subject:(Neurons)

Boston College

1. Pell, Diana. Return Map of a Periodically Driven Neuron.

Degree: MA, Mathematics, 2011, Boston College

URL: http://dlib.bc.edu/islandora/object/bc-ir:101218

► A typical neuron receives input from more than 10,000 other neurons. These inputs each get processed differently, depending on the neuron's morphology, chemistry, etc. The… (more)

Subjects/Keywords: Neurons

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APA (6^th Edition):

Pell, D. (2011). Return Map of a Periodically Driven Neuron. (Masters Thesis). Boston College. Retrieved from http://dlib.bc.edu/islandora/object/bc-ir:101218

Chicago Manual of Style (16^th Edition):

Pell, Diana. “Return Map of a Periodically Driven Neuron.” 2011. Masters Thesis, Boston College. Accessed February 18, 2020. http://dlib.bc.edu/islandora/object/bc-ir:101218.

MLA Handbook (7^th Edition):

Pell, Diana. “Return Map of a Periodically Driven Neuron.” 2011. Web. 18 Feb 2020.

Vancouver:

Pell D. Return Map of a Periodically Driven Neuron. [Internet] [Masters thesis]. Boston College; 2011. [cited 2020 Feb 18]. Available from: http://dlib.bc.edu/islandora/object/bc-ir:101218.

Council of Science Editors:

Pell D. Return Map of a Periodically Driven Neuron. [Masters Thesis]. Boston College; 2011. Available from: http://dlib.bc.edu/islandora/object/bc-ir:101218

Rutgers University

2. O'Neill, Kate M., 1989-. The role of brain-derived neurotrophic factor in the regulation of dendritic arbor morphology, neuronal network activity, and neuroprotection.

Degree: PhD, Biomedical Engineering, 2017, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/53958/

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The dendritic architecture of a neuron determines how it receives inputs, and thus, changes in dendrite morphology will affect connectivity among neurons. Aberrant changes in… (more)

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The dendritic architecture of a neuron determines how it receives inputs, and thus, changes in dendrite morphology will affect connectivity among neurons. Aberrant changes in the development of the arbor, or after the arbor has formed, can disrupt the functioning of neural circuits, causing severe brain dysfunction and leading to pathologies seen in cognitive disorders, neurological diseases, and trauma. Brain-derived neurotrophic factor (BDNF) is one of the most well-studied regulators of dendritic and synaptic plasticity. It is also known to be a pro-survival factor and is overexpressed in neurons that survive injuries, such as ischemia. This dissertation explores how BDNF shapes the dendritic arbor of single hippocampal neurons and the dynamics of in vitro hippocampal networks. Previous work in our laboratory has shown that BDNF significantly increases proximal dendrite branching in hippocampal neurons after 72 hours of bath application. Building on this work, we show that local application of BDNF via microbeads increases both proximal and distal dendrite branching in a shorter time than does bath application. We also show that overexpression of BDNF shapes the dendritic arbor differently depending on the intracellular targeting of BDNF transcripts. To understand how BDNF affects the development of hippocampal neuronal networks, we use microelectrode arrays (MEAs) to record the spontaneous activity of these networks before and after bath application of BDNF. Our results suggest a role for BDNF in the long-term development of neuronal network dynamics, as changes in network parameters were only observed at one week after treatment. Finally, we explore whether BDNF exerts neuroprotective effects following excitotoxic injury. Global activity parameters decrease following injury with excess glutamate with no benefit from BDNF treatment, but BDNF does protect connections with distinct baseline synchronizations from injury-induced decreases. Taken together, our results indicate that BDNF is involved in the development of the dendritic arbor, the maturation of neuronal networks, and the protection of distinct connections after excitotoxic injury.

Advisors/Committee Members: Firestein, Bonnie L (chair), Shinbrot, Troy (internal member), Paradiso, Ken (internal member), Thakker-Varia, Smita (internal member), Morrison, III, Barclay (outside member).

Subjects/Keywords: Neurons

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APA (6^th Edition):

O'Neill, Kate M., 1. (2017). The role of brain-derived neurotrophic factor in the regulation of dendritic arbor morphology, neuronal network activity, and neuroprotection. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/53958/

Chicago Manual of Style (16^th Edition):

O'Neill, Kate M., 1989-. “The role of brain-derived neurotrophic factor in the regulation of dendritic arbor morphology, neuronal network activity, and neuroprotection.” 2017. Doctoral Dissertation, Rutgers University. Accessed February 18, 2020. https://rucore.libraries.rutgers.edu/rutgers-lib/53958/.

MLA Handbook (7^th Edition):

O'Neill, Kate M., 1989-. “The role of brain-derived neurotrophic factor in the regulation of dendritic arbor morphology, neuronal network activity, and neuroprotection.” 2017. Web. 18 Feb 2020.

Vancouver:

O'Neill, Kate M. 1. The role of brain-derived neurotrophic factor in the regulation of dendritic arbor morphology, neuronal network activity, and neuroprotection. [Internet] [Doctoral dissertation]. Rutgers University; 2017. [cited 2020 Feb 18]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/53958/.

Council of Science Editors:

O'Neill, Kate M. 1. The role of brain-derived neurotrophic factor in the regulation of dendritic arbor morphology, neuronal network activity, and neuroprotection. [Doctoral Dissertation]. Rutgers University; 2017. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/53958/

University of Alberta

3. Vincent, Steven J. The costs and benefits of large neuronal ensembles and high firing rates for the transmission of information in neuronal systems.

Degree: MS, Department of Physiology, 1990, University of Alberta

URL: https://era.library.ualberta.ca/files/4m90dx58c

Subjects/Keywords: Neurons.

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APA (6^th Edition):

Vincent, S. J. (1990). The costs and benefits of large neuronal ensembles and high firing rates for the transmission of information in neuronal systems. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/4m90dx58c

Chicago Manual of Style (16^th Edition):

Vincent, Steven J. “The costs and benefits of large neuronal ensembles and high firing rates for the transmission of information in neuronal systems.” 1990. Masters Thesis, University of Alberta. Accessed February 18, 2020. https://era.library.ualberta.ca/files/4m90dx58c.

MLA Handbook (7^th Edition):

Vincent, Steven J. “The costs and benefits of large neuronal ensembles and high firing rates for the transmission of information in neuronal systems.” 1990. Web. 18 Feb 2020.

Vancouver:

Vincent SJ. The costs and benefits of large neuronal ensembles and high firing rates for the transmission of information in neuronal systems. [Internet] [Masters thesis]. University of Alberta; 1990. [cited 2020 Feb 18]. Available from: https://era.library.ualberta.ca/files/4m90dx58c.

Council of Science Editors:

Vincent SJ. The costs and benefits of large neuronal ensembles and high firing rates for the transmission of information in neuronal systems. [Masters Thesis]. University of Alberta; 1990. Available from: https://era.library.ualberta.ca/files/4m90dx58c

University of Aberdeen

4. Woolley, David. The actions of a soft coral derived natural product on neurones.

Degree: 2008, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=24801 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493403

► The effects of a soft coral derived product and its major active component, 3-carboxyl-methylpyridinium (CMP), were assessed in cultured neurones from dorsal root ganglion (DRG)… (more)

Subjects/Keywords: 615.32; Neurons

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APA (6^th Edition):

Woolley, D. (2008). The actions of a soft coral derived natural product on neurones. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=24801 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493403

Chicago Manual of Style (16^th Edition):

Woolley, David. “The actions of a soft coral derived natural product on neurones.” 2008. Doctoral Dissertation, University of Aberdeen. Accessed February 18, 2020. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=24801 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493403.

MLA Handbook (7^th Edition):

Woolley, David. “The actions of a soft coral derived natural product on neurones.” 2008. Web. 18 Feb 2020.

Vancouver:

Woolley D. The actions of a soft coral derived natural product on neurones. [Internet] [Doctoral dissertation]. University of Aberdeen; 2008. [cited 2020 Feb 18]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=24801 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493403.

Council of Science Editors:

Woolley D. The actions of a soft coral derived natural product on neurones. [Doctoral Dissertation]. University of Aberdeen; 2008. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=24801 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493403

University of Aberdeen

5. Woolley, David. The actions of a soft coral derived natural product on neurones.

Degree: School of Medical Sciences, 2008, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=24801 ; http://digitool2.abdn.ac.uk:1801/webclient/DeliveryManager?pid=24801&custom_att_2=simple_viewer

Subjects/Keywords: Neurons

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Woolley, D. (2008). The actions of a soft coral derived natural product on neurones. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=24801 ; http://digitool2.abdn.ac.uk:1801/webclient/DeliveryManager?pid=24801&custom_att_2=simple_viewer

Chicago Manual of Style (16^th Edition):

Woolley, David. “The actions of a soft coral derived natural product on neurones.” 2008. Doctoral Dissertation, University of Aberdeen. Accessed February 18, 2020. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=24801 ; http://digitool2.abdn.ac.uk:1801/webclient/DeliveryManager?pid=24801&custom_att_2=simple_viewer.

MLA Handbook (7^th Edition):

Woolley, David. “The actions of a soft coral derived natural product on neurones.” 2008. Web. 18 Feb 2020.

Vancouver:

Woolley D. The actions of a soft coral derived natural product on neurones. [Internet] [Doctoral dissertation]. University of Aberdeen; 2008. [cited 2020 Feb 18]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=24801 ; http://digitool2.abdn.ac.uk:1801/webclient/DeliveryManager?pid=24801&custom_att_2=simple_viewer.

Council of Science Editors:

Woolley D. The actions of a soft coral derived natural product on neurones. [Doctoral Dissertation]. University of Aberdeen; 2008. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=24801 ; http://digitool2.abdn.ac.uk:1801/webclient/DeliveryManager?pid=24801&custom_att_2=simple_viewer

Rutgers University

6. Liu, Wenke, 1986-. Intrinsic and synaptic membrane responses of murine spiral ganglion neurons.

Degree: PhD, Neuroscience, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/48601/

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As the first neuronal element in the auditory pathway, spiral ganglion neurons are responsible for the initial signal encoding of complex sound information. Experiments presented… (more)

Subjects/Keywords: Neurons; Synapses

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APA (6^th Edition):

Liu, Wenke, 1. (2015). Intrinsic and synaptic membrane responses of murine spiral ganglion neurons. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/48601/

Chicago Manual of Style (16^th Edition):

Liu, Wenke, 1986-. “Intrinsic and synaptic membrane responses of murine spiral ganglion neurons.” 2015. Doctoral Dissertation, Rutgers University. Accessed February 18, 2020. https://rucore.libraries.rutgers.edu/rutgers-lib/48601/.

MLA Handbook (7^th Edition):

Liu, Wenke, 1986-. “Intrinsic and synaptic membrane responses of murine spiral ganglion neurons.” 2015. Web. 18 Feb 2020.

