subject:(Neuromodulation)

Rice University

1. Wickens, Amanda. Magnetoelectric Materials for Miniature, Wireless Neural Interfaces.

Degree: MS, Natural Sciences, 2018, Rice University

URL: http://hdl.handle.net/1911/105756

► Developments in wireless neuromodulation technologies have lead to new treatments for neurological disorders and new methods of probing neural circuits in humans and animal models.… (more)

Subjects/Keywords: Neuromodulation; Magnetoelectric

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APA (6^th Edition):

Wickens, A. (2018). Magnetoelectric Materials for Miniature, Wireless Neural Interfaces. (Masters Thesis). Rice University. Retrieved from http://hdl.handle.net/1911/105756

Chicago Manual of Style (16^th Edition):

Wickens, Amanda. “Magnetoelectric Materials for Miniature, Wireless Neural Interfaces.” 2018. Masters Thesis, Rice University. Accessed January 23, 2021. http://hdl.handle.net/1911/105756.

MLA Handbook (7^th Edition):

Wickens, Amanda. “Magnetoelectric Materials for Miniature, Wireless Neural Interfaces.” 2018. Web. 23 Jan 2021.

Vancouver:

Wickens A. Magnetoelectric Materials for Miniature, Wireless Neural Interfaces. [Internet] [Masters thesis]. Rice University; 2018. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1911/105756.

Council of Science Editors:

Wickens A. Magnetoelectric Materials for Miniature, Wireless Neural Interfaces. [Masters Thesis]. Rice University; 2018. Available from: http://hdl.handle.net/1911/105756

University of Cambridge

2. Flynn, Sean. Molecular tuning of a neural circuit that drives aggregation behaviour in C. elegans.

Degree: PhD, 2018, University of Cambridge

URL: https://www.repository.cam.ac.uk/handle/1810/273738

► Modulation of network state is a ubiquitous feature of nervous systems. A major challenge in understanding the physiological flexibility of neural circuits is linking molecules… (more)

▼ Modulation of network state is a ubiquitous feature of nervous systems. A major challenge in understanding the physiological flexibility of neural circuits is linking molecules that regulate behaviour to changes in the properties of individual neurons. Here, we use a defined neural circuit in C. elegans to frame this universal problem. By genetic dissection of the behavioural state that sustains escape of 21% O2, we identify novel neuronal functions for several highly conserved genes, including a caspase-like molecule, a calcium-sensitive transcription factor, and two translation initiation factors. These molecules have been implicated in diverse forms of human disease, but their role in the nervous system is either unexplored or poorly understood. Using in vivo Ca2+ imaging techniques to investigate neuron physiology in immobilized and behaving animals, we demonstrate their effect on the properties of individual neurons. The activity of RMG hub neurons is associated with the switch in behavioural state induced by 21% O2. Recently it has been shown that the input-output relationship of RMG is controlled by cytokine signaling, an increasingly appreciated form of neuromodulation. Here I present biochemical and genetic evidence that characterize a novel signaling component downstream of IL-17 receptors in RMG. Our data suggest that, reminiscent of its role in the immune system, it performs both scaffolding and enzymatic functions in neurons. Additionally, we show that RMG responsiveness is controlled by widely expressed, putative regulators of gene expression. Our analyses of these proteins elucidate their function within the URX-RMG circuit, but also raise hypotheses that can be tested more generally in the nervous system. We propose that a calmodulin-binding protein regulates adaptation to ambient O2 conditions, which may reflect a widespread requirement for controlling homeostatic plasticity. Two translation factors that have been shown to be dispensable for general translation are important for regulation of the response to stress. Our study raises the possibility that their role in promoting the activity of all, or some subset of, neurons might underlie this contextual requirement. Together, our findings provide mechanistic insight into the regulation of a behavioural state associated with a specific environmental context.

Subjects/Keywords: neuromodulation; signaling; genetics

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APA (6^th Edition):

Flynn, S. (2018). Molecular tuning of a neural circuit that drives aggregation behaviour in C. elegans. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/273738

Chicago Manual of Style (16^th Edition):

Flynn, Sean. “Molecular tuning of a neural circuit that drives aggregation behaviour in C. elegans.” 2018. Doctoral Dissertation, University of Cambridge. Accessed January 23, 2021. https://www.repository.cam.ac.uk/handle/1810/273738.

MLA Handbook (7^th Edition):

Flynn, Sean. “Molecular tuning of a neural circuit that drives aggregation behaviour in C. elegans.” 2018. Web. 23 Jan 2021.

Vancouver:

Flynn S. Molecular tuning of a neural circuit that drives aggregation behaviour in C. elegans. [Internet] [Doctoral dissertation]. University of Cambridge; 2018. [cited 2021 Jan 23]. Available from: https://www.repository.cam.ac.uk/handle/1810/273738.

Council of Science Editors:

Flynn S. Molecular tuning of a neural circuit that drives aggregation behaviour in C. elegans. [Doctoral Dissertation]. University of Cambridge; 2018. Available from: https://www.repository.cam.ac.uk/handle/1810/273738

University of Illinois – Urbana-Champaign

3. Sipolins, Aldis Gunars. Can high definition transcranial direct current stimulation (HD-tDCS) enhance cognitive training and transfer?.

Degree: PhD, Psychology, 2016, University of Illinois – Urbana-Champaign

URL: http://hdl.handle.net/2142/90476

► The INSIGHT project combines cognitive training with high-definition transcranial direct current stimulation (HD-tDCS) with the goal of enhancing fluid intelligence (Gf) and adaptive problem solving… (more)

▼ The INSIGHT project combines cognitive training with high-definition transcranial direct current stimulation (HD-tDCS) with the goal of enhancing fluid intelligence (Gf) and adaptive problem solving in healthy adults. 129 young to middle-aged subjects completed 20 1hr cognitive training sessions with a videogame called Mind Frontiers while receiving HD-tDCS. Mind Frontiers was developed for the INISGHT project and comprised six adaptively difficult cognitive training tasks. HD-tDCS was applied for 30 minutes (active) or 30 seconds (sham) at 2.0 mA at the start of each training session, with anodes placed bilaterally over the prefrontal cortex. Before and after cognitive training, participants completed a battery of tasks to assess Gf, executive function, working memory, and episodic memory. Participants who received active tDCS showed improved performance on the Mind Frontiers games compared to those who received sham. Transfer to untrained tasks, however, was unaffected; no comparable improvements in transfer from pre- to post-training were observed. Such results provide strong evidence that tDCS can enhance cognitive training performance but no evidence for enhanced transfer of learned skills to untrained tasks. When individual differences were examined, Gf was found to be an effective predictor of trained task improvement and age moderated the beneficial effect of HD-tDCS on training performance, with younger subjects benefitting more than old. An alternative explanation of the results, an acute effect of tDCS on vigilance decrement, was evaluated but evidence was insufficient to draw firm conclusions. To summarize, tDCS appears to be more effective at enhancing performance of specific skills than improving general cognitive abilities, and this effect is stronger in younger adults. Advisors/Committee Members: Kramer, Arthur F (advisor), Kramer, Arthur F (Committee Chair), Barbey, Aron K (committee member), Cohen, Neal J (committee member), Wang, Frances (committee member), Hillman, Charles H (committee member).

Subjects/Keywords: cognitive training; neuromodulation

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APA (6^th Edition):

Sipolins, A. G. (2016). Can high definition transcranial direct current stimulation (HD-tDCS) enhance cognitive training and transfer?. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/90476

Chicago Manual of Style (16^th Edition):

Sipolins, Aldis Gunars. “Can high definition transcranial direct current stimulation (HD-tDCS) enhance cognitive training and transfer?.” 2016. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed January 23, 2021. http://hdl.handle.net/2142/90476.

MLA Handbook (7^th Edition):

Sipolins, Aldis Gunars. “Can high definition transcranial direct current stimulation (HD-tDCS) enhance cognitive training and transfer?.” 2016. Web. 23 Jan 2021.

Vancouver:

Sipolins AG. Can high definition transcranial direct current stimulation (HD-tDCS) enhance cognitive training and transfer?. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2016. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/2142/90476.

Council of Science Editors:

Sipolins AG. Can high definition transcranial direct current stimulation (HD-tDCS) enhance cognitive training and transfer?. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2016. Available from: http://hdl.handle.net/2142/90476

Tampere University

4. Sun, Lihua. Impact of Neuromodulation on Cognitive and Affective Brain Functions in Humans .

Degree: 2016, Tampere University

URL: https://trepo.tuni.fi/handle/10024/99618

► Erilaisten neuromodulaatiotekniikoiden on esitetty korjaavan hermoratojen häiriöitä ja näitä hoitomuotoja käytetäänkin neurologisten ja psykiatristen sairauksien hoidossa. Tässä työssä tutkittuja neuromodulaatiotekniikoita ovat mm. syväaivostimulaatio (Deep Brain… (more)

▼ Erilaisten neuromodulaatiotekniikoiden on esitetty korjaavan hermoratojen häiriöitä ja näitä hoitomuotoja käytetäänkin neurologisten ja psykiatristen sairauksien hoidossa. Tässä työssä tutkittuja neuromodulaatiotekniikoita ovat mm. syväaivostimulaatio (Deep Brain Stimulation, DBS) ja vagushermon stimulaatio (Vagus Nerve Stimulation, VNS) sekä ei-invasiivisena keinona silmänulkoinen valostimulaatio (korvavalo). Monet neuromodulaatiohoidot vaikuttavat tunteista ja tiedonkäsittelystä vastaaviin hermoradastoihin, joten modulaatio vaikuttaa näin ollen myös aivojen tunne- ja tiedonkäsittelytoimintoihin. Tämän väitöskirjan tarkoituksena on selvittää neuromodulaation vaikutuksia ihmisen toiminnanohjaukseen ja tunnetoimintoihin ja tutkia näiden toimintojen taustalla olevia hermoverkostoja. DBS-hoito lisäsi tarkkaavuuden suuntaamista uhkaaviin ärsykkeisiin, mikä nähtiin muutoksina reaktioajoissa ja aivojen fysiologisissa vasteissa. VNS-stimulaation havaittiin parantavan työmuistia ja visuaaliset aivopotentiaalit kasvoivat sopien lisääntyneeseen visuaalisen tarkkaavaisuuteen. Korvavalolla ei havaittu vaikutusta koehenkilöiden kognitiiviseen suorituskykyyn, mutta sillä oli kuitenkin vaikutusta aivojen fysiologiaan uhkaaviin häiriöärsykkeisiin liittyen. Hoitotarkoituksensa lisäksi neuromodulaatiotekniikat antavat täten mahdollisuuden tutkia ihmisen kognition ja tunteiden taustalla olevia hermoverkostoja. Esimerkiksi, tutkimalla DBS:n vaikutuksia, saatiin selville talamuksen etuosan tumakkeen rooli ihmisen tunteiden ja tarkkaavuuden vuorovaikutuksessa.; Neuromodulation techniques have been proposed to restore disrupted neural circuits and are used to treat neurological and psychiatric disorders. The techniques used in the current thesis include deep brain stimulation (DBS), vagus nerve stimulation (VNS) and non-invasive extraocular photomodulation. Many neuromodulation approaches affect cognitive and limbic circuitries, and thus their influence extend to affective and cognitive brain functions. In the study, we used behavioral testing and EEG recording, combined with periodic administration of neuromodulation, to study the immediate effects of neuromodulation on human cognition and emotion. Using these techniques, we found that DBS increased attentional allocation to threat, reflected in behavioral and brain responses. VNS improved working memory performance and increased early visual brain potentials suggesting enhanced visual attention. The ear-canal-delivered extraocular light diminished the modulatory effects of threat-related distractors on brain physiology. Taken together, neuromodulation techniques influenced cognitive and affective brain functions, which should be considered in clinical settings. In addition to their use in medical treatment, these techniques provide unique opportunities to study brain networks underlying human cognition and emotion. For example, DBS treatment allowed us to find the important role of the anterior thalamic nuclei in emotion-attention interaction in humans.

