subject:(Nutritional AND Metabolic Diseases)

Cal Poly

1. Shipley, William. Assessment of the effects of malaria and anemia in pregnant Malawian women before and after treatment of moderate malnutrition.

Degree: MS, Agricultural Education and Communication, 2020, Cal Poly

URL: https://digitalcommons.calpoly.edu/theses/2182 ; 10.15368/theses.2020.79

► ABSTRACT Assessment of the Effects of Malaria and Anemia in Pregnant Malawian Women Before and After Treatment of Moderate Malnutrition William Shipley Background: Moderate… (more)

▼ ABSTRACT Assessment of the Effects of Malaria and Anemia in Pregnant Malawian Women Before and After Treatment of Moderate Malnutrition William Shipley Background: Moderate acute malnutrition (MAM) can lead to adverse maternal and infant outcomes and possibly further complications. Supplementary foods or treatments with high quality nutrients should be administered to those with MAM in hopes to increase the chance of healthy maternal and infant outcomes. Sometimes supplementary food is not enough to overcome MAM and disease may play a role, particularly in pregnant malnourished women. Objective: To determine if the effects of malaria and anemia moderated the effect of nutritional treatments (one of the three given nutritional interventions) used to improve malnutrition and achieve a MUAC ≥ 23 cm during study participation. Additionally, this research serves to assess whether the relationship between malaria and anemia is associated with malnutrition status. Methods: Women were given a dose of IPTp at each antenatal visit between zero and four total IPTp doses. Infant anthropometrics – length, weight, head circumference, and MUAC were taken at birth, 6 weeks, and 3 months. Maternal hemoglobin levels were assessed at enrollment and after 10 weeks of enrollment as well as infant hemoglobin at 3 months. Anemia was defined by a hemoglobin less than 11.0 g/dL. Mild anemia was defined as hemoglobin greater than 7.0 but less than 9.9 g/dL and moderate anemia was defined by hemoglobin values 9.9 or greater but less than 11.0 g/dL. Analysis was completed using ANOVA, and if any significant differences were observed, they were compared via Tukey HSD (continuous) or Chi-squared test (categorical). Results: Total number of IPTp doses was found to be a more statistically significant predictor of maternal weight gain during treatment than timing of the doses. It stands to reason that women receiving three or more IPTp doses was the most beneficial for women during treatment as it saw the highest increases in maternal weight gain. At baseline, women that achieved a MUAC > 23 cm during the study was 32.0% (n = 1805). The greatest proportion of women, after adjustment, that achieved a MUAC ≥ 23 cm was seen in women receiving four (47.3 %) and three (37.8 %) total IPTp doses during pregnancy. Maternal weight gain correlated closely with hemoglobin at enrollment (p-value = 0.0111). Total number of IPTp doses received during pregnancy was not found to have a statistical effect on infant hemoglobin or anemia at three months. Infant length at six weeks was higher in infants from mothers that received two or three IPTp doses compared to mothers that received one IPTp dose (p-value = 0.0218). A p-value below 0.05 by total number of IPTp doses was observed for infant weight, head circumference, and MUAC at birth, six weeks, and three months. Conclusion: At least three IPTp was effective in improving maternal weight gain and achievement of MUAC > 23 cm as well as improved many infant… Advisors/Committee Members: Dr. Peggy Papathakis.

Subjects/Keywords: Nutritional and Metabolic Diseases

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APA (6^th Edition):

Shipley, W. (2020). Assessment of the effects of malaria and anemia in pregnant Malawian women before and after treatment of moderate malnutrition. (Masters Thesis). Cal Poly. Retrieved from https://digitalcommons.calpoly.edu/theses/2182 ; 10.15368/theses.2020.79

Chicago Manual of Style (16^th Edition):

Shipley, William. “Assessment of the effects of malaria and anemia in pregnant Malawian women before and after treatment of moderate malnutrition.” 2020. Masters Thesis, Cal Poly. Accessed January 28, 2021. https://digitalcommons.calpoly.edu/theses/2182 ; 10.15368/theses.2020.79.

MLA Handbook (7^th Edition):

Shipley, William. “Assessment of the effects of malaria and anemia in pregnant Malawian women before and after treatment of moderate malnutrition.” 2020. Web. 28 Jan 2021.

Vancouver:

Shipley W. Assessment of the effects of malaria and anemia in pregnant Malawian women before and after treatment of moderate malnutrition. [Internet] [Masters thesis]. Cal Poly; 2020. [cited 2021 Jan 28]. Available from: https://digitalcommons.calpoly.edu/theses/2182 ; 10.15368/theses.2020.79.

Council of Science Editors:

Shipley W. Assessment of the effects of malaria and anemia in pregnant Malawian women before and after treatment of moderate malnutrition. [Masters Thesis]. Cal Poly; 2020. Available from: https://digitalcommons.calpoly.edu/theses/2182 ; 10.15368/theses.2020.79

McMaster University

2. Yakubovich, Natalia. Alanine Transaminase and Waist to Hip Ratio as Predictors of Dysglycemia and Regression to Normoglycemia in Adult Patients with Prediabetes.

Degree: MSc, 2012, McMaster University

URL: http://hdl.handle.net/11375/12087

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Current evidence suggests that both prediabetes and diabetes can reverse to normoglycemia; however, predictors of remission of these conditions are poorly understood. We performed… (more)

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Current evidence suggests that both prediabetes and diabetes can reverse to normoglycemia; however, predictors of remission of these conditions are poorly understood. We performed analyses on 1,209 people with impaired fasting glucose and/or impaired glucose tolerance treated with placebo rosiglitazone and placebo ramipril in the DREAM trial. Normoglycemia was defined as a fasting plasma glucose <5.6 mmol/L and 2-hour plasma glucose <7.8 mmol/L on a 75 g oral glucose tolerance test (OGTT). The effects of baseline ALT and waist to hip ratio (WHR) on regression of prediabetes to normoglycemia 2 years later were found to be interdependent (p-value for interaction 0.01). Adjusted odds ratios ORs (95% CI) of regression to normoglycemia per 10 U/L increase in ALT were 0.79 (0.66-0.94) when WHR was at the mean minus 1 standard deviation (SD), 0.90 (0.80-1.02) when WHR was at the mean of 0.91, and 1.03 (0.90-1.18) when WHR was at the mean plus 1 SD. Adjusted ORs of regression to normoglycemia per 0.1 unit increase in WHR were 0.75 (0.60-0.95) when ALT was at the mean minus 1 SD, 0.91 (0.76-1.08) when ALT was at the mean of 25 U/L, and 1.09 (0.89-1.35) when ALT was at the mean plus 1 SD. Similarly, the effects of baseline ALT and WHR on AUC_{glucose0-120 min} obtained from the OGTT were found to be interdependent (p-value for interaction 0.056). A 10 U/L increase in ALT was associated with an adjusted AUC_{glucose0-120 min} increase of 19.5 (95% CI 5.3 to 33.7) min*mmol/L when WHR was at the mean minus 1 SD, 11.0 (1.4 to 20.6) min*mmol/L when WHR was at the mean of 0.91, and 2.5 (-9.2 to 14.1) min*mmol/L when WHR was at the mean plus 1 SD. A 0.1 unit increase in WHR was associated with an adjusted AUC_{glucose0-120 min} increase of 30.3 (10.2 to 50.3) min*mmol/L when ALT was at the mean minus 1 SD, 18.3 (3.8-32.9) min*mmol/L when ALT was at the mean of 25 U/L, and 6.4 (-11.5 to 24.3) min*mmol/L when ALT was at the mean plus 1 SD. In conclusion, high baseline ALT and WHR predict a lower likelihood of regression of prediabetes to normoglycemia and an increase in AUC_{glucose0-120 min} 2 years later; however, the effects of ALT and WHR on these outcomes are interdependent.

Master of Science (MSc)

Advisors/Committee Members: Gerstein, Hertzel C., Health Research Methodology.

Subjects/Keywords: fatty liver; ALT; diabetes; normoglycemia; anthropometrics; glucose; Nutritional and Metabolic Diseases; Nutritional and Metabolic Diseases

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APA (6^th Edition):

Yakubovich, N. (2012). Alanine Transaminase and Waist to Hip Ratio as Predictors of Dysglycemia and Regression to Normoglycemia in Adult Patients with Prediabetes. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/12087

Chicago Manual of Style (16^th Edition):

Yakubovich, Natalia. “Alanine Transaminase and Waist to Hip Ratio as Predictors of Dysglycemia and Regression to Normoglycemia in Adult Patients with Prediabetes.” 2012. Masters Thesis, McMaster University. Accessed January 28, 2021. http://hdl.handle.net/11375/12087.

MLA Handbook (7^th Edition):

Yakubovich, Natalia. “Alanine Transaminase and Waist to Hip Ratio as Predictors of Dysglycemia and Regression to Normoglycemia in Adult Patients with Prediabetes.” 2012. Web. 28 Jan 2021.

Vancouver:

Yakubovich N. Alanine Transaminase and Waist to Hip Ratio as Predictors of Dysglycemia and Regression to Normoglycemia in Adult Patients with Prediabetes. [Internet] [Masters thesis]. McMaster University; 2012. [cited 2021 Jan 28]. Available from: http://hdl.handle.net/11375/12087.

Council of Science Editors:

Yakubovich N. Alanine Transaminase and Waist to Hip Ratio as Predictors of Dysglycemia and Regression to Normoglycemia in Adult Patients with Prediabetes. [Masters Thesis]. McMaster University; 2012. Available from: http://hdl.handle.net/11375/12087

University of Nevada – Las Vegas

3. Jin, Hongbin. Utilization of a Metabolic Syndrome Index in Evaluating the Life in Balance Lifestyle Intervention for Prevention of Type 2 Diabetes among Urban American Indians and Alaska Natives.

Degree: MPH, Epidemiology and Biostatistics, 2012, University of Nevada – Las Vegas

URL: https://digitalscholarship.unlv.edu/thesesdissertations/1675

► Background: A myriad of diabetes prevention programs modeled on the Diabetes Prevention Program (DPP) are carried out worldwide to fight against the current diabetes… (more)

▼ Background: A myriad of diabetes prevention programs modeled on the Diabetes Prevention Program (DPP) are carried out worldwide to fight against the current diabetes pandemic. The percentage of weight reduction is a widely used indicator to evaluate diabetes prevention programs. However, weight change alone may not fully reflect the efficacy of lifestyle intervention. A metabolic syndrome index is a promising novel scale for evaluation of diabetes prevention programs because it is a systematic, comprehensive, and stable indicator that reflects the metabolic risk reduction for diabetes and its complications at multiple levels and dimensions. Methods: A total of 22 overweight and obese AI/ANs (age, 39.6 ± 10.4 years; BMI, 34.1± 6.3 kg/m2) at increased risk for developing type 2 diabetes residing in Las Vegas participated in the LIB program between April, 2010 and December, 2011. Metabolic syndrome was defined according to the American Heart Association and the National Heart, Lung, and Blood Institute criteria. Clinical measures were collected at three different points in time before and after the completion of the LIB lifestyle core curriculum and the end of post-program follow-up. Results: Only 12 of the 22 participants completed the whole LIB program. Among the five metabolic syndrome components, only waist circumference demonstrated a significant correlation with weight. After a mean follow-up interval of 10.4 months, the metabolic syndrome index was reduced by 11% at the completion of the LIB program. The study population demonstrated significant decreased waist circumference and elevated HDL cholesterol. Triglycerides manifested the highest percentage change without statistical significance. No significant change was observed in blood pressure and fasting blood glucose. Conclusions: These findings imply that the application of a metabolic syndrome index provides more detailed information than weight in evaluating diabetes prevention programs by analyzing pre-post changes in multiple diabetes markers, particularly when the target population has normal to slightly elevated BMI. Additionally, the changes in metabolic syndrome components outline the characteristics of diabetes prevention programs, showing great potential for helping public health professionals to individualize and optimize program curriculums for different target populations. Promotion of metabolic syndrome index in diabetes research will establish a unified criterion in evaluating diabetes prevention programs and facilitate efficacy comparison among different programs. Advisors/Committee Members: Michelle Chino, Sheniz Moonie, Tim Bungum, Daniel Benyshek.

Subjects/Keywords: Community Health and Preventive Medicine; Nutritional and Metabolic Diseases; Public Health

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APA (6^th Edition):

Jin, H. (2012). Utilization of a Metabolic Syndrome Index in Evaluating the Life in Balance Lifestyle Intervention for Prevention of Type 2 Diabetes among Urban American Indians and Alaska Natives. (Masters Thesis). University of Nevada – Las Vegas. Retrieved from https://digitalscholarship.unlv.edu/thesesdissertations/1675

Chicago Manual of Style (16^th Edition):

Jin, Hongbin. “Utilization of a Metabolic Syndrome Index in Evaluating the Life in Balance Lifestyle Intervention for Prevention of Type 2 Diabetes among Urban American Indians and Alaska Natives.” 2012. Masters Thesis, University of Nevada – Las Vegas. Accessed January 28, 2021. https://digitalscholarship.unlv.edu/thesesdissertations/1675.

MLA Handbook (7^th Edition):

Jin, Hongbin. “Utilization of a Metabolic Syndrome Index in Evaluating the Life in Balance Lifestyle Intervention for Prevention of Type 2 Diabetes among Urban American Indians and Alaska Natives.” 2012. Web. 28 Jan 2021.

Vancouver:

Jin H. Utilization of a Metabolic Syndrome Index in Evaluating the Life in Balance Lifestyle Intervention for Prevention of Type 2 Diabetes among Urban American Indians and Alaska Natives. [Internet] [Masters thesis]. University of Nevada – Las Vegas; 2012. [cited 2021 Jan 28]. Available from: https://digitalscholarship.unlv.edu/thesesdissertations/1675.

Council of Science Editors:

Jin H. Utilization of a Metabolic Syndrome Index in Evaluating the Life in Balance Lifestyle Intervention for Prevention of Type 2 Diabetes among Urban American Indians and Alaska Natives. [Masters Thesis]. University of Nevada – Las Vegas; 2012. Available from: https://digitalscholarship.unlv.edu/thesesdissertations/1675

University of Western Ontario

4. Burke, Amy C. Attenuation of Obesity, Hepatic Steatosis and Reversal of Atherosclerosis by the Flavonoids Naringenin and Nobiletin.

