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You searched for subject:(NTG). Showing records 1 – 3 of 3 total matches.

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University of Washington

1. Beal, Brennan. Comparing healthcare resource use and costs for patients with Normal Tension Glaucoma across levels of severity: a nationally representative sample of commercially insured US adults age 40 and older.

Degree: 2020, University of Washington

Introduction: Normal tension glaucoma (NTG) is a subset of open-angle glaucoma (OAG), which is the most prevalent form of glaucoma globally. Projections into 2040 predict a 74% increase to 111.8 million people affected worldwide. Though global burden of disease is increasing, little has been done to understand the burden of disease for patients with NTG regarding their annual healthcare resource utilization (HCRU) or costs and how disease severity may impact this burden. Objective: Our objective was to estimate the HCRU and costs for patients with NTG as well as their payers. We sought to understand if costs and HCRU depends on one’s severity of disease and whether or not laterality of disease modifies the effect of this relationship. Methods: Our study was a retrospective cohort study of 6,330 US patients, 40 years of age and older, within the IBM® MarketScan® Commercial and Medicare Supplemental databases. Patients were enrolled if they were 40 years or older and had two or more qualifying NTG diagnoses, with the first of the two qualifying diagnoses being the patients’ index date. Baseline demographic and clinical characteristics were assessed for a 12-month pre-index period. The follow up period was 12-months post-index. Our analysis was carried out for two cohorts – those with unilateral disease and those with bilateral disease. The relationship between severity and HCRU was analyzed by fitting a generalized linear model with a Poisson distribution and log link for office visits. We relaxed the Poisson assumption and modeled prescription counts with a negative binomial model and log link to account for overdispersion. Costs were modeled with a generalized linear model with a gamma distribution and a log link. Cost data were adjusted to 2019 dollars. Results: Patients with severe, bilateral disease, filled over two additional prescriptions annually (2.5, 95% CI [2.0, 3.1]) when compared to their mild counterparts and accounted for 111 (95% CI [83.5, 139.1]) extra days of supply of glaucoma medications. These patients face 121 (95% CI [87, 155]) more out-of-pocket (OOP), and payers an additional 348 (95% CI [207, 488]), than their counterparts with a mild diagnosis on an annual basis. Conclusion: Our results suggest that patient burden is higher for those with severe disease compared to those with mild NTG. The excess burden is not only attributed to additional HCRU, but also by a higher financial burden, which accompanies their higher resource use. Patients were not alone in harboring burden as payers experienced a much larger financial burden from patients with severe disease compared to those with mild NTG. Most of the cost differences can be attributed to additional prescription use. Advisors/Committee Members: Devine, Beth (advisor).

Subjects/Keywords: Cost; Glaucoma; NTG; Utilization; Health sciences; Economics; Biostatistics; Pharmaceutical sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Beal, B. (2020). Comparing healthcare resource use and costs for patients with Normal Tension Glaucoma across levels of severity: a nationally representative sample of commercially insured US adults age 40 and older. (Thesis). University of Washington. Retrieved from http://hdl.handle.net/1773/45756

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Beal, Brennan. “Comparing healthcare resource use and costs for patients with Normal Tension Glaucoma across levels of severity: a nationally representative sample of commercially insured US adults age 40 and older.” 2020. Thesis, University of Washington. Accessed September 23, 2020. http://hdl.handle.net/1773/45756.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Beal, Brennan. “Comparing healthcare resource use and costs for patients with Normal Tension Glaucoma across levels of severity: a nationally representative sample of commercially insured US adults age 40 and older.” 2020. Web. 23 Sep 2020.

Vancouver:

Beal B. Comparing healthcare resource use and costs for patients with Normal Tension Glaucoma across levels of severity: a nationally representative sample of commercially insured US adults age 40 and older. [Internet] [Thesis]. University of Washington; 2020. [cited 2020 Sep 23]. Available from: http://hdl.handle.net/1773/45756.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Beal B. Comparing healthcare resource use and costs for patients with Normal Tension Glaucoma across levels of severity: a nationally representative sample of commercially insured US adults age 40 and older. [Thesis]. University of Washington; 2020. Available from: http://hdl.handle.net/1773/45756

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Akaiwa, Kei. Edaravone suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma : Edaravoneによる正常眼圧緑内障モデルマウスの網膜神経節細胞死の抑制.

Degree: 博士(医学), 2018, Tokushima University / 徳島大学

Subjects/Keywords: edaravone; NTG; oxidative stress; EAAC1; free radical

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Akaiwa, K. (2018). Edaravone suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma : Edaravoneによる正常眼圧緑内障モデルマウスの網膜神経節細胞死の抑制. (Thesis). Tokushima University / 徳島大学. Retrieved from http://repo.lib.tokushima-u.ac.jp/111432

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Akaiwa, Kei. “Edaravone suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma : Edaravoneによる正常眼圧緑内障モデルマウスの網膜神経節細胞死の抑制.” 2018. Thesis, Tokushima University / 徳島大学. Accessed September 23, 2020. http://repo.lib.tokushima-u.ac.jp/111432.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Akaiwa, Kei. “Edaravone suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma : Edaravoneによる正常眼圧緑内障モデルマウスの網膜神経節細胞死の抑制.” 2018. Web. 23 Sep 2020.

Vancouver:

Akaiwa K. Edaravone suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma : Edaravoneによる正常眼圧緑内障モデルマウスの網膜神経節細胞死の抑制. [Internet] [Thesis]. Tokushima University / 徳島大学; 2018. [cited 2020 Sep 23]. Available from: http://repo.lib.tokushima-u.ac.jp/111432.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Akaiwa K. Edaravone suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma : Edaravoneによる正常眼圧緑内障モデルマウスの網膜神経節細胞死の抑制. [Thesis]. Tokushima University / 徳島大学; 2018. Available from: http://repo.lib.tokushima-u.ac.jp/111432

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Georgia Tech

3. Moon, Jongki. Mission-based guidance system design for autonomous UAVs.

Degree: PhD, Aerospace Engineering, 2009, Georgia Tech

The advantages of UAVs in the aviation arena have led to extensive research activities on autonomous technology of UAVs to achieve specific mission objectives. This thesis mainly focuses on the development of a mission-based guidance system. Among various missions expected of UAVs for future needs, autonomous formation flight (AFF) and obstacle avoidance within safe operation limits are investigated. In the design of an adaptive guidance system for AFF, the leader information except position is assumed to be unknown to a follower. Thus, the only measured information related to the leader is the line-of-sight range and angle. Adding an adaptive element with neural networks into the guidance system provides a capability to effectively handle leader's velocity changes. Therefore, this method can be applied to the AFF control systems that use passive sensing methods. The simulation and flight test results clearly show that the adaptive guidance control system is a promising solution for autonomous formation flight of UAVs. The successful flight evaluations using the GTMax rotary wing UAV also demonstrate unique maneuvering aspects associated with rotary wing UAVs in formation flight. In the design of an autonomous obstacle avoidance system, an integrated approach is proposed to resolve the conflict between aggressive maneuvering needed for obstacle avoidance and the constrained maneuvering needed for envelope protection. A time-optimal problem with obstacle and envelope constraints is used for an integrated approach for obstacle avoidance and envelope protection. The Nonlinear trajectory generator (NTG) is used as a real-time optimization solver. The computational complexity arising from the obstacle constraints is reduced by converting the obstacle constraints into a safe waypoint constraint along with an implicit requirement that the horizontal velocity during the avoidance maneuver must be non-negative. The issue of when to initiate a time-optimal avoidance maneuver is addressed by including a requirement that the vehicle must maintain its original flight path to the maximum extent possible. The simulation results using a rotary wing UAV demonstrate the feasibility of the proposed approach for obstacle avoidance with envelope protection. Advisors/Committee Members: Prasad, JVR (Committee Chair), Costello, Mark (Committee Member), Johnson, Eric (Committee Member), Schrage, Daniel (Committee Member), Vela, Patricio (Committee Member).

Subjects/Keywords: Obstacle avoidance; Envelope protection; Adptive control; Optimal control; NTG; UAV; Formation flight; Drone aircraft Control systems; Drone aircraft; Guidance systems (Flight)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Moon, J. (2009). Mission-based guidance system design for autonomous UAVs. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/31797

Chicago Manual of Style (16th Edition):

Moon, Jongki. “Mission-based guidance system design for autonomous UAVs.” 2009. Doctoral Dissertation, Georgia Tech. Accessed September 23, 2020. http://hdl.handle.net/1853/31797.

MLA Handbook (7th Edition):

Moon, Jongki. “Mission-based guidance system design for autonomous UAVs.” 2009. Web. 23 Sep 2020.

Vancouver:

Moon J. Mission-based guidance system design for autonomous UAVs. [Internet] [Doctoral dissertation]. Georgia Tech; 2009. [cited 2020 Sep 23]. Available from: http://hdl.handle.net/1853/31797.

Council of Science Editors:

Moon J. Mission-based guidance system design for autonomous UAVs. [Doctoral Dissertation]. Georgia Tech; 2009. Available from: http://hdl.handle.net/1853/31797

.