subject:(Nucleotides)

Oregon State University

1. Albin, Edward Elmo. Cyclic nucleotides, cyclic nucleotide phosphodiesterase, protein kinase, and phosphoprotein phosphatase in the central nervous sytem of Manduca sexta.

Degree: PhD, Biochemistry and Biophysics, 1973, Oregon State University

URL: http://hdl.handle.net/1957/45233

► Adenosine 3', 5' -cyclic monophosphate (cyclic AMP, cAMP) and guanosine 3', 5' -cyclic monophosphate (cyclic GMP, cGMP) were quantitated in the central nervous system (CNS)… (more)

▼ Adenosine 3', 5' -cyclic monophosphate (cyclic AMP, cAMP) and guanosine 3', 5' -cyclic monophosphate (cyclic GMP, cGMP) were quantitated in the central nervous system (CNS) of the insect Manduca sexta by competitive protein binding techniques. The M. sexta CNS was found to contain a strikingly high level of cGMP, about 100-fold greater than that of mammalian brain. The level of cAMP, however, was estimated to be about one-sixth that of mammalian brain. The basal ratio of cGMP/cAMP in the insect CNS was approximately ten, whereas this ratio has been reported to be less than one in a variety of vertebrate and invertebrate tissues. Acetylcholine caused a great elevation of cGMP, but not cAMP, in the M. sexta CNS. Short-term incubation with ecdysterone (insect metamorphosis hormone) promoted the accumulation of both cyclic nucleotides. The existence of cyclic nucleotide- stimulable protein kinases (ATP: protein phosphotransferase, EC 2. 7. 1. 37), a system of enzymes postulated to be instrumental in the biochemical expression of cAMP and cGMP, was demonstrated in the CNS of both larval and adult M. sexta. At low concentrations, cAMP was a much more effective activator of kinase activity than cGMP, Cyclic AMP lowered the Km of the CNS kinase for ATP, a phenomenon which has been reported to be unique to nervous tissue in mammals. A number of the enzymological properties of the insect kinase were similar to those reported in the literature for this enzyme in mammalian tissues. This insect CNS was also shown to possess a potent enzyme system, viz. phosphoprotein phosphatase, for the dephosphorylation of the phosphorylated products of kinase. Phosphatase activity was gauged using phosphoprotamine as substrate. Both kinase and phosphatase activities were found to be enriched in particulate fractions of the CNS. An enzyme system for the destruction of cAMP and cGMP, cyclic nucleotide phosphodiesterase (nucleoside 3', 5' -cyclic phosphate nucleoside 5' -phosphate 31 -phosphohydrolase, EC 3.1. 4< c), was examined in the M. sexta larval and adult CNS. Phosphodiesterase (PDE) was found in both soluble and particulate fractions of the CNS, but highest specific activity PDE was noted in a crude mitochondrial preparation, a fraction presumably containing synaptic elements.PDE was greatly enriched in the brain relative to the other CNS ganglia, and was present at higher levels in nervous relative to nonnervous tissues. The hydrolysis of both cAMP and cGMP appeared to be the function of a single enzyme (or similar isozymes) in the larval CNS. Kinetic evidence suggested that PDE in the insect is a cooperative enzyme and is characterized by non-linear, biphasic double-reciprocal plots. PDE could be effectively inhibited by presumed physiological levels of ATP. Advisors/Committee Members: Newburgh, R. W. (advisor).

Subjects/Keywords: Nucleotides

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APA (6^th Edition):

Albin, E. E. (1973). Cyclic nucleotides, cyclic nucleotide phosphodiesterase, protein kinase, and phosphoprotein phosphatase in the central nervous sytem of Manduca sexta. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/45233

Chicago Manual of Style (16^th Edition):

Albin, Edward Elmo. “Cyclic nucleotides, cyclic nucleotide phosphodiesterase, protein kinase, and phosphoprotein phosphatase in the central nervous sytem of Manduca sexta.” 1973. Doctoral Dissertation, Oregon State University. Accessed February 21, 2020. http://hdl.handle.net/1957/45233.

MLA Handbook (7^th Edition):

Albin, Edward Elmo. “Cyclic nucleotides, cyclic nucleotide phosphodiesterase, protein kinase, and phosphoprotein phosphatase in the central nervous sytem of Manduca sexta.” 1973. Web. 21 Feb 2020.

Vancouver:

Albin EE. Cyclic nucleotides, cyclic nucleotide phosphodiesterase, protein kinase, and phosphoprotein phosphatase in the central nervous sytem of Manduca sexta. [Internet] [Doctoral dissertation]. Oregon State University; 1973. [cited 2020 Feb 21]. Available from: http://hdl.handle.net/1957/45233.

Council of Science Editors:

Albin EE. Cyclic nucleotides, cyclic nucleotide phosphodiesterase, protein kinase, and phosphoprotein phosphatase in the central nervous sytem of Manduca sexta. [Doctoral Dissertation]. Oregon State University; 1973. Available from: http://hdl.handle.net/1957/45233

University of Adelaide

2. Chandler, Bruce Stanford. Spectral studies on thymine deoxyribopolynucleotides.

Degree: 1970, University of Adelaide

URL: http://hdl.handle.net/2440/20685

Subjects/Keywords: Nucleotides.

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APA (6^th Edition):

Chandler, B. S. (1970). Spectral studies on thymine deoxyribopolynucleotides. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/20685

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chandler, Bruce Stanford. “Spectral studies on thymine deoxyribopolynucleotides.” 1970. Thesis, University of Adelaide. Accessed February 21, 2020. http://hdl.handle.net/2440/20685.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chandler, Bruce Stanford. “Spectral studies on thymine deoxyribopolynucleotides.” 1970. Web. 21 Feb 2020.

Vancouver:

Chandler BS. Spectral studies on thymine deoxyribopolynucleotides. [Internet] [Thesis]. University of Adelaide; 1970. [cited 2020 Feb 21]. Available from: http://hdl.handle.net/2440/20685.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chandler BS. Spectral studies on thymine deoxyribopolynucleotides. [Thesis]. University of Adelaide; 1970. Available from: http://hdl.handle.net/2440/20685

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Sun, Xuejun, 1977-. Gas phase studies of hypoxanthine:.

Degree: PhD, Chemistry and Chemical Biology, 2010, Rutgers University

URL: http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000052158

►

Hypoxanthine is not only a naturally occurring nucleobase in tRNA but also a damaged one in DNA arising from oxidative deamination of adenine. This thesis… (more)

▼

Hypoxanthine is not only a naturally occurring nucleobase in tRNA but also a damaged one in DNA arising from oxidative deamination of adenine. This thesis describes studies of the intrinsic reactivity of hypoxanthine as a free base and the stability of DNA duplexes containing hypoxanthine in the gas phase versus in solution by calculation and mass spectrometry methods. Firstly, the free base of hypoxanthine is studied as a damaged nucleobase. Hypoxanthine is one of the damaged nucleobases that can be excised by Alkyladenine DNA glycosylase (AAG) in humans. To understand the intrinsic properties of hypoxanthine, we examined the gas phase acidity and proton affinity using quantum mechanical calculations and gas-phase mass spectrometric experimental methods. We find that the N9-H of hypoxanthine is more acidic than that of adenine and guanine, pointing to a way by which AAG may discriminate damaged bases from normal bases. We hypothesize that AAG may cleave certain damaged nucleobases as anions and the active site may take advantage of a nonpolar environment to favor deprotonated hypoxanthine as a better leaving group than adenine and guanine. The acidities of AAG substrates have been compared with those of normal bases by calculations and Cooks kinetics method. In addition, the acidity differences between damaged and normal bases are enhanced in the gas phase when we compare them with the acidities in solution. These results support our hypothesis. Secondly, to understand the effect of hypoxanthine on DNA stability, we study a series of 9-mer DNA duplexes with the sequence 5'-d(GGTTXTTGG)-3'/3'-d(CCAAYAACC)-5', where the central base X or Y = adenine (A), guanine (G), thymine (T), cytosine (C) and hypoxanthine (H). Comparison of the duplex stability in the gas phase versus in solution indicates that hypoxanthine has much less of a destabilizing effect in the gas phase versus in solution, relative to the normal complementary duplexes. The biological implications of these results are discussed in the context of hypoxanthine both as a universal base and as a damaged base.

Advisors/Committee Members: Sun, Xuejun, 1977- (author), Lee, Jeehiun (chair), Goldman, Alan (internal member), Warmuth, Ralf (internal member), Buckley, Brian (outside member).