Subjects/Keywords: neuromodulation ; cognition ; emotion ; attention ; EEG

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sun, L. (2016). Impact of Neuromodulation on Cognitive and Affective Brain Functions in Humans . (Doctoral Dissertation). Tampere University. Retrieved from https://trepo.tuni.fi/handle/10024/99618

Chicago Manual of Style (16^th Edition):

Sun, Lihua. “Impact of Neuromodulation on Cognitive and Affective Brain Functions in Humans .” 2016. Doctoral Dissertation, Tampere University. Accessed January 23, 2021. https://trepo.tuni.fi/handle/10024/99618.

MLA Handbook (7^th Edition):

Sun, Lihua. “Impact of Neuromodulation on Cognitive and Affective Brain Functions in Humans .” 2016. Web. 23 Jan 2021.

Vancouver:

Sun L. Impact of Neuromodulation on Cognitive and Affective Brain Functions in Humans . [Internet] [Doctoral dissertation]. Tampere University; 2016. [cited 2021 Jan 23]. Available from: https://trepo.tuni.fi/handle/10024/99618.

Council of Science Editors:

Sun L. Impact of Neuromodulation on Cognitive and Affective Brain Functions in Humans . [Doctoral Dissertation]. Tampere University; 2016. Available from: https://trepo.tuni.fi/handle/10024/99618

University of Saskatchewan

5. Quon, Liz 1991-. Astrocytic involvement in cortical inhibition and serotonin neuromodulation.

Degree: 2016, University of Saskatchewan

URL: http://hdl.handle.net/10388/7410

► A single astrocyte can ensheath more than 100,000 synapses within its domain. Thus, astrocytes are ideally positioned to integrate signals from a few synapses to… (more)

▼ A single astrocyte can ensheath more than 100,000 synapses within its domain. Thus, astrocytes are ideally positioned to integrate signals from a few synapses to have impact on all ensheathed synapses with high efficiency. As neuromodulators are released in a volume manner and are known to illicit astrocyte calcium responses, we hypothesized that astrocytes may be effector cells, extending neuromodulator action to every synapse. Using live mouse brain slices, extracellular recordings of evoked excitatory postsynaptic potentials (eEPSPs), and select pharmacology, we assessed the astrocytic involvement in paired-pulse suppression and serotonin-mediated shaping of a simple sensory cortical network containing both excitatory and inhibitory activity. Using a paired-pulse stimulus repeated every 20 seconds, we assessed the role of astrocytes in paired-pulse suppression by applying pharmacological agents in the bath perfusate to interfere with astrocyte function. We then applied them in the presence of the GABAA antagonist bicuculline to determine if effects were dependent on GABA. To assess the role of astrocytes in serotonin neuromodulation, serotonin was administered as a bolus to the bath perfusate upstream of the recording site to simulate transient effects on the network. Serotonin was applied both before and after bath application of pharmacological agents considered to affect astrocyte function or signaling mechanisms. In the absence of neuromodulators or pharmacological agents, the first cortical eEPSP is much larger in amplitude than the second due to the recruitment of longer-lasting inhibitory activity resulting from the first stimulus. Pharmacological disruption of 1) astrocytic mGluR5 receptors, 2) astrocyte metabolism, 3) gap junctions/hemichannels, or 4) purinergic receptors resulted in a significant loss of this evoked inhibition in field recordings, suggesting that astrocytes may play a role in tonic aspects of network inhibition. Furthermore, all significance was lost when performed in the presence of bicuculline, suggesting that astrocytic involvement in paired-pulse suppression is GABAA dependent. In addition to effects seen on tonic cortical inhibition, serotonin effects on frequency transmission in the cortical network are significantly altered following pharmacological astrocyte disruption. Lastly, serotonin-mediated frequency transmission could also be disrupted using P2 antagonists suggesting that ATP signaling (astrocyte currency) may be involved. These data highlight a potential role for astrocytes in cortical inhibitory activity seen in this sensory cortical network and that serotonin acts on astrocytes to partially exert its modulatory influence. Advisors/Committee Members: Bekar, Lane K, Gopalakrishnan, Venkat, Taghibiglou, Changiz, Walz, Wolfgang.

Subjects/Keywords: Astrocyte; Neuromodulation; Inhibition; Serotonin

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APA (6^th Edition):

Quon, L. 1. (2016). Astrocytic involvement in cortical inhibition and serotonin neuromodulation. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/7410

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Quon, Liz 1991-. “Astrocytic involvement in cortical inhibition and serotonin neuromodulation.” 2016. Thesis, University of Saskatchewan. Accessed January 23, 2021. http://hdl.handle.net/10388/7410.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Quon, Liz 1991-. “Astrocytic involvement in cortical inhibition and serotonin neuromodulation.” 2016. Web. 23 Jan 2021.

Vancouver:

Quon L1. Astrocytic involvement in cortical inhibition and serotonin neuromodulation. [Internet] [Thesis]. University of Saskatchewan; 2016. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10388/7410.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Quon L1. Astrocytic involvement in cortical inhibition and serotonin neuromodulation. [Thesis]. University of Saskatchewan; 2016. Available from: http://hdl.handle.net/10388/7410

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Erasmus University Rotterdam

6. M.C. Verhage (Claire). Neuromodulation of the Cognitive Cerebellum.

Degree: 2018, Erasmus University Rotterdam

URL: http://hdl.handle.net/1765/104022

► In this thesis, the effect of non-invasive neurostimulation on motor and cognitive performance was investigated, taking an implicit-explicit notion into account. Results were mixed, varying… (more)

Subjects/Keywords: tDCS; neuromodulation; neurostimulation; cognition; cerebellum

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

(Claire), M. V. (2018). Neuromodulation of the Cognitive Cerebellum. (Thesis). Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/104022

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

(Claire), M.C. Verhage. “Neuromodulation of the Cognitive Cerebellum.” 2018. Thesis, Erasmus University Rotterdam. Accessed January 23, 2021. http://hdl.handle.net/1765/104022.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

(Claire), M.C. Verhage. “Neuromodulation of the Cognitive Cerebellum.” 2018. Web. 23 Jan 2021.

Vancouver:

(Claire) MV. Neuromodulation of the Cognitive Cerebellum. [Internet] [Thesis]. Erasmus University Rotterdam; 2018. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1765/104022.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

(Claire) MV. Neuromodulation of the Cognitive Cerebellum. [Thesis]. Erasmus University Rotterdam; 2018. Available from: http://hdl.handle.net/1765/104022

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manitoba

7. Vasquez-Dominguez, Edna Esteli. An investigation of the role of the intraspinal cholinergic system in the modulation of motoneuron voltage threshold.

Degree: Physiology and Pathophysiology, 2016, University of Manitoba

URL: http://hdl.handle.net/1993/31278

► Previous work has demonstrated that rhythmic motor outputs, such as locomotion and scratch induce a hyperpolarization of the voltage threshold (Vth) for action potential initiation… (more)

▼ Previous work has demonstrated that rhythmic motor outputs, such as locomotion and scratch induce a hyperpolarization of the voltage threshold (Vth) for action potential initiation in spinal motoneurons, enhancing their excitability. Descending monoamines were implicated in mediating this effect; however, the recent observation that changes in Vth persist during fictive scratch in cats following acute cervical transection revealed that intraspinal systems, of unknown neuromodulatory identity, also have the ability to regulate motoneuron excitability during motor behaviour. This thesis addresses: 1) whether acetylcholine (ACh) is able to modulate spinal motoneuron Vth, and 2) whether endogenous ACh modulates motoneuron excitability during motor activity without intact descending modulation. Our first study investigates whether ACh from exogenous and/or endogenous sources alters motoneuron Vth. We made intracellular recordings of lumbar motoneurons from neonatal rats to pharmacologically manipulate muscarinic and nicotinic receptor activity. Results show that ACh induces either Vth hyperpolarization, Vth depolarization or no change in Vth depending on the activity state of the network, the ACh concentration, and influences from other systems. Our second study investigates whether intraspinal cholinergic inputs induce Vth hyperpolarization during rhythmic motor output when descending projections are disrupted. For this we developed an in vitro neonatal rat spinal cord preparation to elicit rhythmic activity independently of brainstem or lumbar cord stimulation. Intracellular recordings from motoneurons allowed comparison of the Vth prior to and during rhythmic output, both in the absence and presence of cholinergic antagonists in the lumbar cord. Results show that intraspinal cholinergic mechanisms are active and importantly contribute to modulation of motoneuron Vth during motor output. We suggest that in addition to descending modulation, the spinal cholinergic system regulates motoneuron Vth to either facilitate or inhibit recruitment according to the motor network state. Motoneuron excitability regulation by modification of distinct membrane properties resulting from separate modulatory systems activation during diverse motor behaviours is discussed. This work is the first to demonstrate the role of cholinergic mechanisms in regulating motoneuron excitability through modulation of Vth in an activity based context, and therefore outlines a spinal modulatory system that would contribute to motor control in both normal and pathological states. Advisors/Committee Members: Fedirchuk, Brent (Physiology and Pathophysiology) (supervisor), McCrea, David (Physiology and Pathophysiology).

Subjects/Keywords: Spinal cord; Motoneuron; Neuromodulation; Neurophysiology

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APA (6^th Edition):

Vasquez-Dominguez, E. E. (2016). An investigation of the role of the intraspinal cholinergic system in the modulation of motoneuron voltage threshold. (Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/31278

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vasquez-Dominguez, Edna Esteli. “An investigation of the role of the intraspinal cholinergic system in the modulation of motoneuron voltage threshold.” 2016. Thesis, University of Manitoba. Accessed January 23, 2021. http://hdl.handle.net/1993/31278.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vasquez-Dominguez, Edna Esteli. “An investigation of the role of the intraspinal cholinergic system in the modulation of motoneuron voltage threshold.” 2016. Web. 23 Jan 2021.

Vancouver:

Vasquez-Dominguez EE. An investigation of the role of the intraspinal cholinergic system in the modulation of motoneuron voltage threshold. [Internet] [Thesis]. University of Manitoba; 2016. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1993/31278.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vasquez-Dominguez EE. An investigation of the role of the intraspinal cholinergic system in the modulation of motoneuron voltage threshold. [Thesis]. University of Manitoba; 2016. Available from: http://hdl.handle.net/1993/31278

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Delft University of Technology

8. Saccher, Marta (author). MEMS ultrasound for active implantable devices.

Degree: 2019, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:dcd6bbdb-668c-440c-ba9a-dc315e675a28

►

During the past decade, Implantable biomedical devices have emerged as an efficient treatment for neurological disorders. Among them, low-intensity focused ultrasound (LIFU) has recently gained… (more)

▼

During the past decade, Implantable biomedical devices have emerged as an efficient treatment for neurological disorders. Among them, low-intensity focused ultrasound (LIFU) has recently gained interest due to its focusing ability, depth of penetration and reversible effects. Although the exact biophysical mechanism that leads to the interaction between ultrasound and neurons is not clear yet, many successful applications have been reported both in vitro and in vivo in animals, raising prospects for clinical applications. Nevertheless, treatments were mainly delivered transcranially due to the lack of implantable technologies, constraining the frequency range to below 1 MHz. Thanks to the development of biocompatible capacitive micromachined ultrasound transducers (CMUTs), ultrasound has become implantable, opening the way for high frequency ultrasound neuromodulation. In addition, implantable biomedical devices are becoming smaller and smaller, requiring their power supply to follow this trend. Batteries can be a limiting factor for their miniaturisation and other powering methods have been investigated. Among them, ultrasound as a means to wirelessly transfer power represents the best trade-off between the amount of available power, implanted receiver size, and depth of penetration. Also in this case, biocompatible CMUTs could be used as transducers to power an implanted device. Yet they require a DC bias source in the order of tens of volts which is not practical for an implanted device. In this thesis the application of ultrasound for implantable biomedical devices is investigated. First, the modulation of the excitability of in vitro mice hippocampal brain slices (normal and epileptic) using high frequency sonication protocols is explored. Secondly, wireless power transfer using CMUT devices with charges trapped in the dielectric which do not require a DC bias voltage is investigated. The results indicate that high frequency ultrasound clearly affects the excitability of neurons, having an excitatory effect when delivered using a 5 MHz continuous wave sonication protocol, while it inhibits the neurons when they are exposed to pulsed wave ultrasound at 13 MHz. The intensities used were in line or much lower compared to values used by other groups of researchers. In addition, ultrasound power transfer with an efficiency higher than 48% was achieved using CMUT devices with charges permanently trapped in their Al2O3 layer. This efficiency was in line with values obtained by other groups using piezoelectric transducers. Based on these results, it is clear that ultrasound, specifically using implantable CMUT devices, has a great potential to be used in bioelectronic medicine applications for both the treatment of neurological disorders as well as a means of power transfer.

