses of [1.1.1]-orthocyclophanes as well as a survey of their applications are presented. In the course of our synthetic studies toward caraphenol A, we accomplished the synthesis of a unique [1.1.1]-orthocyclophane as well as the successful oxidation to its corresponding triketone. These results are presented noting that despite many efforts, no other [1.1.1]-orthocyclophane triketone has ever been successfully synthesized with our work constituting the first such report.

Subjects/Keywords: Oligomers; Resveratrol; Chemistry, Organic

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APA (6^th Edition):

Wright, N. E. (2014). Synthetic Explorations and Expeditions in the Resveratrol Class. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8SF2T8X

Chicago Manual of Style (16^th Edition):

Wright, Nathan Edward. “Synthetic Explorations and Expeditions in the Resveratrol Class.” 2014. Doctoral Dissertation, Columbia University. Accessed March 07, 2021. https://doi.org/10.7916/D8SF2T8X.

MLA Handbook (7^th Edition):

Wright, Nathan Edward. “Synthetic Explorations and Expeditions in the Resveratrol Class.” 2014. Web. 07 Mar 2021.

Vancouver:

Wright NE. Synthetic Explorations and Expeditions in the Resveratrol Class. [Internet] [Doctoral dissertation]. Columbia University; 2014. [cited 2021 Mar 07]. Available from: https://doi.org/10.7916/D8SF2T8X.

Council of Science Editors:

Wright NE. Synthetic Explorations and Expeditions in the Resveratrol Class. [Doctoral Dissertation]. Columbia University; 2014. Available from: https://doi.org/10.7916/D8SF2T8X

Columbia University

9. Chiriac, Maria Irina. Regioselective Installation of the Trans-dihydrofuran Architecture for the Synthesis of Resveratrol Oligomers.

Degree: 2014, Columbia University

URL: https://doi.org/10.7916/D80V8B35

► The family of oligomeric natural products derived from resveratrol possesses broad pharmacological potential, with the larger members of the class often displaying the most impressive… (more)

Subjects/Keywords: Oligomers – Synthesis; Resveratrol; Chemistry, Organic

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APA (6^th Edition):

Chiriac, M. I. (2014). Regioselective Installation of the Trans-dihydrofuran Architecture for the Synthesis of Resveratrol Oligomers. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D80V8B35

Chicago Manual of Style (16^th Edition):

Chiriac, Maria Irina. “Regioselective Installation of the Trans-dihydrofuran Architecture for the Synthesis of Resveratrol Oligomers.” 2014. Doctoral Dissertation, Columbia University. Accessed March 07, 2021. https://doi.org/10.7916/D80V8B35.

MLA Handbook (7^th Edition):

Chiriac, Maria Irina. “Regioselective Installation of the Trans-dihydrofuran Architecture for the Synthesis of Resveratrol Oligomers.” 2014. Web. 07 Mar 2021.

Vancouver:

Chiriac MI. Regioselective Installation of the Trans-dihydrofuran Architecture for the Synthesis of Resveratrol Oligomers. [Internet] [Doctoral dissertation]. Columbia University; 2014. [cited 2021 Mar 07]. Available from: https://doi.org/10.7916/D80V8B35.

Council of Science Editors:

Chiriac MI. Regioselective Installation of the Trans-dihydrofuran Architecture for the Synthesis of Resveratrol Oligomers. [Doctoral Dissertation]. Columbia University; 2014. Available from: https://doi.org/10.7916/D80V8B35

University of Minnesota

10. Greimel, Susan Jean. Soluble alpha-synuclein oligomers are associated with reduced synapsin expression and enhanced cognitive decline in Alzheimer's disease.

Degree: MS, Neuroscience, 2014, University of Minnesota

URL: http://hdl.handle.net/11299/162840

► We recently proposed that soluble, intraneuronal alpha-synuclein (alpha-Syn) might modulate Alzheimer's disease (AD) pathophysiology in the absence of Lewy body (LB) pathology. With mounting evidence… (more)

Subjects/Keywords: Alpha-synuclein; Alzheimer's; Oligomers; Synapsin

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APA (6^th Edition):

Greimel, S. J. (2014). Soluble alpha-synuclein oligomers are associated with reduced synapsin expression and enhanced cognitive decline in Alzheimer's disease. (Masters Thesis). University of Minnesota. Retrieved from http://hdl.handle.net/11299/162840

Chicago Manual of Style (16^th Edition):

Greimel, Susan Jean. “Soluble alpha-synuclein oligomers are associated with reduced synapsin expression and enhanced cognitive decline in Alzheimer's disease.” 2014. Masters Thesis, University of Minnesota. Accessed March 07, 2021. http://hdl.handle.net/11299/162840.

MLA Handbook (7^th Edition):

Greimel, Susan Jean. “Soluble alpha-synuclein oligomers are associated with reduced synapsin expression and enhanced cognitive decline in Alzheimer's disease.” 2014. Web. 07 Mar 2021.

Vancouver:

Greimel SJ. Soluble alpha-synuclein oligomers are associated with reduced synapsin expression and enhanced cognitive decline in Alzheimer's disease. [Internet] [Masters thesis]. University of Minnesota; 2014. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/11299/162840.

Council of Science Editors:

Greimel SJ. Soluble alpha-synuclein oligomers are associated with reduced synapsin expression and enhanced cognitive decline in Alzheimer's disease. [Masters Thesis]. University of Minnesota; 2014. Available from: http://hdl.handle.net/11299/162840

University of South Florida

11. Blair, Laura J. Age-associated increases in FKBP51 facilitate tau neurotoxicity.

Degree: 2014, University of South Florida

URL: https://scholarcommons.usf.edu/etd/5185

► Tau is a protein which regulates microtubule stability and is heavily involved in axonal transport. This stability is dynamically controlled in part by over 40… (more)

▼ Tau is a protein which regulates microtubule stability and is heavily involved in axonal transport. This stability is dynamically controlled in part by over 40 phosphorylation sites across the tau protein which allows for binding and release from the microtubules. However, if abnormal hyperphosphorylation occurs, tau dissociates from the microtubules. Once released, the microtubules become unstable and the aberrant tau mislocalizes from the axon to the somatodendric compartment, where it aggregates. These aggregates are made of many pathological forms of tau including oligomeric species, paired helical filaments, and neurofibrillary tangles, all of which have associated toxicities. Tau pathology is a hallmark of Alzheimer's disease, one of over 15 diseases known as tauopathies which present with tau pathology, all of which lack effective treatments. Heat shock protein 90 kDa (Hsp90) is a major adenosine triphosphate (ATP)-dependent regulator of non-native proteins, like misfolded tau. Although Hsp90 is able to effectively refold and degrade many aberrant proteins, it has been associated with preserving aberrant tau. In fact, inhibiting the Hsp90 ATPase activity leads to the degradation of tau, which has been demonstrated in a number of models with the use of various Hsp90 inhibitors. However, there are many side-effects associated with the use of these inhibitors including toxicity and heat shock factor 1 (HSF1) activation. Although improvements on Hsp90 inhibitors are still in progress, this study explores targeting Hsp90 through a slightly different mechanism, by targeting Hsp90 co-chaperones. Hsp90 is involved in almost every pathway in each cell throughout the body. Co-chaperone proteins assist Hsp90 in these various processes, but are each only involved in a subset of the total Hsp90 interactome. Therefore, targeting Hsp90 co-chaperones could lead to improved efficacy, potency, and safety of drugs designed toward Hsp90 for the treatment of tauopathies. We previously showed one of these co-chaperones, FK506 binding protein 51 kDa (FKBP51), a tetratricopeptide repeat (TPR) domain containing immunophilin, coordinates with Hsp90 to regulate tau metabolism. More specifically, we found that increases and decreases in FKBP51 levels correlated with increases and decreases in tau levels, respectively. FKBP51 knockout mice have been extensively studied and have shown no negative phenotypes in these characterizations. In this study, we found that this mouse model has decreased endogenous tau levels. Furthermore, this study demonstrates that FKPB51 colocalizes with pathological tau in the AD brain, and synergizes with Hsp90 to preserve tau from proteasomal degradation. Additionally, FKBP51 overexpression in mouse model of tau pathology leads to the preservation of tau. We went on to characterize this accumulated tau as being neurotoxic and oligomeric in nature, while being low in silver positive, β-sheet structure. In the human brain, we found that FKBP51 is strikingly increased with aging and even further in the AD brain.…