Subjects/Keywords: Nucleotides

…long chain polymer of linked nucleotides; 5 each nucleotide is composed of a nucleobase, a…

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APA (6^th Edition):

Sun, Xuejun, 1. (2010). Gas phase studies of hypoxanthine:. (Doctoral Dissertation). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000052158

Chicago Manual of Style (16^th Edition):

Sun, Xuejun, 1977-. “Gas phase studies of hypoxanthine:.” 2010. Doctoral Dissertation, Rutgers University. Accessed February 21, 2020. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000052158.

MLA Handbook (7^th Edition):

Sun, Xuejun, 1977-. “Gas phase studies of hypoxanthine:.” 2010. Web. 21 Feb 2020.

Vancouver:

Sun, Xuejun 1. Gas phase studies of hypoxanthine:. [Internet] [Doctoral dissertation]. Rutgers University; 2010. [cited 2020 Feb 21]. Available from: http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000052158.

Council of Science Editors:

Sun, Xuejun 1. Gas phase studies of hypoxanthine:. [Doctoral Dissertation]. Rutgers University; 2010. Available from: http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000052158

Michigan State University

4. Marshall, Christopher Lyle. Sodium 5'-guanosine monophosphate aggregation : stoichiometry, modes of specific sodium ion complexation, and binding to ethidium.

Degree: PhD, Department of Chemistry, 1980, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:41448

Subjects/Keywords: Nucleotides

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APA (6^th Edition):

Marshall, C. L. (1980). Sodium 5'-guanosine monophosphate aggregation : stoichiometry, modes of specific sodium ion complexation, and binding to ethidium. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:41448

Chicago Manual of Style (16^th Edition):

Marshall, Christopher Lyle. “Sodium 5'-guanosine monophosphate aggregation : stoichiometry, modes of specific sodium ion complexation, and binding to ethidium.” 1980. Doctoral Dissertation, Michigan State University. Accessed February 21, 2020. http://etd.lib.msu.edu/islandora/object/etd:41448.

MLA Handbook (7^th Edition):

Marshall, Christopher Lyle. “Sodium 5'-guanosine monophosphate aggregation : stoichiometry, modes of specific sodium ion complexation, and binding to ethidium.” 1980. Web. 21 Feb 2020.

Vancouver:

Marshall CL. Sodium 5'-guanosine monophosphate aggregation : stoichiometry, modes of specific sodium ion complexation, and binding to ethidium. [Internet] [Doctoral dissertation]. Michigan State University; 1980. [cited 2020 Feb 21]. Available from: http://etd.lib.msu.edu/islandora/object/etd:41448.

Council of Science Editors:

Marshall CL. Sodium 5'-guanosine monophosphate aggregation : stoichiometry, modes of specific sodium ion complexation, and binding to ethidium. [Doctoral Dissertation]. Michigan State University; 1980. Available from: http://etd.lib.msu.edu/islandora/object/etd:41448

Hong Kong University of Science and Technology

5. Lin, Li. Nucleotides-mediated size differentiation of gold nanoparticles and its application for enzymatic assay.

Degree: 2011, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-7138 ; https://doi.org/10.14711/thesis-b1136621 ; http://repository.ust.hk/ir/bitstream/1783.1-7138/1/th_redirect.html

► Gold nanoparticles (Au-nps) are one of the most attractive nanomaterials used in nanotechnology and biomedical science. The wide applications of nanoparticles are highly dependent on… (more)

Subjects/Keywords: Nanoparticles – Synthesis ; Nucleotides

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APA (6^th Edition):

Lin, L. (2011). Nucleotides-mediated size differentiation of gold nanoparticles and its application for enzymatic assay. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-7138 ; https://doi.org/10.14711/thesis-b1136621 ; http://repository.ust.hk/ir/bitstream/1783.1-7138/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lin, Li. “Nucleotides-mediated size differentiation of gold nanoparticles and its application for enzymatic assay.” 2011. Thesis, Hong Kong University of Science and Technology. Accessed February 21, 2020. http://repository.ust.hk/ir/Record/1783.1-7138 ; https://doi.org/10.14711/thesis-b1136621 ; http://repository.ust.hk/ir/bitstream/1783.1-7138/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lin, Li. “Nucleotides-mediated size differentiation of gold nanoparticles and its application for enzymatic assay.” 2011. Web. 21 Feb 2020.

Vancouver:

Lin L. Nucleotides-mediated size differentiation of gold nanoparticles and its application for enzymatic assay. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2011. [cited 2020 Feb 21]. Available from: http://repository.ust.hk/ir/Record/1783.1-7138 ; https://doi.org/10.14711/thesis-b1136621 ; http://repository.ust.hk/ir/bitstream/1783.1-7138/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lin L. Nucleotides-mediated size differentiation of gold nanoparticles and its application for enzymatic assay. [Thesis]. Hong Kong University of Science and Technology; 2011. Available from: http://repository.ust.hk/ir/Record/1783.1-7138 ; https://doi.org/10.14711/thesis-b1136621 ; http://repository.ust.hk/ir/bitstream/1783.1-7138/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

The Ohio State University

6. Pagnucco, Rinaldo Gene. Synthesis of purine nucleosides of D-galactose and D-galacturonic acid derivatives.

Degree: PhD, Graduate School, 1965, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486567958464259

Subjects/Keywords: Chemistry; Nucleotides

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APA (6^th Edition):

Pagnucco, R. G. (1965). Synthesis of purine nucleosides of D-galactose and D-galacturonic acid derivatives. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1486567958464259

Chicago Manual of Style (16^th Edition):

Pagnucco, Rinaldo Gene. “Synthesis of purine nucleosides of D-galactose and D-galacturonic acid derivatives.” 1965. Doctoral Dissertation, The Ohio State University. Accessed February 21, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486567958464259.

MLA Handbook (7^th Edition):

Pagnucco, Rinaldo Gene. “Synthesis of purine nucleosides of D-galactose and D-galacturonic acid derivatives.” 1965. Web. 21 Feb 2020.

Vancouver:

Pagnucco RG. Synthesis of purine nucleosides of D-galactose and D-galacturonic acid derivatives. [Internet] [Doctoral dissertation]. The Ohio State University; 1965. [cited 2020 Feb 21]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486567958464259.

Council of Science Editors:

Pagnucco RG. Synthesis of purine nucleosides of D-galactose and D-galacturonic acid derivatives. [Doctoral Dissertation]. The Ohio State University; 1965. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486567958464259

University of Utah

7. Westcott, Wayne L. The chemistry of the nucleic acids.

Degree: MS;, Biochemistry;, 1949, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/198/rec/1146

► Much more is known about the components of pentose nucleic acid than is known about those of desoxypentose nucleic acid. However, the manner of the… (more)

▼ Much more is known about the components of pentose nucleic acid than is known about those of desoxypentose nucleic acid. However, the manner of the inter-nucleotide linkage of both is still unknown. An experimental approach was suggested in an attempt to settle this point for the pentose nucleic acids. Because of the extreme lability of the carbohydrate component of the desoxypentose nucleic acid a different experimental approach to the problem of inter-nucleotide linkage must be found. 2-desoxy-D-ribose has been demonstrated only in the guanosine isolated from the desoxypentose nucleic acid and its furatnose structure was demonstrated indirectly in thymidine. Infra-red studies might be carried out by determining the characteristic patters of all the known constituents of both types of the nucleic acids as well as of the nucleic acids isolated from different sources and “purified” by different methods. In this manner it may be possible to gain an insight into the over-all structures of the nucleic acid macromolecules. Studies with labeled nitrogen in the ring structure of the nitrogenous bases should be extended. The amount of each of the nitrogenous bases in the different nucleic acids could be readily determined by means of isotope dilution using the paper chromatograph for final separation. The incorporation of N15 in the ring structure of adenine at position (7) or (9) would provide a labeled nitrogenous base. This would be added to the nucleic acid before hydrolysis. The adenosine could be isolated from the hydrolysate chromatographically and the amount of adenine originally present in the nucleic acid could be determined. This procedure would have to be repeated for each nitrogenous base in order to determine the amounts originally present in the nucleic acids. Enzymatic studies also have shown the probability of more than one type of inter-nucleotide linkage occurring within the nucleic acid macromolecule. One type is thought to be quite resistant to enzymatic action as only about thirty percent of the nucleic acid is hydrolyzed under optimal conditions. It is suggested that the nucleic acids be partially hydrolyzed by the “depolymerases” and that both the hydrolyzed and non-hydrolyzed fractions be subjected to exhaustive methylation. Subsequent determinations of the carbohydrate oxidation products would aid in the location of the inter-nucleotide linkages.

Subjects/Keywords: Analysis; Nucleotides

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APA (6^th Edition):

Westcott, W. L. (1949). The chemistry of the nucleic acids. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/198/rec/1146

Chicago Manual of Style (16^th Edition):

Westcott, Wayne L. “The chemistry of the nucleic acids.” 1949. Masters Thesis, University of Utah. Accessed February 21, 2020. http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/198/rec/1146.