BioMedical Engineering

Advisors/Committee Members: Dekker, Ronald (mentor), Kawasaki, Shinnosuke (graduation committee), Delft University of Technology (degree granting institution).

Subjects/Keywords: Ultrasound; Neuromodulation; Power transfer; CMUT

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Saccher, M. (. (2019). MEMS ultrasound for active implantable devices. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:dcd6bbdb-668c-440c-ba9a-dc315e675a28

Chicago Manual of Style (16^th Edition):

Saccher, Marta (author). “MEMS ultrasound for active implantable devices.” 2019. Masters Thesis, Delft University of Technology. Accessed January 23, 2021. http://resolver.tudelft.nl/uuid:dcd6bbdb-668c-440c-ba9a-dc315e675a28.

MLA Handbook (7^th Edition):

Saccher, Marta (author). “MEMS ultrasound for active implantable devices.” 2019. Web. 23 Jan 2021.

Vancouver:

Saccher M(. MEMS ultrasound for active implantable devices. [Internet] [Masters thesis]. Delft University of Technology; 2019. [cited 2021 Jan 23]. Available from: http://resolver.tudelft.nl/uuid:dcd6bbdb-668c-440c-ba9a-dc315e675a28.

Council of Science Editors:

Saccher M(. MEMS ultrasound for active implantable devices. [Masters Thesis]. Delft University of Technology; 2019. Available from: http://resolver.tudelft.nl/uuid:dcd6bbdb-668c-440c-ba9a-dc315e675a28

University of Minnesota

9. Newhoff, Morgan. An Investigation of the Cellular Mechanisms Underlying Ultrasound Neuromodulation.

Degree: PhD, Neuroscience, 2020, University of Minnesota

URL: http://hdl.handle.net/11299/216851

► Focused ultrasound is an emerging neuromodulation technology with the unique potential to noninvasively modulate neuronal activity in deep brain structures with high spatial specificity, offering… (more)

▼ Focused ultrasound is an emerging neuromodulation technology with the unique potential to noninvasively modulate neuronal activity in deep brain structures with high spatial specificity, offering a potential alternative to invasive neural stimulators. Decades of research have confirmed that ultrasound induces profound effects on neuronal firing rates in a wide range of animal systems, yet the direction (increase or decrease) and primary effector of these effects remain a subject of debate. Here, we describe experiments designed to assess these core questions in a tractable invertebrate model, the medicinal leech (Hirudo verbana). We examined the effects of ultrasound (960 kHz) on an identified motoneuron, a class of cells believed to lack canonical mechanosensitive ion channels, and whose response to ultrasound we predict to be reflective of effects on most neuronal cell types. We observed both neuronal excitation and inhibition, with a bias towards inhibitory effects. These effects were direct, and persisted in the presence of synaptic blockers. Importantly, these effects were only observed when applying ultrasound of sufficient duration to generate heating in excess of 2 °C. Similar durations of ultrasound in a low-heat paradigm were insufficient to induce changes in neuronal firing rate. We thus concluded that heat is the primary effector of ultrasound neuromodulation in this system, which was reinforced by our ability to elicit comparable effects through the targeted application of heat alone. Additional experiments using non-thermal short pulses of ultrasound on sensory neurons failed to produce neuronal activation at and above intensities at which others have reported excitation, with the exception of effects we deemed artifactual due to electrode resonance, and which could be reliably mimicked with micromovements of the recording electrode. We conclude that the mechanical effects of ultrasound, which are frequently described in the literature, are less reliably achieved than thermal effects, and observations ascribed to mechanical effects may be confounded by activation of synaptically-coupled sensory structures or artifact associated with electrode resonance. Nonetheless, ultrasound can generate significant modulation at temperatures < 5 °C, which are believed to be safe for moderate durations. Ultrasound should therefore be investigated as a thermal neuromodulation technology for clinical use.

Subjects/Keywords: Electrophysiology; Leech; Neuromodulation; Ultrasound

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APA (6^th Edition):

Newhoff, M. (2020). An Investigation of the Cellular Mechanisms Underlying Ultrasound Neuromodulation. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/216851

Chicago Manual of Style (16^th Edition):

Newhoff, Morgan. “An Investigation of the Cellular Mechanisms Underlying Ultrasound Neuromodulation.” 2020. Doctoral Dissertation, University of Minnesota. Accessed January 23, 2021. http://hdl.handle.net/11299/216851.

MLA Handbook (7^th Edition):

Newhoff, Morgan. “An Investigation of the Cellular Mechanisms Underlying Ultrasound Neuromodulation.” 2020. Web. 23 Jan 2021.

Vancouver:

Newhoff M. An Investigation of the Cellular Mechanisms Underlying Ultrasound Neuromodulation. [Internet] [Doctoral dissertation]. University of Minnesota; 2020. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/11299/216851.

Council of Science Editors:

Newhoff M. An Investigation of the Cellular Mechanisms Underlying Ultrasound Neuromodulation. [Doctoral Dissertation]. University of Minnesota; 2020. Available from: http://hdl.handle.net/11299/216851

Queens University

10. Gagolewicz, Peter. Preferential Potentiation of Weaker Inputs to Primary Visual Cortex by Activation of the Basal Forebrain in Urethane Anesthetized Rats .

Degree: Neuroscience Studies, 2009, Queens University

URL: http://hdl.handle.net/1974/1730

► The ability of the brain to store information and adapt to changes in the sensory environment stems from the capability of neurons to change their… (more)

▼ The ability of the brain to store information and adapt to changes in the sensory environment stems from the capability of neurons to change their communication with other neurons (“synaptic plasticity”). However, the ability of synapses to change (e.g., strengthen) is profoundly influenced by various chemical signals released in the nervous system (neuromodulators). Such modulatory effects may be preferential for different types of synapses. For example, cortical acetylcholine (ACh) has been shown to result in a relative enhancement of thalamocortical over intracortical synapses. Here, I tested the hypothesis that field postsynaptic potentials (fPSPs) in the rat primary visual cortex (V1) evoked by single pulse stimulation of the lateral geniculate nucleus (LGN) can be potentiated when LGN stimulation is paired with short bursts of stimuli applied to the basal forebrain (BF), the major source of ACh released in the cortex. Stimulation of the ipsi- and contralateral LGN elicited fPSPs in V1, with fPSPs triggered from the contralateral LGN exhibiting longer latencies and smaller amplitudes relative to fPSPs in ipsilateral projections. Stimulation bursts applied to the BF, paired with single, delayed LGN pulses, resulted in an enhancement of fPSP amplitude (~25%) for contralateral inputs at short (130 ms), but not longer (200-1000 ms) pairing intervals, while ipsilateral fPSPs failed to show significant potentiation over these intervals. The enhancement of the contralateral LGN-V1 fiber system induced by BF pairings was abolished by systemic or V1 application of the muscarinic receptor antagonist scopolamine, while systemic nicotinic receptor blockade was ineffective. These data suggest that there is a differential capacity for plasticity induction between strong, ipsilateral and weaker, contralateral fiber inputs to V1, with weaker inputs exhibiting greater synaptic enhancement following pairing with BF stimulation to elicit cortical ACh release. This preferential readiness for synaptic potentiation in normally weaker, non-dominant fiber inputs to V1 may facilitate the detection and integration of separate sensory signals originating in thalamic sensory nuclei.

Subjects/Keywords: Acetylcholine ; Neuromodulation

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APA (6^th Edition):

Gagolewicz, P. (2009). Preferential Potentiation of Weaker Inputs to Primary Visual Cortex by Activation of the Basal Forebrain in Urethane Anesthetized Rats . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/1730

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gagolewicz, Peter. “Preferential Potentiation of Weaker Inputs to Primary Visual Cortex by Activation of the Basal Forebrain in Urethane Anesthetized Rats .” 2009. Thesis, Queens University. Accessed January 23, 2021. http://hdl.handle.net/1974/1730.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gagolewicz, Peter. “Preferential Potentiation of Weaker Inputs to Primary Visual Cortex by Activation of the Basal Forebrain in Urethane Anesthetized Rats .” 2009. Web. 23 Jan 2021.

Vancouver:

Gagolewicz P. Preferential Potentiation of Weaker Inputs to Primary Visual Cortex by Activation of the Basal Forebrain in Urethane Anesthetized Rats . [Internet] [Thesis]. Queens University; 2009. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1974/1730.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gagolewicz P. Preferential Potentiation of Weaker Inputs to Primary Visual Cortex by Activation of the Basal Forebrain in Urethane Anesthetized Rats . [Thesis]. Queens University; 2009. Available from: http://hdl.handle.net/1974/1730

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Georgia State University

11. Barnett, William. Mechanisms of the Coregulation of Multiple Ionic Currents for the Control of Neuronal Activity.

Degree: PhD, Neuroscience Institute, 2015, Georgia State University

URL: https://scholarworks.gsu.edu/neurosci_diss/18

► An open question in contemporary neuroscience is how neuromodulators coregulate multiple conductances to maintain functional neuronal activity. Neuromodulators enact changes to properties of biophysical… (more)

Subjects/Keywords: Bursting; Central pattern generator; Neuromodulation

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APA (6^th Edition):

Barnett, W. (2015). Mechanisms of the Coregulation of Multiple Ionic Currents for the Control of Neuronal Activity. (Doctoral Dissertation). Georgia State University. Retrieved from https://scholarworks.gsu.edu/neurosci_diss/18

Chicago Manual of Style (16^th Edition):

Barnett, William. “Mechanisms of the Coregulation of Multiple Ionic Currents for the Control of Neuronal Activity.” 2015. Doctoral Dissertation, Georgia State University. Accessed January 23, 2021. https://scholarworks.gsu.edu/neurosci_diss/18.

MLA Handbook (7^th Edition):

Barnett, William. “Mechanisms of the Coregulation of Multiple Ionic Currents for the Control of Neuronal Activity.” 2015. Web. 23 Jan 2021.

Vancouver:

Barnett W. Mechanisms of the Coregulation of Multiple Ionic Currents for the Control of Neuronal Activity. [Internet] [Doctoral dissertation]. Georgia State University; 2015. [cited 2021 Jan 23]. Available from: https://scholarworks.gsu.edu/neurosci_diss/18.

Council of Science Editors:

Barnett W. Mechanisms of the Coregulation of Multiple Ionic Currents for the Control of Neuronal Activity. [Doctoral Dissertation]. Georgia State University; 2015. Available from: https://scholarworks.gsu.edu/neurosci_diss/18

12. Tassi, Luiz Eduardo. O desempenho de ratos em jogo estratégico e os efeitos da modulação dopaminérgica.

Degree: PhD, Fisiologia Geral, 2011, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/41/41135/tde-21092011-084317/ ;

►

A interação entre agentes inteligentes na disputa por recursos necessários à sobrevivência é um fato onipresente na luta pela vida. Este tipo de interação é… (more)

▼

A interação entre agentes inteligentes na disputa por recursos necessários à sobrevivência é um fato onipresente na luta pela vida. Este tipo de interação é estudado e formalizado matematicamente pela teoria dos jogos. Na literatura experimental encontramos vários estudos envolvendo primatas humanos e não humanos em tarefas de jogos estratégicos, mas, até o momento, não foi desenvolvido nenhum modelo deste comportamento com roedores. Estudos do comportamento animal mostram que estes aprendem e aprimoram este tipo de estratégias através de aprendizagem por reforço. O elemento central dos modelos computacionais de aprendizado por reforço é o sinal de violação de expectativa, que sinaliza o quanto um resultado difere, para mais ou para menos, do esperado. Este sinal é utilizado pelo agente para atualização dos valores e, assim, da probabilidade de escolha das opções. A pesquisa neurofisiológica tem consistentemente demonstrado que o sinal fásico emitido pelo sistema dopaminérgico conforma-se muito de perto às características do sinal descrito pela teoria computacional. Dessa maneira, os objetivos do presente estudo são pesquisar (1) se roedores são capazes de jogar um jogo estratégico simples e se a evolução do seu desempenho é consistente com o aprendizado por reforço e (2) se os efeitos de agonistas e antagonistas dopaminérgicos na estratégia de jogo são consistentes com a teoria segundo a qual o sinal dopaminérgico fásico desempenha função central na atualização constante da estratégia de jogo. Nossos resultados demonstram que, neste jogo estratégico, roedores efetivamente são capazes de um desempenho muito próximo do normativo, que seu desempenho é consistente com o aprendizado por reforço e, finalmente, que o sistema dopaminérgico está envolvido no processo de atualização da estratégia.

