subject:(Nanospheres)

University of Saskatchewan

1. Yasmin, Farhana 1990-. DEVELOPMENT OF ALGINATE NANOSPHERES AS A PROTEIN DELIVERY DEVICE FOR CARTILAGE TISSUE ENGINEERING.

Degree: 2018, University of Saskatchewan

URL: http://hdl.handle.net/10388/11546

► Delivery of bioactive proteins is a valuable strategy in cartilage tissue engineering (CTE) because of their ability to regulate the gene expression and extracellular matrix… (more)

▼ Delivery of bioactive proteins is a valuable strategy in cartilage tissue engineering (CTE) because of their ability to regulate the gene expression and extracellular matrix (ECM) production of engineered cartilage. This, however, has been challenged by the nature of bioactive proteins including their instability, poor tissue penetration ability, short half-life and a relatively high price. Development of nanospheres as a protein delivery device should solve these issues by promoting the temporal and spatial presentation of such bioactive proteins in a defined target for the enhanced half-life time and effectiveness. Among various polymer-based micro/nanospheres, alginate micro/nanospheres have been widely used as a protein delivery device because of their mild and easy protein encapsulation process, inert nature, non-toxicity and biocompatibility. However, one of the major limitations of using alginate as a protein delivery device is its high initial burst release due to its high porosity and instability if exposed in a higher pH release media. To address these issues, this study aimed to develop the protein loaded alginate nanospheres as a delivery device with a reduced initial burst release. The hypothesis was, “Increasing the alginate concentration, cross-linking time or drying time reduces the initial burst release independently of associated changes to the size and number of nanospheres.” Bovine Serum Albumin (BSA) was used as a model protein in this study to evaluate the performance of alginate nanospheres as a protein delivery device, while protein loaded alginate nanospheres were prepared via a combination of water-in-oil emulsification and external gelation method. The process parameters tested to reduce the initial burst release include, alginate concentration, cross-linking time and drying time. The effects of these process parameters on the nanosphere size and distribution pattern, relative number of microspheres, initial burst release, protein release kinetics and encapsulation efficiency (EE%) were investigated. Also, if the change in size and relative number of nanospheres by varying these process parameters affected the initial burst release was investigated. It has been illustrated that by properly increasing the alginate concentration, cross-linking time and drying time it was possible to reduce initial burst release by 13%, and among various process parameters only the alginate concentration showed a significant effect on the initial burst release, when considered alone. Also, it was confirmed that during determination of the effect of various process parameters the relative number of nanospheres significantly affected the initial burst release. Taken together, this study demonstrates that regulating various process parameters is a mean to reduce initial burst release of alginate nanospheres, urging more studies on alginate nanospheres for their potential application in CTE. Advisors/Committee Members: Chen, Daniel, Eames, Brian, Zhu, Ning, Boughner, Julia, Wasan, Ellen.

Subjects/Keywords: alginate nanospheres; protein delivery

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yasmin, F. 1. (2018). DEVELOPMENT OF ALGINATE NANOSPHERES AS A PROTEIN DELIVERY DEVICE FOR CARTILAGE TISSUE ENGINEERING. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/11546

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yasmin, Farhana 1990-. “DEVELOPMENT OF ALGINATE NANOSPHERES AS A PROTEIN DELIVERY DEVICE FOR CARTILAGE TISSUE ENGINEERING.” 2018. Thesis, University of Saskatchewan. Accessed January 18, 2021. http://hdl.handle.net/10388/11546.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yasmin, Farhana 1990-. “DEVELOPMENT OF ALGINATE NANOSPHERES AS A PROTEIN DELIVERY DEVICE FOR CARTILAGE TISSUE ENGINEERING.” 2018. Web. 18 Jan 2021.

Vancouver:

Yasmin F1. DEVELOPMENT OF ALGINATE NANOSPHERES AS A PROTEIN DELIVERY DEVICE FOR CARTILAGE TISSUE ENGINEERING. [Internet] [Thesis]. University of Saskatchewan; 2018. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10388/11546.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yasmin F1. DEVELOPMENT OF ALGINATE NANOSPHERES AS A PROTEIN DELIVERY DEVICE FOR CARTILAGE TISSUE ENGINEERING. [Thesis]. University of Saskatchewan; 2018. Available from: http://hdl.handle.net/10388/11546

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Zhang, Junyan. Biomedical applications of gold and silver nanoparticles.

Degree: PhD, Department of Chemical Engineering, 2018, Northeastern University

URL: http://hdl.handle.net/2047/D20290580

► Noble nanoparticles have attracted a large amount of attention among researchers due to their brilliant colors, which results from their unique optical properties from the… (more)

Subjects/Keywords: nanoparticles; gold nanospheres; drug delivery systems

10 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zhang, J. (2018). Biomedical applications of gold and silver nanoparticles. (Doctoral Dissertation). Northeastern University. Retrieved from http://hdl.handle.net/2047/D20290580

Chicago Manual of Style (16^th Edition):

Zhang, Junyan. “Biomedical applications of gold and silver nanoparticles.” 2018. Doctoral Dissertation, Northeastern University. Accessed January 18, 2021. http://hdl.handle.net/2047/D20290580.

MLA Handbook (7^th Edition):

Zhang, Junyan. “Biomedical applications of gold and silver nanoparticles.” 2018. Web. 18 Jan 2021.

Vancouver:

Zhang J. Biomedical applications of gold and silver nanoparticles. [Internet] [Doctoral dissertation]. Northeastern University; 2018. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2047/D20290580.

Council of Science Editors:

Zhang J. Biomedical applications of gold and silver nanoparticles. [Doctoral Dissertation]. Northeastern University; 2018. Available from: http://hdl.handle.net/2047/D20290580

University of Exeter

3. Gentile, Martin James. Exciton polariton modes in nanostructures.

Degree: PhD, 2016, University of Exeter

URL: http://hdl.handle.net/10871/21872

► In this thesis, original theoretical and numerical investigations into the interaction of light with excitonic nanostructures are presented, in a bid to demonstrate that excitonic… (more)

Subjects/Keywords: 620; exciton; polariton; plasmon; nanospheres; aggregates; coated

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gentile, M. J. (2016). Exciton polariton modes in nanostructures. (Doctoral Dissertation). University of Exeter. Retrieved from http://hdl.handle.net/10871/21872

Chicago Manual of Style (16^th Edition):

Gentile, Martin James. “Exciton polariton modes in nanostructures.” 2016. Doctoral Dissertation, University of Exeter. Accessed January 18, 2021. http://hdl.handle.net/10871/21872.

MLA Handbook (7^th Edition):

Gentile, Martin James. “Exciton polariton modes in nanostructures.” 2016. Web. 18 Jan 2021.

Vancouver:

Gentile MJ. Exciton polariton modes in nanostructures. [Internet] [Doctoral dissertation]. University of Exeter; 2016. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10871/21872.

Council of Science Editors:

Gentile MJ. Exciton polariton modes in nanostructures. [Doctoral Dissertation]. University of Exeter; 2016. Available from: http://hdl.handle.net/10871/21872

University of California – San Diego

4. Kim, Sejung. Novel graphene production: an aqueous arc discharge process.

Degree: Materials Sci and Engineering, 2015, University of California – San Diego

URL: http://www.escholarship.org/uc/item/9z91m920

► Graphene plays important roles in technological developments regarding electronic device, environment and energy management and the motivation to prepare two-dimensional (2D) nanomaterials. As the pioneer… (more)

▼ Graphene plays important roles in technological developments regarding electronic device, environment and energy management and the motivation to prepare two-dimensional (2D) nanomaterials. As the pioneer for 2D nanomaterials, graphene has been shown to be not only thermodynamically stable, but also superior in terms of electronic and mechanical properties and that it can be processed into a wide variety of novel materials. However, they are still limited to the challenges such as multi-stacked layers and low efficiency towards a scalable and cost-effective manufacturing process. In this dissertation, we develop an aqueous arc discharge process as a novel method to produce graphene. This novel graphene production process has the following features: (1) Low energy power consumption process to exfoliate graphene from graphite rather than to evaporate carbon molecules. (2) Water used as a dielectric medium uses a coolant to maintain the temperature during the process. (3) Controllable graphene layers and the number of oxygen-related functional groups. (4) A seamless process for morphological transition of graphene from 2D to three-dimensional (3D) construction.The graphene produced by our aqueous arc discharge is investigated as transparent electrodes and water desalination membranes. For the transparent electrodes, bi- and trilayers of graphene are adopted to be at high electrical conductance and transmittance, which are collected by vacuum-assisted filtration and then transferred to a flexible transparent polymer films. In the case of the application for water desalination, the effect of the degree of graphene oxidation is investigated and found that the affinity of 2D nanochannels to water molecules and ions affected to the flow rate and salt rejection rate due to the interfacial friction at the interface. The seamless process of the aqueous arc discharge has been achieved to crumple 2D graphene into 3D graphene nanospheres with the controllable degree of crumpling of graphene. The formation of oil-in-water emulsion during arc discharge can entrap and crumple the exfoliated graphene, simultaneously. The degree of graphene deformation can be controlled by adjusting the flow rate of oil into the plasma zone.

Subjects/Keywords: Materials Science; arc discharge; crumpled nanospheres; graphene; transparent electrode; water purification

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kim, S. (2015). Novel graphene production: an aqueous arc discharge process. (Thesis). University of California – San Diego. Retrieved from http://www.escholarship.org/uc/item/9z91m920

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kim, Sejung. “Novel graphene production: an aqueous arc discharge process.” 2015. Thesis, University of California – San Diego. Accessed January 18, 2021. http://www.escholarship.org/uc/item/9z91m920.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kim, Sejung. “Novel graphene production: an aqueous arc discharge process.” 2015. Web. 18 Jan 2021.

Vancouver:

Kim S. Novel graphene production: an aqueous arc discharge process. [Internet] [Thesis]. University of California – San Diego; 2015. [cited 2021 Jan 18]. Available from: http://www.escholarship.org/uc/item/9z91m920.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kim S. Novel graphene production: an aqueous arc discharge process. [Thesis]. University of California – San Diego; 2015. Available from: http://www.escholarship.org/uc/item/9z91m920

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

North Carolina State University

5. McGlade, John E. Directed Self Assembly of Nanospheres for NanoLithography and Nanostructured Surface Plasmon Sensors.

Degree: MS, Biomedical Engineering, 2008, North Carolina State University

URL: http://www.lib.ncsu.edu/resolver/1840.16/2758

Subjects/Keywords: Surface Plasmon; Nanospheres; Sensors

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McGlade, J. E. (2008). Directed Self Assembly of Nanospheres for NanoLithography and Nanostructured Surface Plasmon Sensors. (Thesis). North Carolina State University. Retrieved from http://www.lib.ncsu.edu/resolver/1840.16/2758

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McGlade, John E. “Directed Self Assembly of Nanospheres for NanoLithography and Nanostructured Surface Plasmon Sensors.” 2008. Thesis, North Carolina State University. Accessed January 18, 2021. http://www.lib.ncsu.edu/resolver/1840.16/2758.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McGlade, John E. “Directed Self Assembly of Nanospheres for NanoLithography and Nanostructured Surface Plasmon Sensors.” 2008. Web. 18 Jan 2021.

Vancouver:

McGlade JE. Directed Self Assembly of Nanospheres for NanoLithography and Nanostructured Surface Plasmon Sensors. [Internet] [Thesis]. North Carolina State University; 2008. [cited 2021 Jan 18]. Available from: http://www.lib.ncsu.edu/resolver/1840.16/2758.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McGlade JE. Directed Self Assembly of Nanospheres for NanoLithography and Nanostructured Surface Plasmon Sensors. [Thesis]. North Carolina State University; 2008. Available from: http://www.lib.ncsu.edu/resolver/1840.16/2758

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Tech

6. Myers, Kirby. Experiments on the Thermal, Electrical, and Plasmonic Properties of Nanostructured Materials.

Degree: PhD, Physics, 2018, Virginia Tech

URL: http://hdl.handle.net/10919/83822

► Nanofabrication techniques continue to advance and are rapidly becoming the primary route to enhancement for the electrical, thermal, and optical properties of materials. The work… (more)

▼ Nanofabrication techniques continue to advance and are rapidly becoming the primary route to enhancement for the electrical, thermal, and optical properties of materials. The work presented in this dissertation details fabrication and characterization techniques of thin films and nanoparticles for these purposes. The four primary areas of research presented here are thermoelectric enhancement through nanostructured thin films, an alternative frequency-domain thermoreflectance method for thin film thermal conductivity measurement, thermal rectification in nanodendritic porous silicon, and plasmonic enhancement in silver nanospheroids as a reverse photolithography technique. Nanostructured thermoelectrics have been proposed to greatly increase thermopower efficiency and to bring thermoelectrics to mainstream power generation and cooling applications. In our work, thermoelectric thin films of SbTe, BiTe, and PbTe grown by atomic layer deposition and electrochemical atomic layer deposition were characterized for enhanced performance over corresponding bulk materials. Seebeck coefficient measurements were performed at temperatures ranging from 77 K to 380 K. Atomic composition was verified by energy-dispersive X-ray spectroscopy and structures were imaged by scanning electron microscopy. All thin films measured were ultimately found to have a comparable or smaller Seebeck coefficient to corresponding materials made by conventional techniques, likely due to issues with the growth process. Frequency-domain thermoreflectance offers a minimally invasive optical pump-probe technique for measuring thermal conductivity. Like time-domain thermoreflectance, the version of frequency-domain thermoreflectance demonstrated here relies on a non-zero thermo-optic coefficient in the sample, but uses moderate cost continuous wave lasers modulated at kHz or MHz frequencies rather than a more expensive ultrafast laser system. The longer timescales of these frequency ranges enables this technique to take measurements of films with thicknesses ranging from 100 nm to 10 um, complimentary to time-domain thermoreflectance. This method differentiates itself from other frequency-domain methods in that it is also capable of simultaneous independent measurements of both the in plane and out of plane values of the thermal conductivity in anisotropic samples through relative reflective magnitude, rather than phase, measurements. We validated this alternate technique by measuring the thermal conductivity of Al2O3 and soda-lime and found agreement both with literature values and with separate measurements obtained with a conventional time-domain thermoreflectance setup. Thermal rectification has the potential to enhance microcircuit performance, improve thermoelectric efficiency, and enable the creation of thermal logic circuits. Passive thermal rectification has been proposed to occur in geometrically asymmetric nanostructures when heat conduction is dominated by ballistic phonons. Here, nanodendritic structures with branch widths of ~ 10 nm and… Advisors/Committee Members: Robinson, Hans D. (committeechair), Arav, Nahum (committee member), Asryan, Levon Volodya (committee member), Heflin, James R. (committee member).