Subjects/Keywords: chaperones; FKBP5; Hsp90; oligomers; Neurosciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Blair, L. J. (2014). Age-associated increases in FKBP51 facilitate tau neurotoxicity. (Thesis). University of South Florida. Retrieved from https://scholarcommons.usf.edu/etd/5185

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Blair, Laura J. “Age-associated increases in FKBP51 facilitate tau neurotoxicity.” 2014. Thesis, University of South Florida. Accessed March 07, 2021. https://scholarcommons.usf.edu/etd/5185.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Blair, Laura J. “Age-associated increases in FKBP51 facilitate tau neurotoxicity.” 2014. Web. 07 Mar 2021.

Vancouver:

Blair LJ. Age-associated increases in FKBP51 facilitate tau neurotoxicity. [Internet] [Thesis]. University of South Florida; 2014. [cited 2021 Mar 07]. Available from: https://scholarcommons.usf.edu/etd/5185.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Blair LJ. Age-associated increases in FKBP51 facilitate tau neurotoxicity. [Thesis]. University of South Florida; 2014. Available from: https://scholarcommons.usf.edu/etd/5185

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

12. Hao, Yu. Synthesis and conformational studies of beta 2,3-cyclic aminoxy peptides.

Degree: 2005, University of Hong Kong

URL: http://hdl.handle.net/10722/50337

Subjects/Keywords: Oligomers.; Peptides - Synthesis.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hao, Y. (2005). Synthesis and conformational studies of beta 2,3-cyclic aminoxy peptides. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/50337

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hao, Yu. “Synthesis and conformational studies of beta 2,3-cyclic aminoxy peptides.” 2005. Thesis, University of Hong Kong. Accessed March 07, 2021. http://hdl.handle.net/10722/50337.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hao, Yu. “Synthesis and conformational studies of beta 2,3-cyclic aminoxy peptides.” 2005. Web. 07 Mar 2021.

Vancouver:

Hao Y. Synthesis and conformational studies of beta 2,3-cyclic aminoxy peptides. [Internet] [Thesis]. University of Hong Kong; 2005. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10722/50337.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hao Y. Synthesis and conformational studies of beta 2,3-cyclic aminoxy peptides. [Thesis]. University of Hong Kong; 2005. Available from: http://hdl.handle.net/10722/50337

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

13. Zhang, Yuhui. Beta-Aminoxy peptides as foldamers: synthesisand conformational studies.

Degree: 2004, University of Hong Kong

URL: http://hdl.handle.net/10722/131631

Subjects/Keywords: Amino acids.; Oligomers.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zhang, Y. (2004). Beta-Aminoxy peptides as foldamers: synthesisand conformational studies. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/131631

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhang, Yuhui. “Beta-Aminoxy peptides as foldamers: synthesisand conformational studies.” 2004. Thesis, University of Hong Kong. Accessed March 07, 2021. http://hdl.handle.net/10722/131631.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhang, Yuhui. “Beta-Aminoxy peptides as foldamers: synthesisand conformational studies.” 2004. Web. 07 Mar 2021.

Vancouver:

Zhang Y. Beta-Aminoxy peptides as foldamers: synthesisand conformational studies. [Internet] [Thesis]. University of Hong Kong; 2004. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10722/131631.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhang Y. Beta-Aminoxy peptides as foldamers: synthesisand conformational studies. [Thesis]. University of Hong Kong; 2004. Available from: http://hdl.handle.net/10722/131631

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

14. Murray, Adrian H. Synthesis and Properties of Graphyne Model Compounds and an Electrochemical Study of Substituted Pentacenes.

Degree: PhD, Department of Chemistry, 2012, University of Alberta

URL: https://era.library.ualberta.ca/files/7w62f9728

► The work described in this thesis focuses on two central topics: (1) the synthesis of carbon-rich macrocycles as model compounds of the carbon allotrope graphyne… (more)

▼ The work described in this thesis focuses on two central topics: (1) the synthesis of carbon-rich macrocycles as model compounds of the carbon allotrope graphyne and the study of their electronic properties, and (2) the electrochemical investigation of the properties of substituted pentacene molecules. To this end, Chapter 1 first offers an introduction to conjugated organic materials, focusing on acetylene-rich macrocycles. Subsequently, the theoretical structures of graphyne are introduced, and their potential properties described. Previous synthetic efforts to prepare model compounds for graphyne are also discussed. Chapter 2 focuses on the synthesis of 12,12,12-graphyne. Described first are the syntheses of small molecules based on four molecular scaffolds: (1) aryl triazenes, (2) dibromoolefins, (3) tetraethynylethenes, and (4) vinyl triflates. These molecules are characterized using standard methods, including 1H and 13C NMR, IR, and mass spectrometries. These molecules are then used as building blocks toward the synthesis of expanded radialenes, which would serve as model compounds for 12,12,12-graphyne. Chapter 3 focuses on the use of small molecules prepared in Chapter 2 as building blocks toward a series of radiaannulene oligomers, which serve as model compounds for 6,6,12-graphyne. Several synthetic routes are explored in an effort to optimize preparation of the series of radiaannulenes. The products are characterized by 1H and 13C NMR, IR and mass spectrometries, as well as by X-ray crystallography. The electronic properties are investigated using UV-vis spectroscopy and cyclic voltammetry to provide insight into the potential properties of 6,6,12-graphyne. Chapter 4 focuses on the electrochemical properties of substituted pentacenes. A brief introduction to pentacene and functionalized pentacene is provided. The syntheses of several pentacene derivatives is outlined, and the synthesis of conjugated pentacene-thiophene molecules is described. The effect of the substituents on the HOMO and LUMO energy levels and band gaps of the pentacene molecules is described, based on results from cyclic voltammetry. The thesis concludes with a brief summary, an outlook for the synthesis graphyne model compounds, and a description of how radiaannulenes might serve as useful materials in the synthesis of other conjugated organic molecules

Subjects/Keywords: Pentacene; electrochemistry; radialene; oligomers; radiaannulene; Graphyne

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Murray, A. H. (2012). Synthesis and Properties of Graphyne Model Compounds and an Electrochemical Study of Substituted Pentacenes. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/7w62f9728

Chicago Manual of Style (16^th Edition):

Murray, Adrian H. “Synthesis and Properties of Graphyne Model Compounds and an Electrochemical Study of Substituted Pentacenes.” 2012. Doctoral Dissertation, University of Alberta. Accessed March 07, 2021. https://era.library.ualberta.ca/files/7w62f9728.