Intelligent agents competing for the resources necessary for survival is a universal factor in the struggle for life. This type of interaction has been studied and mathematically formalized by game theory. In scientific literature we have come across several studies involving human and non-human primates carrying out strategic game tasks; however, until now, no model for such behavior has been developed for rodents. Animal behavior studies have shown that animals learn and develop strategies through reinforcement learning. A central element of computational models of reinforcement learning is the reward-prediction error signal, which indicates how much a result differs, either positively or negatively, from the expected result. This signal is used by the agent to update the values of its options, and so their probability of being chosen. Neurophysiologic research has consistently shown that the phasic signal emitted by the dopamine system conforms very closely to the characteristics of the signal described by computational theory. The purposes of this study are: (1) to discover whether rodents are capable of playing a simple strategic game and whether the evolution of their performance is consistent with reinforcement learning;…

Advisors/Committee Members: Xavier, Gilberto Fernando.

Subjects/Keywords: Decision making; Neuromodulação; Neuromodulation; Tomada de decisão

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APA (6^th Edition):

Tassi, L. E. (2011). O desempenho de ratos em jogo estratégico e os efeitos da modulação dopaminérgica. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/41/41135/tde-21092011-084317/ ;

Chicago Manual of Style (16^th Edition):

Tassi, Luiz Eduardo. “O desempenho de ratos em jogo estratégico e os efeitos da modulação dopaminérgica.” 2011. Doctoral Dissertation, University of São Paulo. Accessed January 23, 2021. http://www.teses.usp.br/teses/disponiveis/41/41135/tde-21092011-084317/ ;.

MLA Handbook (7^th Edition):

Tassi, Luiz Eduardo. “O desempenho de ratos em jogo estratégico e os efeitos da modulação dopaminérgica.” 2011. Web. 23 Jan 2021.

Vancouver:

Tassi LE. O desempenho de ratos em jogo estratégico e os efeitos da modulação dopaminérgica. [Internet] [Doctoral dissertation]. University of São Paulo; 2011. [cited 2021 Jan 23]. Available from: http://www.teses.usp.br/teses/disponiveis/41/41135/tde-21092011-084317/ ;.

Council of Science Editors:

Tassi LE. O desempenho de ratos em jogo estratégico e os efeitos da modulação dopaminérgica. [Doctoral Dissertation]. University of São Paulo; 2011. Available from: http://www.teses.usp.br/teses/disponiveis/41/41135/tde-21092011-084317/ ;

Vanderbilt University

13. Duke, Austin Robert. Selective control of electrical neural activation using infrared light.

Degree: PhD, Biomedical Engineering, 2012, Vanderbilt University

URL: http://hdl.handle.net/1803/14812

► The neurostimulation market is one of the fastest growing sectors of the medical device industry. This is primarily due to both an increasing patient population… (more)

▼ The neurostimulation market is one of the fastest growing sectors of the medical device industry. This is primarily due to both an increasing patient population and recent advances in clinical neural interfaces. However, the need for restored neural function remains largely unmet and will require refinements to current technology and development of novel solutions. To fully control neural function and analyze the dynamics of neural circuitry, it is necessary to have tools capable of selectively exciting and inhibiting sub-populations of neurons. Advances in electrical neural interfaces have greatly improved selective stimulation. In addition, electrical methods of blocking nerve conduction have been demonstrated. Recently, a novel optical stimulation technique was developed whereby pulsed infrared light achieves neural activation with spatiotemporal precision. This dissertation investigates the hypothesis that electrical and optical techniques are complimentary and can be cooperatively applied to control neural function. The synergistic combination of pulsed electric current and infrared light is evaluated in a myelinated mammalian nerve, and the methodology is refined through systematic investigation in both unmyelinated and myelinated nerve preparations. This hybrid approach to neurostimulation exhibits spatial specificity of activation while reducing stimulation currents and optical radiant exposures. Infrared light is not only shown to selectively enhance electrical neural excitation, but also to inhibit electrically initiated axonal activation and block propagating action potentials. The utility of this technique is demonstrated through the modulation of neuromuscular function, with the underlying mechanism likely mediated by local infrared-induced changes in baseline nerve temperature. Application of infrared light is shown to selectively enhance and inhibit electrically stimulated muscle activity and contraction force in both unmyelinated and myelinated nerves. The results of this work indicate there is a rich set of interactions between light and excitable tissues, and infrared light can be applied as a multi-faceted tool for selectively controlling neural function for both research and clinical applications. Advisors/Committee Members: Anita Mahadevan-Jansen (committee member), Peter Konrad (committee member), Hillel Chiel (committee member), Bob Galloway (committee member), Claus-Peter Richter (committee member), E. Duco Jansen (Committee Chair).

Subjects/Keywords: temperature; hybrid; neuromodulation; neurostimulation; nerve stimulation; infrared

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APA (6^th Edition):

Duke, A. R. (2012). Selective control of electrical neural activation using infrared light. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/14812

Chicago Manual of Style (16^th Edition):

Duke, Austin Robert. “Selective control of electrical neural activation using infrared light.” 2012. Doctoral Dissertation, Vanderbilt University. Accessed January 23, 2021. http://hdl.handle.net/1803/14812.

MLA Handbook (7^th Edition):

Duke, Austin Robert. “Selective control of electrical neural activation using infrared light.” 2012. Web. 23 Jan 2021.

Vancouver:

Duke AR. Selective control of electrical neural activation using infrared light. [Internet] [Doctoral dissertation]. Vanderbilt University; 2012. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1803/14812.

Council of Science Editors:

Duke AR. Selective control of electrical neural activation using infrared light. [Doctoral Dissertation]. Vanderbilt University; 2012. Available from: http://hdl.handle.net/1803/14812

Vanderbilt University

14. Chaplin, Vandiver Lazenby. Precision and Selectivity: New Techniques in Image Guided Focused Ultrasound.

Degree: PhD, Chemical and Physical Biology, 2018, Vanderbilt University

URL: http://hdl.handle.net/1803/11013

► Focused ultrasound (FUS) is a non-invasive technology with a growing body of applications in interventional therapy and preclinical research. FUS uses geometrically focused transducers that… (more)

Subjects/Keywords: focused ultrasound; magnetic resonance; HIFU; neuromodulation

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APA (6^th Edition):

Chaplin, V. L. (2018). Precision and Selectivity: New Techniques in Image Guided Focused Ultrasound. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/11013

Chicago Manual of Style (16^th Edition):

Chaplin, Vandiver Lazenby. “Precision and Selectivity: New Techniques in Image Guided Focused Ultrasound.” 2018. Doctoral Dissertation, Vanderbilt University. Accessed January 23, 2021. http://hdl.handle.net/1803/11013.

MLA Handbook (7^th Edition):

Chaplin, Vandiver Lazenby. “Precision and Selectivity: New Techniques in Image Guided Focused Ultrasound.” 2018. Web. 23 Jan 2021.

Vancouver:

Chaplin VL. Precision and Selectivity: New Techniques in Image Guided Focused Ultrasound. [Internet] [Doctoral dissertation]. Vanderbilt University; 2018. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1803/11013.

Council of Science Editors:

Chaplin VL. Precision and Selectivity: New Techniques in Image Guided Focused Ultrasound. [Doctoral Dissertation]. Vanderbilt University; 2018. Available from: http://hdl.handle.net/1803/11013

Penn State University

15. Sadeghi Gougheri, Hesam. high-performance integrated circuits for ultrasound neuromodulation and power management of medical implants.

Degree: 2020, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/17537hqs5287

► In general, this Ph.D. thesis aims at developing innovative technologies for interfacing with the central and peripheral nervous systems. More particularly, this thesis is focused… (more)

▼ In general, this Ph.D. thesis aims at developing innovative technologies for interfacing with the central and peripheral nervous systems. More particularly, this thesis is focused on the design, development, and testing of novel circuits and systems for ultrasound neuromodulation and power management of those implantable medical devices (IMDs) which are powered by wireless power transmission (WPT) via inductive coupling. First, a new class of integrated power management (IPM) application-specific integrated circuits (ASICs) is proposed for efficient, robust, and long-range inductive power transmission. Unlike conventional IPM ASICs with voltage-mode (VM) operation, a current-mode (CM) IPM structure is proposed in which the receiver coil is employed as a current source. Several features have been added to the CM IPM structure to noticeably improve performance of the wireless IMDs in terms of voltage regulation, maximum provided output power, and lifetime. In the second part, the concept of microscopic ultrasound stimulation (μUS) is proposed in which either an electronically phased array of ultrasound transducers or several millimeter-sized focused transducers can directly be placed on the brain surface with partially removed skull (or over thinned skull) to deliver a focused ultrasound pressure to the neural target. A comprehensive study of ultrasound transducer characterization is presented to find optimal design of the transducers for μUS application. An ultrasound neuromodulation ASIC is designed and fabricated to drive the transducer with sufficient power, and finally a couple of preliminary animal experiments with commercial off-the-shelf (COTS) components are carried out. In chapter 1 of this dissertation, the proposed technologies for ultrasound neuromodulation and power management of IMDs are briefly introduced, and an overview over current technologies for neuromodulation and WPT to IMDs is presented. Also, the main contributions of this thesis are briefly described. In chapter 2, a current-based resonant power delivery (CRPD) technique is presented for extended-range WPT. In chapter 3, a self-regulated reconfigurable voltage/current-mode integrated power management (VCIPM) is presented for robust inductive WPT. In chapter 4, optimal wireless receiver structure for omnidirectional WPT is discussed. A self-regulated seamless-voltage/current-mode IPM with energy recycling capability is presented in chapter 5. To improve maximum output power provided to IMDs, a dual-output reconfigurable shared-inductor boost-converter/current-mode IPM is presented in chapter 6. In chapter 7, a comprehensive study of ultrasound transducer characteristics in μUS is presented. An ASIC for ultrasound neuromodulation is proposed in chapter 8. Finally, in chapter 9 preliminary animal experiments and future works are discussed. This research has resulted so far in 6 journal papers, 8 peer-reviewed conference papers, 1 pending US patent, and 1 book chapter. Advisors/Committee Members: Mehdi Kiani, Dissertation Advisor/Co-Advisor, Mehdi Kiani, Committee Chair/Co-Chair, Ram Mohan Narayanan, Committee Member, Seyedehaida Ebrahimi, Committee Member, Bruce Gluckman, Outside Member, Kultegin Aydin, Program Head/Chair.

Subjects/Keywords: ultrasound neuromodulation; inductive power transmission; power management

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APA (6^th Edition):

Sadeghi Gougheri, H. (2020). high-performance integrated circuits for ultrasound neuromodulation and power management of medical implants. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/17537hqs5287

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sadeghi Gougheri, Hesam. “high-performance integrated circuits for ultrasound neuromodulation and power management of medical implants.” 2020. Thesis, Penn State University. Accessed January 23, 2021. https://submit-etda.libraries.psu.edu/catalog/17537hqs5287.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sadeghi Gougheri, Hesam. “high-performance integrated circuits for ultrasound neuromodulation and power management of medical implants.” 2020. Web. 23 Jan 2021.