Subjects/Keywords: Thermoelectrics; Thermoreflectance; Thermal Rectification; Plasmonics; Thin films; Nanospheres

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Myers, K. (2018). Experiments on the Thermal, Electrical, and Plasmonic Properties of Nanostructured Materials. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/83822

Chicago Manual of Style (16^th Edition):

Myers, Kirby. “Experiments on the Thermal, Electrical, and Plasmonic Properties of Nanostructured Materials.” 2018. Doctoral Dissertation, Virginia Tech. Accessed January 18, 2021. http://hdl.handle.net/10919/83822.

MLA Handbook (7^th Edition):

Myers, Kirby. “Experiments on the Thermal, Electrical, and Plasmonic Properties of Nanostructured Materials.” 2018. Web. 18 Jan 2021.

Vancouver:

Myers K. Experiments on the Thermal, Electrical, and Plasmonic Properties of Nanostructured Materials. [Internet] [Doctoral dissertation]. Virginia Tech; 2018. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10919/83822.

Council of Science Editors:

Myers K. Experiments on the Thermal, Electrical, and Plasmonic Properties of Nanostructured Materials. [Doctoral Dissertation]. Virginia Tech; 2018. Available from: http://hdl.handle.net/10919/83822

University of Iowa

7. Wijenayaka, A. K. Lahiru Anuradha. Improved theoretical prediction of nanoparticle stability and the synthesis, characterization, and application of gold nanopartticles of various morphology in surface-enhanced infrared spectroscopy.

Degree: PhD, Chemistry, 2015, University of Iowa

URL: https://ir.uiowa.edu/etd/1931

► The overarching objective of the investigations discussed herein is the development of a model experimental system for surface-enhanced infrared absorption (SEIRA) spectroscopy, with potential… (more)

▼ The overarching objective of the investigations discussed herein is the development of a model experimental system for surface-enhanced infrared absorption (SEIRA) spectroscopy, with potential applicability in higher order infrared spectroscopic techniques, specifically, surface-enhanced two-dimensional infrared (SE-2D IR) spectroscopy. Theoretical predictions that accurately predict the stability of functionalized nanoparticles enable guided design of their properties but are often limited by the accuracy of the parameters used as model inputs. Hence, first, such parameterization limitations for the extended DLVO (xDLVO) theory are overcome using a size-dependent Hamaker constant for gold, interfacial surface potentials, and tilt angles of self-assembled monolayers (SAMs), which collectively improves the predictive power of xDLVO theory for modeling nanoparticle stability. Measurements of electrical properties of functionalized gold nanoparticles validate the predictions of xDLVO theory using these new parameterizations illustrating the potential for this approach to improve the design and control of the properties of functionalized gold nanoparticles in various applications. Next, a series of experiments were conducted to elucidate the behavior of various infrared active molecules in the presence of spherical gold nanoparticles of average diameter ∼20 nm. Here, the spectroscopic anomalies, specifically the shifted vibrational frequency and the dispersive lineshape observed in the infrared spectra for SCN- in the presence of gold nanoparticles provide direct evidence of SIERA. Nevertheless, it was evidenced that nanomaterial with plasmonic properties that extends into the infrared wavelengths are imperative in observing efficient infrared enhancements. Hence, nanomaterial indicating plasmonic properties extending into the infrared wavelengths were synthesized via a straightforward, seedless, one-pot synthesis. The gold nanostars prepared here indicated plasmonic behavior clearly extending into the near infrared, with simple plasmonic tunability via changing the buffer concentration used during synthesis. The systematic understanding achieved here in terms of theoretical prediction of nanoparticle stability, origin of infrared spectral anomalies in the presence of nanomaterials, and the preparation of infrared plasmonic material, collectively provides a resilient framework for the further investigation of surface-enhanced infrared spectroscopic techniques including SEIRA and SE-2D IR spectroscopies. Advisors/Committee Members: Cheatum, Christopher M. (supervisor).

Subjects/Keywords: publicabstract; Nanospheres; Nanostars; SE-2D IR; SEIRA; Surface enhancement; xDLVO; Chemistry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wijenayaka, A. K. L. A. (2015). Improved theoretical prediction of nanoparticle stability and the synthesis, characterization, and application of gold nanopartticles of various morphology in surface-enhanced infrared spectroscopy. (Doctoral Dissertation). University of Iowa. Retrieved from https://ir.uiowa.edu/etd/1931

Chicago Manual of Style (16^th Edition):

Wijenayaka, A K Lahiru Anuradha. “Improved theoretical prediction of nanoparticle stability and the synthesis, characterization, and application of gold nanopartticles of various morphology in surface-enhanced infrared spectroscopy.” 2015. Doctoral Dissertation, University of Iowa. Accessed January 18, 2021. https://ir.uiowa.edu/etd/1931.

MLA Handbook (7^th Edition):

Wijenayaka, A K Lahiru Anuradha. “Improved theoretical prediction of nanoparticle stability and the synthesis, characterization, and application of gold nanopartticles of various morphology in surface-enhanced infrared spectroscopy.” 2015. Web. 18 Jan 2021.

Vancouver:

Wijenayaka AKLA. Improved theoretical prediction of nanoparticle stability and the synthesis, characterization, and application of gold nanopartticles of various morphology in surface-enhanced infrared spectroscopy. [Internet] [Doctoral dissertation]. University of Iowa; 2015. [cited 2021 Jan 18]. Available from: https://ir.uiowa.edu/etd/1931.

Council of Science Editors:

Wijenayaka AKLA. Improved theoretical prediction of nanoparticle stability and the synthesis, characterization, and application of gold nanopartticles of various morphology in surface-enhanced infrared spectroscopy. [Doctoral Dissertation]. University of Iowa; 2015. Available from: https://ir.uiowa.edu/etd/1931

8. Charest, Abigail J. Investigation of Physical Characteristics Impacting Fate and Transport of Viral Surrogates in Water Systems.

Degree: PhD, 2015, Worcester Polytechnic Institute

URL: etd-012915-130553 ; https://digitalcommons.wpi.edu/etd-dissertations/54

► A multi-scale approach was used to investigate the occurrence and physical characteristics of viral surrogates in water systems. This approach resulted in a methodology to… (more)

▼ A multi-scale approach was used to investigate the occurrence and physical characteristics of viral surrogates in water systems. This approach resulted in a methodology to quantify the dynamics and physical parameters of viral surrogates, including bacteriophages and nanoparticles. Physical parameters impacting the occurrence and survival of viruses can be incorporated into models that predict the levels of viral contamination in specific types of water. Multiple full-scale water systems (U.S., Italy and Australia) were tested including surface water, drinking water, stormwater and wastewater systems. Water quality parameters assessed included viral markers (TTV, polyomavirus, microviridae and adenovirus), bacteriophages (MS2 and ΦX-174), and coliforms (total coliforms and E. coli). In this study, the lack of correlations between adenovirus and that of bacterial indicators suggests that these bacterial indicators are not suitable as indicators of viral contamination. In the wastewater samples, microviridae were correlated to the adenovirus, polyomavirus, and TTV. While TTV may have some qualities which are consistent with an indicator such as physical similarity to enteric viruses and occurrence in populations worldwide, the use of TTV as an indicator may be limited as a result of the detection occurrence. The limitations of TTV may impede further analysis and other makers such as coliphages, and microviridae may be easier to study in the near future. Batch scale adsorption tests were conducted. Protein-coated latex nanospheres were used to model bacteriophages (MS2 and ΦX-174) and includes a comparison of the zeta potentials in lab water, and two artificial groundwaters with monovalent and divalent electrolytes. This research shows that protein-coated particles have higher average log10 removals than uncoated particles. Although, the method of fluorescently labeling nanoparticles may not provide consistent data at the nanoscale. The results show both that research on viruses at any scale can be difficult and that new methodologies are needed to analyze virus characteristics in water systems. A new dynamic light scattering methodology, area recorded generalized optical scattering (ARGOS) method, was developed for observing the dynamics of nanoparticles, including bacteriophages MS2 and ΦX-174. This method should be further utilized to predict virus fate and transport in environmental systems and through treatment processes. While the concentration of MS2 is higher than ΦX-174 as demonstrated by relative total intensity, the RMSD shows that the dynamics are greater and have more variation in ΦX-174 than MS2 and this may be a result of the hydrophobic nature of ΦX-174. Relationships such as these should be further explored, and may reflect relationships such as particle bonds or hydrophobicity. Advisors/Committee Members: David S. Adams, Committee Member, Germano S. Iannacchione, Committee Member, Sharon C. Long, Committee Member, John A. Bergendahl, Committee Member, Jeanine D. Plummer, Advisor.

Subjects/Keywords: Time-Dependent Light Scattering; Nanospheres; Bacteriophages; ARGOS method

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Charest, A. J. (2015). Investigation of Physical Characteristics Impacting Fate and Transport of Viral Surrogates in Water Systems. (Doctoral Dissertation). Worcester Polytechnic Institute. Retrieved from etd-012915-130553 ; https://digitalcommons.wpi.edu/etd-dissertations/54

Chicago Manual of Style (16^th Edition):

Charest, Abigail J. “Investigation of Physical Characteristics Impacting Fate and Transport of Viral Surrogates in Water Systems.” 2015. Doctoral Dissertation, Worcester Polytechnic Institute. Accessed January 18, 2021. etd-012915-130553 ; https://digitalcommons.wpi.edu/etd-dissertations/54.

MLA Handbook (7^th Edition):

Charest, Abigail J. “Investigation of Physical Characteristics Impacting Fate and Transport of Viral Surrogates in Water Systems.” 2015. Web. 18 Jan 2021.

Vancouver:

Charest AJ. Investigation of Physical Characteristics Impacting Fate and Transport of Viral Surrogates in Water Systems. [Internet] [Doctoral dissertation]. Worcester Polytechnic Institute; 2015. [cited 2021 Jan 18]. Available from: etd-012915-130553 ; https://digitalcommons.wpi.edu/etd-dissertations/54.

Council of Science Editors:

Charest AJ. Investigation of Physical Characteristics Impacting Fate and Transport of Viral Surrogates in Water Systems. [Doctoral Dissertation]. Worcester Polytechnic Institute; 2015. Available from: etd-012915-130553 ; https://digitalcommons.wpi.edu/etd-dissertations/54

Virginia Tech

9. Abtahi, Seyyed Mohammad Hossein. Synthesis and characterization of metallic nanoparticles with photoactivated surface chemistries.

Degree: MS, Chemical Engineering, 2013, Virginia Tech

URL: http://hdl.handle.net/10919/78081

► During recent decades metallic nanoparticles have been found very interesting due to their unique characteristics which make them suitable for different applications. In this research,… (more)

Subjects/Keywords: surface plasmon resonance; PEG (poly ethylene glycol); UV photo activation; photocleavable oligomer; silver nanospheres centrifugal separation; Metallic nanoparticles; gold nanorods; gold nanospheres; UV-Vis absorbance; TEM (transmission electron microscopy)

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Abtahi, S. M. H. (2013). Synthesis and characterization of metallic nanoparticles with photoactivated surface chemistries. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/78081

Chicago Manual of Style (16^th Edition):

Abtahi, Seyyed Mohammad Hossein. “Synthesis and characterization of metallic nanoparticles with photoactivated surface chemistries.” 2013. Masters Thesis, Virginia Tech. Accessed January 18, 2021. http://hdl.handle.net/10919/78081.

MLA Handbook (7^th Edition):

Abtahi, Seyyed Mohammad Hossein. “Synthesis and characterization of metallic nanoparticles with photoactivated surface chemistries.” 2013. Web. 18 Jan 2021.

Vancouver:

Abtahi SMH. Synthesis and characterization of metallic nanoparticles with photoactivated surface chemistries. [Internet] [Masters thesis]. Virginia Tech; 2013. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10919/78081.

Council of Science Editors:

Abtahi SMH. Synthesis and characterization of metallic nanoparticles with photoactivated surface chemistries. [Masters Thesis]. Virginia Tech; 2013. Available from: http://hdl.handle.net/10919/78081

University of Cincinnati

10. Alazemi, Mubarak FMF. Controlled Assembly of Graphene Sheets and Carbon Nanospheres for Optimum Electrical Conductivity in Nanostructured Coatings.

Degree: PhD, Engineering : Chemical Engineering, 2010, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1275078196

► Layer-by-layer assembly (LbL) is emerging as a key nano manufacturing technique that is finding a broad range of applications. It is a versatile and simple,… (more)

▼ Layer-by-layer assembly (LbL) is emerging as a key nano manufacturing technique that is finding a broad range of applications. It is a versatile and simple, allowing the realization of novel nanometer-scale multi-layered materials and structures that can be made to have highly desirable properties. Despite such long-standing use, LbL assembly of carbon nanoparticles for conductive coating applications has rarely been explored. In this work, three-dimensional nanostructure evolution and adsorption kinetics during carbon nanoparticle LbL assembly are investigated for thin film coating applications that require high through-plane electrical conductivity. Two types of nanoparticles are evaluated: 5-10 nm thick stacks of graphene sheets and 20 nm diameter amorphous carbon spheres. Electrostatic interactions between the carbon nanoparticles and a cationic polyacrylamide binder are systematically altered by varying the carbon nanoparticle suspending media composition according to the Gouy Chapman Theory. Electrostatic interactions are quantified with zeta potential measurements. Suspension pH is used to control the nanoparticle surface charge density through dissociation of hydrolyzed surface groups while the addition of alcohol is used to enhance electrostatic interactions by altering the dielectric constant of the medium. Alcohol and pH are found to have opposing effects with respect to the packing density and through-plane conductivity of the structures formed for both types of nanoparticles. Such behavior is ascribed to steric effects associated with the heterogeneous dispersion of weakly acidic functional groups on the hydrolyzed carbon nanoparticle surface. Complete dissociation of these groups in the absence of alcohol yields densely packed structures with as much as 40 percent reduction in through-plane conductivity relative to coatings with a greater degree of carbon nanoparticle aggregation and more porous structures. The more densely packed structures involve fewer direct interactions and instead more carbon interactions with the electrically insulating polyelectrolyte binder, yielding the more rapid substrate surface saturation and the higher contact resistance observed. This work was able to establish the LbL process conditions under which carbon coatings sufficiently conductive for a broad range of applications could be produced: from ESD applications to fuel cell biplar plate.Carbon nanoplatelet adsorption kinetics was modeled using the Michaelis-Menten (M-M) mechanism, where long-range interaction of the surface with the nanoparticles was hypothesized to yield a reversibly bound species that, with sufficiently strong substrate-adsorbate attraction could become irreversibly bound and thereby incorporated into the LbL assembled structure. Linear irreversible carbon nanoplatelet uptake versus time was observed when electrostatic attraction between the substrate and adsorbate was minimal, consistent with the M-M prediction when irreversible adsorption is rate-limiting due to generally weak substrate-adsorbate… Advisors/Committee Members: Angelopoulos, Anastasios (Committee Chair).