Vancouver:

Liu, Wenke 1. Intrinsic and synaptic membrane responses of murine spiral ganglion neurons. [Internet] [Doctoral dissertation]. Rutgers University; 2015. [cited 2020 Feb 18]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48601/.

Council of Science Editors:

Liu, Wenke 1. Intrinsic and synaptic membrane responses of murine spiral ganglion neurons. [Doctoral Dissertation]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48601/

Rutgers University

7. Coffey, Kevin. Both the direct (Drd1) and indirect (Drd2) pathways contain type IIb neurons whose firing rates are related to stimulation of individual body parts.

Degree: PhD, Psychology, 2016, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/51252/

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The dorsolateral striatum (DLS) is a prominent target of research on control of voluntary movement and sensorimotor integration. The DLS is comprised mainly (95%) of… (more)

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The dorsolateral striatum (DLS) is a prominent target of research on control of voluntary movement and sensorimotor integration. The DLS is comprised mainly (95%) of medium spiny projection neurons that receive direct monosynaptic projections from primary somatosensory (S1) and motor (M1) cortices. Roughly 50% of these neurons are type IIb GABAergic, medium spiny projection neurons (MSNs) whose firing rates (FRs) are related to sensorimotor activity of individual body parts. There is also a hypothesized dual organization of DLS outputs known as the â€œdirect and indirect pathwaysâ€. According to this model, direct pathway MSNs project to the substantia nigra pars reticulata (SNr) and the internal segment of the globus pallidus (GPi), leading to disinhibition of the thalamus and facilitation of movement. Conversely the indirect pathway projects to the SNr via the globus pallidus external segment (GPe) and then the subthalamic nucleus (STN), inhibiting the thalamus and reducing movement. In addition to their distinct projections, MSNs of the direct and indirect pathway are characterized by differential expression of dopamine receptors. Dopamine Drd1 is expressed by direct pathway MSNs, whereas Drd2 is expressed by indirect pathway MSNs. While there has been a significant amount of research testing the functional hypotheses generated by iii the direct and indirect pathways framework, no study has attempted to reconcile the very well classified striatal type IIb neurons with the aforementioned functional tenet of the hypothesis. The present study utilized AAV-EF1a-FLEx-Chronos-GFP to visualize and optogenetically identify Drd1 and Drd2 MSNs in Cre-animals. We then performed somatosensory motor exams in order to identify type IIb MSNs and fill the gap in the literature. We found that in Drd1-Cre animals, Chronos-GFP expressing neurons projected to GPi, while in Drd2-Cre animals, Chronos-GFP expressing neurons projected to GPe, providing evidence that Drd1-Cre and Drd2-Cre animals are valid models of the direct and indirect pathways. Further, we were able to unambiguously identify Drd1 and Drd2 MSNs in the striatum of awake, behaving mice using light stimulation. We were subsequently able show that both the direct (Drd1) and indirect (Drd2) pathways contain type IIb neurons with firing related to stimulation of body parts. This evidence brings into question the notion that Drd1 neurons promote movement, while Drd2 neurons inhibit it. Rather, it seems that Drd1 and Drd2 neurons process sensorimotor information similarly, with both Drd1 and Drd2 neurons exhibiting increased phasic firing during body part stimulation and movement. While the anatomical aspects of the direct and indirect pathways hypothesis are strongly corroborated, the functional aspect appears to need a critical reevaluation.

Advisors/Committee Members: West, Mark O (chair), Kusnecov, Alex (internal member), Wagner, George (internal member), Margolis, David (outside member).

Subjects/Keywords: Optogenetics; Neurons

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APA (6^th Edition):

Coffey, K. (2016). Both the direct (Drd1) and indirect (Drd2) pathways contain type IIb neurons whose firing rates are related to stimulation of individual body parts. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/51252/

Chicago Manual of Style (16^th Edition):

Coffey, Kevin. “Both the direct (Drd1) and indirect (Drd2) pathways contain type IIb neurons whose firing rates are related to stimulation of individual body parts.” 2016. Doctoral Dissertation, Rutgers University. Accessed February 18, 2020. https://rucore.libraries.rutgers.edu/rutgers-lib/51252/.

MLA Handbook (7^th Edition):

Coffey, Kevin. “Both the direct (Drd1) and indirect (Drd2) pathways contain type IIb neurons whose firing rates are related to stimulation of individual body parts.” 2016. Web. 18 Feb 2020.

Vancouver:

Coffey K. Both the direct (Drd1) and indirect (Drd2) pathways contain type IIb neurons whose firing rates are related to stimulation of individual body parts. [Internet] [Doctoral dissertation]. Rutgers University; 2016. [cited 2020 Feb 18]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/51252/.

Council of Science Editors:

Coffey K. Both the direct (Drd1) and indirect (Drd2) pathways contain type IIb neurons whose firing rates are related to stimulation of individual body parts. [Doctoral Dissertation]. Rutgers University; 2016. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/51252/

8. Moubarak, Estelle. Constraints imposed by morphological and biophysical properties of axon and dendrites on the electrical behaviour of rat substantia nigra pars compacta dopaminergic neurons : Contraintes imposées par les propriétés morphologiques et biophysiques de l'axone et des dendrites sur l'activité électrique des neurones dopaminergiques de la substance noire compacte de rat.

Degree: Docteur es, Neurosciences, 2018, Aix Marseille Université

URL: http://www.theses.fr/2018AIXM0746

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L’activité électrique des neurones est déterminée par des interactions complexes entre leurs propriétés morphologiques et biophysiques. Les neurones dopaminergiques (DA) de la substance noire compacte… (more)

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L’activité électrique des neurones est déterminée par des interactions complexes entre leurs propriétés morphologiques et biophysiques. Les neurones dopaminergiques (DA) de la substance noire compacte (SNc) présentent une caractéristique morphologique peu commune parmi les neurones de mammifères: leur axone émerge fréquemment d’une dendrite à une distance très variable du soma. Malgré cette importante variabilité dans la localisation de l’axone, peu d’articles ont étudié un lien potentiel entre morphologie neuronale et activité électrique dans ces cellules. Dans un premier article, nous avons exploré l’importante variabilité observée dans les neurones DA en caractérisant de nombreux paramètres morphologiques et biophysiques. Nos résultats suggèrent que la géométrie de l’AIS n’affecte pas significativement la forme du potentiel d’action ni l’activité pacemaker. En revanche, l’activité électrique est influencée par la morphologie et les conductances somatodendritiques. Dans une seconde étude, nous avons caractérisé le développement morphologique des neurones DA au cours des trois premières semaines post-natales. Nous avons observé une croissance asymétrique de l’arbre dendritique: la dendrite portant l’axone semble se complexifier plus que les autres dendrites. Cette asymétrie est associée à une contribution différente de la dendrite portant l’axone et des dendrites ne portant pas l’axone à la forme du potentiel d’action. Ces résultats suggèrent que les neurones DA de la SNc sont robustes aux variations morphologiques de l’axone et que les particularités morphologiques et biophysiques de leur arbre dendritique minimisent l’influence de l’AIS sur leur activité électrique.

Neuronal output is defined by the complex interplay between the biophysical and morphological properties of neurons. Dopaminergic (DA) neurons of the substantia nigra pars compacta (SNc) are spontaneously active and generate a regular pacemaking activity. While most mammalian neurons have an axon emerging from the soma, the axon of DA neurons often arises from a dendrite at highly variable distances from the soma. Despite this large cell-to-cell variation in axon location, few studies have tried to unravel the potential link between neuronal morphology and electrical behaviour in this cell type. In a first article, we explored the high degree of cell-to-cell variability found in DA neurons by characterising several morphological and biophysical parameters. While AIS geometry did not seem to significantly affect action potential shape or pacemaking activity, we found that the electrical behaviour of DA neurons was particularly sensitive to somatodendritic morphology and conductances. In a second study, we characterised the morphological development of DA neurons during the first three post-natal weeks. We observed an asymmetric development of the dendritic tree, favouring the elongation and complexity of the axon-bearing dendrite. This asymmetry is associated with different contributions of the axon-bearing and non-axon bearing dendrites to action…

Advisors/Committee Members: Goaillard, Jean-Marc (thesis director).

Subjects/Keywords: Neurones; Neurons

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APA (6^th Edition):

Moubarak, E. (2018). Constraints imposed by morphological and biophysical properties of axon and dendrites on the electrical behaviour of rat substantia nigra pars compacta dopaminergic neurons : Contraintes imposées par les propriétés morphologiques et biophysiques de l'axone et des dendrites sur l'activité électrique des neurones dopaminergiques de la substance noire compacte de rat. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2018AIXM0746

Chicago Manual of Style (16^th Edition):

Moubarak, Estelle. “Constraints imposed by morphological and biophysical properties of axon and dendrites on the electrical behaviour of rat substantia nigra pars compacta dopaminergic neurons : Contraintes imposées par les propriétés morphologiques et biophysiques de l'axone et des dendrites sur l'activité électrique des neurones dopaminergiques de la substance noire compacte de rat.” 2018. Doctoral Dissertation, Aix Marseille Université. Accessed February 18, 2020. http://www.theses.fr/2018AIXM0746.

MLA Handbook (7^th Edition):

Moubarak, Estelle. “Constraints imposed by morphological and biophysical properties of axon and dendrites on the electrical behaviour of rat substantia nigra pars compacta dopaminergic neurons : Contraintes imposées par les propriétés morphologiques et biophysiques de l'axone et des dendrites sur l'activité électrique des neurones dopaminergiques de la substance noire compacte de rat.” 2018. Web. 18 Feb 2020.

Vancouver:

Moubarak E. Constraints imposed by morphological and biophysical properties of axon and dendrites on the electrical behaviour of rat substantia nigra pars compacta dopaminergic neurons : Contraintes imposées par les propriétés morphologiques et biophysiques de l'axone et des dendrites sur l'activité électrique des neurones dopaminergiques de la substance noire compacte de rat. [Internet] [Doctoral dissertation]. Aix Marseille Université 2018. [cited 2020 Feb 18]. Available from: http://www.theses.fr/2018AIXM0746.

Council of Science Editors:

Moubarak E. Constraints imposed by morphological and biophysical properties of axon and dendrites on the electrical behaviour of rat substantia nigra pars compacta dopaminergic neurons : Contraintes imposées par les propriétés morphologiques et biophysiques de l'axone et des dendrites sur l'activité électrique des neurones dopaminergiques de la substance noire compacte de rat. [Doctoral Dissertation]. Aix Marseille Université 2018. Available from: http://www.theses.fr/2018AIXM0746

Oregon State University

9. Jacobs, Dakota. Effect of PFAS Exposure on Reproduction : a Comparative Investigation between Kisspeptin-secreting AVPV and Arcuate Nuclei.