Vancouver:

Sadeghi Gougheri H. high-performance integrated circuits for ultrasound neuromodulation and power management of medical implants. [Internet] [Thesis]. Penn State University; 2020. [cited 2021 Jan 23]. Available from: https://submit-etda.libraries.psu.edu/catalog/17537hqs5287.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sadeghi Gougheri H. high-performance integrated circuits for ultrasound neuromodulation and power management of medical implants. [Thesis]. Penn State University; 2020. Available from: https://submit-etda.libraries.psu.edu/catalog/17537hqs5287

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Connecticut

16. Ellenberg, Justin T. Proportional Suppression of NMDA and AMPA Mediated Synaptic Responses in Layer 2/3 Pyramids from Rat Visual Cortex by Adenosine.

Degree: MS, Psychological Sciences, 2017, University of Connecticut

URL: https://opencommons.uconn.edu/gs_theses/1090

► Adenosine (ADO) is an abundant endogenous neuromodulator, with a generally suppressive effect on excitatory synaptic transmission. Previous research has shown that in different brain… (more)

Subjects/Keywords: adenosine; NMDA; AMPA; synaptic transmission; neocortex; neuromodulation

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APA (6^th Edition):

Ellenberg, J. T. (2017). Proportional Suppression of NMDA and AMPA Mediated Synaptic Responses in Layer 2/3 Pyramids from Rat Visual Cortex by Adenosine. (Masters Thesis). University of Connecticut. Retrieved from https://opencommons.uconn.edu/gs_theses/1090

Chicago Manual of Style (16^th Edition):

Ellenberg, Justin T. “Proportional Suppression of NMDA and AMPA Mediated Synaptic Responses in Layer 2/3 Pyramids from Rat Visual Cortex by Adenosine.” 2017. Masters Thesis, University of Connecticut. Accessed January 23, 2021. https://opencommons.uconn.edu/gs_theses/1090.

MLA Handbook (7^th Edition):

Ellenberg, Justin T. “Proportional Suppression of NMDA and AMPA Mediated Synaptic Responses in Layer 2/3 Pyramids from Rat Visual Cortex by Adenosine.” 2017. Web. 23 Jan 2021.

Vancouver:

Ellenberg JT. Proportional Suppression of NMDA and AMPA Mediated Synaptic Responses in Layer 2/3 Pyramids from Rat Visual Cortex by Adenosine. [Internet] [Masters thesis]. University of Connecticut; 2017. [cited 2021 Jan 23]. Available from: https://opencommons.uconn.edu/gs_theses/1090.

Council of Science Editors:

Ellenberg JT. Proportional Suppression of NMDA and AMPA Mediated Synaptic Responses in Layer 2/3 Pyramids from Rat Visual Cortex by Adenosine. [Masters Thesis]. University of Connecticut; 2017. Available from: https://opencommons.uconn.edu/gs_theses/1090

Queen Mary, University of London

17. Thin, Noel N. K. S. The clinical effects of neuromodulation therapies in the treatment of faecal incontinence.

Degree: Thesis (M.D.), 2016, Queen Mary, University of London

URL: http://qmro.qmul.ac.uk/xmlui/handle/123456789/24248 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.765835

► Background and Aims Sacral nerve stimulation (SNS) is an established therapy for faecal incontinence (FI). Percutaneous tibial nerve stimulation (PTNS) is a newer, less-invasive treatment.… (more)

▼ Background and Aims Sacral nerve stimulation (SNS) is an established therapy for faecal incontinence (FI). Percutaneous tibial nerve stimulation (PTNS) is a newer, less-invasive treatment. The effectiveness, cost and acceptability of these treatments have not been systematically compared. Methods A systematic review of neuromodulation interventions for FI and an investigator-blinded, randomised pilot trial of PTNS vs. SNS including parallel quantitative (clinical outcomes and cost) and qualitative studies. Results The systematic review determined on intention-to-treat, the median success rates for SNS were 63% (range 33-66%), 58% (range 52-81%) and 54% (range 50-58%) in the short, medium and long terms respectively. The success rate for PTNS was 59% at 12 months. In the pilot trial: 40 patients (39 female; mean age 59 years) met eligibility criteria. As designed, 23 were randomised to receive SNS and 17 PTNS. 15 patients progressed to permanent SNS implantation and 16 patients received a full course of PTNS. Within group effect sizes were marginally greater for SNS than PTNS on available case analysis. FI episodes per week at baseline, 3 months and 6 months follow-up: SNS median 5.75 (IQR 5.75-15.5 ) [mean 11.4 (SD 12.0)], 2.5 (2-4.5) [4.0 (4.0)], 1.75 (1.5-5) [4.9 (6.9)], vs. PTNS median 6.5 (IQR 2.5- 16.5) [mean 10.6 (SD 11.2)], 3.5 (0.75-7.25) [5.8 (6.9)], 2.5 (0.75-10.75) [6.3 (6.9)]. At least 50% improvement in FI episodes per week at 6 months: SNS 61% vs. PTNS 47%. Effect estimates for SNS with chronic implanted stimulation were larger (67% at 6 months). Clinical FI scores and quality of life improvements complemented these results. Qualitative analysis demonstrated a very high acceptability and safety profile for both treatments. Total costs were £2,906 (SD £122) per patient for PTNS and £12,748 (SD £4,175) for SNS. Conclusions Definitive trial data between SNS or PTNS is lacking. This RCT pilot study determined that in the short-term, SNS confers a small clinical benefit over PTNS for FI but is much more expensive.

Subjects/Keywords: Bowel Research; Neuromodulation therapies; Faecal incontinence

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APA (6^th Edition):

Thin, N. N. K. S. (2016). The clinical effects of neuromodulation therapies in the treatment of faecal incontinence. (Doctoral Dissertation). Queen Mary, University of London. Retrieved from http://qmro.qmul.ac.uk/xmlui/handle/123456789/24248 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.765835

Chicago Manual of Style (16^th Edition):

Thin, Noel N K S. “The clinical effects of neuromodulation therapies in the treatment of faecal incontinence.” 2016. Doctoral Dissertation, Queen Mary, University of London. Accessed January 23, 2021. http://qmro.qmul.ac.uk/xmlui/handle/123456789/24248 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.765835.

MLA Handbook (7^th Edition):

Thin, Noel N K S. “The clinical effects of neuromodulation therapies in the treatment of faecal incontinence.” 2016. Web. 23 Jan 2021.

Vancouver:

Thin NNKS. The clinical effects of neuromodulation therapies in the treatment of faecal incontinence. [Internet] [Doctoral dissertation]. Queen Mary, University of London; 2016. [cited 2021 Jan 23]. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/24248 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.765835.

Council of Science Editors:

Thin NNKS. The clinical effects of neuromodulation therapies in the treatment of faecal incontinence. [Doctoral Dissertation]. Queen Mary, University of London; 2016. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/24248 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.765835

Erasmus University Rotterdam

18. Vliet, Rick. Non-invasive Neuromodulation in Motor Rehabilitation after Stroke.

Degree: 2020, Erasmus University Rotterdam

URL: http://hdl.handle.net/1765/125516

In this thesis, we aimed to integrate recent insights on motor learning, stroke recovery and neuromodulation with the ultimate goal to improve upper limb rehabilitation after stroke.

Subjects/Keywords: Neuromodulation; stroke; rehabilitation

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APA (6^th Edition):

Vliet, R. (2020). Non-invasive Neuromodulation in Motor Rehabilitation after Stroke. (Doctoral Dissertation). Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/125516

Chicago Manual of Style (16^th Edition):

Vliet, Rick. “Non-invasive Neuromodulation in Motor Rehabilitation after Stroke.” 2020. Doctoral Dissertation, Erasmus University Rotterdam. Accessed January 23, 2021. http://hdl.handle.net/1765/125516.

MLA Handbook (7^th Edition):

Vliet, Rick. “Non-invasive Neuromodulation in Motor Rehabilitation after Stroke.” 2020. Web. 23 Jan 2021.

Vancouver:

Vliet R. Non-invasive Neuromodulation in Motor Rehabilitation after Stroke. [Internet] [Doctoral dissertation]. Erasmus University Rotterdam; 2020. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1765/125516.

Council of Science Editors:

Vliet R. Non-invasive Neuromodulation in Motor Rehabilitation after Stroke. [Doctoral Dissertation]. Erasmus University Rotterdam; 2020. Available from: http://hdl.handle.net/1765/125516

University of Minnesota

19. Nagaraj, Vivek. Optimizing electrical brain stimulation for seizure disorders.

Degree: PhD, Neuroscience, 2017, University of Minnesota

URL: http://hdl.handle.net/11299/188920

► Approximately 1% of the world population is afflicted with Epilepsy. For many patients, antiepileptic drugs do not fully control seizures. Electrical brain stimulation therapies have… (more)

Subjects/Keywords: Closed-loop; Epilepsy; Neuromodulation; Optimization; Seizure

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APA (6^th Edition):

Nagaraj, V. (2017). Optimizing electrical brain stimulation for seizure disorders. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/188920

Chicago Manual of Style (16^th Edition):

Nagaraj, Vivek. “Optimizing electrical brain stimulation for seizure disorders.” 2017. Doctoral Dissertation, University of Minnesota. Accessed January 23, 2021. http://hdl.handle.net/11299/188920.

MLA Handbook (7^th Edition):

Nagaraj, Vivek. “Optimizing electrical brain stimulation for seizure disorders.” 2017. Web. 23 Jan 2021.

Vancouver:

Nagaraj V. Optimizing electrical brain stimulation for seizure disorders. [Internet] [Doctoral dissertation]. University of Minnesota; 2017. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/11299/188920.

Council of Science Editors:

Nagaraj V. Optimizing electrical brain stimulation for seizure disorders. [Doctoral Dissertation]. University of Minnesota; 2017. Available from: http://hdl.handle.net/11299/188920

University of Minnesota

20. Roy, Abhrajeet. Delineating the Neural Correlates of Visual Awareness through the Integration of Multimodal Neuroimaging and Noninvasive Electrical Neuromodulation.

Degree: PhD, Biomedical Engineering, 2016, University of Minnesota

URL: http://hdl.handle.net/11299/202147

► In recent years, there has been a push to develop a fundamental theory of consciousness in the neuroscience community. However, to date, the physical mechanisms… (more)

Subjects/Keywords: awareness; consciousness; EEG-fMRI; neuromodulation; rivalry; vision

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APA (6^th Edition):

Roy, A. (2016). Delineating the Neural Correlates of Visual Awareness through the Integration of Multimodal Neuroimaging and Noninvasive Electrical Neuromodulation. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/202147

Chicago Manual of Style (16^th Edition):

Roy, Abhrajeet. “Delineating the Neural Correlates of Visual Awareness through the Integration of Multimodal Neuroimaging and Noninvasive Electrical Neuromodulation.” 2016. Doctoral Dissertation, University of Minnesota. Accessed January 23, 2021. http://hdl.handle.net/11299/202147.

MLA Handbook (7^th Edition):

Roy, Abhrajeet. “Delineating the Neural Correlates of Visual Awareness through the Integration of Multimodal Neuroimaging and Noninvasive Electrical Neuromodulation.” 2016. Web. 23 Jan 2021.

Vancouver:

Roy A. Delineating the Neural Correlates of Visual Awareness through the Integration of Multimodal Neuroimaging and Noninvasive Electrical Neuromodulation. [Internet] [Doctoral dissertation]. University of Minnesota; 2016. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/11299/202147.

Council of Science Editors:

Roy A. Delineating the Neural Correlates of Visual Awareness through the Integration of Multimodal Neuroimaging and Noninvasive Electrical Neuromodulation. [Doctoral Dissertation]. University of Minnesota; 2016. Available from: http://hdl.handle.net/11299/202147

University of Minnesota

21. Gloeckner, Cory Dale. Inducing Neural Plasticity and Modulation Using Multisensory Stimulation: Techniques for Sensory Disorder Treatment.

