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You searched for subject:(Nanoparticulates). One record found.

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1. Vangara, Ravi Sankar. Conception and evaluation of suppositories loaded nanoparticulates as drug delivery system.

Degree: Pharmaceutical Sciences, 2014, Jawaharlal Nehru Technological University, Anantapuram

Rectal drug delivery system are useful delivery system for various types of drugs with narrow therapeutic window of absorption, for the drugs with pH dependent solubility, drugs which degrade in the lower pH conditions, rectal delivery system can be achieved by rectal suppositories, ointments, creams, tablets. The present dissertation aimed in conception and evaluation of novel dosage of nanoparticles loaded suppositories. Initially aspirin-chitosan nanoparticles were prepared by ionic gelation method results has shown in a good correlation in the case of chitosan-Aspirin nanoparticles with increase in the particle size there is increase in the percentage drug entrapment of aspirin nanoparticles. Compatibility study performed using Fourier transformer infrared spectroscopy (FTIR) and Differential scanning calorimeter (DSC) between Aspirin and excipients used in the formulation and proved for no incompatibility issues. The process was optimized for process related parameters effect of chitosan concentration and STPP. Based on results the best formulation was selected and in order to know the diffusion efficiency different compositions of aspirin glycerogelatin suppositories were prepared and subjected to various in-vitro evaluation studies and best composition was selected, From the evaluation studies best formulation from aspirin nanoparticles incorporated in to selected glycerol gelatin bases and evaluated for in-vitro characteristics. The results indicates that formulation Fa9 and Fb9 Aspirin nanoparticles were proved to be best formulation with 88.3±1.1 and 75±1 % of drug release at the end of 24hr, with zero drug release. iv The drug release profile was best fitted to Krosmayer s Peppas equation, the n value of (release exponent) nanoparticles were present between (0.4815 to 0.6251) and (0.511 to 0.749) which is near to 0.5 indicates the drug release follows non-fickian diffusion model. When the values are fitted to zero order the regression value (0.9926 to 0.990) and (0.978 to 0.999) which is nearer to 1 indi

Summary and Conclusion p. 155-162, References 163 p. 189

Advisors/Committee Members: Dachinamoorthi D, Chandra Sekhar K B.

Subjects/Keywords: Nanoparticulates; Drug Delivery Systems; Pharmaceutical Sciences

Page 1

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Vangara, R. S. (2014). Conception and evaluation of suppositories loaded nanoparticulates as drug delivery system. (Thesis). Jawaharlal Nehru Technological University, Anantapuram. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/15801

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Vangara, Ravi Sankar. “Conception and evaluation of suppositories loaded nanoparticulates as drug delivery system.” 2014. Thesis, Jawaharlal Nehru Technological University, Anantapuram. Accessed June 15, 2019. http://shodhganga.inflibnet.ac.in/handle/10603/15801.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Vangara, Ravi Sankar. “Conception and evaluation of suppositories loaded nanoparticulates as drug delivery system.” 2014. Web. 15 Jun 2019.

Vancouver:

Vangara RS. Conception and evaluation of suppositories loaded nanoparticulates as drug delivery system. [Internet] [Thesis]. Jawaharlal Nehru Technological University, Anantapuram; 2014. [cited 2019 Jun 15]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15801.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vangara RS. Conception and evaluation of suppositories loaded nanoparticulates as drug delivery system. [Thesis]. Jawaharlal Nehru Technological University, Anantapuram; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15801

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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