MLA Handbook (7^th Edition):

Westcott, Wayne L. “The chemistry of the nucleic acids.” 1949. Web. 21 Feb 2020.

Vancouver:

Westcott WL. The chemistry of the nucleic acids. [Internet] [Masters thesis]. University of Utah; 1949. [cited 2020 Feb 21]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/198/rec/1146.

Council of Science Editors:

Westcott WL. The chemistry of the nucleic acids. [Masters Thesis]. University of Utah; 1949. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/198/rec/1146

University of Georgia

8. Jung, Byoungyun. Evaluation of dietary nucleotides for broilers.

Degree: PhD, Poultry Science, 2011, University of Georgia

URL: http://purl.galileo.usg.edu/uga_etd/jung_byoungyun_201105_phd

► Nucleotides are the basic units that make up nucleic acids, such as deoxyribonucleic acd (DNA) and ribonucleic acid (RNA). Nucleotides are involved in many biological… (more)

▼ Nucleotides are the basic units that make up nucleic acids, such as deoxyribonucleic acd (DNA) and ribonucleic acid (RNA). Nucleotides are involved in many biological processes. They are important in nucleic acids (e.g. DNAs and RNAs) synthesis and as a source of cellular energy. They affect the immune system and are involved in physiological and morphological changes in small intestinal development. Nucleotides are not considered an essential nutrient because they can be synthesized by a de novo pathway from amino acid precursors and recycled through a salvage pathway. However, these mechanisms may not always be adequate to supply nucleotides for an organism during times of stress. Stressors which may impact nucleotide requirements include high stocking density, unsanitary conditions, disease challenges, and recovery from injuries. A series of experiments were conducted to determine the effect of the dietary nucleotides on the performance and development of the gastrointestinal tract (GIT) of broilers under certain stress conditions. In the first experiment, Torula yeast RNA (as a source of dietary nucleotide supplementation) and a commercial nucleotide product (Nupro®) were fed to broilers raised under normal conditions and environmental stressed conditions; previously used litter. Body weight gain, feed intake, feed conversion ratios, mortality, and physical and morphological development of the gastrointestinal tract were measured. Supplementing the diet with dietary nucleotides had no effect on performance of broilers under normal conditions; however, dietary nucleotide supplementation improved performance of birds reared in previously used litter. In the second experiment, the effect of Torula yeast RNA supplementation on performance, intestinal tract development and morphology of broilers challenged with a high-dose Coccivac-B® vaccine and reared in an increased stocking density were determined. Supplementing the diets with Torula yeast RNA had improved performance of birds challenged with a high-dose Coccivac-B® vaccine and reared in the increased stocking density conditions. In the third experiment, two dietary nucleotides (Torula yeast RNA and Nupro®) and a nucleotide precursor (glutamine) were fed to broilers challenged with Coccivac-B® vaccine. Broiler performance and nutrient utilization (nitrogen corrected apparent metabolizable energy; AMEN) were measured. Dietary nucleotide (0.25% Torula yeast RNA and 2% Nupro®) supplementation was effective at alleviating the negative effects of Coccidiosis vaccine challenge. The increased AMEN value of diets with supplemental levels of Torula yeast RNA and Nupro® resulted in increased growth performance. However, the supplementation of a nucleotide precursor, glutamine, did not replace nucleotides in broilers. In the fourth experiment, Torula yeast RNA was added to semi-purified diets containg high levels of casein or crystalline amino acids mixture of broilers challenged with Coccivac-B® vaccine. Performance and relative weight, morphology, and gross lesion score… Advisors/Committee Members: Amy Batal.

Subjects/Keywords: Nucleotides; Performance; Stress conditions

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APA (6^th Edition):

Jung, B. (2011). Evaluation of dietary nucleotides for broilers. (Doctoral Dissertation). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/jung_byoungyun_201105_phd

Chicago Manual of Style (16^th Edition):

Jung, Byoungyun. “Evaluation of dietary nucleotides for broilers.” 2011. Doctoral Dissertation, University of Georgia. Accessed February 21, 2020. http://purl.galileo.usg.edu/uga_etd/jung_byoungyun_201105_phd.

MLA Handbook (7^th Edition):

Jung, Byoungyun. “Evaluation of dietary nucleotides for broilers.” 2011. Web. 21 Feb 2020.

Vancouver:

Jung B. Evaluation of dietary nucleotides for broilers. [Internet] [Doctoral dissertation]. University of Georgia; 2011. [cited 2020 Feb 21]. Available from: http://purl.galileo.usg.edu/uga_etd/jung_byoungyun_201105_phd.

Council of Science Editors:

Jung B. Evaluation of dietary nucleotides for broilers. [Doctoral Dissertation]. University of Georgia; 2011. Available from: http://purl.galileo.usg.edu/uga_etd/jung_byoungyun_201105_phd

University of Utah

9. Clemons, William Melvon. Structure of the small ribosomal subunit;.

Degree: PhD, Biochemistry;, 2000, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/271/rec/1255

► The ribosome is one of the most important components of the cell. It is solely responsible for protein synthesis in every organism. Aside from its… (more)

Subjects/Keywords: Genetics; Nucleotides

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APA (6^th Edition):

Clemons, W. M. (2000). Structure of the small ribosomal subunit;. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/271/rec/1255

Chicago Manual of Style (16^th Edition):

Clemons, William Melvon. “Structure of the small ribosomal subunit;.” 2000. Doctoral Dissertation, University of Utah. Accessed February 21, 2020. http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/271/rec/1255.

MLA Handbook (7^th Edition):

Clemons, William Melvon. “Structure of the small ribosomal subunit;.” 2000. Web. 21 Feb 2020.

Vancouver:

Clemons WM. Structure of the small ribosomal subunit;. [Internet] [Doctoral dissertation]. University of Utah; 2000. [cited 2020 Feb 21]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/271/rec/1255.

Council of Science Editors:

Clemons WM. Structure of the small ribosomal subunit;. [Doctoral Dissertation]. University of Utah; 2000. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/271/rec/1255

Texas A&M University

10. Anguiano, Maritza. Effects of Dietary Nucleotides on Growth, Immunology, and Disease Resistance of Juvenile Nile Tilapia (Oreochromis niloticus).

Degree: 2012, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2011-12-10403

► In order to improve production efficiency and profitability in tilapia aquaculture, further research is needed to develop methods to improve weight gain, feed utilization, and… (more)

▼ In order to improve production efficiency and profitability in tilapia aquaculture, further research is needed to develop methods to improve weight gain, feed utilization, and immune function of these fish. In this regard, numerous studies with several fish species have reported that dietary nucleotides can enhance growth performance, immune responses and disease resistance. Therefore, two feeding experiments were conducted to investigate the effects of a purified nucleotide mix on juvenile Nile tilapia, Oreochromis niloticus. A basal diet was formulated to contain 34% crude protein from fishmeal and soybean meal. A nucleotide mix containing salts of cytidine, uridine, adenosine, inosine, guanosine, and thymine was supplemented to the basal diet at 0.5, 1 and 2% of dry weight. In the first experiment, three replicate groups of 15 fish were fed the experimental diets. At the end of 8 weeks, weight gain, feed efficiency and survival were computed. Blood samples were analyzed for neutrophil oxidative radical production and plasma lysozyme activity. In the second trial, three replicate groups of 20 fish were fed the same experimental diets. At the end of 4 weeks, blood and kidney samples were analyzed for macrophage extracellular and intracellular superoxide anion production, blood neutrophil oxidative radical production, plasma lysozyme activity, and peripheral blood lymphocyte proliferation. Then, 12 fish per treatment were challenged with Streptococcus iniae, via intraperitoneal injection, and mortality was recorded for 21 days. Results showed that none of the nucleotide-supplemented diets induced significant (P < 0.05) effects on growth performance. On the other hand, the 0.5% treatment produced significantly (P < 0.05) higher intracellular superoxide anion (O2-) production and both the 0.5 and 1% treatments significantly (P < 0.05) increased lymphocyte proliferation. The disease challenge failed to show significant survival differences among treatments; however, the 2% nucleotide treatment tended to produce higher survivability. Results from both experiments lead to the conclusion that this particular nucleotide mix does not provide marked improvements in growth performance and disease resistance; however, dietary nucleotide supplementation did affect some components of the immune system of Nile tilapia. Advisors/Committee Members: Buentello, Alejandro (advisor), Gatlin III, Delbert M. (advisor), Lupiani, Blanca (committee member).