Degree: MS, Toxicology, 2016, Oregon State University

URL: http://hdl.handle.net/1957/59888

► Ovulation requires preovulatory surges of gonadotropin-releasing hormone (GnRH) from preoptic hypothalamic neurons, initiated by elevated ovarian estradiol (E₂). Rising estradiol activates a subset of sexually… (more)

▼ Ovulation requires preovulatory surges of gonadotropin-releasing hormone (GnRH) from preoptic hypothalamic neurons, initiated by elevated ovarian estradiol (E₂). Rising estradiol activates a subset of sexually dimorphic kisspeptin (Kiss-1) neurons in the female, located in the anteroventral periventricular nuclei (AVPV). Conversely, estradiol negative feedback on GnRH secretion is mediated by a neuroanatomically separate population of Kiss-1 neurons in the arcuate nuclei. Kisspeptin stimulates GnRH expression and secretion in vivo, and the development of this system is critical for the initiation of puberty. To elucidate how phenotypically similar Kiss-1 neuronal populations react differentially to estradiol exposure, we have generated two immortalized Kiss-1 cell lines from kiss1-GFP post-pubertal female mice. These cell models recapitulate in vivo differential responsiveness to estradiol, with KTaV-3 (AVPV-derived) demonstrating ~6-fold increases in kiss1 expression under higher estradiol doses (5pM – 50pM E₂), while kiss1 expression in KTaR-1 cells is suppressed up to 80% under lower E2 concentrations (2pM – 10pM). We probed temporal patterns of kiss1 and core clock gene expression in these lines in response to estradiol, and found distinct antiphasic patterns of bmal1 and per2 in KTaV-3 cells irrespective of estradiol exposure. Treatment of KTaV-3 cells with 25pM E₂, however, elicited distinct patterns of kiss1 expression over time in contrast to vehicle, suggesting differential coupling of intracellular oscillators to kiss1 transcriptional activity in the presence of estradiol. Further, we have found that expression alterations between nuclear receptor ERα and ERβ genes, esr1 and esr2, respectively, fluctuate divergently between these lines. We have implicated that the peaks of kiss1 expression demonstrated by the KTaV-3 lines may be mediated by both classical and non-classical estrogen signaling. In addition, we provide evidence that the negative regulation of kiss1 expression in KTaR-1 cells may be a function of mutual antagonism due to overabundance of contemporaneously expressed esr1 and esr2 genes that is not observed in KTaV-3 lines. Lastly, we explored the impact of an endocrine disrupting class of perfluorinated alkyl substances (PFASs) on these neurons, with preliminary results illustrating kiss1, esr1, and esr2 transcriptional activation and/or repression at relevant doses of perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), and perfluorohexanoic acid (PFHxA) in the two lines. At extremely low doses of PFOA, typical estrogenic demonstrations of kiss1 expression are presented by KTaV-3 and KTaR-1 neurons. However at the same dose of PFOS the expression modulation of kiss1 gated by estrogen signaling in this hypothalamic populations is flipped. This implicates that a sufficient exposure to these ubiquitous chemicals can have a potent effect on neuronal expression profiles for estrogen sensitive genes that is a complex function of dose, particular PFAS, and tissue type. Ongoing… Advisors/Committee Members: Chappell, Patrick (advisor), Buermeyer, Andrew (committee member).

Subjects/Keywords: Kisspeptin; Kisspeptin neurons

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APA (6^th Edition):

Jacobs, D. (2016). Effect of PFAS Exposure on Reproduction : a Comparative Investigation between Kisspeptin-secreting AVPV and Arcuate Nuclei. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/59888

Chicago Manual of Style (16^th Edition):

Jacobs, Dakota. “Effect of PFAS Exposure on Reproduction : a Comparative Investigation between Kisspeptin-secreting AVPV and Arcuate Nuclei.” 2016. Masters Thesis, Oregon State University. Accessed February 18, 2020. http://hdl.handle.net/1957/59888.

MLA Handbook (7^th Edition):

Jacobs, Dakota. “Effect of PFAS Exposure on Reproduction : a Comparative Investigation between Kisspeptin-secreting AVPV and Arcuate Nuclei.” 2016. Web. 18 Feb 2020.

Vancouver:

Jacobs D. Effect of PFAS Exposure on Reproduction : a Comparative Investigation between Kisspeptin-secreting AVPV and Arcuate Nuclei. [Internet] [Masters thesis]. Oregon State University; 2016. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/1957/59888.

Council of Science Editors:

Jacobs D. Effect of PFAS Exposure on Reproduction : a Comparative Investigation between Kisspeptin-secreting AVPV and Arcuate Nuclei. [Masters Thesis]. Oregon State University; 2016. Available from: http://hdl.handle.net/1957/59888

Drexel University

10. Henderson, Max. The Effects of Aging on Neural Processes and Microcolumnar Networks.

Degree: 2015, Drexel University

URL: http://hdl.handle.net/1860/idea:7240

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Many areas of the human brain show intrinsic geometric order. This research focuses on particular substructures called microcolumns, which are vertically oriented clusters of neurons… (more)

Subjects/Keywords: Aging; Neurons; Physics

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APA (6^th Edition):

Henderson, M. (2015). The Effects of Aging on Neural Processes and Microcolumnar Networks. (Thesis). Drexel University. Retrieved from http://hdl.handle.net/1860/idea:7240

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Henderson, Max. “The Effects of Aging on Neural Processes and Microcolumnar Networks.” 2015. Thesis, Drexel University. Accessed February 18, 2020. http://hdl.handle.net/1860/idea:7240.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Henderson, Max. “The Effects of Aging on Neural Processes and Microcolumnar Networks.” 2015. Web. 18 Feb 2020.

Vancouver:

Henderson M. The Effects of Aging on Neural Processes and Microcolumnar Networks. [Internet] [Thesis]. Drexel University; 2015. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/1860/idea:7240.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Henderson M. The Effects of Aging on Neural Processes and Microcolumnar Networks. [Thesis]. Drexel University; 2015. Available from: http://hdl.handle.net/1860/idea:7240

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Columbia University

11. Glenwinkel, Lori Ann. In silico prediction of regulators of neuronal identity through phylogenetic footprinting.

Degree: 2018, Columbia University

URL: https://doi.org/10.7916/D8ZW33SC

► How individual neurons in a nervous system give rise to complex function, behavior and consciousness in higher animals has been studied for over a century,… (more)

Subjects/Keywords: Biometry; Phylogeny; Neurons

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APA (6^th Edition):

Glenwinkel, L. A. (2018). In silico prediction of regulators of neuronal identity through phylogenetic footprinting. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8ZW33SC

Chicago Manual of Style (16^th Edition):

Glenwinkel, Lori Ann. “In silico prediction of regulators of neuronal identity through phylogenetic footprinting.” 2018. Doctoral Dissertation, Columbia University. Accessed February 18, 2020. https://doi.org/10.7916/D8ZW33SC.

MLA Handbook (7^th Edition):

Glenwinkel, Lori Ann. “In silico prediction of regulators of neuronal identity through phylogenetic footprinting.” 2018. Web. 18 Feb 2020.

Vancouver:

Glenwinkel LA. In silico prediction of regulators of neuronal identity through phylogenetic footprinting. [Internet] [Doctoral dissertation]. Columbia University; 2018. [cited 2020 Feb 18]. Available from: https://doi.org/10.7916/D8ZW33SC.

Council of Science Editors:

Glenwinkel LA. In silico prediction of regulators of neuronal identity through phylogenetic footprinting. [Doctoral Dissertation]. Columbia University; 2018. Available from: https://doi.org/10.7916/D8ZW33SC

12. Gilmore, Ian Richard. Quantitative proteomic analysis of the effect of 24(S),25-epoxycholesterol on SN4741 neuron cells.

Degree: PhD, 2013, Swansea University

URL: https://cronfa.swan.ac.uk/Record/cronfa42712 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678489

► Oxysterols are oxygenated derivatives of cholesterol or its precursors. One oxysterol, 24(S),25-epoxycholesterol (24(S),25-EC), which results from a shunt in the cholesterol synthesis pathway has been… (more)

▼ Oxysterols are oxygenated derivatives of cholesterol or its precursors. One oxysterol, 24(S),25-epoxycholesterol (24(S),25-EC), which results from a shunt in the cholesterol synthesis pathway has been found at higher than expected levels in embryonic murine brain. Interestingly, the receptor that 24(5),25-EC is a ligand for, Liver X Receptor (LXR), has been implicated in neurogenesis in the ventral mid brain region of embryonic brain; an area with a high density of dopaminergic neurons. The mechanism by which LXR induces this effect is unclear. Therefore, proteomic and phosphoproteomic studies were performed using a stable isotope labelled in amino acid in cell culture (SILAC) approach in order to quantify changes in the proteome between different treatment groups in a mouse substantia nigra dopaminergic cell line (SN4741) SN4741 cells were cultured in SILAC media containing differentially isotope labelled arginine and lysine. For protein expression studies SN4741 cells were treated in serum free media with vehicle, 10muM 24(S),25-EC, or 1muM GW3965, a synthetic ligand of LXR, for 24 hours. For analysis of changes in the phosphoproteome SN4741 cells were treated in serum free media with vehicle, 10muM 24(5),25-EC, or 30muM 25- hydroxycholesterol for 6 hours. Cells were lysed and protein combined in a 1:1 ratio before trypsin digestion and peptide separation via strong cation exchange chromatography. Phosphopeptides were enriched using immobilised metal affinity chromatography (IMAC). Resulting fractions were analysed, using a data dependent LC-MS/MS method. Data was quantified using MaxQuant software in conjunction with Mascot using an IPl mouse database. In protein expression analysis known oxysterol regulated genes, via SREBP or LXR, were differentially expressed. Oxysterol treatment induced global changes in proteins involved in lipid (cholesterol, fatty acid, phospholipid, triglyceride) synthesis. LXR? protein expression increased after GW3965 and 24(5),25-EC treatment, though no change was seen on LXRp mRNA, implying that ligand binding protects LXR? from degradation. 24(S),25-EC induced changes in expression and localisation of the membrane protein caveolin-1. Also, phosphoethanolamine cytidylyltransferase and collagen type IV alpha-3-binding protein, 2 proteins involved in phospholipid synthesis, had an altered expression after 24(S),25-EC treatment suggesting a role for oxysterols in membrane homeostasis. A cytokine, macrophage colony stimulating factor, which is required for normal neuronal development and macrophage differentiation had an LXR independent increased expression after 24(S),25-EC treatment. Quantitative RT-PCR data demonstrated that proteomic changes were due to both transcriptional and post-transcriptional effects of oxysterol. In addition, studies examining changes in the mouse phosphoproteome identified a number of novel phosphorylation sites.

Subjects/Keywords: 573.8; Proteomics; Neurons

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APA (6^th Edition):

Gilmore, I. R. (2013). Quantitative proteomic analysis of the effect of 24(S),25-epoxycholesterol on SN4741 neuron cells. (Doctoral Dissertation). Swansea University. Retrieved from https://cronfa.swan.ac.uk/Record/cronfa42712 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678489

Chicago Manual of Style (16^th Edition):

Gilmore, Ian Richard. “Quantitative proteomic analysis of the effect of 24(S),25-epoxycholesterol on SN4741 neuron cells.” 2013. Doctoral Dissertation, Swansea University. Accessed February 18, 2020. https://cronfa.swan.ac.uk/Record/cronfa42712 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678489.