Degree: 2018, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/5560

► Naringenin and nobiletin are naturally-derived citrus flavonoids that have significant lipid-lowering and insulin sensitizing effects in vitro and in vivo. In murine models of obesity,… (more)

▼ Naringenin and nobiletin are naturally-derived citrus flavonoids that have significant lipid-lowering and insulin sensitizing effects in vitro and in vivo. In murine models of obesity, metabolic dysfunction and atherogenesis, these flavonoids protect against the development of cardiometabolic disease. However, the ability of naringenin and nobiletin to reverse existing metabolic dysfunction and atherosclerosis has not been investigated. The purpose of this thesis was to investigate the ability of the citrus flavonoids, naringenin and nobiletin, to reverse obesity, metabolic syndrome and atherosclerosis in two different mouse models of atherosclerosis regression. The first chapter demonstrates in Ldlr-/- mice with diet-induced obesity, metabolic syndrome and atherosclerosis, that the addition of either naringenin or nobiletin to the high-fat diet completely reverses obesity and insulin resistance, and improves hyperlipidemia, hepatic steatosis and monocytosis. This leads to an improvement in lesion morphology, consistent with regression but no attenuation in plaque size. The second chapter built upon these studies by looking at the effects of naringenin in a more aggressive mouse model of atherosclerosis regression. Ldlr-/- mice with diet-induced metabolic dysfunction and atherosclerosis were intervened with chow diet supplemented with naringenin. Naringenin enhanced the reversal of obesity, hyperlipidemia, insulin resistance and monocytosis compared to intervention with chow alone. Lesions in the naringenin-treated mice were smaller, comprised of less macrophages and had more characteristics of increased lesion stability compared to lesions in mice intervened with chow alone. The third chapter further investigated the effects of naringenin in the absence of high-fat feeding. In lean, pair-fed Ldlr-/- mice, naringenin supplementation reduced adiposity, enhanced insulin sensitivity and lowered plasma lipids. Mechanistically, these metabolic improvements were due in part to enhanced energy expenditure and increased hepatic fatty acid oxidation, in the absence of obesity or high-fat feeding. In summary, the studies in this thesis provide evidence and molecular insight into how treatment with citrus flavonoids can reverse metabolic dysfunction and contribute to the regression of atherosclerosis in a mouse model. Furthermore, this thesis highlights the therapeutic utility of naringenin and nobiletin, and further underscores their importance in future therapeutic development for metabolic syndrome and atherosclerosis.

Subjects/Keywords: Atherosclerosis; Regression; Citrus Flavonoids; Metabolic Syndrome; Obesity; Ldlr-/- mice; Cardiovascular Diseases; Medicine and Health Sciences; Nutritional and Metabolic Diseases

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APA (6^th Edition):

Burke, A. C. (2018). Attenuation of Obesity, Hepatic Steatosis and Reversal of Atherosclerosis by the Flavonoids Naringenin and Nobiletin. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/5560

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Burke, Amy C. “Attenuation of Obesity, Hepatic Steatosis and Reversal of Atherosclerosis by the Flavonoids Naringenin and Nobiletin.” 2018. Thesis, University of Western Ontario. Accessed January 28, 2021. https://ir.lib.uwo.ca/etd/5560.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Burke, Amy C. “Attenuation of Obesity, Hepatic Steatosis and Reversal of Atherosclerosis by the Flavonoids Naringenin and Nobiletin.” 2018. Web. 28 Jan 2021.

Vancouver:

Burke AC. Attenuation of Obesity, Hepatic Steatosis and Reversal of Atherosclerosis by the Flavonoids Naringenin and Nobiletin. [Internet] [Thesis]. University of Western Ontario; 2018. [cited 2021 Jan 28]. Available from: https://ir.lib.uwo.ca/etd/5560.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Burke AC. Attenuation of Obesity, Hepatic Steatosis and Reversal of Atherosclerosis by the Flavonoids Naringenin and Nobiletin. [Thesis]. University of Western Ontario; 2018. Available from: https://ir.lib.uwo.ca/etd/5560

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

5. Qasim, Kashmala. ROLE OF PRE-OPERATIVE WEIGHT, DEPRESSION, SELF-ESTEEM AND HISTORY OF SEXUAL ABUSE IN PREDICTING WEIGHT LOSS AFTER GASTRIC BYPASS.

Degree: MSc, 2013, McMaster University

URL: http://hdl.handle.net/11375/13495

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Background: The objective of this thesis was to examine the role of psychosocial factors in weight loss success after bariatric surgery. It was proposed… (more)

Subjects/Keywords: Obesity; Bariatric Surgery; Roux en y Gastric Bypass; Psychosocial Factors; Body Mass Index; Depression; Nutritional and Metabolic Diseases; Psychiatric and Mental Health; Surgery; Nutritional and Metabolic Diseases

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APA (6^th Edition):

Qasim, K. (2013). ROLE OF PRE-OPERATIVE WEIGHT, DEPRESSION, SELF-ESTEEM AND HISTORY OF SEXUAL ABUSE IN PREDICTING WEIGHT LOSS AFTER GASTRIC BYPASS. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/13495

Chicago Manual of Style (16^th Edition):

Qasim, Kashmala. “ROLE OF PRE-OPERATIVE WEIGHT, DEPRESSION, SELF-ESTEEM AND HISTORY OF SEXUAL ABUSE IN PREDICTING WEIGHT LOSS AFTER GASTRIC BYPASS.” 2013. Masters Thesis, McMaster University. Accessed January 28, 2021. http://hdl.handle.net/11375/13495.

MLA Handbook (7^th Edition):

Qasim, Kashmala. “ROLE OF PRE-OPERATIVE WEIGHT, DEPRESSION, SELF-ESTEEM AND HISTORY OF SEXUAL ABUSE IN PREDICTING WEIGHT LOSS AFTER GASTRIC BYPASS.” 2013. Web. 28 Jan 2021.

Vancouver:

Qasim K. ROLE OF PRE-OPERATIVE WEIGHT, DEPRESSION, SELF-ESTEEM AND HISTORY OF SEXUAL ABUSE IN PREDICTING WEIGHT LOSS AFTER GASTRIC BYPASS. [Internet] [Masters thesis]. McMaster University; 2013. [cited 2021 Jan 28]. Available from: http://hdl.handle.net/11375/13495.

Council of Science Editors:

Qasim K. ROLE OF PRE-OPERATIVE WEIGHT, DEPRESSION, SELF-ESTEEM AND HISTORY OF SEXUAL ABUSE IN PREDICTING WEIGHT LOSS AFTER GASTRIC BYPASS. [Masters Thesis]. McMaster University; 2013. Available from: http://hdl.handle.net/11375/13495

6. Olver, Terry D. Nerve Blood Flow Control in Health & Disease:The Effects of Type 1 Diabetes and Exercise Training.

Degree: 2014, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/2109

► Peripheral nerve blood flow (NBF) is critical to nerve health. Impaired NBF control may contribute to the progression of diabetes peripheral neuropathy. The purposes of… (more)

▼ Peripheral nerve blood flow (NBF) is critical to nerve health. Impaired NBF control may contribute to the progression of diabetes peripheral neuropathy. The purposes of this dissertation were: i) to investigate the acute and chronic effects of hyperglycemia on basal sciatic NBF (measured via Doppler ultrasound), ii) to examine the potential vasodilatory effects of insulin (euglycemic hyperinsulinemic clamp; 10 mµ•kg-1•min-1) on NBF control in healthy rats and rats with insulin-treated type 1 diabetes (DS) and iii) to determine if exercise training (~75% VO2max, 60 min/day, 5 days/wk for 10 wk) improves vasa nervorum reactivity to insulin and motor nerve conduction velocity (MNCV) in rats with DS. The studies tested the overall hypotheses that i) basal NBF, the vasodilatory response to insulin, and MNCV would be attenuated in rats with DS, and ii) DS-induced deficits would be offset by concurrent exercise training. Rats with DS were hypertensive and featured reduced MNCV (P<0.01). However, DS did not alter: basal NBF; the relationship between NBF and blood pressure; or the vascularization of the sciatic nerve compared to healthy controls (P≥0.50). Based on these data, hypertensive rats with DS may exhibit elevated NBF in the conscious, basal state (P=0.02). Despite similar or possibly elevated basal NBF values compared with control rats, rats with DS displayed impaired insulin-mediated vasodilation (P≤0.01). Deficits in insulin-mediated vasa nervorum dilation and MNCV were prevented by concurrent endurance exercise training in a separate group of rats with DS. Enhanced insulin-mediated vasa nervorum dilation in aerobically exercise trained rats with DS may be explained partially by the observed increase in sciatic nerve endothelial NO synthase expression (P=0.04). The degree of hyperglycemia was similar in both groups with DS, but exogenous insulin requirements were reduced in rats with DS that exercise trained (P=0.02). Perhaps increased insulin sensitivity, and not reduced hyperglycemia, is the mechanism responsible for preserving vasa nervorum and nerve function in exercise-trained rats with DS. Improved insulin signaling in the vasa nervorum may potentiate insulin signaling in the sciatic nerve and protect against diabetic peripheral neuropathy. Keywords: nerve blood flow, diabetes, hypertension, exercise training, insulin, NO

Subjects/Keywords: nerve blood flow; diabetes; hypertension; exercise training; insulin; NO; Cardiovascular Diseases; Nervous System Diseases; Nutritional and Metabolic Diseases; Physiological Processes

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APA (6^th Edition):

Olver, T. D. (2014). Nerve Blood Flow Control in Health & Disease:The Effects of Type 1 Diabetes and Exercise Training. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/2109

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Olver, Terry D. “Nerve Blood Flow Control in Health & Disease:The Effects of Type 1 Diabetes and Exercise Training.” 2014. Thesis, University of Western Ontario. Accessed January 28, 2021. https://ir.lib.uwo.ca/etd/2109.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Olver, Terry D. “Nerve Blood Flow Control in Health & Disease:The Effects of Type 1 Diabetes and Exercise Training.” 2014. Web. 28 Jan 2021.

Vancouver:

Olver TD. Nerve Blood Flow Control in Health & Disease:The Effects of Type 1 Diabetes and Exercise Training. [Internet] [Thesis]. University of Western Ontario; 2014. [cited 2021 Jan 28]. Available from: https://ir.lib.uwo.ca/etd/2109.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Olver TD. Nerve Blood Flow Control in Health & Disease:The Effects of Type 1 Diabetes and Exercise Training. [Thesis]. University of Western Ontario; 2014. Available from: https://ir.lib.uwo.ca/etd/2109

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

7. Harlow, Brittany Elizabeth Davis. IMPACT OF STARCH SOURCE ON EQUINE HINDGUT MICROBIAL ECOLOGY.

Degree: 2015, University of Kentucky

URL: https://uknowledge.uky.edu/animalsci_etds/55

► Grain inclusion in equine diets can allow starch to reach the hindgut where bacteria compete for the substrate. The hypothesis was that starch introduction would… (more)

▼ Grain inclusion in equine diets can allow starch to reach the hindgut where bacteria compete for the substrate. The hypothesis was that starch introduction would cause a source-dependent press disturbance in equine fecal microflora. Fecal cell suspensions were prepared by differential centrifugation and re-suspension in media with ground corn, oats or wheat. At 24 h, corn had more amylolytics and Group D Gram-positive cocci (GPC), and fewer lactate-utilizing (LU) bacteria and lactobacilli than oats, with wheat being intermediate. Predominant amylolytics were identified by their 16S RNA gene sequence as Enterococcus faecalis (corn, wheat) and Streptococcus bovis (oats). In an in vivo experiment, 30 horses were assigned to 1 of 6 treatments: CO (hay only), HC (high corn), HO (high oats), LC (low corn), LO (low oats), and LW (low wheat middlings). The study consisted of a 2 wk adaptation (forage only diet) followed by a 2 wk treatment period, during which horses were adapted to their final starch intake (high, 2 g kg BW-1; low, 1 g kg BW-1). Both HC and LC had fewer lactobacilli and LU and more GPC than CO. In contrast, LO and HO had more lactobacilli and LU, and fewer GPC. LW had higher lactobacilli and GPC than CO. The highest number of amylolytics was observed in HC, followed by LC and LW. The predominant amylolytic isolates from corn and wheat horses were E. faecalis. Both experiments identified a negative correlation between lactobacilli and amylolytics, indicating a potential competitive relationship (r = -0.89, in vitro; r = -0.95, in vivo). The next experiment was conducted to determine if a Lactobacillus addition would mitigate amylolytic proliferation, specifically GPC, with corn fermentation. This experiment was conducted as described above with ground corn ± live or dead (autoclaved) L. reuteri. The addition of L. reuteri, regardless of viability, decreased amylolytics and GPC. To identify the mechanism of action, an E. faecalis isolate was co-incubated with dead L. reuteri cells or supernatant. The supernatant depleted the intracellular K+ of E. faecalis. This result demonstrates that one aspect of competition between lactobacilli and enterococci could be a membrane active antimicrobial.

Subjects/Keywords: starch; amylolytic; enterococcus; competition; hindgut acidosis; equine; Animal Diseases; Animals; Bacteria; Digestive System; Digestive System Diseases; Nutritional and Metabolic Diseases

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APA (6^th Edition):

Harlow, B. E. D. (2015). IMPACT OF STARCH SOURCE ON EQUINE HINDGUT MICROBIAL ECOLOGY. (Doctoral Dissertation). University of Kentucky. Retrieved from https://uknowledge.uky.edu/animalsci_etds/55

Chicago Manual of Style (16^th Edition):

Harlow, Brittany Elizabeth Davis. “IMPACT OF STARCH SOURCE ON EQUINE HINDGUT MICROBIAL ECOLOGY.” 2015. Doctoral Dissertation, University of Kentucky. Accessed January 28, 2021. https://uknowledge.uky.edu/animalsci_etds/55.

MLA Handbook (7^th Edition):

Harlow, Brittany Elizabeth Davis. “IMPACT OF STARCH SOURCE ON EQUINE HINDGUT MICROBIAL ECOLOGY.” 2015. Web. 28 Jan 2021.

Vancouver:

Harlow BED. IMPACT OF STARCH SOURCE ON EQUINE HINDGUT MICROBIAL ECOLOGY. [Internet] [Doctoral dissertation]. University of Kentucky; 2015. [cited 2021 Jan 28]. Available from: https://uknowledge.uky.edu/animalsci_etds/55.

Council of Science Editors:

Harlow BED. IMPACT OF STARCH SOURCE ON EQUINE HINDGUT MICROBIAL ECOLOGY. [Doctoral Dissertation]. University of Kentucky; 2015. Available from: https://uknowledge.uky.edu/animalsci_etds/55

8. Padilha, Estela Maura. Perfil epidemiológico do beribéri notificado de 2006 a 2008 no estado do Maranhão, Brasil e as ações de enfrentamento.