Subjects/Keywords: Nile tilapia; nucleotides; Streptococcus iniae

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APA (6^th Edition):

Anguiano, M. (2012). Effects of Dietary Nucleotides on Growth, Immunology, and Disease Resistance of Juvenile Nile Tilapia (Oreochromis niloticus). (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2011-12-10403

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Anguiano, Maritza. “Effects of Dietary Nucleotides on Growth, Immunology, and Disease Resistance of Juvenile Nile Tilapia (Oreochromis niloticus).” 2012. Thesis, Texas A&M University. Accessed February 21, 2020. http://hdl.handle.net/1969.1/ETD-TAMU-2011-12-10403.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Anguiano, Maritza. “Effects of Dietary Nucleotides on Growth, Immunology, and Disease Resistance of Juvenile Nile Tilapia (Oreochromis niloticus).” 2012. Web. 21 Feb 2020.

Vancouver:

Anguiano M. Effects of Dietary Nucleotides on Growth, Immunology, and Disease Resistance of Juvenile Nile Tilapia (Oreochromis niloticus). [Internet] [Thesis]. Texas A&M University; 2012. [cited 2020 Feb 21]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2011-12-10403.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Anguiano M. Effects of Dietary Nucleotides on Growth, Immunology, and Disease Resistance of Juvenile Nile Tilapia (Oreochromis niloticus). [Thesis]. Texas A&M University; 2012. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2011-12-10403

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Oregon State University

11. Marchitto, Kevin Scott. The metabolism of 5'-deoxy-5'-methylthioadenosine in Saccharomyces cerevisiae.

Degree: PhD, Microbiology, 1982, Oregon State University

URL: http://hdl.handle.net/1957/41686

Subjects/Keywords: Nucleotides – Metabolism

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APA (6^th Edition):

Marchitto, K. S. (1982). The metabolism of 5'-deoxy-5'-methylthioadenosine in Saccharomyces cerevisiae. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/41686

Chicago Manual of Style (16^th Edition):

Marchitto, Kevin Scott. “The metabolism of 5'-deoxy-5'-methylthioadenosine in Saccharomyces cerevisiae.” 1982. Doctoral Dissertation, Oregon State University. Accessed February 21, 2020. http://hdl.handle.net/1957/41686.

MLA Handbook (7^th Edition):

Marchitto, Kevin Scott. “The metabolism of 5'-deoxy-5'-methylthioadenosine in Saccharomyces cerevisiae.” 1982. Web. 21 Feb 2020.

Vancouver:

Marchitto KS. The metabolism of 5'-deoxy-5'-methylthioadenosine in Saccharomyces cerevisiae. [Internet] [Doctoral dissertation]. Oregon State University; 1982. [cited 2020 Feb 21]. Available from: http://hdl.handle.net/1957/41686.

Council of Science Editors:

Marchitto KS. The metabolism of 5'-deoxy-5'-methylthioadenosine in Saccharomyces cerevisiae. [Doctoral Dissertation]. Oregon State University; 1982. Available from: http://hdl.handle.net/1957/41686

University of Hong Kong

12. Wang, Yong. Evolution mechanisms and biological significance of CG dinucleotide compositional bias in genomes.

Degree: PhD, 2003, University of Hong Kong

URL: Wang, Y. [王勇]. (2003). Evolution mechanisms and biological significance of CG dinucleotide compositional bias in genomes. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b2777749 ; http://dx.doi.org/10.5353/th_b2777749 ; http://hdl.handle.net/10722/30444

published_or_final_version

abstract

toc

Zoology

Doctoral

Doctor of Philosophy

Advisors/Committee Members: Leung, FCC.

Subjects/Keywords: Genomes.; Nucleotides.

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APA (6^th Edition):

Wang, Y. (2003). Evolution mechanisms and biological significance of CG dinucleotide compositional bias in genomes. (Doctoral Dissertation). University of Hong Kong. Retrieved from Wang, Y. [王勇]. (2003). Evolution mechanisms and biological significance of CG dinucleotide compositional bias in genomes. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b2777749 ; http://dx.doi.org/10.5353/th_b2777749 ; http://hdl.handle.net/10722/30444

Chicago Manual of Style (16^th Edition):

Wang, Yong. “Evolution mechanisms and biological significance of CG dinucleotide compositional bias in genomes.” 2003. Doctoral Dissertation, University of Hong Kong. Accessed February 21, 2020. Wang, Y. [王勇]. (2003). Evolution mechanisms and biological significance of CG dinucleotide compositional bias in genomes. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b2777749 ; http://dx.doi.org/10.5353/th_b2777749 ; http://hdl.handle.net/10722/30444.

MLA Handbook (7^th Edition):

Wang, Yong. “Evolution mechanisms and biological significance of CG dinucleotide compositional bias in genomes.” 2003. Web. 21 Feb 2020.

Vancouver:

Wang Y. Evolution mechanisms and biological significance of CG dinucleotide compositional bias in genomes. [Internet] [Doctoral dissertation]. University of Hong Kong; 2003. [cited 2020 Feb 21]. Available from: Wang, Y. [王勇]. (2003). Evolution mechanisms and biological significance of CG dinucleotide compositional bias in genomes. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b2777749 ; http://dx.doi.org/10.5353/th_b2777749 ; http://hdl.handle.net/10722/30444.

Council of Science Editors:

Wang Y. Evolution mechanisms and biological significance of CG dinucleotide compositional bias in genomes. [Doctoral Dissertation]. University of Hong Kong; 2003. Available from: Wang, Y. [王勇]. (2003). Evolution mechanisms and biological significance of CG dinucleotide compositional bias in genomes. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b2777749 ; http://dx.doi.org/10.5353/th_b2777749 ; http://hdl.handle.net/10722/30444

University of Southern California

13. Ismail, Rehana. Bisphosphonates for modified nucleotide synthesis and related chemistry.

Degree: PhD, Chemistry, 2009, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/564078/rec/1131

► This dissertation explores the field of organophosphorus chemistry. Phosphorus plays a major role in medicinal and natural product chemistry, which is the inspiration for the… (more)

Subjects/Keywords: bisphosphonates; modified nucleotides; phosphorus

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APA (6^th Edition):

Ismail, R. (2009). Bisphosphonates for modified nucleotide synthesis and related chemistry. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/564078/rec/1131

Chicago Manual of Style (16^th Edition):

Ismail, Rehana. “Bisphosphonates for modified nucleotide synthesis and related chemistry.” 2009. Doctoral Dissertation, University of Southern California. Accessed February 21, 2020. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/564078/rec/1131.

MLA Handbook (7^th Edition):

Ismail, Rehana. “Bisphosphonates for modified nucleotide synthesis and related chemistry.” 2009. Web. 21 Feb 2020.

Vancouver:

Ismail R. Bisphosphonates for modified nucleotide synthesis and related chemistry. [Internet] [Doctoral dissertation]. University of Southern California; 2009. [cited 2020 Feb 21]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/564078/rec/1131.

Council of Science Editors:

Ismail R. Bisphosphonates for modified nucleotide synthesis and related chemistry. [Doctoral Dissertation]. University of Southern California; 2009. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/564078/rec/1131

University of Southern California

14. Chamberlain, Brian Thomas. Deoxynucleotide analog probes and model compounds for studying DNA polymerase structure and mechanism: synthesis and evaluation of alkyl-, azido-, and halomethylene bisphosphonate-substituted triphosphates.

Degree: PhD, Chemistry, 2012, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/44705/rec/1837

► A variety of triphosphate analogs that replace a natural phosphate anhydride P-O-P linkage with a phosphonate P-CXY-P moiety have been synthesized for the characterization of… (more)