Subjects/Keywords: Chemical Engineering; LbL; Carbon Nanospheres; nanoparticles; Nanospheres; Carbon; Graphite; Coatings

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Alazemi, M. F. (2010). Controlled Assembly of Graphene Sheets and Carbon Nanospheres for Optimum Electrical Conductivity in Nanostructured Coatings. (Doctoral Dissertation). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1275078196

Chicago Manual of Style (16^th Edition):

Alazemi, Mubarak FMF. “Controlled Assembly of Graphene Sheets and Carbon Nanospheres for Optimum Electrical Conductivity in Nanostructured Coatings.” 2010. Doctoral Dissertation, University of Cincinnati. Accessed January 18, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1275078196.

MLA Handbook (7^th Edition):

Alazemi, Mubarak FMF. “Controlled Assembly of Graphene Sheets and Carbon Nanospheres for Optimum Electrical Conductivity in Nanostructured Coatings.” 2010. Web. 18 Jan 2021.

Vancouver:

Alazemi MF. Controlled Assembly of Graphene Sheets and Carbon Nanospheres for Optimum Electrical Conductivity in Nanostructured Coatings. [Internet] [Doctoral dissertation]. University of Cincinnati; 2010. [cited 2021 Jan 18]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1275078196.

Council of Science Editors:

Alazemi MF. Controlled Assembly of Graphene Sheets and Carbon Nanospheres for Optimum Electrical Conductivity in Nanostructured Coatings. [Doctoral Dissertation]. University of Cincinnati; 2010. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1275078196

Universidade Estadual de Campinas

11. Azevedo, Marcelo Mantovani Martiniano. Sistemas polimericos de liberação controlada utilizando micro e nanoparticulas encapsulando violaceina : caracterização, atividade biologica, consequencias e perpectivas: Polymeric drug delivery systems using micro and nanospheres containing violacein: characterization, biological activity, consenquences and perspectives.

Degree: 2005, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/248887

► Abstract: In this work we investigate polymeric systems transporting violacein, substance of pharmacological interest, more specifically antitumoral, obtained from the biosynthesis of Chromobacterium violaceum. However,… (more)

Subjects/Keywords: Nanoesferas; Violaceina; Câncer; Nanospheres; Violacein; Apoptosis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Azevedo, M. M. M. (2005). Sistemas polimericos de liberação controlada utilizando micro e nanoparticulas encapsulando violaceina : caracterização, atividade biologica, consequencias e perpectivas: Polymeric drug delivery systems using micro and nanospheres containing violacein: characterization, biological activity, consenquences and perspectives. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/248887

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Azevedo, Marcelo Mantovani Martiniano. “Sistemas polimericos de liberação controlada utilizando micro e nanoparticulas encapsulando violaceina : caracterização, atividade biologica, consequencias e perpectivas: Polymeric drug delivery systems using micro and nanospheres containing violacein: characterization, biological activity, consenquences and perspectives.” 2005. Thesis, Universidade Estadual de Campinas. Accessed January 18, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248887.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Azevedo, Marcelo Mantovani Martiniano. “Sistemas polimericos de liberação controlada utilizando micro e nanoparticulas encapsulando violaceina : caracterização, atividade biologica, consequencias e perpectivas: Polymeric drug delivery systems using micro and nanospheres containing violacein: characterization, biological activity, consenquences and perspectives.” 2005. Web. 18 Jan 2021.

Vancouver:

Azevedo MMM. Sistemas polimericos de liberação controlada utilizando micro e nanoparticulas encapsulando violaceina : caracterização, atividade biologica, consequencias e perpectivas: Polymeric drug delivery systems using micro and nanospheres containing violacein: characterization, biological activity, consenquences and perspectives. [Internet] [Thesis]. Universidade Estadual de Campinas; 2005. [cited 2021 Jan 18]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/248887.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Azevedo MMM. Sistemas polimericos de liberação controlada utilizando micro e nanoparticulas encapsulando violaceina : caracterização, atividade biologica, consequencias e perpectivas: Polymeric drug delivery systems using micro and nanospheres containing violacein: characterization, biological activity, consenquences and perspectives. [Thesis]. Universidade Estadual de Campinas; 2005. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/248887

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Santa Cruz

12. Lindley, Sarah Anne. Investigations of Structure-Dependent Photophysical Properties of Metal, Metal Oxide, and Semiconductor Nanostructures.

Degree: Chemistry, 2018, University of California – Santa Cruz

URL: http://www.escholarship.org/uc/item/5005r1ch

► On the nanoscale, size and structure are powerful dictators of optical and electronic response. As such, they may be rationally manipulated in order to obtain… (more)

▼ On the nanoscale, size and structure are powerful dictators of optical and electronic response. As such, they may be rationally manipulated in order to obtain desired properties for specific applications. The dissertation projects herein are aimed toward understanding how structure affects the photophysical properties of three nanoparticle systems: hollow gold nanospheres (HGNs), doped α-Fe2O3 nanostructures, and PbS/CdS core/shell quantum dots (QDs). The dissertation is divided into two parts: Part I: The Highly Tunable Hollow Gold Nanosphere: Synthesis, Size, and Surface Morphology and Part II: Ultrafast Charge Carrier Dynamics of Hematite Nanostructures and PbS/CdS Quantum DotsPart I focuses on synthetic control and characterization of HGNs, solvent-filled plasmonic shells of gold ranging from 20-200 nm in diameter. HGNs have shown promising performance in drug loading, targeted delivery, surface-enhanced Raman scattering, and photothermal therapy. Their optical properties are very sensitive to their aspect ratio, the ratio of diameter to shell thickness. As such, a well-controlled synthesis is highly desired. In Chapter 1, the HGN synthesis was updated to enable simultaneous control of both diameter and SPR while maintaining monodispersity and uniformity of the resultant shells. This was possible through a detailed and systematic investigation of the synthesis of the sacrificial cobalt-based scaffolds onto which HGNs are formed through galvanic exchange.In Chapter 2, additional synthetic adjustments were introduced to systematically control the HGN surface morphology from smooth to very bumpy. Rugose structures are perhaps the most versatile nanoparticles, with an increased density of active sites for catalysis as well as local electric field enhancement around the surface features for sensing and detection. As hollow particles have displayed enhanced plasmonic performance in comparison with their solid counterparts for a number of applications, the combination of hollow cores and rugose surfaces is highly attractive. One of the most attractive applications of HGNs is plasmonic photothermal therapy (PTT). In this application, plasmonic nanoparticles are targeted to cancer cells where they convert incident light to heat, raising the temperature of their environment above the point of cell viability. A systematic comparison of HGNs with different surface morphologies revealed that bumpy HGNs retain the excellent photothermal conversion efficiency (PCE) of their smooth counterparts. Next, in Chapter 3, PCE was investigated for HGNs of different diameters, theoretically and experimentally. The findings revealed that 50 nm HGNs generate ~2 times the heat per µg gold as their 70 nm counterparts and ~1.5 times the heat per µg gold as their 30 nm counterparts. In vitro HGN-mediated PTT of oral squamous cell carcinoma was also carried out. Ongoing efforts are needed to assess the PCE and potential size dependence of HGNs in vitro and in vivo.In Part II, transient absorption spectroscopy (TAS) is used to probe the charge…

Subjects/Keywords: Physical chemistry; Nanoscience; Nanotechnology; Hollow Gold Nanospheres; Photothermal Therapy; Surface Plasmon Resonance

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lindley, S. A. (2018). Investigations of Structure-Dependent Photophysical Properties of Metal, Metal Oxide, and Semiconductor Nanostructures. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/5005r1ch

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lindley, Sarah Anne. “Investigations of Structure-Dependent Photophysical Properties of Metal, Metal Oxide, and Semiconductor Nanostructures.” 2018. Thesis, University of California – Santa Cruz. Accessed January 18, 2021. http://www.escholarship.org/uc/item/5005r1ch.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lindley, Sarah Anne. “Investigations of Structure-Dependent Photophysical Properties of Metal, Metal Oxide, and Semiconductor Nanostructures.” 2018. Web. 18 Jan 2021.

Vancouver:

Lindley SA. Investigations of Structure-Dependent Photophysical Properties of Metal, Metal Oxide, and Semiconductor Nanostructures. [Internet] [Thesis]. University of California – Santa Cruz; 2018. [cited 2021 Jan 18]. Available from: http://www.escholarship.org/uc/item/5005r1ch.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lindley SA. Investigations of Structure-Dependent Photophysical Properties of Metal, Metal Oxide, and Semiconductor Nanostructures. [Thesis]. University of California – Santa Cruz; 2018. Available from: http://www.escholarship.org/uc/item/5005r1ch

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Akron

13. Ditto, Andrew J. DNA-LPEI complexes encapsulated in LTP nanospheres as a non-viral gene therapy vector.

Degree: MSin Engineering, Biomedical Engineering, 2006, University of Akron

URL: http://rave.ohiolink.edu/etdc/view?acc_num=akron1165596983

► Viruses are uniquely equipped to insert their genome into cells, which is due partly to their ability to transport across cellular membranes and to escape… (more)

Subjects/Keywords: Engineering, Biomedical; nanospheres; gene therapy; non-viral vectors; gene vectors; sustained release; DNA loaded nanospheres; endocytosed nanospheres; DNA-LPEI

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ditto, A. J. (2006). DNA-LPEI complexes encapsulated in LTP nanospheres as a non-viral gene therapy vector. (Masters Thesis). University of Akron. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=akron1165596983

Chicago Manual of Style (16^th Edition):

Ditto, Andrew J. “DNA-LPEI complexes encapsulated in LTP nanospheres as a non-viral gene therapy vector.” 2006. Masters Thesis, University of Akron. Accessed January 18, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1165596983.

MLA Handbook (7^th Edition):

Ditto, Andrew J. “DNA-LPEI complexes encapsulated in LTP nanospheres as a non-viral gene therapy vector.” 2006. Web. 18 Jan 2021.

Vancouver:

Ditto AJ. DNA-LPEI complexes encapsulated in LTP nanospheres as a non-viral gene therapy vector. [Internet] [Masters thesis]. University of Akron; 2006. [cited 2021 Jan 18]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=akron1165596983.

Council of Science Editors:

Ditto AJ. DNA-LPEI complexes encapsulated in LTP nanospheres as a non-viral gene therapy vector. [Masters Thesis]. University of Akron; 2006. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=akron1165596983

Universidade do Rio Grande do Sul

14. Klein, Alana Carina. Estudo da influência do solvente orgânico e do fluxo de injeção no controle de tamanho de nanocápsulas de núcleo lipídico preparadas através do método de deslocamento de solvente.

Degree: 2013, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/143554

►

O fluxo de injeção e o solvente orgânico, utilizado no preparo de nanoesferas poliméricas, são parâmetros experimentais que controlam o diâmetro e a distribuição de… (more)

▼

O fluxo de injeção e o solvente orgânico, utilizado no preparo de nanoesferas poliméricas, são parâmetros experimentais que controlam o diâmetro e a distribuição de diâmetro das nanopartículas, formadas pelo processo conhecido como nucleação. Considerando as nanocápsulas de núcleo lipídico, formadas pelo processo de auto-organização, estes parâmetros experimentais ainda não foram explorados. Assim, esse trabalho propõe avaliar o fluxo de injeção e o solvente orgânico na preparação destas suspensões aquosas, caracterizando físicoquimicamente estes sistemas. Para variação de fluxo de injeção, utilizou-se uma bomba peristáltica, sendo possível a avaliação dos seguintes fluxos: 5, 8, 12, 15, 21 e 38 mL min¯¹. O diâmetro das nanocápsulas diminuiu de 256±9 nm a 127 ±8 nm pela técnica de difração de laser e 220±9 nm a 124±13 nm, segundo a técnica de espectroscopia de correlação de fótons. Os solventes orgânicos avaliados foram a acetona, acetonitrila e 1,4-Dioxano. Observou-se que a acetonitrila se mostrou adequada para a condição previamente otimizada com acetona, ao passo que o 1,4-Dioxano apresentou um pico micrométrico em sua distribuição. Assim, foi possível modelar este estudo através de um fatorial de design 2², onde têm-se dois fatores, fluxo de injeção e solvente orgânico, em dois níveis, nos fluxos de 5 e 38 mL min¯¹ e considerando os solventes acetona e acetonitrila. Como resultado, viu-se que o fluxo de injeção é o parâmetro de maior influência na preparação destas suspensões aquosas, se comparado ao solvente orgânico selecionado. Para elucidar o papel do solvente orgânico na preparação destes sistemas, calculouse os parâmetros de solubilidade e os coeficientes de difusão solvente orgânico\água e água\solvente orgânico para os três pares avaliados neste trabalho. Viu-se que os parâmetros de solubilidade e os coeficientes de difusão solvente orgânico\água explicam a não variação do diâmetro de partícula em função do solvente orgânico. Ainda, realizou-se um estudo de viscosidade, em função do log [PCL], para fases orgânicas preparadas com acetonitrila e 1,4- dioxano. Obteve-se o valor de 2,30 mg mL¯¹ para a concentração de agregação crítica quando utilizado o 1,4-Dioxano e 10,47 mg mL¯¹ para a fase orgânica preparada com acetonitrila. Então, pode-se dizer que este valor elevado encontrado para a acetonitrila é uma vantagem de sua utilização, uma vez que as características nanoscópicas são mantidas e um maior número de partículas pode ser formado.

Flow rate and organic solvent, used to prepare polimeric nanospheres, are experimental parameters that control the size and the size distribution curves of these nanoparticles, formed by particle nucleation. Considering the lipid core nanocapsules, formed by self-assembled process, these experimental parameters are not evaluated yet. Considering those, this work proposes to evaluate the flow rate and the organic solvent in the preparation of these aqueous suspensions, characterizing them physicochemically. To change the flow rate, it was used a peristaltic pump, it…

Advisors/Committee Members: Pohlmann, Adriana Raffin.

Subjects/Keywords: Nanocapsulas; Nanospheres; Critical aggregation concentration; Solvente orgânico; Nanoesferas; Factorial study; Nanoparticle size; Organic solvent; Flow rate; Nanocapsules

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Klein, A. C. (2013). Estudo da influência do solvente orgânico e do fluxo de injeção no controle de tamanho de nanocápsulas de núcleo lipídico preparadas através do método de deslocamento de solvente. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/143554

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Klein, Alana Carina. “Estudo da influência do solvente orgânico e do fluxo de injeção no controle de tamanho de nanocápsulas de núcleo lipídico preparadas através do método de deslocamento de solvente.” 2013. Thesis, Universidade do Rio Grande do Sul. Accessed January 18, 2021. http://hdl.handle.net/10183/143554.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Klein, Alana Carina. “Estudo da influência do solvente orgânico e do fluxo de injeção no controle de tamanho de nanocápsulas de núcleo lipídico preparadas através do método de deslocamento de solvente.” 2013. Web. 18 Jan 2021.