Degree: Mestrado, Cuidado em Saúde, 2010, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/7/7141/tde-13072010-081806/ ;

► Introdução: Beribéri é uma doença causada pela deficiência de tiamina (vitamina B1) que, apesar de facilmente tratável, pode levar a óbito. Há pelo menos setenta… (more)

▼ Introdução: Beribéri é uma doença causada pela deficiência de tiamina (vitamina B1) que, apesar de facilmente tratável, pode levar a óbito. Há pelo menos setenta anos não se tinha referência de surtos de beribéri no Brasil. Objetivo: Descrever o perfil epidemiológico dos casos de beribéri e óbitos notificados no Estado do Maranhão. Método: Estudo descritivo-retrospectivo que analisou 1.207 casos notificados de beribéri e 40 óbitos ocorridos no Maranhão no período de 2006 a 2008. As informações foram obtidas do banco de dados da Vigilância Epidemiológica e fichas de notificação. Resultados: Os casos distribuíram-se em 434 (36,0%) em 2006, 551 (45,6%) em 2007 e 222 (18,4%) em 2008. Afetou dois terços das Unidades Regionais de Saúde e 26,3% dos municípios localizados nas regiões centro-oeste, noroeste e sudoeste do Estado. As notificações foram maiores nos meses de março a agosto, com pico em junho. O coeficiente de incidência no período foi de 4,32/10.000 hab. Homens foram mais acometidos (81,9%), com concentração de casos na faixa etária de 20-40 anos (57,0%). Predominou a ocorrência do beribéri seco (84,6%) e o tempo decorrido entre os primeiros sintomas e a notificação foi inferior a três meses para dois terços dos casos. A hospitalização ocorreu para 50% dos casos em 2006, 30% em 2007 e 15% em 2008. O consumo de álcool foi referido por 53,2% dos acometidos em 2006, com proporção discretamente menor nos anos subseqüentes, e o hábito de fumar por cerca de um terço dos acometidos. Sintomas mais comuns foram: diminuição da força, dormência e edema das pernas, dificuldade para caminhar e dor na panturrilha. Em relação à escolaridade, constatou-se que mais da metade (57,2%) tinha quatro anos ou menos de estudo, dois terços (66,2%) desempenhava atividade laboral pesada e 72,9% tinham renda familiar inferior a um salário mínimo. Foram registrados 40 óbitos (3,3% do total de casos notificados) apenas em 2006, concentrados no mês de junho (61,9%) e distribuídos em 21 municípios (9,7%). A taxa de mortalidade para o Estado foi de 0,45/10.000 hab. Praticamente a totalidade dos óbitos ocorreu no sexo masculino (97,5%), sendo 72,5% na faixa etária de 20-30 anos. Para dois terços, o tempo decorrido entre os primeiros sintomas e a notificação foi inferior a três meses e a hospitalização ocorreu para 42,5%. Hábito de consumir álcool e fumar foi elevado entre aqueles que foram a óbito, 75,0% e 66,7%, respectivamente. Conclusão: O estudo se destaca por abranger análise de todas as notificações de beribéri do estado do Maranhão. Constatou-se que os casos e óbitos apresentaram distribuição espacial e temporal relacionado à realidade do estado. A ausência de óbitos em 2007 e 2008 e redução dos casos em 2008 sugerem efeitos positivos das ações de enfretamento governamentais implementadas. Esta avaliação descritiva é importante para nortear as atividades e áreas a serem priorizadas no planejamento das ações de combate, tanto no nível central (federal, estadual e municipal), como para os profissionais da atenção básica e especializada, no… Advisors/Committee Members: Fujimori, Elizabeth.

Subjects/Keywords: Descriptive epidemiology; Doenças nutricionais e metabólicas; Epidemiologia descritiva; Nutritional and metabolic diseases; Vitaminas; Vitamins

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APA (6^th Edition):

Padilha, E. M. (2010). Perfil epidemiológico do beribéri notificado de 2006 a 2008 no estado do Maranhão, Brasil e as ações de enfrentamento. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/7/7141/tde-13072010-081806/ ;

Chicago Manual of Style (16^th Edition):

Padilha, Estela Maura. “Perfil epidemiológico do beribéri notificado de 2006 a 2008 no estado do Maranhão, Brasil e as ações de enfrentamento.” 2010. Masters Thesis, University of São Paulo. Accessed January 28, 2021. http://www.teses.usp.br/teses/disponiveis/7/7141/tde-13072010-081806/ ;.

MLA Handbook (7^th Edition):

Padilha, Estela Maura. “Perfil epidemiológico do beribéri notificado de 2006 a 2008 no estado do Maranhão, Brasil e as ações de enfrentamento.” 2010. Web. 28 Jan 2021.

Vancouver:

Padilha EM. Perfil epidemiológico do beribéri notificado de 2006 a 2008 no estado do Maranhão, Brasil e as ações de enfrentamento. [Internet] [Masters thesis]. University of São Paulo; 2010. [cited 2021 Jan 28]. Available from: http://www.teses.usp.br/teses/disponiveis/7/7141/tde-13072010-081806/ ;.

Council of Science Editors:

Padilha EM. Perfil epidemiológico do beribéri notificado de 2006 a 2008 no estado do Maranhão, Brasil e as ações de enfrentamento. [Masters Thesis]. University of São Paulo; 2010. Available from: http://www.teses.usp.br/teses/disponiveis/7/7141/tde-13072010-081806/ ;

University of Louisville

9. Majumder, Avisek. Effects of hydrogen sulfide in hyperhomocysteinemia-mediated skeletal muscle myopathy.

Degree: PhD, 2018, University of Louisville

URL: 10.18297/etd/3114 ; https://ir.library.louisville.edu/etd/3114

► Although hyperhomocysteinemia (HHcy) occurs due to a deficiency in cystathionine-β-synthase (CBS), causing skeletal muscle myopathy, it is still unclear whether this effect is mediated… (more)

▼ Although hyperhomocysteinemia (HHcy) occurs due to a deficiency in cystathionine-β-synthase (CBS), causing skeletal muscle myopathy, it is still unclear whether this effect is mediated through oxidative, endoplasmic reticulum (ER) stress, both or something else. Cystathionine γ-lyase (CSE) and CBS are the main H₂S producing enzymes, which produce Hydrogen sulfide (H₂S) from Hcy in the transsulfuration reaction. H₂S is an anti-oxidant compound and patients with a CBS deficiency cannot produce enough H₂S, thus rendering them vulnerable to excess Hcy-mediated damage. Both in-vitro (C2C12 cells) and in-vivo (CBS+/- mice) models were used to study HHcy-mediated muscle myopathy, and they were treated with sodium hydrogen sulfide (NaHS, an H₂S donor) to mitigate the effect(s) of HHcy in skeletal muscle. To examine whether muscle myopathy is due to poor angiogenesis, we created a hind limb femoral artery ligation (FAL) in CBS^+/- mouse model and treated them with GYY4137 (a long-acting H₂S donor compound). Results showed that oxidative stress was reversed by NaHS (H₂S donor) in Hcy-treated C2C12 cells. ER stress markers (GRP78, ATF6, and pIRE1α) were elevated both in-vivo and in-vitro, and NaHS mitigated these effects. JNK-phosphorylation was upregulated in C2C12 cells after Hcy treatment, but NaHS could not reduce this effect. Apoptosis was induced after Hcy treatment, and it was mitigated by the NaHS supplementation in C2C12 cells. HIF1-α, VEGF, PPAR-γ and p-eNOS expression levels were attenuated in skeletal muscle of CBS+/- mice after 21 days of FAL in comparison to WT mice and were improved via the GYY4137 (another H₂S donor compound) treatment. Collateral vessel density and blood flow were significantly reduced in post-FAL CBS+/- mice compared to WT mice, and these effects were ameliorated by the GYY4137 treatment. Plasma nitrite levels were decreased in post-FAL CBS+/- mice compared to WT mice, and these were improved by GYY4137 supplementation. I also noticed FOXO1-mediated MuRF-1 upregulation, which further degrades MHC-I in CBS+/- mice compared to WT mice, and these effects were improved by NaHS intervention. Functional studies revealed that NaHS administration improved muscle fatigability in CBS+/- mice. This work provides evidence that H₂S is beneficial in mitigating HHcy-mediated skeletal muscle injury incited by oxidative or ER stress responses and H₂S might be employed as a potential therapeutic to alleviate the harmful metabolic effects of HHcy conditions. Advisors/Committee Members: Tyagi, Suresh C., Clark, Barbara J., Clark, Barbara J., Maldonado, Claudio, Cole, Marsha, Watson, Corey.

Subjects/Keywords: homocysteine; cellular stress; muscle atrophy; reactive oxygen species; angiogenesis; ER-stress; Nutritional and Metabolic Diseases

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APA (6^th Edition):

Majumder, A. (2018). Effects of hydrogen sulfide in hyperhomocysteinemia-mediated skeletal muscle myopathy. (Doctoral Dissertation). University of Louisville. Retrieved from 10.18297/etd/3114 ; https://ir.library.louisville.edu/etd/3114

Chicago Manual of Style (16^th Edition):

Majumder, Avisek. “Effects of hydrogen sulfide in hyperhomocysteinemia-mediated skeletal muscle myopathy.” 2018. Doctoral Dissertation, University of Louisville. Accessed January 28, 2021. 10.18297/etd/3114 ; https://ir.library.louisville.edu/etd/3114.

MLA Handbook (7^th Edition):

Majumder, Avisek. “Effects of hydrogen sulfide in hyperhomocysteinemia-mediated skeletal muscle myopathy.” 2018. Web. 28 Jan 2021.

Vancouver:

Majumder A. Effects of hydrogen sulfide in hyperhomocysteinemia-mediated skeletal muscle myopathy. [Internet] [Doctoral dissertation]. University of Louisville; 2018. [cited 2021 Jan 28]. Available from: 10.18297/etd/3114 ; https://ir.library.louisville.edu/etd/3114.

Council of Science Editors:

Majumder A. Effects of hydrogen sulfide in hyperhomocysteinemia-mediated skeletal muscle myopathy. [Doctoral Dissertation]. University of Louisville; 2018. Available from: 10.18297/etd/3114 ; https://ir.library.louisville.edu/etd/3114

University of Kentucky

10. Platt, Kristen M. Impact of Positive and Negative Health Behaviors on Female Mice and/or their Offspring.

Degree: 2014, University of Kentucky

URL: https://uknowledge.uky.edu/pharmacol_etds/8

► Obesity is an ever-growing concern in the developed world that carries with it a plethora of health issues. For example, obesity increases an individual’s risk… (more)

Subjects/Keywords: obesity; high fat diet; exercise; branched chain amino acids; pregnancy; Nutritional and Metabolic Diseases

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APA (6^th Edition):

Platt, K. M. (2014). Impact of Positive and Negative Health Behaviors on Female Mice and/or their Offspring. (Doctoral Dissertation). University of Kentucky. Retrieved from https://uknowledge.uky.edu/pharmacol_etds/8

Chicago Manual of Style (16^th Edition):

Platt, Kristen M. “Impact of Positive and Negative Health Behaviors on Female Mice and/or their Offspring.” 2014. Doctoral Dissertation, University of Kentucky. Accessed January 28, 2021. https://uknowledge.uky.edu/pharmacol_etds/8.

MLA Handbook (7^th Edition):

Platt, Kristen M. “Impact of Positive and Negative Health Behaviors on Female Mice and/or their Offspring.” 2014. Web. 28 Jan 2021.

Vancouver:

Platt KM. Impact of Positive and Negative Health Behaviors on Female Mice and/or their Offspring. [Internet] [Doctoral dissertation]. University of Kentucky; 2014. [cited 2021 Jan 28]. Available from: https://uknowledge.uky.edu/pharmacol_etds/8.

Council of Science Editors:

Platt KM. Impact of Positive and Negative Health Behaviors on Female Mice and/or their Offspring. [Doctoral Dissertation]. University of Kentucky; 2014. Available from: https://uknowledge.uky.edu/pharmacol_etds/8

University of Louisville

11. Li, Fengyuan. Dual role of antimicrobial peptide cathelicidin in alcohol-associated liver disease.

Degree: PhD, 2020, University of Louisville

URL: https://ir.library.louisville.edu/etd/3383

► Patients with alcohol-associated liver disease (ALD) have high morbidity and mortality in its severe forms. One of the major features in different forms of… (more)

▼ Patients with alcohol-associated liver disease (ALD) have high morbidity and mortality in its severe forms. One of the major features in different forms of ALD is the altered gut microbiota. Antimicrobial peptides (AMPs) play a crucial role in maintaining gut microbiota homeostasis. LL-37 (known as CRAMP in mouse) is the sole member of the human cathelicidin family and has piqued great research interest for its dual role in modulating microbiota and the immune response in metabolic diseases. Inflammasome activation is an important component of the liver pathophysiology in ALD and requires two signals for its full activation to induce the maturation and release of IL-1β, to induce inflammation. Whether LL-37/CRAMP is involved in the regulation of inflammasome activation in ALD remains unclear. The first aim of this dissertation was to investigate whether CRAMP protects the liver from alcohol-induced injury and whether the effect is mediated through regulation of gut microbiota and inflammasome activation inhibition. Indeed, CRAMP deficiency exacerbated, while exogenous CRAMP peptide alleviated, alcohol-induced liver injury through inhibition of inflammasome activation by decreasing LPS function and uric acid (UA) production. Obese alcoholic subjects have elevated serum ALT levels and are often at high risk of progressing from simple fatty liver to advanced ALD. Increased neutrophil infiltration and chemokine expression were linked to the synergistic effects of alcohol consumption and obesity. LL-37 and CRAMP has been recognized as chemoattractants to neutrophils and inflammatory monocytes through membrane chemokine receptors. The second aim was to investigate the role of CRAMP in binge alcohol-induced liver injury in high fat diet (HFD)-fed mice. CRAMP knockout (Camp^-/-) mice were protected from HFD feeding induced weight gain and adipocyte enlargement, liver injury and steatosis; importantly, Camp^-/- mice had significantly fewer infiltrated neutrophils in the liver and decreased chemokine expression compared to WT mice. High fat diet plus ethanol (HFD+E) treatment significantly increased hepatic protein levels of CRAMP, which co-localized with Ly6G-positive neutrophils. In summary, the dual effects of CRAMP in alcohol-associated liver disease have been explored. CRAMP plays a protective role in binge alcohol-induced liver injury in chronic alcohol-fed mice, through the inhibition of LPS function and UA-induced inflammasome activation. In contrast, CRAMP acts as a chemoattractant for neutrophil infiltration in HFD-fed mice challenged with binge alcohol, exacerbating liver injury. The present study suggested that the role of CRAMP in alcohol-associated liver disease is dependent on the disease status and targeting CRAMP may represent a novel therapeutic strategy for alcohol-associated liver disease. Advisors/Committee Members: Feng, Wenke, McClain, Craig, Gobejishvili, Leila, Matoba, Nobuyuki, Deng, Zhongbin.