MLA Handbook (7^th Edition):

Murray, Adrian H. “Synthesis and Properties of Graphyne Model Compounds and an Electrochemical Study of Substituted Pentacenes.” 2012. Web. 07 Mar 2021.

Vancouver:

Murray AH. Synthesis and Properties of Graphyne Model Compounds and an Electrochemical Study of Substituted Pentacenes. [Internet] [Doctoral dissertation]. University of Alberta; 2012. [cited 2021 Mar 07]. Available from: https://era.library.ualberta.ca/files/7w62f9728.

Council of Science Editors:

Murray AH. Synthesis and Properties of Graphyne Model Compounds and an Electrochemical Study of Substituted Pentacenes. [Doctoral Dissertation]. University of Alberta; 2012. Available from: https://era.library.ualberta.ca/files/7w62f9728

Washington State University

15. [No author]. Stability and folding of the H2A .

Degree: 2004, Washington State University

URL: http://hdl.handle.net/2376/233

Subjects/Keywords: Histones.; Oligomers.; Proteins.

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APA (6^th Edition):

author], [. (2004). Stability and folding of the H2A . (Thesis). Washington State University. Retrieved from http://hdl.handle.net/2376/233

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

author], [No. “Stability and folding of the H2A .” 2004. Thesis, Washington State University. Accessed March 07, 2021. http://hdl.handle.net/2376/233.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

author], [No. “Stability and folding of the H2A .” 2004. Web. 07 Mar 2021.

Vancouver:

author] [. Stability and folding of the H2A . [Internet] [Thesis]. Washington State University; 2004. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/2376/233.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

author] [. Stability and folding of the H2A . [Thesis]. Washington State University; 2004. Available from: http://hdl.handle.net/2376/233

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Hong Kong University of Science and Technology

16. Chan, Ka Man. Oligomeric products and formation mechanisms from acid-catalyzed reactions of methyl vinyl ketone on acidic sulfate particles.

Degree: 2013, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-7873 ; https://doi.org/10.14711/thesis-b1213719 ; http://repository.ust.hk/ir/bitstream/1783.1-7873/1/th_redirect.html

► Methyl vinyl ketone (MVK) is a key first-generation product from atmospheric isoprene photo-oxidation, especially under high-NOx conditions. In this work, acid-catalyzed reactions of gas-phase MVK… (more)

Subjects/Keywords: Volatile organic compounds ; Atmospheric aerosols ; Catalysis ; Oligomers

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APA (6^th Edition):

Chan, K. M. (2013). Oligomeric products and formation mechanisms from acid-catalyzed reactions of methyl vinyl ketone on acidic sulfate particles. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-7873 ; https://doi.org/10.14711/thesis-b1213719 ; http://repository.ust.hk/ir/bitstream/1783.1-7873/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chan, Ka Man. “Oligomeric products and formation mechanisms from acid-catalyzed reactions of methyl vinyl ketone on acidic sulfate particles.” 2013. Thesis, Hong Kong University of Science and Technology. Accessed March 07, 2021. http://repository.ust.hk/ir/Record/1783.1-7873 ; https://doi.org/10.14711/thesis-b1213719 ; http://repository.ust.hk/ir/bitstream/1783.1-7873/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chan, Ka Man. “Oligomeric products and formation mechanisms from acid-catalyzed reactions of methyl vinyl ketone on acidic sulfate particles.” 2013. Web. 07 Mar 2021.

Vancouver:

Chan KM. Oligomeric products and formation mechanisms from acid-catalyzed reactions of methyl vinyl ketone on acidic sulfate particles. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2013. [cited 2021 Mar 07]. Available from: http://repository.ust.hk/ir/Record/1783.1-7873 ; https://doi.org/10.14711/thesis-b1213719 ; http://repository.ust.hk/ir/bitstream/1783.1-7873/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chan KM. Oligomeric products and formation mechanisms from acid-catalyzed reactions of methyl vinyl ketone on acidic sulfate particles. [Thesis]. Hong Kong University of Science and Technology; 2013. Available from: http://repository.ust.hk/ir/Record/1783.1-7873 ; https://doi.org/10.14711/thesis-b1213719 ; http://repository.ust.hk/ir/bitstream/1783.1-7873/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Victoria

17. Myles, Daniel John Talbot. Part I : synthesis and characterization of sulfur-bridged oligothiophenes ; Part II : exploratory syntheses toward dioxadiazinyl radicals.

Degree: Dept. of Chemistry, 2008, University of Victoria

URL: http://hdl.handle.net/1828/651

Subjects/Keywords: Oligomers; Radicals (Chemistry)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Myles, D. J. T. (2008). Part I : synthesis and characterization of sulfur-bridged oligothiophenes ; Part II : exploratory syntheses toward dioxadiazinyl radicals. (Thesis). University of Victoria. Retrieved from http://hdl.handle.net/1828/651

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Myles, Daniel John Talbot. “Part I : synthesis and characterization of sulfur-bridged oligothiophenes ; Part II : exploratory syntheses toward dioxadiazinyl radicals.” 2008. Thesis, University of Victoria. Accessed March 07, 2021. http://hdl.handle.net/1828/651.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Myles, Daniel John Talbot. “Part I : synthesis and characterization of sulfur-bridged oligothiophenes ; Part II : exploratory syntheses toward dioxadiazinyl radicals.” 2008. Web. 07 Mar 2021.

Vancouver:

Myles DJT. Part I : synthesis and characterization of sulfur-bridged oligothiophenes ; Part II : exploratory syntheses toward dioxadiazinyl radicals. [Internet] [Thesis]. University of Victoria; 2008. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1828/651.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Myles DJT. Part I : synthesis and characterization of sulfur-bridged oligothiophenes ; Part II : exploratory syntheses toward dioxadiazinyl radicals. [Thesis]. University of Victoria; 2008. Available from: http://hdl.handle.net/1828/651

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Hong Kong University of Science and Technology

18. Kuang, Guowen PHYS. On-surface synthesis and characterization of conjugated oligomers using low temperature scanning tunneling microscopy and spectroscopy.