MLA Handbook (7^th Edition):

Gilmore, Ian Richard. “Quantitative proteomic analysis of the effect of 24(S),25-epoxycholesterol on SN4741 neuron cells.” 2013. Web. 18 Feb 2020.

Vancouver:

Gilmore IR. Quantitative proteomic analysis of the effect of 24(S),25-epoxycholesterol on SN4741 neuron cells. [Internet] [Doctoral dissertation]. Swansea University; 2013. [cited 2020 Feb 18]. Available from: https://cronfa.swan.ac.uk/Record/cronfa42712 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678489.

Council of Science Editors:

Gilmore IR. Quantitative proteomic analysis of the effect of 24(S),25-epoxycholesterol on SN4741 neuron cells. [Doctoral Dissertation]. Swansea University; 2013. Available from: https://cronfa.swan.ac.uk/Record/cronfa42712 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678489

Rutgers University

13. Hamod, Aula, 1982-. Purifications of small molecules that regulate neuronal cell-lineage specification.

Degree: MS, Physiology and Integrative Biology, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/48504/

► There are certain important factors that are essential for specification, development and maintenance vertebrate nervous system. During development these factors regulate axonal growth, dendrite pruning,… (more)

Subjects/Keywords: Nervous system; Neurons

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APA (6^th Edition):

Hamod, Aula, 1. (2015). Purifications of small molecules that regulate neuronal cell-lineage specification. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/48504/

Chicago Manual of Style (16^th Edition):

Hamod, Aula, 1982-. “Purifications of small molecules that regulate neuronal cell-lineage specification.” 2015. Masters Thesis, Rutgers University. Accessed February 18, 2020. https://rucore.libraries.rutgers.edu/rutgers-lib/48504/.

MLA Handbook (7^th Edition):

Hamod, Aula, 1982-. “Purifications of small molecules that regulate neuronal cell-lineage specification.” 2015. Web. 18 Feb 2020.

Vancouver:

Hamod, Aula 1. Purifications of small molecules that regulate neuronal cell-lineage specification. [Internet] [Masters thesis]. Rutgers University; 2015. [cited 2020 Feb 18]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48504/.

Council of Science Editors:

Hamod, Aula 1. Purifications of small molecules that regulate neuronal cell-lineage specification. [Masters Thesis]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48504/

Rutgers University

14. Ünal, Bengi, 1982-. Tyrosine hydroxylase-expressing interneurons in intact and dopamine-depleted striatum.

Degree: PhD, Behavioral and Neural Sciences, 2012, Rutgers University

URL: http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000066590

►

Tyrosine hydroxylase-expressing (TH+) interneurons of the striatum stand in a critical point for our understanding of the interaction between striatal dopamine and striatal interneurons. Recent… (more)

▼

Tyrosine hydroxylase-expressing (TH+) interneurons of the striatum stand in a critical point for our understanding of the interaction between striatal dopamine and striatal interneurons. Recent investigations from our laboratory have established that TH+ neurons comprise an electrophysiologically distinct group striatal GABAergic interneurons by using transgenic mice expressing enhanced green fluorescent protein under the control TH promoter (TH-eGFP). In order to understand the significance of striatal TH+ neurons in the normal and dopamine-depleted striatum, determining anatomical distribution of TH+ neurons with regard to their electrophysiological diversity and striatal anatomical heterogeneity was imperative. In the first part of my thesis, I investigated striatal localization of TH-eGFP neurons with respect to anatomical organization of the striatum. In the second set of experiments, I investigated the changes in anatomical distribution, morphology, and electrophysiology of TH-eGFP neurons following striatal dopamine-depletion. Data presented here indicates that the electrophysiological subtypes of TH-eGFP interneurons are equally prevalent throughout striatum. However, when patch/striosome-matrix organization is taken into account, a different pattern emerges in the dorso-ventral axis of the striatum: a significantly higher proportion of striatal TH-eGFP interneurons were located in MOR-enriched domains of the ventral striatum. Finally, TH-eGFP interneurons in both compartments extended their neurites into the neighboring compartment. In the second set of experiments, I investigated the effect of striatal dopamine loss achieved by unilateral intranigral 6-OHDA infusion on TH-eGFP interneuron anatomy and physiology. The data presented here show that dopamine loss has a temporally and regionally different effect on the number of striatal TH-eGFP interneurons. Several electrophysiological parameters of TH-eGFP interneurons show profound changes in dopamine-depleted striatum, such as reduction in plateau potentials and increase in spontaneous synaptic inputs, which were accompanied by a significant increase in spine density on these neurons. Taken together, the findings in this thesis establish that TH-eGFP neurons are a distinct group of striatal interneurons that show differential anatomical patterning throughout the dorsal-ventral axis of the striatum and respond to striatal dopamine-loss in a qualitatively and quantitatively different manner than striatal projection neurons.

Advisors/Committee Members: Ünal, Bengi, 1982- (author), Abercrombie, Elizabeth D (chair), Tepper, James M (internal member), Jonakait, G Miller (internal member), Zaborszky, Laszlo (internal member), Smith, Yoland (outside member).

Subjects/Keywords: Interneurons; Dopaminergic neurons

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APA (6^th Edition):

Ünal, Bengi, 1. (2012). Tyrosine hydroxylase-expressing interneurons in intact and dopamine-depleted striatum. (Doctoral Dissertation). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000066590

Chicago Manual of Style (16^th Edition):

Ünal, Bengi, 1982-. “Tyrosine hydroxylase-expressing interneurons in intact and dopamine-depleted striatum.” 2012. Doctoral Dissertation, Rutgers University. Accessed February 18, 2020. http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000066590.

MLA Handbook (7^th Edition):

Ünal, Bengi, 1982-. “Tyrosine hydroxylase-expressing interneurons in intact and dopamine-depleted striatum.” 2012. Web. 18 Feb 2020.

Vancouver:

Ünal, Bengi 1. Tyrosine hydroxylase-expressing interneurons in intact and dopamine-depleted striatum. [Internet] [Doctoral dissertation]. Rutgers University; 2012. [cited 2020 Feb 18]. Available from: http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000066590.

Council of Science Editors:

Ünal, Bengi 1. Tyrosine hydroxylase-expressing interneurons in intact and dopamine-depleted striatum. [Doctoral Dissertation]. Rutgers University; 2012. Available from: http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000066590

University College Cork

15. McKelvey, Laura. The role of glucocorticoid-induced tumour necrosis factor receptor in developing mouse sympathetic neurons.

Degree: 2013, University College Cork

URL: http://hdl.handle.net/10468/1291

► Hereditary sensory autonomic neuropathy IV (HSAN IV) is an autosomal recessive disorder characterised by inability to feel pain and anhidrosis and is a consequence of… (more)

▼ Hereditary sensory autonomic neuropathy IV (HSAN IV) is an autosomal recessive disorder characterised by inability to feel pain and anhidrosis and is a consequence of defective NGF/TrkA signalling and growth of sensory and sympathetic neurons. Glucocortiocoid-induced tumour necrosis factors receptor (GITR), a transmembrane protein, activated by its specific ligand, GITRL, is well known for its role in the regulation of innate and acquired immune system responses. Recently, GITR was found to be required for NGF-dependant and extracellular signal-related kinase 1/2 (ERK1/2)-induced neurite growth and target innervation in the developing sympathetic nervous system (SNS). Given this novel role of GITR, it is possible that strategies targeting GITR have potential therapeutic benefit in promoting neurite growth in autonomic neuropathies such as HSAN IV. Using P1 mouse SCG neurons as a model, in addition to various SCG cell treatments, knock down models and transfection methods, we investigated whether GITR increases the sensitivity of sympathetic neurons to NGF; the region of GITR required for the enhancement of NGF-promoted growth, the signalling pathways downstream of GITR and how extensively GITR is involved in regulating peripheral innervation of the SNS. Results indicate that the region responsible for the growth promoting effects of GITR lies in its juxtamembrane intracellular region (here termed the growth promoting domain (GPD)) of GITR. The GPD of GITR activates ERK1/2 and inhibits nuclear factor kappa B (NF-κB) in an inverse fashion to provide an optimal cellular growth environment for P1 SCG neurons. While deleting the GPD of GITR had no effect on TrkA expression, constitutive phosphorylation of specific sites in the GPD reduced TrkA expression indicating a possible role for GITR in increasing the sensitivity of SCG neurons to NGF by the regulation of these sites, TrkA expression and subsequent NGF/TrkA binding. GITR appears to be heterogeneously required for NGF-promoted target innervation of SCG neurons in some organs, implying additional factors are involved in extensive NGF-target innervation of the SNS. In conclusion, this study answers basic biological questions regarding the molecular mechanism behind the role of GITR in the development of the SNS, and provides a basis for future research if GITR modulation is to be developed as a strategy for promoting axonal growth. Advisors/Committee Members: O'Keeffe, Gerard W., SFI.

Subjects/Keywords: GITR; Mouse; Sympathetic neurons; Growth; Neurons – Growth; Neurons – Physiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McKelvey, L. (2013). The role of glucocorticoid-induced tumour necrosis factor receptor in developing mouse sympathetic neurons. (Thesis). University College Cork. Retrieved from http://hdl.handle.net/10468/1291

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McKelvey, Laura. “The role of glucocorticoid-induced tumour necrosis factor receptor in developing mouse sympathetic neurons.” 2013. Thesis, University College Cork. Accessed February 18, 2020. http://hdl.handle.net/10468/1291.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McKelvey, Laura. “The role of glucocorticoid-induced tumour necrosis factor receptor in developing mouse sympathetic neurons.” 2013. Web. 18 Feb 2020.

Vancouver:

McKelvey L. The role of glucocorticoid-induced tumour necrosis factor receptor in developing mouse sympathetic neurons. [Internet] [Thesis]. University College Cork; 2013. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10468/1291.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McKelvey L. The role of glucocorticoid-induced tumour necrosis factor receptor in developing mouse sympathetic neurons. [Thesis]. University College Cork; 2013. Available from: http://hdl.handle.net/10468/1291

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Indian Institute of Science

16. Bhupatiraju, Sandeep. Some Aspects Of The First Passage Time Problem In Neuroscience.

Degree: 2010, Indian Institute of Science

URL: http://hdl.handle.net/2005/1343

► In the stochastic modeling of neurons, the first passage time problem arises as a natural object of study when considering the inter spike interval distribution.… (more)

Subjects/Keywords: Neurophysiology; Neurons - Time Passage; Voltage Impulses; Random Walks; Neurons - Modeling; Spike Trains (Neurons); Neuroscience

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bhupatiraju, S. (2010). Some Aspects Of The First Passage Time Problem In Neuroscience. (Thesis). Indian Institute of Science. Retrieved from http://hdl.handle.net/2005/1343

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bhupatiraju, Sandeep. “Some Aspects Of The First Passage Time Problem In Neuroscience.” 2010. Thesis, Indian Institute of Science. Accessed February 18, 2020. http://hdl.handle.net/2005/1343.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bhupatiraju, Sandeep. “Some Aspects Of The First Passage Time Problem In Neuroscience.” 2010. Web. 18 Feb 2020.