▼ A variety of triphosphate analogs that replace a natural phosphate anhydride P-O-P linkage with a phosphonate P-CXY-P moiety have been synthesized for the characterization of DNA polymerase β (pol β) mechanism and structure. A suite of β,γ-CXY-dTTP compounds (X,Y = H, F, Cl, Br) was synthesized to complement a previous study conducted with series of β,γ-CXY-dGTP analogs. The high purity of the β,γ-CXY-dTTP following dual-pass HPLC purification is demonstrated by NMR, MS, and HPLC data and illustrates the merit of the DCC-mediated morpholidate coupling approach to Pᵦ-CXY-Pᵧ triphosphate mimics. ❧ Novel α-azido bisphosphonates [(RO)₂P(O)]₂CXN₃ (R = i-Pr, X = Me; R = i-Pr, X = H; R = H, X = Me; and R = H, X = H) were developed to examine the impact of the unique azido steric profile on the synthesis and bioactivity of α,β-CXN₃ and β,γ-CXN₃ dNTP analogs. For one example, α,β-CMeN₃-dATP, RP HPLC separated dADP precursors that were used to generate the first examples of nucleoside triphosphate analogs with isolated stereochemistry at an asymmetrically substituted bridging carbon. The acidity constants of the α-azido bisphosphonic acids were determined by potentiometric titration and selected reactions including reduction and UV photolysis are introduced. ❧ The α,β-C(Me)₂-dATP and (R/S)-α,β-CHF-dATP analogs were synthesized and, together with the α,β-CXN₃ dATP analogs, the binding affinities (Kd) with pol β were determined. (R/S)-α,β-CHF-dATP was crystallized with a DNA-pol β binary complex. X-ray structure analysis revealed only the (S)-α,β-CFH-dATP diastereomer was present in the enzyme active site. Analysis of this structure provides evidence for a non-covalent stabilizing interaction between an active site water bound to Asp276 and the fluorine in (S)-α,β-CFH-dATP. Molecular docking studies further demonstrate the importance of this structural water by suggesting a steric clash with the methyl group of α,β-C(Me)2-dATP. ❧ A series of novel β,γ-CH₂, -CHF, and -CF₂ bisphosphonophosphate alkyl monoesters were synthesized and used as model compounds intended to estimate the activation parameters for the non-enzymatic hydrolysis of the triphosphate Pα-O-Pᵦ moiety. ¹⁸O-labeled water experiments showed that the exclusive site of nucleophilic attack in these systems is at Pᵦ. Thus, the catalytic efficiency for a small class of diphosphokinases could be approximated and the upper limit for the rate of non-enzymatic hydrolysis at Pα established. Supplementary compounds that increase Pᵦ-O bond stability by substituting Pᵧ with a phenyl ring are introduced. Preliminary hydrolysis experiments of these compounds highlight the relative stability of the Pα-O anhydride bond in triphosphates. Advisors/Committee Members: McKenna, Charles E. (Committee Chair), Goodman, Myron F. (Committee Member), Haworth, Ian S. (Committee Member).

Subjects/Keywords: bisphosphonates; organoazides; nucleotides; polymerase

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APA (6^th Edition):

Chamberlain, B. T. (2012). Deoxynucleotide analog probes and model compounds for studying DNA polymerase structure and mechanism: synthesis and evaluation of alkyl-, azido-, and halomethylene bisphosphonate-substituted triphosphates. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/44705/rec/1837

Chicago Manual of Style (16^th Edition):

Chamberlain, Brian Thomas. “Deoxynucleotide analog probes and model compounds for studying DNA polymerase structure and mechanism: synthesis and evaluation of alkyl-, azido-, and halomethylene bisphosphonate-substituted triphosphates.” 2012. Doctoral Dissertation, University of Southern California. Accessed February 21, 2020. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/44705/rec/1837.

MLA Handbook (7^th Edition):

Chamberlain, Brian Thomas. “Deoxynucleotide analog probes and model compounds for studying DNA polymerase structure and mechanism: synthesis and evaluation of alkyl-, azido-, and halomethylene bisphosphonate-substituted triphosphates.” 2012. Web. 21 Feb 2020.

Vancouver:

Chamberlain BT. Deoxynucleotide analog probes and model compounds for studying DNA polymerase structure and mechanism: synthesis and evaluation of alkyl-, azido-, and halomethylene bisphosphonate-substituted triphosphates. [Internet] [Doctoral dissertation]. University of Southern California; 2012. [cited 2020 Feb 21]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/44705/rec/1837.

Council of Science Editors:

Chamberlain BT. Deoxynucleotide analog probes and model compounds for studying DNA polymerase structure and mechanism: synthesis and evaluation of alkyl-, azido-, and halomethylene bisphosphonate-substituted triphosphates. [Doctoral Dissertation]. University of Southern California; 2012. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/44705/rec/1837

Montana State University

15. Wilson, Robert Wilfred. Polarized fluorescence of the dinucleotides.

Degree: College of Letters & Science, 1974, Montana State University

URL: https://scholarworks.montana.edu/xmlui/handle/1/4671

Subjects/Keywords: Nucleotides.; Fluorescence.

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APA (6^th Edition):

Wilson, R. W. (1974). Polarized fluorescence of the dinucleotides. (Thesis). Montana State University. Retrieved from https://scholarworks.montana.edu/xmlui/handle/1/4671

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wilson, Robert Wilfred. “Polarized fluorescence of the dinucleotides.” 1974. Thesis, Montana State University. Accessed February 21, 2020. https://scholarworks.montana.edu/xmlui/handle/1/4671.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wilson, Robert Wilfred. “Polarized fluorescence of the dinucleotides.” 1974. Web. 21 Feb 2020.

Vancouver:

Wilson RW. Polarized fluorescence of the dinucleotides. [Internet] [Thesis]. Montana State University; 1974. [cited 2020 Feb 21]. Available from: https://scholarworks.montana.edu/xmlui/handle/1/4671.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wilson RW. Polarized fluorescence of the dinucleotides. [Thesis]. Montana State University; 1974. Available from: https://scholarworks.montana.edu/xmlui/handle/1/4671

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Montana State University

16. Morgan, James Paul. Photochemistry and photophysics of guanines.

Degree: College of Letters & Science, 1974, Montana State University

URL: https://scholarworks.montana.edu/xmlui/handle/1/4458

Subjects/Keywords: Nucleotides.; Photochemistry.

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APA (6^th Edition):

Morgan, J. P. (1974). Photochemistry and photophysics of guanines. (Thesis). Montana State University. Retrieved from https://scholarworks.montana.edu/xmlui/handle/1/4458

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Morgan, James Paul. “Photochemistry and photophysics of guanines.” 1974. Thesis, Montana State University. Accessed February 21, 2020. https://scholarworks.montana.edu/xmlui/handle/1/4458.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Morgan, James Paul. “Photochemistry and photophysics of guanines.” 1974. Web. 21 Feb 2020.

Vancouver:

Morgan JP. Photochemistry and photophysics of guanines. [Internet] [Thesis]. Montana State University; 1974. [cited 2020 Feb 21]. Available from: https://scholarworks.montana.edu/xmlui/handle/1/4458.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Morgan JP. Photochemistry and photophysics of guanines. [Thesis]. Montana State University; 1974. Available from: https://scholarworks.montana.edu/xmlui/handle/1/4458

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McGill University

17. Cormier, James. The synthesis of nucleoside and silyl nucleotide analogues.

Degree: PhD, Department of Chemistry., 1987, McGill University

URL: http://digitool.library.mcgill.ca/thesisfile75458.pdf

►

A route to the synthesis of arabino and xylonucleosides is described. This route takes advantage of highly selective ribonucleoside hydroxyl protection procedures which have recently… (more)

Subjects/Keywords: Nucleosides; Nucleotides

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APA (6^th Edition):

Cormier, J. (1987). The synthesis of nucleoside and silyl nucleotide analogues. (Doctoral Dissertation). McGill University. Retrieved from http://digitool.library.mcgill.ca/thesisfile75458.pdf

Chicago Manual of Style (16^th Edition):

Cormier, James. “The synthesis of nucleoside and silyl nucleotide analogues.” 1987. Doctoral Dissertation, McGill University. Accessed February 21, 2020. http://digitool.library.mcgill.ca/thesisfile75458.pdf.

MLA Handbook (7^th Edition):

Cormier, James. “The synthesis of nucleoside and silyl nucleotide analogues.” 1987. Web. 21 Feb 2020.

Vancouver:

Cormier J. The synthesis of nucleoside and silyl nucleotide analogues. [Internet] [Doctoral dissertation]. McGill University; 1987. [cited 2020 Feb 21]. Available from: http://digitool.library.mcgill.ca/thesisfile75458.pdf.

Council of Science Editors:

Cormier J. The synthesis of nucleoside and silyl nucleotide analogues. [Doctoral Dissertation]. McGill University; 1987. Available from: http://digitool.library.mcgill.ca/thesisfile75458.pdf

McGill University

18. Gillen, Michael Francis. Synthesis and properties of novel nucleoside and nucleotide analogues : a thesis.

Degree: PhD, Department of Chemistry, 1980, McGill University

URL: http://digitool.library.mcgill.ca/thesisfile68566.pdf

►

The synthesis of novel nucleoside and nucleotide analogues in which the sugar moiety is replaced by an aliphatic chain is described. The acyclic analogue of… (more)

Subjects/Keywords: Nucleosides.; Nucleotides.

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APA (6^th Edition):

Gillen, M. F. (1980). Synthesis and properties of novel nucleoside and nucleotide analogues : a thesis. (Doctoral Dissertation). McGill University. Retrieved from http://digitool.library.mcgill.ca/thesisfile68566.pdf

Chicago Manual of Style (16^th Edition):

Gillen, Michael Francis. “Synthesis and properties of novel nucleoside and nucleotide analogues : a thesis.” 1980. Doctoral Dissertation, McGill University. Accessed February 21, 2020. http://digitool.library.mcgill.ca/thesisfile68566.pdf.