Degree: PhD, Biomedical Engineering, 2017, University of Minnesota

URL: http://hdl.handle.net/11299/206274

► In this dissertation, we characterized the modulatory and plasticity effects of paired multisensory stimulation on neural firing in sensory systems across the brain. In the… (more)

▼ In this dissertation, we characterized the modulatory and plasticity effects of paired multisensory stimulation on neural firing in sensory systems across the brain. In the auditory system, we discovered that electrical somatosensory stimulation can either suppress or facilitate neural firing in the inferior colliculus (IC) and primary auditory cortex (A1) depending stimulation location. We also tested plasticity effects in A1 in response to paired somatosensory and acoustic stimulation with different inter-stimulus delays in anesthetized guinea pigs, and found that plasticity induced by paired acoustic and right mastoid stimulation was consistently suppressive regardless of delay, but paired acoustic and pinna stimulation was timing-dependent, where one inter-stimulus delay was consistently suppressive while other delays induced random changes. These experiments were repeated in awake animals with paired acoustic and pinna stimulation, and two animal groups of different stress levels were used to assess stress effects on plasticity. We found that in low-stress animals, the same inter-stimulus delay was consistently suppressive and a neighboring delay was consistently facilitative across all animals, which matches previous invasive spike-timing dependent plasticity studies (anesthesia may have affected these trends). Meanwhile, high-stress animal results were not consistent with expected time dependence and exhibited no trends across inter-stimulus delays, indicating that stress can have adverse effects on neuromodulation plasticity outcomes. In all other primary sensory cortices, we found that differential effects can be induced with paired sensory stimulation such that the location, amount, type, and timing of plasticity can be controlled by strategically choosing sensory stimulation parameters for modulation of each sensory cortex. We also investigated the ability to target subpopulations of neurons within a brain region and found that by stimulating at levels near activation thresholds, specific subpopulations of IC neurons can be targeted by varying somatosensory stimulation location. Furthermore, acoustic stimulation can excite or modulate specific areas of somatosensory cortex, and we mapped the guinea pig homunculus to characterize this. Overall, these findings illustrate the immense interconnectivity between sensory systems, and multisensory stimulation may provide a noninvasive neuromodulation approach for inducing controlled plasticity to disrupt pathogenic neural activity in neural sensory disorders, such as tinnitus and pain.

Subjects/Keywords: cortex; multisensory; neuromodulation; pain; plasticity; tinnitus

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APA (6^th Edition):

Gloeckner, C. D. (2017). Inducing Neural Plasticity and Modulation Using Multisensory Stimulation: Techniques for Sensory Disorder Treatment. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/206274

Chicago Manual of Style (16^th Edition):

Gloeckner, Cory Dale. “Inducing Neural Plasticity and Modulation Using Multisensory Stimulation: Techniques for Sensory Disorder Treatment.” 2017. Doctoral Dissertation, University of Minnesota. Accessed January 23, 2021. http://hdl.handle.net/11299/206274.

MLA Handbook (7^th Edition):

Gloeckner, Cory Dale. “Inducing Neural Plasticity and Modulation Using Multisensory Stimulation: Techniques for Sensory Disorder Treatment.” 2017. Web. 23 Jan 2021.

Vancouver:

Gloeckner CD. Inducing Neural Plasticity and Modulation Using Multisensory Stimulation: Techniques for Sensory Disorder Treatment. [Internet] [Doctoral dissertation]. University of Minnesota; 2017. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/11299/206274.

Council of Science Editors:

Gloeckner CD. Inducing Neural Plasticity and Modulation Using Multisensory Stimulation: Techniques for Sensory Disorder Treatment. [Doctoral Dissertation]. University of Minnesota; 2017. Available from: http://hdl.handle.net/11299/206274

University of Minnesota

22. Offutt, Sarah. The Inferior Colliculus: A Target for Deep Brain Stimulation for Tinnitus Suppression.

Degree: PhD, Biomedical Engineering, 2015, University of Minnesota

URL: http://hdl.handle.net/11299/209122

► Tinnitus is a neurological condition that manifests as a phantom auditory perception in the absence of an external sound source. Tinnitus is often caused by… (more)

▼ Tinnitus is a neurological condition that manifests as a phantom auditory perception in the absence of an external sound source. Tinnitus is often caused by hearing loss associated with noise exposure or aging and as such, the prevalence is only expected to rise in the coming years. Currently there is no cure for tinnitus and available treatment options have only shown limited success, thus there is an ever present need for continued research into new treatments. In this thesis we propose a new approach to treating tinnitus that uses deep brain stimulation to target the inferior colliculus (IC) with the goal of altering tinnitus-related neural activity, such as hyperactivity and increased neural synchrony, to suppress the tinnitus percept. We hypothesize that stimulation of the outer cortices of the inferior colliculus will modulate the tinnitus-affected neurons in the central region of the inferior colliculus (ICC) and in turn, these neural changes will be carried throughout the central auditory system by the extensive projection network originating in the IC, and will induce modulation in other tinnitus-affected auditory nuclei. The research of this thesis is aimed at determining the feasibility of this tinnitus treatment by assessing the IC as a potential neuromodulation target and identifying optimal stimulation locations and stimulation strategies for achieving maximal suppression. The first study was completed to better understand the auditory coding properties of the IC and to create a three dimensional reconstruction of these functional properties across the entire IC. These results narrowed down the stimulation target to the dorsal cortex of the inferior colliculus (ICD) and produced a tool that could be used to consistently place stimulating and recording electrodes in correct regions in the IC. The second and third studies focused on assessing the best stimulation locations and stimulation paradigms within the ICD, respectively, by stimulating throughout and measuring changes in neural activity in the ICC. These results show that maximal suppression is achieved by stimulation of the rostral-medial region of the ICD using either electrical stimulation only or electrical stimulation paired with acoustic stimulation with an 18 ms delay. These results will guide implementation in human patients. There are already deaf patients who suffer from tinnitus that are being implanted with a deep brain stimulator for hearing restoration called the auditory midbrain implant. Hardware modifications to the auditory midbrain implant have been completed that will allow us to stimulate the ICD and evaluate the effects on the tinnitus percept directly in patients.

Subjects/Keywords: Deep Brain Stimulation; Inferior Colliculus; Neuromodulation; Tinnitus

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APA (6^th Edition):

Offutt, S. (2015). The Inferior Colliculus: A Target for Deep Brain Stimulation for Tinnitus Suppression. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/209122

Chicago Manual of Style (16^th Edition):

Offutt, Sarah. “The Inferior Colliculus: A Target for Deep Brain Stimulation for Tinnitus Suppression.” 2015. Doctoral Dissertation, University of Minnesota. Accessed January 23, 2021. http://hdl.handle.net/11299/209122.

MLA Handbook (7^th Edition):

Offutt, Sarah. “The Inferior Colliculus: A Target for Deep Brain Stimulation for Tinnitus Suppression.” 2015. Web. 23 Jan 2021.

Vancouver:

Offutt S. The Inferior Colliculus: A Target for Deep Brain Stimulation for Tinnitus Suppression. [Internet] [Doctoral dissertation]. University of Minnesota; 2015. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/11299/209122.

Council of Science Editors:

Offutt S. The Inferior Colliculus: A Target for Deep Brain Stimulation for Tinnitus Suppression. [Doctoral Dissertation]. University of Minnesota; 2015. Available from: http://hdl.handle.net/11299/209122

Georgia Tech

23. Darghouth, Naim Richard. Modeling A-current Modulation in Tritonia diomedea.

Degree: MS, Electrical and Computer Engineering, 2004, Georgia Tech

URL: http://hdl.handle.net/1853/7257

► This study uses a conductance-based computer simulation to test the feasibility of a mechanism underlying a newly-described dynamic form of neuromodulation, called spike-timing dependent neuromodulation… (more)

Subjects/Keywords: Neuronal modeling; Neuromodulation

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APA (6^th Edition):

Darghouth, N. R. (2004). Modeling A-current Modulation in Tritonia diomedea. (Masters Thesis). Georgia Tech. Retrieved from http://hdl.handle.net/1853/7257

Chicago Manual of Style (16^th Edition):

Darghouth, Naim Richard. “Modeling A-current Modulation in Tritonia diomedea.” 2004. Masters Thesis, Georgia Tech. Accessed January 23, 2021. http://hdl.handle.net/1853/7257.

MLA Handbook (7^th Edition):

Darghouth, Naim Richard. “Modeling A-current Modulation in Tritonia diomedea.” 2004. Web. 23 Jan 2021.

Vancouver:

Darghouth NR. Modeling A-current Modulation in Tritonia diomedea. [Internet] [Masters thesis]. Georgia Tech; 2004. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1853/7257.

Council of Science Editors:

Darghouth NR. Modeling A-current Modulation in Tritonia diomedea. [Masters Thesis]. Georgia Tech; 2004. Available from: http://hdl.handle.net/1853/7257

University of Cambridge

24. Tang, Sze-Man Clara. The effects of cholinergic and dopaminergic neurons on hippocampal learning and memory processes.

Degree: PhD, 2018, University of Cambridge

URL: https://doi.org/10.17863/CAM.17802 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744462

► Dysfunction of cholinergic and dopaminergic systems has been implicated in memory function de cits that are core pathology and associated features of several neurological disorders.… (more)

▼ Dysfunction of cholinergic and dopaminergic systems has been implicated in memory function de cits that are core pathology and associated features of several neurological disorders. However, in order to develop more effective treatments, it is crucial to better understand how different aspects of learning and memory are modulated by these neuromodulatory systems. Using optogenetic stimulation or silencing, this thesis aims to investigate the effects of cholinergic and dopaminergic modulation on various hippocamal learning and memory processes. To understand how these neuromodulatory systems modulate hippocampal network activity, I first examined their effects on hippocampal local field potentials in urethane-anaesthetised mice. I demonstrated that optogenetic cholinergic activation suppressed slow oscillations, shifting brain activity to a state dominated by theta and gamma oscillations. In contrast, dopaminergic activation suppressed gamma oscillations. Second, to directly probe the effects of neuromodulation on different stages of spatial learning, I acutely activated or inactivated cholinergic or dopaminergic neurons during various behavioural tasks. My findings suggested that cholinergic activation, solely during the reward phase of a long-term spatial memory task, slowed place learning, highlighting the importance of temporally-precise neuromodulation. Moreover, dopaminergic stimulation may enhance place learning of a food rewarded task, supporting a role for dopamine in spatial learning. In addition, I tested the effects of cholinergic and dopaminergic modulation on reversal learning and found that cholinergic inactivation and dopaminergic activation appear to impair this process. Together, these findings emphasise the importance of cholinergic and dopaminergic modulation in learning and memory. They suggest that precise timing of neuromodulator action is critical for optimal learning and memory performance, and that acetylcholine and dopamine support complementary processes that allow for effective learning and adaptation to changing environments.

Subjects/Keywords: 616.8; neuromodulation; learning and memory; network oscillations

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APA (6^th Edition):

Tang, S. C. (2018). The effects of cholinergic and dopaminergic neurons on hippocampal learning and memory processes. (Doctoral Dissertation). University of Cambridge. Retrieved from https://doi.org/10.17863/CAM.17802 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744462

Chicago Manual of Style (16^th Edition):

Tang, Sze-Man Clara. “The effects of cholinergic and dopaminergic neurons on hippocampal learning and memory processes.” 2018. Doctoral Dissertation, University of Cambridge. Accessed January 23, 2021. https://doi.org/10.17863/CAM.17802 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744462.

MLA Handbook (7^th Edition):

Tang, Sze-Man Clara. “The effects of cholinergic and dopaminergic neurons on hippocampal learning and memory processes.” 2018. Web. 23 Jan 2021.

Vancouver:

Tang SC. The effects of cholinergic and dopaminergic neurons on hippocampal learning and memory processes. [Internet] [Doctoral dissertation]. University of Cambridge; 2018. [cited 2021 Jan 23]. Available from: https://doi.org/10.17863/CAM.17802 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744462.

Council of Science Editors:

Tang SC. The effects of cholinergic and dopaminergic neurons on hippocampal learning and memory processes. [Doctoral Dissertation]. University of Cambridge; 2018. Available from: https://doi.org/10.17863/CAM.17802 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744462

University of Sydney

25. Taylor, Matthew. Investigation and Quantification of FES Exercise – Isometric Electromechanics and Perceptions of Its Usage as an Exercise Modality for Various Populations .