Vancouver:

Bhupatiraju S. Some Aspects Of The First Passage Time Problem In Neuroscience. [Internet] [Thesis]. Indian Institute of Science; 2010. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/2005/1343.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bhupatiraju S. Some Aspects Of The First Passage Time Problem In Neuroscience. [Thesis]. Indian Institute of Science; 2010. Available from: http://hdl.handle.net/2005/1343

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Indian Institute of Science

17. Bhupatiraju, Sandeep. Some Aspects Of The First Passage Time Problem In Neuroscience.

Degree: 2010, Indian Institute of Science

URL: http://etd.iisc.ernet.in/handle/2005/1343 ; http://etd.ncsi.iisc.ernet.in/abstracts/1737/G23707-Abs.pdf

► In the stochastic modeling of neurons, the first passage time problem arises as a natural object of study when considering the inter spike interval distribution.… (more)

Subjects/Keywords: Neurophysiology; Neurons - Time Passage; Voltage Impulses; Random Walks; Neurons - Modeling; Spike Trains (Neurons); Neuroscience

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bhupatiraju, S. (2010). Some Aspects Of The First Passage Time Problem In Neuroscience. (Thesis). Indian Institute of Science. Retrieved from http://etd.iisc.ernet.in/handle/2005/1343 ; http://etd.ncsi.iisc.ernet.in/abstracts/1737/G23707-Abs.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bhupatiraju, Sandeep. “Some Aspects Of The First Passage Time Problem In Neuroscience.” 2010. Thesis, Indian Institute of Science. Accessed February 18, 2020. http://etd.iisc.ernet.in/handle/2005/1343 ; http://etd.ncsi.iisc.ernet.in/abstracts/1737/G23707-Abs.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bhupatiraju, Sandeep. “Some Aspects Of The First Passage Time Problem In Neuroscience.” 2010. Web. 18 Feb 2020.

Vancouver:

Bhupatiraju S. Some Aspects Of The First Passage Time Problem In Neuroscience. [Internet] [Thesis]. Indian Institute of Science; 2010. [cited 2020 Feb 18]. Available from: http://etd.iisc.ernet.in/handle/2005/1343 ; http://etd.ncsi.iisc.ernet.in/abstracts/1737/G23707-Abs.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bhupatiraju S. Some Aspects Of The First Passage Time Problem In Neuroscience. [Thesis]. Indian Institute of Science; 2010. Available from: http://etd.iisc.ernet.in/handle/2005/1343 ; http://etd.ncsi.iisc.ernet.in/abstracts/1737/G23707-Abs.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Edinburgh

18. Caldwell, Lindsey Jane. Regeneration of dopaminergic neurons and other neuronal cell types in zebrafish.

Degree: PhD, 2019, University of Edinburgh

URL: http://hdl.handle.net/1842/35909

► Unlike mammals, zebrafish have a remarkable capacity to regenerate the central nervous system. Following neuronal loss by physical injury or chemical ablation zebrafish are capable… (more)

▼ Unlike mammals, zebrafish have a remarkable capacity to regenerate the central nervous system. Following neuronal loss by physical injury or chemical ablation zebrafish are capable of replacing neurons through increased neurogenesis, resulting in functional recovery. In the adult zebrafish brain, certain populations of dopaminergic and noradrenergic neurons, identified by immunohistochemistry for tyrosine hydroxylase (Th+), are regenerated after ablation with 6-hydroxydopamine (6OHDA), an analogue of dopamine commonly used to specifically ablate these neurons. Here I ask where these newly formed Th+ neurons originate and which signals are involved in their regeneration. In the adult zebrafish new neurons are derived from progenitor cells, the soma of which form part of the ependyma and which have radial processes extending to the pial surface, termed ependymo-radial glial cells (ERGs). In this thesis I show that ERGs lining the diencephalic ventricle are a heterogeneous population in terms of expression of her4, gfap, and olig2. Using genetic lineage tracing and proliferation analysis I demonstrate that regenerated Th+ neurons are derived from specific ERGs at the diencephalic ventricle. In contrast to mammals, Th+ neurons are constantly generated in the adult zebrafish brain. Here I show that injection of 6OHDA elicits an immune response, and that inhibiting this immune response with the artificial glucocorticoid dexamethasone attenuates proliferation of ERGs and neurogenesis of Th+ neurons to control levels. Although stimulating an immune response increases proliferation of ERGs, an immune response is not sufficient to increase Th+ neurogenesis. This demonstrates that an immune response is necessary but not sufficient for the regeneration of Th+ neurons in the adult zebrafish brain. Following a spinal cord lesion, both larvae and adult zebrafish are capable of functional regeneration. Spinal cord regeneration has been shown to involve increased neurogenesis of motor neurons; however, the extent to which other neuronal populations are regenerated has not been fully elucidated. Here I show that glutamatergic neurons are regenerated after a spinal cord lesion in larvae, and GABAergic neurons are regenerated in both larvae and adults. Taken together, these results provide new insights into the regeneration of the central nervous system in zebrafish. I identify populations of neurons which are regenerated, progenitor cells that give rise to regenerated neurons, and I demonstrate the pivotal role of the immune response in modulating regeneration. These results could ultimately inform future attempts to promote neuroregeneration in mammals.

Subjects/Keywords: zebrafish; neurogenesis; dopaminergic neurons; noradrenergic neurons; tyrosine hydroxylase; Th+ neurons; spinal cord regeneration

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Caldwell, L. J. (2019). Regeneration of dopaminergic neurons and other neuronal cell types in zebrafish. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/35909

Chicago Manual of Style (16^th Edition):

Caldwell, Lindsey Jane. “Regeneration of dopaminergic neurons and other neuronal cell types in zebrafish.” 2019. Doctoral Dissertation, University of Edinburgh. Accessed February 18, 2020. http://hdl.handle.net/1842/35909.

MLA Handbook (7^th Edition):

Caldwell, Lindsey Jane. “Regeneration of dopaminergic neurons and other neuronal cell types in zebrafish.” 2019. Web. 18 Feb 2020.

Vancouver:

Caldwell LJ. Regeneration of dopaminergic neurons and other neuronal cell types in zebrafish. [Internet] [Doctoral dissertation]. University of Edinburgh; 2019. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/1842/35909.

Council of Science Editors:

Caldwell LJ. Regeneration of dopaminergic neurons and other neuronal cell types in zebrafish. [Doctoral Dissertation]. University of Edinburgh; 2019. Available from: http://hdl.handle.net/1842/35909

University of Oxford

19. Mo, Mimi Shin Ning. Neural vulnerability in models of Parkinson's disease.

Degree: PhD, 2007, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:ac82e1c1-5d9f-473f-97ac-fcb70b2587ca ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595894

► Parkinson's disease (PD) is a neurodegenerative disorder with no known cure. This thesis explores the degenerative process in two neurotoxin-based models, the 6-hydroxydopamine and the… (more)

▼ Parkinson's disease (PD) is a neurodegenerative disorder with no known cure. This thesis explores the degenerative process in two neurotoxin-based models, the 6-hydroxydopamine and the chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)/probenecid mouse models, to yield important information about the pathogenesis of PD. Neuronal survival patterns in Parkinsonian patients and animals are heterogeneous. More dopaminergic neurons are lost from the ventral tier of the substantia nigra (SN) than from the dorsal tier or the adjacent ventral tegmental area, possibly due to differential expression of the calcium-binding protein, calbindin D28K. Brain sections were processed for tyrosine hydroxylase (TH) and calbindin (CB) immunocytochemistry to distinguish the dopaminergic subpopulations. I show that more TH+/CB- and TH-/CB+ than TH+/CB+ neurons are lost in both models, suggesting that CB confers some degree of protection for dopaminergic neurons. With respect to connectivity, I show that both TH+ and CB+ neurons receive striatal and dorsal raphe inputs. I investigated the possibility of a progressive loss in midbrain neurons by prolonging the post-lesion survival period. In both models, there is an irreversible neuronal cell loss of TH+, CB+ and TH+/CB+ neurons but the effects of survival time and lesion treatments differ for the three neuronal types. The lesions also appear to be toxic to GABAergic neurons. I explore whether, once neurodegeneration has started, neurons can be rescued by pharmacological intervention. Salicylic acid appears both to reduce microglial activation and significantly improve TH+, but not CB+ or TH+/CB+ neuronal survival. PD appears multifactorial in origin and may involve complex interactions between genetic and environmental influences. I show that a xenobiotic-metabolising enzyme, arylamine N-acetyltransferase may fulfil a neuroprotective role in the SN by limiting the environmental risks. Taken together, this study provides a body of information on two different mouse PD models and highlights possible genetic predispositions to PD neuropathology.

Subjects/Keywords: 616.8; Parkinson's disease; Pathogenesis; Neurons

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APA (6^th Edition):

Mo, M. S. N. (2007). Neural vulnerability in models of Parkinson's disease. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:ac82e1c1-5d9f-473f-97ac-fcb70b2587ca ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595894

Chicago Manual of Style (16^th Edition):

Mo, Mimi Shin Ning. “Neural vulnerability in models of Parkinson's disease.” 2007. Doctoral Dissertation, University of Oxford. Accessed February 18, 2020. http://ora.ox.ac.uk/objects/uuid:ac82e1c1-5d9f-473f-97ac-fcb70b2587ca ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595894.

MLA Handbook (7^th Edition):

Mo, Mimi Shin Ning. “Neural vulnerability in models of Parkinson's disease.” 2007. Web. 18 Feb 2020.

Vancouver:

Mo MSN. Neural vulnerability in models of Parkinson's disease. [Internet] [Doctoral dissertation]. University of Oxford; 2007. [cited 2020 Feb 18]. Available from: http://ora.ox.ac.uk/objects/uuid:ac82e1c1-5d9f-473f-97ac-fcb70b2587ca ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595894.