Subjects/Keywords: antimicrobial peptide; cathelicidin; alcoholic liver disease; inflammasome activation; neutrophil infiltration; Nutritional and Metabolic Diseases; Toxicology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Li, F. (2020). Dual role of antimicrobial peptide cathelicidin in alcohol-associated liver disease. (Doctoral Dissertation). University of Louisville. Retrieved from https://ir.library.louisville.edu/etd/3383

Chicago Manual of Style (16^th Edition):

Li, Fengyuan. “Dual role of antimicrobial peptide cathelicidin in alcohol-associated liver disease.” 2020. Doctoral Dissertation, University of Louisville. Accessed January 28, 2021. https://ir.library.louisville.edu/etd/3383.

MLA Handbook (7^th Edition):

Li, Fengyuan. “Dual role of antimicrobial peptide cathelicidin in alcohol-associated liver disease.” 2020. Web. 28 Jan 2021.

Vancouver:

Li F. Dual role of antimicrobial peptide cathelicidin in alcohol-associated liver disease. [Internet] [Doctoral dissertation]. University of Louisville; 2020. [cited 2021 Jan 28]. Available from: https://ir.library.louisville.edu/etd/3383.

Council of Science Editors:

Li F. Dual role of antimicrobial peptide cathelicidin in alcohol-associated liver disease. [Doctoral Dissertation]. University of Louisville; 2020. Available from: https://ir.library.louisville.edu/etd/3383

12. Alshatrat, Sabha. Diabetes Status, Predisposing, Enabling, and Oral Health Illness Level Variables as Predictors of Preventive and Emergency Dental Service Use.

Degree: PhD, Health Services Research, 2015, Old Dominion University

URL: 9781339461632 ; https://digitalcommons.odu.edu/healthservices_etds/1

► The purpose of this study was to clarify the relationship between diabetes and dental service use. This study addressed the question of whether individuals… (more)

▼ The purpose of this study was to clarify the relationship between diabetes and dental service use. This study addressed the question of whether individuals with diabetes are more or less likely to utilize dental services, measured in terms of preventive and emergency services during the past year. A cross-sectional study was conducted to assess the contributions of diabetes status to dental service use, relative to the contributions of Andersen and Newman Framework of Health Services Utilization dimensions (predisposing, enabling, and illness variables) in predicting dental service utilization during the past year using a nationally representative sample from a 2001-2002 National Health and Nutrition Examination Survey (NHANES) dataset. A stratified multistage design was used to obtain a representative probability sample. A series of selection criteria was applied to comply with the purpose of the study. The target population of this study was U.S. civilian, non-institutionalized adults, who were 18 years of age or older. A total of 11,039 subjects participated in the 2001-2002 NHANES. Of those, 4,707 were eligible to participate in the study based on the inclusion and exclusion criteria. The appropriate procedures in Statistical Analysis Software (SAS®) were utilized to accommodate the NHANES sampling design and weights. The data analysis using Chi-Square Test reveals that individuals with diabetes (3%) were significantly (p=0.0002) less likely to utilize dental services in the past 12 months compared to individuals without diabetes (67%). Significant predictors in preventive service utilization model were: gender (OR=1.38, 95% CI: 1.16, 1.65), marital status (OR=0.72, 95% CI:0.56,0.91), age (OR=0.63,95% CI:0.45,0.88), education (OR=2.0, 95% CI:1.53,2.63), income (OR=5.21, 95% CI:1.69,15.98), regular source of care (OR=15.8, 95% CI:11.95, 20.91), dental insurance (OR = 1.53, 95% CI:1.15,2.04), self-reported pain (OR=0.75, 95% CI:0.56,0.99), and recommended care based upon oral exam findings (OR=0.30, 95% CI:0.23,0.41). Diabetics were less likely to obtain preventive service use than non-diabetics (OR=0.60, 95% CI: 0.40, 0.92). Significant predictors in emergency service utilization model were: unmarried status (OR=0.72, 95% CI: 0.54, 0.94), age (OR=0.63, 95% CI: 0.44, 0.89), education (OR=1.53, 95% CI: 1.13, 2.06), regular source of care (OR=6.7, 95% CI:4.77, 9.44), dental insurance (OR= 1.9, 95% CI:1.36, 2.65), self-reported painful tooth (OR=2.02, 95% CI:1.60, 2.57), and recommended care based upon oral exam findings (OR=0.72, 95% CI:0.54, 0.97). The results of this study indicate that diabetes status is a significant predictor of not having a preventive dental visit, even after controlling for age, gender, marital status, income, race/ethnicity, and education. This finding is a reason for concern due to the fact that the literature is full of studies showing the effect of diabetes on oral health and the effect of periodontitis on glycemic control among individuals with diabetes. Therefore, a regular dental… Advisors/Committee Members: Deanne Shuman, Hind Baydoun, Susan Daniel.

Subjects/Keywords: Diabetes; Dental service; Nutrition Examination Survey; Oral health; Periodontal disease; Dentistry; Nutritional and Metabolic Diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Alshatrat, S. (2015). Diabetes Status, Predisposing, Enabling, and Oral Health Illness Level Variables as Predictors of Preventive and Emergency Dental Service Use. (Doctoral Dissertation). Old Dominion University. Retrieved from 9781339461632 ; https://digitalcommons.odu.edu/healthservices_etds/1

Chicago Manual of Style (16^th Edition):

Alshatrat, Sabha. “Diabetes Status, Predisposing, Enabling, and Oral Health Illness Level Variables as Predictors of Preventive and Emergency Dental Service Use.” 2015. Doctoral Dissertation, Old Dominion University. Accessed January 28, 2021. 9781339461632 ; https://digitalcommons.odu.edu/healthservices_etds/1.

MLA Handbook (7^th Edition):

Alshatrat, Sabha. “Diabetes Status, Predisposing, Enabling, and Oral Health Illness Level Variables as Predictors of Preventive and Emergency Dental Service Use.” 2015. Web. 28 Jan 2021.

Vancouver:

Alshatrat S. Diabetes Status, Predisposing, Enabling, and Oral Health Illness Level Variables as Predictors of Preventive and Emergency Dental Service Use. [Internet] [Doctoral dissertation]. Old Dominion University; 2015. [cited 2021 Jan 28]. Available from: 9781339461632 ; https://digitalcommons.odu.edu/healthservices_etds/1.

Council of Science Editors:

Alshatrat S. Diabetes Status, Predisposing, Enabling, and Oral Health Illness Level Variables as Predictors of Preventive and Emergency Dental Service Use. [Doctoral Dissertation]. Old Dominion University; 2015. Available from: 9781339461632 ; https://digitalcommons.odu.edu/healthservices_etds/1

13. Nerud, Kimberly. Make a Move: An Intervention to Reduce Childhood Obesity.

Degree: PhD, Graduate Nursing, 2015, South Dakota State University

URL: https://openprairie.sdstate.edu/etd/1789

► Childhood obesity is increasing in prevalence and concern. Many behaviors contributing to obesity are learned in childhood. To reduce obesity and improve health, effective… (more)

▼ Childhood obesity is increasing in prevalence and concern. Many behaviors contributing to obesity are learned in childhood. To reduce obesity and improve health, effective interventions are being sought. This pilot study tested a provider-led intervention for Head Start Parents. The study was guided by the Social Cognitive Theory Model. Specific aims were (a) to compare the experimental intervention to a control group in producing changes on the primary outcomes (knowledge, attitude, and behavior specific to physical activity and healthy eating); and (b) to examine the feasibility of, and participant satisfaction with, “Make a Move,” a family-based childhood obesity intervention. Participants (n = 27) were randomized and placed in the intervention group or the control group. Pre- and post-test measures for both groups were examined at baseline and post-intervention (Parent Curriculum Questionnaire), and the intervention group was evaluated using the post-test measure Make a Move Satisfaction Survey. The Wilcoxon rank-sum test was used. There was a statistically significant difference in scores for knowledge of healthy eating (z = 1.99, p = 0.05), attitude of physical activity (z = 2.71, p < 0.01), and behavior of physical activity (z = 2.03, p = 0.04). Results indicated that there was not a statistically significant difference in scores for knowledge of physical activity (z = 0.44, p = 0.66), attitude of healthy eating (z = 1.14, p = 0.25), or behavior of healthy eating (z = 1.37, p = 0.17). N = 10 participants (77%) completed all four ix intervention sessions. N = 13 participants (100%) reported that they were mostly or very satisfied with the “Make a Move” intervention. This pilot study provided new insights into the relationship of a provider-led intervention with respect to knowledge, attitude, and behavior in healthy eating and physical activity. This new knowledge will help guide realistic approaches to interventions that prevent childhood obesity. Advisors/Committee Members: Nancy Fahrenwald.

Subjects/Keywords: childhood obesity; intervention; Maternal, Child Health and Neonatal Nursing; Nutrition; Nutritional and Metabolic Diseases

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APA (6^th Edition):

Nerud, K. (2015). Make a Move: An Intervention to Reduce Childhood Obesity. (Doctoral Dissertation). South Dakota State University. Retrieved from https://openprairie.sdstate.edu/etd/1789

Chicago Manual of Style (16^th Edition):

Nerud, Kimberly. “Make a Move: An Intervention to Reduce Childhood Obesity.” 2015. Doctoral Dissertation, South Dakota State University. Accessed January 28, 2021. https://openprairie.sdstate.edu/etd/1789.

MLA Handbook (7^th Edition):

Nerud, Kimberly. “Make a Move: An Intervention to Reduce Childhood Obesity.” 2015. Web. 28 Jan 2021.

Vancouver:

Nerud K. Make a Move: An Intervention to Reduce Childhood Obesity. [Internet] [Doctoral dissertation]. South Dakota State University; 2015. [cited 2021 Jan 28]. Available from: https://openprairie.sdstate.edu/etd/1789.

Council of Science Editors:

Nerud K. Make a Move: An Intervention to Reduce Childhood Obesity. [Doctoral Dissertation]. South Dakota State University; 2015. Available from: https://openprairie.sdstate.edu/etd/1789

14. Nishiyama, Sheila Alexandra Belini. Possíveis impactos da cirurgia bariátrica sobre a saúde periodontal de indivíduos obesos. Determinação do perfil microbiológico e imunológico.

Degree: PhD, Microbiologia, 2013, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/42/42132/tde-26062014-141424/ ;

►

O presente trabalho teve por objetivo avaliar a microbiota subgingival pela técnica de Checkerboard e o perfil de citocinas por imunoensaio com princípio sanduíche baseado… (more)

▼

O presente trabalho teve por objetivo avaliar a microbiota subgingival pela técnica de Checkerboard e o perfil de citocinas por imunoensaio com princípio sanduíche baseado na tecnologia fluxometria do fluido gengival e soro em indivíduos não obesos; e em indivíduos com obesidade, antes e após cirurgia bariátrica. Diferenças na microbiota bucal foram observadas entre não obesos e obesos para 19 espécies bacterianas, particularmente E. corrodens que apresentou diferenças significativas em obesos, com consequente redução após a perda de peso. As citocinas IL-1b, IL-6, IL-10, IL-13, IL-17, TNF-a, leptina e adiponectina apresentaram diferenças estatisticamente significantes (p<0,05) quando esses indivíduos foram comparados. Todas as citocinas analisadas no soro diminuíram após a redução de peso, apenas a adiponectina apresentou concentrações significativamente mais elevadas (p<0,05). Assim, a obesidade promove alterações na microbiota subgengival e na resposta imunológica local e sua prevenção ou controle pode favorecer a saúde bucal.

In this study, the aimed to evaluate the subgingival microbiota using Checkerboard technique and the cytokines profile by using immunoassay based on the flowmetry gingival fluid and serum in non-obese and obese individuals, before and after bariatric surgery. Differences were observed in the oral microbiota between nonobese and obese for 19 bacterial species, particularly E. corrodens that showed significant differences in obese, with a consequent reduction after weight loss. The cytokines IL-1b, IL-6, IL-10, IL-13, IL-17, TNF-a, leptin and adiponectin were statistically different (p <0.05) when these individuals were compared. All analyzed cytokines in serum decreased after weight reduction only adiponectin concentrations showed significantly higher (p <0.05). Thus, obesity causes changes in the subgingival microbiota and the local immune response, and prevention and control can promote oral health.

Advisors/Committee Members: Campos, Mario Julio Avila.

Subjects/Keywords: Citocinas; Cytokines; Doenças nutricionais e metabólicas; Doenças periodontais; Inflamação; Inflammation; Nutritional and metabolic diseases; Obesidade; Obesity; Periodontal diseases; Periodontium; Periodonto

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APA (6^th Edition):

Nishiyama, S. A. B. (2013). Possíveis impactos da cirurgia bariátrica sobre a saúde periodontal de indivíduos obesos. Determinação do perfil microbiológico e imunológico. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/42/42132/tde-26062014-141424/ ;

Chicago Manual of Style (16^th Edition):

Nishiyama, Sheila Alexandra Belini. “Possíveis impactos da cirurgia bariátrica sobre a saúde periodontal de indivíduos obesos. Determinação do perfil microbiológico e imunológico.” 2013. Doctoral Dissertation, University of São Paulo. Accessed January 28, 2021. http://www.teses.usp.br/teses/disponiveis/42/42132/tde-26062014-141424/ ;.

MLA Handbook (7^th Edition):

Nishiyama, Sheila Alexandra Belini. “Possíveis impactos da cirurgia bariátrica sobre a saúde periodontal de indivíduos obesos. Determinação do perfil microbiológico e imunológico.” 2013. Web. 28 Jan 2021.

Vancouver:

Nishiyama SAB. Possíveis impactos da cirurgia bariátrica sobre a saúde periodontal de indivíduos obesos. Determinação do perfil microbiológico e imunológico. [Internet] [Doctoral dissertation]. University of São Paulo; 2013. [cited 2021 Jan 28]. Available from: http://www.teses.usp.br/teses/disponiveis/42/42132/tde-26062014-141424/ ;.