Degree: 2018, University of Sydney

URL: http://hdl.handle.net/2123/20435

► Functional Electrical Stimulation (FES) is the triggering of muscle contraction by use of an electrical current. It can be used to give paralyzed individuals several… (more)

Subjects/Keywords: Biomechanics; rehabilitation; neuromodulation; interviews; electrical stimulation

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APA (6^th Edition):

Taylor, M. (2018). Investigation and Quantification of FES Exercise – Isometric Electromechanics and Perceptions of Its Usage as an Exercise Modality for Various Populations . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/20435

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Taylor, Matthew. “Investigation and Quantification of FES Exercise – Isometric Electromechanics and Perceptions of Its Usage as an Exercise Modality for Various Populations .” 2018. Thesis, University of Sydney. Accessed January 23, 2021. http://hdl.handle.net/2123/20435.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Taylor, Matthew. “Investigation and Quantification of FES Exercise – Isometric Electromechanics and Perceptions of Its Usage as an Exercise Modality for Various Populations .” 2018. Web. 23 Jan 2021.

Vancouver:

Taylor M. Investigation and Quantification of FES Exercise – Isometric Electromechanics and Perceptions of Its Usage as an Exercise Modality for Various Populations . [Internet] [Thesis]. University of Sydney; 2018. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/2123/20435.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Taylor M. Investigation and Quantification of FES Exercise – Isometric Electromechanics and Perceptions of Its Usage as an Exercise Modality for Various Populations . [Thesis]. University of Sydney; 2018. Available from: http://hdl.handle.net/2123/20435

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Kent State University

26. Cooperrider, Jessica L. Deep Brain Stimulation of the Lateral Cerebellar Nucleus of Rodents Following Ischemia Promotes Functional Recovery and Synaptic Plasticity in the Perilesional Cortex.

Degree: MS, College of Arts and Sciences / School of Biomedical Sciences, 2013, Kent State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=kent1374716388

► Stroke is currently the leading cause of disability in the United States. More effective forms of neurorehabilitation than are currently employed are thus necessary to… (more)

Subjects/Keywords: Neurosciences; deep brain stimulation; stroke; neuromodulation

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APA (6^th Edition):

Cooperrider, J. L. (2013). Deep Brain Stimulation of the Lateral Cerebellar Nucleus of Rodents Following Ischemia Promotes Functional Recovery and Synaptic Plasticity in the Perilesional Cortex. (Masters Thesis). Kent State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=kent1374716388

Chicago Manual of Style (16^th Edition):

Cooperrider, Jessica L. “Deep Brain Stimulation of the Lateral Cerebellar Nucleus of Rodents Following Ischemia Promotes Functional Recovery and Synaptic Plasticity in the Perilesional Cortex.” 2013. Masters Thesis, Kent State University. Accessed January 23, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=kent1374716388.

MLA Handbook (7^th Edition):

Cooperrider, Jessica L. “Deep Brain Stimulation of the Lateral Cerebellar Nucleus of Rodents Following Ischemia Promotes Functional Recovery and Synaptic Plasticity in the Perilesional Cortex.” 2013. Web. 23 Jan 2021.

Vancouver:

Cooperrider JL. Deep Brain Stimulation of the Lateral Cerebellar Nucleus of Rodents Following Ischemia Promotes Functional Recovery and Synaptic Plasticity in the Perilesional Cortex. [Internet] [Masters thesis]. Kent State University; 2013. [cited 2021 Jan 23]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=kent1374716388.

Council of Science Editors:

Cooperrider JL. Deep Brain Stimulation of the Lateral Cerebellar Nucleus of Rodents Following Ischemia Promotes Functional Recovery and Synaptic Plasticity in the Perilesional Cortex. [Masters Thesis]. Kent State University; 2013. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=kent1374716388

New Jersey Institute of Technology

27. Fox, David Michael. Biophysical mechanisms of frequency-dependence and its neuromodulation in neurons in oscillatory networks.

Degree: PhD, Federated Department of Biological Sciences, 2017, New Jersey Institute of Technology

URL: https://digitalcommons.njit.edu/dissertations/52

► In response to oscillatory input, many isolated neurons exhibit a preferred frequency response in their voltage amplitude and phase shift. Membrane potential resonance (MPR),… (more)

▼ In response to oscillatory input, many isolated neurons exhibit a preferred frequency response in their voltage amplitude and phase shift. Membrane potential resonance (MPR), a maximum amplitude in a neuron’s input impedance at a non-zero frequency, captures the essential subthreshold properties of a neuron, which may provide a coordinating mechanism for organizing the activity of oscillatory neuronal networks around a given frequency. In the pyloric central pattern generator network of the crab Cancer borealis, for example, the pacemaker group pyloric dilator neurons show MPR at a frequency that is correlated with the network frequency. This dissertation uses the crab pyloric CPG to examine how, in one neuron type, interactions of ionic currents, even when expressed at different levels, can produce consistent MPR properties, how MPR properties are modified by neuromodulators and how such modifications may lead to distinct functional effects at different network frequencies. In the first part of this dissertation it is demonstrated that, despite the extensive variability of individual ionic currents in a neuron type such as PD, these currents can generate a consistent impedance profile as a function of input frequency and therefore result in stable MPR properties. Correlated changes in ionic current parameters are associated with the dependence of MPR on the membrane potential range. Synaptic inputs or neuromodulators that shift the membrane potential range can modify the interaction of multiple resonant currents and therefore shift the MPR frequency. Neuromodulators change the properties of voltage-dependent ionic currents. Since ionic current interactions are nonlinear, the modulation of excitability and the impedance profile may depend on all ionic current types expressed by the neuron. MPR is generated by the interaction of positive and negative feedback effects due to fast amplifying and slower resonant currents. Neuromodulators can modify existing MPR properties to generate antiresonance (a minimum amplitude response). In the second part of this dissertation, it is shown that the neuropeptide proctolin produces antiresonance in the follower lateral pyloric neuron, but not in the PD neuron. This finding is inconsistent with the known influences of proctolin. However, a novel proctolin-activated ionic current is shown to produce the antiresonance. Using linear models, antiresonance is then demonstrated to amplify MPR in synaptic partner neurons, indicating a potential function in the pyloric network. Neuromodulators are state dependent, so that their action may depend on the prior activity history of the network. It is shown that state-dependence may arise in part from the time-dependence of an inactivating inward current targeted by the neuromodulator proctolin. Due to the kinetics of inactivation, this current advances the burst phase and increases the duty cycle of the neuron, but mainly at higher network frequencies. These results demonstrate that the effect of… Advisors/Committee Members: Farzan Nadim, Horacio G. Rotstein, Gal Haspel.

Subjects/Keywords: Resonance; Oscillation; Neuromodulation; Modeling; Optimization; Stomatogastric; Biology

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APA (6^th Edition):

Fox, D. M. (2017). Biophysical mechanisms of frequency-dependence and its neuromodulation in neurons in oscillatory networks. (Doctoral Dissertation). New Jersey Institute of Technology. Retrieved from https://digitalcommons.njit.edu/dissertations/52

Chicago Manual of Style (16^th Edition):

Fox, David Michael. “Biophysical mechanisms of frequency-dependence and its neuromodulation in neurons in oscillatory networks.” 2017. Doctoral Dissertation, New Jersey Institute of Technology. Accessed January 23, 2021. https://digitalcommons.njit.edu/dissertations/52.

MLA Handbook (7^th Edition):

Fox, David Michael. “Biophysical mechanisms of frequency-dependence and its neuromodulation in neurons in oscillatory networks.” 2017. Web. 23 Jan 2021.

Vancouver:

Fox DM. Biophysical mechanisms of frequency-dependence and its neuromodulation in neurons in oscillatory networks. [Internet] [Doctoral dissertation]. New Jersey Institute of Technology; 2017. [cited 2021 Jan 23]. Available from: https://digitalcommons.njit.edu/dissertations/52.

Council of Science Editors:

Fox DM. Biophysical mechanisms of frequency-dependence and its neuromodulation in neurons in oscillatory networks. [Doctoral Dissertation]. New Jersey Institute of Technology; 2017. Available from: https://digitalcommons.njit.edu/dissertations/52

Delft University of Technology

28. Wang, Shuang (author). An ultrasound receiver channel for vagus nerve imaging.

Degree: 2020, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:52f376d4-a8e2-4242-9aef-2c991c44c51c

►

The neuromodulation modality based on the focused ultrasonic stimulation (FUS) has gained its interests for being non-invasive while having unprecedented high spatial resolution and deep… (more)

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The neuromodulation modality based on the focused ultrasonic stimulation (FUS) has gained its interests for being non-invasive while having unprecedented high spatial resolution and deep penetration. The commercially available image-guided FUS device for neuromodulation setups are normally bulky, by employing an 1-D array transducer element to produce the FUS and a separate ultrasonic scanning device for B-Mode imaging purpose. Aiming to design a wearable neural stimulating device for human's vagus nerve, a miniature device with 2-D array transducers is proposed to replace the conventional setup as it can statically generate FUS. The device is capable of locating the vagus nerve and non-invasively stimulating the nerve by integrating the imaging system and the neural modulation system together. In typical neuroFUS applications, an ultrasound image is obtained prior to neuromodulation, to obtain the precise coordinates of the nerve. This project presents a front-end CMOS circuit for the 2-D array ultrasound-based system for imaging the vagus nerve, as a part of the full system for the neuromodulation capabilities. The imaging signal chain enables the local digitization, allowing a robust digital beamforming and readout signal. The front-end CMOS circuit mainly contains three functions: the low-noise amplifier (LNA), time-gain-compensation (TGC) function block and the analog-to-digital converter (ADC). The front-end received chain employs the power- and area-efficient design consideration, interfacing the 12 MHz piezoelectric signal from the PMN-PT transducer element. The mixed signal system is implemented in 0.18 micrometer TSMC CMOS technology and operating under the 1.8 V voltage for both analog and digital supply. The analog front end (AFE) has the variable voltage gains up to 62 dB to interface the 1 V full scale range of the ADC. For ultra low power and chip area considerations, the ADC topology is a 6-bit single-ended common-voltage based successive-approximation (SAR) ADC with the typical sample rate 50 MS/s. The SAR ADC consumes 415.8 microW and achieves dynamic performances of 37 dB SNDR and 49.4 dB SFDR. The total power consumption of the signal chain is 1.3 mW and the layout chip area consumes 150 micrometer square.

Electrical Engineering | Microelectronics

Advisors/Committee Members: Lopes Marta da Costa, T.M. (mentor), Serdijn, W.A. (mentor), Delft University of Technology (degree granting institution).

Subjects/Keywords: ultrasound neuromodulation; receive digitization; SAR ADC

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, S. (. (2020). An ultrasound receiver channel for vagus nerve imaging. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:52f376d4-a8e2-4242-9aef-2c991c44c51c

Chicago Manual of Style (16^th Edition):

Wang, Shuang (author). “An ultrasound receiver channel for vagus nerve imaging.” 2020. Masters Thesis, Delft University of Technology. Accessed January 23, 2021. http://resolver.tudelft.nl/uuid:52f376d4-a8e2-4242-9aef-2c991c44c51c.

MLA Handbook (7^th Edition):

Wang, Shuang (author). “An ultrasound receiver channel for vagus nerve imaging.” 2020. Web. 23 Jan 2021.

Vancouver:

Wang S(. An ultrasound receiver channel for vagus nerve imaging. [Internet] [Masters thesis]. Delft University of Technology; 2020. [cited 2021 Jan 23]. Available from: http://resolver.tudelft.nl/uuid:52f376d4-a8e2-4242-9aef-2c991c44c51c.

Council of Science Editors:

Wang S(. An ultrasound receiver channel for vagus nerve imaging. [Masters Thesis]. Delft University of Technology; 2020. Available from: http://resolver.tudelft.nl/uuid:52f376d4-a8e2-4242-9aef-2c991c44c51c

29. Geiger, Maxime. Etude des effets de la stimulation électrique transcrânienne en courant continu (tDCS) sur la fonction motrice volontaire et semi-automatique chez des patients hémiparétiques post AVC : Impact of transcranial direct curent stimulation on voluntary and semi-automatic movement in patient with stroke.

Degree: Docteur es, Sciences du sport et du mouvement humain, 2019, Université Paris-Saclay (ComUE)

URL: http://www.theses.fr/2019SACLS072

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Chez les patients hémiparétiques chroniques, la tDCS a été testée sur diverses tâches du membre inférieur, montrant des résultats intéressants, mais parfois contradictoires. Cependant, les… (more)

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Chez les patients hémiparétiques chroniques, la tDCS a été testée sur diverses tâches du membre inférieur, montrant des résultats intéressants, mais parfois contradictoires. Cependant, les effets de la tDCS sur la fonction motrice volontaire (extension de genou) et semi-automatique (locomotion) chez des patients hémiparétiques ne sont pas encore totalement connus. L’objet de ce travail était d’évaluer contre placébo les effets de la tDCS en polarité anodale sur les fonctions motrices volontaires et semi-automatiques, chez des patients hémiparétiques. L’étude comporte deux parties : la première a pour but d’évaluer l’effet contre placébo de la tDCS bilatérale sur la force volontaire maximale du quadriceps parétique par isocinétisme, la seconde a pour objectif d’étudier les effets contre placébo des effets de la tDCS unilatérale sur la marche par analyse tridimensionnelle du mouvement. Les résultats ont montré une absence d’effet de la tDCS sur les deux types de mouvements étudiés. De plus, la tDCS n’a pas eu d’effet sur la spasticité du quadriceps ni sur la performance aux tests fonctionnels des patients hémiparétiques. Cela suggère qu’il n’y a pas d’intérêt à l’utilisation de la tDCS bilatérale pour améliorer une performance motrice maximale (l’extension de genou) ni de la tDCS unilatérale pour améliorer un mouvement semi-automatique (la locomotion) chez les patients hémiparétiques chroniques. Les perspectives envisagées sont de reconduire ces expérimentations chez un groupe homogène de patients hémiparétiques en phase aigüe ou subaigüe afin de potentialiser les phénomènes plastiques post-lésionnels. Ceci permettra de renforcer ou non l’intérêt de l’utilisation de la tDCS chez les patients hémiparétiques afin d’améliorer leurs performances motrices.

In chronic hemiparetic patients, the use of tDCS has been tested on various lower limb tasks, showing interesting but sometimes contradictory results. However, the effects of tDCS on voluntary (knee extension) and semi-automatic (locomotion) motor function in hemiparetic patients are not yet fully known. The purpose of this work was to quantify the effects of tDCS in anodal polarity on the voluntary and semi-automatic motor functions in placebo-controlled studies. The study is divided into two parts: the first aims to evaluate the effect against placebo of bilateral tDCS on the maximal voluntary force of the paretic quadriceps by isokinetic assessment, the second aims to study the effects against placebo of unilateral tDCS on the gait of chronic hemiparetic patients, assessed by three-dimensional gait analysis. The results showed an absence of effect of tDCS on the two types of movements studied. In addition, tDCS had no effect on quadriceps spasticity or functional test performance in hemiparetic patients. This suggests that there is no interest in using bilateral tDCS to improve maximal motor performance (knee extension) or unilateral tDCS to improve semi-automatic movement (locomotion) in chronic hemiparetic patients. The envisaged perspectives are to continue these…

Advisors/Committee Members: Roche, Nicolas (thesis director), Do, Manh-Cuong (thesis director).

Subjects/Keywords: AVC; TDCS; Locomotion; Force; Hémiparésie; Neuromodulation; Stroke; TDCS; Locomotion; Strenght; Hemiparesis; Neuromodulation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Geiger, M. (2019). Etude des effets de la stimulation électrique transcrânienne en courant continu (tDCS) sur la fonction motrice volontaire et semi-automatique chez des patients hémiparétiques post AVC : Impact of transcranial direct curent stimulation on voluntary and semi-automatic movement in patient with stroke. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2019SACLS072

Chicago Manual of Style (16^th Edition):

Geiger, Maxime. “Etude des effets de la stimulation électrique transcrânienne en courant continu (tDCS) sur la fonction motrice volontaire et semi-automatique chez des patients hémiparétiques post AVC : Impact of transcranial direct curent stimulation on voluntary and semi-automatic movement in patient with stroke.” 2019. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed January 23, 2021. http://www.theses.fr/2019SACLS072.

MLA Handbook (7^th Edition):

Geiger, Maxime. “Etude des effets de la stimulation électrique transcrânienne en courant continu (tDCS) sur la fonction motrice volontaire et semi-automatique chez des patients hémiparétiques post AVC : Impact of transcranial direct curent stimulation on voluntary and semi-automatic movement in patient with stroke.” 2019. Web. 23 Jan 2021.

Vancouver:

Geiger M. Etude des effets de la stimulation électrique transcrânienne en courant continu (tDCS) sur la fonction motrice volontaire et semi-automatique chez des patients hémiparétiques post AVC : Impact of transcranial direct curent stimulation on voluntary and semi-automatic movement in patient with stroke. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2019. [cited 2021 Jan 23]. Available from: http://www.theses.fr/2019SACLS072.

Council of Science Editors:

Geiger M. Etude des effets de la stimulation électrique transcrânienne en courant continu (tDCS) sur la fonction motrice volontaire et semi-automatique chez des patients hémiparétiques post AVC : Impact of transcranial direct curent stimulation on voluntary and semi-automatic movement in patient with stroke. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2019. Available from: http://www.theses.fr/2019SACLS072

30. Yapo, Cédric. Adaptations de la cascade de signalisation AMPc/PKA dans le striatum au cours de la maladie de Parkinson et de son traitement par la L-DOPA : étude par imagerie de biosenseurs sur un modèle animal : Adaptations of the cAMP/PKA signaling cascade in the striatal medium-sized spiny neurons during Parkinson's disease and its treatment by L-DOPA : study performed using biosensor imaging on a mouse model.

Degree: Docteur es, Neurosciences, 2018, Sorbonne université

URL: http://www.theses.fr/2018SORUS603

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Les signaux neuromodulateurs induisent une adaptation des fonctions neuronales par le biais de mécanismes d’intégration dynamiques complexes. Parmi les voies de signalisation intracellulaires, celle de… (more)

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Les signaux neuromodulateurs induisent une adaptation des fonctions neuronales par le biais de mécanismes d’intégration dynamiques complexes. Parmi les voies de signalisation intracellulaires, celle de l’AMPc/PKA joue un rôle essentiel dans la réponse cellulaire à la dopamine. Pour analyser ces processus d’intégration, nous combinons l’imagerie de biosenseurs dans des préparations ex vivo de tranches de cerveau de souris avec de la modélisation de la signalisation intracellulaire dans les neurones D1 et D2 striataux. Dans une première partie de mon travail de thèse, nous analysons la dynamique de la signalisation striatale en réponse à des stimulations dopaminergiques transitoires telles celles associées aux récompenses. Nous montrons par imagerie que, contrairement à ce qui est communément admis, les récepteurs D2 à la dopamine permettent la détection de dopamine phasique au niveau de l’AMPc. De plus, les simulations suggèrent que les neurones D2 pourraient détecter une diminution du niveau de dopamine tonique, indicateur d’une situation aversive chez l’animal. Ce travail a fait l’objet d’une publication (Yapo et al., J. Physiol 2017). Dans une deuxième partie, nous avons analysé l’effet dans le noyau de ces stimulations dopaminergiques rapides. En comparaison avec les neurones du cortex, nous montrons que les neurones du striatum disposent d’un mécanisme de contrôle en-avant (“feed forward”) qui renforce les réponses PKA nucléaires. Cette situation originale, à l’opposé des rétrocontrôles homéostatiques habituels en biologie, amène à une réponse du noyau tout ou rien, extrêmement sensible. Nous pensons que ce mécanisme est impliqué dans la détection des signaux dopaminergiques transitoires. Ce travail a été publié dans un article (Yapo et al., J Cell Science 2018). Enfin une troisième partie, sous forme de résultats préliminaires, consistait à analyser l’adaptation des neurones du striatum à la perte des afférences dopaminergiques, caractéristique de la maladie de Parkinson. Nous avons observé l’hypersensibilité à la dopamine affectant les neurones D1, largement décrite dans la littérature. De plus, nous montrons que les neurones du striatum présentent une activité phosphodiestérase accrue. Une meilleure compréhension de ces adaptations pathologiques pourrait mener à de nouvelles stratégies thérapeutiques.

Neuromodulatory signals trigger adaptations in neuronal functions via complex integrative properties. Among the various existing intracellular signaling pathways, the cAMP/PKA cascade plays a critical role in the cellular response to dopamine. To analyze these integrative processes, we combine biosensor imaging in mouse brain slices with in silico modelisation of the intracellular signaling in D1 and D2 medium-sized spiny neurons. In a first part of my thesis work, we analyze the dynamics of cAMP/PKA signaling in striatal neurons stimulated by transient dopaminergic signals, such as those associated with reward. With imaging we show that…

Advisors/Committee Members: Vincent, Pierre (thesis director), Castro, Liliana (thesis director).

Subjects/Keywords: Neuromodulation; Striatum; Dopamine; Parkinson; Imagerie; Biosenseurs; Neuromodulation; Striatum; Dopamine; Parkinson's disease; 571.6

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yapo, C. (2018). Adaptations de la cascade de signalisation AMPc/PKA dans le striatum au cours de la maladie de Parkinson et de son traitement par la L-DOPA : étude par imagerie de biosenseurs sur un modèle animal : Adaptations of the cAMP/PKA signaling cascade in the striatal medium-sized spiny neurons during Parkinson's disease and its treatment by L-DOPA : study performed using biosensor imaging on a mouse model. (Doctoral Dissertation). Sorbonne université. Retrieved from http://www.theses.fr/2018SORUS603

Chicago Manual of Style (16^th Edition):

Yapo, Cédric. “Adaptations de la cascade de signalisation AMPc/PKA dans le striatum au cours de la maladie de Parkinson et de son traitement par la L-DOPA : étude par imagerie de biosenseurs sur un modèle animal : Adaptations of the cAMP/PKA signaling cascade in the striatal medium-sized spiny neurons during Parkinson's disease and its treatment by L-DOPA : study performed using biosensor imaging on a mouse model.” 2018. Doctoral Dissertation, Sorbonne université. Accessed January 23, 2021. http://www.theses.fr/2018SORUS603.

MLA Handbook (7^th Edition):

Yapo, Cédric. “Adaptations de la cascade de signalisation AMPc/PKA dans le striatum au cours de la maladie de Parkinson et de son traitement par la L-DOPA : étude par imagerie de biosenseurs sur un modèle animal : Adaptations of the cAMP/PKA signaling cascade in the striatal medium-sized spiny neurons during Parkinson's disease and its treatment by L-DOPA : study performed using biosensor imaging on a mouse model.” 2018. Web. 23 Jan 2021.

Vancouver:

Yapo C. Adaptations de la cascade de signalisation AMPc/PKA dans le striatum au cours de la maladie de Parkinson et de son traitement par la L-DOPA : étude par imagerie de biosenseurs sur un modèle animal : Adaptations of the cAMP/PKA signaling cascade in the striatal medium-sized spiny neurons during Parkinson's disease and its treatment by L-DOPA : study performed using biosensor imaging on a mouse model. [Internet] [Doctoral dissertation]. Sorbonne université; 2018. [cited 2021 Jan 23]. Available from: http://www.theses.fr/2018SORUS603.

Council of Science Editors:

Yapo C. Adaptations de la cascade de signalisation AMPc/PKA dans le striatum au cours de la maladie de Parkinson et de son traitement par la L-DOPA : étude par imagerie de biosenseurs sur un modèle animal : Adaptations of the cAMP/PKA signaling cascade in the striatal medium-sized spiny neurons during Parkinson's disease and its treatment by L-DOPA : study performed using biosensor imaging on a mouse model. [Doctoral Dissertation]. Sorbonne université; 2018. Available from: http://www.theses.fr/2018SORUS603

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