Council of Science Editors:

Mo MSN. Neural vulnerability in models of Parkinson's disease. [Doctoral Dissertation]. University of Oxford; 2007. Available from: http://ora.ox.ac.uk/objects/uuid:ac82e1c1-5d9f-473f-97ac-fcb70b2587ca ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595894

University of Edinburgh

20. Hughes, Mark Antony. Cell patterning and neuronal network engineering on parylene-C:SiO2 substrates.

Degree: PhD, 2014, University of Edinburgh

URL: http://hdl.handle.net/1842/10029

► Cell patterning platforms support diverse research goals including tissue engineering, the study of cell physiology, and the development of biosensors. Patterning and interfacing with neurons… (more)

▼ Cell patterning platforms support diverse research goals including tissue engineering, the study of cell physiology, and the development of biosensors. Patterning and interfacing with neurons is a particular challenge, being approached via various bioengineering approaches. Such constructs, when optimised, can inform our understanding of neuronal computation and learning, and ultimately aid the development of intelligent neuroprostheses. A fundamental pre-requisite is the ability to dictate the spatial organization and topography of patterned neuronal cells. This thesis details efforts to pattern neurons using photolithographically defined arrays of the polymer parylene-C, printed upon oxidised silicon wafers. Initial work focused on exploring the parylene-C:SiO2 construct as a wide-ranging cell-patterning platform, assessing cell adhesion from both substrate- and cell-centric perspectives. Next, the LUHMES (Lund Human Mesencephalic) cell line was used to explore the potential for construction of interrogatable, topographically-defined neuronal networks. In isolation, LUHMES neurons failed to pattern and did not show any morphological signs of cellular differentiation. However, in the context of a cellular template (the HEK 293 cell line which was found to pattern reliably), LUHMES were able to adhere secondarily on-chip. This co-culture environment promoted morphological differentiation of neurons. As such, HEK 293 cells fulfilled a role analogous to glia, dictating neuronal cell adhesion and generating an environment conducive to neuronal survival. Neurites extended between islands of adherent cell somata. The geometry and configuration of parylene-C influenced the organisation of neurites. With appropriate designs, orthogonal neuronal networks could be created. The dominant guidance cue for neurite growth direction appears to be a diffusible chemotactic agent. HEK 293 cells were later replaced with slower growing human glioma-derived precursors, extracted during tumour debulking surgery. These primary cells patterned accurately on parylene-C and provided a similarly effective, and longer lasting, scaffold for neuronal adhesion.

Subjects/Keywords: 617.4; neurons patterning; parylene; silicon

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hughes, M. A. (2014). Cell patterning and neuronal network engineering on parylene-C:SiO2 substrates. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/10029

Chicago Manual of Style (16^th Edition):

Hughes, Mark Antony. “Cell patterning and neuronal network engineering on parylene-C:SiO2 substrates.” 2014. Doctoral Dissertation, University of Edinburgh. Accessed February 18, 2020. http://hdl.handle.net/1842/10029.

MLA Handbook (7^th Edition):

Hughes, Mark Antony. “Cell patterning and neuronal network engineering on parylene-C:SiO2 substrates.” 2014. Web. 18 Feb 2020.

Vancouver:

Hughes MA. Cell patterning and neuronal network engineering on parylene-C:SiO2 substrates. [Internet] [Doctoral dissertation]. University of Edinburgh; 2014. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/1842/10029.

Council of Science Editors:

Hughes MA. Cell patterning and neuronal network engineering on parylene-C:SiO2 substrates. [Doctoral Dissertation]. University of Edinburgh; 2014. Available from: http://hdl.handle.net/1842/10029

University of Tasmania

21. Taylor, Bruce Vivian McArthur. The clinical & laboratory delineation of the syndrome of multifocal motor neuropathy with conduction block.

Degree: 2000, University of Tasmania

URL: https://eprints.utas.edu.au/22057/1/whole_TaylorBruceVivianMcArthur2000_thesis.pdf

Subjects/Keywords: Motor neurons

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APA (6^th Edition):

Taylor, B. V. M. (2000). The clinical & laboratory delineation of the syndrome of multifocal motor neuropathy with conduction block. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/22057/1/whole_TaylorBruceVivianMcArthur2000_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Taylor, Bruce Vivian McArthur. “The clinical & laboratory delineation of the syndrome of multifocal motor neuropathy with conduction block.” 2000. Thesis, University of Tasmania. Accessed February 18, 2020. https://eprints.utas.edu.au/22057/1/whole_TaylorBruceVivianMcArthur2000_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Taylor, Bruce Vivian McArthur. “The clinical & laboratory delineation of the syndrome of multifocal motor neuropathy with conduction block.” 2000. Web. 18 Feb 2020.

Vancouver:

Taylor BVM. The clinical & laboratory delineation of the syndrome of multifocal motor neuropathy with conduction block. [Internet] [Thesis]. University of Tasmania; 2000. [cited 2020 Feb 18]. Available from: https://eprints.utas.edu.au/22057/1/whole_TaylorBruceVivianMcArthur2000_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Taylor BVM. The clinical & laboratory delineation of the syndrome of multifocal motor neuropathy with conduction block. [Thesis]. University of Tasmania; 2000. Available from: https://eprints.utas.edu.au/22057/1/whole_TaylorBruceVivianMcArthur2000_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. Anita Rajah. The effect of a computer-aided cognitive enrichment programme on the scholastic performance of children: an exploratory study; -.

Degree: Clinical Psychology, 2012, Amrita Vishwa Vidyapeetham (University)

URL: http://shodhganga.inflibnet.ac.in/handle/10603/5704

►

Childhood is one of the most challenging stages of human life, characterized by constant growth and development- physically and psychologically. The normal growth and development… (more)

▼

Childhood is one of the most challenging stages of human life, characterized by constant growth and development- physically and psychologically. The normal growth and development of the brain occurs in parallel with the growth and development of cognitive functions. Atypical brain development may cause deficits in neuropsychological functions, resulting in academic difficulties. Attention, information processing and working memory are 3 functions that have been associated with scholastic problems in children. The lack of clarity in defining learning difficulty may lead to under-diagnosis of the problem in children and therefore, denial of possible help. Identifying children at risk and providing general intervention could be a model for prevention adopted in the Indian context. Average scholastic performance in lower classes can be a sign of risk for future difficulties in learning. Computer based interventions have scope for great use for children . Cogmed (for working memory) and FastForWord (for phonological processing) are 2 computer based programmes that have been repeatedly used with promising results. The Brain Functions Therapy(BFT), a computer-based programme developed in India, has been used in this study. This intervention targets core functions such as visuo-spatial processing, attention, working memory and response inhibition, which in turn contribute to intellectual and academic skills. The aim of the study was to assess the effectiveness of the BFT on the scholastic performance of children in classes 3, 4 and 5. The objectives of the study were to identify children with average scholastic performance in these classes, and assess their intellectual, academic and behavioural profile. The other objective was to find out the impact of the cognitive enrichment programme on the scholasticperformance, intellectual functioning and behaviour of these children. A before-after experimental design with controls was adopted for the present study.

References p.109-129, appendices include

Advisors/Committee Members: Anandkumar, A, Sundaram, K R.

Subjects/Keywords: Clinical Psychology; Brain; Neurons

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APA (6^th Edition):

Rajah, A. (2012). The effect of a computer-aided cognitive enrichment programme on the scholastic performance of children: an exploratory study; -. (Thesis). Amrita Vishwa Vidyapeetham (University). Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/5704

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rajah, Anita. “The effect of a computer-aided cognitive enrichment programme on the scholastic performance of children: an exploratory study; -.” 2012. Thesis, Amrita Vishwa Vidyapeetham (University). Accessed February 18, 2020. http://shodhganga.inflibnet.ac.in/handle/10603/5704.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rajah, Anita. “The effect of a computer-aided cognitive enrichment programme on the scholastic performance of children: an exploratory study; -.” 2012. Web. 18 Feb 2020.

Vancouver:

Rajah A. The effect of a computer-aided cognitive enrichment programme on the scholastic performance of children: an exploratory study; -. [Internet] [Thesis]. Amrita Vishwa Vidyapeetham (University); 2012. [cited 2020 Feb 18]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/5704.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rajah A. The effect of a computer-aided cognitive enrichment programme on the scholastic performance of children: an exploratory study; -. [Thesis]. Amrita Vishwa Vidyapeetham (University); 2012. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/5704

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Aberdeen

23. Stoney, Patrick Niall. The roles of Pax6 in neural precursor migration and axon guidance.

Degree: 2009, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=92509 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521239

► The ability of migrating neurons and growth cones to navigate through their environment is crucial for the correct development of the brain. Cells and growth… (more)

▼ The ability of migrating neurons and growth cones to navigate through their environment is crucial for the correct development of the brain. Cells and growth cones may be guided by electrical, chemical or topographical cues in their environment. Pax6 is a transcription factor vital for brain development. Pax6-/- mutant mice die perinatally with defects in neuronal proliferation and differentiation, cortical cell migration and axon guidance, yet it is not clear which guidance cues Pax6-/- mutant neurons fail to interpret. Dissociated cultured cells were used to study the cell-autonomous effects of Pax6 mutation on guidance of growth cones and migrating neural precursors by environmental cues. Neurites from mouse embryonic cortical neurons aligned perpendicular to 1 μm-wide, 130 nm-deep substratum grooves. Pax6-/- mutation abolished contact-mediated neurite guidance by these grooves. Laminin induced a switch from perpendicular to parallel alignment to grooves, via a β1 integrin-independent mechanism. Blocking cAMP signalling abolished perpendicular alignment to polylysine-coated grooves, but enhanced parallel alignment to laminin-coated grooves. Pax6 null mutation or overexpression also caused specific defects in contact-guided migration by cortical cells. An electric field applied to E16.5 cortical neurons increased the frequency of extension of neurites aligned perpendicular to the field axis. Pax6-/- mutant cells responded to an electric field with reduced anodal extension, but no significant increase in perpendicular neurite extension. Electrical cues were prioritised over topographical cues when presented in combination. Taken together, data suggest that Pax6 mutant cortical cells do not completely lack the ability to detect extracellular guidance cues, but they respond differently to wild-type cells. In combination with other defects identified in the cortex, this may contribute to the cell migration and axon guidance phenotypes in the brain of the Pax6-/- embryo. This study also identified novel Pax6 expression in the trigeminal ganglion, where it may regulate axon guidance and neurogenesis.

Subjects/Keywords: 573.8; Brain : Neurons : Hippocampus

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APA (6^th Edition):

Stoney, P. N. (2009). The roles of Pax6 in neural precursor migration and axon guidance. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=92509 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521239

Chicago Manual of Style (16^th Edition):

Stoney, Patrick Niall. “The roles of Pax6 in neural precursor migration and axon guidance.” 2009. Doctoral Dissertation, University of Aberdeen. Accessed February 18, 2020. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=92509 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521239.

MLA Handbook (7^th Edition):

Stoney, Patrick Niall. “The roles of Pax6 in neural precursor migration and axon guidance.” 2009. Web. 18 Feb 2020.

Vancouver:

Stoney PN. The roles of Pax6 in neural precursor migration and axon guidance. [Internet] [Doctoral dissertation]. University of Aberdeen; 2009. [cited 2020 Feb 18]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=92509 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521239.

Council of Science Editors:

Stoney PN. The roles of Pax6 in neural precursor migration and axon guidance. [Doctoral Dissertation]. University of Aberdeen; 2009. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=92509 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521239

University of Rochester

24. Yunes-Medina, Laura. The Role of Transglutaminase 2 in Neuronal Viability.

Degree: PhD, 2018, University of Rochester

URL: http://hdl.handle.net/1802/33408

► Neuronal viability is dependent on various pathways induced by the extracellular environment. If these pathways are disturbed neurons are more susceptible to injury. A protein… (more)

Subjects/Keywords: Transglutaminase 2; Hypoxia; Neurons

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APA (6^th Edition):

Yunes-Medina, L. (2018). The Role of Transglutaminase 2 in Neuronal Viability. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/33408

Chicago Manual of Style (16^th Edition):

Yunes-Medina, Laura. “The Role of Transglutaminase 2 in Neuronal Viability.” 2018. Doctoral Dissertation, University of Rochester. Accessed February 18, 2020. http://hdl.handle.net/1802/33408.

MLA Handbook (7^th Edition):

Yunes-Medina, Laura. “The Role of Transglutaminase 2 in Neuronal Viability.” 2018. Web. 18 Feb 2020.

Vancouver:

Yunes-Medina L. The Role of Transglutaminase 2 in Neuronal Viability. [Internet] [Doctoral dissertation]. University of Rochester; 2018. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/1802/33408.

Council of Science Editors:

Yunes-Medina L. The Role of Transglutaminase 2 in Neuronal Viability. [Doctoral Dissertation]. University of Rochester; 2018. Available from: http://hdl.handle.net/1802/33408

Louisiana State University

25. Paul, Latoya Telameca. Embyronic Nicotine Exposure and Its Impact on Spinal Neuron Development in Zebrafish.

Degree: PhD, 2010, Louisiana State University

URL: etd-04162010-182758 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3903

► Nicotine, a drug of abuse, has been shown to have deleterious outcomes on nervous system development in vertebrates. Using zebrafish behavior as a diagnostic tool,… (more)

▼ Nicotine, a drug of abuse, has been shown to have deleterious outcomes on nervous system development in vertebrates. Using zebrafish behavior as a diagnostic tool, we aimed to understand the effects of embryonic nicotine exposure on spinal neuron development. We initially quantified nicotine incorporation into zebrafish embryos. We found that only a fraction of the waterborne concentration of nicotine was incorporated into embryos. Also, when embryos were exposed to epibatidine and ABT 418, potent alpha 4/beta 2 nAChRs agonists, the embryos exhibited a robust swim-like behavioral response similar to that of nicotine. We then performed immunohistochemistry utilizing the mAB290 antibody and a zebrafish specific beta 2 antibody and found that Rohon-Beard (RB) neurons express the beta 2 subunit of nAChRs. Thus, we hypothesized that nicotine would have an effect on RB development. To test this, we first characterized RB neurons in embryonic zebrafish using known RB cellular markers. Early on, RB neurons form two rows in dorsal spinal cord then migrate medially towards the midline to form a linear row. We also examined the distribution of acetylated tubulin (aat), an indicator of programmed cell death (PCD) (Svoboda et al, 2001) in RB peripheral processes. We then evaluated the consequences of chronic nicotine exposure on RB neuron development. Altered distribution of aat in RB peripheral processes is a reliable marker for RB PCD. In nicotine exposed embryos, aat distribution appeared more continuous when compared to stage-matched controls. Also, RB migration to the midline was delayed. We conclude that chronic embryonic nicotine exposure can modulate RB PCD via nicotine binding to nAChRs expressed on RB neurons, thus play a neuroprotective role on RB development. Lastly, we discovered a novel zebrafish specific primary motoneuron marker. Upon using the beta 2 nAChR antibody, we noticed that not only RB neurons were labeled, but also primary motoneurons. To determine the stability and potential uses of this beta 2 nAChR antibody, we characterized beta 2 labeling in zebrafish ranging in age from 30 hpf to 12 dpf. We conclude that the beta 2 antibody specifically labels primary motoneurons consistently during development.

Subjects/Keywords: nicotine; Rohon-Beard neurons; zebrafish

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APA (6^th Edition):

Paul, L. T. (2010). Embyronic Nicotine Exposure and Its Impact on Spinal Neuron Development in Zebrafish. (Doctoral Dissertation). Louisiana State University. Retrieved from etd-04162010-182758 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3903

Chicago Manual of Style (16^th Edition):

Paul, Latoya Telameca. “Embyronic Nicotine Exposure and Its Impact on Spinal Neuron Development in Zebrafish.” 2010. Doctoral Dissertation, Louisiana State University. Accessed February 18, 2020. etd-04162010-182758 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3903.

MLA Handbook (7^th Edition):

Paul, Latoya Telameca. “Embyronic Nicotine Exposure and Its Impact on Spinal Neuron Development in Zebrafish.” 2010. Web. 18 Feb 2020.

Vancouver:

Paul LT. Embyronic Nicotine Exposure and Its Impact on Spinal Neuron Development in Zebrafish. [Internet] [Doctoral dissertation]. Louisiana State University; 2010. [cited 2020 Feb 18]. Available from: etd-04162010-182758 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3903.

Council of Science Editors:

Paul LT. Embyronic Nicotine Exposure and Its Impact on Spinal Neuron Development in Zebrafish. [Doctoral Dissertation]. Louisiana State University; 2010. Available from: etd-04162010-182758 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3903

Louisiana State University

26. Li, Jingyan. Surface-modified PLGA nanoparticles for targeted drug delivery to neurons.

Degree: MSBAE, Engineering, 2012, Louisiana State University

URL: etd-10242012-145420 ; https://digitalcommons.lsu.edu/gradschool_theses/4051

► The blood-brain barrier (BBB), which protects the central nervous system (CNS) from unnecessary substances, is a challenging obstacle in the treatment of CNS disease such… (more)

▼ The blood-brain barrier (BBB), which protects the central nervous system (CNS) from unnecessary substances, is a challenging obstacle in the treatment of CNS disease such as Parkinson’s Disease (PD). Many therapeutic agents such as hydrophilic and macromolecular drugs cannot overcome the BBB. One promising solution is the employment of polymeric nanoparticles (NPs) such as poly (lactic-co-glycolic acid) (PLGA) NPs as drug carrier. Over the past few years, significant breakthroughs have been made in developing suitable poly (lactic-co-glycolic acid) (PLGA) and poly (lactic acid) (PLA) nanoparticles for drug delivery across the BBB. Recent advances on PLGA/PLA NPs enhanced neural delivery of drugs were reviewed in the second chapter. Both in vitro and in vivo studies were included. In these papers, enhanced cellular uptake and therapeutic efficacy of drugs delivered with modified PLGA/PLA NPs compared to free drugs or drugs delivered by unmodified PLGA NPs was shown; no significant in vitro cytotoxicity was observed for PLGA NPs and PLA NPs. Surface modification of PLGA/PLA NPs by coating with surfactants/polymers or covalently conjugating with targeting ligands has been confirmed to enhance drug delivery across the BBB. Most unmodified PLGA NPs showed low brain uptake (<1%), which confirms the safety of PLGA/PLA NPs used for other purposes than treating CNS diseases. For the second part of the study, wheat germ agglutinin (WGA), a lectin was conjugated to PLGA nanoparticles (PLGA-tWGA NPs, 221 nm) to improve DAergic neuron delivery in C.elegans. PLGA-tWGA NPs did not show a significant effect on pumping rate and life span of C. elegans at low concentration (<3 mg/ml). Fluorescent studies of GFP-DAergic neurons revealed that area of GFP-DAergic neurons of worms treated with high concentrations PLGA-tWGA NPs (>3mg/ml) was significantly decreased. Number and mean intensity of GFP-DAergic neurons also decreased, but no significant difference was found compared with control group. Co-localization of the fluorescent particles with the GFP-DAergic neurons of treated worms proved targeting property of PLGA-tWGA nanoparticles to DAergic neurons. Enhanced targeted delivery of PLGA-tWGA NPs to neurons compared with tWGA and PLGA-t NPs made PLGA-tWGA NPs potential targeted neural delivery systems for the treatment of PD.

Subjects/Keywords: neurons; drug delivery; nanoparticles

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Li, J. (2012). Surface-modified PLGA nanoparticles for targeted drug delivery to neurons. (Masters Thesis). Louisiana State University. Retrieved from etd-10242012-145420 ; https://digitalcommons.lsu.edu/gradschool_theses/4051

Chicago Manual of Style (16^th Edition):

Li, Jingyan. “Surface-modified PLGA nanoparticles for targeted drug delivery to neurons.” 2012. Masters Thesis, Louisiana State University. Accessed February 18, 2020. etd-10242012-145420 ; https://digitalcommons.lsu.edu/gradschool_theses/4051.

MLA Handbook (7^th Edition):

Li, Jingyan. “Surface-modified PLGA nanoparticles for targeted drug delivery to neurons.” 2012. Web. 18 Feb 2020.

Vancouver:

Li J. Surface-modified PLGA nanoparticles for targeted drug delivery to neurons. [Internet] [Masters thesis]. Louisiana State University; 2012. [cited 2020 Feb 18]. Available from: etd-10242012-145420 ; https://digitalcommons.lsu.edu/gradschool_theses/4051.

Council of Science Editors:

Li J. Surface-modified PLGA nanoparticles for targeted drug delivery to neurons. [Masters Thesis]. Louisiana State University; 2012. Available from: etd-10242012-145420 ; https://digitalcommons.lsu.edu/gradschool_theses/4051

Ryerson University

27. McGarry, Lucy M. J. The role of the mirror neuron system in bottom-up and top-down perception of human action.

Degree: 2015, Ryerson University

URL: https://digital.library.ryerson.ca/islandora/object/RULA%3A3796

► When we see or hear another person execute an action, we tend to automatically simulate that action. Evidence for this has been found at the… (more)

Subjects/Keywords: Mirror neurons; Human behavior

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APA (6^th Edition):

McGarry, L. M. J. (2015). The role of the mirror neuron system in bottom-up and top-down perception of human action. (Thesis). Ryerson University. Retrieved from https://digital.library.ryerson.ca/islandora/object/RULA%3A3796

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McGarry, Lucy M J. “The role of the mirror neuron system in bottom-up and top-down perception of human action.” 2015. Thesis, Ryerson University. Accessed February 18, 2020. https://digital.library.ryerson.ca/islandora/object/RULA%3A3796.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McGarry, Lucy M J. “The role of the mirror neuron system in bottom-up and top-down perception of human action.” 2015. Web. 18 Feb 2020.