Degree: 2017, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-105643 ; https://doi.org/10.14711/thesis-991012563569503412 ; http://repository.ust.hk/ir/bitstream/1783.1-105643/1/th_redirect.html

► Conjugated oligomers are envisioned as basic functional units in molecular electronics, due to their versatility, flexibility and multi-functionality. There are challenges in understanding basic phenomena… (more)

▼ Conjugated oligomers are envisioned as basic functional units in molecular electronics, due to their versatility, flexibility and multi-functionality. There are challenges in understanding basic phenomena of charge transport and spin manipulation in conjugated oligomers. This thesis focuses on on-surface synthesis and functionality characterization of porphyrin-based conjugated oligomers utilizing low-temperature scanning tunneling microscopy and spectroscopy. This thesis consists of three parts: on-surface synthesis, charge transport and spin manipulation of porphyrin-based oligomers. In the part of on-surface synthesis, the biphenyl-linked porphyrin oligomers (bp-ppo) is synthesized by homo-coupling of Br₂-TPP, the phenyl-linked porphyrin oligomers (p-ppo) is synthesized by cross-coupling of Br₂-TPP and Br₂-DPP and porphyrin-dimers (ppo) can not be synthesized on surface. In the part of charge transport, we studied the charge transport behavior of bp-ppo. Firstly, the long-range nearly length-independent resonant charge transport is observed in straight bp-ppo using STM vertical manipulation technique. We found that the electrons transfer through delocalized LUMO, and the lowest attenuation factor ( β < 0.001Å^-1) of differential conductance is achieved. Secondly, the negative differential conductance (NDC) was observed in oligomers of bp-ppo with a 90°-kink, and the mechanism is proposed to be localization of delocalized molecular orbital at higher bias. In the part of spin manipulation, we studied the mediation of Fe spin by molecular backbone. Firstly, in the system of double-Fe metalated and three C-C bonds linked ppo, we found that the spin-excitation on individual spin is quenched due to the formation of spin-spin singlet by indirect coupling mediated by molecular backbone. Secondly, we demonstrated that the spin of Fe is closely related to the conformation of porphyrin hosting the Fe: the transformation from saddle to planar changes the Fe spin state from S=2 to S=1. In summary, we studied on-surface synthesis, charge transport and spin manipulation of porphyrin-based conjugated oligomers. Our results may contribute to the development of molecular electronics.

Subjects/Keywords: Conjugated oligomers ; Surfaces ; Scanning tunneling microscopy ; Porphyrins

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APA (6^th Edition):

Kuang, G. P. (2017). On-surface synthesis and characterization of conjugated oligomers using low temperature scanning tunneling microscopy and spectroscopy. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-105643 ; https://doi.org/10.14711/thesis-991012563569503412 ; http://repository.ust.hk/ir/bitstream/1783.1-105643/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kuang, Guowen PHYS. “On-surface synthesis and characterization of conjugated oligomers using low temperature scanning tunneling microscopy and spectroscopy.” 2017. Thesis, Hong Kong University of Science and Technology. Accessed March 07, 2021. http://repository.ust.hk/ir/Record/1783.1-105643 ; https://doi.org/10.14711/thesis-991012563569503412 ; http://repository.ust.hk/ir/bitstream/1783.1-105643/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kuang, Guowen PHYS. “On-surface synthesis and characterization of conjugated oligomers using low temperature scanning tunneling microscopy and spectroscopy.” 2017. Web. 07 Mar 2021.

Vancouver:

Kuang GP. On-surface synthesis and characterization of conjugated oligomers using low temperature scanning tunneling microscopy and spectroscopy. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2017. [cited 2021 Mar 07]. Available from: http://repository.ust.hk/ir/Record/1783.1-105643 ; https://doi.org/10.14711/thesis-991012563569503412 ; http://repository.ust.hk/ir/bitstream/1783.1-105643/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kuang GP. On-surface synthesis and characterization of conjugated oligomers using low temperature scanning tunneling microscopy and spectroscopy. [Thesis]. Hong Kong University of Science and Technology; 2017. Available from: http://repository.ust.hk/ir/Record/1783.1-105643 ; https://doi.org/10.14711/thesis-991012563569503412 ; http://repository.ust.hk/ir/bitstream/1783.1-105643/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Missouri University of Science and Technology

19. Rajesh, Mathur. Enzymatic synthesis and characterization of alpha-hydroxy acid and amino acid co-oligomers.

Degree: PhD, Chemistry, Missouri University of Science and Technology

URL: https://scholarsmine.mst.edu/doctoral_dissertations/1495

► "The overall objective of the study was to investigate the use of enzymatic methods to synthesize HMB and amino acid co-oligomers. As methionine and lysine… (more)

Subjects/Keywords: Co-oligomers; Chemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rajesh, M. (n.d.). Enzymatic synthesis and characterization of alpha-hydroxy acid and amino acid co-oligomers. (Doctoral Dissertation). Missouri University of Science and Technology. Retrieved from https://scholarsmine.mst.edu/doctoral_dissertations/1495

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Chicago Manual of Style (16^th Edition):

Rajesh, Mathur. “Enzymatic synthesis and characterization of alpha-hydroxy acid and amino acid co-oligomers.” Doctoral Dissertation, Missouri University of Science and Technology. Accessed March 07, 2021. https://scholarsmine.mst.edu/doctoral_dissertations/1495.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

MLA Handbook (7^th Edition):

Rajesh, Mathur. “Enzymatic synthesis and characterization of alpha-hydroxy acid and amino acid co-oligomers.” Web. 07 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Rajesh M. Enzymatic synthesis and characterization of alpha-hydroxy acid and amino acid co-oligomers. [Internet] [Doctoral dissertation]. Missouri University of Science and Technology; [cited 2021 Mar 07]. Available from: https://scholarsmine.mst.edu/doctoral_dissertations/1495.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Council of Science Editors:

Rajesh M. Enzymatic synthesis and characterization of alpha-hydroxy acid and amino acid co-oligomers. [Doctoral Dissertation]. Missouri University of Science and Technology; Available from: https://scholarsmine.mst.edu/doctoral_dissertations/1495

Note: this citation may be lacking information needed for this citation format:
No year of publication.

University of Southern California

20. Agashe, Ninad D. Oligomer formation of functional amyloid protein - Orb2A.

Degree: MS, Biochemistry and Molecular Biology, 2014, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/458986/rec/4516

► Amyloid proteins are associated with protein misfolding and aggregation diseases but also many functional amyloid proteins are discovered with physiological role. During the process of… (more)

Subjects/Keywords: amyloid; oligomers; long term memory; amphiphillic helix

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APA (6^th Edition):

Agashe, N. D. (2014). Oligomer formation of functional amyloid protein - Orb2A. (Masters Thesis). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/458986/rec/4516

Chicago Manual of Style (16^th Edition):

Agashe, Ninad D. “Oligomer formation of functional amyloid protein - Orb2A.” 2014. Masters Thesis, University of Southern California. Accessed March 07, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/458986/rec/4516.

MLA Handbook (7^th Edition):

Agashe, Ninad D. “Oligomer formation of functional amyloid protein - Orb2A.” 2014. Web. 07 Mar 2021.

Vancouver:

Agashe ND. Oligomer formation of functional amyloid protein - Orb2A. [Internet] [Masters thesis]. University of Southern California; 2014. [cited 2021 Mar 07]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/458986/rec/4516.

