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You searched for subject:(Narcotic Antagonists). Showing records 1 – 3 of 3 total matches.

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The Ohio State University

1. Liao, Sam Hui-tseh. Pharmacokinetics of naltrexone and its conjugated metabolites in dogs and rabbits : a study of biliary excretion and enterohepatic recycling.

Degree: PhD, Graduate School, 1979, The Ohio State University

Subjects/Keywords: Health Sciences; Narcotic antagonists; Naloxone

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APA (6th Edition):

Liao, S. H. (1979). Pharmacokinetics of naltrexone and its conjugated metabolites in dogs and rabbits : a study of biliary excretion and enterohepatic recycling. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1487085764395316

Chicago Manual of Style (16th Edition):

Liao, Sam Hui-tseh. “Pharmacokinetics of naltrexone and its conjugated metabolites in dogs and rabbits : a study of biliary excretion and enterohepatic recycling.” 1979. Doctoral Dissertation, The Ohio State University. Accessed February 26, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487085764395316.

MLA Handbook (7th Edition):

Liao, Sam Hui-tseh. “Pharmacokinetics of naltrexone and its conjugated metabolites in dogs and rabbits : a study of biliary excretion and enterohepatic recycling.” 1979. Web. 26 Feb 2020.

Vancouver:

Liao SH. Pharmacokinetics of naltrexone and its conjugated metabolites in dogs and rabbits : a study of biliary excretion and enterohepatic recycling. [Internet] [Doctoral dissertation]. The Ohio State University; 1979. [cited 2020 Feb 26]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1487085764395316.

Council of Science Editors:

Liao SH. Pharmacokinetics of naltrexone and its conjugated metabolites in dogs and rabbits : a study of biliary excretion and enterohepatic recycling. [Doctoral Dissertation]. The Ohio State University; 1979. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1487085764395316

2. 櫻庭, 茂樹. Donepezil reverses buprenorphine-induced central respiratory depression in anesthetized rabbits. : 全身麻酔下家兎を用いたブプレノルフィンによる中枢性呼吸抑制に対するドネペジルによる拮抗作用.

Degree: 博士(歯学), 2016, Kanagawa Dental University / 神奈川歯科大学

Buprenorphine is a mixed opioid receptor agonist-antagonist used in acute and chronic pain management. Although this agent's analgesic effect increases in a dose-dependent manner, buprenorphine-induced respiratory depression shows a marked ceiling effect at higher doses, which is considered to be an indicator of safety. Nevertheless, cases of overdose mortality or severe respiratory depression associated with buprenorphine use have been reported. Naloxone can reverse buprenorphine-induced respiratory depression, but is slow-acting and unstable, meaning that new drug candidates able to specifically antagonize buprenorphine-induced respiratory depression are needed in order to enable maximal analgesic effect without respiratory depression. Acetylcholine is an excitatory neurotransmitter in central respiratory control. We previously showed that a long-acting acetylcholinesterase inhibitor, donepezil, antagonizes morphine-induced respiratory depression. We have now investigated how donepezil affects buprenorphine-induced respiratory depression in anesthetized, paralyzed, and artificially ventilated rabbits. We measured phrenic nerve discharge as an Index of respiratory rate and amplitude, and compared discharges following the injection of buprenorphine with discharges following the injection of donepezil. Buprenorphine-induced suppression of the respiratory rate and respiratory amplitude was antagonized by donepezil (78.4 +/- 4.8 %, 92.3% +/- 22.8 % of control, respectively). These findings indicate that systemically administered donepezil restores buprenorphine-induced respiratory depression in anesthetized rabbits.

2013

Subjects/Keywords: Animals; Buprenorphine; Cholinesterase Inhibitors; Indans; Male; Narcotic Antagonists; Phrenic Nerve; Piperidines; Rabbits; Respiratory Insufficiency

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APA (6th Edition):

櫻庭, . (2016). Donepezil reverses buprenorphine-induced central respiratory depression in anesthetized rabbits. : 全身麻酔下家兎を用いたブプレノルフィンによる中枢性呼吸抑制に対するドネペジルによる拮抗作用. (Thesis). Kanagawa Dental University / 神奈川歯科大学. Retrieved from http://id.nii.ac.jp/1421/00000908/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

櫻庭, 茂樹. “Donepezil reverses buprenorphine-induced central respiratory depression in anesthetized rabbits. : 全身麻酔下家兎を用いたブプレノルフィンによる中枢性呼吸抑制に対するドネペジルによる拮抗作用.” 2016. Thesis, Kanagawa Dental University / 神奈川歯科大学. Accessed February 26, 2020. http://id.nii.ac.jp/1421/00000908/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

櫻庭, 茂樹. “Donepezil reverses buprenorphine-induced central respiratory depression in anesthetized rabbits. : 全身麻酔下家兎を用いたブプレノルフィンによる中枢性呼吸抑制に対するドネペジルによる拮抗作用.” 2016. Web. 26 Feb 2020.

Vancouver:

櫻庭 . Donepezil reverses buprenorphine-induced central respiratory depression in anesthetized rabbits. : 全身麻酔下家兎を用いたブプレノルフィンによる中枢性呼吸抑制に対するドネペジルによる拮抗作用. [Internet] [Thesis]. Kanagawa Dental University / 神奈川歯科大学; 2016. [cited 2020 Feb 26]. Available from: http://id.nii.ac.jp/1421/00000908/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

櫻庭 . Donepezil reverses buprenorphine-induced central respiratory depression in anesthetized rabbits. : 全身麻酔下家兎を用いたブプレノルフィンによる中枢性呼吸抑制に対するドネペジルによる拮抗作用. [Thesis]. Kanagawa Dental University / 神奈川歯科大学; 2016. Available from: http://id.nii.ac.jp/1421/00000908/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Hain, Heather S. Quantitative trait loci mapping analysis for baseline nociceptive sensitivity and morphine-induced antinociception on the writhing assay.

Degree: PhD, 1999, Oregon Health Sciences University

Subjects/Keywords: Nociceptors  – drug effects; Chromosome Mapping; Morphine; Narcotic Antagonists; Analgesia; Mice, Inbred Strains

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Hain, H. S. (1999). Quantitative trait loci mapping analysis for baseline nociceptive sensitivity and morphine-induced antinociception on the writhing assay. (Doctoral Dissertation). Oregon Health Sciences University. Retrieved from doi:10.6083/M4HX1B09 ; http://digitalcommons.ohsu.edu/etd/3356

Chicago Manual of Style (16th Edition):

Hain, Heather S. “Quantitative trait loci mapping analysis for baseline nociceptive sensitivity and morphine-induced antinociception on the writhing assay.” 1999. Doctoral Dissertation, Oregon Health Sciences University. Accessed February 26, 2020. doi:10.6083/M4HX1B09 ; http://digitalcommons.ohsu.edu/etd/3356.

MLA Handbook (7th Edition):

Hain, Heather S. “Quantitative trait loci mapping analysis for baseline nociceptive sensitivity and morphine-induced antinociception on the writhing assay.” 1999. Web. 26 Feb 2020.

Vancouver:

Hain HS. Quantitative trait loci mapping analysis for baseline nociceptive sensitivity and morphine-induced antinociception on the writhing assay. [Internet] [Doctoral dissertation]. Oregon Health Sciences University; 1999. [cited 2020 Feb 26]. Available from: doi:10.6083/M4HX1B09 ; http://digitalcommons.ohsu.edu/etd/3356.

Council of Science Editors:

Hain HS. Quantitative trait loci mapping analysis for baseline nociceptive sensitivity and morphine-induced antinociception on the writhing assay. [Doctoral Dissertation]. Oregon Health Sciences University; 1999. Available from: doi:10.6083/M4HX1B09 ; http://digitalcommons.ohsu.edu/etd/3356

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