Council of Science Editors:

Nishiyama SAB. Possíveis impactos da cirurgia bariátrica sobre a saúde periodontal de indivíduos obesos. Determinação do perfil microbiológico e imunológico. [Doctoral Dissertation]. University of São Paulo; 2013. Available from: http://www.teses.usp.br/teses/disponiveis/42/42132/tde-26062014-141424/ ;

University of Kentucky

15. Ly, Han Gia. ROLE OF PANCREATIC AMYLIN IN ALZHEIMER’S AND BRAIN MICROVASCULAR PATHOLOGIES.

Degree: 2020, University of Kentucky

URL: https://uknowledge.uky.edu/pharmacol_etds/36

► Alzheimer disease (AD) and cerebral vascular disease (CVD) are common causes of impaired cognition and behavior in humans. Epidemiological studies have shown that AD and… (more)

▼ Alzheimer disease (AD) and cerebral vascular disease (CVD) are common causes of impaired cognition and behavior in humans. Epidemiological studies have shown that AD and CVD development and progression associated with metabolic risk factors including type 2 diabetes (T2D). However, the underlying molecular mechanisms remain elusive, which hampers the development of treatment and prevention strategies. Research results from our laboratory and others have shown that amylin, a hormone secreted by the pancreas and involved in glucose homeostasis, induces small-vessel-type pathologies and modulates amyloid composition in both familial (genetically predisposed) and sporadic forms of AD. The results indicate amylin as a potential molecular modifier of the course of Alzheimer’s and brain microvascular pathologies. The present work provides a basis for understanding the role of pancreatic amylin in brain injury and neurologic deficits associated with aging and metabolic dysfunction. First, we used brain tissues from humans with T2D and AD, and a rat model expressing human amylin in the pancreas (the HIP rat), to test the impact of amylin dysregulation on the brain. We found that high blood levels of amylin promoted vascular accumulation of amylin leading to endothelial cell dysfunction and microvascular injury. Amylin-mediated injury of the cerebrovasculature leads to brain white matter disease and neurological dysfunction in HIP rats. Next, we sought to understand the role of amylin in the development of AD pathology and progression of the disease. Using brain tissues from humans with sporadic and familial forms of AD, AD model rats expressing human amylin (ADHIP rats) and AD model rats expressing non-amyloidogenic rat amylin, we found that high blood levels of amylin modulates AD pathology via amylin-Aβ cross-seeding in the grey matter and also contributes to non-AD molecular pathways such as injuries to small blood vessels supplying the white matter. By staining and imaging of brain amylin and Aβ, we showed that amylin accumulated in the brain parenchyma and small blood vessels, and formed mixed plaques with Aβ. Elevated plasma amylin with aging in ADHIP rats was associated with brain microvascular damage and neurological dysfunction. Based on these studies, we inferred that amyloid-forming amylin secreted by the pancreas modulates brain amyloid composition in both sporadic and familial forms of AD, and that pancreatic expression of human amylin in AD model rats accelerates behavioral deficits. Further, we tested effects of lowering peripheral amylin and the suppression of amylin secretion in AD model rats. We found that the amylin-related pathological processes are reduced by pharmacological lowering amylin deposition in brain capillaries and amylin-Aβ cross-seeding. Genetic suppression of amylin in AD model rats reduces amylin-Aβ cross-seeding and neurologic deficits. Our data show evidence for a role of pancreatic amylin in AD and cerebral microvascular pathology and suggest that drugs reducing amylin accumulation in…

Subjects/Keywords: Amylin; Alzheimer disease; cerebrovascular disease; type 2 diabetes; microvascular injury; Nervous System Diseases; Nutritional and Metabolic Diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ly, H. G. (2020). ROLE OF PANCREATIC AMYLIN IN ALZHEIMER’S AND BRAIN MICROVASCULAR PATHOLOGIES. (Doctoral Dissertation). University of Kentucky. Retrieved from https://uknowledge.uky.edu/pharmacol_etds/36

Chicago Manual of Style (16^th Edition):

Ly, Han Gia. “ROLE OF PANCREATIC AMYLIN IN ALZHEIMER’S AND BRAIN MICROVASCULAR PATHOLOGIES.” 2020. Doctoral Dissertation, University of Kentucky. Accessed January 28, 2021. https://uknowledge.uky.edu/pharmacol_etds/36.

MLA Handbook (7^th Edition):

Ly, Han Gia. “ROLE OF PANCREATIC AMYLIN IN ALZHEIMER’S AND BRAIN MICROVASCULAR PATHOLOGIES.” 2020. Web. 28 Jan 2021.

Vancouver:

Ly HG. ROLE OF PANCREATIC AMYLIN IN ALZHEIMER’S AND BRAIN MICROVASCULAR PATHOLOGIES. [Internet] [Doctoral dissertation]. University of Kentucky; 2020. [cited 2021 Jan 28]. Available from: https://uknowledge.uky.edu/pharmacol_etds/36.

Council of Science Editors:

Ly HG. ROLE OF PANCREATIC AMYLIN IN ALZHEIMER’S AND BRAIN MICROVASCULAR PATHOLOGIES. [Doctoral Dissertation]. University of Kentucky; 2020. Available from: https://uknowledge.uky.edu/pharmacol_etds/36

Florida International University

16. Lopez, Johanna. Correlates of Vitamin D Status in Healthy Older Adults Living in Miami-Dade and its Association with Non-Skeletal Outcomes: A Cross-Sectional Study.

Degree: PhD, Dietetics and Nutrition, 2015, Florida International University

URL: https://digitalcommons.fiu.edu/etd/2256 ; 10.25148/etd.FIDC000148 ; FIDC000148

► Examining factors that affect vitamin D status in the fast-growing elderly population of Miami-Dade, Florida, is needed. Vitamin D deficiency in older adults has… (more)

▼ Examining factors that affect vitamin D status in the fast-growing elderly population of Miami-Dade, Florida, is needed. Vitamin D deficiency in older adults has been linked to correlates of disability, including falls and fractures, and cardiovascular disease. The purpose of this study was to determine the proportion of vitamin D insufficient individuals and their relationship with vitamin D insufficiency in older adults (n=97) living in Miami-Dade. We evaluated the association between vitamin D status and 1) dual task physical performance to understand the link between vitamin D and cognition in the context of mobility; and 2) cardiometabolic risk, measured by galvanic skin response, pulse oximetry, and blood pressure to create a composite score based on autonomic nervous system and endothelial function. Participants completed baseline assessments that included serum levels of vitamin D, anthropometrics, body composition, dual task physical performance and cardiometabolic risk. Surveys to evaluate vitamin D intake, sun exposure, physical activity, and depressive symptoms were completed. Spearman’s correlations, independent t-tests, paired t-tests, repeated measures ANOVAs, and multiple logistic and linear regressions were used to examine the relationship of vitamin D insufficiency (25(OH)D /ml) and sufficiency (25(OH)D ≥30 ng/ml) with determinants of vitamin D status, dual task physical performance variables and cardiometabolic risk scores. Although the proportion of vitamin D insufficient individuals was lower when compared to the prevalance of the general United States elderly population, it was still common in healthy community-dwelling older adults living in Miami-Dade County, especially among Hispanics. Factors that affected skin synthesis (ethnicity, and sun exposure), and bioavailability/metabolism (obesity) were significant predictors of vitamin D status. Vitamin D insufficiency was not significantly correlated with worse dual task physical performance; however, cognitive performance was worse in the vitamin D insufficient group. Our results suggest a relationship of vitamin D insufficiency with executive dysfunction, and support an association with cardiometabolic risk using an innovative electro-sensor complex, possibly by modulating autonomic nervous system activity and vascular function, thus affecting cardiac performance. Advisors/Committee Members: Adriana Campa, Fatma G. Huffman, Juan P. Liuzzi, Tan Li, John E. Lewis.

Subjects/Keywords: Vitamin D; elderly; physical performance; cardiometabolic risk; Cardiovascular Diseases; Dietetics and Clinical Nutrition; Nutritional and Metabolic Diseases; Physical Therapy

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APA (6^th Edition):

Lopez, J. (2015). Correlates of Vitamin D Status in Healthy Older Adults Living in Miami-Dade and its Association with Non-Skeletal Outcomes: A Cross-Sectional Study. (Doctoral Dissertation). Florida International University. Retrieved from https://digitalcommons.fiu.edu/etd/2256 ; 10.25148/etd.FIDC000148 ; FIDC000148

Chicago Manual of Style (16^th Edition):

Lopez, Johanna. “Correlates of Vitamin D Status in Healthy Older Adults Living in Miami-Dade and its Association with Non-Skeletal Outcomes: A Cross-Sectional Study.” 2015. Doctoral Dissertation, Florida International University. Accessed January 28, 2021. https://digitalcommons.fiu.edu/etd/2256 ; 10.25148/etd.FIDC000148 ; FIDC000148.

MLA Handbook (7^th Edition):

Lopez, Johanna. “Correlates of Vitamin D Status in Healthy Older Adults Living in Miami-Dade and its Association with Non-Skeletal Outcomes: A Cross-Sectional Study.” 2015. Web. 28 Jan 2021.

Vancouver:

Lopez J. Correlates of Vitamin D Status in Healthy Older Adults Living in Miami-Dade and its Association with Non-Skeletal Outcomes: A Cross-Sectional Study. [Internet] [Doctoral dissertation]. Florida International University; 2015. [cited 2021 Jan 28]. Available from: https://digitalcommons.fiu.edu/etd/2256 ; 10.25148/etd.FIDC000148 ; FIDC000148.

Council of Science Editors:

Lopez J. Correlates of Vitamin D Status in Healthy Older Adults Living in Miami-Dade and its Association with Non-Skeletal Outcomes: A Cross-Sectional Study. [Doctoral Dissertation]. Florida International University; 2015. Available from: https://digitalcommons.fiu.edu/etd/2256 ; 10.25148/etd.FIDC000148 ; FIDC000148

17. Anaya, Elizabeth. Investigations of a Low Carbohydrate Ketogenic Diet as a Possible Treatment for Malignant Brain Tumors.

Degree: Biology, 2020, Regis University

URL: https://epublications.regis.edu/theses/954

► Cancer is now the leading cause of premature death in the U.S. and second worldwide. However, all cancers on average have seen a 20%… (more)

Subjects/Keywords: Alternative and Complementary Medicine; Biochemical Phenomena, Metabolism, and Nutrition; Nervous System Diseases; Nutritional and Metabolic Diseases; Nutrition; Ketogenic Diet; Cancer; Metabolism

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APA (6^th Edition):

Anaya, E. (2020). Investigations of a Low Carbohydrate Ketogenic Diet as a Possible Treatment for Malignant Brain Tumors. (Thesis). Regis University. Retrieved from https://epublications.regis.edu/theses/954

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Anaya, Elizabeth. “Investigations of a Low Carbohydrate Ketogenic Diet as a Possible Treatment for Malignant Brain Tumors.” 2020. Thesis, Regis University. Accessed January 28, 2021. https://epublications.regis.edu/theses/954.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Anaya, Elizabeth. “Investigations of a Low Carbohydrate Ketogenic Diet as a Possible Treatment for Malignant Brain Tumors.” 2020. Web. 28 Jan 2021.

Vancouver:

Anaya E. Investigations of a Low Carbohydrate Ketogenic Diet as a Possible Treatment for Malignant Brain Tumors. [Internet] [Thesis]. Regis University; 2020. [cited 2021 Jan 28]. Available from: https://epublications.regis.edu/theses/954.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Anaya E. Investigations of a Low Carbohydrate Ketogenic Diet as a Possible Treatment for Malignant Brain Tumors. [Thesis]. Regis University; 2020. Available from: https://epublications.regis.edu/theses/954

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Kentucky

18. Wu, Congqing. THE ROLE OF ANGIOTENSINOGEN IN ATHEROSCLEROSIS AND OBESITY.

Degree: 2014, University of Kentucky

URL: https://uknowledge.uky.edu/nutrisci_etds/16

► Angiotensinogen is the only known precursor in the renin-angiotensin system, a hormonal system best known as an essential regulator of blood pressure and fluid homeostasis.… (more)

▼ Angiotensinogen is the only known precursor in the renin-angiotensin system, a hormonal system best known as an essential regulator of blood pressure and fluid homeostasis. Angiotensinogen is sequentially cleaved by renin and angiotensin- converting enzyme to generate angiotensin II. As the major effector peptide, angiotensin II mainly function through angiotensin type 1 receptor. Angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and more recently renin inhibitors are widely known as the 3 classic renin-angiotensin system inhibitory drugs against hypertension and atherosclerosis. Here, we developed an array of regents to explore the effects of angiotensinogen inhibition. First, we demonstrated that genetic deficiency of angiotensinogen not only protected against hypercholesterolemia- induced atherosclerosis but also prevented diet-induced obesity. Then we found weekly intraperitoneal injection of antisense oligonucleotides against angiotensinogen remarkably surpressed body weight gain in mice fed a western diet, which was absent from classic renin-angiotensin system inhibition. The suppressed body weight gain was attributable to diminished body fat mass gain and enhanced energy expenditure. More excitingly, angiotensinogen antisense oligonucleotides regressed body weight gain on obese mice. Together, our findings revealed a unique feature of angiotensinogen inhibition beyond classic renin angiotensin inhibition and demonstrated therapeutic potentials of angiotensinogen antisense oligonucleotides against hypertension, atherosclerosis, and obesity. We also developed an in vivo system to explore the functional consequences of disrupting a conserved Cys18-Cys137 disulfide bridge in angiotensinogen. The formation of this disulfide bridge could trigger conformational changes in angiotensinogen, thereby facilitating renin cleavage of angiotensinogen. It was predicted that the redox-sensitive disulfide bridge might change the efficiency of angiotensinogen/renin reaction to release angiotensin II, thus modulate angiotensin II-dependent functions. We determined effects of the presence and absence of the disulfide bridge on angiotensin II concentrations and responses in mice expressing either native angiotensinogen or Cys18Ser, Cys137Ser mutated angiotensinogen in liver via adeno-associated viral vectors. Contrary to the prediction, disruption of Cys18-Cys137 disulfide bridge in angiotensinogen had no discernible effects on angiotensin II production and angiotensin II-dependent functions in mice.

Subjects/Keywords: angiotensinogen; atherosclerosis; obesity; disulfide bond; Biochemistry; Biology; Cardiovascular Diseases; Disease Modeling; Molecular Genetics; Nutritional and Metabolic Diseases; Other Genetics and Genomics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wu, C. (2014). THE ROLE OF ANGIOTENSINOGEN IN ATHEROSCLEROSIS AND OBESITY. (Doctoral Dissertation). University of Kentucky. Retrieved from https://uknowledge.uky.edu/nutrisci_etds/16

Chicago Manual of Style (16^th Edition):

Wu, Congqing. “THE ROLE OF ANGIOTENSINOGEN IN ATHEROSCLEROSIS AND OBESITY.” 2014. Doctoral Dissertation, University of Kentucky. Accessed January 28, 2021. https://uknowledge.uky.edu/nutrisci_etds/16.

MLA Handbook (7^th Edition):

Wu, Congqing. “THE ROLE OF ANGIOTENSINOGEN IN ATHEROSCLEROSIS AND OBESITY.” 2014. Web. 28 Jan 2021.

Vancouver:

Wu C. THE ROLE OF ANGIOTENSINOGEN IN ATHEROSCLEROSIS AND OBESITY. [Internet] [Doctoral dissertation]. University of Kentucky; 2014. [cited 2021 Jan 28]. Available from: https://uknowledge.uky.edu/nutrisci_etds/16.

Council of Science Editors:

Wu C. THE ROLE OF ANGIOTENSINOGEN IN ATHEROSCLEROSIS AND OBESITY. [Doctoral Dissertation]. University of Kentucky; 2014. Available from: https://uknowledge.uky.edu/nutrisci_etds/16

University of Kentucky

19. Hilgendorf, Madison. ASSESSING MALNUTRITION IN LIVER DISEASE PATIENTS BEING EVALUATED FOR TRANSPLANT USING THE NUTRITION FOCUSED PHYSICAL EXAM.

Degree: 2018, University of Kentucky

URL: https://uknowledge.uky.edu/foodsci_etds/61

► Patients with liver disease have an increased risk for malnutrition because of side effects of the disease. The Nutrition Focused Physical Exam (NFPE) was developed… (more)

Subjects/Keywords: Cirrhosis; Malnutrition; Nutrition Focused Physical Exam; Transplant; PG-SGA; Dietetics and Clinical Nutrition; Digestive System Diseases; Nutritional and Metabolic Diseases

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APA (6^th Edition):

Hilgendorf, M. (2018). ASSESSING MALNUTRITION IN LIVER DISEASE PATIENTS BEING EVALUATED FOR TRANSPLANT USING THE NUTRITION FOCUSED PHYSICAL EXAM. (Masters Thesis). University of Kentucky. Retrieved from https://uknowledge.uky.edu/foodsci_etds/61

Chicago Manual of Style (16^th Edition):

Hilgendorf, Madison. “ASSESSING MALNUTRITION IN LIVER DISEASE PATIENTS BEING EVALUATED FOR TRANSPLANT USING THE NUTRITION FOCUSED PHYSICAL EXAM.” 2018. Masters Thesis, University of Kentucky. Accessed January 28, 2021. https://uknowledge.uky.edu/foodsci_etds/61.

MLA Handbook (7^th Edition):

Hilgendorf, Madison. “ASSESSING MALNUTRITION IN LIVER DISEASE PATIENTS BEING EVALUATED FOR TRANSPLANT USING THE NUTRITION FOCUSED PHYSICAL EXAM.” 2018. Web. 28 Jan 2021.

Vancouver:

Hilgendorf M. ASSESSING MALNUTRITION IN LIVER DISEASE PATIENTS BEING EVALUATED FOR TRANSPLANT USING THE NUTRITION FOCUSED PHYSICAL EXAM. [Internet] [Masters thesis]. University of Kentucky; 2018. [cited 2021 Jan 28]. Available from: https://uknowledge.uky.edu/foodsci_etds/61.

Council of Science Editors:

Hilgendorf M. ASSESSING MALNUTRITION IN LIVER DISEASE PATIENTS BEING EVALUATED FOR TRANSPLANT USING THE NUTRITION FOCUSED PHYSICAL EXAM. [Masters Thesis]. University of Kentucky; 2018. Available from: https://uknowledge.uky.edu/foodsci_etds/61

20. Matevossian, Anouch. Endothelial Driven Inflammation in Metabolic Disease: A Dissertation.

Degree: PhD, Program in Molecular Medicine, 2015, U of Massachusetts : Med

URL: https://escholarship.umassmed.edu/gsbs_diss/757

► Obesity has been on the rise over the last 30 years, reaching worldwide epidemic proportions. Obesity has been linked to multiple metabolic disorders and… (more)

▼ Obesity has been on the rise over the last 30 years, reaching worldwide epidemic proportions. Obesity has been linked to multiple metabolic disorders and co-morbidities such as Type 2 Diabetes Mellitus (T2DM), cardiovascular disease, non-alcoholic steatohepatitis and various cancers. Furthermore, obesity is associated with a chronic state of low-grade inflammation in adipose tissue (AT), and it is thought that insulin resistance (IR) and T2DM is associated with the inflammatory state of AT. Endothelial cells (ECs) mediate the migration of immune cells into underlying tissues during times of inflammation, including obesity- and cardiovascular disease-associated inflammation. Cytokines and chemoattractants released from inflamed tissues promote EC activation. Upon activation, ECs increase the expression of leukocyte adhesion molecules (LCAMs) including intercellular adhesion molecule 1 (ICAM-1), vascular adhesion molecule 1 (VCAM-1), E-selectin (E-sel) and P-selectin (P-sel). Increased expression of these LCAMs and increased infiltration of inflammatory cells such as macrophages, have been linked to IR, diabetes and atherosclerosis in obese individuals. Preliminary data from our lab suggests that lipolysis induced by the β-adrenergic receptor agonist CL 316,243 causes an increase in endothelial LCAM gene expression. In addition, histological analyses show increased content of immune cells within AT after the ECs become activated. Here, we demonstrate that CL 316,243-induced lipolysis causes infiltration of neutrophils in wild type (WT) but not E-sel knockout (KO) mice. Following EC activation, there was also a marked increase in cytokine gene expression including IL-1β, MCP-1, and TNF-α in an E-sel-dependent manner. In contrast, fasting-induced lipolysis was associated with increased macrophage infiltration into AT in the absence of EC activation in an E-sel-independent manner. We also examined the role of mitogen activated protein kinase kinase kinase kinase 4 (MAP4K4) as a potential contributor to endothelial activation and atherosclerosis. Here we demonstrate that deletion of MAP4K4 in ECs in vitro diminishes TNF-α-induced EC activation. Additionally, MAP4K4 depletion in primary ECs derived from lungs of mice expressing MAP4K4 shRNA decreases EC activation. Finally, endothelial specific depletion or loss of MAP4K4 reduced atherosclerotic plaque formation in vivo. Taken together, these results highlight the importance of the endothelium in modulating obesity-associated comorbidities. Furthermore, these data implicate endothelial MAP4K4 as a novel regulator of EC activation and consequently AT inflammation and atherosclerosis. Advisors/Committee Members: Michael P. Czech, PhD.

Subjects/Keywords: Endothelial Cells; Inflammation; Metabolic Diseases; Protein-Serine-Threonine Kinases; Endothelium; Obesity; Comorbidity; Cellular and Molecular Physiology; Endocrinology; Endocrinology, Diabetes, and Metabolism; Molecular Genetics; Nutritional and Metabolic Diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Matevossian, A. (2015). Endothelial Driven Inflammation in Metabolic Disease: A Dissertation. (Doctoral Dissertation). U of Massachusetts : Med. Retrieved from https://escholarship.umassmed.edu/gsbs_diss/757

Chicago Manual of Style (16^th Edition):

Matevossian, Anouch. “Endothelial Driven Inflammation in Metabolic Disease: A Dissertation.” 2015. Doctoral Dissertation, U of Massachusetts : Med. Accessed January 28, 2021. https://escholarship.umassmed.edu/gsbs_diss/757.

MLA Handbook (7^th Edition):

Matevossian, Anouch. “Endothelial Driven Inflammation in Metabolic Disease: A Dissertation.” 2015. Web. 28 Jan 2021.

Vancouver:

Matevossian A. Endothelial Driven Inflammation in Metabolic Disease: A Dissertation. [Internet] [Doctoral dissertation]. U of Massachusetts : Med; 2015. [cited 2021 Jan 28]. Available from: https://escholarship.umassmed.edu/gsbs_diss/757.

Council of Science Editors:

Matevossian A. Endothelial Driven Inflammation in Metabolic Disease: A Dissertation. [Doctoral Dissertation]. U of Massachusetts : Med; 2015. Available from: https://escholarship.umassmed.edu/gsbs_diss/757

University of Western Ontario

21. Peters, Kia Mae. Effects of Niacin and Vitamin D on Endothelial Cell Angiogenic Function and Vascular Regeneration During Lipotoxicity.

Degree: 2019, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/6251

► Observational studies have suggested an association between low levels of niacin and vitamin D and increased cardiovascular disease risk. Both vitamins have been shown to… (more)

Subjects/Keywords: Metabolic syndrome; TCAM; lipotoxicity; peripheral vascular disease; 1; 25-dihydroxyvitamin D3; hind limb ischemia; Alternative and Complementary Medicine; Cardiovascular Diseases; Nutritional and Metabolic Diseases

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APA (6^th Edition):

Peters, K. M. (2019). Effects of Niacin and Vitamin D on Endothelial Cell Angiogenic Function and Vascular Regeneration During Lipotoxicity. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/6251

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Peters, Kia Mae. “Effects of Niacin and Vitamin D on Endothelial Cell Angiogenic Function and Vascular Regeneration During Lipotoxicity.” 2019. Thesis, University of Western Ontario. Accessed January 28, 2021. https://ir.lib.uwo.ca/etd/6251.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Peters, Kia Mae. “Effects of Niacin and Vitamin D on Endothelial Cell Angiogenic Function and Vascular Regeneration During Lipotoxicity.” 2019. Web. 28 Jan 2021.

Vancouver:

Peters KM. Effects of Niacin and Vitamin D on Endothelial Cell Angiogenic Function and Vascular Regeneration During Lipotoxicity. [Internet] [Thesis]. University of Western Ontario; 2019. [cited 2021 Jan 28]. Available from: https://ir.lib.uwo.ca/etd/6251.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Peters KM. Effects of Niacin and Vitamin D on Endothelial Cell Angiogenic Function and Vascular Regeneration During Lipotoxicity. [Thesis]. University of Western Ontario; 2019. Available from: https://ir.lib.uwo.ca/etd/6251

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. Amano, Shinya U. Local Macrophage Proliferation in Adipose Tissue Is a Characteristic of Obesity-Associated Inflammation: A Dissertation.

Degree: PhD, Program in Molecular Medicine, 2013, U of Massachusetts : Med

URL: http://escholarship.umassmed.edu/gsbs_diss/652

► Obesity and diabetes are major public health problems facing the world today. Extending our understanding of adipose tissue biology, and how it changes in… (more)

▼ Obesity and diabetes are major public health problems facing the world today. Extending our understanding of adipose tissue biology, and how it changes in obesity, will hopefully better equip our society in dealing with the obesity epidemic. Macrophages and other immune cells accumulate in the adipose tissue in obesity and secrete cytokines that can promote insulin resistance. Adipose tissue macrophages (ATMs) are thought to originate from bone marrow-derived monocytes, which infiltrate the tissue from the circulation. Much work has been done to demonstrate that inhibition of monocyte recruitment to the adipose tissue can ameliorate insulin resistance. While monocytes can enter the adipose tissue, we have shown here that local macrophage proliferation may be the predominant mechanism by which macrophages self-renew in the adipose tissue. We demonstrated that two cell proliferation markers, Ki67 and EdU, can be readily detected in macrophages isolated from adipose tissue of both lean and obese mice. These analyses revealed that 2-4% of ATMs in lean and 10-20% of ATMs in obese mice express the proliferation marker Ki67. Importantly, Ki67+ macrophages were identified within the adipose tissue in crown-like structures. Similarly, a 3-hour in vivo pulse with the thymidine analog EdU showed that nearly 5% of macrophages in epididymal adipose tissue of ob/ob mice were in the S-phase of cell division. Interestingly, obesity increased the rate of macrophage proliferation in adipose tissue but did not affect macrophage proliferation in other tissues. We also used clodronate liposomes to deplete circulating monocytes in obese mice. Surprisingly, monocyte depletion for a total of at least 80 hours did not cause a decrease in ATM content in adipose tissue. Prolonged exposure of mice to EdU in drinking water revealed that approximately half of the ATMs in the epididymal fat pads of ob/ob mice had proliferated locally within 80 hours. Amazingly, these rates were the same with or without monocyte depletion, meaning that the proliferating cells were not freshly recruited monocytes. Overall, these results suggest that local proliferation unexpectedly makes a major contribution to maintaining the large population of macrophages present in the obese adipose tissue in the steady state. This suggests that increased rates of local macrophage proliferation may also be partly responsible for the massive increase in ATM content that occurs in obesity. This information could have implications for future therapeutic strategies in the management of diabetes. Advisors/Committee Members: Michael Czech, PhD.

Subjects/Keywords: Adipose Tissue; Macrophages; Obesity; Inflammation; Diabetes Mellitus; Insulin Resistance; Cellular and Molecular Physiology; Endocrinology; Nutritional and Metabolic Diseases; Physiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Amano, S. U. (2013). Local Macrophage Proliferation in Adipose Tissue Is a Characteristic of Obesity-Associated Inflammation: A Dissertation. (Doctoral Dissertation). U of Massachusetts : Med. Retrieved from http://escholarship.umassmed.edu/gsbs_diss/652

Chicago Manual of Style (16^th Edition):

Amano, Shinya U. “Local Macrophage Proliferation in Adipose Tissue Is a Characteristic of Obesity-Associated Inflammation: A Dissertation.” 2013. Doctoral Dissertation, U of Massachusetts : Med. Accessed January 28, 2021. http://escholarship.umassmed.edu/gsbs_diss/652.

MLA Handbook (7^th Edition):

Amano, Shinya U. “Local Macrophage Proliferation in Adipose Tissue Is a Characteristic of Obesity-Associated Inflammation: A Dissertation.” 2013. Web. 28 Jan 2021.