Council of Science Editors:

Agashe ND. Oligomer formation of functional amyloid protein - Orb2A. [Masters Thesis]. University of Southern California; 2014. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/458986/rec/4516

University of Cambridge

21. Gomez Magenti, Jorge. Reversible chemistry to control the synthesis and folding of polymeric materials.

Degree: PhD, 2020, University of Cambridge

URL: https://doi.org/10.17863/CAM.45818 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.793058

► Mimicking Nature's ability to create well-defined functional materials is a major goal in the field of polymer chemistry. Two distinct approaches are explored in this… (more)

▼ Mimicking Nature's ability to create well-defined functional materials is a major goal in the field of polymer chemistry. Two distinct approaches are explored in this work. Part I of the thesis deals with the templated synthesis of sequence-defined oligomers. The ultimate strategy to synthesize macromolecules that have a specific functionality is the selection and evolution cycle, in which template reactions amplify the most promising sequences. All the work done in the field involve biomolecules or bio-inspired systems but there are not, to the best of our knowledge, examples of purely synthetic oligomers than can undergo efficient supramolecular replication. Covalent duplex formation has risen as a promising alternative in order to ensure template saturation during the templating process. This thesis expands on this strategy. A new molecular system was designed, which comprised phenol and carboxylic acid monomers that could selectively and quantitatively couple to each other, thus ensuring duplex formation. The monomers were linked by Glaser-Hay chemistry. A homodimer and a heterodimer were used as templates to synthesize the complementary partners through a replication cycle. The conditions for the base-pair chemistry and the zip-up reactions were optimized. In an expansion of this strategy, spacer units with symmetrical chemical handles were introduced between the template and daughter strand. This helped achieve the replication of two homodimers in a single cycle. Part II of the thesis explores the synthesis of materials making use of living polymerizations and subsequent post-functionalizations in order to obtain systems that fold on themselves, forming polymer nanoparticles. This process is reminiscent of the folding of proteins to form three-dimensional tertiary structures. Since protein functionality is derived from this precise folding of the backbone into a well-defined structure, it would be of great interest to achieve control over the folding of a synthetic polymer. Benzene-1,3,5-tricarboxamide (BTA) and solubilizing units were grafted onto a polycarbonate backbone and the folding behavior of this system was investigated by circular dichroism (CD). In another part of this work, a polyacrylate chain was functionalized with a proportion of permanently anchored BTAs, and with some which were dynamically attached via thermally reversible Diels-Alder adducts. We varied the environmental parameters of the reversible reaction. We propose that this led to the anchoring position of the dynamically-attached BTA adapting to reach a more thermodynamically stable structure. CD measurements of the system were performed to investigate polymer folding as a result of environmental molecular adaptation.

Subjects/Keywords: template; replication; oligomers; polymer nanoparticles; adaptation

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APA (6^th Edition):

Gomez Magenti, J. (2020). Reversible chemistry to control the synthesis and folding of polymeric materials. (Doctoral Dissertation). University of Cambridge. Retrieved from https://doi.org/10.17863/CAM.45818 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.793058

Chicago Manual of Style (16^th Edition):

Gomez Magenti, Jorge. “Reversible chemistry to control the synthesis and folding of polymeric materials.” 2020. Doctoral Dissertation, University of Cambridge. Accessed March 07, 2021. https://doi.org/10.17863/CAM.45818 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.793058.

MLA Handbook (7^th Edition):

Gomez Magenti, Jorge. “Reversible chemistry to control the synthesis and folding of polymeric materials.” 2020. Web. 07 Mar 2021.

Vancouver:

Gomez Magenti J. Reversible chemistry to control the synthesis and folding of polymeric materials. [Internet] [Doctoral dissertation]. University of Cambridge; 2020. [cited 2021 Mar 07]. Available from: https://doi.org/10.17863/CAM.45818 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.793058.

Council of Science Editors:

Gomez Magenti J. Reversible chemistry to control the synthesis and folding of polymeric materials. [Doctoral Dissertation]. University of Cambridge; 2020. Available from: https://doi.org/10.17863/CAM.45818 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.793058

22. Swain, Jonathan. Phenylacetylene oligomers as synthetic information molecules.

Degree: PhD, 2018, University of Cambridge

URL: https://doi.org/10.17863/CAM.26464 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.753444

► Nucleic acids store genetic information in the sequence of nucleobases. Through duplex formation and template directed synthesis, the information stored in nucleic acids determines their… (more)

▼ Nucleic acids store genetic information in the sequence of nucleobases. Through duplex formation and template directed synthesis, the information stored in nucleic acids determines their three-dimensional structure and function. Nucleic acids are essential molecules for biological processes and have been used in nanotechnology. Modified nucleic acids have been synthesised that still form duplexes and can be tolerated by enzymes, suggesting that it is possible to construct a synthetic system comparable to nucleic acids, orthogonal to nucleic acids. This thesis describes the synthesis of a new class of synthetic information molecule, characterisation of the duplex forming properties, and attempts at templated oligomerisation reactions. The new synthetic information molecule is based on the phenylacetylene oligomer framework developed by Moore and co-workers. Recognition was achieved via a base-pair that is made from a single point high affinity H-bond, with phenol as the H-bond donor (D) and phosphine oxide as the H-bond acceptor (A). The Sonogashira coupling was used to construct the phenylacetylene oligomer backbone. The AA, DD and AD 2-mers were synthesised and complementary 2-mers showed cooperative duplex formation. No intramolecular H-bonding due to folding was observed in the AD mixed 2-mer. Longer oligomers were synthesised using a method of oligomerisation and chromatographic separation by reverse-phase preparatory HPLC. Homo-oligomers up to the 7-mer were isolated and binding studies between complementary all donor, all acceptor homo-oligomers showed increasing duplex stability with each additional recognition unit in the oligomer chain. Oligomers containing both acceptor and donor recognition modules in the same chain were synthesised and NMR dilution studies were used to investigate their ability to fold. Preliminary experiments were carried out to evaluate the ability of these information molecules to template oligomerisation reactions, but when reactions were carried out at concentrations low enough for a significant template effect, no coupling reactions were observed.

Subjects/Keywords: 547; Phenylacetylene; oligomers; chemistry; synthetic; information; molecules

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APA (6^th Edition):

Swain, J. (2018). Phenylacetylene oligomers as synthetic information molecules. (Doctoral Dissertation). University of Cambridge. Retrieved from https://doi.org/10.17863/CAM.26464 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.753444

Chicago Manual of Style (16^th Edition):

Swain, Jonathan. “Phenylacetylene oligomers as synthetic information molecules.” 2018. Doctoral Dissertation, University of Cambridge. Accessed March 07, 2021. https://doi.org/10.17863/CAM.26464 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.753444.

MLA Handbook (7^th Edition):

Swain, Jonathan. “Phenylacetylene oligomers as synthetic information molecules.” 2018. Web. 07 Mar 2021.

Vancouver:

Swain J. Phenylacetylene oligomers as synthetic information molecules. [Internet] [Doctoral dissertation]. University of Cambridge; 2018. [cited 2021 Mar 07]. Available from: https://doi.org/10.17863/CAM.26464 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.753444.

Council of Science Editors:

Swain J. Phenylacetylene oligomers as synthetic information molecules. [Doctoral Dissertation]. University of Cambridge; 2018. Available from: https://doi.org/10.17863/CAM.26464 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.753444

University of Texas – Austin

23. Gong, Hegui. H-bond directed self-assembly of oligomeric molecular strands and hydrogen mediated rhodium-catalyzed reductive cyclization of 1,6-enynes.

Degree: PhD, Chemistry, 2005, University of Texas – Austin

URL: http://hdl.handle.net/2152/1925

► Key structural and interactional features of the components for hydrogen bond mediated self-assembly are reviewed, with emphasis on the assembly of synthetic oligomers to form… (more)

▼ Key structural and interactional features of the components for hydrogen bond mediated self-assembly are reviewed, with emphasis on the assembly of synthetic oligomers to form duplexes and tubular structures, as well as related applications in the design of functional materials. A strategy for the preparation of molecular strands that self-assemble through the action of interstrand H-bonds to form duplex superstructures is described. Specifically, duplex oligomers based on the 3,6-diaminopyridazine hydrogen-bonding motif were designed and prepared. The mode of assembly and the thermodynamic parameters of duplex aggregation are established by X-ray crystallographic analysis, 1 H NMR dilution experiments, isothermal titration calorimetry (ITC) and vapor pressure osmometry (VPO). ITC analysis indicates a strong positive cooperative effect upon strand extension from monomer to trimer. In addition, studies toward the design of molecular strands that assemble to form tubular structures are described. Here, alkyl chains decorated with aminopyrazolone moieties were examined. In the solid state, aminopyrazolones aggregate to form either linear H-bonded tapes or discrete cyclic tetramers, as established by single crystal X-ray diffraction analysis. Evidence for cyclic aggregation in solution, though not conclusive, led us to investigate bis(aminopyrazolone) systems, whereby the energy bias between the linear and cyclic aggregation modes could potentially be magnified to favor the latter. However, single crystal X-ray diffraction analysis of S,S-dihexylpropyl bis(aminopyrazolone) reveals a double H-bonded tape. The mode of assembly in solution for the bis(aminopyrazolone) could not be established unambiguously. Finally, the use of elemental hydrogen as a terminal reductant in the rhodiumcatalyzed enantioselective reductive cyclization of 1,6-enynes is described. Whereas 1,6- enynes containing 1,2-substituted alkenes fail to provide reductive cyclization products due to competitive cycloisomerization, related alkenes in the form of conjugated enones afford reductive cyclization products in good to excellent yield and enantioselection. Advisors/Committee Members: Krische, Michael J. (advisor).

Subjects/Keywords: Hydrogen bonding; Oligomers

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APA (6^th Edition):

Gong, H. (2005). H-bond directed self-assembly of oligomeric molecular strands and hydrogen mediated rhodium-catalyzed reductive cyclization of 1,6-enynes. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/1925

Chicago Manual of Style (16^th Edition):

Gong, Hegui. “H-bond directed self-assembly of oligomeric molecular strands and hydrogen mediated rhodium-catalyzed reductive cyclization of 1,6-enynes.” 2005. Doctoral Dissertation, University of Texas – Austin. Accessed March 07, 2021. http://hdl.handle.net/2152/1925.

MLA Handbook (7^th Edition):

Gong, Hegui. “H-bond directed self-assembly of oligomeric molecular strands and hydrogen mediated rhodium-catalyzed reductive cyclization of 1,6-enynes.” 2005. Web. 07 Mar 2021.

Vancouver:

Gong H. H-bond directed self-assembly of oligomeric molecular strands and hydrogen mediated rhodium-catalyzed reductive cyclization of 1,6-enynes. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2005. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/2152/1925.

Council of Science Editors:

Gong H. H-bond directed self-assembly of oligomeric molecular strands and hydrogen mediated rhodium-catalyzed reductive cyclization of 1,6-enynes. [Doctoral Dissertation]. University of Texas – Austin; 2005. Available from: http://hdl.handle.net/2152/1925

Columbia University

24. Beecher, Alexander Nathaniel. Using atomically precise clusters to model materials.

Degree: 2016, Columbia University

URL: https://doi.org/10.7916/D8XK8FTF

► Using two different model systems, this thesis considers the old, but fascinating question: how do atoms or particles possessing a particular set of individual characteristics… (more)

▼ Using two different model systems, this thesis considers the old, but fascinating question: how do atoms or particles possessing a particular set of individual characteristics combine to form assemblies with quite distinct, ensemble characteristics, and how do those characteristics evolve as a function of the size of the assembly? For the last thirty years, numerous experiments studying the emergence of collective material properties have focused on a class of semiconducting, colloidal nanocrystals commonly known as quantum dots, which are notable for the size-dependence of their optical properties. Despite years of effort, even the most uniform quantum dot samples possess some heterogeneity in size, shape, and composition, which has prevented complete structure determination and hindered understanding of structure-property relationships. Chapter 1 of this thesis presents an approach to overcoming this challenge and reports the synthesis of a set of four, new, atomically precise cadmium selenide nanocrystal samples, which we call CdSe(350 nm), CdSe(380 nm), CdSe(408 nm), and CdSe(435 nm) after their lowest energy absorption features. We determine their structures and formulas through a combination of single crystal and powder X-ray diffraction measurements, elemental analysis, and spectroscopy. We also describe the optical properties of these samples and their sensitivity to ligand coverage, compare them to other previously reported cadmium selenide nanomaterials, and discuss ongoing experiments. Because CdSe(350 nm), CdSe(380 nm), CdSe(408 nm), and CdSe(435 nm) are atomically precise, they allow us to correlate specific structural features with material properties, which is the focus Chapter 2. Here we present a series of Raman scattering experiments designed to probe the evolution of vibrational structure with size. We find that the Cd-Se stretching region of the Raman spectra exhibits two peaks, which are assigned to primarily surface-derived and interior-derived atomic motions using density functional theory calculations. By performing variable temperature measurements, we discover that the smallest sample, CdSe(350 nm), exhibits behavior that can be well-described using a model developed for small molecules while the vibrations of the largest measured cluster, CdSe(408 nm), are better described by a model developed for bulk materials. This observation is evidence that the transition to a more bulk-like vibrational structure occurs relatively rapidly when cadmium selenide materials are approximately 2 nm in size. The emergence of collective material properties is also the subject of Chapter 3, but the topic is approached from a different perspective. Instead of focusing on a series of atomically precise clusters that differ in size, Chapter 3 presents a series of molecules composed of atomically precise clusters. We prepare octahedral hexaruthenium carbonyl clusters, [Ru₆C(CO)₁₆]²⁻, and use them as building blocks to assemble oligomers linked by single metal atom bridges. We synthesize and…

Subjects/Keywords: Cadmium selenide; Nanostructured materials; Oligomers; Oligomers – Synthesis; Microclusters; Chemistry; Materials science; Chemistry, Inorganic

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APA (6^th Edition):

Beecher, A. N. (2016). Using atomically precise clusters to model materials. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8XK8FTF

Chicago Manual of Style (16^th Edition):

Beecher, Alexander Nathaniel. “Using atomically precise clusters to model materials.” 2016. Doctoral Dissertation, Columbia University. Accessed March 07, 2021. https://doi.org/10.7916/D8XK8FTF.

MLA Handbook (7^th Edition):

Beecher, Alexander Nathaniel. “Using atomically precise clusters to model materials.” 2016. Web. 07 Mar 2021.

Vancouver:

Beecher AN. Using atomically precise clusters to model materials. [Internet] [Doctoral dissertation]. Columbia University; 2016. [cited 2021 Mar 07]. Available from: https://doi.org/10.7916/D8XK8FTF.