MLA Handbook (7^th Edition):

Gillen, Michael Francis. “Synthesis and properties of novel nucleoside and nucleotide analogues : a thesis.” 1980. Web. 21 Feb 2020.

Vancouver:

Gillen MF. Synthesis and properties of novel nucleoside and nucleotide analogues : a thesis. [Internet] [Doctoral dissertation]. McGill University; 1980. [cited 2020 Feb 21]. Available from: http://digitool.library.mcgill.ca/thesisfile68566.pdf.

Council of Science Editors:

Gillen MF. Synthesis and properties of novel nucleoside and nucleotide analogues : a thesis. [Doctoral Dissertation]. McGill University; 1980. Available from: http://digitool.library.mcgill.ca/thesisfile68566.pdf

Boston College

19. Pal, Ayan. Synthesis Of Nucleoside Analogues: Glycosylation, Rigid Nucleosides And Janus Wedge Derivatives.

Degree: PhD, Chemistry, 2012, Boston College

URL: http://dlib.bc.edu/islandora/object/bc-ir:101522

► Nucleic Acids are unique biopolymers capable of encoding and transferring genetic information from one generation to the next for every form of life. This fascinating… (more)

Subjects/Keywords: Nucleic Acids; Nucleotides; Nucleotsides

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APA (6^th Edition):

Pal, A. (2012). Synthesis Of Nucleoside Analogues: Glycosylation, Rigid Nucleosides And Janus Wedge Derivatives. (Doctoral Dissertation). Boston College. Retrieved from http://dlib.bc.edu/islandora/object/bc-ir:101522

Chicago Manual of Style (16^th Edition):

Pal, Ayan. “Synthesis Of Nucleoside Analogues: Glycosylation, Rigid Nucleosides And Janus Wedge Derivatives.” 2012. Doctoral Dissertation, Boston College. Accessed February 21, 2020. http://dlib.bc.edu/islandora/object/bc-ir:101522.

MLA Handbook (7^th Edition):

Pal, Ayan. “Synthesis Of Nucleoside Analogues: Glycosylation, Rigid Nucleosides And Janus Wedge Derivatives.” 2012. Web. 21 Feb 2020.

Vancouver:

Pal A. Synthesis Of Nucleoside Analogues: Glycosylation, Rigid Nucleosides And Janus Wedge Derivatives. [Internet] [Doctoral dissertation]. Boston College; 2012. [cited 2020 Feb 21]. Available from: http://dlib.bc.edu/islandora/object/bc-ir:101522.

Council of Science Editors:

Pal A. Synthesis Of Nucleoside Analogues: Glycosylation, Rigid Nucleosides And Janus Wedge Derivatives. [Doctoral Dissertation]. Boston College; 2012. Available from: http://dlib.bc.edu/islandora/object/bc-ir:101522

University of Adelaide

20. Collins, Graham G. The effect of gibberellic acid on free nucleotide metabolism in aleurone cells of wheat / [by] Graham G. Collins.

Degree: 1970, University of Adelaide

URL: http://hdl.handle.net/2440/20708

Subjects/Keywords: Gibberellin.; Nucleotides.

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APA (6^th Edition):

Collins, G. G. (1970). The effect of gibberellic acid on free nucleotide metabolism in aleurone cells of wheat / [by] Graham G. Collins. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/20708

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Collins, Graham G. “The effect of gibberellic acid on free nucleotide metabolism in aleurone cells of wheat / [by] Graham G. Collins.” 1970. Thesis, University of Adelaide. Accessed February 21, 2020. http://hdl.handle.net/2440/20708.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Collins, Graham G. “The effect of gibberellic acid on free nucleotide metabolism in aleurone cells of wheat / [by] Graham G. Collins.” 1970. Web. 21 Feb 2020.

Vancouver:

Collins GG. The effect of gibberellic acid on free nucleotide metabolism in aleurone cells of wheat / [by] Graham G. Collins. [Internet] [Thesis]. University of Adelaide; 1970. [cited 2020 Feb 21]. Available from: http://hdl.handle.net/2440/20708.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Collins GG. The effect of gibberellic acid on free nucleotide metabolism in aleurone cells of wheat / [by] Graham G. Collins. [Thesis]. University of Adelaide; 1970. Available from: http://hdl.handle.net/2440/20708

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

21. Grivell, Anthony Robert. Thymidine nucleotide metabolism in Neurospora crassa and other organisms : problems of specific isotype labelling of DNA in fungi.

Degree: 1970, University of Adelaide

URL: http://hdl.handle.net/2440/20816

Subjects/Keywords: Thymidine.; Nucleotides.

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APA (6^th Edition):

Grivell, A. R. (1970). Thymidine nucleotide metabolism in Neurospora crassa and other organisms : problems of specific isotype labelling of DNA in fungi. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/20816

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Grivell, Anthony Robert. “Thymidine nucleotide metabolism in Neurospora crassa and other organisms : problems of specific isotype labelling of DNA in fungi.” 1970. Thesis, University of Adelaide. Accessed February 21, 2020. http://hdl.handle.net/2440/20816.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Grivell, Anthony Robert. “Thymidine nucleotide metabolism in Neurospora crassa and other organisms : problems of specific isotype labelling of DNA in fungi.” 1970. Web. 21 Feb 2020.

Vancouver:

Grivell AR. Thymidine nucleotide metabolism in Neurospora crassa and other organisms : problems of specific isotype labelling of DNA in fungi. [Internet] [Thesis]. University of Adelaide; 1970. [cited 2020 Feb 21]. Available from: http://hdl.handle.net/2440/20816.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Grivell AR. Thymidine nucleotide metabolism in Neurospora crassa and other organisms : problems of specific isotype labelling of DNA in fungi. [Thesis]. University of Adelaide; 1970. Available from: http://hdl.handle.net/2440/20816

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

22. Hicks, Allison, 1988-. Cell tropism predicts long-term nucleotide substitution rates of mammalian RNA viruses.

Degree: MS, Microbial Biology, 2013, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/41786/

► The high rates of RNA virus evolution are generally attributed to replication with error-prone RNA-dependent RNA polymerases. However, these long-term nucleotide substitution rates span three… (more)

▼ The high rates of RNA virus evolution are generally attributed to replication with error-prone RNA-dependent RNA polymerases. However, these long-term nucleotide substitution rates span three orders of magnitude and do not correlate well with mutation rates or selection pressures. This substitution rate variation may be explained by differences in virus ecology or intrinsic genomic properties. We generated long-term nucleotide substitution rate estimates for mammalian RNA viruses and compiled comparable published rates, yielding a dataset of 118 substitution rates of structural genes from 51 different species, as well as 40 rates of non-structural genes from 28 species. Through multiple regression analyses, we evaluated the relationships between these rates and four ecological factors: target cell, transmission route, host range, infection duration; and three genomic properties: genome length, genome sense, genome segmentation. Of these seven factors, we found target cells to be the only significant predictors of viral substitution rates, with tropisms for epithelial cells (P<2x10-5 for the structural genes) or neurons (P<3x10-7 and P<0.01 for the structural genes and non-structural genes, respectively) as the most significant predictors. Further, one-tailed t-tests showed that viruses primarily infecting epithelial cells evolve significantly faster than neurotropic viruses (P=1.83x10-10 and P=6.30x10-4 for the structural genes and non-structural genes, respectively). These results provide strong evidence that the fastest evolving mammalian RNA viruses infect cells with the highest turnover rates: the highly proliferative epithelial cells. Estimated viral generation times suggest that epithelial-infecting viruses replicate more quickly than viruses with different cell tropisms. Our results indicate that cell tropism is a key factor in viral evolvability. Advisors/Committee Members: Duffy, Siobain (chair), Hillman, Bradley (internal member), Kahn, Peter C. (internal member).

Subjects/Keywords: RNA viruses; Nucleotides; Mammals – Cytology

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APA (6^th Edition):

Hicks, Allison, 1. (2013). Cell tropism predicts long-term nucleotide substitution rates of mammalian RNA viruses. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/41786/

Chicago Manual of Style (16^th Edition):

Hicks, Allison, 1988-. “Cell tropism predicts long-term nucleotide substitution rates of mammalian RNA viruses.” 2013. Masters Thesis, Rutgers University. Accessed February 21, 2020. https://rucore.libraries.rutgers.edu/rutgers-lib/41786/.

MLA Handbook (7^th Edition):

Hicks, Allison, 1988-. “Cell tropism predicts long-term nucleotide substitution rates of mammalian RNA viruses.” 2013. Web. 21 Feb 2020.

Vancouver:

Hicks, Allison 1. Cell tropism predicts long-term nucleotide substitution rates of mammalian RNA viruses. [Internet] [Masters thesis]. Rutgers University; 2013. [cited 2020 Feb 21]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/41786/.

Council of Science Editors:

Hicks, Allison 1. Cell tropism predicts long-term nucleotide substitution rates of mammalian RNA viruses. [Masters Thesis]. Rutgers University; 2013. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/41786/

Michigan State University

23. Dannert, Robert Dale. The determination of 5'-mononucleotides in meats.

Degree: PhD, Department of Food Science, 1966, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:17702

Subjects/Keywords: Nucleotides; Meat

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APA (6^th Edition):

Dannert, R. D. (1966). The determination of 5'-mononucleotides in meats. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:17702

Chicago Manual of Style (16^th Edition):

Dannert, Robert Dale. “The determination of 5'-mononucleotides in meats.” 1966. Doctoral Dissertation, Michigan State University. Accessed February 21, 2020. http://etd.lib.msu.edu/islandora/object/etd:17702.

MLA Handbook (7^th Edition):

Dannert, Robert Dale. “The determination of 5'-mononucleotides in meats.” 1966. Web. 21 Feb 2020.

Vancouver:

Dannert RD. The determination of 5'-mononucleotides in meats. [Internet] [Doctoral dissertation]. Michigan State University; 1966. [cited 2020 Feb 21]. Available from: http://etd.lib.msu.edu/islandora/object/etd:17702.

Council of Science Editors:

Dannert RD. The determination of 5'-mononucleotides in meats. [Doctoral Dissertation]. Michigan State University; 1966. Available from: http://etd.lib.msu.edu/islandora/object/etd:17702

Michigan State University

24. Kroon, Daniel John, 1949-. Analogs of nicotinamide adenine dinucleotide as probes of the stereochemical relationships in the ternary complex of alcohol dehydrogenases.

Degree: PhD, 1976, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:34989

Subjects/Keywords: Nucleotides; Nucleotides – Metabolism; Dehydrogenases; Stereochemistry

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APA (6^th Edition):

Kroon, Daniel John, 1. (1976). Analogs of nicotinamide adenine dinucleotide as probes of the stereochemical relationships in the ternary complex of alcohol dehydrogenases. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:34989

Chicago Manual of Style (16^th Edition):

Kroon, Daniel John, 1949-. “Analogs of nicotinamide adenine dinucleotide as probes of the stereochemical relationships in the ternary complex of alcohol dehydrogenases.” 1976. Doctoral Dissertation, Michigan State University. Accessed February 21, 2020. http://etd.lib.msu.edu/islandora/object/etd:34989.

MLA Handbook (7^th Edition):

Kroon, Daniel John, 1949-. “Analogs of nicotinamide adenine dinucleotide as probes of the stereochemical relationships in the ternary complex of alcohol dehydrogenases.” 1976. Web. 21 Feb 2020.

Vancouver:

Kroon, Daniel John 1. Analogs of nicotinamide adenine dinucleotide as probes of the stereochemical relationships in the ternary complex of alcohol dehydrogenases. [Internet] [Doctoral dissertation]. Michigan State University; 1976. [cited 2020 Feb 21]. Available from: http://etd.lib.msu.edu/islandora/object/etd:34989.

Council of Science Editors:

Kroon, Daniel John 1. Analogs of nicotinamide adenine dinucleotide as probes of the stereochemical relationships in the ternary complex of alcohol dehydrogenases. [Doctoral Dissertation]. Michigan State University; 1976. Available from: http://etd.lib.msu.edu/islandora/object/etd:34989

The Ohio State University

25. Maynard, Donald Earle. Isolation and identification of the acid-soluble nucleosides and nucleotides of Penicillium charlesii.

Degree: PhD, Graduate School, 1961, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu148648377454148

Subjects/Keywords: Chemistry; Nucleosides; Nucleotides

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APA (6^th Edition):

Maynard, D. E. (1961). Isolation and identification of the acid-soluble nucleosides and nucleotides of Penicillium charlesii. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu148648377454148

Chicago Manual of Style (16^th Edition):

Maynard, Donald Earle. “Isolation and identification of the acid-soluble nucleosides and nucleotides of Penicillium charlesii.” 1961. Doctoral Dissertation, The Ohio State University. Accessed February 21, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu148648377454148.

MLA Handbook (7^th Edition):

Maynard, Donald Earle. “Isolation and identification of the acid-soluble nucleosides and nucleotides of Penicillium charlesii.” 1961. Web. 21 Feb 2020.

Vancouver:

Maynard DE. Isolation and identification of the acid-soluble nucleosides and nucleotides of Penicillium charlesii. [Internet] [Doctoral dissertation]. The Ohio State University; 1961. [cited 2020 Feb 21]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu148648377454148.

Council of Science Editors:

Maynard DE. Isolation and identification of the acid-soluble nucleosides and nucleotides of Penicillium charlesii. [Doctoral Dissertation]. The Ohio State University; 1961. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu148648377454148

The Ohio State University

26. Ambellan, Elisabeth Higgins. The effect of nucleotides on morphogenesis and ribonucleic acid synthesis in amphibian embryos.

Degree: PhD, Graduate School, 1961, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486483269984202

Subjects/Keywords: Biology; Nucleotides; Frogs

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APA (6^th Edition):

Ambellan, E. H. (1961). The effect of nucleotides on morphogenesis and ribonucleic acid synthesis in amphibian embryos. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1486483269984202

Chicago Manual of Style (16^th Edition):

Ambellan, Elisabeth Higgins. “The effect of nucleotides on morphogenesis and ribonucleic acid synthesis in amphibian embryos.” 1961. Doctoral Dissertation, The Ohio State University. Accessed February 21, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486483269984202.

MLA Handbook (7^th Edition):

Ambellan, Elisabeth Higgins. “The effect of nucleotides on morphogenesis and ribonucleic acid synthesis in amphibian embryos.” 1961. Web. 21 Feb 2020.

Vancouver:

Ambellan EH. The effect of nucleotides on morphogenesis and ribonucleic acid synthesis in amphibian embryos. [Internet] [Doctoral dissertation]. The Ohio State University; 1961. [cited 2020 Feb 21]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486483269984202.

Council of Science Editors:

Ambellan EH. The effect of nucleotides on morphogenesis and ribonucleic acid synthesis in amphibian embryos. [Doctoral Dissertation]. The Ohio State University; 1961. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486483269984202

The Ohio State University

27. Hu, Kuang Hung. Fluorescence properties of acriflavine-polynucleotide complexes.

Degree: PhD, Graduate School, 1967, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486641444916605

Subjects/Keywords: Chemistry; Nucleotides; Fluorescence

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APA (6^th Edition):

Hu, K. H. (1967). Fluorescence properties of acriflavine-polynucleotide complexes. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1486641444916605

Chicago Manual of Style (16^th Edition):

Hu, Kuang Hung. “Fluorescence properties of acriflavine-polynucleotide complexes.” 1967. Doctoral Dissertation, The Ohio State University. Accessed February 21, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486641444916605.

MLA Handbook (7^th Edition):

Hu, Kuang Hung. “Fluorescence properties of acriflavine-polynucleotide complexes.” 1967. Web. 21 Feb 2020.

Vancouver:

Hu KH. Fluorescence properties of acriflavine-polynucleotide complexes. [Internet] [Doctoral dissertation]. The Ohio State University; 1967. [cited 2020 Feb 21]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486641444916605.

Council of Science Editors:

Hu KH. Fluorescence properties of acriflavine-polynucleotide complexes. [Doctoral Dissertation]. The Ohio State University; 1967. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486641444916605

Dalhousie University

28. Beaton, Stephen A. Evaluation and Synthesis of Sugar 1-Phosphate Substrates for Nucleotidylyltransferases.

Degree: MS, Department of Chemistry, 2010, Dalhousie University

URL: http://hdl.handle.net/10222/12815

► The study of many of glycosyltransferases is limited due to an inadequate access to sugar nucleotides. Preparation of sugar nucleotides through the use of nucleotidylyltransferases… (more)

Subjects/Keywords: Nucleotidylyltransferases; organic synthesis; enzymes; sugar nucleotides

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APA (6^th Edition):

Beaton, S. A. (2010). Evaluation and Synthesis of Sugar 1-Phosphate Substrates for Nucleotidylyltransferases. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/12815

Chicago Manual of Style (16^th Edition):

Beaton, Stephen A. “Evaluation and Synthesis of Sugar 1-Phosphate Substrates for Nucleotidylyltransferases.” 2010. Masters Thesis, Dalhousie University. Accessed February 21, 2020. http://hdl.handle.net/10222/12815.

MLA Handbook (7^th Edition):

Beaton, Stephen A. “Evaluation and Synthesis of Sugar 1-Phosphate Substrates for Nucleotidylyltransferases.” 2010. Web. 21 Feb 2020.

Vancouver:

Beaton SA. Evaluation and Synthesis of Sugar 1-Phosphate Substrates for Nucleotidylyltransferases. [Internet] [Masters thesis]. Dalhousie University; 2010. [cited 2020 Feb 21]. Available from: http://hdl.handle.net/10222/12815.

Council of Science Editors:

Beaton SA. Evaluation and Synthesis of Sugar 1-Phosphate Substrates for Nucleotidylyltransferases. [Masters Thesis]. Dalhousie University; 2010. Available from: http://hdl.handle.net/10222/12815

University of Hong Kong

29. 羅永倫.; Law, Wing-lun. Expression, purification and preliminary x-ray crystallographic studies of two nucleotide binding proteins.

Degree: M. Phil., 2011, University of Hong Kong

URL: Law, W. [羅永倫]. (2011). Expression, purification and preliminary x-ray crystallographic studies of two nucleotide binding proteins. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4693911 ; http://dx.doi.org/10.5353/th_b4693911 ; http://hdl.handle.net/10722/144170

published_or_final_version

Physiology

Master

Master of Philosophy

Advisors/Committee Members: Kotaka, M, Tang, F, Hao, Q.

Subjects/Keywords: Carrier proteins.; Nucleotides.

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APA (6^th Edition):

羅永倫.; Law, W. (2011). Expression, purification and preliminary x-ray crystallographic studies of two nucleotide binding proteins. (Masters Thesis). University of Hong Kong. Retrieved from Law, W. [羅永倫]. (2011). Expression, purification and preliminary x-ray crystallographic studies of two nucleotide binding proteins. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4693911 ; http://dx.doi.org/10.5353/th_b4693911 ; http://hdl.handle.net/10722/144170

Chicago Manual of Style (16^th Edition):

羅永倫.; Law, Wing-lun. “Expression, purification and preliminary x-ray crystallographic studies of two nucleotide binding proteins.” 2011. Masters Thesis, University of Hong Kong. Accessed February 21, 2020. Law, W. [羅永倫]. (2011). Expression, purification and preliminary x-ray crystallographic studies of two nucleotide binding proteins. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4693911 ; http://dx.doi.org/10.5353/th_b4693911 ; http://hdl.handle.net/10722/144170.

MLA Handbook (7^th Edition):

羅永倫.; Law, Wing-lun. “Expression, purification and preliminary x-ray crystallographic studies of two nucleotide binding proteins.” 2011. Web. 21 Feb 2020.

Vancouver:

羅永倫.; Law W. Expression, purification and preliminary x-ray crystallographic studies of two nucleotide binding proteins. [Internet] [Masters thesis]. University of Hong Kong; 2011. [cited 2020 Feb 21]. Available from: Law, W. [羅永倫]. (2011). Expression, purification and preliminary x-ray crystallographic studies of two nucleotide binding proteins. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4693911 ; http://dx.doi.org/10.5353/th_b4693911 ; http://hdl.handle.net/10722/144170.

Council of Science Editors:

羅永倫.; Law W. Expression, purification and preliminary x-ray crystallographic studies of two nucleotide binding proteins. [Masters Thesis]. University of Hong Kong; 2011. Available from: Law, W. [羅永倫]. (2011). Expression, purification and preliminary x-ray crystallographic studies of two nucleotide binding proteins. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4693911 ; http://dx.doi.org/10.5353/th_b4693911 ; http://hdl.handle.net/10722/144170

Penn State University

30. Kehoe, Sylvia Inga. COLOSTRUM COMPONENTS AND THEIR IMPACT ON DIGESTIVE FUNCTION AND GROWTH OF DAIRY CALVES.

Degree: PhD, Animal Science, 2006, Penn State University

URL: https://etda.libraries.psu.edu/catalog/7379

► Colostrum is the first important step in raising healthy dairy calves. Feeding of adequate volumes of colostrum within the first 2 hours after birth improves… (more)

▼ Colostrum is the first important step in raising healthy dairy calves. Feeding of adequate volumes of colostrum within the first 2 hours after birth improves calf health, immunity and productive lifespan. Two experiments were conducted, the first was to evaluate and record colostrum management and nutrient composition to determine any improved or deleterious changes. The second was to evaluate the effects of a particular component of colostrum, nucleotides, on enhancing absorptive capacity and decreasing diarrhea in neonatal dairy calves. For the first experiment, data and samples were obtained from 55 farms around the state of Pennsylvania. Samples were analyzed for fat, protein, lactose, total solids, ash, immunoglobulins, lactoferrin, water- and fat-soluble vitamins and minerals. Results of means of fat, protein, lactose and lactoferrin were as follows: 6.7%, 14.92%, 2.49% and 0.82 mg/ml, respectively. Immunoglobulin G1, G2, A and M were 35.1 ± 11.9, 5.6 ± 1.9, 1.7 ± 0.9 and 4.3 ± 2.8 g/L, respectively. Fat-soluble vitamins included retinol, tocopherol and B-carotene and were 4.9, 2.92 and 0.68 ug/g, respectively. Means of water-soluble vitamins were 0.34, 0.90, 4.55, 0.60, 0.15, 0.21 and 0.04 for niacinamide, thiamine, riboflavin, cyanocobalamin, pyridoxal, pyridoxamine and pyridoxine, respectively. Means of minerals (mg/kg) consisted of calcium 4716.08; phosphorus 4452.12; magnesium 733.24; sodium 1058.93; potassium 2845.89; zinc 38.10; iron 5.33; copper 0.34 and manganese 0.10. In comparison to previous reviews of bovine colostrum, most nutrient levels have increased. Management practices have also improved in areas of colostrum storage and feeding. Calves were fed by bottle in 85% of farms and only 1 farm allowed calves to nurse the dam. Calves were fed first colostrum within 6 hours of birth in 95% of farms and 38% of farms had a supply of frozen colostrum readily available for use. For the second experiment, to analyze for effects of feeding purified or yeast derived nucleotides, calves were fed milk replacer at 10% of BW daily and treatments consisted of no nucleotide supplementation (C), purified nucleotide supplementation (N) and yeast supplementation (P; Alltech, Inc.). Growth, health, fecal dry matters and fecal bacteria were monitored and blood was analyzed for hematocrits, glucose, blood urea nitrogen and creatinine. After the second day of scouring, xylose (0.5 g/kg of BW) was administered orally once and blood was taken before administration for a baseline as well as 1, 2, 3 and 4 h post-dosing. Concentrations of plasma xylose increased with time post-dosing, but did not vary by treatment. Hematocrits were significantly higher for treatment N for weeks 2 and 5. Growth parameters and plasma concentrations of glucose, BUN, creatinine and IgG were not different between treatments. There were also no treatment effects on fecal dry matters and concentrations of fecal bacteria. Intestinal parameters, including morphology, enzyme activities, DNA and protein concentrations were not significantly affected by…

Subjects/Keywords: nucleotides; calves; colostrum

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APA (6^th Edition):

Kehoe, S. I. (2006). COLOSTRUM COMPONENTS AND THEIR IMPACT ON DIGESTIVE FUNCTION AND GROWTH OF DAIRY CALVES. (Doctoral Dissertation). Penn State University. Retrieved from https://etda.libraries.psu.edu/catalog/7379

Chicago Manual of Style (16^th Edition):

Kehoe, Sylvia Inga. “COLOSTRUM COMPONENTS AND THEIR IMPACT ON DIGESTIVE FUNCTION AND GROWTH OF DAIRY CALVES.” 2006. Doctoral Dissertation, Penn State University. Accessed February 21, 2020. https://etda.libraries.psu.edu/catalog/7379.

MLA Handbook (7^th Edition):

Kehoe, Sylvia Inga. “COLOSTRUM COMPONENTS AND THEIR IMPACT ON DIGESTIVE FUNCTION AND GROWTH OF DAIRY CALVES.” 2006. Web. 21 Feb 2020.

Vancouver:

Kehoe SI. COLOSTRUM COMPONENTS AND THEIR IMPACT ON DIGESTIVE FUNCTION AND GROWTH OF DAIRY CALVES. [Internet] [Doctoral dissertation]. Penn State University; 2006. [cited 2020 Feb 21]. Available from: https://etda.libraries.psu.edu/catalog/7379.

Council of Science Editors:

Kehoe SI. COLOSTRUM COMPONENTS AND THEIR IMPACT ON DIGESTIVE FUNCTION AND GROWTH OF DAIRY CALVES. [Doctoral Dissertation]. Penn State University; 2006. Available from: https://etda.libraries.psu.edu/catalog/7379

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