Vancouver:

Amano SU. Local Macrophage Proliferation in Adipose Tissue Is a Characteristic of Obesity-Associated Inflammation: A Dissertation. [Internet] [Doctoral dissertation]. U of Massachusetts : Med; 2013. [cited 2021 Jan 28]. Available from: http://escholarship.umassmed.edu/gsbs_diss/652.

Council of Science Editors:

Amano SU. Local Macrophage Proliferation in Adipose Tissue Is a Characteristic of Obesity-Associated Inflammation: A Dissertation. [Doctoral Dissertation]. U of Massachusetts : Med; 2013. Available from: http://escholarship.umassmed.edu/gsbs_diss/652

University of Louisville

23. Clair, Heather Brooke. PCB-associated steatohepatitis and the role of nuclear receptors.

Degree: PhD, 2017, University of Louisville

URL: 10.18297/etd/2867 ; https://ir.library.louisville.edu/etd/2867

► Metabolic diseases, including fatty liver disease, hyperglycemia, and obesity, result when body systems responsible for managing allostasis (dynamic homeostasis across systems) are pressured beyond… (more)

Subjects/Keywords: steatohepatitis; polychlorinated biphenyls; metabolism-disrupting chemicals; Anniston, Alabama; non-alcoholic fatty liver disease; Nutritional and Metabolic Diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Clair, H. B. (2017). PCB-associated steatohepatitis and the role of nuclear receptors. (Doctoral Dissertation). University of Louisville. Retrieved from 10.18297/etd/2867 ; https://ir.library.louisville.edu/etd/2867

Chicago Manual of Style (16^th Edition):

Clair, Heather Brooke. “PCB-associated steatohepatitis and the role of nuclear receptors.” 2017. Doctoral Dissertation, University of Louisville. Accessed January 28, 2021. 10.18297/etd/2867 ; https://ir.library.louisville.edu/etd/2867.

MLA Handbook (7^th Edition):

Clair, Heather Brooke. “PCB-associated steatohepatitis and the role of nuclear receptors.” 2017. Web. 28 Jan 2021.

Vancouver:

Clair HB. PCB-associated steatohepatitis and the role of nuclear receptors. [Internet] [Doctoral dissertation]. University of Louisville; 2017. [cited 2021 Jan 28]. Available from: 10.18297/etd/2867 ; https://ir.library.louisville.edu/etd/2867.

Council of Science Editors:

Clair HB. PCB-associated steatohepatitis and the role of nuclear receptors. [Doctoral Dissertation]. University of Louisville; 2017. Available from: 10.18297/etd/2867 ; https://ir.library.louisville.edu/etd/2867

24. Tran, Khanh-Van T. Origin of White and Brown Adipose Cells From Vascular Endothelium: A Dissertation.

Degree: PhD, Program in Molecular Medicine, 2012, U of Massachusetts : Med

URL: https://escholarship.umassmed.edu/gsbs_diss/591

► Obesity is associated with insulin resistance, dyslipidemia, and cardiovascular disease. The current obesity epidemic is the result of surplus energy consumption. Excess energy is… (more)

▼ Obesity is associated with insulin resistance, dyslipidemia, and cardiovascular disease. The current obesity epidemic is the result of surplus energy consumption. Excess energy is stored in expanding adipose tissue. Adipose tissue growth entails the enlargement of existing adipocytes, the formation of new fat cells from preexisting progenitors, and the coordinated development of supporting vasculature. Identifying adipocyte progenitors and the mechanism of adipose tissue expansion is crucial for the development of new strategies to combat obesity and its complications. Though important progress has been made towards understanding the developmental origin of adipocytes, the identities of adipocyte progenitors are still not completely known. The main objective of this study is to determine whether endothelial cells of the adipose tissue can give rise to new adipocytes. Our results indicate that murine endothelial cells of adipose tissue are pluripotent and can potentially give rise to preadipocytes. Lineage tracing experiments using the VE-Cadherin-Cre transgenic mouse reveal localization of reporter genes in endothelial cells, preadipocytes and white and brown adipocytes. Moreover, capillary sprouts from human adipose tissue, which have predominantly endothelial cell characteristics, are found to express Zfp423, a preadipocyte determination factor. In response to PPARγ activation, endothelial characteristics of sprouting cells are progressively lost, and cells form structurally and biochemically defined adipocytes. Taken together, our data support an endothelial origin of a population of adipocytes. The ability of the vascular endothelium to give rise to adipocytes may explain how angiogenesis and adipogenesis can be temporally and spatially coordinated. Analysis of BAT and WAT revealed that adipose depots have distinct compositions of adipocyte progenitors. Of the CD45-CD29+Sca1+CD24+ progenitor population, only 17% and 52% express VE-Cadherin in WAT and BAT, respectively. Our data show that the number of these specific progenitors in BAT and WAT are highly variable and suggest that a considerable number of adipocytes progenitors may have a non-endothelial cell origin. Differences in composition and types of adipocyte progenitors may explain the differences in the adipocytes phenotypes that we observe in discrete depots. In brief, we find that the vascular endothelium gives rise to a population of brown and white fat cells, and that the number of endothelial-derived adipocyte progenitors residing in BAT and WAT is highly variable. These results expand our current understanding of adipose tissue growth, and, we hope, will accelerate the development of treatments for obesity-related complications. Advisors/Committee Members: Silvia Corvera, M.D..

Subjects/Keywords: Adipocytes; Adipose Tissue; Endothelial Cells; Cell and Developmental Biology; Cells; Nutritional and Metabolic Diseases; Pathological Conditions, Signs and Symptoms; Therapeutics; Tissues

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tran, K. T. (2012). Origin of White and Brown Adipose Cells From Vascular Endothelium: A Dissertation. (Doctoral Dissertation). U of Massachusetts : Med. Retrieved from https://escholarship.umassmed.edu/gsbs_diss/591

Chicago Manual of Style (16^th Edition):

Tran, Khanh-Van T. “Origin of White and Brown Adipose Cells From Vascular Endothelium: A Dissertation.” 2012. Doctoral Dissertation, U of Massachusetts : Med. Accessed January 28, 2021. https://escholarship.umassmed.edu/gsbs_diss/591.

MLA Handbook (7^th Edition):

Tran, Khanh-Van T. “Origin of White and Brown Adipose Cells From Vascular Endothelium: A Dissertation.” 2012. Web. 28 Jan 2021.

Vancouver:

Tran KT. Origin of White and Brown Adipose Cells From Vascular Endothelium: A Dissertation. [Internet] [Doctoral dissertation]. U of Massachusetts : Med; 2012. [cited 2021 Jan 28]. Available from: https://escholarship.umassmed.edu/gsbs_diss/591.

Council of Science Editors:

Tran KT. Origin of White and Brown Adipose Cells From Vascular Endothelium: A Dissertation. [Doctoral Dissertation]. U of Massachusetts : Med; 2012. Available from: https://escholarship.umassmed.edu/gsbs_diss/591

Florida International University

25. Bullard-Roberts, Angelle L. Medicinal Plants of Trinidad and Tobago: Selection of Antidiabetic Remedies.

Degree: PhD, Biology, 2016, Florida International University

URL: https://digitalcommons.fiu.edu/etd/2546 ; 10.25148/etd.FIDC000775 ; FIDC000775

► Diabetes mellitus (DM) is a group of non-infectious diseases that cause hyperglycemia. DM symptoms were first clinically described by ancient Greek physicians whose prescriptions… (more)

▼ Diabetes mellitus (DM) is a group of non-infectious diseases that cause hyperglycemia. DM symptoms were first clinically described by ancient Greek physicians whose prescriptions included plant-based remedies. Today, DM affects >400 million people globally and prevalence rates are rapidly increasing in developing countries where basic healthcare relies on local knowledge of botanical remedies. Many developing countries are home to diverse peoples and plants—providing fodder for varied plant-selection strategies and unique botanical pharmacopoeias. I addressed the plant-selection strategies used in a multi-ethnic, developing country, Trinidad and Tobago (T&T), to ascertain their role in shaping the local antidiabetic pharmacopoeia and to assess their benefits and risks in identifying safe and useful remedies. Using literature reviews, field surveys, and laboratory bioassays, I completed three categories of analysis. Ethnobotanical analyses showed that T&T’s antidiabetic pharmacopoeia is primarily of recent origin as >50% of the 48 historical DM remedies were Neotropical natives, including congenerics of well-known medicinal Paleotropical genera. Nevertheless, conservative knowledge transmission was also evident as several Paleotropical species of T&T’s pharmacopoeia, including Momordica charantia and Catharanthus roseus were also used in Africa, India and across the Caribbean. Paleotropical natives with a long history of use are likely to be safer remedies. Ethno-medicinal analyses of the pre- and post-2000 DM remedies of T&T, totaling 99 species, suggest that the centuries-old hot/cold folk disease-model was the model predominantly used in plant-selection. Parallels found between T&T folk concepts and biomedical mechanisms of DM provide probable bases for efficacy but the chronic use of purgatives and bitter-tasting plants is likely to be risky. Phytochemical analyses revealed that 69% of the tested plant extracts contained phenolic compounds, with more than half producing >80% alpha-glucosidase inhibition. Phenolic content and alpha-glucosidase inhibition were strongly correlated among food plants used as medicines, suggesting higher probability of selection as a result of non-target effects. The medicinal use of food plants may provide the best margins of safety and efficacy in identifying antidiabetic remedies. Together, these analyses showed how culture-specific plant-selection strategies can identify safe, useful remedies for developing countries to address their increasing DM prevalence in a cost-effective and sustainable manner. Advisors/Committee Members: Bradley C. Bennett, Suzanne Koptur, Jennifer Richards, J. Martin Quirke, Maria Fadiman.

Subjects/Keywords: Ethnobotany; medicinal plants; diabetes; social network analysis; phenolic; alpha-glucosidase; Ethnomedicine; Alternative and Complementary Medicine; Biology; Botany; Nutritional and Metabolic Diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bullard-Roberts, A. L. (2016). Medicinal Plants of Trinidad and Tobago: Selection of Antidiabetic Remedies. (Doctoral Dissertation). Florida International University. Retrieved from https://digitalcommons.fiu.edu/etd/2546 ; 10.25148/etd.FIDC000775 ; FIDC000775

Chicago Manual of Style (16^th Edition):

Bullard-Roberts, Angelle L. “Medicinal Plants of Trinidad and Tobago: Selection of Antidiabetic Remedies.” 2016. Doctoral Dissertation, Florida International University. Accessed January 28, 2021. https://digitalcommons.fiu.edu/etd/2546 ; 10.25148/etd.FIDC000775 ; FIDC000775.

MLA Handbook (7^th Edition):

Bullard-Roberts, Angelle L. “Medicinal Plants of Trinidad and Tobago: Selection of Antidiabetic Remedies.” 2016. Web. 28 Jan 2021.

Vancouver:

Bullard-Roberts AL. Medicinal Plants of Trinidad and Tobago: Selection of Antidiabetic Remedies. [Internet] [Doctoral dissertation]. Florida International University; 2016. [cited 2021 Jan 28]. Available from: https://digitalcommons.fiu.edu/etd/2546 ; 10.25148/etd.FIDC000775 ; FIDC000775.

Council of Science Editors:

Bullard-Roberts AL. Medicinal Plants of Trinidad and Tobago: Selection of Antidiabetic Remedies. [Doctoral Dissertation]. Florida International University; 2016. Available from: https://digitalcommons.fiu.edu/etd/2546 ; 10.25148/etd.FIDC000775 ; FIDC000775

University of Western Ontario

26. Radford, Bethany N. Metabolic and Expression Changes Associated with a Mouse Model of Intrauterine Growth Restriction (IUGR).

Degree: 2018, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/6023

► Intrauterine growth restriction (IUGR) is a pregnancy condition where fetal growth is suboptimal, resulting in an infant born small for gestational age (<10th percentile) and… (more)

▼ Intrauterine growth restriction (IUGR) is a pregnancy condition where fetal growth is suboptimal, resulting in an infant born small for gestational age (<10th percentile) and is associated with metabolic disorders such as type 2 diabetes in adulthood. This study aims to understand tissue-specific adaptations to fetal undernutrition which predispose the individual to metabolic disorders in adulthood. A model of growth restriction in mice was established using 70% of maternal ad libitum total food (g) (E6.5-birth). At weaning, male offspring received standard chow or a HFHS diet. Body weight and random blood glucose levels were measured at 6 months. To assess metabolism at 6 or 7 months, glucose tolerance, pyruvate challenge and hepatic portal vein insulin challenge tests were administered and serum peptide markers for obesity and diabetes were measured. Metabolic cages were also used at 2 and 7 months to measure activity, food intake and respiratory exchange ratios (RERs). Adult liver, adipose and skeletal muscle and fetal liver was collected for RNA sequencing. Maternal nutrient restricted (MNR) offspring were growth restricted with disproportionately smaller fetal livers. 19% of standard chow-fed MNR offspring became glucose intolerant. On an isocaloric high-fat high-sugar diet no differences in MNR growth or glucose metabolism were detected. However, RERs were reduced at all timepoints in MNR on a HFHS relative to MNR on standard chow. Differences in transcription of genes involved in hypoxia signalling were detected and HIF-2a and HIF-3a proteins were increased in fetal liver of MNR offspring. Genes differentially expressed in the fetus were not differentially expressed at 6 months. Gene expression of metabolically regulatory transcripts in liver, adipose and skeletal muscle did not differ in all MNR and glucose intolerant MNR relative to controls. This model results in a susceptible and non-susceptible population of maternal nutrient restricted offspring and supports the concept of hypoxia signalling contributing to fetal adaptations. Understanding adaptations in hepatic hypoxia signalling in response to fetal undernutrition and how they vary in susceptible and unsusceptible populations will provide insight into how fetal nutrition can influence adult metabolism.

Subjects/Keywords: Growth restriction; glucose tolerance; gene expression; hypoxia; HIF-2a; maternal nutrient restriction; Disease Modeling; Medical Molecular Biology; Nutritional and Metabolic Diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Radford, B. N. (2018). Metabolic and Expression Changes Associated with a Mouse Model of Intrauterine Growth Restriction (IUGR). (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/6023

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Radford, Bethany N. “Metabolic and Expression Changes Associated with a Mouse Model of Intrauterine Growth Restriction (IUGR).” 2018. Thesis, University of Western Ontario. Accessed January 28, 2021. https://ir.lib.uwo.ca/etd/6023.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Radford, Bethany N. “Metabolic and Expression Changes Associated with a Mouse Model of Intrauterine Growth Restriction (IUGR).” 2018. Web. 28 Jan 2021.