Vancouver:

McGarry LMJ. The role of the mirror neuron system in bottom-up and top-down perception of human action. [Internet] [Thesis]. Ryerson University; 2015. [cited 2020 Feb 18]. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A3796.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McGarry LMJ. The role of the mirror neuron system in bottom-up and top-down perception of human action. [Thesis]. Ryerson University; 2015. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A3796

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oregon

28. Clark, Matthew. Neural Basis of Locomotion in Drosophila Melanogaster Larvae.

Degree: 2018, University of Oregon

URL: http://hdl.handle.net/1794/23170

► Drosophila larval crawling is an attractive system to study patterned motor output at the level of animal behavior. Larval crawling consists of waves of muscle… (more)

▼ Drosophila larval crawling is an attractive system to study patterned motor output at the level of animal behavior. Larval crawling consists of waves of muscle contractions generating forward or reverse locomotion. In addition, larvae undergo additional behaviors including head casts, turning, and feeding. It is likely that some neurons are used in all these behaviors (e.g. motor neurons), but the identity (or even existence) of neurons dedicated to specific aspects of behavior is unclear. To identify neurons that regulate specific aspects of larval locomotion, we performed a genetic screen to identify neurons that, when activated, could elicit distinct motor programs. We defined 10 phenotypic categories that could uniquely be evoked upon stimulation, and provide further in depth analysis of two of these categories to understand the origins of the evoked behaviors. We first identified the evolutionarily conserved Even-skipped+ interneuron phenotype (Eve/Evx). Activation or ablation of Eve+ interneurons disrupted bilaterally symmetric muscle contraction amplitude, without affecting left-right synchronous timing. TEM reconstruction places the Eve+ interneurons at the heart of a sensorimotor circuit capable of detecting and modifying body wall muscle contraction We then went on to identify a unique pair of descending neurons dubbed the ‘Mooncrawler’ descending neurons (McDNs) to be sufficient to generate reverse locomotion. We show that the McDNs are present at larval hatching, function during larval life, and are remodeled during metamorphosis while maintaining basic morphological features and neural functions necessary to generate backwards locomotion. Finally, using serial section Transmission Electron Microscopy (ssTEM) to map neural connections to upstream and downstream elements provides a mechanistic view of how sensory information is received by the McDNs and transmitted to the VNC motor system to perform backwards locomotion. Finally, we show that these McDNs are the same as those identified in recent work in Drosophila adults (Bidaye et al. 2014) to be sufficient to generate reverse locomotion. This dissertation includes previously published, co-authored material. Advisors/Committee Members: doe, chris (advisor).

Subjects/Keywords: Command neurons; Drosophila; Neural circuits

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APA (6^th Edition):

Clark, M. (2018). Neural Basis of Locomotion in Drosophila Melanogaster Larvae. (Thesis). University of Oregon. Retrieved from http://hdl.handle.net/1794/23170

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Clark, Matthew. “Neural Basis of Locomotion in Drosophila Melanogaster Larvae.” 2018. Thesis, University of Oregon. Accessed February 18, 2020. http://hdl.handle.net/1794/23170.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Clark, Matthew. “Neural Basis of Locomotion in Drosophila Melanogaster Larvae.” 2018. Web. 18 Feb 2020.

Vancouver:

Clark M. Neural Basis of Locomotion in Drosophila Melanogaster Larvae. [Internet] [Thesis]. University of Oregon; 2018. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/1794/23170.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Clark M. Neural Basis of Locomotion in Drosophila Melanogaster Larvae. [Thesis]. University of Oregon; 2018. Available from: http://hdl.handle.net/1794/23170

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Montana State University

29. Herr, Alix Elise. The intercellular spread of alphaherpesviruses.

Degree: College of Letters & Science, 2018, Montana State University

URL: https://scholarworks.montana.edu/xmlui/handle/1/14184

► There are three prominent alphaherpesviruses that infect humans: Herpes Simplex virus-1, Herpes Simplex virus-2, and Varicella Zoster virus. Each virus is harbored within 15-98% of… (more)

▼ There are three prominent alphaherpesviruses that infect humans: Herpes Simplex virus-1, Herpes Simplex virus-2, and Varicella Zoster virus. Each virus is harbored within 15-98% of the population. Prototypical infections involve only a handful of intercellular spread events within a host. Most spread events involve neurons. Only one virion is thought to be successfully transmitted from a neuron to another cell – but this has yet to be verified during infectious spread within a host. In this dissertation, we used Pseudorabies virus to trace the number of virions spreading infection from infected neurons to uninfected cells. Pseudorabies virus is a prominent model alphaherpesvirus that infects mice. To quantify the number of virions transmitted between cells, we intravitreally injected different, genetically engineered Pseudorabies virus strains and quantified spread to the murine central nervous system. We calculated the average number of expressed viral genomes per infected neuron by utilizing the Poisson distributions of neurons expressing one, two, or three different viral strains. We found that when a neuronal axon transmitted infection to cells, a cell became infected with one virion on average. In contrast, when neuronal soma or dendrites transmitted the viral strains to surrounding cells, each cell expressed three viral genomes on average. Most importantly, we discovered that the absence of a specific alphaherpesviral protein, US9, diminished the capacity of the virus to infect a cell with a plurality of viral particles. This dissertation advanced the field of herpesviral research in two ways: by quantifying the number of alphaherpesviral particles transmitted between infected neurons in a host and identifying a viral protein instrumental in determining the number virions transmitted from neurons to other cells. The average number of viral particles infecting cells within a host determines the viral genetic dosage and impacts viral gene expression, viral replicative rates, and viral diversification. Advisors/Committee Members: Chairperson, Graduate Committee: Matt Taylor (advisor), Kyles S. Hain and Matthew P. Taylor were co-authors of the article, 'Limitations on the multiplicity of cellular infection during human alphaherpesviral disease' in the journal 'Current clinical microbiology reports' which is contained within this thesis. (other), Theresa Thornburg, Max DePartee, Ryan Waters and Matthew P. Taylor were co-authors of the article, 'The route of transmission from neurons impacts pseudorabies virus coinfection in vivo' submitted to the journal 'Journal of virology' which is contained within this thesis. (other).

Subjects/Keywords: Herpesvirus diseases.; Viruses.; Infection.; Neurons.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Herr, A. E. (2018). The intercellular spread of alphaherpesviruses. (Thesis). Montana State University. Retrieved from https://scholarworks.montana.edu/xmlui/handle/1/14184

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Herr, Alix Elise. “The intercellular spread of alphaherpesviruses.” 2018. Thesis, Montana State University. Accessed February 18, 2020. https://scholarworks.montana.edu/xmlui/handle/1/14184.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Herr, Alix Elise. “The intercellular spread of alphaherpesviruses.” 2018. Web. 18 Feb 2020.

Vancouver:

Herr AE. The intercellular spread of alphaherpesviruses. [Internet] [Thesis]. Montana State University; 2018. [cited 2020 Feb 18]. Available from: https://scholarworks.montana.edu/xmlui/handle/1/14184.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Herr AE. The intercellular spread of alphaherpesviruses. [Thesis]. Montana State University; 2018. Available from: https://scholarworks.montana.edu/xmlui/handle/1/14184

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Loughborough University

30. Pardo-Figuerez, Maria M. Designing neuronal networks with chemically modified substrates : an improved approach to conventional in vitro neural systems.

Degree: PhD, 2018, Loughborough University

URL: https://dspace.lboro.ac.uk/2134/27941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.740231

► Highly organised structures have been well-known to be part of the complex neuronal network presented in the nervous system, where thousands of neuronal connections are… (more)

▼ Highly organised structures have been well-known to be part of the complex neuronal network presented in the nervous system, where thousands of neuronal connections are arranged to give rise to critical physiological functions. Conventional in vitro culture methods are useful to represent simplistic neuronal behaviour, however, the lack of such organisation results in random and uncontrolled neurite spreading, leading to a lack of cell directionality and in turn, resulting in inaccurate neuronal in vitro models. Neurons are highly specialised cells, known to be greatly dependent on interactions with their surroundings. Therefore, when surface material is modified, drastic changes in neuronal behaviour can be achieved. The use of chemically modified surfaces in vitro has opened new avenues in cell culture, where the chaotic environment found in conventional culture methods can be controlled by the combination of surface modification methods with surface engineering techniques. Polymer brushes and self-assembled monolayers (SAMs) display a wide range of advantages as a surface modification tool for cell culture applications, since their properties can be finely tuned to promote or inhibit cellular adhesion, differentiation and proliferation. Therefore, when precisely combined with patterning techniques, a control over neuronal behaviour can be achieved. Neuronal patterning presents a system with instructive cues that can be used to study neuron-neuron communication by directing single neurites in specific locations to initiate synapses. Furthermore, although this area has not been much explored, the use of these patterned brushes could also be used in co-culture systems as a platform to closely monitor cell heterotypical communication. This research demonstrates the behaviour of SH-SY5Y neurons on a variety of SAMs and polymer brushes, both in isolation and combination to promote cellular spatial control. APTES and BIBB coatings promoted the highest cell viability, proliferation, metabolic activity and neuronal maturation, whilst low cell adhesion was seen on PKSPMA and PMETAC surfaces. Thereafter, PKSPMA brushes were used as a potential cell repulsive coating and its combination with micro- patterning techniques (photolithography and soft lithography) resulted in a system with instructive cues for neuronal guidance, where neuronal directionality was obtained. In the final chapter of this thesis, a chimeric co-culture system was developed where the patterned SH-SY5Y cells were co-cultured with C2C12 myoblasts in an attempt to obtain an organised neuronal-muscle co-culture system. Whilst preliminary observations showed first stages of a patterned neuronal-muscle co-culture, future work is necessary to refine and improve the patterned co-culture process.

Subjects/Keywords: Polymer brushes; SAMs; Neurons

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pardo-Figuerez, M. M. (2018). Designing neuronal networks with chemically modified substrates : an improved approach to conventional in vitro neural systems. (Doctoral Dissertation). Loughborough University. Retrieved from https://dspace.lboro.ac.uk/2134/27941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.740231

Chicago Manual of Style (16^th Edition):

Pardo-Figuerez, Maria M. “Designing neuronal networks with chemically modified substrates : an improved approach to conventional in vitro neural systems.” 2018. Doctoral Dissertation, Loughborough University. Accessed February 18, 2020. https://dspace.lboro.ac.uk/2134/27941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.740231.

MLA Handbook (7^th Edition):

Pardo-Figuerez, Maria M. “Designing neuronal networks with chemically modified substrates : an improved approach to conventional in vitro neural systems.” 2018. Web. 18 Feb 2020.

Vancouver:

Pardo-Figuerez MM. Designing neuronal networks with chemically modified substrates : an improved approach to conventional in vitro neural systems. [Internet] [Doctoral dissertation]. Loughborough University; 2018. [cited 2020 Feb 18]. Available from: https://dspace.lboro.ac.uk/2134/27941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.740231.

Council of Science Editors:

Pardo-Figuerez MM. Designing neuronal networks with chemically modified substrates : an improved approach to conventional in vitro neural systems. [Doctoral Dissertation]. Loughborough University; 2018. Available from: https://dspace.lboro.ac.uk/2134/27941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.740231

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Open Access Theses and Dissertations