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McMaster University

1. Monster, Kathleen. Multiple Ingredient Dietary Supplement and Protective Effects in Gamma Irradiated Mice.

Degree: 2015, McMaster University

Cognitive impairment, “Chemofog”, has been well established as a negative outcome of otherwise successful medical radiation treatments. Mitigation of this negative feature would dramatically increase quality of life for those recovering from cancer treatment. There is currently no known intervention to protect or restore cognitive function of patients undergoing radiation treatments. Development of a multiple ingredient dietary supplement (MDS) is meant to offer a non-invasive therapy to help mitigate risk and decrease damage to individuals. The MDS was originally designed to off-set 5 key mechanisms associated with aging including oxidative damage, inflammation, impaired glucose metabolism, mitochondrial dysfunction and membrane deterioration. Radiation damage shares many of the same deficiencies that develop with age and supplementation with MDS would impact many of the same pathways. Changes in cytokine profile (inflammation markers), and biomarkers of behavioural functions, sensory functions, and oxidative damage provide preliminary evidence of MDS impacts.

Thesis

Bachelor of Science (BSc)

Cognitive impairment, “Chemofog”, has been well established as a negative outcome of otherwise successful medical radiation treatments. Mitigation of this negative feature would dramatically increase quality of life for those recovering from cancer treatment. There is currently no known intervention to protect or restore cognitive function of patients undergoing radiation treatments. Development of a multiple ingredient dietary supplement (MDS) is meant to offer a non-invasive therapy to help mitigate risk and decrease damage to individuals. The MDS was originally designed to off-set 5 key mechanisms associated with aging including oxidative damage, inflammation, impaired glucose metabolism, mitochondrial dysfunction and membrane deterioration. Radiation damage shares many of the same deficiencies that develop with age and supplementation with MDS would impact many of the same pathways.

Advisors/Committee Members: Rollo, C. David, Boreham, Douglas, Biology.

Subjects/Keywords: MDS; Radiation; Diet Supplement; Gamma; Protect; Mitigate; Olfaction; Behaviour; Novel Object Recognition; Novel Placement Recognition; Cytokines; DNA oxidation; Radiation Damage; Multiple Ingredient Dietary Supplement; Mice; C57Bl; Chemofog; Cognition

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Monster, K. (2015). Multiple Ingredient Dietary Supplement and Protective Effects in Gamma Irradiated Mice. (Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/18263

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Monster, Kathleen. “Multiple Ingredient Dietary Supplement and Protective Effects in Gamma Irradiated Mice.” 2015. Thesis, McMaster University. Accessed October 22, 2019. http://hdl.handle.net/11375/18263.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Monster, Kathleen. “Multiple Ingredient Dietary Supplement and Protective Effects in Gamma Irradiated Mice.” 2015. Web. 22 Oct 2019.

Vancouver:

Monster K. Multiple Ingredient Dietary Supplement and Protective Effects in Gamma Irradiated Mice. [Internet] [Thesis]. McMaster University; 2015. [cited 2019 Oct 22]. Available from: http://hdl.handle.net/11375/18263.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Monster K. Multiple Ingredient Dietary Supplement and Protective Effects in Gamma Irradiated Mice. [Thesis]. McMaster University; 2015. Available from: http://hdl.handle.net/11375/18263

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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