Council of Science Editors:

Beecher AN. Using atomically precise clusters to model materials. [Doctoral Dissertation]. Columbia University; 2016. Available from: https://doi.org/10.7916/D8XK8FTF

University of Stirling

25. West, Shauna Mhairi. Studies on the unfolding and refolding of multi-subunit proteins.

Degree: PhD, 1990, University of Stirling

URL: http://hdl.handle.net/1893/29507

► Studies on the unfolding and refolding of multi-subunit proteins have been carried out and the results obtained for translocated proteins have been compared where possible… (more)

Subjects/Keywords: Oligomers Structure.; Oligomers; Protein folding; Enzymes

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APA (6^th Edition):

West, S. M. (1990). Studies on the unfolding and refolding of multi-subunit proteins. (Doctoral Dissertation). University of Stirling. Retrieved from http://hdl.handle.net/1893/29507

Chicago Manual of Style (16^th Edition):

West, Shauna Mhairi. “Studies on the unfolding and refolding of multi-subunit proteins.” 1990. Doctoral Dissertation, University of Stirling. Accessed March 07, 2021. http://hdl.handle.net/1893/29507.

MLA Handbook (7^th Edition):

West, Shauna Mhairi. “Studies on the unfolding and refolding of multi-subunit proteins.” 1990. Web. 07 Mar 2021.

Vancouver:

West SM. Studies on the unfolding and refolding of multi-subunit proteins. [Internet] [Doctoral dissertation]. University of Stirling; 1990. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1893/29507.

Council of Science Editors:

West SM. Studies on the unfolding and refolding of multi-subunit proteins. [Doctoral Dissertation]. University of Stirling; 1990. Available from: http://hdl.handle.net/1893/29507

University of Cambridge

26. Brichtova, Eva. Studies on the physical stability of a C-terminally amidated variant of GLP-1.

Degree: MPhil, 2019, University of Cambridge

URL: https://www.repository.cam.ac.uk/handle/1810/296886

► The phenomenon of peptide and protein aggregation is of great biochemical importance. Not only is it a key feature of numerous neurodegenerative diseases such as… (more)

▼ The phenomenon of peptide and protein aggregation is of great biochemical importance. Not only is it a key feature of numerous neurodegenerative diseases such as Alzheimer's, Parkinson's or Huntington's disease, but it also plays a significant role in the manufacturing and processing of therapeutic peptides. In the process of producing pharmaceutical peptides, molecules are exposed to a wide variety of conditions, some of which enhance aggregation, such as high peptide concentrations. In addition, the long-term physical stability of therapeutic peptides is essential for storage and use of these drugs, and also influences their half-lives in vivo. Therefore, aggregation of peptide-based therapeutics remains a great challenge for the pharmaceutical industry. Aggregation is typically defined as a process involving the non-covalent association of polypeptide chains, however, in some cases aggregates can also be linked covalently. The process of aggregation proceeds via a multi-step mechanism: First, the monomeric peptide self-associates to oligomeric structures, and these can form nucleating species which then further elongate to form amyloid fibrils. When a peptide aggregates, it leads not only to the loss of its biological activity but it can also give rise to other critical problems, e.g. toxicity and immunogenicity, associated with the formation of intermediate oligomeric species. This work is focused on the C-terminal amidated analogue of the commonly used peptide therapeutic, glucagon-like peptide 1 (GLP-1). This peptide is responsible for many regulatory mechanisms affecting the level of glucose in the bloodstream. Unfortunately, it was shown that GLP-1 has a great propensity to aggregate over a wide pH range that inhibits its function. The studies presented here establish that C-terminal amidation of this peptide hormone significantly slows its fibril formation at neutral and basic pH. It was found that during the significantly prolonged lag times, small stable soluble peptide oligomers start to form. These oligomers, which were characterised using a number of different biophysical techniques, may be off-pathway species of amyloid fibril formation or products of partial peptide degradation. The aggregation kinetics were shown to differ below and above pH 8. However, it was demonstrated that oligomers formed during the process have similar structural characteristics. While amyloid fibrils have a characteristic cross β-sheet structure, the structure of small oligomers formed mainly during the lag and elongation and growth phases is highly disordered. Surprisingly, these small oligomers show a great stability. The exact role of these small, soluble disordered aggregates in fibrillation processes requires further investigation. These results contribute to the understanding of a complex pathway of aggregation and misfolding processes by providing size and structural characterization of oligomeric species formed during the lag, elongation and growth phases.

Subjects/Keywords: peptide aggregation; glucagon-like peptide 1; GLP-1; peptide therapeutics; peptide stability; off-pathway oligomers; peptide oligomers; amyloid fibrils; metastable oligomers; amyloid aggregates; peptide degradation; fibrillation; misfolding; diabetes

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APA (6^th Edition):

Brichtova, E. (2019). Studies on the physical stability of a C-terminally amidated variant of GLP-1. (Masters Thesis). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/296886

Chicago Manual of Style (16^th Edition):

Brichtova, Eva. “Studies on the physical stability of a C-terminally amidated variant of GLP-1.” 2019. Masters Thesis, University of Cambridge. Accessed March 07, 2021. https://www.repository.cam.ac.uk/handle/1810/296886.

MLA Handbook (7^th Edition):

Brichtova, Eva. “Studies on the physical stability of a C-terminally amidated variant of GLP-1.” 2019. Web. 07 Mar 2021.

Vancouver:

Brichtova E. Studies on the physical stability of a C-terminally amidated variant of GLP-1. [Internet] [Masters thesis]. University of Cambridge; 2019. [cited 2021 Mar 07]. Available from: https://www.repository.cam.ac.uk/handle/1810/296886.

Council of Science Editors:

Brichtova E. Studies on the physical stability of a C-terminally amidated variant of GLP-1. [Masters Thesis]. University of Cambridge; 2019. Available from: https://www.repository.cam.ac.uk/handle/1810/296886

University of Alberta

27. Cho, Joon. The synthesis of cross-conjugated oligo(phenyleneenediyne)s and investigation of their optical properties.

Degree: MS, Department of Chemistry, 2001, University of Alberta

URL: https://era.library.ualberta.ca/files/xd07gw25c

Subjects/Keywords: Oligomers – Optical properties.; Oligomers – Synthesis.; Palladium catalysts.

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APA (6^th Edition):

Cho, J. (2001). The synthesis of cross-conjugated oligo(phenyleneenediyne)s and investigation of their optical properties. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/xd07gw25c

Chicago Manual of Style (16^th Edition):

Cho, Joon. “The synthesis of cross-conjugated oligo(phenyleneenediyne)s and investigation of their optical properties.” 2001. Masters Thesis, University of Alberta. Accessed March 07, 2021. https://era.library.ualberta.ca/files/xd07gw25c.

MLA Handbook (7^th Edition):

Cho, Joon. “The synthesis of cross-conjugated oligo(phenyleneenediyne)s and investigation of their optical properties.” 2001. Web. 07 Mar 2021.

Vancouver:

Cho J. The synthesis of cross-conjugated oligo(phenyleneenediyne)s and investigation of their optical properties. [Internet] [Masters thesis]. University of Alberta; 2001. [cited 2021 Mar 07]. Available from: https://era.library.ualberta.ca/files/xd07gw25c.

Council of Science Editors:

Cho J. The synthesis of cross-conjugated oligo(phenyleneenediyne)s and investigation of their optical properties. [Masters Thesis]. University of Alberta; 2001. Available from: https://era.library.ualberta.ca/files/xd07gw25c

University of Florida

28. Price, Randi Sue. Excited State Properties of Organic and Organometallic Oligomers, Polymers, and Materials and Their Solid-State Applications.

Degree: PhD, Chemistry, 2013, University of Florida

URL: https://ufdc.ufl.edu/UFE0045869

► The goal of this research is to study the excited statedynamics of conjugated molecules, oligomers and polymers in the solid state andcompare these photophysical properties… (more)

Subjects/Keywords: Absorption spectra; Emission spectra; Fluorescence; Lasers; Molecules; Oligomers; Photons; Platinum; Polymers; Wavelengths; excited-state – oligomers – photophysics – polymer – solid-state

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APA (6^th Edition):

Price, R. S. (2013). Excited State Properties of Organic and Organometallic Oligomers, Polymers, and Materials and Their Solid-State Applications. (Doctoral Dissertation). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0045869

Chicago Manual of Style (16^th Edition):

Price, Randi Sue. “Excited State Properties of Organic and Organometallic Oligomers, Polymers, and Materials and Their Solid-State Applications.” 2013. Doctoral Dissertation, University of Florida. Accessed March 07, 2021. https://ufdc.ufl.edu/UFE0045869.

MLA Handbook (7^th Edition):

Price, Randi Sue. “Excited State Properties of Organic and Organometallic Oligomers, Polymers, and Materials and Their Solid-State Applications.” 2013. Web. 07 Mar 2021.

Vancouver:

Price RS. Excited State Properties of Organic and Organometallic Oligomers, Polymers, and Materials and Their Solid-State Applications. [Internet] [Doctoral dissertation]. University of Florida; 2013. [cited 2021 Mar 07]. Available from: https://ufdc.ufl.edu/UFE0045869.

Council of Science Editors:

Price RS. Excited State Properties of Organic and Organometallic Oligomers, Polymers, and Materials and Their Solid-State Applications. [Doctoral Dissertation]. University of Florida; 2013. Available from: https://ufdc.ufl.edu/UFE0045869

29. Li, Lei. Mechanism of Early Stage Abeta Amyloid Formation.

Degree: PhD, Chemistry, 2008, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1212523380

► The brains of patients with Alzheimer disease (AD) are characterized by an abundance of amyloid plaques that contain the Abeta peptide. Numerous studies have established… (more)

▼ The brains of patients with Alzheimer disease (AD) are characterized by an abundance of amyloid plaques that contain the Abeta peptide. Numerous studies have established that the soluble oligomers, and not the insoluble amyloid plaques, constitute the real culprits responsible for the AD associated neuronal death. This thesis undertakes two projects that focus on discerning the molecular mechanisms of Abeta aggregation into soluble oligomers. The first project was designed to test whether a specific hydrophobic side-chain interaction occurs during the early stages of Abeta aggregation. A working model of the Abeta amyloid fibril structure (based on solid-state NMR constraints) has the methyl group of Met35 positioned above the Phe19 aromatic ring (within 5 angstrom), and we reasoned that switching the aromatic (single) ring to a more hydrophobic (two) ring naphthyl system would stabilize this interaction and increase the random coil to beta sheet conversion that occurs during Abeta aggregation. Four modified Abeta(1-40) peptides were prepared with the Phe19 or Phe20 rings substituted with either 1- or 2-naphthyl rings. Circular dichroism revealed that the Phe19 modified peptides underwent more rapid random to beta sheet conversions. The 1H NMR spectra of the naphthyl peptides were not appreciably different from the wild-type peptide, and the chemical shift of the Met35 methyl signal did not change, suggesting that it may not reside above the naphthyl ring. These results suggest that the Phe19-Met35 interaction does not occur in the early stages of Abeta aggregation, and instead is involved in the later stages of association into beta sheet fibrils. For the second project, the goal was to determine a high-resolution structural model of the Abeta oligomer. The NMR spectra of monomers and oligomers (separated by size-exclusion chromatography) were essentially identical and consistent with random structure. However, the monomer had significantly lower surface tension and was random structured by circular dichroism, while the oligomer had higher surface tension and was beta sheet. These results suggest that the early-formed, soluble Abeta aggregates may associate into micelle-like structures and that the micelles act as reservoirs that eventually break down and lead to amyloid fibril formation. Advisors/Committee Members: Zagorski, Michael (Advisor), Burgess, James (Committee Chair).

Subjects/Keywords: Biophysics; Chemistry; A¿¿¿¿; oligomers; A¿¿¿¿ oligomers; PEPTIDES; AMYLOID; ¿¿¿¿H

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APA (6^th Edition):

Li, L. (2008). Mechanism of Early Stage Abeta Amyloid Formation. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1212523380

Chicago Manual of Style (16^th Edition):

Li, Lei. “Mechanism of Early Stage Abeta Amyloid Formation.” 2008. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 07, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1212523380.

MLA Handbook (7^th Edition):

Li, Lei. “Mechanism of Early Stage Abeta Amyloid Formation.” 2008. Web. 07 Mar 2021.

Vancouver:

Li L. Mechanism of Early Stage Abeta Amyloid Formation. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2008. [cited 2021 Mar 07]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1212523380.

Council of Science Editors:

Li L. Mechanism of Early Stage Abeta Amyloid Formation. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2008. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1212523380

Technical University of Lisbon

30. Andrade, Inês Janine Palmeiro Ribeiro. Preparação de oligómeros de quitosano pela acção conjunta de peróxido de hidrogénio e radiação micro-ondas. Estudo das propriedades antioxidantes e antibacterianas.

Degree: 2014, Technical University of Lisbon

URL: https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/6875

►

Mestrado em Engenharia Alimentar - Instituto Superior de Agronomia

Chitosan oligomers (OQ) have deserved particular attention due to their low viscosity and high solubility at… (more)

Subjects/Keywords: Cancer pagurus; chitosan oligomers; microwave radiation; antioxidant activity; antibacterial activity

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APA (6^th Edition):

Andrade, I. J. P. R. (2014). Preparação de oligómeros de quitosano pela acção conjunta de peróxido de hidrogénio e radiação micro-ondas. Estudo das propriedades antioxidantes e antibacterianas. (Thesis). Technical University of Lisbon. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/6875

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Andrade, Inês Janine Palmeiro Ribeiro. “Preparação de oligómeros de quitosano pela acção conjunta de peróxido de hidrogénio e radiação micro-ondas. Estudo das propriedades antioxidantes e antibacterianas.” 2014. Thesis, Technical University of Lisbon. Accessed March 07, 2021. https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/6875.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Andrade, Inês Janine Palmeiro Ribeiro. “Preparação de oligómeros de quitosano pela acção conjunta de peróxido de hidrogénio e radiação micro-ondas. Estudo das propriedades antioxidantes e antibacterianas.” 2014. Web. 07 Mar 2021.

Vancouver:

Andrade IJPR. Preparação de oligómeros de quitosano pela acção conjunta de peróxido de hidrogénio e radiação micro-ondas. Estudo das propriedades antioxidantes e antibacterianas. [Internet] [Thesis]. Technical University of Lisbon; 2014. [cited 2021 Mar 07]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/6875.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Andrade IJPR. Preparação de oligómeros de quitosano pela acção conjunta de peróxido de hidrogénio e radiação micro-ondas. Estudo das propriedades antioxidantes e antibacterianas. [Thesis]. Technical University of Lisbon; 2014. Available from: https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/6875

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations