subject:(Neuroglia mesh )

Freie Universität Berlin

1. Krämer, Nadine. Developmental molecular factors of the dentate gyrus in mice.

Degree: 2008, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-8178

► The dentate gyrus provides a good model for diverse areas of research concerning the cortical development, especially neurogenesis, neuronal migration, regionalization, axonal guidance and neuronal… (more)

▼ The dentate gyrus provides a good model for diverse areas of research concerning the cortical development, especially neurogenesis, neuronal migration, regionalization, axonal guidance and neuronal plasticity. Furthermore, the dentate gyrus has the special ability to produce functional neurons out of neuronal precursors the whole life long. Therefore it is an interesting object of research for potential neuronal processes of regeneration in the cortex. The aim of this study was to identify molecular factors of dentate gyrus development and to analyse their functions. The subject of the experiments was a comparison of expression patterns from Emx2-/- mutant versus wildtype mouse, because the transcription factor Emx2 plays a key role in hippocampal development. Thus, mice deficient in this factor show very specific developmental alterations in the hippocampus, which leads to the absence of a morphologically visible dentate gyrus in these Emx2-/- mutants. First some known genes, whose functions had already been described in literature extensively, were analysed during development by in situ hybridisation. Thereby investigating the different functional circuits like proliferation, differentiation and migration as well as the structural alterations of the dentate gyrus and the adjacent hippocampal fissure and marginal zone were of particular interest. Furthermore some candidate genes, for which a putative relation to Emx2 had not been described previously, were identified by screening microarrays. The results show that, in the Emx2-/- mutant dentate gyrus, the proneural cascade of bHLH genes is present, but abnormally confined to the germinal layer, the neuronal and glial migrating precursors are nearly absent, the glial scaffold is defective, the few produced astrocytes and granule cells are not able to migrate to their proper destination and in addition the granule cells are deficiently differentiated. The glial scaffolding is also lacking in the Emx2-/- mutant developing hippocampal fissure. The inner marginal zone (IMZ) seems to be developed properly, in contrast the outer marginal zone (OMZ) as well as the dentate marginal zone (DMZ) is atrophic. Most of the Reln-expressing cells that should occupy the OMZ and DMZ are missing, except a specific subpopulation, characterized by using additional markers, probably born in the hem and for which Emx2 is not essentially required. The microarray analysis reveals a group of genes whose expression is reduced in the Emx2-/- hippocampus. For most of them a putative relation to Emx2 pathways had not been recognized previously. Some candidates are development genes or are involved in functional maturation and show expression in the hippocampal plate and/or developing dentate gyrus. A second group of candidates labels neuronal, glial or vascular structures in the OMZ and likely represent markers for cell populations specifically absent in the mutant. The lack of these genes points at different pathways and processes altered in the Emx2-/-mutant, particularly the Notch and… Advisors/Committee Members: n (gender), Univ.-Prof. Dr. H. Martens (firstReferee), Univ.-Prof. Dr. T. Skutella (furtherReferee), Univ.-Prof. Dr. H. Fink (furtherReferee).

Subjects/Keywords: Mice, hippocampus, embryonic development, neurons, migration, genes; Genes, Homeobox (MeSH); gene expression; Gene Expression Regulation, Developmental (MeSH); transcription factors, neuroglia, polymerase chain reaction, DNA microarrays, in-situ hybridization; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft

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APA (6^th Edition):

Krämer, N. (2008). Developmental molecular factors of the dentate gyrus in mice. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-8178

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Krämer, Nadine. “Developmental molecular factors of the dentate gyrus in mice.” 2008. Thesis, Freie Universität Berlin. Accessed January 15, 2021. http://dx.doi.org/10.17169/refubium-8178.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Krämer, Nadine. “Developmental molecular factors of the dentate gyrus in mice.” 2008. Web. 15 Jan 2021.

Vancouver:

Krämer N. Developmental molecular factors of the dentate gyrus in mice. [Internet] [Thesis]. Freie Universität Berlin; 2008. [cited 2021 Jan 15]. Available from: http://dx.doi.org/10.17169/refubium-8178.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Krämer N. Developmental molecular factors of the dentate gyrus in mice. [Thesis]. Freie Universität Berlin; 2008. Available from: http://dx.doi.org/10.17169/refubium-8178

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Florida

2. Boyd, Frederick Tilghman, 1959-. Characterization and physiological significance of brain insulin receptors.

Degree: 1985, University of Florida

URL: https://ufdc.ufl.edu/AA00053670

Subjects/Keywords: Astrocytes; Brain; Cells; Cultured cells; Insulin; Neuroglia; Neurons; Norepinephrine; Rats; Receptors; Binding Sites ( mesh ); Brain Chemistry ( mesh ); Physiology thesis Ph.D ( mesh ); Receptor, Insulin – physiology ( mesh )

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Boyd, Frederick Tilghman, 1. (1985). Characterization and physiological significance of brain insulin receptors. (Thesis). University of Florida. Retrieved from https://ufdc.ufl.edu/AA00053670

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Boyd, Frederick Tilghman, 1959-. “Characterization and physiological significance of brain insulin receptors.” 1985. Thesis, University of Florida. Accessed January 15, 2021. https://ufdc.ufl.edu/AA00053670.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Boyd, Frederick Tilghman, 1959-. “Characterization and physiological significance of brain insulin receptors.” 1985. Web. 15 Jan 2021.

Vancouver:

Boyd, Frederick Tilghman 1. Characterization and physiological significance of brain insulin receptors. [Internet] [Thesis]. University of Florida; 1985. [cited 2021 Jan 15]. Available from: https://ufdc.ufl.edu/AA00053670.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Boyd, Frederick Tilghman 1. Characterization and physiological significance of brain insulin receptors. [Thesis]. University of Florida; 1985. Available from: https://ufdc.ufl.edu/AA00053670

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Florida

3. Daniels, Kellye K., 1967-. Properties of high-affinity L-Glutamate transport in glial- and neuronal-enriched fractions from rat brain Kellye K. Daniels.

Degree: 1997, University of Florida

URL: https://ufdc.ufl.edu/AA00031499

Subjects/Keywords: Brain; Enzymes; Neuroglia; Neurons; Phorbol esters; Phosphatases; Phosphorylation; Protein isoforms; Rats; Synaptosomes; Biological Transport – physiology ( mesh ); Brain ( mesh ); Cell Aging ( mesh ); Department of Neuroscience thesis Ph.D ( mesh ); Glutamates – metabolism ( mesh ); Glutamates – physiology ( mesh ); Neuroglia ( mesh ); Neurons ( mesh ); Neurotransmitter Uptake Inhibitors – pharmacokinetics ( mesh ); Phosphorylation ( mesh ); Protein Kinase C ( mesh ); Rats ( mesh ); Research ( mesh ); Subcellular Fractions – analysis ( mesh ); Subcellular Fractions – isolation &; purification ( mesh )

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Daniels, Kellye K., 1. (1997). Properties of high-affinity L-Glutamate transport in glial- and neuronal-enriched fractions from rat brain Kellye K. Daniels. (Thesis). University of Florida. Retrieved from https://ufdc.ufl.edu/AA00031499

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Daniels, Kellye K., 1967-. “Properties of high-affinity L-Glutamate transport in glial- and neuronal-enriched fractions from rat brain Kellye K. Daniels.” 1997. Thesis, University of Florida. Accessed January 15, 2021. https://ufdc.ufl.edu/AA00031499.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Daniels, Kellye K., 1967-. “Properties of high-affinity L-Glutamate transport in glial- and neuronal-enriched fractions from rat brain Kellye K. Daniels.” 1997. Web. 15 Jan 2021.

Vancouver:

Daniels, Kellye K. 1. Properties of high-affinity L-Glutamate transport in glial- and neuronal-enriched fractions from rat brain Kellye K. Daniels. [Internet] [Thesis]. University of Florida; 1997. [cited 2021 Jan 15]. Available from: https://ufdc.ufl.edu/AA00031499.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Daniels, Kellye K. 1. Properties of high-affinity L-Glutamate transport in glial- and neuronal-enriched fractions from rat brain Kellye K. Daniels. [Thesis]. University of Florida; 1997. Available from: https://ufdc.ufl.edu/AA00031499

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Florida

4. Richards-Sumners, Elaine Mary, 1957-. Catecholamine and angiotensin II interactions in primary cultures of brain cells.

Degree: 1988, University of Florida

URL: https://ufdc.ufl.edu/AA00054447

Subjects/Keywords: Brain; Catecholamines; Cultured cells; Incubation; Insulin; Neuroglia; Neurons; Norepinephrine; Rats; Receptors; Angiotensin II – physiology ( mesh ); Brain Chemistry ( mesh ); Catecholamines – physiology ( mesh ); Cells, Cultured ( mesh ); Physiology thesis Ph.D ( mesh )

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Richards-Sumners, Elaine Mary, 1. (1988). Catecholamine and angiotensin II interactions in primary cultures of brain cells. (Thesis). University of Florida. Retrieved from https://ufdc.ufl.edu/AA00054447

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Richards-Sumners, Elaine Mary, 1957-. “Catecholamine and angiotensin II interactions in primary cultures of brain cells.” 1988. Thesis, University of Florida. Accessed January 15, 2021. https://ufdc.ufl.edu/AA00054447.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Richards-Sumners, Elaine Mary, 1957-. “Catecholamine and angiotensin II interactions in primary cultures of brain cells.” 1988. Web. 15 Jan 2021.

Vancouver:

Richards-Sumners, Elaine Mary 1. Catecholamine and angiotensin II interactions in primary cultures of brain cells. [Internet] [Thesis]. University of Florida; 1988. [cited 2021 Jan 15]. Available from: https://ufdc.ufl.edu/AA00054447.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Richards-Sumners, Elaine Mary 1. Catecholamine and angiotensin II interactions in primary cultures of brain cells. [Thesis]. University of Florida; 1988. Available from: https://ufdc.ufl.edu/AA00054447

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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