Vancouver:

Radford BN. Metabolic and Expression Changes Associated with a Mouse Model of Intrauterine Growth Restriction (IUGR). [Internet] [Thesis]. University of Western Ontario; 2018. [cited 2021 Jan 28]. Available from: https://ir.lib.uwo.ca/etd/6023.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Radford BN. Metabolic and Expression Changes Associated with a Mouse Model of Intrauterine Growth Restriction (IUGR). [Thesis]. University of Western Ontario; 2018. Available from: https://ir.lib.uwo.ca/etd/6023

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Western Ontario

27. Lee, Vanessa R. Panx1 and Panx3 regulate adipocyte development and fat accumulation in vivo.

Degree: 2016, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/3912

► The obesity epidemic is a growing concern due to its various comorbidities and associated risk factors. Pannexins 1 and 3 (Panx1 and Panx3), are members… (more)

Subjects/Keywords: Pannexins; Panx1; Panx3; obesity; adipose-derived stromal cells; adiopogenesis; Cell Biology; Developmental Biology; Nutritional and Metabolic Diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lee, V. R. (2016). Panx1 and Panx3 regulate adipocyte development and fat accumulation in vivo. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/3912

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lee, Vanessa R. “Panx1 and Panx3 regulate adipocyte development and fat accumulation in vivo.” 2016. Thesis, University of Western Ontario. Accessed January 28, 2021. https://ir.lib.uwo.ca/etd/3912.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lee, Vanessa R. “Panx1 and Panx3 regulate adipocyte development and fat accumulation in vivo.” 2016. Web. 28 Jan 2021.

Vancouver:

Lee VR. Panx1 and Panx3 regulate adipocyte development and fat accumulation in vivo. [Internet] [Thesis]. University of Western Ontario; 2016. [cited 2021 Jan 28]. Available from: https://ir.lib.uwo.ca/etd/3912.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lee VR. Panx1 and Panx3 regulate adipocyte development and fat accumulation in vivo. [Thesis]. University of Western Ontario; 2016. Available from: https://ir.lib.uwo.ca/etd/3912

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

East Tennessee State University

28. Ozodiegwu, Ifeoma. The Prevalence and Context of Adult Female Overweight and Obesity in Sub-Saharan Africa.

Degree: DrPH (Doctor of Public Health), Public Health, 2019, East Tennessee State University

URL: https://dc.etsu.edu/etd/3566

► Adult women bear a disproportionate burden of overweight and obesity in Sub-Saharan Africa (SSA). Precise information to understand disease distribution and assess determinants is… (more)

▼ Adult women bear a disproportionate burden of overweight and obesity in Sub-Saharan Africa (SSA). Precise information to understand disease distribution and assess determinants is lacking. Therefore, this dissertation aimed to: (i) analyze the prevalence of adult female overweight and obesity combined in lower-level administrative units; (ii) analyze the effect modification of educational attainment and age on the association between household wealth and adult female overweight and obesity; (iii) synthesize qualitative research evidence to describe contextual factors contributing to female overweight and obesity at different life stages. Bayesian and logistic regression models were constructed with Demographic and Health Survey (DHS) data to respectively estimate the prevalence of overweight and obesity and assess the interaction of education on the association between household wealth and overweight. The synthesis of qualitative research studies was conducted in accordance with PRISMA guidelines and findings were grouped by themes. Prevalence estimates revealed heterogeneity at second-level administrative units in the seven SSA countries examined, which was not visible in first-level administrative units. The combined prevalence of overweight and obesity ranged from 7.5 – 42.0% in Benin, 1.4 – 35.9% in Ethiopia, 1.6 – 44.7% in Mozambique, 1.0 – 67.9% in Nigeria, 2.2 - 72.4% in Tanzania, 3.9 – 39.9% in Zambia, and 4.5 - 50.6% in Zimbabwe. Additionally, education did not have a statistically significant modifying effect on the positive association between household wealth and overweight in the 22 SSA countries eligible for the study. Body shape and size ideals, barriers to healthy food choices and physical activity were key themes in the research synthesis encompassing four SSA countries. Positive symbolism, including beauty, was linked to overweight and obesity in adult women. Among adolescents, although being overweight or obese was not accepted, girls were expected to be voluptuous. Body image dissatisfaction and victimization characterized the experiences of non-conforming women and girls. Barriers to healthy nutrition included migration and the food environment. Whereas, barriers to physical activity included ageism. While additional work is encouraged to validate the prevalence estimates, overweight and obesity interventions must consider whether the determinants identified in this study are relevant to their context to inform improved outcomes.

Subjects/Keywords: overweight; obesity; adult women; sub-Saharan Africa; epidemiology; small area estimation; Epidemiology; International Public Health; Nutritional and Metabolic Diseases

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APA (6^th Edition):

Ozodiegwu, I. (2019). The Prevalence and Context of Adult Female Overweight and Obesity in Sub-Saharan Africa. (Thesis). East Tennessee State University. Retrieved from https://dc.etsu.edu/etd/3566

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ozodiegwu, Ifeoma. “The Prevalence and Context of Adult Female Overweight and Obesity in Sub-Saharan Africa.” 2019. Thesis, East Tennessee State University. Accessed January 28, 2021. https://dc.etsu.edu/etd/3566.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ozodiegwu, Ifeoma. “The Prevalence and Context of Adult Female Overweight and Obesity in Sub-Saharan Africa.” 2019. Web. 28 Jan 2021.

Vancouver:

Ozodiegwu I. The Prevalence and Context of Adult Female Overweight and Obesity in Sub-Saharan Africa. [Internet] [Thesis]. East Tennessee State University; 2019. [cited 2021 Jan 28]. Available from: https://dc.etsu.edu/etd/3566.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ozodiegwu I. The Prevalence and Context of Adult Female Overweight and Obesity in Sub-Saharan Africa. [Thesis]. East Tennessee State University; 2019. Available from: https://dc.etsu.edu/etd/3566

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New Mexico

29. Bartley, Denise S. Evaluation of the New Onset Diabetic Education Program for Navajo Adults.

Degree: College of Nursing, 2018, University of New Mexico

URL: https://digitalrepository.unm.edu/nurs_etds/44

► The prevalence of diabetes mellitus (DM) is higher in American Indians/Alaska Natives (AI/AN) than in any other racial or ethnic group in the United… (more)

▼ The prevalence of diabetes mellitus (DM) is higher in American Indians/Alaska Natives (AI/AN) than in any other racial or ethnic group in the United States (U.S. Department of Health and Human Services [USDHHS] Centers for Disease Control and Prevention [CDC], 2018). In response to this escalating health issue, the U.S. government funded a number of DM education and treatment programs focusing on AI/AN populations. The purpose of this study was to evaluate the New Onset Diabetes Education Program (NODEP) based at Northern Navajo Medical Center (NNMC) in Shiprock, N.M. The Navajo philosophy of learning was used as a guiding framework. This two-phase study examined the effectiveness of NODEP using medical records and survey data. In Phase I, glycosylated hemoglobin (HbA1c) levels and body mass index (BMI) data were collected via retrospective chart reviews on Navajo adults (n = 480) diagnosed with DM and referred to NODEP from January 1, 2010, to December 31, 2015. Study participants were assigned to one of four groups (n = 120): (a) attended a full three-day course; (b) attended a one-day course; (c) began the three-day course but did not complete it; and (d) people who were referred but did not attend any portion of NODEP. During Phase II, a researcher-designed survey was administered prospectively to capture participants’ perspectives on the strengths and weakness of the program as well as on barriers and facilitators to attendance. Participants who attended and completed either version of NODEP at NNMC showed significantly improved levels of HbA1c over 24 months. Participants who completed the three-day course showed a clinically meaningful improvement from a mean of 10.0% at the time of referral to ≤ 7.0% from six to 24 months. Similarly, those who completed the one-day course had a mean HbA1c of 9.3% to ≤ 7.3% from six to 24 months. In contrast, mean HbA1c was never less than 8.0% for those who did not complete or never started the program. Moreover, study participants who did not attend any portion of NODEP showed a statically significant worsening HbA1c level over 24 months. Responses to the survey indicated that a large majority (90.9%) of participants who attended NODEP to completion (n = 77) thought that the most helpful information was “understanding what DM is” and that the least helpful information included discussion of DM medications (9.1%). The most significant barrier to attending NODEP was that it was not held in the outlying communities. Themes from the participants’ comments comprised prevention, management, variation in teaching strategies, self-reliance, outreach programs and challenges. Further, participant recommendations included making NODEP more accessible by teaching the course in rural communities and by providing access to a counselor, traditional healer, or to community support groups. Advisors/Committee Members: Kim Cox, Mark Parshall, Dr. Kimberly Mohs.

Subjects/Keywords: Navajo; Diabetes Education; American Indian; Native American; Diabetes; Adult and Continuing Education; Nursing; Nutritional and Metabolic Diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bartley, D. S. (2018). Evaluation of the New Onset Diabetic Education Program for Navajo Adults. (Doctoral Dissertation). University of New Mexico. Retrieved from https://digitalrepository.unm.edu/nurs_etds/44

Chicago Manual of Style (16^th Edition):

Bartley, Denise S. “Evaluation of the New Onset Diabetic Education Program for Navajo Adults.” 2018. Doctoral Dissertation, University of New Mexico. Accessed January 28, 2021. https://digitalrepository.unm.edu/nurs_etds/44.

MLA Handbook (7^th Edition):

Bartley, Denise S. “Evaluation of the New Onset Diabetic Education Program for Navajo Adults.” 2018. Web. 28 Jan 2021.

Vancouver:

Bartley DS. Evaluation of the New Onset Diabetic Education Program for Navajo Adults. [Internet] [Doctoral dissertation]. University of New Mexico; 2018. [cited 2021 Jan 28]. Available from: https://digitalrepository.unm.edu/nurs_etds/44.

Council of Science Editors:

Bartley DS. Evaluation of the New Onset Diabetic Education Program for Navajo Adults. [Doctoral Dissertation]. University of New Mexico; 2018. Available from: https://digitalrepository.unm.edu/nurs_etds/44

Edith Cowan University

30. Kudiarasu, Christine. Effects of eccentric versus concentric resistance training in adults with Type 2 Diabetes.

Degree: 2020, Edith Cowan University

URL: https://ro.ecu.edu.au/theses/2297

► The benefits of resistance training for people with Type 2 diabetes (T2D) are well documented; however, the effects of different muscle contraction types (e.g. eccentric,… (more)

▼ The benefits of resistance training for people with Type 2 diabetes (T2D) are well documented; however, the effects of different muscle contraction types (e.g. eccentric, concentric) on physiological outcomes for this population are still unclear. This study investigated the effects of eccentric (ECC) versus concentric (CON) resistance training on blood markers, muscle strength, physical functional performance and body composition. Eighteen adults with T2D (Age: 64.8 ± 9.0 y; BMI: 30.3 ± 4.1 kg/m2) were randomly assigned to either an ECC (n = 9) or a CON (n = 9) group. Participants performed 2 or 3 sets of 10 eccentric (5-s) or concentric (2-s) contractions of eight upper and lower body resistance exercises, twice a week for 12 weeks. Training intensity gradually increased from 10 to 100% of 1-repetition maximum concentric strength (1-RM) for the ECC group and from 50 to 100% of 1-RM strength for the CON group, based on the 1-RM at baseline. Blood markers (glucose, insulin, HbA1c, HOMA2-IR, cholesterol, triglycerides, HDL and LDL), muscle strength (1- RM), body composition (dual-energy x-ray absorptiometry), and physical functional performance tests consisting of 6-min walk (6MWT), chair rise (CR), timed up-and-go (TUG), and balance were measured before and after the intervention, and the changes were compared between groups. Significant differences in the improvement between the ECC and CON group were found for 1-RM strength for bicep curl (ECC: 11%, CON: 27%), calf raise (ECC: 37%, CON: 68%) and abdominal crunch (ECC: 22%, CON: 42%) exercises, hip circumference (ECC: -1%, CON: -5%) and SF-36 pain measures (ECC: 6%, CON: -1%). Muscle strength significantly increased more for the CON group (27–68%) than the ECC group (12–37%) which was likely due to greater combined total load lifted in the CON (143,262 ± 57,972 kg) than the ECC group (111,678 ± 51,225 kg). Significant improvements (p < 0.05) were also found in the ECC group for the 6MWT (56.8 ± 2.2 m), TUG (-0.8 ± 0.3 s) and CR (-1.8 ± 1.4 s), while the CON group significantly improved the 6MWT (63.4 ± 12.0 m) and CR (-2.3 ± 1.6 s). Total equilibrium balance increased by 7.0% in the ECC group and 4.3% in the CON group. Body composition improved similarly for both groups including significant reductions in total fat mass (ECC: -2.0 ± 1.3 kg, CON: -2.2 ± 1.2 kg) and significant increase in total lean mass (ECC: 1.8 ± 0.7 kg, CON: 2.0 ± 0.2 kg). No significant changes were found in blood markers for both groups. These results showed that ECC training performed at lower intensities (RPE: 4.1 ± 2.1) was as effective as CON training for improving physical functional performance, strength and body composition. These findings suggest that focusing on eccentric contractions in resistance training is beneficial and well-tolerated in adults with T2D.

Subjects/Keywords: Exercise; eccentric; eccentric exercise; eccentric resistance training; Type 2 Diabetes; Nutritional and Metabolic Diseases; Sports Sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kudiarasu, C. (2020). Effects of eccentric versus concentric resistance training in adults with Type 2 Diabetes. (Thesis). Edith Cowan University. Retrieved from https://ro.ecu.edu.au/theses/2297

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kudiarasu, Christine. “Effects of eccentric versus concentric resistance training in adults with Type 2 Diabetes.” 2020. Thesis, Edith Cowan University. Accessed January 28, 2021. https://ro.ecu.edu.au/theses/2297.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kudiarasu, Christine. “Effects of eccentric versus concentric resistance training in adults with Type 2 Diabetes.” 2020. Web. 28 Jan 2021.

Vancouver:

Kudiarasu C. Effects of eccentric versus concentric resistance training in adults with Type 2 Diabetes. [Internet] [Thesis]. Edith Cowan University; 2020. [cited 2021 Jan 28]. Available from: https://ro.ecu.edu.au/theses/2297.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kudiarasu C. Effects of eccentric versus concentric resistance training in adults with Type 2 Diabetes. [Thesis]. Edith Cowan University; 2020. Available from: https://ro.ecu.edu.au/theses/2297

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations