subject:(Neurons)

Boston College

1. Pell, Diana. Return Map of a Periodically Driven Neuron.

Degree: MA, Mathematics, 2011, Boston College

URL: http://dlib.bc.edu/islandora/object/bc-ir:101218

► A typical neuron receives input from more than 10,000 other neurons. These inputs each get processed differently, depending on the neuron's morphology, chemistry, etc. The… (more)

Subjects/Keywords: Neurons

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APA (6^th Edition):

Pell, D. (2011). Return Map of a Periodically Driven Neuron. (Masters Thesis). Boston College. Retrieved from http://dlib.bc.edu/islandora/object/bc-ir:101218

Chicago Manual of Style (16^th Edition):

Pell, Diana. “Return Map of a Periodically Driven Neuron.” 2011. Masters Thesis, Boston College. Accessed April 10, 2021. http://dlib.bc.edu/islandora/object/bc-ir:101218.

MLA Handbook (7^th Edition):

Pell, Diana. “Return Map of a Periodically Driven Neuron.” 2011. Web. 10 Apr 2021.

Vancouver:

Pell D. Return Map of a Periodically Driven Neuron. [Internet] [Masters thesis]. Boston College; 2011. [cited 2021 Apr 10]. Available from: http://dlib.bc.edu/islandora/object/bc-ir:101218.

Council of Science Editors:

Pell D. Return Map of a Periodically Driven Neuron. [Masters Thesis]. Boston College; 2011. Available from: http://dlib.bc.edu/islandora/object/bc-ir:101218

Rutgers University

2. O'Neill, Kate M., 1989-. The role of brain-derived neurotrophic factor in the regulation of dendritic arbor morphology, neuronal network activity, and neuroprotection.

Degree: PhD, Biomedical Engineering, 2017, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/53958/

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The dendritic architecture of a neuron determines how it receives inputs, and thus, changes in dendrite morphology will affect connectivity among neurons. Aberrant changes in… (more)

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The dendritic architecture of a neuron determines how it receives inputs, and thus, changes in dendrite morphology will affect connectivity among neurons. Aberrant changes in the development of the arbor, or after the arbor has formed, can disrupt the functioning of neural circuits, causing severe brain dysfunction and leading to pathologies seen in cognitive disorders, neurological diseases, and trauma. Brain-derived neurotrophic factor (BDNF) is one of the most well-studied regulators of dendritic and synaptic plasticity. It is also known to be a pro-survival factor and is overexpressed in neurons that survive injuries, such as ischemia. This dissertation explores how BDNF shapes the dendritic arbor of single hippocampal neurons and the dynamics of in vitro hippocampal networks. Previous work in our laboratory has shown that BDNF significantly increases proximal dendrite branching in hippocampal neurons after 72 hours of bath application. Building on this work, we show that local application of BDNF via microbeads increases both proximal and distal dendrite branching in a shorter time than does bath application. We also show that overexpression of BDNF shapes the dendritic arbor differently depending on the intracellular targeting of BDNF transcripts. To understand how BDNF affects the development of hippocampal neuronal networks, we use microelectrode arrays (MEAs) to record the spontaneous activity of these networks before and after bath application of BDNF. Our results suggest a role for BDNF in the long-term development of neuronal network dynamics, as changes in network parameters were only observed at one week after treatment. Finally, we explore whether BDNF exerts neuroprotective effects following excitotoxic injury. Global activity parameters decrease following injury with excess glutamate with no benefit from BDNF treatment, but BDNF does protect connections with distinct baseline synchronizations from injury-induced decreases. Taken together, our results indicate that BDNF is involved in the development of the dendritic arbor, the maturation of neuronal networks, and the protection of distinct connections after excitotoxic injury.

Advisors/Committee Members: Firestein, Bonnie L (chair), Shinbrot, Troy (internal member), Paradiso, Ken (internal member), Thakker-Varia, Smita (internal member), Morrison, III, Barclay (outside member).

Subjects/Keywords: Neurons

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APA (6^th Edition):

O'Neill, Kate M., 1. (2017). The role of brain-derived neurotrophic factor in the regulation of dendritic arbor morphology, neuronal network activity, and neuroprotection. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/53958/

Chicago Manual of Style (16^th Edition):

O'Neill, Kate M., 1989-. “The role of brain-derived neurotrophic factor in the regulation of dendritic arbor morphology, neuronal network activity, and neuroprotection.” 2017. Doctoral Dissertation, Rutgers University. Accessed April 10, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/53958/.

MLA Handbook (7^th Edition):

O'Neill, Kate M., 1989-. “The role of brain-derived neurotrophic factor in the regulation of dendritic arbor morphology, neuronal network activity, and neuroprotection.” 2017. Web. 10 Apr 2021.

Vancouver:

O'Neill, Kate M. 1. The role of brain-derived neurotrophic factor in the regulation of dendritic arbor morphology, neuronal network activity, and neuroprotection. [Internet] [Doctoral dissertation]. Rutgers University; 2017. [cited 2021 Apr 10]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/53958/.

Council of Science Editors:

O'Neill, Kate M. 1. The role of brain-derived neurotrophic factor in the regulation of dendritic arbor morphology, neuronal network activity, and neuroprotection. [Doctoral Dissertation]. Rutgers University; 2017. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/53958/

University of Alberta

3. Vincent, Steven J. The costs and benefits of large neuronal ensembles and high firing rates for the transmission of information in neuronal systems.

Degree: MS, Department of Physiology, 1990, University of Alberta

URL: https://era.library.ualberta.ca/files/4m90dx58c

Subjects/Keywords: Neurons.

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APA (6^th Edition):

Vincent, S. J. (1990). The costs and benefits of large neuronal ensembles and high firing rates for the transmission of information in neuronal systems. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/4m90dx58c

Chicago Manual of Style (16^th Edition):

Vincent, Steven J. “The costs and benefits of large neuronal ensembles and high firing rates for the transmission of information in neuronal systems.” 1990. Masters Thesis, University of Alberta. Accessed April 10, 2021. https://era.library.ualberta.ca/files/4m90dx58c.

MLA Handbook (7^th Edition):

Vincent, Steven J. “The costs and benefits of large neuronal ensembles and high firing rates for the transmission of information in neuronal systems.” 1990. Web. 10 Apr 2021.

Vancouver:

Vincent SJ. The costs and benefits of large neuronal ensembles and high firing rates for the transmission of information in neuronal systems. [Internet] [Masters thesis]. University of Alberta; 1990. [cited 2021 Apr 10]. Available from: https://era.library.ualberta.ca/files/4m90dx58c.

Council of Science Editors:

Vincent SJ. The costs and benefits of large neuronal ensembles and high firing rates for the transmission of information in neuronal systems. [Masters Thesis]. University of Alberta; 1990. Available from: https://era.library.ualberta.ca/files/4m90dx58c

University of Aberdeen

4. Woolley, David. The actions of a soft coral derived natural product on neurones.

Degree: School of Medical Sciences, 2008, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=24801 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=24801&custom_att_2=simple_viewer

Subjects/Keywords: Neurons

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APA (6^th Edition):

Woolley, D. (2008). The actions of a soft coral derived natural product on neurones. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=24801 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=24801&custom_att_2=simple_viewer

Chicago Manual of Style (16^th Edition):

Woolley, David. “The actions of a soft coral derived natural product on neurones.” 2008. Doctoral Dissertation, University of Aberdeen. Accessed April 10, 2021. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=24801 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=24801&custom_att_2=simple_viewer.

MLA Handbook (7^th Edition):

Woolley, David. “The actions of a soft coral derived natural product on neurones.” 2008. Web. 10 Apr 2021.

Vancouver:

Woolley D. The actions of a soft coral derived natural product on neurones. [Internet] [Doctoral dissertation]. University of Aberdeen; 2008. [cited 2021 Apr 10]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=24801 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=24801&custom_att_2=simple_viewer.

Council of Science Editors:

Woolley D. The actions of a soft coral derived natural product on neurones. [Doctoral Dissertation]. University of Aberdeen; 2008. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=24801 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=24801&custom_att_2=simple_viewer

University of Texas – Austin

5. Gomez, Natalia. Studies on neuron responses to simultaneous and competing extracellular cues.

Degree: PhD, Chemical Engineering, 2006, University of Texas – Austin

URL: http://hdl.handle.net/2152/2694

► The understanding of cell responses to extracellular signals is a field of major importance. In particular, cell interactions with designed surfaces are fundamental for creating… (more)

▼ The understanding of cell responses to extracellular signals is a field of major importance. In particular, cell interactions with designed surfaces are fundamental for creating successful interfaces between biomaterials and biological entities. Bioactive materials that promote specific behaviors such as cell proliferation, migration or differentiation are highly relevant for tissue engineering strategies. In particular, neural engineering applications including nerve conduits for nerve regeneration, neural prosthetics and artificial neural networks, would be highly benefited from studies on artificial substrates that modulate neuronal behavior. Extracellular stimuli influence critical phases in neuronal development such as neuron polarization (i.e., axon formation) and axon growth. There are numerous stimuli that have been studied for influencing neuron responses. Some of these stimuli are substrate topography, growth factors, extracellular matrix components, electrical activity and the presence of support cells. Although all these stimuli induce responses in neurons independently, in this investigation we focused on cell behavior when simultaneous cues were presented to the cell. This included both combinatorial and competitive cues. We studied the novel combination of chemical and physical stimuli by immobilizing nerve growth factor (NGF) on topographical features. We found that topography (i.e., physical stimulus) highly influences axon formation, whereas axon extension is controlled by a synergy of immobilized NGF and topography. We also investigated the combination of electrical and chemical stimulation. In that case, NGF was immobilized on polypyrrole, an electrically- conducting polymer, finding an enhanced effect on neurite extension. Finally, simultaneous but spatially independent stimuli (i.e., competitive stimuli) were investigated for influencing direction of polarization. We found that physical cues were preferred over chemical cues for axon formation. Our results have contributed to further knowledge regarding the modification of artificial substrates that better control neuronal responses. This knowledge can be applied in the design of materials for nerve regeneration strategies, the modification of electrodes that stimulate neurons in prosthetic devices, and for the control of neuronal mapping and connectivity in neural nets. Advisors/Committee Members: Schmidt, Christine E. (advisor).

Subjects/Keywords: Neurons

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APA (6^th Edition):

Gomez, N. (2006). Studies on neuron responses to simultaneous and competing extracellular cues. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/2694

Chicago Manual of Style (16^th Edition):

Gomez, Natalia. “Studies on neuron responses to simultaneous and competing extracellular cues.” 2006. Doctoral Dissertation, University of Texas – Austin. Accessed April 10, 2021. http://hdl.handle.net/2152/2694.

MLA Handbook (7^th Edition):

Gomez, Natalia. “Studies on neuron responses to simultaneous and competing extracellular cues.” 2006. Web. 10 Apr 2021.

Vancouver:

Gomez N. Studies on neuron responses to simultaneous and competing extracellular cues. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2006. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/2152/2694.

Council of Science Editors:

Gomez N. Studies on neuron responses to simultaneous and competing extracellular cues. [Doctoral Dissertation]. University of Texas – Austin; 2006. Available from: http://hdl.handle.net/2152/2694

6. Moubarak, Estelle. Constraints imposed by morphological and biophysical properties of axon and dendrites on the electrical behaviour of rat substantia nigra pars compacta dopaminergic neurons : Contraintes imposées par les propriétés morphologiques et biophysiques de l'axone et des dendrites sur l'activité électrique des neurones dopaminergiques de la substance noire compacte de rat.

Degree: Docteur es, Neurosciences, 2018, Aix Marseille Université

URL: http://www.theses.fr/2018AIXM0746

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L’activité électrique des neurones est déterminée par des interactions complexes entre leurs propriétés morphologiques et biophysiques. Les neurones dopaminergiques (DA) de la substance noire compacte… (more)

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L’activité électrique des neurones est déterminée par des interactions complexes entre leurs propriétés morphologiques et biophysiques. Les neurones dopaminergiques (DA) de la substance noire compacte (SNc) présentent une caractéristique morphologique peu commune parmi les neurones de mammifères: leur axone émerge fréquemment d’une dendrite à une distance très variable du soma. Malgré cette importante variabilité dans la localisation de l’axone, peu d’articles ont étudié un lien potentiel entre morphologie neuronale et activité électrique dans ces cellules. Dans un premier article, nous avons exploré l’importante variabilité observée dans les neurones DA en caractérisant de nombreux paramètres morphologiques et biophysiques. Nos résultats suggèrent que la géométrie de l’AIS n’affecte pas significativement la forme du potentiel d’action ni l’activité pacemaker. En revanche, l’activité électrique est influencée par la morphologie et les conductances somatodendritiques. Dans une seconde étude, nous avons caractérisé le développement morphologique des neurones DA au cours des trois premières semaines post-natales. Nous avons observé une croissance asymétrique de l’arbre dendritique: la dendrite portant l’axone semble se complexifier plus que les autres dendrites. Cette asymétrie est associée à une contribution différente de la dendrite portant l’axone et des dendrites ne portant pas l’axone à la forme du potentiel d’action. Ces résultats suggèrent que les neurones DA de la SNc sont robustes aux variations morphologiques de l’axone et que les particularités morphologiques et biophysiques de leur arbre dendritique minimisent l’influence de l’AIS sur leur activité électrique.

Neuronal output is defined by the complex interplay between the biophysical and morphological properties of neurons. Dopaminergic (DA) neurons of the substantia nigra pars compacta (SNc) are spontaneously active and generate a regular pacemaking activity. While most mammalian neurons have an axon emerging from the soma, the axon of DA neurons often arises from a dendrite at highly variable distances from the soma. Despite this large cell-to-cell variation in axon location, few studies have tried to unravel the potential link between neuronal morphology and electrical behaviour in this cell type. In a first article, we explored the high degree of cell-to-cell variability found in DA neurons by characterising several morphological and biophysical parameters. While AIS geometry did not seem to significantly affect action potential shape or pacemaking activity, we found that the electrical behaviour of DA neurons was particularly sensitive to somatodendritic morphology and conductances. In a second study, we characterised the morphological development of DA neurons during the first three post-natal weeks. We observed an asymmetric development of the dendritic tree, favouring the elongation and complexity of the axon-bearing dendrite. This asymmetry is associated with different contributions of the axon-bearing and non-axon bearing dendrites to action…

Advisors/Committee Members: Goaillard, Jean-Marc (thesis director).

Subjects/Keywords: Neurones; Neurons

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APA (6^th Edition):

Moubarak, E. (2018). Constraints imposed by morphological and biophysical properties of axon and dendrites on the electrical behaviour of rat substantia nigra pars compacta dopaminergic neurons : Contraintes imposées par les propriétés morphologiques et biophysiques de l'axone et des dendrites sur l'activité électrique des neurones dopaminergiques de la substance noire compacte de rat. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2018AIXM0746

Chicago Manual of Style (16^th Edition):

Moubarak, Estelle. “Constraints imposed by morphological and biophysical properties of axon and dendrites on the electrical behaviour of rat substantia nigra pars compacta dopaminergic neurons : Contraintes imposées par les propriétés morphologiques et biophysiques de l'axone et des dendrites sur l'activité électrique des neurones dopaminergiques de la substance noire compacte de rat.” 2018. Doctoral Dissertation, Aix Marseille Université. Accessed April 10, 2021. http://www.theses.fr/2018AIXM0746.

MLA Handbook (7^th Edition):

Moubarak, Estelle. “Constraints imposed by morphological and biophysical properties of axon and dendrites on the electrical behaviour of rat substantia nigra pars compacta dopaminergic neurons : Contraintes imposées par les propriétés morphologiques et biophysiques de l'axone et des dendrites sur l'activité électrique des neurones dopaminergiques de la substance noire compacte de rat.” 2018. Web. 10 Apr 2021.

Vancouver:

Moubarak E. Constraints imposed by morphological and biophysical properties of axon and dendrites on the electrical behaviour of rat substantia nigra pars compacta dopaminergic neurons : Contraintes imposées par les propriétés morphologiques et biophysiques de l'axone et des dendrites sur l'activité électrique des neurones dopaminergiques de la substance noire compacte de rat. [Internet] [Doctoral dissertation]. Aix Marseille Université 2018. [cited 2021 Apr 10]. Available from: http://www.theses.fr/2018AIXM0746.

Council of Science Editors:

Moubarak E. Constraints imposed by morphological and biophysical properties of axon and dendrites on the electrical behaviour of rat substantia nigra pars compacta dopaminergic neurons : Contraintes imposées par les propriétés morphologiques et biophysiques de l'axone et des dendrites sur l'activité électrique des neurones dopaminergiques de la substance noire compacte de rat. [Doctoral Dissertation]. Aix Marseille Université 2018. Available from: http://www.theses.fr/2018AIXM0746

Rutgers University

7. Coffey, Kevin. Both the direct (Drd1) and indirect (Drd2) pathways contain type IIb neurons whose firing rates are related to stimulation of individual body parts.

Degree: PhD, Psychology, 2016, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/51252/

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The dorsolateral striatum (DLS) is a prominent target of research on control of voluntary movement and sensorimotor integration. The DLS is comprised mainly (95%) of… (more)

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The dorsolateral striatum (DLS) is a prominent target of research on control of voluntary movement and sensorimotor integration. The DLS is comprised mainly (95%) of medium spiny projection neurons that receive direct monosynaptic projections from primary somatosensory (S1) and motor (M1) cortices. Roughly 50% of these neurons are type IIb GABAergic, medium spiny projection neurons (MSNs) whose firing rates (FRs) are related to sensorimotor activity of individual body parts. There is also a hypothesized dual organization of DLS outputs known as the â€œdirect and indirect pathwaysâ€. According to this model, direct pathway MSNs project to the substantia nigra pars reticulata (SNr) and the internal segment of the globus pallidus (GPi), leading to disinhibition of the thalamus and facilitation of movement. Conversely the indirect pathway projects to the SNr via the globus pallidus external segment (GPe) and then the subthalamic nucleus (STN), inhibiting the thalamus and reducing movement. In addition to their distinct projections, MSNs of the direct and indirect pathway are characterized by differential expression of dopamine receptors. Dopamine Drd1 is expressed by direct pathway MSNs, whereas Drd2 is expressed by indirect pathway MSNs. While there has been a significant amount of research testing the functional hypotheses generated by iii the direct and indirect pathways framework, no study has attempted to reconcile the very well classified striatal type IIb neurons with the aforementioned functional tenet of the hypothesis. The present study utilized AAV-EF1a-FLEx-Chronos-GFP to visualize and optogenetically identify Drd1 and Drd2 MSNs in Cre-animals. We then performed somatosensory motor exams in order to identify type IIb MSNs and fill the gap in the literature. We found that in Drd1-Cre animals, Chronos-GFP expressing neurons projected to GPi, while in Drd2-Cre animals, Chronos-GFP expressing neurons projected to GPe, providing evidence that Drd1-Cre and Drd2-Cre animals are valid models of the direct and indirect pathways. Further, we were able to unambiguously identify Drd1 and Drd2 MSNs in the striatum of awake, behaving mice using light stimulation. We were subsequently able show that both the direct (Drd1) and indirect (Drd2) pathways contain type IIb neurons with firing related to stimulation of body parts. This evidence brings into question the notion that Drd1 neurons promote movement, while Drd2 neurons inhibit it. Rather, it seems that Drd1 and Drd2 neurons process sensorimotor information similarly, with both Drd1 and Drd2 neurons exhibiting increased phasic firing during body part stimulation and movement. While the anatomical aspects of the direct and indirect pathways hypothesis are strongly corroborated, the functional aspect appears to need a critical reevaluation.

Advisors/Committee Members: West, Mark O (chair), Kusnecov, Alex (internal member), Wagner, George (internal member), Margolis, David (outside member).

Subjects/Keywords: Optogenetics; Neurons

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APA (6^th Edition):

Coffey, K. (2016). Both the direct (Drd1) and indirect (Drd2) pathways contain type IIb neurons whose firing rates are related to stimulation of individual body parts. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/51252/

Chicago Manual of Style (16^th Edition):

Coffey, Kevin. “Both the direct (Drd1) and indirect (Drd2) pathways contain type IIb neurons whose firing rates are related to stimulation of individual body parts.” 2016. Doctoral Dissertation, Rutgers University. Accessed April 10, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/51252/.

MLA Handbook (7^th Edition):

Coffey, Kevin. “Both the direct (Drd1) and indirect (Drd2) pathways contain type IIb neurons whose firing rates are related to stimulation of individual body parts.” 2016. Web. 10 Apr 2021.

Vancouver:

Coffey K. Both the direct (Drd1) and indirect (Drd2) pathways contain type IIb neurons whose firing rates are related to stimulation of individual body parts. [Internet] [Doctoral dissertation]. Rutgers University; 2016. [cited 2021 Apr 10]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/51252/.

Council of Science Editors:

Coffey K. Both the direct (Drd1) and indirect (Drd2) pathways contain type IIb neurons whose firing rates are related to stimulation of individual body parts. [Doctoral Dissertation]. Rutgers University; 2016. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/51252/

Rutgers University

8. Liu, Wenke, 1986-. Intrinsic and synaptic membrane responses of murine spiral ganglion neurons.

Degree: PhD, Neuroscience, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/48601/

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As the first neuronal element in the auditory pathway, spiral ganglion neurons are responsible for the initial signal encoding of complex sound information. Experiments presented… (more)

Subjects/Keywords: Neurons; Synapses

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APA (6^th Edition):

Liu, Wenke, 1. (2015). Intrinsic and synaptic membrane responses of murine spiral ganglion neurons. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/48601/

Chicago Manual of Style (16^th Edition):

Liu, Wenke, 1986-. “Intrinsic and synaptic membrane responses of murine spiral ganglion neurons.” 2015. Doctoral Dissertation, Rutgers University. Accessed April 10, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/48601/.

MLA Handbook (7^th Edition):

Liu, Wenke, 1986-. “Intrinsic and synaptic membrane responses of murine spiral ganglion neurons.” 2015. Web. 10 Apr 2021.

Vancouver:

Liu, Wenke 1. Intrinsic and synaptic membrane responses of murine spiral ganglion neurons. [Internet] [Doctoral dissertation]. Rutgers University; 2015. [cited 2021 Apr 10]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48601/.

Council of Science Editors:

Liu, Wenke 1. Intrinsic and synaptic membrane responses of murine spiral ganglion neurons. [Doctoral Dissertation]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48601/

Oregon State University

9. Jacobs, Dakota. Effect of PFAS Exposure on Reproduction : a Comparative Investigation between Kisspeptin-secreting AVPV and Arcuate Nuclei.

Degree: MS, Toxicology, 2016, Oregon State University

URL: http://hdl.handle.net/1957/59888

► Ovulation requires preovulatory surges of gonadotropin-releasing hormone (GnRH) from preoptic hypothalamic neurons, initiated by elevated ovarian estradiol (E₂). Rising estradiol activates a subset of sexually… (more)

▼ Ovulation requires preovulatory surges of gonadotropin-releasing hormone (GnRH) from preoptic hypothalamic neurons, initiated by elevated ovarian estradiol (E₂). Rising estradiol activates a subset of sexually dimorphic kisspeptin (Kiss-1) neurons in the female, located in the anteroventral periventricular nuclei (AVPV). Conversely, estradiol negative feedback on GnRH secretion is mediated by a neuroanatomically separate population of Kiss-1 neurons in the arcuate nuclei. Kisspeptin stimulates GnRH expression and secretion in vivo, and the development of this system is critical for the initiation of puberty. To elucidate how phenotypically similar Kiss-1 neuronal populations react differentially to estradiol exposure, we have generated two immortalized Kiss-1 cell lines from kiss1-GFP post-pubertal female mice. These cell models recapitulate in vivo differential responsiveness to estradiol, with KTaV-3 (AVPV-derived) demonstrating ~6-fold increases in kiss1 expression under higher estradiol doses (5pM – 50pM E₂), while kiss1 expression in KTaR-1 cells is suppressed up to 80% under lower E2 concentrations (2pM – 10pM). We probed temporal patterns of kiss1 and core clock gene expression in these lines in response to estradiol, and found distinct antiphasic patterns of bmal1 and per2 in KTaV-3 cells irrespective of estradiol exposure. Treatment of KTaV-3 cells with 25pM E₂, however, elicited distinct patterns of kiss1 expression over time in contrast to vehicle, suggesting differential coupling of intracellular oscillators to kiss1 transcriptional activity in the presence of estradiol. Further, we have found that expression alterations between nuclear receptor ERα and ERβ genes, esr1 and esr2, respectively, fluctuate divergently between these lines. We have implicated that the peaks of kiss1 expression demonstrated by the KTaV-3 lines may be mediated by both classical and non-classical estrogen signaling. In addition, we provide evidence that the negative regulation of kiss1 expression in KTaR-1 cells may be a function of mutual antagonism due to overabundance of contemporaneously expressed esr1 and esr2 genes that is not observed in KTaV-3 lines. Lastly, we explored the impact of an endocrine disrupting class of perfluorinated alkyl substances (PFASs) on these neurons, with preliminary results illustrating kiss1, esr1, and esr2 transcriptional activation and/or repression at relevant doses of perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), and perfluorohexanoic acid (PFHxA) in the two lines. At extremely low doses of PFOA, typical estrogenic demonstrations of kiss1 expression are presented by KTaV-3 and KTaR-1 neurons. However at the same dose of PFOS the expression modulation of kiss1 gated by estrogen signaling in this hypothalamic populations is flipped. This implicates that a sufficient exposure to these ubiquitous chemicals can have a potent effect on neuronal expression profiles for estrogen sensitive genes that is a complex function of dose, particular PFAS, and tissue type. Ongoing… Advisors/Committee Members: Chappell, Patrick (advisor), Buermeyer, Andrew (committee member).

Subjects/Keywords: Kisspeptin; Kisspeptin neurons

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APA (6^th Edition):

Jacobs, D. (2016). Effect of PFAS Exposure on Reproduction : a Comparative Investigation between Kisspeptin-secreting AVPV and Arcuate Nuclei. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/59888

Chicago Manual of Style (16^th Edition):

Jacobs, Dakota. “Effect of PFAS Exposure on Reproduction : a Comparative Investigation between Kisspeptin-secreting AVPV and Arcuate Nuclei.” 2016. Masters Thesis, Oregon State University. Accessed April 10, 2021. http://hdl.handle.net/1957/59888.

MLA Handbook (7^th Edition):

Jacobs, Dakota. “Effect of PFAS Exposure on Reproduction : a Comparative Investigation between Kisspeptin-secreting AVPV and Arcuate Nuclei.” 2016. Web. 10 Apr 2021.

Vancouver:

Jacobs D. Effect of PFAS Exposure on Reproduction : a Comparative Investigation between Kisspeptin-secreting AVPV and Arcuate Nuclei. [Internet] [Masters thesis]. Oregon State University; 2016. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1957/59888.

Council of Science Editors:

Jacobs D. Effect of PFAS Exposure on Reproduction : a Comparative Investigation between Kisspeptin-secreting AVPV and Arcuate Nuclei. [Masters Thesis]. Oregon State University; 2016. Available from: http://hdl.handle.net/1957/59888

Columbia University

10. Glenwinkel, Lori Ann. In silico prediction of regulators of neuronal identity through phylogenetic footprinting.

Degree: 2018, Columbia University

URL: https://doi.org/10.7916/D8ZW33SC

► How individual neurons in a nervous system give rise to complex function, behavior and consciousness in higher animals has been studied for over a century,… (more)

Subjects/Keywords: Biometry; Phylogeny; Neurons

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APA (6^th Edition):

Glenwinkel, L. A. (2018). In silico prediction of regulators of neuronal identity through phylogenetic footprinting. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8ZW33SC

Chicago Manual of Style (16^th Edition):

Glenwinkel, Lori Ann. “In silico prediction of regulators of neuronal identity through phylogenetic footprinting.” 2018. Doctoral Dissertation, Columbia University. Accessed April 10, 2021. https://doi.org/10.7916/D8ZW33SC.

MLA Handbook (7^th Edition):

Glenwinkel, Lori Ann. “In silico prediction of regulators of neuronal identity through phylogenetic footprinting.” 2018. Web. 10 Apr 2021.

Vancouver:

Glenwinkel LA. In silico prediction of regulators of neuronal identity through phylogenetic footprinting. [Internet] [Doctoral dissertation]. Columbia University; 2018. [cited 2021 Apr 10]. Available from: https://doi.org/10.7916/D8ZW33SC.

Council of Science Editors:

Glenwinkel LA. In silico prediction of regulators of neuronal identity through phylogenetic footprinting. [Doctoral Dissertation]. Columbia University; 2018. Available from: https://doi.org/10.7916/D8ZW33SC

Drexel University

11. Henderson, Max. The Effects of Aging on Neural Processes and Microcolumnar Networks.

Degree: 2015, Drexel University

URL: http://hdl.handle.net/1860/idea:7240

►

Many areas of the human brain show intrinsic geometric order. This research focuses on particular substructures called microcolumns, which are vertically oriented clusters of neurons… (more)

Subjects/Keywords: Aging; Neurons; Physics

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APA (6^th Edition):

Henderson, M. (2015). The Effects of Aging on Neural Processes and Microcolumnar Networks. (Thesis). Drexel University. Retrieved from http://hdl.handle.net/1860/idea:7240

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Henderson, Max. “The Effects of Aging on Neural Processes and Microcolumnar Networks.” 2015. Thesis, Drexel University. Accessed April 10, 2021. http://hdl.handle.net/1860/idea:7240.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Henderson, Max. “The Effects of Aging on Neural Processes and Microcolumnar Networks.” 2015. Web. 10 Apr 2021.

Vancouver:

Henderson M. The Effects of Aging on Neural Processes and Microcolumnar Networks. [Internet] [Thesis]. Drexel University; 2015. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1860/idea:7240.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Henderson M. The Effects of Aging on Neural Processes and Microcolumnar Networks. [Thesis]. Drexel University; 2015. Available from: http://hdl.handle.net/1860/idea:7240

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. Gilmore, Ian Richard. Quantitative proteomic analysis of the effect of 24(S),25-epoxycholesterol on SN4741 neuron cells.

Degree: PhD, 2013, Swansea University

URL: https://cronfa.swan.ac.uk/Record/cronfa42712 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678489

► Oxysterols are oxygenated derivatives of cholesterol or its precursors. One oxysterol, 24(S),25-epoxycholesterol (24(S),25-EC), which results from a shunt in the cholesterol synthesis pathway has been… (more)

▼ Oxysterols are oxygenated derivatives of cholesterol or its precursors. One oxysterol, 24(S),25-epoxycholesterol (24(S),25-EC), which results from a shunt in the cholesterol synthesis pathway has been found at higher than expected levels in embryonic murine brain. Interestingly, the receptor that 24(5),25-EC is a ligand for, Liver X Receptor (LXR), has been implicated in neurogenesis in the ventral mid brain region of embryonic brain; an area with a high density of dopaminergic neurons. The mechanism by which LXR induces this effect is unclear. Therefore, proteomic and phosphoproteomic studies were performed using a stable isotope labelled in amino acid in cell culture (SILAC) approach in order to quantify changes in the proteome between different treatment groups in a mouse substantia nigra dopaminergic cell line (SN4741) SN4741 cells were cultured in SILAC media containing differentially isotope labelled arginine and lysine. For protein expression studies SN4741 cells were treated in serum free media with vehicle, 10muM 24(S),25-EC, or 1muM GW3965, a synthetic ligand of LXR, for 24 hours. For analysis of changes in the phosphoproteome SN4741 cells were treated in serum free media with vehicle, 10muM 24(5),25-EC, or 30muM 25- hydroxycholesterol for 6 hours. Cells were lysed and protein combined in a 1:1 ratio before trypsin digestion and peptide separation via strong cation exchange chromatography. Phosphopeptides were enriched using immobilised metal affinity chromatography (IMAC). Resulting fractions were analysed, using a data dependent LC-MS/MS method. Data was quantified using MaxQuant software in conjunction with Mascot using an IPl mouse database. In protein expression analysis known oxysterol regulated genes, via SREBP or LXR, were differentially expressed. Oxysterol treatment induced global changes in proteins involved in lipid (cholesterol, fatty acid, phospholipid, triglyceride) synthesis. LXR? protein expression increased after GW3965 and 24(5),25-EC treatment, though no change was seen on LXRp mRNA, implying that ligand binding protects LXR? from degradation. 24(S),25-EC induced changes in expression and localisation of the membrane protein caveolin-1. Also, phosphoethanolamine cytidylyltransferase and collagen type IV alpha-3-binding protein, 2 proteins involved in phospholipid synthesis, had an altered expression after 24(S),25-EC treatment suggesting a role for oxysterols in membrane homeostasis. A cytokine, macrophage colony stimulating factor, which is required for normal neuronal development and macrophage differentiation had an LXR independent increased expression after 24(S),25-EC treatment. Quantitative RT-PCR data demonstrated that proteomic changes were due to both transcriptional and post-transcriptional effects of oxysterol. In addition, studies examining changes in the mouse phosphoproteome identified a number of novel phosphorylation sites.

Subjects/Keywords: 573.8; Proteomics; Neurons

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APA (6^th Edition):

Gilmore, I. R. (2013). Quantitative proteomic analysis of the effect of 24(S),25-epoxycholesterol on SN4741 neuron cells. (Doctoral Dissertation). Swansea University. Retrieved from https://cronfa.swan.ac.uk/Record/cronfa42712 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678489

Chicago Manual of Style (16^th Edition):

Gilmore, Ian Richard. “Quantitative proteomic analysis of the effect of 24(S),25-epoxycholesterol on SN4741 neuron cells.” 2013. Doctoral Dissertation, Swansea University. Accessed April 10, 2021. https://cronfa.swan.ac.uk/Record/cronfa42712 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678489.

MLA Handbook (7^th Edition):

Gilmore, Ian Richard. “Quantitative proteomic analysis of the effect of 24(S),25-epoxycholesterol on SN4741 neuron cells.” 2013. Web. 10 Apr 2021.

Vancouver:

Gilmore IR. Quantitative proteomic analysis of the effect of 24(S),25-epoxycholesterol on SN4741 neuron cells. [Internet] [Doctoral dissertation]. Swansea University; 2013. [cited 2021 Apr 10]. Available from: https://cronfa.swan.ac.uk/Record/cronfa42712 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678489.

Council of Science Editors:

Gilmore IR. Quantitative proteomic analysis of the effect of 24(S),25-epoxycholesterol on SN4741 neuron cells. [Doctoral Dissertation]. Swansea University; 2013. Available from: https://cronfa.swan.ac.uk/Record/cronfa42712 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678489

Rutgers University

13. Hamod, Aula, 1982-. Purifications of small molecules that regulate neuronal cell-lineage specification.

Degree: MS, Physiology and Integrative Biology, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/48504/

► There are certain important factors that are essential for specification, development and maintenance vertebrate nervous system. During development these factors regulate axonal growth, dendrite pruning,… (more)

Subjects/Keywords: Nervous system; Neurons

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APA (6^th Edition):

Hamod, Aula, 1. (2015). Purifications of small molecules that regulate neuronal cell-lineage specification. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/48504/

Chicago Manual of Style (16^th Edition):

Hamod, Aula, 1982-. “Purifications of small molecules that regulate neuronal cell-lineage specification.” 2015. Masters Thesis, Rutgers University. Accessed April 10, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/48504/.

MLA Handbook (7^th Edition):

Hamod, Aula, 1982-. “Purifications of small molecules that regulate neuronal cell-lineage specification.” 2015. Web. 10 Apr 2021.

Vancouver:

Hamod, Aula 1. Purifications of small molecules that regulate neuronal cell-lineage specification. [Internet] [Masters thesis]. Rutgers University; 2015. [cited 2021 Apr 10]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48504/.

Council of Science Editors:

Hamod, Aula 1. Purifications of small molecules that regulate neuronal cell-lineage specification. [Masters Thesis]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48504/

Rutgers University

14. Ünal, Bengi, 1982-. Tyrosine hydroxylase-expressing interneurons in intact and dopamine-depleted striatum.

Degree: PhD, Behavioral and Neural Sciences, 2012, Rutgers University

URL: http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000066590

►

Tyrosine hydroxylase-expressing (TH+) interneurons of the striatum stand in a critical point for our understanding of the interaction between striatal dopamine and striatal interneurons. Recent… (more)

▼

Tyrosine hydroxylase-expressing (TH+) interneurons of the striatum stand in a critical point for our understanding of the interaction between striatal dopamine and striatal interneurons. Recent investigations from our laboratory have established that TH+ neurons comprise an electrophysiologically distinct group striatal GABAergic interneurons by using transgenic mice expressing enhanced green fluorescent protein under the control TH promoter (TH-eGFP). In order to understand the significance of striatal TH+ neurons in the normal and dopamine-depleted striatum, determining anatomical distribution of TH+ neurons with regard to their electrophysiological diversity and striatal anatomical heterogeneity was imperative. In the first part of my thesis, I investigated striatal localization of TH-eGFP neurons with respect to anatomical organization of the striatum. In the second set of experiments, I investigated the changes in anatomical distribution, morphology, and electrophysiology of TH-eGFP neurons following striatal dopamine-depletion. Data presented here indicates that the electrophysiological subtypes of TH-eGFP interneurons are equally prevalent throughout striatum. However, when patch/striosome-matrix organization is taken into account, a different pattern emerges in the dorso-ventral axis of the striatum: a significantly higher proportion of striatal TH-eGFP interneurons were located in MOR-enriched domains of the ventral striatum. Finally, TH-eGFP interneurons in both compartments extended their neurites into the neighboring compartment. In the second set of experiments, I investigated the effect of striatal dopamine loss achieved by unilateral intranigral 6-OHDA infusion on TH-eGFP interneuron anatomy and physiology. The data presented here show that dopamine loss has a temporally and regionally different effect on the number of striatal TH-eGFP interneurons. Several electrophysiological parameters of TH-eGFP interneurons show profound changes in dopamine-depleted striatum, such as reduction in plateau potentials and increase in spontaneous synaptic inputs, which were accompanied by a significant increase in spine density on these neurons. Taken together, the findings in this thesis establish that TH-eGFP neurons are a distinct group of striatal interneurons that show differential anatomical patterning throughout the dorsal-ventral axis of the striatum and respond to striatal dopamine-loss in a qualitatively and quantitatively different manner than striatal projection neurons.

Advisors/Committee Members: Ünal, Bengi, 1982- (author), Abercrombie, Elizabeth D (chair), Tepper, James M (internal member), Jonakait, G Miller (internal member), Zaborszky, Laszlo (internal member), Smith, Yoland (outside member).

Subjects/Keywords: Interneurons; Dopaminergic neurons

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ünal, Bengi, 1. (2012). Tyrosine hydroxylase-expressing interneurons in intact and dopamine-depleted striatum. (Doctoral Dissertation). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000066590

Chicago Manual of Style (16^th Edition):

Ünal, Bengi, 1982-. “Tyrosine hydroxylase-expressing interneurons in intact and dopamine-depleted striatum.” 2012. Doctoral Dissertation, Rutgers University. Accessed April 10, 2021. http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000066590.

MLA Handbook (7^th Edition):

Ünal, Bengi, 1982-. “Tyrosine hydroxylase-expressing interneurons in intact and dopamine-depleted striatum.” 2012. Web. 10 Apr 2021.

Vancouver:

Ünal, Bengi 1. Tyrosine hydroxylase-expressing interneurons in intact and dopamine-depleted striatum. [Internet] [Doctoral dissertation]. Rutgers University; 2012. [cited 2021 Apr 10]. Available from: http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000066590.

Council of Science Editors:

Ünal, Bengi 1. Tyrosine hydroxylase-expressing interneurons in intact and dopamine-depleted striatum. [Doctoral Dissertation]. Rutgers University; 2012. Available from: http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000066590

University College Cork

15. McKelvey, Laura. The role of glucocorticoid-induced tumour necrosis factor receptor in developing mouse sympathetic neurons.

Degree: 2013, University College Cork

URL: http://hdl.handle.net/10468/1291

► Hereditary sensory autonomic neuropathy IV (HSAN IV) is an autosomal recessive disorder characterised by inability to feel pain and anhidrosis and is a consequence of… (more)

▼ Hereditary sensory autonomic neuropathy IV (HSAN IV) is an autosomal recessive disorder characterised by inability to feel pain and anhidrosis and is a consequence of defective NGF/TrkA signalling and growth of sensory and sympathetic neurons. Glucocortiocoid-induced tumour necrosis factors receptor (GITR), a transmembrane protein, activated by its specific ligand, GITRL, is well known for its role in the regulation of innate and acquired immune system responses. Recently, GITR was found to be required for NGF-dependant and extracellular signal-related kinase 1/2 (ERK1/2)-induced neurite growth and target innervation in the developing sympathetic nervous system (SNS). Given this novel role of GITR, it is possible that strategies targeting GITR have potential therapeutic benefit in promoting neurite growth in autonomic neuropathies such as HSAN IV. Using P1 mouse SCG neurons as a model, in addition to various SCG cell treatments, knock down models and transfection methods, we investigated whether GITR increases the sensitivity of sympathetic neurons to NGF; the region of GITR required for the enhancement of NGF-promoted growth, the signalling pathways downstream of GITR and how extensively GITR is involved in regulating peripheral innervation of the SNS. Results indicate that the region responsible for the growth promoting effects of GITR lies in its juxtamembrane intracellular region (here termed the growth promoting domain (GPD)) of GITR. The GPD of GITR activates ERK1/2 and inhibits nuclear factor kappa B (NF-κB) in an inverse fashion to provide an optimal cellular growth environment for P1 SCG neurons. While deleting the GPD of GITR had no effect on TrkA expression, constitutive phosphorylation of specific sites in the GPD reduced TrkA expression indicating a possible role for GITR in increasing the sensitivity of SCG neurons to NGF by the regulation of these sites, TrkA expression and subsequent NGF/TrkA binding. GITR appears to be heterogeneously required for NGF-promoted target innervation of SCG neurons in some organs, implying additional factors are involved in extensive NGF-target innervation of the SNS. In conclusion, this study answers basic biological questions regarding the molecular mechanism behind the role of GITR in the development of the SNS, and provides a basis for future research if GITR modulation is to be developed as a strategy for promoting axonal growth. Advisors/Committee Members: O'Keeffe, Gerard W., SFI.

Subjects/Keywords: GITR; Mouse; Sympathetic neurons; Growth; Neurons – Growth; Neurons – Physiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McKelvey, L. (2013). The role of glucocorticoid-induced tumour necrosis factor receptor in developing mouse sympathetic neurons. (Thesis). University College Cork. Retrieved from http://hdl.handle.net/10468/1291

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McKelvey, Laura. “The role of glucocorticoid-induced tumour necrosis factor receptor in developing mouse sympathetic neurons.” 2013. Thesis, University College Cork. Accessed April 10, 2021. http://hdl.handle.net/10468/1291.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McKelvey, Laura. “The role of glucocorticoid-induced tumour necrosis factor receptor in developing mouse sympathetic neurons.” 2013. Web. 10 Apr 2021.

Vancouver:

McKelvey L. The role of glucocorticoid-induced tumour necrosis factor receptor in developing mouse sympathetic neurons. [Internet] [Thesis]. University College Cork; 2013. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10468/1291.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McKelvey L. The role of glucocorticoid-induced tumour necrosis factor receptor in developing mouse sympathetic neurons. [Thesis]. University College Cork; 2013. Available from: http://hdl.handle.net/10468/1291

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Indian Institute of Science

16. Bhupatiraju, Sandeep. Some Aspects Of The First Passage Time Problem In Neuroscience.

Degree: MS, Faculty of Science, 2011, Indian Institute of Science

URL: http://etd.iisc.ac.in/handle/2005/1343

► In the stochastic modeling of neurons, the first passage time problem arises as a natural object of study when considering the inter spike interval distribution.… (more)

Subjects/Keywords: Neurophysiology; Neurons - Time Passage; Voltage Impulses; Random Walks; Neurons - Modeling; Spike Trains (Neurons); Neuroscience

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APA (6^th Edition):

Bhupatiraju, S. (2011). Some Aspects Of The First Passage Time Problem In Neuroscience. (Masters Thesis). Indian Institute of Science. Retrieved from http://etd.iisc.ac.in/handle/2005/1343

Chicago Manual of Style (16^th Edition):

Bhupatiraju, Sandeep. “Some Aspects Of The First Passage Time Problem In Neuroscience.” 2011. Masters Thesis, Indian Institute of Science. Accessed April 10, 2021. http://etd.iisc.ac.in/handle/2005/1343.

MLA Handbook (7^th Edition):

Bhupatiraju, Sandeep. “Some Aspects Of The First Passage Time Problem In Neuroscience.” 2011. Web. 10 Apr 2021.

Vancouver:

Bhupatiraju S. Some Aspects Of The First Passage Time Problem In Neuroscience. [Internet] [Masters thesis]. Indian Institute of Science; 2011. [cited 2021 Apr 10]. Available from: http://etd.iisc.ac.in/handle/2005/1343.

Council of Science Editors:

Bhupatiraju S. Some Aspects Of The First Passage Time Problem In Neuroscience. [Masters Thesis]. Indian Institute of Science; 2011. Available from: http://etd.iisc.ac.in/handle/2005/1343

University of Edinburgh

17. Caldwell, Lindsey Jane. Regeneration of dopaminergic neurons and other neuronal cell types in zebrafish.

Degree: PhD, 2019, University of Edinburgh

URL: http://hdl.handle.net/1842/35909

► Unlike mammals, zebrafish have a remarkable capacity to regenerate the central nervous system. Following neuronal loss by physical injury or chemical ablation zebrafish are capable… (more)

▼ Unlike mammals, zebrafish have a remarkable capacity to regenerate the central nervous system. Following neuronal loss by physical injury or chemical ablation zebrafish are capable of replacing neurons through increased neurogenesis, resulting in functional recovery. In the adult zebrafish brain, certain populations of dopaminergic and noradrenergic neurons, identified by immunohistochemistry for tyrosine hydroxylase (Th+), are regenerated after ablation with 6-hydroxydopamine (6OHDA), an analogue of dopamine commonly used to specifically ablate these neurons. Here I ask where these newly formed Th+ neurons originate and which signals are involved in their regeneration. In the adult zebrafish new neurons are derived from progenitor cells, the soma of which form part of the ependyma and which have radial processes extending to the pial surface, termed ependymo-radial glial cells (ERGs). In this thesis I show that ERGs lining the diencephalic ventricle are a heterogeneous population in terms of expression of her4, gfap, and olig2. Using genetic lineage tracing and proliferation analysis I demonstrate that regenerated Th+ neurons are derived from specific ERGs at the diencephalic ventricle. In contrast to mammals, Th+ neurons are constantly generated in the adult zebrafish brain. Here I show that injection of 6OHDA elicits an immune response, and that inhibiting this immune response with the artificial glucocorticoid dexamethasone attenuates proliferation of ERGs and neurogenesis of Th+ neurons to control levels. Although stimulating an immune response increases proliferation of ERGs, an immune response is not sufficient to increase Th+ neurogenesis. This demonstrates that an immune response is necessary but not sufficient for the regeneration of Th+ neurons in the adult zebrafish brain. Following a spinal cord lesion, both larvae and adult zebrafish are capable of functional regeneration. Spinal cord regeneration has been shown to involve increased neurogenesis of motor neurons; however, the extent to which other neuronal populations are regenerated has not been fully elucidated. Here I show that glutamatergic neurons are regenerated after a spinal cord lesion in larvae, and GABAergic neurons are regenerated in both larvae and adults. Taken together, these results provide new insights into the regeneration of the central nervous system in zebrafish. I identify populations of neurons which are regenerated, progenitor cells that give rise to regenerated neurons, and I demonstrate the pivotal role of the immune response in modulating regeneration. These results could ultimately inform future attempts to promote neuroregeneration in mammals.

Subjects/Keywords: zebrafish; neurogenesis; dopaminergic neurons; noradrenergic neurons; tyrosine hydroxylase; Th+ neurons; spinal cord regeneration

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Caldwell, L. J. (2019). Regeneration of dopaminergic neurons and other neuronal cell types in zebrafish. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/35909

Chicago Manual of Style (16^th Edition):

Caldwell, Lindsey Jane. “Regeneration of dopaminergic neurons and other neuronal cell types in zebrafish.” 2019. Doctoral Dissertation, University of Edinburgh. Accessed April 10, 2021. http://hdl.handle.net/1842/35909.

MLA Handbook (7^th Edition):

Caldwell, Lindsey Jane. “Regeneration of dopaminergic neurons and other neuronal cell types in zebrafish.” 2019. Web. 10 Apr 2021.

Vancouver:

Caldwell LJ. Regeneration of dopaminergic neurons and other neuronal cell types in zebrafish. [Internet] [Doctoral dissertation]. University of Edinburgh; 2019. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1842/35909.

Council of Science Editors:

Caldwell LJ. Regeneration of dopaminergic neurons and other neuronal cell types in zebrafish. [Doctoral Dissertation]. University of Edinburgh; 2019. Available from: http://hdl.handle.net/1842/35909

University of Edinburgh

18. Carbone, Benedetta. Characterising the in vitro conversion of mouse fibroblasts into induced neurons using a CRISPR/Cas9 knock-out screen.

Degree: PhD, 2020, University of Edinburgh

URL: http://hdl.handle.net/1842/36981

► As the global phenomenon of population aging has become very prominent in the last few decades, diseases of the aging such as Alzheimer’s and Parkinson’s… (more)

▼ As the global phenomenon of population aging has become very prominent in the last few decades, diseases of the aging such as Alzheimer’s and Parkinson’s disease have taken the spotlight as the new challenges of modern medicine. In fact, aging is the biggest risk factor for neurodegeneration. Neurodegenerative diseases are particularly difficult to study, as animal models often fail to recapitulate human disease phenotypes, together with the challenging aspects of monitoring cognitive functions in smaller animals. Thanks to stem cell research, we’re now able to derive large quantities of human neurons in vitro. This has been incredibly helpful for neuroscientific research, but stem cell-derived neurons show cellular and molecular features, such as epigenetic characteristics and metabolic activity, that resemble embryonic neurons and thus fail to recapitulate the damage and oxidative stress typical of aged neurons. In 2010 the first report of in vitro fibroblast-derived neurons opened the way for an alternative source of neurons, that could easily be derived from individual patients, and most importantly maintain the cellular age of the original fibroblasts. This presents then as a better tool to study diseases that affect aged neurons in vitro. The conversion process is nonetheless quite inefficient and leads to a very heterogeneous mix of cell types, in which a limited number of induced neurons would need to be isolated from contaminating fibroblasts, myoblasts and cells of uncharacterized subtypes. In this thesis I describe my efforts to identify the drivers of the reprogramming process that lead to a successful conversion from a fibroblast to a neuron, and the roadblocks that might be hindering it. To achieve this, I decided to take a genetic screening approach, taking advantage of the emerging CRISPR/Cas9 technology that has made genetic knock-outs relatively easy and quick to achieve. By converting Cas9-expessing mouse embryonic fibroblasts (MEFs) into induced neurons (iN) while expressing target gRNAs, I performed a loss-of-function screen to identify genes involved in the conversion process. I first identified a genetic reporter that allows me to isolate the induced neurons from the remaining cell types in the heterogeneous culture. I then selected a subset of genes within the mouse genome as likely candidates to be involved in the cell identity conversion and then proceeded to perform the screen. I identified two genes, Stxbp1 and Sf3a1, as required for iN conversion and survival in the conversion context. Stxbp1 is known to be required for neuronal survival, as its knock-out prevents neurotransmitter release and leads to neuronal death. This thus represents confirmation that iN are a reliable platform to study neuron biology. Sf3a1 is part of the SF3A complex involved in pre-mRNA splicing and has previously been reported to be required for cell identity transitions, but, to the best of my knowledge, had yet not been associated with cell survival in the context of fibroblast to neuron conversion. This work…

Subjects/Keywords: neurons; in vitro fibroblast-derived neurons; CRISPR/Cas9; induced neurons; Stxbp1; Sf3a1

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Carbone, B. (2020). Characterising the in vitro conversion of mouse fibroblasts into induced neurons using a CRISPR/Cas9 knock-out screen. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/36981

Chicago Manual of Style (16^th Edition):

Carbone, Benedetta. “Characterising the in vitro conversion of mouse fibroblasts into induced neurons using a CRISPR/Cas9 knock-out screen.” 2020. Doctoral Dissertation, University of Edinburgh. Accessed April 10, 2021. http://hdl.handle.net/1842/36981.

MLA Handbook (7^th Edition):

Carbone, Benedetta. “Characterising the in vitro conversion of mouse fibroblasts into induced neurons using a CRISPR/Cas9 knock-out screen.” 2020. Web. 10 Apr 2021.

Vancouver:

Carbone B. Characterising the in vitro conversion of mouse fibroblasts into induced neurons using a CRISPR/Cas9 knock-out screen. [Internet] [Doctoral dissertation]. University of Edinburgh; 2020. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1842/36981.

Council of Science Editors:

Carbone B. Characterising the in vitro conversion of mouse fibroblasts into induced neurons using a CRISPR/Cas9 knock-out screen. [Doctoral Dissertation]. University of Edinburgh; 2020. Available from: http://hdl.handle.net/1842/36981

University of Edinburgh

19. Carbone, Benedetta. Characterising the in vitro conversion of mouse fibroblasts into induced neurons using a CRISPR/Cas9 knock-out screen.