Vancouver:

Klein AC. Estudo da influência do solvente orgânico e do fluxo de injeção no controle de tamanho de nanocápsulas de núcleo lipídico preparadas através do método de deslocamento de solvente. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2013. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10183/143554.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Klein AC. Estudo da influência do solvente orgânico e do fluxo de injeção no controle de tamanho de nanocápsulas de núcleo lipídico preparadas através do método de deslocamento de solvente. [Thesis]. Universidade do Rio Grande do Sul; 2013. Available from: http://hdl.handle.net/10183/143554

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Ταπεινός, Χρήστος. Σύνθεση και χαρακτηρισμός νανοσφαιρών οξειδίων σιδήρου : μελέτη μαγνητικών ιδιοτήτων αιματίτη και μαγγεμίτη.

Degree: 2009, University of Patras

URL: http://nemertes.lis.upatras.gr/jspui/handle/10889/4137

►

Πολλοί από τους τομείς της επιστημονικής έρευνας, όπως χημεία, ενέργεια, βιομηχανία και ιατρική χρησιμοποιούν τη νανοτεχνολογία, με στόχο την παρασκευή υλικών, με καλύτερες και πιο… (more)

▼

Πολλοί από τους τομείς της επιστημονικής έρευνας, όπως χημεία, ενέργεια, βιομηχανία και ιατρική χρησιμοποιούν τη νανοτεχνολογία, με στόχο την παρασκευή υλικών, με καλύτερες και πιο εξειδικευμένες ιδιότητες σε σχέση με τα συμβατικά υλικά του μακρόκοσμου. Οι νανοσφαίρες λόγω των ποικίλων ιδιοτήτων που παρουσιάζουν, όπως οπτικές, μηχανικές, ηλεκτρικές κ.α., μπορούν να χρησιμοποιηθούν σε διάφορους τομείς της καθημερινής μας ζωής με μεγαλύτερο ενδιαφέρον στον τομέα της υγείας. Η παρούσα ερευνητική εργασία πραγματοποιήθηκε με στόχο τη σύνθεση και τη μελέτη νανοσφαιρών οξειδίων του σιδήρου. Πιο συγκεκριμένα παρασκευάσθηκαν νανοσφαίρες αιματίτη (α – Fe2O3) και μαγγεμίτη (γ – Fe2O3) και μελετήθηκαν οι μαγνητικές τους ιδιότητες. Στο πρώτο κεφάλαιο παρουσιάζεται μία εισαγωγή – ιστορική αναδρομή στο χώρο της νανοτεχνολογίας και των νανοσφαιρών. Γίνεται επίσης αναφορά στους τρόπους σύνθεσης των νανοσφαιρών και αναφέρονται εν συντομία κάποιες ιδιότητες και εφαρμογές αυτών. Στο δεύτερο κεφάλαιο αναφέρονται κάποιες βασικές έννοιες οι οποίες είναι απαραίτητες για την κατανόηση των ταχνικών που θα χρησιμοποιηθούν. Παρουσιάζονται αναλυτικά οι τρόποι με τους οποίους πραγματοποιείται η σύνθεση των νανοσφαιρών και περιγράφονται αναλυτικά, η μέθοδος λύματος – πηκτής (sol – gel) και η τεχνική του πολυμερισμού. Στο τρίτο κεφάλαιο αναφέρονται τα αντιδραστήρια καθώς επίσης και οι πειραματικές μέθοδοι που χρησιμοποιήθηκαν για το χαρακτηρισμό των νανοσφαιρών και τη μελέτη των ιδιοτήτων τους. Αναφέρονται επίσης τα όργανα που χρησιμοποιήθηκαν καθώς επίσης και οι βασικές αρχές λειτουργίας αυτών. Στο τέταρτο κεφάλαιο περιγράφεται αναλυτικά η πειραματική διαδικασία που πραγματοποιήθηκε και γίνεται συζήτηση των αποτελεσμάτων. Τέλος στο πέμπτο κεφάλαιο ανγράφονται τα συμπεράσματα και αναφέρονται μελλοντικοί στόχοι.

Nanotechnology is the study of the control of matter on an atomic and molecular scale and it’s main objective is the manufacture of new materials with better and more sophisticated properties. Nanotechnology is used in many different sciences like chemistry, physics and most of all in medicine. Nanospheres exhibit many diverse properties (electrical, optical etc) which render them the best solution for application such as drug delivery systems, Magnetic Resonance Imaging (MRI) agents, hyperthermia etc. The present work deals with the synthesis and characterization of magnetic nanospheres and more specifically in the study of magnetic properties of hematite (α – Fe2O3) and maghemite (γ – Fe2O3). The first chapter starts with a short introduction for nanospheres and nanotechnology . It reports also a quick historical review and some lines about new generation nanospheres, it’s properties and it’s applications. In the second chapter, polymerization and sol – gel techniques are described analytically. In the third chapter, reactants and experimental methods are described as well as some basic principles of the methods that were used to characterize the samples. The fourth chapter is the results and discussion session. …

Advisors/Committee Members: Κόρδας, Γεώργιος, Tapeinos, Christos, Κόρδας, Γεώργιος, Πουλόπουλος, Παναγιώτης, Μπουρόπουλος, Νικόλαος.

Subjects/Keywords: Μαγγεμίτης; γ-Fe2O3; Οξείδια; Σίδηρος; Μαγνητικές ιδιότητες; Νανόσφαιρες; Αιματίτης; α-Fe2O3; 546.621 2; Maghemite; Oxides; Iron; Magnetic properties; Hematite; Nanospheres

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ταπεινός, �. (2009). Σύνθεση και χαρακτηρισμός νανοσφαιρών οξειδίων σιδήρου : μελέτη μαγνητικών ιδιοτήτων αιματίτη και μαγγεμίτη. (Masters Thesis). University of Patras. Retrieved from http://nemertes.lis.upatras.gr/jspui/handle/10889/4137

Chicago Manual of Style (16^th Edition):

Ταπεινός, Χρήστος. “Σύνθεση και χαρακτηρισμός νανοσφαιρών οξειδίων σιδήρου : μελέτη μαγνητικών ιδιοτήτων αιματίτη και μαγγεμίτη.” 2009. Masters Thesis, University of Patras. Accessed January 18, 2021. http://nemertes.lis.upatras.gr/jspui/handle/10889/4137.

MLA Handbook (7^th Edition):

Ταπεινός, Χρήστος. “Σύνθεση και χαρακτηρισμός νανοσφαιρών οξειδίων σιδήρου : μελέτη μαγνητικών ιδιοτήτων αιματίτη και μαγγεμίτη.” 2009. Web. 18 Jan 2021.

Vancouver:

Ταπεινός �. Σύνθεση και χαρακτηρισμός νανοσφαιρών οξειδίων σιδήρου : μελέτη μαγνητικών ιδιοτήτων αιματίτη και μαγγεμίτη. [Internet] [Masters thesis]. University of Patras; 2009. [cited 2021 Jan 18]. Available from: http://nemertes.lis.upatras.gr/jspui/handle/10889/4137.

Council of Science Editors:

Ταπεινός �. Σύνθεση και χαρακτηρισμός νανοσφαιρών οξειδίων σιδήρου : μελέτη μαγνητικών ιδιοτήτων αιματίτη και μαγγεμίτη. [Masters Thesis]. University of Patras; 2009. Available from: http://nemertes.lis.upatras.gr/jspui/handle/10889/4137

16. Angelopoulou, Athina. Μελέτη υλικών βιολογικού ενδιαφέροντος μέσω προηγμένων φασματοσκοπικών τεχνικών.

Degree: 2013, University of Patras; Πανεπιστήμιο Πατρών

URL: http://hdl.handle.net/10442/hedi/31772

► Recently the study of biomaterials has moved in two directions, the evolution of drug deliverysystems and of systems that can stimulate specific cellular responses. Our… (more)

▼ Recently the study of biomaterials has moved in two directions, the evolution of drug deliverysystems and of systems that can stimulate specific cellular responses. Our investigation aims tothe study of drug delivery systems for bone cancer therapy. These systems must fulfill twoimportant functionalities. At first, they should be able to deliver drug molecules to bone cancerenvironment through loading or surface conjugation and subsequently to cause osteogenesis.Their second functionality is especially important since it leads to substitution of bone defectscaused from the action of cancer cells. Bioactive glasses are of great advantage because of theirability to form hydroxyapatite and to bond to bone tissue after implantation. However,compared to bioglasses, bioactive nanospheres offer quite interesting advantages due to theirenhanced properties in drug delivery and their ability to seal bone defects of irregulargeometry.For this purpose in the present thesis characteristic bioactive glassy structures are studied inorder to investigate their conversion to nanoscale structures for further application in drugdelivery as target agents in bone cancer. Of great importance is the investigation of the role ofphosphorus in osteogenesis. Therefore, the ex vitro study of local phosphorous environment in45S5 bioglasses is studied through 31P MAS NMR and 1H-31P CP MAS NMR experiments.The nearly identical NMR spectra obtained by cross-polarization verified that the 31Penvironments and its SBF induced surface layers consist of water molecules and OH groupswhich are probably primarily associated with the a-CaP surface layer and secondly with theCaP components of the bioglasses. Moreover, the confirmed presence of a-CaP surface layerwas observed through the full width at half-maximum height which is significantly broaderthan that presented by nano-crystalline HCA and is typical for an amorphous orthophosphatephase. The obtained information proved the important contribution of the phosphorousenvironment from the first stage of apatite formation, the presence of which results inenhanced contribution to HCA formation and subsequent osteogenesis.Furthermore, the ability of the glassy network to deliver drug molecules was studied. For thispurpose, expanded ex vitro research was followed in DOX conjugated pH-sensitivefunctionalized silica xerogels. Specifically, silica xerogels were synthesized through a sol-gelprocess and further functionalized with carbodiimide chemistry. The functionalization processresulted in pH-sensitive dextran hydrogels. The anticancer drug DOX was bounded on thefunctionalized xerogel by a second stage of EDC coupling. Moreover the bioactivities of thefunctionalized xerogels in connection to release studies in acidic and neutral pH were alsofollowed. According to the SBF study, flake-like apatite formations were observed after 7 daysof treatment. The release of the DOX through an acidic treatment can possibly be attributed toan acidic sensitive esteric bond formation. Consequently, the above organically modified…

Subjects/Keywords: Βιοενεργές νανοσφαίρες; Υδρογέλες δεξτράνης; Δοξορουμπυσίνη; pH-ευαίσθητη αποδέσμευση; Ορθοπεδικά μοσχεύματα; Bioactive nanospheres; Dextran hydrogels; Doxorubicin; pH-sensitive release; Orthopedic implants

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Angelopoulou, A. (2013). Μελέτη υλικών βιολογικού ενδιαφέροντος μέσω προηγμένων φασματοσκοπικών τεχνικών. (Thesis). University of Patras; Πανεπιστήμιο Πατρών. Retrieved from http://hdl.handle.net/10442/hedi/31772

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Angelopoulou, Athina. “Μελέτη υλικών βιολογικού ενδιαφέροντος μέσω προηγμένων φασματοσκοπικών τεχνικών.” 2013. Thesis, University of Patras; Πανεπιστήμιο Πατρών. Accessed January 18, 2021. http://hdl.handle.net/10442/hedi/31772.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Angelopoulou, Athina. “Μελέτη υλικών βιολογικού ενδιαφέροντος μέσω προηγμένων φασματοσκοπικών τεχνικών.” 2013. Web. 18 Jan 2021.

Vancouver:

Angelopoulou A. Μελέτη υλικών βιολογικού ενδιαφέροντος μέσω προηγμένων φασματοσκοπικών τεχνικών. [Internet] [Thesis]. University of Patras; Πανεπιστήμιο Πατρών; 2013. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10442/hedi/31772.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Angelopoulou A. Μελέτη υλικών βιολογικού ενδιαφέροντος μέσω προηγμένων φασματοσκοπικών τεχνικών. [Thesis]. University of Patras; Πανεπιστήμιο Πατρών; 2013. Available from: http://hdl.handle.net/10442/hedi/31772

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

17. Moura, Lucas Alves, 1981-. Preparo, caracterização e avaliação do uso de nanoesferas de PLGA contendo doxiciclina associado ao debridamento periodontal no tratamento da periodontite crônica avançada = Preparation, characterization ans evaluation of the adjunctive use of PLGA nanospheres loading doxycycline to periodontal debridement on treatment of advanced chronic periodontitis: Preparation, characterization ans evaluation of the adjunctive use of PLGA nanospheres loading doxycycline to periodontal debridement on treatment of advanced chronic periodontitis.

Degree: 2015, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/290385

► Abstract: The aim of this study was to assess the effect of the association of local administration of nanospheres loading doxycycline (DOX) with the periodontal… (more)

▼ Abstract: The aim of this study was to assess the effect of the association of local administration of nanospheres loading doxycycline (DOX) with the periodontal debridement treating advanced chronic periodontitis. Nanospheres were made by double-emulsion method (W/O/W) and characterized regarding morphology, by scaning eléctron microscopy (SEM); and drug/polymer interaction, by Fourier transform infrared spectroscopy (FTIR). The DOX controlled release was assessed by high performance liquid chromatography (HPLC) of gingival crevicular fluid (GCF) samples collected 2, 5, 7, 10, 15 and 20 days after treatment. It was performed randomized double-blinded clinical trial, with thirty patients diagnosed with chronic periodontitis presenting at least seven sites with bleeding on probing and probing depth (PD) ? 5 mm, and 2 sites with PD ? 7 mm. The patients were randomly allocated in two groups receiving interventions as followed: 45 minutes periodontal debridement + subgengival nanospheres loading DOX (DB+DOX); and 45 minutes periodontal debridement + subgengival void nanospheres (DB). Plaque index (IP), bleeding on probing (BP), probing depth (PD) and clinical attachment level (CAL) were evaluated on baseline, 3, and 6 months after therapy. Real-time polymerase chain reaction (real-time PCR) was used to quantify Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Aggregatibacter actinomycetemcomitans and Prevotella intermedia from subgingival biofilm samples collected on baseline, 1, 3 and 6 months after treatment. The results were compared by variance analyses test for repeated measures, with significance of 5%. Nanospheres varying from 700 nm to 4 um were obtained. There was a good interaction between DOX and PLGA, with no chemical properties alterations. After local administration of the nanospheres, it was observed constant DOX release in the GCF until 20th day post-treatment, with concentration above the minimum inhibitory concentration. DB+DOX group showed significant PD reduction and CAL gain in deep and moderates pockets comparing to baseline and between groups. It was observed significant reduction of bacteria levels along follow up period, and DB+DOX group was more eficiente in keeping lower levels of bacteria after 6 months from treatment. Within limitations of this study, the results can suggest that PLGA nanospheres are effective carriers for controlled release of DOX and when used adjunctively to periodontal debridement, improved results can be achieved compared to mechanical therapy alone Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Sallum, Antonio Wilson, 1943- (advisor), Universidade Estadual de Campinas. Faculdade de Odontologia de Piracicaba (institution), Programa de Pós-Graduação em Clínica Odontológica (nameofprogram), Peruzzo, Daiane Cristina (committee member), Santamaria, Mauro Pedrine (committee member), Silvério, Karina Gonzales (committee member), Casarin, Renato Corrêa Viana (committee member).

Subjects/Keywords: Periodontite crônica; Nanoesferas; Sistemas de liberação de medicamentos; Doxiciclina; Plásticos biodegradáveis; Chronic periodontitis; Nanospheres; Drug delivery systems; Doxycycline; Biodegradable plastics

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Moura, Lucas Alves, 1. (2015). Preparo, caracterização e avaliação do uso de nanoesferas de PLGA contendo doxiciclina associado ao debridamento periodontal no tratamento da periodontite crônica avançada = Preparation, characterization ans evaluation of the adjunctive use of PLGA nanospheres loading doxycycline to periodontal debridement on treatment of advanced chronic periodontitis: Preparation, characterization ans evaluation of the adjunctive use of PLGA nanospheres loading doxycycline to periodontal debridement on treatment of advanced chronic periodontitis. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/290385

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Moura, Lucas Alves, 1981-. “Preparo, caracterização e avaliação do uso de nanoesferas de PLGA contendo doxiciclina associado ao debridamento periodontal no tratamento da periodontite crônica avançada = Preparation, characterization ans evaluation of the adjunctive use of PLGA nanospheres loading doxycycline to periodontal debridement on treatment of advanced chronic periodontitis: Preparation, characterization ans evaluation of the adjunctive use of PLGA nanospheres loading doxycycline to periodontal debridement on treatment of advanced chronic periodontitis.” 2015. Thesis, Universidade Estadual de Campinas. Accessed January 18, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290385.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Moura, Lucas Alves, 1981-. “Preparo, caracterização e avaliação do uso de nanoesferas de PLGA contendo doxiciclina associado ao debridamento periodontal no tratamento da periodontite crônica avançada = Preparation, characterization ans evaluation of the adjunctive use of PLGA nanospheres loading doxycycline to periodontal debridement on treatment of advanced chronic periodontitis: Preparation, characterization ans evaluation of the adjunctive use of PLGA nanospheres loading doxycycline to periodontal debridement on treatment of advanced chronic periodontitis.” 2015. Web. 18 Jan 2021.

Vancouver:

Moura, Lucas Alves 1. Preparo, caracterização e avaliação do uso de nanoesferas de PLGA contendo doxiciclina associado ao debridamento periodontal no tratamento da periodontite crônica avançada = Preparation, characterization ans evaluation of the adjunctive use of PLGA nanospheres loading doxycycline to periodontal debridement on treatment of advanced chronic periodontitis: Preparation, characterization ans evaluation of the adjunctive use of PLGA nanospheres loading doxycycline to periodontal debridement on treatment of advanced chronic periodontitis. [Internet] [Thesis]. Universidade Estadual de Campinas; 2015. [cited 2021 Jan 18]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/290385.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Moura, Lucas Alves 1. Preparo, caracterização e avaliação do uso de nanoesferas de PLGA contendo doxiciclina associado ao debridamento periodontal no tratamento da periodontite crônica avançada = Preparation, characterization ans evaluation of the adjunctive use of PLGA nanospheres loading doxycycline to periodontal debridement on treatment of advanced chronic periodontitis: Preparation, characterization ans evaluation of the adjunctive use of PLGA nanospheres loading doxycycline to periodontal debridement on treatment of advanced chronic periodontitis. [Thesis]. Universidade Estadual de Campinas; 2015. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/290385

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Federal de Santa Maria

18. Camila Ferrazza Alves. NANOCÁPSULAS E NANOESFERAS DE DISSELENETO DE DIFENILA: SÍNTESE E DISTRIBUIÇÃO BIOLÓGICA.

Degree: 2012, Universidade Federal de Santa Maria

URL: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=4515

►

Nos últimos anos, os compostos orgânicos de selênio têm sido alvos de interesse em síntese orgânica em virtude da descoberta de suas aplicações sintéticas e… (more)

▼

Nos últimos anos, os compostos orgânicos de selênio têm sido alvos de interesse em síntese orgânica em virtude da descoberta de suas aplicações sintéticas e de suas propriedades farmacológicas. O disseleneto de difenila (PhSe)2 é um composto orgânico de selênio que apresenta diversos efeitos farmacológicos descritos, porém a pouca solubilidade em água e baixa biodisponibilidade oral podem ser um limite para seu uso clínico. Nanopartículas poliméricas vem sendo um importante modelo para o carreamento de fármacos, apresentando vantagens como maior biodisponibilidade, direcionamento a sítios específicos e possibilidade de encapsulamento de compostos lipofílicos de maneira bastante eficiente. Tendo em vista a busca pelo desenvolvimento de um sistema de controle da liberação de fármacos, este trabalho teve como objetivo preparar nanoesferas e nanocápsulas de (PhSe)2 através do método de deposição interfacial do polímero pré-formado utilizando diferentes óleos (miglyol, óleo de canola e ômega-3) como como núcleo oleoso. As nanocápsulas foram caracterizadas através da medida do pH, tamanho médio de partícula, índice de polidispersão, potencial zeta, taxa de associação e doseamento do (PhSe)2. Os resultados das formulações desenvolvidas apresentaram uma distribuição do tamanho de partícula com um índice de polidispersão de até 0,2; diâmetro médio inferior a 330 nm; o potencial zeta foi superior a -16 mV, onde a taxa de encapsulamento encontrada foi de 99,9% para todas as formulações desenvolvidas. Os ensaios biológicos feitos em camundongos com as nanocápsulas de (PhSe)2 contendo óleo de canola como núcleo oleoso mostraram maior biodisponibilidade das nanocápsulas de (PhSe)2 em comparação com o (PhSe)2 livre, mostrando uma proeminente influencia dos sistemas nanoparticulados nas propriedades biológicas de compostos organocalcogênio.

In last years, selenium organic compounds of selenium have been targets of interest in organic synthesis because of their synthetic application and their pharmacological properties. Diphenyl diselenide (PhSe)2 is an organic compound of selenium that has several pharmacological effects; however the poor water-solubility and low oral bioavailability can be a limit for its clinical utility. Polymeric nanoparticles has been an impotant model to carry drugs with advantages such as increase bioavailability, targeting to specific sites and the possibility of encapsulation of lipophilic compounds quite efficiently. In view of the quest for developing a system to control drug release and improve its oral bioavailability, this study aims to prepare nanospheres and nanocapsules of (PhSe)2 by the interfacial deposition method of preformed polymer cores using different oils (miglyol, canola oil and omega-3) as the oil core. The nanocapsules will be characterized by measuring the pH, mean particle size, polydispersity index, zeta potential, rate of association and determination of (PhSe)2. By adjusting the process parameters, the results of the optimized formulation showed a size distribution with a…

Advisors/Committee Members: Luciano Dornelles, Oscar Endrigo Dorneles Rodrigues, Cristiane Luchese.

Subjects/Keywords: Disseleneto de difenila. Nanocápsula. Nanoesfera. Excreção. Distribuição.; CIENCIAS BIOLOGICAS; Keywords: Diphenyl diselenide. Nanocapsules. Nanospheres. Excretion. Distribution.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Alves, C. F. (2012). NANOCÁPSULAS E NANOESFERAS DE DISSELENETO DE DIFENILA: SÍNTESE E DISTRIBUIÇÃO BIOLÓGICA. (Thesis). Universidade Federal de Santa Maria. Retrieved from http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=4515

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Alves, Camila Ferrazza. “NANOCÁPSULAS E NANOESFERAS DE DISSELENETO DE DIFENILA: SÍNTESE E DISTRIBUIÇÃO BIOLÓGICA.” 2012. Thesis, Universidade Federal de Santa Maria. Accessed January 18, 2021. http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=4515.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Alves, Camila Ferrazza. “NANOCÁPSULAS E NANOESFERAS DE DISSELENETO DE DIFENILA: SÍNTESE E DISTRIBUIÇÃO BIOLÓGICA.” 2012. Web. 18 Jan 2021.

Vancouver:

Alves CF. NANOCÁPSULAS E NANOESFERAS DE DISSELENETO DE DIFENILA: SÍNTESE E DISTRIBUIÇÃO BIOLÓGICA. [Internet] [Thesis]. Universidade Federal de Santa Maria; 2012. [cited 2021 Jan 18]. Available from: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=4515.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Alves CF. NANOCÁPSULAS E NANOESFERAS DE DISSELENETO DE DIFENILA: SÍNTESE E DISTRIBUIÇÃO BIOLÓGICA. [Thesis]. Universidade Federal de Santa Maria; 2012. Available from: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=4515

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Kabirian Dehkordi, Samaneh. Biological Activities of Nucleolin Aptamer AS1411 Grafted to Gold Nanospheres : From Synthesis to Mechanistic Studies : Activités biologiques de l'aptamère nucléoline AS1411 associé à nanosphères d'or : de la synthèse aux études mécanistiques.

Degree: Docteur es, Biologie, 2019, Lyon; Université de technologie d'Isfahan (Isfahan, Iran)

URL: http://www.theses.fr/2019LYSE1216

►

Un oligonucléotide riche en G, AS1411, interagi avec la nucléoline et inhibe la prolifération des cellules cancéreuses et la croissance tumorale. Cette action antiproliférative est… (more)

▼

Un oligonucléotide riche en G, AS1411, interagi avec la nucléoline et inhibe la prolifération des cellules cancéreuses et la croissance tumorale. Cette action antiproliférative est augmentée lorsqu’AS1411 est conjugué à différents types de nanoparticules. Cependant, les mécanismes moléculaires impliqués demeurent inconnusDans ce travail, nous montrons dans des cellules HeLa que l'optimisation des nanopshères d'or conjuguées à l'AS1411 (GNS-AS1411) inhibe l'expression de la nucléoline aux niveaux des ARN et des protéines. Une altération de la structure nucléolaire avec une diminution de l’accumulation des ARN ribosomaux comparable à celle engendrée par un knock-down de la nucléoline a été observée. Toutefois, l'expression des gènes impliqués dans le cycle cellulaire et le blocage du cycle cellulaire par GNS-AS1411 n’est pas régulée de la même manière que dans les cellules où la nucléoline a été inactivée. Ces données suggèrent que l'activité antiproliférative du complexe GNS-AS1411 n'est pas la seule conséquence du ciblage et de la régulation négative de la nucléoline

A G-rich oligonucleotide, AS1411, has been shown to interact with nucleolin and to inhibit cancer cell proliferation and tumor growth. This antiproliferative action is increased when AS1411 is conjugated to different types of nanoparticles. However, the molecular mechanisms are not known. In this work, we show in HeLa cells that optimized AS1411-conjugated gold nanospheres (GNS-AS1411) inhibit nucleolin expression at the RNA and protein levels. We observed an alteration of the nucleolar structure with a decrease of ribosomal RNA accumulation comparable to what is observed upon nucleolin knock down. However, the expression of genes involved in cell cycle and the cell cycle blockage by GNS-AS1411 are not regulated in the same way that in cells where nucleolin has been knock down. These data suggest that the anti-proliferative activity of GNS-AS1411 is not the only consequence of nucleolin targeting and down regulation

Advisors/Committee Members: Bouvet, Philippe (thesis director), Mehrgardi, Masoud (thesis director).

Subjects/Keywords: AS1411; Nanosphères d'or; Nucléoline; Structure nucléolaire; ARN ribosomaux; AS1411; Gold nanospheres; Nucleolin; Cell cycle; Nucleolar structure; Ribosomal RNA; 570

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kabirian Dehkordi, S. (2019). Biological Activities of Nucleolin Aptamer AS1411 Grafted to Gold Nanospheres : From Synthesis to Mechanistic Studies : Activités biologiques de l'aptamère nucléoline AS1411 associé à nanosphères d'or : de la synthèse aux études mécanistiques. (Doctoral Dissertation). Lyon; Université de technologie d'Isfahan (Isfahan, Iran). Retrieved from http://www.theses.fr/2019LYSE1216

Chicago Manual of Style (16^th Edition):

Kabirian Dehkordi, Samaneh. “Biological Activities of Nucleolin Aptamer AS1411 Grafted to Gold Nanospheres : From Synthesis to Mechanistic Studies : Activités biologiques de l'aptamère nucléoline AS1411 associé à nanosphères d'or : de la synthèse aux études mécanistiques.” 2019. Doctoral Dissertation, Lyon; Université de technologie d'Isfahan (Isfahan, Iran). Accessed January 18, 2021. http://www.theses.fr/2019LYSE1216.

MLA Handbook (7^th Edition):

Kabirian Dehkordi, Samaneh. “Biological Activities of Nucleolin Aptamer AS1411 Grafted to Gold Nanospheres : From Synthesis to Mechanistic Studies : Activités biologiques de l'aptamère nucléoline AS1411 associé à nanosphères d'or : de la synthèse aux études mécanistiques.” 2019. Web. 18 Jan 2021.

Vancouver:

Kabirian Dehkordi S. Biological Activities of Nucleolin Aptamer AS1411 Grafted to Gold Nanospheres : From Synthesis to Mechanistic Studies : Activités biologiques de l'aptamère nucléoline AS1411 associé à nanosphères d'or : de la synthèse aux études mécanistiques. [Internet] [Doctoral dissertation]. Lyon; Université de technologie d'Isfahan (Isfahan, Iran); 2019. [cited 2021 Jan 18]. Available from: http://www.theses.fr/2019LYSE1216.

Council of Science Editors:

Kabirian Dehkordi S. Biological Activities of Nucleolin Aptamer AS1411 Grafted to Gold Nanospheres : From Synthesis to Mechanistic Studies : Activités biologiques de l'aptamère nucléoline AS1411 associé à nanosphères d'or : de la synthèse aux études mécanistiques. [Doctoral Dissertation]. Lyon; Université de technologie d'Isfahan (Isfahan, Iran); 2019. Available from: http://www.theses.fr/2019LYSE1216

20. Lakić, Marijana. Razvoj votlih nanosfer za uporabo v okoljevarstvu.

Degree: 2012, Univerza v Mariboru

URL: https://dk.um.si/IzpisGradiva.php?id=37159 ; https://dk.um.si/Dokument.php?id=49420&dn= ; https://plus.si.cobiss.net/opac7/bib/16453398?lang=sl

►

Votle magnetne nanosfere imajo velik potencial v okoljevarstvu v senzorskih aplikacijah za določevanje prisotnosti onesnaževal in kot adsorpcijska sredstva za čiščenje težkih kovin iz voda.… (more)

Subjects/Keywords: nanotehnologija; magnetizem; železovi oksidi; votle magnetne nanosfere; nanotechnology; magnetism; iron oxides; hollow magnetic nanospheres; info:eu-repo/classification/udc/544.725:628.3(043.3)

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lakić, M. (2012). Razvoj votlih nanosfer za uporabo v okoljevarstvu. (Masters Thesis). Univerza v Mariboru. Retrieved from https://dk.um.si/IzpisGradiva.php?id=37159 ; https://dk.um.si/Dokument.php?id=49420&dn= ; https://plus.si.cobiss.net/opac7/bib/16453398?lang=sl

Chicago Manual of Style (16^th Edition):

Lakić, Marijana. “Razvoj votlih nanosfer za uporabo v okoljevarstvu.” 2012. Masters Thesis, Univerza v Mariboru. Accessed January 18, 2021. https://dk.um.si/IzpisGradiva.php?id=37159 ; https://dk.um.si/Dokument.php?id=49420&dn= ; https://plus.si.cobiss.net/opac7/bib/16453398?lang=sl.

MLA Handbook (7^th Edition):

Lakić, Marijana. “Razvoj votlih nanosfer za uporabo v okoljevarstvu.” 2012. Web. 18 Jan 2021.

Vancouver:

Lakić M. Razvoj votlih nanosfer za uporabo v okoljevarstvu. [Internet] [Masters thesis]. Univerza v Mariboru; 2012. [cited 2021 Jan 18]. Available from: https://dk.um.si/IzpisGradiva.php?id=37159 ; https://dk.um.si/Dokument.php?id=49420&dn= ; https://plus.si.cobiss.net/opac7/bib/16453398?lang=sl.

Council of Science Editors:

Lakić M. Razvoj votlih nanosfer za uporabo v okoljevarstvu. [Masters Thesis]. Univerza v Mariboru; 2012. Available from: https://dk.um.si/IzpisGradiva.php?id=37159 ; https://dk.um.si/Dokument.php?id=49420&dn= ; https://plus.si.cobiss.net/opac7/bib/16453398?lang=sl

University of Waterloo

21. Yang, Hong. Synthesis and Characterization of Nanostructured Semiconductor Materials by Self-assembling Methods.

Degree: 2008, University of Waterloo

URL: http://hdl.handle.net/10012/3528

► This thesis reported synthesis of TiO2 nanostructures and Fe2O3 nanostructures and studied on self-assembling process. The morphologies, compositions, and physicochemical properties of the prepared samples… (more)

▼ This thesis reported synthesis of TiO2 nanostructures and Fe2O3 nanostructures and studied on self-assembling process. The morphologies, compositions, and physicochemical properties of the prepared samples were characterized by TEM, FESEM, XRD, FTIR, UV, and SQUID etc. Nanoparticles of transition metal oxides own their special function to become an interesting hot research topic in the recent decades. In particular, superparamagnetic iron oxide nanoparticles can be used as drug delivery agent and new hard disc drive materials. They have wide application in environment industry as well. Titanium dioxide nanoparticles can be applied in photocatalysts, UV protectors and dye sensitive solar cell etc. Their wide industrial applications for advanced technology development motivate scientists to develop simple, economical and novel synthetic methods, and explore their applications, so that the commercialization of the production of the nanomaterials becomes feasible. The objective of this project is to develop an effective, simple and economical technical route for synthesis of nanosized iron oxide and titanium oxide particles/rods/films. The approach and the progress are outlined as follows. Based on extensive literature reading on the project related area, a novel self-assembling technical route for iron oxide nanostructure and architecture was proposed which has been confirmed to be effective. Detailed experimental investigation on the synthesis of nanoparticles/rods, and instrumental characterization of the particle size, structure, and crystallites, etc. via TEM, FESEM, XRD, FTIR, UV, SQUID are conducted. Uniform nanorods of hematite iron oxide and titanium oxide nanospheres, and anatase TiO2 thin film with micropores have been successfully achieved. Some preliminary exploration for applications of the synthesized nanomaterials has also been carried out. Firstly, a novel assembled scheme of iron oxide nanostructure and architecture by selfassembling process was investigated. The sol-gel technical route was employed to synthesize nearly uniform nanorods of hematite particles. Morphologies and physicochemical properties of iron oxide nanostructure were characterized by analytical instrument. Secondly, titanium oxide nanospheres were synthesized via a hydrothermal process using titanium isopropoxide as the precursor. Titanium oxide nanospheres with inner nanospace andhighly organized crystallites in the shell structure and surface regions were synthesized. It demonstrated that the technical route developed in this work has a high versatility for structural engineering of various targeted morphological products. Thirdly, a simple process of preparing anatase TiO2 thin film with micropores was pursued. The synthesized nano thin film with micropores was used for the material of dye-sensitive solar cell; and effective electron transfer of titanium oxide electrode was confirmed by electrochemical voltammetry. Preparation of the titanium oxide electrode and its electrochemical analysis was…

Subjects/Keywords: synthesis; nanoparticles; nanorods; nanospheres; self-assembling; iron oxide

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yang, H. (2008). Synthesis and Characterization of Nanostructured Semiconductor Materials by Self-assembling Methods. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/3528

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yang, Hong. “Synthesis and Characterization of Nanostructured Semiconductor Materials by Self-assembling Methods.” 2008. Thesis, University of Waterloo. Accessed January 18, 2021. http://hdl.handle.net/10012/3528.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yang, Hong. “Synthesis and Characterization of Nanostructured Semiconductor Materials by Self-assembling Methods.” 2008. Web. 18 Jan 2021.

Vancouver:

Yang H. Synthesis and Characterization of Nanostructured Semiconductor Materials by Self-assembling Methods. [Internet] [Thesis]. University of Waterloo; 2008. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10012/3528.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yang H. Synthesis and Characterization of Nanostructured Semiconductor Materials by Self-assembling Methods. [Thesis]. University of Waterloo; 2008. Available from: http://hdl.handle.net/10012/3528

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Louisiana State University

22. Astete R., Carlos Ernesto. Synthesis of poly(DL-lactide-co-glycolide) nanoparticles with entrapped magnetite.

Degree: MSBAE, Engineering, 2005, Louisiana State University

URL: etd-11152005-124938 ; https://digitalcommons.lsu.edu/gradschool_theses/2254

► The goal of the research was to synthesize magnetic polymeric nanoparticles (MPNPs) under 100 nm in diameter, for future drug delivery applications. The thesis is… (more)

Subjects/Keywords: emulsion evaporation; nanospheres; top-down techniques; nanotechnology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Astete R., C. E. (2005). Synthesis of poly(DL-lactide-co-glycolide) nanoparticles with entrapped magnetite. (Masters Thesis). Louisiana State University. Retrieved from etd-11152005-124938 ; https://digitalcommons.lsu.edu/gradschool_theses/2254

Chicago Manual of Style (16^th Edition):

Astete R., Carlos Ernesto. “Synthesis of poly(DL-lactide-co-glycolide) nanoparticles with entrapped magnetite.” 2005. Masters Thesis, Louisiana State University. Accessed January 18, 2021. etd-11152005-124938 ; https://digitalcommons.lsu.edu/gradschool_theses/2254.

MLA Handbook (7^th Edition):

Astete R., Carlos Ernesto. “Synthesis of poly(DL-lactide-co-glycolide) nanoparticles with entrapped magnetite.” 2005. Web. 18 Jan 2021.

Vancouver:

Astete R. CE. Synthesis of poly(DL-lactide-co-glycolide) nanoparticles with entrapped magnetite. [Internet] [Masters thesis]. Louisiana State University; 2005. [cited 2021 Jan 18]. Available from: etd-11152005-124938 ; https://digitalcommons.lsu.edu/gradschool_theses/2254.

Council of Science Editors:

Astete R. CE. Synthesis of poly(DL-lactide-co-glycolide) nanoparticles with entrapped magnetite. [Masters Thesis]. Louisiana State University; 2005. Available from: etd-11152005-124938 ; https://digitalcommons.lsu.edu/gradschool_theses/2254

University of Akron

23. Hindi, Khadijah M. The Medicinal Applications and Stability Evaluation of Silver (I) Carbene Complexes.

Degree: PhD, Chemistry, 2008, University of Akron

URL: http://rave.ohiolink.edu/etdc/view?acc_num=akron1217301493

► The formation of the first transition metal complexes of N-heterocyclic carbenes (NHCs) by ændash;fele and Wanzlick in 1968 and the discovery of the first stable… (more)

▼ The formation of the first transition metal complexes of N-heterocyclic carbenes (NHCs) by ændash;fele and Wanzlick in 1968 and the discovery of the first stable and isolable free carbenes by Arduengo in 1991 fostered the growth of this fundamental area of chemical research. Currently, NHCs and their metal complexes are intensely studied for applications such as catalysis and most recently their pharmaceutical properties. The latter has shown promising results and thus will be the primary focus of this dissertation. In general, this dissertation will provide a description of the synthesis and antimicrobial properties of a novel class of silver NHC complexes derived from 4,5-dichloroimidazole and a comparison of its enhanced stability in relation to other silver NHCs synthesized in our laboratory. Chapter 1, the introduction, provides an overview of the medicinal applications of various metal NHC complexes including silver, gold, ruthenium, rhodium, and palladium. This follows a necessary discussion of the known properties of the metals including antimicrobial, antitumor, toxicity, resistance and proposed mechanisms of action. Chapter 2, discusses the synthesis, properties, and antimicrobial activity of a silver(I) acetate NHC complex derived from 4,5-dichloroimidazole with enhanced stability. This discussion is coupled with a comparison to two other structurally similar complexes lacking similar enhanced stability properties. Chapter 3 will provide a detailed account of the stability of the silver NHC complex reported in chapter 2 in various forms of aqueous media formulations including D2O, 0.9% NaCl/D2O, and broth/D2O mixtures utilizing NMR spectral techniques. Chapter 4 will focus on the synthesis of a silver NHC complex bearing a lipophilic substituent, its incorporation into L-tyrosine polyphosphate (LTP) nanospheres, and its in vivo antimicrobial efficacy when delivered to mice inoculated with Pseudomonas aeruginosa. Chapter 5 is devoted to the synthesis and characterization of imidazolium salt precursors functionalized with a variety of substituents and their corresponding silver NHC complexes. In chapter 6, the potential use of several different silver NHC complexes as a treatment of Onychomycosis, a common fungal infection of the nails is explored. The in vitro antifungal activity and penetration potential is reported. Advisors/Committee Members: Youngs, Wiley (Advisor), Tessier, Claire (Advisor).

Subjects/Keywords: Chemistry; NMR; nanospheres; ¿¿¿¿¿; broth/D2O; SILVER; NHCs; COMPLEXES

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hindi, K. M. (2008). The Medicinal Applications and Stability Evaluation of Silver (I) Carbene Complexes. (Doctoral Dissertation). University of Akron. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=akron1217301493

Chicago Manual of Style (16^th Edition):

Hindi, Khadijah M. “The Medicinal Applications and Stability Evaluation of Silver (I) Carbene Complexes.” 2008. Doctoral Dissertation, University of Akron. Accessed January 18, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1217301493.

MLA Handbook (7^th Edition):

Hindi, Khadijah M. “The Medicinal Applications and Stability Evaluation of Silver (I) Carbene Complexes.” 2008. Web. 18 Jan 2021.

Vancouver:

Hindi KM. The Medicinal Applications and Stability Evaluation of Silver (I) Carbene Complexes. [Internet] [Doctoral dissertation]. University of Akron; 2008. [cited 2021 Jan 18]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=akron1217301493.

Council of Science Editors:

Hindi KM. The Medicinal Applications and Stability Evaluation of Silver (I) Carbene Complexes. [Doctoral Dissertation]. University of Akron; 2008. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=akron1217301493

24. Markou, Anastasios. Nanostructured high magnetic anisotopy Pt-TM (TM=Co, Fe, Cr) films.

Degree: 2014, University of Ioannina; Πανεπιστήμιο Ιωαννίνων

URL: http://hdl.handle.net/10442/hedi/39605

►

The 3d transition metal alloys are today prospective materials for high density magnetic recording. These include the chemically ordered FePt, CoPt, CrPt3 alloys and the… (more)

▼

The 3d transition metal alloys are today prospective materials for high density magnetic recording. These include the chemically ordered FePt, CoPt, CrPt3 alloys and the Co/Pt superlattices. The main goal of this work is to provide a comprehensive morphological, structural and magnetic characterization of nanostructured films. The work focuses on four different areas that deal with the optimization of these materials by control of their magnetic anisotropy and microstructural characteristics.Firstly, the effect of layering and thickness studied in CrPt3 and CoPt films: In films obtained by heat-treatment of bilayers and trilayers (of different Co/Pt content) higher degree of chemical ordering and coercivity can be achieved compared to single layer films. The TEM analysis of Co-Pt films reveals that the twin density in trilayers is larger compared to single layers. The average size of grains in CoPt single layers are 32nm, while the average size of Co/CoPt/Pt trilayers is 42nm.Secondly, the study of the effect of layering and magnetic annealing on the texture of Co/Pt multilayers shows that the (001) texture sets in as a result of transformation strain driven selective grain growth of (001) at expense of the other possible textures. This correlation between strain and texture is clear only for magnetically annealed samples. This shows that the main function of the applied field is to correlate local strains in a macroscopic level thus increasing their effect along with directly driving the formation of easy axis (001) towards its direction. Thirdly, the study of switching behavior of regular magnetic FePt nanoislands obtained by sputter deposition of the magnetic layer on monolayers of polystyrene nanospheres (of 970nm and 173nm diameter) used as masks. The nanoislands are magnetically hard and are characterized by non-zero dM-plots. These findings were compared with micromagnetic modeling studies which shows that for anisotropy values high enough to match the observed coercivity, multidomain islands can result in due to the existence of either a softer part or different anisotropy direction part within each magnetic entity. Finally, the previous approach is extended to the study of magnetization reversal in graded anisotropy Co/Pt multilayers which are deposited both onto nanospheres and Si substrates for comparison. The study was based on First Order Reversal Curve diagrams (FORC). Using regular nanostructures the following complication that the study of grade anisotropy films presents, can be dealt with if the thickness exceeds a certain limit above which the formation of stripe domains becomes favorable the straight forward interpretation of the effect of the anisotropy profile on the reversal is not possible. It is found that multilayers can be used to create model graded perpendicular anisotropy systems only when lateral domain propagation is suppressed by appropriate nanostructuration.

Στην παρούσα εργασία πραγματοποιήθηκε ο μορφολογικός, μαγνητικός και δομικός χαρακτηρισμός νανοδομημένων υμενίων υψηλής…

Subjects/Keywords: Νανοτεχνολογία; Μαγνητική εγγραφή; Λεπτά υμένια; Πολυστρωματικά υμένια; Μαγνητισμός; ΚΑΘΕΤΗ ΑΝΙΣΟΤΡΟΠΙΑ; Νανόσφαιρες; Μαγνητική ανόπτηση; Νanotechnology; Magnetic recording; Thin films; Multilayers; Magnetism; PERPENDICULAR ANISOTROPY; Nanospheres; Magnetic Annealing

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Markou, A. (2014). Nanostructured high magnetic anisotopy Pt-TM (TM=Co, Fe, Cr) films. (Thesis). University of Ioannina; Πανεπιστήμιο Ιωαννίνων. Retrieved from http://hdl.handle.net/10442/hedi/39605

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Markou, Anastasios. “Nanostructured high magnetic anisotopy Pt-TM (TM=Co, Fe, Cr) films.” 2014. Thesis, University of Ioannina; Πανεπιστήμιο Ιωαννίνων. Accessed January 18, 2021. http://hdl.handle.net/10442/hedi/39605.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Markou, Anastasios. “Nanostructured high magnetic anisotopy Pt-TM (TM=Co, Fe, Cr) films.” 2014. Web. 18 Jan 2021.

Vancouver:

Markou A. Nanostructured high magnetic anisotopy Pt-TM (TM=Co, Fe, Cr) films. [Internet] [Thesis]. University of Ioannina; Πανεπιστήμιο Ιωαννίνων; 2014. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10442/hedi/39605.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Markou A. Nanostructured high magnetic anisotopy Pt-TM (TM=Co, Fe, Cr) films. [Thesis]. University of Ioannina; Πανεπιστήμιο Ιωαννίνων; 2014. Available from: http://hdl.handle.net/10442/hedi/39605

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

North Carolina State University

25. Shipton, Matthew Kent. The Use of Biodegradable Poly(b-amino ester) and Poly(b-amino amide) Microspheres as an Experimental Therapeutic Delivery Vector for Selective Cancer Cell Targeting.

Degree: MS, Chemistry, 2005, North Carolina State University

URL: http://www.lib.ncsu.edu/resolver/1840.16/1720

► The design, synthesis, and use of new biodegradable polymers for drug delivery applications is an area of ever increasing interest. Polymeric drug delivery systems have… (more)

Subjects/Keywords: gold nanoparticles; polyethylene glycol; nanospheres; microspheres; polymers; Cancer; pH; synthesis of gold

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shipton, M. K. (2005). The Use of Biodegradable Poly(b-amino ester) and Poly(b-amino amide) Microspheres as an Experimental Therapeutic Delivery Vector for Selective Cancer Cell Targeting. (Thesis). North Carolina State University. Retrieved from http://www.lib.ncsu.edu/resolver/1840.16/1720

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shipton, Matthew Kent. “The Use of Biodegradable Poly(b-amino ester) and Poly(b-amino amide) Microspheres as an Experimental Therapeutic Delivery Vector for Selective Cancer Cell Targeting.” 2005. Thesis, North Carolina State University. Accessed January 18, 2021. http://www.lib.ncsu.edu/resolver/1840.16/1720.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shipton, Matthew Kent. “The Use of Biodegradable Poly(b-amino ester) and Poly(b-amino amide) Microspheres as an Experimental Therapeutic Delivery Vector for Selective Cancer Cell Targeting.” 2005. Web. 18 Jan 2021.

Vancouver:

Shipton MK. The Use of Biodegradable Poly(b-amino ester) and Poly(b-amino amide) Microspheres as an Experimental Therapeutic Delivery Vector for Selective Cancer Cell Targeting. [Internet] [Thesis]. North Carolina State University; 2005. [cited 2021 Jan 18]. Available from: http://www.lib.ncsu.edu/resolver/1840.16/1720.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shipton MK. The Use of Biodegradable Poly(b-amino ester) and Poly(b-amino amide) Microspheres as an Experimental Therapeutic Delivery Vector for Selective Cancer Cell Targeting. [Thesis]. North Carolina State University; 2005. Available from: http://www.lib.ncsu.edu/resolver/1840.16/1720

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

26. Ταπεινός, Χρήστος. Σύνθεση και χαρακτηρισμός τροποποιημένων πολυλειτουργικών νανοπεριεκτών.

Degree: 2013, University of Patras

URL: http://hdl.handle.net/10889/7889

► Σκοπός της παρούσας διδακτορικής διατριβής είναι η σύνθεση, ο χαρακτηρισμός και η βιολογική αξιολόγηση τροποποιημένων πολυλειτουργικών νανοπεριεκτών (ΠΝΠ) ως συστημάτων μεταφοράς φαρμάκων (ΣΜΦ), με άμεση… (more)

▼ Σκοπός της παρούσας διδακτορικής διατριβής είναι η σύνθεση, ο χαρακτηρισμός και η βιολογική αξιολόγηση τροποποιημένων πολυλειτουργικών νανοπεριεκτών (ΠΝΠ) ως συστημάτων μεταφοράς φαρμάκων (ΣΜΦ), με άμεση εφαρμογή στη θεραπεία του καρκίνου του μαστού και του προστάτη. Με τον όρο νανοπεριέκτες (ΝΠ) εννοούμε τα σωματίδια τα οποία βρίσκονται στην κλίμακα του νανομέτρου και κυμαίνονται σε διαστάσεις από περίπου 1nm έως και 100 nm. Ο όρος πολυλειτουργικά αναφέρεται στις ιδιότητες αυτών των νανοδομών και πιο συγκεκριμένα στο πως μεταβάλλονται οι ιδιότητες αυτών όταν υπάρχει επίδραση εξωτερικών παραγόντων όπως θερμοκρασία, pH, όξειδο-αναγωγικό περιβάλλον και μεταβαλλόμενο μαγνητικό πεδίο. Για την παρασκευή των πολυμερικών νανοπεριεκτών χρησιμοποιήθηκαν διάφορα είδη πολυμερισμών όπως, πολυμερισμός γαλακτώματος μέσω ριζών, πολυμερισμός σπόρου (seed), πολυμερισμός μεταφοράς ατόμου με ρίζες, πολυμερισμός διασποράς και πολυμερισμός μέσω απόσταξης-καταβύθισης. Οι διάφορες ευαισθησίες στα ΝΣ προστέθηκαν μέσω συμπολυμερισμού διαφόρων μονομερών τα οποία παρουσιάζουν τις προαναφερθείσες ιδιότητες. Κάποια από τα μονομερή τα οποία χρησιμοποιήθηκαν, όπως το υδρόξυ προπυλικό μεθακρυλαμίδιο (HPMA) το οποίο παρουσιάζει ευαισθησία στη μεταβολή της θερμοκρασίας και το 3-Μεθυλ-N-(2-((2-(3-οξοβουταναμιδο)εθυλ) δισουλαφανυλ)εθυλ)βουτ-3-εναμίδιο (Disulfide) το οποίο παρουσιάζει ευαισθησία στις μεταβολές του όξειδο-αναγωγικού περιβάλλοντος συνετέθησαν στο εργαστήριο, ενώ τα υπόλοιπα ήταν εμπορικά διαθέσιμα. Το κύριο μονομερές το οποίο χρησιμοποιήθηκε στους πολυμερισμούς είναι ο Μεθακρυλικός Μεθυλεστέρας (MMA) το οποίο είναι μη τοξικό και κατά τον πολυμερισμό του δημιουργεί σφαιρικές δομές συγκεκριμένου μεγέθους (νανοσφαίρες). Με τη χρήση του συγκεκριμένου μονομερούς συνετέθησαν συμπολυμερή, τα οποία είναι ευαίσθητα στη θερμοκρασία, στο pH και στο όξειδο-αναγωγικό περιβάλλον ή σε συνδυασμό των παραγόντων αυτών. Οι πολυμερικές νανοσφαίρες-νανοπεριέκτες οι οποίες συνετέθησαν είναι κενές στο εσωτερικό τους, ή είναι της μορφής πυρήνας-κέλυφος, όπου το κέλυφος περιέχει τα μονομερή με τις επιθυμητές ευαισθησίες. Η κοιλότητα η οποία δημιουργείται στο εσωτερικό των νανοσφαιρών, σε ορισμένες περιπτώσεις, έχει ως σκοπό τον εγκλωβισμό φαρμακευτικών ουσιών. Τα φαρμακευτικά μόρια τα οποία χρησιμοποιούνται στην παρούσα διδακτορική διατριβή, είτε στο εσωτερικό των νανοσφαιρών είτε προσδεδεμένα στην επιφάνεια αυτών, είναι η Δοξορουβικίνη (Doxorubicin) και η Δαουνοροβικίνη (Daunorubicin). Η επαγωγή των μαγνητικών ιδιοτήτων στους νανοπεριέκτες πραγματοποιήθηκε με τη σύνθεση μαγνητικών νανοσωματιδίων (ΜΝΣ) τα οποία παρασκευάστηκαν πάνω στην επιφάνειά τους. Η χρήση ενός εναλλασσόμενου μαγνητικού πεδίου αυξάνει τοπικά τη θερμοκρασία με αποτέλεσμα, αφενός να διευκολύνεται η τοπική απελευθέρωση της εγκλωβισμένης φαρμακευτικής ουσίας και αφετέρου, εξαιτίας της υψηλής θερμοκρασίας που αναπτύσσεται τοπικά, να οδηγείται το καρκινικό κύτταρο σε απόπτωση (προγραμματισμένος κυτταρικός θάνατος). Για το χαρακτηρισμό των νανοπεριεκτών χρησιμοποιήθηκε μία πληθώρα τεχνικών.… Advisors/Committee Members: Μπουρόπουλος, Νικόλαος, Tapeinos, Christos, Κόρδας, Γεώργιος, Πουλόπουλος, Παναγιώτης, Περλεπές, Σπυρίδων, Γαλιώτης, Κωνσταντίνος, Κουτσούκος, Πέτρος, Μπακανδρίτσος, Αριστείδης.

Subjects/Keywords: Πολλαπλή ευαισθησία; Νανοσφαίρες; Νανοπεριέκτες; Εγκλωβισμός-απελευθέρωση; Κυτταροτοξική μελέτη; Δοξορουβικίνη; Υπερθερμία; In Vitro και In Vivo μελέτες; 615.19; Multi-stimuli responsive; Nanospheres; Nanocontainers; Loading-release; Cytotoxicity studies; Doxorubicin; Hyperthermia

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ταπεινός, �. (2013). Σύνθεση και χαρακτηρισμός τροποποιημένων πολυλειτουργικών νανοπεριεκτών. (Doctoral Dissertation). University of Patras. Retrieved from http://hdl.handle.net/10889/7889

Chicago Manual of Style (16^th Edition):

Ταπεινός, Χρήστος. “Σύνθεση και χαρακτηρισμός τροποποιημένων πολυλειτουργικών νανοπεριεκτών.” 2013. Doctoral Dissertation, University of Patras. Accessed January 18, 2021. http://hdl.handle.net/10889/7889.

MLA Handbook (7^th Edition):

Ταπεινός, Χρήστος. “Σύνθεση και χαρακτηρισμός τροποποιημένων πολυλειτουργικών νανοπεριεκτών.” 2013. Web. 18 Jan 2021.

Vancouver:

Ταπεινός �. Σύνθεση και χαρακτηρισμός τροποποιημένων πολυλειτουργικών νανοπεριεκτών. [Internet] [Doctoral dissertation]. University of Patras; 2013. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10889/7889.

Council of Science Editors:

Ταπεινός �. Σύνθεση και χαρακτηρισμός τροποποιημένων πολυλειτουργικών νανοπεριεκτών. [Doctoral Dissertation]. University of Patras; 2013. Available from: http://hdl.handle.net/10889/7889

27. Αγγελοπούλου, Αθηνά. Μελέτη υλικών βιολογικού ενδιαφέροντος μέσω προηγμένων φασματοσκοπικών τεχνικών.

Degree: 2012, University of Patras

URL: http://hdl.handle.net/10889/7252

►

Σήμερα η μελέτη των βιοϋλικών προσανατολίζεται σε δύο κατευθύνσεις, την ανάπτυξη συστημάτων μεταφοράς φαρμάκων και συστημάτων κατάλληλων να διεγείρουν κυτταρικές λειτουργίες. Η έρευνά μας έχει… (more)

▼

Σήμερα η μελέτη των βιοϋλικών προσανατολίζεται σε δύο κατευθύνσεις, την ανάπτυξη συστημάτων μεταφοράς φαρμάκων και συστημάτων κατάλληλων να διεγείρουν κυτταρικές λειτουργίες. Η έρευνά μας έχει σχέση με την συγκριτική μελέτη συστημάτων μεταφοράς φαρμάκων κατάλληλων για εφαρμογή σε οστικούς καρκίνους. Τέτοιου είδους συστήματα θα πρέπει, αρχικά να είναι ικανά να μεταφέρουν τα φαρμακευτικά μόρια και στη συνέχεια να μπορούν να επάγουν οστεογένεση. Η δεύτερη λειτουργικότητα είναι ιδιαιτέρως σημαντική καθώς έχει σαν αποτέλεσμα την πλήρωση του οστικού ελλείμματος που προκαλείται από την δράση των καρκινικών κυττάρων. Για τον σκοπό αυτό, διερευνήθηκε η ικανότητα του υαλώδους δικτύου να μεταφέρει φαρμακευτικά μόρια μέσω παραδοσιακών συστημάτων μεταφοράς. Συνεπώς, ακολούθησε η ex vitro μελέτη pH-ευαίσθητων τροποποιημένων πυριτικών ξηρών πηκτών στα οποία είχε συνδεθεί το αντικαρκινικό φάρμακο δοξορουπμυσίνη. Συγκεκριμένα, πυριτικά ξηρά πηκτώματα συντέθηκαν με την μέθοδο sol-gel και τροποποιήθηκαν περαιτέρω με χημεία καρβοδιϊμιδίου. Η τροποποίηση είχε σαν αποτέλεσμα την επιφανειακή σύνδεση υδροπηκτών δεξτράνης που παρουσιάζουν ευαισθησία στο pH. Στη συνέχεια, ακολούθησε η σύνθεση των ανόργανων βιοενεργών νανοσφαιρών. Για την σύνθεση των υαλωδών νανοσφαιρών με εσωτερική κοιλότητα ακολουθήθηκε η διαδικασία επικάλυψης sol-gel, κατά την οποία έγινε η ηλεκτροστατική επικάλυψη νανοσωματιδίων πολυστυρενίου με αποτέλεσμα την σύνθεση ανόργανων πυριτικών και φωσφοπυριτικών νανοσφαιρών. Επιπλέον, μελετήθηκε η εφαρμογή του συμπολυμερούς του πολυμεθακρυλικού μεθυλεστέρα – υδρομεθακρυλικού προπυλεστέρα ως υποστρώματος καθώς το PMMA αποτελεί βασικό συστατικό των οστικών τσιμέντων και παρουσιάζει βελτιωμένες μηχανικές ιδιότητες. Προκειμένου να ολοκληρωθεί η συγκριτική μελέτη μας, ακολούθησε η ex vitro ανάλυση των παραπάνω υβριδικών φωσφοπυριτικών νανοσφαιρών καθώς επίσης των πυριτικών νανοσφαιρών PS και PMMA-co-HPMA. Η επώαση σε διάλυμα SBF οδήγησε στον σχηματισμό ανθρακικού πυριτικού υδροξυαπατίτη με το μέγεθος των κρυσταλλιτών να μην υπερβαίνει τα 45 nm και έντονη παρουσία συσσωματωμάτων. Βέλτιστες ιδιότητες βιοενεργότητας παρουσιάζουν οι τροποποιημένες με αμίνες υβριδικές νανοσφαίρες PMMA-co-HPMA, οι οποίες έχουν επίσης την δυνατότητα να χρησιμοποιηθούν ως μεταφορείς φαρμακευτικών μορίων σε όξινο καθώς επίσης και σε φυσιολογικό pH με παρατεταμένη δυνατότητα αποδέσμευσης.

Recently the study of biomaterials has moved in two directions, the evolution of drug delivery systems and of systems that can stimulate specific cellular responses. Our investigation aims to the study of drug delivery systems for bone cancer therapy. These systems must fulfill two important functionalities. At first, they should be able to deliver drug molecules to bone cancer environment through loading or surface conjugation and subsequently to cause osteogenesis. Their second functionality is especially important since it leads to substitution of bone defects caused from the action of cancer cells. For this purpose, the ability of the glassy network to deliver drug…

Advisors/Committee Members: Φωτεινός, Δημήτριος, Angelopoulou, Athina, Φωτεινός, Δημήτριος, Μπουρόπουλος, Νικόλαος, Περλεπές, Σπυρίδων, Κουτσούκος, Πέτρος, Τοπογλίδης, Εμμανουήλ, Μπακανδρίτσος, Αριστείδης.

Subjects/Keywords: Βιοενεργές νανοσφαίρες; Υδρογέλες δεξτράνης; Δοξορουμπυσίνη; pH-ευαίσθητη αποδέσμευση φαρμάκου; Επιφανειακή τροποποίηση; Συστήματα μεταφοράς φαρμάκων; 615.7; Bioactive nanospheres; Dextran hydrogels; Doxorubicin; pH-sensitive drug release; Surface functionalization; Drug delivery systems

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Αγγελοπούλου, �. (2012). Μελέτη υλικών βιολογικού ενδιαφέροντος μέσω προηγμένων φασματοσκοπικών τεχνικών. (Doctoral Dissertation). University of Patras. Retrieved from http://hdl.handle.net/10889/7252

Chicago Manual of Style (16^th Edition):

Αγγελοπούλου, Αθηνά. “Μελέτη υλικών βιολογικού ενδιαφέροντος μέσω προηγμένων φασματοσκοπικών τεχνικών.” 2012. Doctoral Dissertation, University of Patras. Accessed January 18, 2021. http://hdl.handle.net/10889/7252.

MLA Handbook (7^th Edition):

Αγγελοπούλου, Αθηνά. “Μελέτη υλικών βιολογικού ενδιαφέροντος μέσω προηγμένων φασματοσκοπικών τεχνικών.” 2012. Web. 18 Jan 2021.

Vancouver:

Αγγελοπούλου �. Μελέτη υλικών βιολογικού ενδιαφέροντος μέσω προηγμένων φασματοσκοπικών τεχνικών. [Internet] [Doctoral dissertation]. University of Patras; 2012. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10889/7252.

Council of Science Editors:

Αγγελοπούλου �. Μελέτη υλικών βιολογικού ενδιαφέροντος μέσω προηγμένων φασματοσκοπικών τεχνικών. [Doctoral Dissertation]. University of Patras; 2012. Available from: http://hdl.handle.net/10889/7252

28. Pierre-Bolivar, Marie Carmelle Serviane. Synthesis and characterization of perm-selective SERS-active silica-coated gold nanospheres for the direct detection of small molecules.

Degree: PhD, Chemistry, 2013, University of Iowa

URL: https://ir.uiowa.edu/etd/5042

► Noble metal nanomaterials have numerous uses in plasmonic and surface enhanced Raman scattering (SERS) detection applications; however, upon the addition of analytes, nanomaterials often… (more)

▼ Noble metal nanomaterials have numerous uses in plasmonic and surface enhanced Raman scattering (SERS) detection applications; however, upon the addition of analytes, nanomaterials often undergo uncontrolled aggregation which leads to inconsistent signal intensities. To overcome this limitation, the effect of gold nanosphere concentration, column purification, and surface chemistry functionalization using internally etched silica stabilization methods was investigated on SERS assays for small molecule detection. Nanostructure composition, size, shape, stability, surface chemistry, optical properties, and SERS-activity were monitored using localized surface plasmon resonance (LSPR or extinction) spectroscopy, transmission electron microscopy (TEM), and Raman spectroscopy. First, the behavior of citrate-stabilized gold nanospheres was monitored as a function of molecular surface coverage. Both extinction and SERS spectral intensities increased linearly below monolayer functionalization. Above this value, however, uncontrolled nanoparticle aggregation occurred and large but irreproducible SERS signal intensities were monitored. Next, gold nanoparticles were encapsulated with varying silica shell thicknesses and purified using traditional centrifugation steps and/or column chromatography. Relative to the traditionally purified (i.e. centrifuged) samples, the SERS responses from small molecules using the column purified nanoparticle samples followed a well-known SERS distance-dependence model. Thus, surface chemistry cannot form more than a 2 nm thick layer on gold nanospheres if SERS applications were targeted. To overcome these challenges, gold nanospheres encapsulated with a thick silica shell were made SERS-active by etching the internal silica layer near the metal surface. During the synthesis of these internally etched silica-coated gold nanospheres, the LSPR wavelength shift, a parameter related to the effective local refractive index near the gold core, was monitored instead of etching time, in order to produce nanostructures with more uniform internal silica etching from sample to sample. The SERS-activity of a target molecule using these nanostructures was measured as a function of LSPR wavelength shift. SERS signal intensity increased, which suggested that more analyte molecules were able to bind to the gold surface because of the larger pore size in the silica layer near the metal core. Further exploration of these findings should increase the integration of solution-phase nanoparticles in more predictable functions in future applications, resulting in more quantitative and reproducible molecular detection in complex sample matrices, including biological and environmental samples. Advisors/Committee Members: Haes, Amanda J. (supervisor).

Subjects/Keywords: Nanocomposites; Nanoparticles; Nanospheres; Perm-selective; SERS detection; SERS substrates; Chemistry

…citrate-stabilized gold nanospheres was monitored as a function of molecular surface coverage… …than a 2 nm thick layer on gold nanospheres if SERS applications were targeted. To overcome… …these challenges, gold nanospheres encapsulated with a thick silica shell were made SERS… …these internally etched silica-coated gold nanospheres, v the LSPR wavelength shift, a… …15 22 27 30 PURIFICATION IMPLICATIONS ON SERS-ACTIVITY OF SILICA-COATED GOLD NANOSPHERES…

10 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pierre-Bolivar, M. C. S. (2013). Synthesis and characterization of perm-selective SERS-active silica-coated gold nanospheres for the direct detection of small molecules. (Doctoral Dissertation). University of Iowa. Retrieved from https://ir.uiowa.edu/etd/5042

Chicago Manual of Style (16^th Edition):

Pierre-Bolivar, Marie Carmelle Serviane. “Synthesis and characterization of perm-selective SERS-active silica-coated gold nanospheres for the direct detection of small molecules.” 2013. Doctoral Dissertation, University of Iowa. Accessed January 18, 2021. https://ir.uiowa.edu/etd/5042.

MLA Handbook (7^th Edition):

Pierre-Bolivar, Marie Carmelle Serviane. “Synthesis and characterization of perm-selective SERS-active silica-coated gold nanospheres for the direct detection of small molecules.” 2013. Web. 18 Jan 2021.

Vancouver:

Pierre-Bolivar MCS. Synthesis and characterization of perm-selective SERS-active silica-coated gold nanospheres for the direct detection of small molecules. [Internet] [Doctoral dissertation]. University of Iowa; 2013. [cited 2021 Jan 18]. Available from: https://ir.uiowa.edu/etd/5042.

Council of Science Editors:

Pierre-Bolivar MCS. Synthesis and characterization of perm-selective SERS-active silica-coated gold nanospheres for the direct detection of small molecules. [Doctoral Dissertation]. University of Iowa; 2013. Available from: https://ir.uiowa.edu/etd/5042

Universitat Politècnica de Catalunya

29. Ivanova, Kristina Dimitrova. Nanostructured coatings for controlling bacterial biofilms and antibiotic resistance.

Degree: Departament d'Enginyeria Química, 2017, Universitat Politècnica de Catalunya

URL: http://hdl.handle.net/10803/405631

► La rápida aparición de bacterias resistentes a fármacos es uno de los problemas más graves del sistema sanitario convirtiéndose en un gran reto encontrar nuevos… (more)

▼ La rápida aparición de bacterias resistentes a fármacos es uno de los problemas más graves del sistema sanitario convirtiéndose en un gran reto encontrar nuevos antibióticos. Para superar la acción de los antibióticos, las bacterias utilizan diferentes mecanismos de resistencia incluyendo la formación de biopelículas. Las biopelículas son comunidades complejas de células bacterianas unidas por una matriz polimérica comúnmente encontradas en dispositivos médicos invasivos como los catéteres urinarios. Cuando los patógenos adoptan este modo de crecimiento en superficies, evitan eficazmente las defensas inmunitarias y el efecto de los antibióticos, causando infecciones. Esta tesis se centra en el desarrollo de nuevos materiales y recubrimientos nanoestructurados para el control de biopelículas bacterianas y la reducción de su resistencia a antibióticos. Por lo tanto, las enzimas acilasa y amilasa, capaces de degradar los componentes necesarios de las bacterias para formar biopelículas, se combinaron de forma innovadora en nanorecubrimientos híbridos para intervenir en el crecimiento de las biopelículas en dispositivos médicos permanentes. Además, la transformación de agentes antimicrobianos a forma "nano" se utilizó para mejorar su eficacia antibacteriana y superarlos mecanismos de resistencia a fármacos de las bacterias. Estas estrategias ofrecen nuevas perspectivas para el tratamiento de las infecciones relacionadas con biopelículas, limitando la selección y propagación de la resistencia bacteriana. La primera parte de la tesis describe la generación de recubrimientos multicapa de enzimas capaces de interferir con el sistema de comunicación bacteriana, denominado quórum sensing (QS) y prevenir la formación de biopelículas en el superficie de los catéteres urinarios. Esto se consiguió por deposición alternada de acilasa, cargada negativamente, y polietilenimina, cargada de manera opuesta, en la forma de capa a capa (LbL). Los catéteres recubiertos con acilasa inhibieron el proceso QS de bacterias Gram-negativas y redujeron significativamente el crecimiento de biopelículas en los catéteres urinarios en condiciones que imitaban la situación real en pacientes cateterizados. Adicionalmente, la acilasa se combinó con la enzima amilasa en recubrimientos híbridos capaces de interferir con las señales de comunicación entre bacterias y la integridad de la matriz de la biopelícula. El ensamblaje de las dos enzimas en recubrimientos híbridos dio lugar a una inhibición de la formación de biopelículas más fuerte en función de la localización de la acilasa o de la amilasa en la multicapa. Nanorecubrimientos con acilasa en la capa más externa redujo la formación de biopelículas en catéteres de silicona in vitro y en un modelo animal in vivo. La tesis también muestra la eficacia de nanomateriales para el control de biopelículas bacterianas. Las nanoesferas (NSs) antibacterianas, que contienen en su estructura multicapas ensambladas que se liberan bajo demanda, fueron depositados sobre silicona. Aminocelulosa (AC) se transformó primero… Advisors/Committee Members: [email protected] (authoremail), false (authoremailshow), Tzanov, Tzanko (director), true (authorsendemail).

Subjects/Keywords: Enzymes; Layer-by-Layer coatings; Sonochemistry; Nanospheres; Urinary catheters; Quorum quenching; Antibacterial activity; Biofilm prevention; Antibiotic resistance; Àrees temàtiques de la UPC::Enginyeria química; 66

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ivanova, K. D. (2017). Nanostructured coatings for controlling bacterial biofilms and antibiotic resistance. (Thesis). Universitat Politècnica de Catalunya. Retrieved from http://hdl.handle.net/10803/405631

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ivanova, Kristina Dimitrova. “Nanostructured coatings for controlling bacterial biofilms and antibiotic resistance.” 2017. Thesis, Universitat Politècnica de Catalunya. Accessed January 18, 2021. http://hdl.handle.net/10803/405631.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ivanova, Kristina Dimitrova. “Nanostructured coatings for controlling bacterial biofilms and antibiotic resistance.” 2017. Web. 18 Jan 2021.

Vancouver:

Ivanova KD. Nanostructured coatings for controlling bacterial biofilms and antibiotic resistance. [Internet] [Thesis]. Universitat Politècnica de Catalunya; 2017. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10803/405631.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ivanova KD. Nanostructured coatings for controlling bacterial biofilms and antibiotic resistance. [Thesis]. Universitat Politècnica de Catalunya; 2017. Available from: http://hdl.handle.net/10803/405631

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Iowa State University

30. Lewis, Brian Wellington. Silica nanosphere textured back reflectors for increased absorption in thin film amorphous silicon solar cells.

Degree: 2010, Iowa State University

URL: https://lib.dr.iastate.edu/etd/11466

► Absorption of long-wavelength photons in thin-film hydrogenated amorphous silicon (a-Si:H) solar cells is inherently low due to an absorption layer thickness of 250-300nm and long… (more)

Subjects/Keywords: Back Reflectors; Nanoparticles; Nanospheres; Solar Cells; Electrical and Computer Engineering

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lewis, B. W. (2010). Silica nanosphere textured back reflectors for increased absorption in thin film amorphous silicon solar cells. (Thesis). Iowa State University. Retrieved from https://lib.dr.iastate.edu/etd/11466

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lewis, Brian Wellington. “Silica nanosphere textured back reflectors for increased absorption in thin film amorphous silicon solar cells.” 2010. Thesis, Iowa State University. Accessed January 18, 2021. https://lib.dr.iastate.edu/etd/11466.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lewis, Brian Wellington. “Silica nanosphere textured back reflectors for increased absorption in thin film amorphous silicon solar cells.” 2010. Web. 18 Jan 2021.

Vancouver:

Lewis BW. Silica nanosphere textured back reflectors for increased absorption in thin film amorphous silicon solar cells. [Internet] [Thesis]. Iowa State University; 2010. [cited 2021 Jan 18]. Available from: https://lib.dr.iastate.edu/etd/11466.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lewis BW. Silica nanosphere textured back reflectors for increased absorption in thin film amorphous silicon solar cells. [Thesis]. Iowa State University; 2010. Available from: https://lib.dr.iastate.edu/etd/11466

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

		in
And / Or
		in
And / Or
		in
And / Or
		in

Open Access Theses and Dissertations