Degree: PhD, 2020, University of Edinburgh

URL: https://doi.org/10.7488/era/282 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.806191

► As the global phenomenon of population aging has become very prominent in the last few decades, diseases of the aging such as Alzheimer’s and Parkinson’s… (more)

▼ As the global phenomenon of population aging has become very prominent in the last few decades, diseases of the aging such as Alzheimer’s and Parkinson’s disease have taken the spotlight as the new challenges of modern medicine. In fact, aging is the biggest risk factor for neurodegeneration. Neurodegenerative diseases are particularly difficult to study, as animal models often fail to recapitulate human disease phenotypes, together with the challenging aspects of monitoring cognitive functions in smaller animals. Thanks to stem cell research, we’re now able to derive large quantities of human neurons in vitro. This has been incredibly helpful for neuroscientific research, but stem cell-derived neurons show cellular and molecular features, such as epigenetic characteristics and metabolic activity, that resemble embryonic neurons and thus fail to recapitulate the damage and oxidative stress typical of aged neurons. In 2010 the first report of in vitro fibroblast-derived neurons opened the way for an alternative source of neurons, that could easily be derived from individual patients, and most importantly maintain the cellular age of the original fibroblasts. This presents then as a better tool to study diseases that affect aged neurons in vitro. The conversion process is nonetheless quite inefficient and leads to a very heterogeneous mix of cell types, in which a limited number of induced neurons would need to be isolated from contaminating fibroblasts, myoblasts and cells of uncharacterized subtypes. In this thesis I describe my efforts to identify the drivers of the reprogramming process that lead to a successful conversion from a fibroblast to a neuron, and the roadblocks that might be hindering it. To achieve this, I decided to take a genetic screening approach, taking advantage of the emerging CRISPR/Cas9 technology that has made genetic knock-outs relatively easy and quick to achieve. By converting Cas9-expessing mouse embryonic fibroblasts (MEFs) into induced neurons (iN) while expressing target gRNAs, I performed a loss-of-function screen to identify genes involved in the conversion process. I first identified a genetic reporter that allows me to isolate the induced neurons from the remaining cell types in the heterogeneous culture. I then selected a subset of genes within the mouse genome as likely candidates to be involved in the cell identity conversion and then proceeded to perform the screen. I identified two genes, Stxbp1 and Sf3a1, as required for iN conversion and survival in the conversion context. Stxbp1 is known to be required for neuronal survival, as its knock-out prevents neurotransmitter release and leads to neuronal death. This thus represents confirmation that iN are a reliable platform to study neuron biology. Sf3a1 is part of the SF3A complex involved in pre-mRNA splicing and has previously been reported to be required for cell identity transitions, but, to the best of my knowledge, had yet not been associated with cell survival in the context of fibroblast to neuron conversion. This work…

Subjects/Keywords: neurons; in vitro fibroblast-derived neurons; CRISPR/Cas9; induced neurons; Stxbp1; Sf3a1

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APA (6^th Edition):

Carbone, B. (2020). Characterising the in vitro conversion of mouse fibroblasts into induced neurons using a CRISPR/Cas9 knock-out screen. (Doctoral Dissertation). University of Edinburgh. Retrieved from https://doi.org/10.7488/era/282 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.806191

Chicago Manual of Style (16^th Edition):

Carbone, Benedetta. “Characterising the in vitro conversion of mouse fibroblasts into induced neurons using a CRISPR/Cas9 knock-out screen.” 2020. Doctoral Dissertation, University of Edinburgh. Accessed April 10, 2021. https://doi.org/10.7488/era/282 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.806191.

MLA Handbook (7^th Edition):

Carbone, Benedetta. “Characterising the in vitro conversion of mouse fibroblasts into induced neurons using a CRISPR/Cas9 knock-out screen.” 2020. Web. 10 Apr 2021.

Vancouver:

Carbone B. Characterising the in vitro conversion of mouse fibroblasts into induced neurons using a CRISPR/Cas9 knock-out screen. [Internet] [Doctoral dissertation]. University of Edinburgh; 2020. [cited 2021 Apr 10]. Available from: https://doi.org/10.7488/era/282 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.806191.

Council of Science Editors:

Carbone B. Characterising the in vitro conversion of mouse fibroblasts into induced neurons using a CRISPR/Cas9 knock-out screen. [Doctoral Dissertation]. University of Edinburgh; 2020. Available from: https://doi.org/10.7488/era/282 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.806191

Ryerson University

20. McGarry, Lucy M. J. The role of the mirror neuron system in bottom-up and top-down perception of human action.

Degree: 2015, Ryerson University

URL: https://digital.library.ryerson.ca/islandora/object/RULA%3A3796

► When we see or hear another person execute an action, we tend to automatically simulate that action. Evidence for this has been found at the… (more)

Subjects/Keywords: Mirror neurons; Human behavior

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APA (6^th Edition):

McGarry, L. M. J. (2015). The role of the mirror neuron system in bottom-up and top-down perception of human action. (Thesis). Ryerson University. Retrieved from https://digital.library.ryerson.ca/islandora/object/RULA%3A3796

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McGarry, Lucy M J. “The role of the mirror neuron system in bottom-up and top-down perception of human action.” 2015. Thesis, Ryerson University. Accessed April 10, 2021. https://digital.library.ryerson.ca/islandora/object/RULA%3A3796.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McGarry, Lucy M J. “The role of the mirror neuron system in bottom-up and top-down perception of human action.” 2015. Web. 10 Apr 2021.

Vancouver:

McGarry LMJ. The role of the mirror neuron system in bottom-up and top-down perception of human action. [Internet] [Thesis]. Ryerson University; 2015. [cited 2021 Apr 10]. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A3796.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McGarry LMJ. The role of the mirror neuron system in bottom-up and top-down perception of human action. [Thesis]. Ryerson University; 2015. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A3796

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Rochester

21. Yunes-Medina, Laura. The Role of Transglutaminase 2 in Neuronal Viability.

Degree: PhD, 2018, University of Rochester

URL: http://hdl.handle.net/1802/33408

► Neuronal viability is dependent on various pathways induced by the extracellular environment. If these pathways are disturbed neurons are more susceptible to injury. A protein… (more)

Subjects/Keywords: Transglutaminase 2; Hypoxia; Neurons

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APA (6^th Edition):

Yunes-Medina, L. (2018). The Role of Transglutaminase 2 in Neuronal Viability. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/33408

Chicago Manual of Style (16^th Edition):

Yunes-Medina, Laura. “The Role of Transglutaminase 2 in Neuronal Viability.” 2018. Doctoral Dissertation, University of Rochester. Accessed April 10, 2021. http://hdl.handle.net/1802/33408.

MLA Handbook (7^th Edition):

Yunes-Medina, Laura. “The Role of Transglutaminase 2 in Neuronal Viability.” 2018. Web. 10 Apr 2021.

Vancouver:

Yunes-Medina L. The Role of Transglutaminase 2 in Neuronal Viability. [Internet] [Doctoral dissertation]. University of Rochester; 2018. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1802/33408.

Council of Science Editors:

Yunes-Medina L. The Role of Transglutaminase 2 in Neuronal Viability. [Doctoral Dissertation]. University of Rochester; 2018. Available from: http://hdl.handle.net/1802/33408

University of Tasmania

22. Taylor, Bruce Vivian McArthur. The clinical & laboratory delineation of the syndrome of multifocal motor neuropathy with conduction block.

Degree: 2000, University of Tasmania

URL: https://eprints.utas.edu.au/22057/1/whole_TaylorBruceVivianMcArthur2000_thesis.pdf

Subjects/Keywords: Motor neurons

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APA (6^th Edition):

Taylor, B. V. M. (2000). The clinical & laboratory delineation of the syndrome of multifocal motor neuropathy with conduction block. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/22057/1/whole_TaylorBruceVivianMcArthur2000_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Taylor, Bruce Vivian McArthur. “The clinical & laboratory delineation of the syndrome of multifocal motor neuropathy with conduction block.” 2000. Thesis, University of Tasmania. Accessed April 10, 2021. https://eprints.utas.edu.au/22057/1/whole_TaylorBruceVivianMcArthur2000_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Taylor, Bruce Vivian McArthur. “The clinical & laboratory delineation of the syndrome of multifocal motor neuropathy with conduction block.” 2000. Web. 10 Apr 2021.

Vancouver:

Taylor BVM. The clinical & laboratory delineation of the syndrome of multifocal motor neuropathy with conduction block. [Internet] [Thesis]. University of Tasmania; 2000. [cited 2021 Apr 10]. Available from: https://eprints.utas.edu.au/22057/1/whole_TaylorBruceVivianMcArthur2000_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Taylor BVM. The clinical & laboratory delineation of the syndrome of multifocal motor neuropathy with conduction block. [Thesis]. University of Tasmania; 2000. Available from: https://eprints.utas.edu.au/22057/1/whole_TaylorBruceVivianMcArthur2000_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Anita Rajah. The effect of a computer-aided cognitive enrichment programme on the scholastic performance of children: an exploratory study; -.

Degree: Clinical Psychology, 2012, Amrita Vishwa Vidyapeetham (University)

URL: http://shodhganga.inflibnet.ac.in/handle/10603/5704

►

Childhood is one of the most challenging stages of human life, characterized by constant growth and development- physically and psychologically. The normal growth and development… (more)

▼

Childhood is one of the most challenging stages of human life, characterized by constant growth and development- physically and psychologically. The normal growth and development of the brain occurs in parallel with the growth and development of cognitive functions. Atypical brain development may cause deficits in neuropsychological functions, resulting in academic difficulties. Attention, information processing and working memory are 3 functions that have been associated with scholastic problems in children. The lack of clarity in defining learning difficulty may lead to under-diagnosis of the problem in children and therefore, denial of possible help. Identifying children at risk and providing general intervention could be a model for prevention adopted in the Indian context. Average scholastic performance in lower classes can be a sign of risk for future difficulties in learning. Computer based interventions have scope for great use for children . Cogmed (for working memory) and FastForWord (for phonological processing) are 2 computer based programmes that have been repeatedly used with promising results. The Brain Functions Therapy(BFT), a computer-based programme developed in India, has been used in this study. This intervention targets core functions such as visuo-spatial processing, attention, working memory and response inhibition, which in turn contribute to intellectual and academic skills. The aim of the study was to assess the effectiveness of the BFT on the scholastic performance of children in classes 3, 4 and 5. The objectives of the study were to identify children with average scholastic performance in these classes, and assess their intellectual, academic and behavioural profile. The other objective was to find out the impact of the cognitive enrichment programme on the scholasticperformance, intellectual functioning and behaviour of these children. A before-after experimental design with controls was adopted for the present study.

References p.109-129, appendices include

Advisors/Committee Members: Anandkumar, A, Sundaram, K R.

Subjects/Keywords: Clinical Psychology; Brain; Neurons

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APA (6^th Edition):

Rajah, A. (2012). The effect of a computer-aided cognitive enrichment programme on the scholastic performance of children: an exploratory study; -. (Thesis). Amrita Vishwa Vidyapeetham (University). Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/5704

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rajah, Anita. “The effect of a computer-aided cognitive enrichment programme on the scholastic performance of children: an exploratory study; -.” 2012. Thesis, Amrita Vishwa Vidyapeetham (University). Accessed April 10, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/5704.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rajah, Anita. “The effect of a computer-aided cognitive enrichment programme on the scholastic performance of children: an exploratory study; -.” 2012. Web. 10 Apr 2021.

Vancouver:

Rajah A. The effect of a computer-aided cognitive enrichment programme on the scholastic performance of children: an exploratory study; -. [Internet] [Thesis]. Amrita Vishwa Vidyapeetham (University); 2012. [cited 2021 Apr 10]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/5704.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rajah A. The effect of a computer-aided cognitive enrichment programme on the scholastic performance of children: an exploratory study; -. [Thesis]. Amrita Vishwa Vidyapeetham (University); 2012. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/5704

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Queens University

24. Groten, Christopher. The Regulation of Intracellular Ca2+ and Secretion in the Bag Cell Neurons of Aplysia Californica .

Degree: Physiology, 2015, Queens University

URL: http://hdl.handle.net/1974/13529

► Neurons enter states of heightened excitability and secretory capacity to initiate fundamental behaviours. This is exemplified by the bag cell neurons of the marine mollusc,… (more)

▼ Neurons enter states of heightened excitability and secretory capacity to initiate fundamental behaviours. This is exemplified by the bag cell neurons of the marine mollusc, Aplysia californica. These neuroendocrine cells undergo an afterdischarge to secrete egg-laying hormone (ELH) and initiate reproduction. I examined the role of two cellular signaling pathways that contribute to the afterdischarge: Ca2+ and protein kinase C (PKC). Investigating these systems provides insight into the cellular mechanisms underlying fundamental behaviours. Intracellular Ca2+ modulates excitability and initiates secretion in the bag cell neurons. I determined how Ca2+ sources and removal systems control intracellular Ca2+. My data revealed that the mitochondria strongly influence Ca2+ signaling in cultured bag cell neurons, as they first buffer voltage-gated Ca2+ influx and subsequently release Ca2+ to the cytosol, in a form of Ca2+-induced Ca2+ release (CICR). Moreover, the degree of mitochondrial Ca2+ uptake and release was shown to be dictated by the function of the plasma membrane Ca2+ ATPase. In addition to voltage-gated Ca2+ influx, I characterized the involvement of Ca2+ handling systems with other distinct Ca2+ sources, including CICR and the Na+/Ca2+ exchanger as well as store-operated Ca2+ influx and the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA). PKC is implicated in facilitating secretion during the afterdischarge. I tested the impact of PKC on secretion using capacitance tracking under whole-cell voltage-clamp. This technique assays the changes in plasma membrane area that occur during vesicle exocytosis. I demonstrated that PKC activation enhanced Ca2+ influx and potentiated stimulus-evoked secretion. This occurred as a result of the plasma membrane insertion of a covert voltage-gated Ca2+ channel, Apl Cav2, alongside the basal voltage-gated Ca2+ channel, Apl Cav1. iii I provided mechanistic detail of how the interplay between Ca2+ sources and removal systems governs the patterns of free cytosolic Ca2+. These properties have implications for the Ca2+-dependent signaling pathways which mediate long lasting changes in neuronal excitability and secretion. Furthermore, my work demonstrates that protein kinases can dynamically amplify secretory output by rapidly recruiting additional voltage-gated Ca2+ channels to the membrane. This form of facilitation likely enhances secretion during the afterdischarge, and ensures the initiation of reproductive behaviour in Aplysia.

Subjects/Keywords: Bag Cell Neurons ; Afterdischarge

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APA (6^th Edition):

Groten, C. (2015). The Regulation of Intracellular Ca2+ and Secretion in the Bag Cell Neurons of Aplysia Californica . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/13529

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Groten, Christopher. “The Regulation of Intracellular Ca2+ and Secretion in the Bag Cell Neurons of Aplysia Californica .” 2015. Thesis, Queens University. Accessed April 10, 2021. http://hdl.handle.net/1974/13529.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Groten, Christopher. “The Regulation of Intracellular Ca2+ and Secretion in the Bag Cell Neurons of Aplysia Californica .” 2015. Web. 10 Apr 2021.

Vancouver:

Groten C. The Regulation of Intracellular Ca2+ and Secretion in the Bag Cell Neurons of Aplysia Californica . [Internet] [Thesis]. Queens University; 2015. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1974/13529.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Groten C. The Regulation of Intracellular Ca2+ and Secretion in the Bag Cell Neurons of Aplysia Californica . [Thesis]. Queens University; 2015. Available from: http://hdl.handle.net/1974/13529

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Loughborough University

25. Pardo-Figuerez, Maria M. Designing neuronal networks with chemically modified substrates : an improved approach to conventional in vitro neural systems.

Degree: PhD, 2018, Loughborough University

URL: http://hdl.handle.net/2134/27941

► Highly organised structures have been well-known to be part of the complex neuronal network presented in the nervous system, where thousands of neuronal connections are… (more)

▼ Highly organised structures have been well-known to be part of the complex neuronal network presented in the nervous system, where thousands of neuronal connections are arranged to give rise to critical physiological functions. Conventional in vitro culture methods are useful to represent simplistic neuronal behaviour, however, the lack of such organisation results in random and uncontrolled neurite spreading, leading to a lack of cell directionality and in turn, resulting in inaccurate neuronal in vitro models. Neurons are highly specialised cells, known to be greatly dependent on interactions with their surroundings. Therefore, when surface material is modified, drastic changes in neuronal behaviour can be achieved. The use of chemically modified surfaces in vitro has opened new avenues in cell culture, where the chaotic environment found in conventional culture methods can be controlled by the combination of surface modification methods with surface engineering techniques. Polymer brushes and self-assembled monolayers (SAMs) display a wide range of advantages as a surface modification tool for cell culture applications, since their properties can be finely tuned to promote or inhibit cellular adhesion, differentiation and proliferation. Therefore, when precisely combined with patterning techniques, a control over neuronal behaviour can be achieved. Neuronal patterning presents a system with instructive cues that can be used to study neuron-neuron communication by directing single neurites in specific locations to initiate synapses. Furthermore, although this area has not been much explored, the use of these patterned brushes could also be used in co-culture systems as a platform to closely monitor cell heterotypical communication. This research demonstrates the behaviour of SH-SY5Y neurons on a variety of SAMs and polymer brushes, both in isolation and combination to promote cellular spatial control. APTES and BIBB coatings promoted the highest cell viability, proliferation, metabolic activity and neuronal maturation, whilst low cell adhesion was seen on PKSPMA and PMETAC surfaces. Thereafter, PKSPMA brushes were used as a potential cell repulsive coating and its combination with micro- patterning techniques (photolithography and soft lithography) resulted in a system with instructive cues for neuronal guidance, where neuronal directionality was obtained. In the final chapter of this thesis, a chimeric co-culture system was developed where the patterned SH-SY5Y cells were co-cultured with C2C12 myoblasts in an attempt to obtain an organised neuronal-muscle co-culture system. Whilst preliminary observations showed first stages of a patterned neuronal-muscle co-culture, future work is necessary to refine and improve the patterned co-culture process.

Subjects/Keywords: 612.8; Polymer brushes; SAMs; Neurons

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pardo-Figuerez, M. M. (2018). Designing neuronal networks with chemically modified substrates : an improved approach to conventional in vitro neural systems. (Doctoral Dissertation). Loughborough University. Retrieved from http://hdl.handle.net/2134/27941

Chicago Manual of Style (16^th Edition):

Pardo-Figuerez, Maria M. “Designing neuronal networks with chemically modified substrates : an improved approach to conventional in vitro neural systems.” 2018. Doctoral Dissertation, Loughborough University. Accessed April 10, 2021. http://hdl.handle.net/2134/27941.

MLA Handbook (7^th Edition):

Pardo-Figuerez, Maria M. “Designing neuronal networks with chemically modified substrates : an improved approach to conventional in vitro neural systems.” 2018. Web. 10 Apr 2021.

Vancouver:

Pardo-Figuerez MM. Designing neuronal networks with chemically modified substrates : an improved approach to conventional in vitro neural systems. [Internet] [Doctoral dissertation]. Loughborough University; 2018. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/2134/27941.

Council of Science Editors:

Pardo-Figuerez MM. Designing neuronal networks with chemically modified substrates : an improved approach to conventional in vitro neural systems. [Doctoral Dissertation]. Loughborough University; 2018. Available from: http://hdl.handle.net/2134/27941

Columbia University

26. Elsayed, Gamaleldin Fathy. Identification and Validation of Structures in Neural Population Responses.

Degree: 2017, Columbia University

URL: https://doi.org/10.7916/D8G73S1W

► A fundamental challenge of neuroscience is to understand how interconnected populations of neurons give rise to the remarkable computational abilities of our brains. Large neural… (more)

Subjects/Keywords: Neurosciences; Electrical engineering; Statistics; Neurons

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APA (6^th Edition):

Elsayed, G. F. (2017). Identification and Validation of Structures in Neural Population Responses. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8G73S1W

Chicago Manual of Style (16^th Edition):

Elsayed, Gamaleldin Fathy. “Identification and Validation of Structures in Neural Population Responses.” 2017. Doctoral Dissertation, Columbia University. Accessed April 10, 2021. https://doi.org/10.7916/D8G73S1W.

MLA Handbook (7^th Edition):

Elsayed, Gamaleldin Fathy. “Identification and Validation of Structures in Neural Population Responses.” 2017. Web. 10 Apr 2021.

Vancouver:

Elsayed GF. Identification and Validation of Structures in Neural Population Responses. [Internet] [Doctoral dissertation]. Columbia University; 2017. [cited 2021 Apr 10]. Available from: https://doi.org/10.7916/D8G73S1W.

Council of Science Editors:

Elsayed GF. Identification and Validation of Structures in Neural Population Responses. [Doctoral Dissertation]. Columbia University; 2017. Available from: https://doi.org/10.7916/D8G73S1W

Columbia University

27. Jacko, Martin. Rbfox splicing factors promote neuronal maturation and axon initial segment assembly.

Degree: 2017, Columbia University

URL: https://doi.org/10.7916/D8K07GKC

► The Rbfox proteins are a family of splicing regulators in post-mitotic neurons, predicted to be required for control of hundreds of alternative exons in neuronal… (more)

Subjects/Keywords: Neurosciences; Molecular biology; Neurons

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jacko, M. (2017). Rbfox splicing factors promote neuronal maturation and axon initial segment assembly. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8K07GKC

Chicago Manual of Style (16^th Edition):

Jacko, Martin. “Rbfox splicing factors promote neuronal maturation and axon initial segment assembly.” 2017. Doctoral Dissertation, Columbia University. Accessed April 10, 2021. https://doi.org/10.7916/D8K07GKC.

MLA Handbook (7^th Edition):

Jacko, Martin. “Rbfox splicing factors promote neuronal maturation and axon initial segment assembly.” 2017. Web. 10 Apr 2021.

Vancouver:

Jacko M. Rbfox splicing factors promote neuronal maturation and axon initial segment assembly. [Internet] [Doctoral dissertation]. Columbia University; 2017. [cited 2021 Apr 10]. Available from: https://doi.org/10.7916/D8K07GKC.

Council of Science Editors:

Jacko M. Rbfox splicing factors promote neuronal maturation and axon initial segment assembly. [Doctoral Dissertation]. Columbia University; 2017. Available from: https://doi.org/10.7916/D8K07GKC

Columbia University

28. Sippy, Tanya. Asynchronous Inhibition in Neocortical Microcircuits.

Degree: 2011, Columbia University

URL: https://doi.org/10.7916/D8V70RDP

► Neurons are constantly integrating information from external and internal sources, causing them to spike at particular times. The exact timing of spikes is determined by… (more)

▼ Neurons are constantly integrating information from external and internal sources, causing them to spike at particular times. The exact timing of spikes is determined by a neuron's intrinsic properties, as well as the interplay between local excitatory and inhibitory inputs. Although inhibitory interneurons have been extensively studied, their contribution to neuronal integration and spike timing remains poorly understood. To elucidate the functional role of GABAergic interneurons during cortical activity, we combined molecular identification of interneurons, two photon imaging and electrophysiological recordings in mouse thalamocortical slices. In this preparation, cortical UP states, a network state characterized by prolonged periods of depolarization and synchronized spiking, can be evoked by thalamic stimulation and can also occur spontaneously. To assay the role of inhibition, we first characterized the firing properties of Parvalbumin (PV) and Somatostatin (SOM) interneurons during UP states activity, and found a higher probability and rate of spiking in these two subtypes compared to excitatory cells. These subtypes did not display differential timing of activation during the evoked response. Furthermore, calcium imaging showed low correlations among PV and SOM interneurons, indicating that neurons sharing these neurochemical markers do not coordinate their firing. Intracellular recordings confirmed that nearby interneurons, known to be electrically coupled, do not display more synchronous spiking than excitatory cells, suggesting that this coupling may not function to synchronize the activity of interneurons on fast time scales¬¬¬. After characterizing inhibitory interneuron outputs, we next studied the timing and correlation of inhibitory inputs, which we isolated from excitatory inputs by voltage clamping at the reversal for excitation (0mV) or inhibition (-70mV). In both thalamically triggered and spontaneous activations, IPSCs between cell pairs were remarkably well correlated, with correlation coefficients reaching over .9 in some cases. This high degree of correlation has previously been assumed to be due to interneuron synchrony, but our population imaging and paired recordings did not support this view. In addition, we found that the connection rate between interneurons is very high (~80%), and quantal analysis revealed that each IPSC recorded in neighboring cells during an UP state could be due to a single presynaptic interneuron. Therefore, we explain the high IPSCs correlations in nearby pyramidal cells are emerging from the common input from individual interneurons, rather than from synchronization of interneuron activity across the population. In a final set of experiments, we found that a partial pharmacological block of inhibitory signaling increased EPSC correlations. Our data support a model in which inhibitory neurons do not fire in a correlated fashion but have strong, dense connections to pyramidal neurons that serve to prevent local excitatory synchrony during UP states.…

Subjects/Keywords: Neurosciences; Neurons; Interneurons; Neurobiology; Inhibition

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sippy, T. (2011). Asynchronous Inhibition in Neocortical Microcircuits. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8V70RDP

Chicago Manual of Style (16^th Edition):

Sippy, Tanya. “Asynchronous Inhibition in Neocortical Microcircuits.” 2011. Doctoral Dissertation, Columbia University. Accessed April 10, 2021. https://doi.org/10.7916/D8V70RDP.

MLA Handbook (7^th Edition):

Sippy, Tanya. “Asynchronous Inhibition in Neocortical Microcircuits.” 2011. Web. 10 Apr 2021.

Vancouver:

Sippy T. Asynchronous Inhibition in Neocortical Microcircuits. [Internet] [Doctoral dissertation]. Columbia University; 2011. [cited 2021 Apr 10]. Available from: https://doi.org/10.7916/D8V70RDP.

Council of Science Editors:

Sippy T. Asynchronous Inhibition in Neocortical Microcircuits. [Doctoral Dissertation]. Columbia University; 2011. Available from: https://doi.org/10.7916/D8V70RDP

University of Manitoba

29. Habash, Tarek. Interleukin-17A (IL-17A) enhances axonal regeneration and mitochondrial function of normal and diabetic sensory neurons.

Degree: Pharmacology and Therapeutics, 2014, University of Manitoba

URL: http://hdl.handle.net/1993/23900

► Rationale and hypothesis: Diabetic neuropathy involves dying back of nerve endings that reflects impairment in axonal plasticity and regenerative nerve growth. Metabolic changes in diabetes… (more)

▼ Rationale and hypothesis: Diabetic neuropathy involves dying back of nerve endings that reflects impairment in axonal plasticity and regenerative nerve growth. Metabolic changes in diabetes can lead to a dysregulation of hormonal mediators, such as cytokines. Thus I studied the effect of interleukin-17A (IL-17A), a proinflammatory cytokine produced by T-cells, on the phenotype of sensory neurons derived from control or diabetic rats. I hypothesized that IL-17A induces neurite outgrowth in sensory neurons through signaling pathways that enhance mitochondrial function. IL-17A can also reverse impaired nerve regeneration associated with diabetes Objectives: Determine the ability of IL-17A to enhance neurite outgrowth in cultured sensory neurons. Investigate the signalling pathways activated by IL-17A and mechanistically link to neurite outgrowth. Study the ability of IL-17A to improve mitochondrial function of sensory neurons (since axon outgrowth consumes high levels of ATP). Methodology: Cultured adult dorsal root ganglia (DRG) sensory neurons derived from age matched control or streptozotocin (STZ)-induced type 1 diabetic rats were fixed and stained for fluorescent imaging to determine total neurite outgrowth. Western blotting determined the levels of MAPK and PI-3K activation by IL-17A and for measuring levels of proteins of mitochondrial oxidative phosphorylation pathway. Mitochondrial bioenergetic function was tested in cultured DRG neurons using the Seahorse XF Analyzer. Results: I found that IL-17A (10 ng/ml; P<0.05) significantly increased total neurite outgrowth in cultures derived from both control and STZ-diabetic rat models. This enhancement was mediated by IL-17A-dependent activation of MAPK and PI-3K pathways with maximal effect at 15 minutes (P<0.05). Pharmacological blockade of one of these activated pathways led to total inhibition of neurite outgrowth. IL-17A improved mitochondrial bioenergetic function of sensory neurons. Bioenergetics function was associated with augmented expression of proteins of mitochondrial oxidative phosphorylation. Conclusion: IL-17A enhanced axonal plasticity through activation of MAPK and PI-3K pathways and was associated with augmented mitochondrial bioenergetics function in sensory neurons Advisors/Committee Members: Fernyhough, Paul (Pharmacology and Therapeutics) (supervisor), Albensi, Benedict (Pharmacology and Therapeutics) Czubryt, Michael (Physiology) (examiningcommittee).

Subjects/Keywords: Diabetes; Neuropathy; Sensory; Neurons; Mitochondria

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APA (6^th Edition):

Habash, T. (2014). Interleukin-17A (IL-17A) enhances axonal regeneration and mitochondrial function of normal and diabetic sensory neurons. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/23900

Chicago Manual of Style (16^th Edition):

Habash, Tarek. “Interleukin-17A (IL-17A) enhances axonal regeneration and mitochondrial function of normal and diabetic sensory neurons.” 2014. Masters Thesis, University of Manitoba. Accessed April 10, 2021. http://hdl.handle.net/1993/23900.

MLA Handbook (7^th Edition):

Habash, Tarek. “Interleukin-17A (IL-17A) enhances axonal regeneration and mitochondrial function of normal and diabetic sensory neurons.” 2014. Web. 10 Apr 2021.

Vancouver:

Habash T. Interleukin-17A (IL-17A) enhances axonal regeneration and mitochondrial function of normal and diabetic sensory neurons. [Internet] [Masters thesis]. University of Manitoba; 2014. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1993/23900.

Council of Science Editors:

Habash T. Interleukin-17A (IL-17A) enhances axonal regeneration and mitochondrial function of normal and diabetic sensory neurons. [Masters Thesis]. University of Manitoba; 2014. Available from: http://hdl.handle.net/1993/23900

University of Washington

30. Gan, Jerilyn. Dissociable Cost and Benefit Encoding of Future Rewards by Mesolimbic Dopamine.

Degree: 2011, University of Washington

URL: http://hdl.handle.net/1773/17088

► Dopamine is a neural substrate implicated in the complex computation of weighing the costs and benefits of future actions. Midbrain dopamine neurons encode fundamental economic… (more)

▼ Dopamine is a neural substrate implicated in the complex computation of weighing the costs and benefits of future actions. Midbrain dopamine neurons encode fundamental economic parameters pertaining to predicted rewards in their subsecond firing pattern and innervate areas that have been implicated in economic decision-making such as the nucleus accumbens. Disruptions of dopamine in the nucleus accumbens core (NAcc) diminish animals’ ability to respond to cues and overcome effortful response costs. However, electrolytic and chemical depletions of dopamine disrupt more than just the subsecond dopamine signal shown to encode economic parameters. Thus, to deconstruct the nature of the signal transmitted by phasic dopamine to the NAcc, new technology to detect dopamine at a subsecond time scale viable over months needs be developed. With this new technology we may characterized how subsecond dopamine accounts for behaviors by determining how it reacts to changes in anticipated costs and benefits. Part I of this thesis will discuss dopamine in general. I will discuss dopamine as a neurochemical, anatomy of the dopaminergic systems involved with decision making, and dopamine neuron firing patterns. I will briefly review some theories of dopamine’s role in behavior, with attention to dopamine’s role in decision making. In Part II, I discuss the development and characterization of chronically implantable fast-scan cyclic voltammetry (FSCV) microsensors. Though in vitro validation of these electrodes was performed, I will primarily describe the in vivo validation of these electrodes in this thesis. With the advent of these electrodes, we extend the ability to detect subsecond dopamine transmission in awake, behaving animals from a handful of recordings to a multitude of recordings across months. In Part III, we examine the valuation signal transmitted by phasic dopamine in the NAcc. Animals implanted with chronic FSCV microsensors were asked to distinguish cues that predicted either differing amounts of food reward or differing efforts (amounts of lever presses). We found that dopamine release in rat nucleus accumbens encodes anticipated benefits, but not effort-based response costs unless they are atypically low. This neural separation of costs and benefits indicates that mesolimbic dopamine scales with the value of pending rewards, but does not encode the net utility of the action to obtain them.

Subjects/Keywords: dopamine neural neurons neurochemical economic

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gan, J. (2011). Dissociable Cost and Benefit Encoding of Future Rewards by Mesolimbic Dopamine. (Thesis). University of Washington. Retrieved from http://hdl.handle.net/1773/17088

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gan, Jerilyn. “Dissociable Cost and Benefit Encoding of Future Rewards by Mesolimbic Dopamine.” 2011. Thesis, University of Washington. Accessed April 10, 2021. http://hdl.handle.net/1773/17088.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gan, Jerilyn. “Dissociable Cost and Benefit Encoding of Future Rewards by Mesolimbic Dopamine.” 2011. Web. 10 Apr 2021.

Vancouver:

Gan J. Dissociable Cost and Benefit Encoding of Future Rewards by Mesolimbic Dopamine. [Internet] [Thesis]. University of Washington; 2011. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1773/17088.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gan J. Dissociable Cost and Benefit Encoding of Future Rewards by Mesolimbic Dopamine. [Thesis]. University of Washington; 2011. Available from: http://hdl.handle.net/1773/17088

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations