subject:(Myelin Sheath)

Rutgers University

1. Ayers, Brian Laurence, 1992-. Incorporating Schwann cells as a mediator of spinal cord outgrowth for regenerative therapies.

Degree: MS, Biomedical Engineering, 2020, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/64022/

► There are millions of individuals who are affected by motor disabilities and peripheral neuropathy in the USA due to autoimmune disease, onset from infection, and… (more)

Subjects/Keywords: Myelin sheath

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APA (6^th Edition):

Ayers, Brian Laurence, 1. (2020). Incorporating Schwann cells as a mediator of spinal cord outgrowth for regenerative therapies. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/64022/

Chicago Manual of Style (16^th Edition):

Ayers, Brian Laurence, 1992-. “Incorporating Schwann cells as a mediator of spinal cord outgrowth for regenerative therapies.” 2020. Masters Thesis, Rutgers University. Accessed March 07, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/64022/.

MLA Handbook (7^th Edition):

Ayers, Brian Laurence, 1992-. “Incorporating Schwann cells as a mediator of spinal cord outgrowth for regenerative therapies.” 2020. Web. 07 Mar 2021.

Vancouver:

Ayers, Brian Laurence 1. Incorporating Schwann cells as a mediator of spinal cord outgrowth for regenerative therapies. [Internet] [Masters thesis]. Rutgers University; 2020. [cited 2021 Mar 07]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/64022/.

Council of Science Editors:

Ayers, Brian Laurence 1. Incorporating Schwann cells as a mediator of spinal cord outgrowth for regenerative therapies. [Masters Thesis]. Rutgers University; 2020. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/64022/

Rutgers University

2. Yang, Po-Lung, 1977-. Molecular mechanisms regulating Schwann cell development and injury response in the PNS.

Degree: Biology, 2011, Rutgers University

URL: http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000063314

Subjects/Keywords: Myelin proteins; Demyelination; Myelin sheath—Diseases

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APA (6^th Edition):

Yang, Po-Lung, 1. (2011). Molecular mechanisms regulating Schwann cell development and injury response in the PNS. (Thesis). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000063314

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yang, Po-Lung, 1977-. “Molecular mechanisms regulating Schwann cell development and injury response in the PNS.” 2011. Thesis, Rutgers University. Accessed March 07, 2021. http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000063314.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yang, Po-Lung, 1977-. “Molecular mechanisms regulating Schwann cell development and injury response in the PNS.” 2011. Web. 07 Mar 2021.

Vancouver:

Yang, Po-Lung 1. Molecular mechanisms regulating Schwann cell development and injury response in the PNS. [Internet] [Thesis]. Rutgers University; 2011. [cited 2021 Mar 07]. Available from: http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000063314.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yang, Po-Lung 1. Molecular mechanisms regulating Schwann cell development and injury response in the PNS. [Thesis]. Rutgers University; 2011. Available from: http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000063314

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Stirling

3. Gillespie, Charles Stewart. Myelin membrane protein biosynthesis : an in vitro study.

Degree: PhD, 1988, University of Stirling

URL: http://hdl.handle.net/1893/22868

► The sites of biosynthesis and incorporation of the abundant CNS myelin proteins 2' , 3' -cyclic nucleotide-3'-phosphodiesterase (CNPase) and P2 protein into the growing myelin… (more)

▼ The sites of biosynthesis and incorporation of the abundant CNS myelin proteins 2' , 3' -cyclic nucleotide-3'-phosphodiesterase (CNPase) and P2 protein into the growing myelin membrane were investigated. Cell-free translation systems programmed with mRNA from rat brain, rabbit spinal cord, free and bound polysomes and purified myelin demonstrated conclusively that both CNPase and P2 are synthesized on free polysomes like the myelin basic proteins (MBPs) but unlike the proteolipid protein (PLP), the major intrinsic membrane protein of CNS myelin, which is known to be synthesized at the oligodendrocyte endoplasmic reticulum on bound polysomes (Colman et al., 1982) . These observations were supported by labelling studies on rats in vivo during the period of maximal myelin deposition. Newly synthesized CNPase associated with the myelin membrane very rapidly after labelling (~2 minutes) and this is consistent with the view that there is only a brief delay between synthesis and incorporation into their target membrane for extrinsic-type plasma membrane proteins. An RNA fraction isolated from purified CNS myelin was not enriched in mRNAs coding for CNPase and P2 but a considerable enrichment of mRNAs coding for MBPs was observed. This phenomenon has important implications for the cell biology of myelination since it suggests that although MBPs, CNPase and P2 are all basic extrinsic membrane proteins, and synthesized on free polysomes, different mechanisms for their transport to the myelin membrane exist. The addition of dog pancreatic microsomes (DPM) during translation showed no membrane association for CNPase however, at least 50% of MBPs were observed to non-specifically associate with these membranes. When newly synthesized MBP and P2 were incubated post-translationally with DPM or rabbit spinal cord myelin P2 only associated with myelin whereas MBP showed an equal affinity for both types of membranes. The segregation of MBP free polysomes at the myelin membrane during synthesis ensures that the nascent MBP polypeptides associate with the correct membrane. Recent evidence has shown that the free polysome-mRNA complex is bound to the cytoskeleton during protein synthesis. After extensive characterization of the purified rat brain oligodendrocyte and myelin-associated cytoskeletons it was shown that the synthesis of MBPs and CNPase only occurs from mRNA that is associated with the cytoskeleton and not when it is part of the cytoplasmic mRNA pool. Lipid analysis of the purified rat brain myelin-associated cytoskeleton revealed the presence of tightly bound lipid with a considerable enrichment of cerebroside and sphingomyelin (the latter at the expense of phosphatidylethanolamine). These studies on the cytoskeletal involvement in myelinogenesis suggest that extrinsic CNS myelin proteins are synthesized on the cytoskeleton and that post-translational cytoskeletal transport of these proteins to the growing myelin membrane may take place.

Subjects/Keywords: Myelin sheath; Proteins Synthesis

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APA (6^th Edition):

Gillespie, C. S. (1988). Myelin membrane protein biosynthesis : an in vitro study. (Doctoral Dissertation). University of Stirling. Retrieved from http://hdl.handle.net/1893/22868

Chicago Manual of Style (16^th Edition):

Gillespie, Charles Stewart. “Myelin membrane protein biosynthesis : an in vitro study.” 1988. Doctoral Dissertation, University of Stirling. Accessed March 07, 2021. http://hdl.handle.net/1893/22868.

MLA Handbook (7^th Edition):

Gillespie, Charles Stewart. “Myelin membrane protein biosynthesis : an in vitro study.” 1988. Web. 07 Mar 2021.

Vancouver:

Gillespie CS. Myelin membrane protein biosynthesis : an in vitro study. [Internet] [Doctoral dissertation]. University of Stirling; 1988. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1893/22868.

Council of Science Editors:

Gillespie CS. Myelin membrane protein biosynthesis : an in vitro study. [Doctoral Dissertation]. University of Stirling; 1988. Available from: http://hdl.handle.net/1893/22868

Dalhousie University

4. Martin, Erin. The behaviour of neurologic water during axonal and synaptic neurotransmission: An in silico study.

Degree: MS, Department of Chemistry, 2011, Dalhousie University

URL: http://hdl.handle.net/10222/14091

► Water is known to take on highly organized structures to influence the reactivity of chemical and biological systems; despite this, water is often only implicitly… (more)

Subjects/Keywords: Molecular dynamics; Car-Parrinello Molecular Dynamics; Myelin sheath; Gamma-aminobutyric acid; Acetylcholine; Water

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APA (6^th Edition):

Martin, E. (2011). The behaviour of neurologic water during axonal and synaptic neurotransmission: An in silico study. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/14091

Chicago Manual of Style (16^th Edition):

Martin, Erin. “The behaviour of neurologic water during axonal and synaptic neurotransmission: An in silico study.” 2011. Masters Thesis, Dalhousie University. Accessed March 07, 2021. http://hdl.handle.net/10222/14091.

MLA Handbook (7^th Edition):

Martin, Erin. “The behaviour of neurologic water during axonal and synaptic neurotransmission: An in silico study.” 2011. Web. 07 Mar 2021.

Vancouver:

Martin E. The behaviour of neurologic water during axonal and synaptic neurotransmission: An in silico study. [Internet] [Masters thesis]. Dalhousie University; 2011. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10222/14091.

Council of Science Editors:

Martin E. The behaviour of neurologic water during axonal and synaptic neurotransmission: An in silico study. [Masters Thesis]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/14091

University of Texas Southwestern Medical Center

5. He, Danyang. Epigenetic Regulation of Oligodendrocyte Development and Regeneration in the Central Nervous System.

Degree: 2016, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/6142

► Oligodendrocytes (OLs) produce myelin sheaths that electrically insulate axons and promote rapid propagation of action potentials in the CNS. The onset and timing of CNS… (more)

▼ Oligodendrocytes (OLs) produce myelin sheaths that electrically insulate axons and promote rapid propagation of action potentials in the CNS. The onset and timing of CNS myelination and remyelination requires precise coordination between epigenetic programming and transcriptional regulation. In this thesis, I present my findings on two epigenetic regulatory complexes Chd7/Sox10 and lncOL1/Suz12 in CNS myelination and remyelination. First, we show that chromatin remodeler Chd7 is required for proper onset of CNS myelination and remyelination. Genome-occupancy analyses, coupled with transcriptome profiling, reveal that Chd7 interacts with Sox10 and targets the enhancers of key myelinogenic genes, and identify novel Chd7 targets including bone formation regulators Osterix/Sp7 and Creb3l2, which are also critical for oligodendrocyte maturation. Thus, Chd7 coordinates with Sox10 to regulate the initiation of myelinogenesis and acts as a molecular nexus of regulatory networks that account for the development of a seemingly diverse array of lineages including oligodendrocytes and osteoblasts, pointing to the hitherto previously uncharacterized Chd7 functions in white matter pathogenesis in CHARGE syndrome. To understand the role of lncRNAs in CNS myelination, we establish dynamic expression profiles of lncRNAs at different stages of oligodendrocyte development and uncover a cohort of stage-specific oligodendrocyte-restricted lncRNAs including a conserved chromatinassociated lncOL1. Genetic inactivation of lncOL1 causes defects in CNS myelination and remyelination following injury. Functional analyses illustrate that lncOL1 interacts with Suz12, a component of PRC2, to promote oligodendrocyte maturation in part through Suz12-mediated repression of a differentiation inhibitory network that maintains the precursor state. Collectively, these studies show that epigenetic circuitry between lncRNAs and transcription factors with chromatin-modifying complexes play roles in balancing inhibitory and activating gene program, allowing the timely CNS myelination and myelin repair. Advisors/Committee Members: Kraus, W. Lee, Lu, Q. Richard, Johnson, Jane E., Olson, Eric N..

Subjects/Keywords: Gene Expression Regulation, Developmental; Myelin Sheath; Oligodendroglia; RNA, Long Noncoding; Transcription Factors

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APA (6^th Edition):

He, D. (2016). Epigenetic Regulation of Oligodendrocyte Development and Regeneration in the Central Nervous System. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/6142

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

He, Danyang. “Epigenetic Regulation of Oligodendrocyte Development and Regeneration in the Central Nervous System.” 2016. Thesis, University of Texas Southwestern Medical Center. Accessed March 07, 2021. http://hdl.handle.net/2152.5/6142.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

He, Danyang. “Epigenetic Regulation of Oligodendrocyte Development and Regeneration in the Central Nervous System.” 2016. Web. 07 Mar 2021.

Vancouver:

He D. Epigenetic Regulation of Oligodendrocyte Development and Regeneration in the Central Nervous System. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2016. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/2152.5/6142.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

He D. Epigenetic Regulation of Oligodendrocyte Development and Regeneration in the Central Nervous System. [Thesis]. University of Texas Southwestern Medical Center; 2016. Available from: http://hdl.handle.net/2152.5/6142

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

6. Cai, Zhao. A technique for examining longitudinal and cross sections of teased nerve fibres and its application to human and experimental neuropathy / a thesis submitted by Zhao Cai.

Degree: 2002, University of Adelaide

URL: http://hdl.handle.net/2440/21761

► A new method is described that enables longitudinal and cross sections of an individual nerve fibre to be cut at multiple specified sites along the… (more)

Subjects/Keywords: Myelinated neurofibrils; Myelin sheath Diseases Diagnosis.

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APA (6^th Edition):

Cai, Z. (2002). A technique for examining longitudinal and cross sections of teased nerve fibres and its application to human and experimental neuropathy / a thesis submitted by Zhao Cai. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/21761

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cai, Zhao. “A technique for examining longitudinal and cross sections of teased nerve fibres and its application to human and experimental neuropathy / a thesis submitted by Zhao Cai.” 2002. Thesis, University of Adelaide. Accessed March 07, 2021. http://hdl.handle.net/2440/21761.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cai, Zhao. “A technique for examining longitudinal and cross sections of teased nerve fibres and its application to human and experimental neuropathy / a thesis submitted by Zhao Cai.” 2002. Web. 07 Mar 2021.

Vancouver:

Cai Z. A technique for examining longitudinal and cross sections of teased nerve fibres and its application to human and experimental neuropathy / a thesis submitted by Zhao Cai. [Internet] [Thesis]. University of Adelaide; 2002. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/2440/21761.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cai Z. A technique for examining longitudinal and cross sections of teased nerve fibres and its application to human and experimental neuropathy / a thesis submitted by Zhao Cai. [Thesis]. University of Adelaide; 2002. Available from: http://hdl.handle.net/2440/21761

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

7. Boumah, Christine Eliane. Studies on the human myelin basic protein gene.

Degree: PhD, Faculty of Medicine, 1989, University of Alberta

URL: https://era.library.ualberta.ca/files/g445cg79t

Subjects/Keywords: Multiple sclerosis – Genetic aspects.; Molecular cloning.; Myelin sheath – Diseases.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Boumah, C. E. (1989). Studies on the human myelin basic protein gene. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/g445cg79t

Chicago Manual of Style (16^th Edition):

Boumah, Christine Eliane. “Studies on the human myelin basic protein gene.” 1989. Doctoral Dissertation, University of Alberta. Accessed March 07, 2021. https://era.library.ualberta.ca/files/g445cg79t.

MLA Handbook (7^th Edition):

Boumah, Christine Eliane. “Studies on the human myelin basic protein gene.” 1989. Web. 07 Mar 2021.

Vancouver:

Boumah CE. Studies on the human myelin basic protein gene. [Internet] [Doctoral dissertation]. University of Alberta; 1989. [cited 2021 Mar 07]. Available from: https://era.library.ualberta.ca/files/g445cg79t.

Council of Science Editors:

Boumah CE. Studies on the human myelin basic protein gene. [Doctoral Dissertation]. University of Alberta; 1989. Available from: https://era.library.ualberta.ca/files/g445cg79t

8. Krustev, Stefan / Кръстев, Стефан. Effect of the Myelin Sheath Aqueous Layers on the Membrane Properties of Simulated Demyelinating Neuropathies (Case Studies) /// Изследване ефекта на течните слоеве в миелиновата обвивка върху мембранните свойства на симулирани случаи на демиелинизиращи невропатии.

Degree: 2011, Medical University of Varna

URL: http://repository.mu-varna.bg/handle/nls/267

► [EN] Studies of natural myelin demonstrate that myelin lamellae are separated by aqueous layers. To expand our understanding of the mechanisms governing the clinical distortion… (more)

▼ [EN] Studies of natural myelin demonstrate that myelin lamellae are separated by aqueous layers. To expand our understanding of the mechanisms governing the clinical distortion of the properties of nerve excitability in patients with demyelinating neuropathies, such as Charcot-Marie-Tooth disease type 1A (CMT1A) disorder and Chronic inflammatory demyelinating polyneuropathy (CIDP), we investigated the effect of myelin sheath aqueous layers on complex membrane properties of demyelination simulated nerve fibre. Multilamellar model of human motor fibre is used for the study of membrane properties such as action potential and electrotonic potential, duration and the power values of time constants, REO basis and cycles of recovery. They are calculated and compared under simulated normal case and in three types of progressively greater demyelinations (i. e. internodal systematic demyelinations (ISDs) as specific indicators of CMT1A; paranodal systematic demyelination (PSD) and paranodal internodal systematic demyelination (PISD) - specific indicators, respectively, of CIDP and certain CIDP subtypes with/ without aqueous layers. The results show that the aqueous layers effect on the properties of the nerve excitability in patients with CMT1A and CIDP depends on the type of demyelination. Some membrane properties degrade in simulated disease CMT1A, when myelin lamellae and their respective aqueous layers are reduced. However, any membrane parameters are improved in simulated CIDP aqueous layers. Aqueous layers do not modify membrane properties in simulated subtypes CIDP. The aqueous layers opposing effects on these properties are neutralized in cases of mixed demyelinations. ////////// ////////// [BG] Изследвания на естествения миелин показват, че миелиновите ламели са разделени от течни слоеве. За разширяване на познанието ни върху механизмите, обуславящи клиничното нарушаване на свойствата на нервната възбудимост при пациенти с демиелинизиращи невропатии като заболяването на Шарко-Мари-Туут тип 1А (CMT1A) и хронична възпалителна демиелинизираща полиневропатия (CIDP), тук е изследван ефектът на течните слоеве в миелиновата обвивка върху комплексни мембранни свойства на демиелинизации на симулирано нервно влакно. Мултиламеларен модел на човешко моторно влакно е използван за изследване на мембранните свойства, като потенциали (акционни, електротонични), сила продължителност времеви константи, реобази и цикли на възстановяване. Те са изчислени и сравнени при симулирани нормален случай и при три типа на прогресивно по-големи демиелинизации като интернодални системни демиелинизации (ISDs) - специфични индикатори на CMT1A; патанодални системни демиелинизации (PSDs) и паранодални интернодални системни демиелинизации (PISDs) - специфични индикатори, съответно на CIDP и на някои подтипове CIDP без/с течни слоеве. Резултатите показват, че ефектът на течните слоеве върху свойствата на нервната възбудимост при пациенти с CMT1A и CIDP зависи от типа на демиелинизацията. Някои от мембранните свойства са влошени при симулираното…

Subjects/Keywords: Myelin sheath aqueous layers; demyelinating neuropathies; nerve excitability; membrane properties; multilamellar model; Физика и биофизика / Physics and Biophysics

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APA (6^th Edition):

Krustev, Stefan / Кръстев, �. (2011). Effect of the Myelin Sheath Aqueous Layers on the Membrane Properties of Simulated Demyelinating Neuropathies (Case Studies) /// Изследване ефекта на течните слоеве в миелиновата обвивка върху мембранните свойства на симулирани случаи на демиелинизиращи невропатии. (Thesis). Medical University of Varna. Retrieved from http://repository.mu-varna.bg/handle/nls/267

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Krustev, Stefan / Кръстев, Стефан. “Effect of the Myelin Sheath Aqueous Layers on the Membrane Properties of Simulated Demyelinating Neuropathies (Case Studies) /// Изследване ефекта на течните слоеве в миелиновата обвивка върху мембранните свойства на симулирани случаи на демиелинизиращи невропатии.” 2011. Thesis, Medical University of Varna. Accessed March 07, 2021. http://repository.mu-varna.bg/handle/nls/267.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Krustev, Stefan / Кръстев, Стефан. “Effect of the Myelin Sheath Aqueous Layers on the Membrane Properties of Simulated Demyelinating Neuropathies (Case Studies) /// Изследване ефекта на течните слоеве в миелиновата обвивка върху мембранните свойства на симулирани случаи на демиелинизиращи невропатии.” 2011. Web. 07 Mar 2021.

Vancouver:

Krustev, Stefan / Кръстев �. Effect of the Myelin Sheath Aqueous Layers on the Membrane Properties of Simulated Demyelinating Neuropathies (Case Studies) /// Изследване ефекта на течните слоеве в миелиновата обвивка върху мембранните свойства на симулирани случаи на демиелинизиращи невропатии. [Internet] [Thesis]. Medical University of Varna; 2011. [cited 2021 Mar 07]. Available from: http://repository.mu-varna.bg/handle/nls/267.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Krustev, Stefan / Кръстев �. Effect of the Myelin Sheath Aqueous Layers on the Membrane Properties of Simulated Demyelinating Neuropathies (Case Studies) /// Изследване ефекта на течните слоеве в миелиновата обвивка върху мембранните свойства на симулирани случаи на демиелинизиращи невропатии. [Thesis]. Medical University of Varna; 2011. Available from: http://repository.mu-varna.bg/handle/nls/267

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universitat de Barcelona

9. Soriano Raya, Juan José. MRI and neuropsychological correlates of white matter hyperintensities in asymptomatic subjects aged 50 to 65 years.

Degree: Departament de Psiquiatria i Psicobiologia Clínica, 2016, Universitat de Barcelona

URL: http://hdl.handle.net/10803/396266

► En las últimas tres décadas, la evidencia científica sobre las repercusiones clínicas de las hiperintensidades de sustancia blanca cerebral (HSBC) ha sido numerosa. En la… (more)

Subjects/Keywords: Mielina; Myelin sheath; Malalties cerebrovasculars; Enfermedades cerebrovasculares; Cerebrovascular disease; Neuropsicologia; Neuropsicología; Neuropsychology; Ciències de la Salut; 616.89

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APA (6^th Edition):

Soriano Raya, J. J. (2016). MRI and neuropsychological correlates of white matter hyperintensities in asymptomatic subjects aged 50 to 65 years. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/396266

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Soriano Raya, Juan José. “MRI and neuropsychological correlates of white matter hyperintensities in asymptomatic subjects aged 50 to 65 years.” 2016. Thesis, Universitat de Barcelona. Accessed March 07, 2021. http://hdl.handle.net/10803/396266.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Soriano Raya, Juan José. “MRI and neuropsychological correlates of white matter hyperintensities in asymptomatic subjects aged 50 to 65 years.” 2016. Web. 07 Mar 2021.

Vancouver:

Soriano Raya JJ. MRI and neuropsychological correlates of white matter hyperintensities in asymptomatic subjects aged 50 to 65 years. [Internet] [Thesis]. Universitat de Barcelona; 2016. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10803/396266.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Soriano Raya JJ. MRI and neuropsychological correlates of white matter hyperintensities in asymptomatic subjects aged 50 to 65 years. [Thesis]. Universitat de Barcelona; 2016. Available from: http://hdl.handle.net/10803/396266

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universitat de Barcelona

10. Arnedo Llena, Tanit. Paper del canal de clorur CIC-2 en les patologies de la mielina.

Degree: Departament de Ciències Fisiològiques II, 2015, Universitat de Barcelona

URL: http://hdl.handle.net/10803/310220

► Megalencephalic Leukoencephalopathy with subcortical Cysts (MLC) is a rare type of vacuolating leukodystrophy. Currently still unknown pathophysiological mechanism of the disease, and therefore there is… (more)

▼ Megalencephalic Leukoencephalopathy with subcortical Cysts (MLC) is a rare type of vacuolating leukodystrophy. Currently still unknown pathophysiological mechanism of the disease, and therefore there is no effective treatment possible for patients. There are two genes involved in the MLC disease. Gene was first discovered was MLC1 and this encodes for a membrane protein with the same name. The second gene is called GLIALCAM and encodes for a transmembrane protein type I that also carries the same name. In our group is has been described that GlialCAM acts as a protein ß subunit of MLC1 because it is able to direct and concentrate in the cellular junctions. Moreover, GlialCAM also act as auxiliary subunit of CLC-2 Cl channel as it is capable of modifying the activation and rectification properties of the channel. Recently, mutations in ClC-2 have been associated with a rare type of vacuolating leukodystrophy. The principal aim of this study is to advance in the knowledge of GlialCAM and ClC-2 in the glial cells and into the pathogenesis of vacuolating leukodistrophies. To accomplish the study, the group performed a biochemical and funcional characterization of new mutations in GLIALCAM associated with MLC. We suggest that the HEPACAM mutations described up to now can be classified in several groups. Some mutations can affect GlialCAM protein expression, affect its ability to cis-homooligomerize and consequently reduce their localization in cell–cell junctions. Some mutations can affect specifically only transinteractions between GlialCAM molecules or may be unstable without MLC1 and finally some mutations affect the protein internalization. Parallel progress was made in the biochemical relationship between GlialCAM and ClC-2 from biochemical and functional studies of mutations in CLCN2 associated with vacuolating leukodystrophies. GlialCAM has been observed to increase ClC-2 function by the modification of its gating and the stabilization of ClC-2 in the plasma membrane. In addition, the stabilization requires a previous formation of GlialCAM’s homocomplexes. Finally, a knock-down model of the CLC-2 protein was generated and characterized to deepen the role of CLC -2 astrocytes. As well as progress was made in biochemistry and functional relationship between CLC -2 and GlialCAM in the astrocitic physiology. It has been reported that astrocytes cultured in conditions of high concentrations of K + , similar to what happens in situations of high neuronal activity , CLC -2 translocates from the Golgi apparatus to the cell membrane , changing the its functional properties for the purpose of GlialCAM . However, in MLC1 deficient astrocytes, CLC -2 is retained intracellularly. This would indicate that these proteins could play a role in the potassium siphoning, and therefore the relocation of CLC -2 could lead to disorder in the homeostasis of water and ions. Advisors/Committee Members: [email protected] (authoremail), false (authoremailshow), Estévez Povedano, Raúl (director), Estévez Povedano, Raúl (tutor), true (authorsendemail).

Subjects/Keywords: Malalties neurodegeneratives; Enfermedades neurodegenerativas; Neurodegenerative Diseases; Mielina; Myelin sheath; Astròcits; Astrocitos; Astrocytes; Leucodistròfia; Leucodistrofia; Leukodystrophy; Ciències de la Salut; 612

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APA (6^th Edition):

Arnedo Llena, T. (2015). Paper del canal de clorur CIC-2 en les patologies de la mielina. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/310220

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Arnedo Llena, Tanit. “Paper del canal de clorur CIC-2 en les patologies de la mielina.” 2015. Thesis, Universitat de Barcelona. Accessed March 07, 2021. http://hdl.handle.net/10803/310220.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Arnedo Llena, Tanit. “Paper del canal de clorur CIC-2 en les patologies de la mielina.” 2015. Web. 07 Mar 2021.

Vancouver:

Arnedo Llena T. Paper del canal de clorur CIC-2 en les patologies de la mielina. [Internet] [Thesis]. Universitat de Barcelona; 2015. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10803/310220.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arnedo Llena T. Paper del canal de clorur CIC-2 en les patologies de la mielina. [Thesis]. Universitat de Barcelona; 2015. Available from: http://hdl.handle.net/10803/310220

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Gothenburg / Göteborgs Universitet

11. Corneliuson, Olle, 1954-. Structural and biochemical studies on marchi-positive myelinoid bodies in the central nervous system.

Degree: 1988, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/17421

Subjects/Keywords: Nervsystemet Neurologi Brain: cytology; Myelin sheath: cytology

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APA (6^th Edition):

Corneliuson, Olle, 1. (1988). Structural and biochemical studies on marchi-positive myelinoid bodies in the central nervous system. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/17421

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Corneliuson, Olle, 1954-. “Structural and biochemical studies on marchi-positive myelinoid bodies in the central nervous system.” 1988. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed March 07, 2021. http://hdl.handle.net/2077/17421.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Corneliuson, Olle, 1954-. “Structural and biochemical studies on marchi-positive myelinoid bodies in the central nervous system.” 1988. Web. 07 Mar 2021.

Vancouver:

Corneliuson, Olle 1. Structural and biochemical studies on marchi-positive myelinoid bodies in the central nervous system. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 1988. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/2077/17421.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Corneliuson, Olle 1. Structural and biochemical studies on marchi-positive myelinoid bodies in the central nervous system. [Thesis]. University of Gothenburg / Göteborgs Universitet; 1988. Available from: http://hdl.handle.net/2077/17421

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. Ho, Alex Tsung-Lin. Myelination in the developing chicken ciliary ganglion.

Degree: PhD, 2003, Oregon Health Sciences University

URL: doi:10.6083/M4TD9VNP ; http://digitalcommons.ohsu.edu/etd/3136

Subjects/Keywords: Myelin Sheath; Ciliary Body – innervation; Neuregulins; Schwann Cells; Chick Embryo; Chickens

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APA (6^th Edition):

Ho, A. T. (2003). Myelination in the developing chicken ciliary ganglion. (Doctoral Dissertation). Oregon Health Sciences University. Retrieved from doi:10.6083/M4TD9VNP ; http://digitalcommons.ohsu.edu/etd/3136

Chicago Manual of Style (16^th Edition):

Ho, Alex Tsung-Lin. “Myelination in the developing chicken ciliary ganglion.” 2003. Doctoral Dissertation, Oregon Health Sciences University. Accessed March 07, 2021. doi:10.6083/M4TD9VNP ; http://digitalcommons.ohsu.edu/etd/3136.

MLA Handbook (7^th Edition):

Ho, Alex Tsung-Lin. “Myelination in the developing chicken ciliary ganglion.” 2003. Web. 07 Mar 2021.

Vancouver:

Ho AT. Myelination in the developing chicken ciliary ganglion. [Internet] [Doctoral dissertation]. Oregon Health Sciences University; 2003. [cited 2021 Mar 07]. Available from: doi:10.6083/M4TD9VNP ; http://digitalcommons.ohsu.edu/etd/3136.

Council of Science Editors:

Ho AT. Myelination in the developing chicken ciliary ganglion. [Doctoral Dissertation]. Oregon Health Sciences University; 2003. Available from: doi:10.6083/M4TD9VNP ; http://digitalcommons.ohsu.edu/etd/3136

13. Rimkus, Carolina de Medeiros. As características microestruturais do tecido neural e o grau de atrofia cerebral nos estágios iniciais da esclerose múltipla remitente-recorrente.

Degree: PhD, Radiologia, 2013, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5151/tde-10052013-121043/ ;

► Introdução: Os processos degenerativos vêm sendo considerados determinantes da progressão do déficit neurológico na esclerose múltipla (EM) e são associados sobretudo à perda neuronal e… (more)

▼ Introdução: Os processos degenerativos vêm sendo considerados determinantes da progressão do déficit neurológico na esclerose múltipla (EM) e são associados sobretudo à perda neuronal e axonal. A patologia na substância branca (SB) manifesta-se pela quebra de membranas e perda da complexidade microestrutural dos tratos cerebrais, o que pode ser estudado indiretamente pelas alterações nos índices de fração de anisotropia (FA) e difusividade média (DM), obtidos por meio das análises das imagens por tensores de difusão (diffusion tensor imaging - DTI). Essa técnica oferece outros dois índices mais específicos, a difusividade axial () e difusividade radial (), que são associados aos processos de perda axonal e desmielinização, respectivamente. A perda neuronal na substância cinzenta (SC) pode ser avaliada pelo grau de atrofia do córtex cerebral. Este estudo tem como objetivos mensurar os índices de DTI na maior comissura cerebral, o corpo caloso (CC), e o grau e distribuição da atrofia cortical em indivíduos com EM remitente-recorrente (EMRR) e baixos escores de incapacidade funcional, correlacionando essas alterações com o volume de lesões macroscópicas e os principais parâmetros clínicos. Método: 31 indivíduos (22 mulheres, idade média 30,5 anos ± 8,7) com EMRR e um grupo controle (GC) composto por 34 indivíduos saudáveis (27 mulheres, idade média 32,3 anos ± 7,8) realizaram exames de crânio em aparelho de ressonância magnética de 3 Tesla (3T), sendo adquiridas imagens de DTI com 32 direções de gradiente, obtendo-se os índices de FA, DM, e de cinco segmentos na secção sagital do corpo caloso (CC). Através da segmentação de imagens volumétricas ponderadas em T1 foram obtidas as espessuras corticais regionais nos grupos. Esses resultados foram correlacionados com os volumes lesionais de imagens ponderadas em T1 e T2/FLAIR e os escores da escala expandida do estado de incapacidade (Expanded Disability Status Scale - EDSS), considerando-se significativos resultados com p< 0,05. Resultados: Os índices de FA, DM e do CC estavam difusamente alterados no grupo EMRR e a , alterada significativamente no esplênio, tronco médio anterior e tronco médio posterior do CC. Observou-se atrofia cortical significativa no terço anterior dos lobos temporais, bilateralmente, e nas regiões parietal inferior, insular e fronto-orbitária direitas, com uma tendência à atrofia no giro frontal superior esquerdo. As FA, DM e correlacionaram-se com os volumes lesionais T1 e, mais significativamente, com os volumes lesionais T2/FLAIR, porém não houve correlação entre os volumes lesionais e a . A espessura cortical no grupo EMRR apresentou correlações com ambos os volumes lesionais, mais significativamente com as lesões em T1. O escore médio da EDSS era 1,1 ± 0,9 (variando de 0-3), apresentando correlações com a DM e a no esplênio, tronco médio anterior e posterior do CC, com uma correlação com a no tronco médio posterior. O EDSS correlacionou-se com a espessura cortical na topografia do giro frontal superior esquerdo. Discussão e conclusão:… Advisors/Committee Members: Leite, Claudia da Costa, Otaduy, Maria Concepcion Garcia.

Subjects/Keywords: Bainha de mielina; Degeneração neural; Diffusion tensor imaging; Esclerose múltipla; Imagem de tensor de difusão; Imagem por ressonância magnética; Magnetic resonance imaging; Multiple sclerosis; Myelin sheath; Nerve degeneration

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rimkus, C. d. M. (2013). As características microestruturais do tecido neural e o grau de atrofia cerebral nos estágios iniciais da esclerose múltipla remitente-recorrente. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5151/tde-10052013-121043/ ;

Chicago Manual of Style (16^th Edition):

Rimkus, Carolina de Medeiros. “As características microestruturais do tecido neural e o grau de atrofia cerebral nos estágios iniciais da esclerose múltipla remitente-recorrente.” 2013. Doctoral Dissertation, University of São Paulo. Accessed March 07, 2021. http://www.teses.usp.br/teses/disponiveis/5/5151/tde-10052013-121043/ ;.

MLA Handbook (7^th Edition):

Rimkus, Carolina de Medeiros. “As características microestruturais do tecido neural e o grau de atrofia cerebral nos estágios iniciais da esclerose múltipla remitente-recorrente.” 2013. Web. 07 Mar 2021.

Vancouver:

Rimkus CdM. As características microestruturais do tecido neural e o grau de atrofia cerebral nos estágios iniciais da esclerose múltipla remitente-recorrente. [Internet] [Doctoral dissertation]. University of São Paulo; 2013. [cited 2021 Mar 07]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5151/tde-10052013-121043/ ;.

Council of Science Editors:

Rimkus CdM. As características microestruturais do tecido neural e o grau de atrofia cerebral nos estágios iniciais da esclerose múltipla remitente-recorrente. [Doctoral Dissertation]. University of São Paulo; 2013. Available from: http://www.teses.usp.br/teses/disponiveis/5/5151/tde-10052013-121043/ ;

University of Oulu

14. Myllykoski, M. (Matti). Structure and function of the myelin enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase.

Degree: 2013, University of Oulu

URL: http://urn.fi/urn:isbn:9789526201375

►

Abstract The myelin sheath is a crucial component of vertebrate nervous systems. Myelin is formed as the plasma membrane of a glial cell is wrapped… (more)

▼

Abstract The myelin sheath is a crucial component of vertebrate nervous systems. Myelin is formed as the plasma membrane of a glial cell is wrapped around a neuronal axon. The presence of myelin enables the fast transmission of neuronal impulses, and degradation or dysfunction of myelin results in severe neurological symptoms. Molecular composition of myelin is unique, and many myelin proteins are not present elsewhere in the body. A myelin enzyme, 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase), is found in specific regions within the myelin sheath and is one of the most abundant proteins in the brain. Substrates for CNPase catalytic activity are formed during brain damage. CNPase also interacts with the cytoskeleton and cell membranes, and it is thought to play a role during myelin formation. Mice that lack CNPase suffer from axonal degeneration and die early. The aim of this study was to characterise CNPase structure and function. To this end, a system was first developed to produce the protein for subsequent analyses. The aim was to characterise the catalytic mechanism of CNPase by determining its three-dimensional molecular structure at different stages of the catalytic reaction. The interactions between CNPase and other molecules related to its function would also be characterised. Finally, the structure of the full-length protein would be used to understand of the function of the uncharacterised N-terminal domain. Using X-ray crystallography, the structure of the CNPase catalytic domain was determined in the presence of substrate and product molecules. These data, complemented with analyses of mutationally inactivated enzyme variants, were used to examine the catalytic reaction at the molecular level. The catalytic domain structure was compared to homologous enzymes from diverse organisms. The interaction between CNPase and the calcium-sensing protein calmodulin was characterised. The solution structure of full-length CNPase was determined using small-angle X-ray scattering, and protein sequence databases were utilised to determine CNPase conservation during animal evolution. The results provide novel information on the catalytic activity and overall function of CNPase. Further studies will be necessary to determine its specific role, but it is increasingly clear that CNPase can perform multiple important tasks within the nervous system.

Tiivistelmä Myeliinituppi on tärkeä osa selkärankaisten hermostoa. Myeliiniä muodostuu, kun gliasolun solukalvo kiertyy hermosolun aksonin ympärille. Myeliini mahdollistaa hermoimpulssien nopean välityksen, ja sen tuhoutuminen ja vajaatoiminta aiheuttavat vakavia neurologisia oireita. Myeliinin molekyylikoostumus on ainutlaatuinen, ja monet myeliiniproteiineista eivät esiinny muualla elimistössä. Myeliinissä esiintyvää entsyymiä, 2′,3′-syklisten nukleotidien 3′-fosfodiesteraasia (CNPaasi), esiintyy runsaasti tietyillä myeliinialueilla, ja se on yksi aivojen runsaslukuisimmista proteiineista. Substraatteja CNPaasin katalyyttiselle aktiivisuudelle muodostuu…

Advisors/Committee Members: Kursula, P. (Petri), Kursula, I. (Inari).

Subjects/Keywords: 2′,3′-cyclic nucleotide 3′-phosphodiesterase; X-ray crystallography; enzyme reaction mechanism; myelin sheath; nervous system; 2′,3′-syklisten nukleotidien 3′-fosfodiesteraasi; entsyymin reaktiomekanismi; hermosto; myeliinituppi; röntgensädekristallografia

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APA (6^th Edition):

Myllykoski, M. (. (2013). Structure and function of the myelin enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase. (Doctoral Dissertation). University of Oulu. Retrieved from http://urn.fi/urn:isbn:9789526201375

Chicago Manual of Style (16^th Edition):

Myllykoski, M (Matti). “Structure and function of the myelin enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase.” 2013. Doctoral Dissertation, University of Oulu. Accessed March 07, 2021. http://urn.fi/urn:isbn:9789526201375.

MLA Handbook (7^th Edition):

Myllykoski, M (Matti). “Structure and function of the myelin enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase.” 2013. Web. 07 Mar 2021.

Vancouver:

Myllykoski M(. Structure and function of the myelin enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase. [Internet] [Doctoral dissertation]. University of Oulu; 2013. [cited 2021 Mar 07]. Available from: http://urn.fi/urn:isbn:9789526201375.

Council of Science Editors:

Myllykoski M(. Structure and function of the myelin enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase. [Doctoral Dissertation]. University of Oulu; 2013. Available from: http://urn.fi/urn:isbn:9789526201375

15. Reginensi Espinoza, Diego. Modulación de las propiedades migratorias de las células de la glia envolvente.

Degree: 2015, Universitat de Barcelona

URL: http://hdl.handle.net/10803/296446

► Olfactory ensheathing cell transplantation emerged some years ago as a promising therapeutical strategy to repair injured spinal cord. However, inhibitory molecules are present for long… (more)

Subjects/Keywords: Biotecnologia; Biotecnología; Biotechnology; Regeneració del sistema nerviós; Regeneración del sistema nervioso; Nervous system regeneration; Neuròglia; Neuroglia; Mielina; Myelin sheath; Ciències Experimentals i Matemàtiques; 616.8

11 more images…

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APA (6^th Edition):

Reginensi Espinoza, D. (2015). Modulación de las propiedades migratorias de las células de la glia envolvente. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/296446

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Reginensi Espinoza, Diego. “Modulación de las propiedades migratorias de las células de la glia envolvente.” 2015. Thesis, Universitat de Barcelona. Accessed March 07, 2021. http://hdl.handle.net/10803/296446.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Reginensi Espinoza, Diego. “Modulación de las propiedades migratorias de las células de la glia envolvente.” 2015. Web. 07 Mar 2021.

Vancouver:

Reginensi Espinoza D. Modulación de las propiedades migratorias de las células de la glia envolvente. [Internet] [Thesis]. Universitat de Barcelona; 2015. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10803/296446.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Reginensi Espinoza D. Modulación de las propiedades migratorias de las células de la glia envolvente. [Thesis]. Universitat de Barcelona; 2015. Available from: http://hdl.handle.net/10803/296446

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universitat de Barcelona

16. Sirisi Dolcet, Sònia. Bases moleculars de la Leucoeocefalopatia Megalencefàllca amb Quists subcorlicals. Utilització de models animals i cel·lulars.

Degree: Departament de Ciències Fisiològiques II, 2014, Universitat de Barcelona

URL: http://hdl.handle.net/10803/284761

► Megalencefalic leukoencephalopathy with subcortical cysts, also known as MLC, is a rare type of leukodystrophy. Currently still unknown pathophysiological mechanism of the disease, and therefore… (more)

Subjects/Keywords: Malalties rares; Enfermedades raras; Rare diseases; Mielina; Myelin sheath; Malalties neurodegeneratives; Enfermedades neurodegeneratives; Neurodegenerative Diseases; Astròcits; Astrocitos; Astrocytes; Ciències de la Salut; 612

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APA (6^th Edition):

Sirisi Dolcet, S. (2014). Bases moleculars de la Leucoeocefalopatia Megalencefàllca amb Quists subcorlicals. Utilització de models animals i cel·lulars. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/284761

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sirisi Dolcet, Sònia. “Bases moleculars de la Leucoeocefalopatia Megalencefàllca amb Quists subcorlicals. Utilització de models animals i cel·lulars.” 2014. Thesis, Universitat de Barcelona. Accessed March 07, 2021. http://hdl.handle.net/10803/284761.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sirisi Dolcet, Sònia. “Bases moleculars de la Leucoeocefalopatia Megalencefàllca amb Quists subcorlicals. Utilització de models animals i cel·lulars.” 2014. Web. 07 Mar 2021.

Vancouver:

Sirisi Dolcet S. Bases moleculars de la Leucoeocefalopatia Megalencefàllca amb Quists subcorlicals. Utilització de models animals i cel·lulars. [Internet] [Thesis]. Universitat de Barcelona; 2014. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10803/284761.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sirisi Dolcet S. Bases moleculars de la Leucoeocefalopatia Megalencefàllca amb Quists subcorlicals. Utilització de models animals i cel·lulars. [Thesis]. Universitat de Barcelona; 2014. Available from: http://hdl.handle.net/10803/284761

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New South Wales

17. ONeill, John Hugh. Adaptation of the compact myelin sheath to a reduction in axonal size.

Degree: Medicine. Medicine, 1986, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/68653 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:69814/SOURCE01?view=true

Subjects/Keywords: Myelin sheath; Myelinated neurofibrils; Axons; Axons; Ataxia; Thesis Digitisation Program

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APA (6^th Edition):

ONeill, J. H. (1986). Adaptation of the compact myelin sheath to a reduction in axonal size. (Masters Thesis). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/68653 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:69814/SOURCE01?view=true

Chicago Manual of Style (16^th Edition):

ONeill, John Hugh. “Adaptation of the compact myelin sheath to a reduction in axonal size.” 1986. Masters Thesis, University of New South Wales. Accessed March 07, 2021. http://handle.unsw.edu.au/1959.4/68653 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:69814/SOURCE01?view=true.

MLA Handbook (7^th Edition):

ONeill, John Hugh. “Adaptation of the compact myelin sheath to a reduction in axonal size.” 1986. Web. 07 Mar 2021.

Vancouver:

ONeill JH. Adaptation of the compact myelin sheath to a reduction in axonal size. [Internet] [Masters thesis]. University of New South Wales; 1986. [cited 2021 Mar 07]. Available from: http://handle.unsw.edu.au/1959.4/68653 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:69814/SOURCE01?view=true.

Council of Science Editors:

ONeill JH. Adaptation of the compact myelin sheath to a reduction in axonal size. [Masters Thesis]. University of New South Wales; 1986. Available from: http://handle.unsw.edu.au/1959.4/68653 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:69814/SOURCE01?view=true

18. Kassler, Susannah W. Low molecular weight hyaluronic acid increases CD44 expression by oligodendrocytes and enhances inflammation.

Degree: MS, 2006, Oregon Health Sciences University

URL: doi:10.6083/M4QV3JS1 ; http://digitalcommons.ohsu.edu/etd/2889

Subjects/Keywords: Antigens, CD44; Hyaluronic Acid; Multiple Sclerosis – etiology; Oligodendroglia; T-Lymphocytes; Myelin Sheath; Encephalomyelitis, Autoimmune, Experimental

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APA (6^th Edition):

Kassler, S. W. (2006). Low molecular weight hyaluronic acid increases CD44 expression by oligodendrocytes and enhances inflammation. (Thesis). Oregon Health Sciences University. Retrieved from doi:10.6083/M4QV3JS1 ; http://digitalcommons.ohsu.edu/etd/2889

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kassler, Susannah W. “Low molecular weight hyaluronic acid increases CD44 expression by oligodendrocytes and enhances inflammation.” 2006. Thesis, Oregon Health Sciences University. Accessed March 07, 2021. doi:10.6083/M4QV3JS1 ; http://digitalcommons.ohsu.edu/etd/2889.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kassler, Susannah W. “Low molecular weight hyaluronic acid increases CD44 expression by oligodendrocytes and enhances inflammation.” 2006. Web. 07 Mar 2021.

Vancouver:

Kassler SW. Low molecular weight hyaluronic acid increases CD44 expression by oligodendrocytes and enhances inflammation. [Internet] [Thesis]. Oregon Health Sciences University; 2006. [cited 2021 Mar 07]. Available from: doi:10.6083/M4QV3JS1 ; http://digitalcommons.ohsu.edu/etd/2889.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kassler SW. Low molecular weight hyaluronic acid increases CD44 expression by oligodendrocytes and enhances inflammation. [Thesis]. Oregon Health Sciences University; 2006. Available from: doi:10.6083/M4QV3JS1 ; http://digitalcommons.ohsu.edu/etd/2889

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universitat de Barcelona

19. Santos Vives, Alicia. Estudio neuropsicológico, neurorradiológico y clínico en el hipercortisolismo endógeno = Neuropsychological, neuroradiological and clinical study in endogenous hypercortisolism.

Degree: 2015, Universitat de Barcelona

URL: http://hdl.handle.net/10803/384710

► El síndrome de Cushing endógeno es una enfermedad rara debida a un exceso de cortisol circulante. El exceso crónico de cortisol puede provocar una serie… (more)

▼ El síndrome de Cushing endógeno es una enfermedad rara debida a un exceso de cortisol circulante. El exceso crónico de cortisol puede provocar una serie de alteraciones que no en todos los casos revierten tras la curación hormonal, y que incluyen disminución del volumen cerebral, alteraciones neuropsicológicas y del estado de ánimo y riesgo cardiovascular elevado. Esta tesis pretende estudiar algunos de los efectos que provoca el síndrome de Cushing a nivel cerebral, analizando su relación con otros parámetros clínicos. Concretamente, los objetivos de la tesis incluyen por un lado analizar el volumen cerebelar en los pacientes con síndrome de Cushing, así como establecer su relación con el rendimiento neuropsicológico, los niveles de cortisol y otros parámetros clínicos. Por otro lado, se pretende analizar la presencia de lesiones de sustancia blanca cerebral en los pacientes con síndrome de Cushing y la relación entre riesgo cardiovascular, lesiones de sustancia blanca, rendimiento neuropsicológico y volumen cerebral. Se encontraron menores volúmenes del córtex cerebelar bilateral en los pacientes activos, pero no en los pacientes curados, en comparación con los controles. El córtex cerebelar correlacionó positivamente con el rendimiento en memoria visual y la calidad de vida y negativamente con la edad en el momento del diagnóstico y el nivel de triglicéridos circulantes. Los pacientes activos presentaban peor rendimiento a nivel de memoria, y ambos grupos de pacientes presentaban mayores niveles de ansiedad y depresión que los controles sanos. Por otro lado, los pacientes en remisión, pero no los pacientes activos presentaron mayor nivel de lesiones de sustancia blanca cerebral que los controles sanos. Estas lesiones estaban relacionadas con los niveles de tensión diastólica y la duración de la hipertensión. Los pacientes en remisión que tomaban hidrocortisona presentaban mayor nivel de lesiones que los pacientes en remisión que no tomaban el fármaco. Finalmente ambos grupos de pacientes (activos y en remisión) presentaban mayor riesgo cardiovascular que los controles sanos. El riesgo cardiovascular correlacionó negativamente con la función cognitiva y el volumen cerebral en los pacientes en remisión. En conclusión, el síndrome de Cushing determina diferentes comorbilidades en las distintas fases de la enfermedad. Algunas de las alteraciones halladas en los pacientes activos podrían ser al menos parcialmente reversibles, aunque el riesgo cardiovascular asociado a la enfermedad puede llevar a otras comorbilidades en el futuro si no se controla. Estos datos remarcan la importancia de proporcionar un soporte psicológico a los pacientes en caso necesario y de controlar el riesgo vascular para prevenir la posible afectación cerebral futura y reducir el riesgo de complicaciones cardiovasculares. Advisors/Committee Members: Universitat de Barcelona. Facultat de Psicologia, [email protected] (authoremail), false (authoremailshow), Webb, S. M. (Susan M.) (director), Mataró Serrat, Maria (director), Mataró Serrat, Maria (tutor), true (authorsendemail).

Subjects/Keywords: Neuropsicologia; Neuropsicología; Neuropsychology; Síndrome de Cushing; Cushing's syndrome; Mielina; Myelin sheath; Cerebel; Cerebelo; Cerebellum; Trastorns de la cognició; Trastornos cognitivos; Cognition disorders; Malalties cerebrals; Enfermedades cerebrales; Brain diseases; Ciències de la Salut; 159.9

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Santos Vives, A. (2015). Estudio neuropsicológico, neurorradiológico y clínico en el hipercortisolismo endógeno = Neuropsychological, neuroradiological and clinical study in endogenous hypercortisolism. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/384710

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Santos Vives, Alicia. “Estudio neuropsicológico, neurorradiológico y clínico en el hipercortisolismo endógeno = Neuropsychological, neuroradiological and clinical study in endogenous hypercortisolism.” 2015. Thesis, Universitat de Barcelona. Accessed March 07, 2021. http://hdl.handle.net/10803/384710.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Santos Vives, Alicia. “Estudio neuropsicológico, neurorradiológico y clínico en el hipercortisolismo endógeno = Neuropsychological, neuroradiological and clinical study in endogenous hypercortisolism.” 2015. Web. 07 Mar 2021.

Vancouver:

Santos Vives A. Estudio neuropsicológico, neurorradiológico y clínico en el hipercortisolismo endógeno = Neuropsychological, neuroradiological and clinical study in endogenous hypercortisolism. [Internet] [Thesis]. Universitat de Barcelona; 2015. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10803/384710.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Santos Vives A. Estudio neuropsicológico, neurorradiológico y clínico en el hipercortisolismo endógeno = Neuropsychological, neuroradiological and clinical study in endogenous hypercortisolism. [Thesis]. Universitat de Barcelona; 2015. Available from: http://hdl.handle.net/10803/384710

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

20. Genes-Hernandez, Luiza I. Development of a microfluidic based microvascular model : towards a complete blood brain barrier (BBB) mimic.

Degree: PhD, Department of Chemistry, 2008, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:39362

Subjects/Keywords: Multiple sclerosis – Research; Myelin sheath – Diseases – Research; Nitric oxide – Mechanism of action; Blood-brain barrier; Adenosine triphosphatase; Vascular endothelium; Microfluidics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Genes-Hernandez, L. I. (2008). Development of a microfluidic based microvascular model : towards a complete blood brain barrier (BBB) mimic. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:39362

Chicago Manual of Style (16^th Edition):

Genes-Hernandez, Luiza I. “Development of a microfluidic based microvascular model : towards a complete blood brain barrier (BBB) mimic.” 2008. Doctoral Dissertation, Michigan State University. Accessed March 07, 2021. http://etd.lib.msu.edu/islandora/object/etd:39362.

MLA Handbook (7^th Edition):

Genes-Hernandez, Luiza I. “Development of a microfluidic based microvascular model : towards a complete blood brain barrier (BBB) mimic.” 2008. Web. 07 Mar 2021.

Vancouver:

Genes-Hernandez LI. Development of a microfluidic based microvascular model : towards a complete blood brain barrier (BBB) mimic. [Internet] [Doctoral dissertation]. Michigan State University; 2008. [cited 2021 Mar 07]. Available from: http://etd.lib.msu.edu/islandora/object/etd:39362.

Council of Science Editors:

Genes-Hernandez LI. Development of a microfluidic based microvascular model : towards a complete blood brain barrier (BBB) mimic. [Doctoral Dissertation]. Michigan State University; 2008. Available from: http://etd.lib.msu.edu/islandora/object/etd:39362

21. 山本, 梓司. Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease. : 脱髄性疾患における環状ホスファチジン酸誘導体の脱髄抑制及び治療効果.

Degree: 博士(医学), 2018, Saitama Medical University / 埼玉医科大学

URL: http://id.nii.ac.jp/1386/00000615/

►

Multiple sclerosis is a neuroinflammatory demyelinating and neurodegenerative disease of the central nervous system characterized by recurrent and progressive demyelination/remyelination cycles, neuroinflammation, oligodendrocyte loss, demyelination,… (more)

▼

Multiple sclerosis is a neuroinflammatory demyelinating and neurodegenerative disease of the central nervous system characterized by recurrent and progressive demyelination/remyelination cycles, neuroinflammation, oligodendrocyte loss, demyelination, and axonal degeneration. Cyclic phosphatidic acid (cPA) is a natural phospholipid mediator with a unique cyclic phosphate ring structure at the sn-2 and sn-3 positions of the glycerol backbone. We reported earlier that cPA elicits a neurotrophin-like action and protects hippocampal neurons from ischemia-induced delayed neuronal death. We designed, chemically synthesized, and metabolically stabilized derivatives of cPA: 2-carba-cPA (2ccPA), a synthesized compound in which one of the phosphate oxygen molecules is replaced with a methylene group at the sn-2 position. In the present study, we investigated whether 2ccPA exerts protective effects in oligodendrocytes and suppresses pathology in the two most common mouse models of multiple sclerosis.

To evaluate whether 2ccPA has potential beneficial effects on the pathology of multiple sclerosis, we investigated the effects of 2ccPA on oligodendrocyte cell death in vitro and administrated 2ccPA to mouse models of experimental autoimmune encephalomyelitis (EAE) and cuprizone-induced demyelination.

We demonstrated that 2ccPA suppressed the CoCl

-induced increase in the Bax/Bcl-2 protein expression ratio and phosphorylation levels of p38MAPK and JNK protein. 2ccPA treatment reduced cuprizone-induced demyelination, microglial activation, NLRP3 inflammasome, and motor dysfunction. Furthermore, 2ccPA treatment reduced autoreactive T cells and macrophages, spinal cord injury, and pathological scores in EAE, the autoimmune multiple sclerosis mouse model.

We demonstrated that 2ccPA protected oligodendrocytes via suppression of the mitochondrial apoptosis pathway. Also, we found beneficial effects of 2ccPA in the multiperiod of cuprizone-induced demyelination and the pathology of EAE. These data indicate that 2ccPA may be a promising compound for the development of new drugs to treat demyelinating disease and ameliorate the symptoms of multiple sclerosis.

平成29年度

Subjects/Keywords: Animals; Anti-Inflammatory Agents; Apoptosis; Cell Differentiation; Cell Line, Transformed; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Gene Expression Regulation; Humans; MAP Kinase Signaling System; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Sheath; NLR Family, Pyrin Domain-Containing 3 Protein; Phosphatidic Acids; Proto-Oncogene Proteins c-bcl-2; p38 Mitogen-Activated Protein Kinases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

山本, �. (2018). Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease. : 脱髄性疾患における環状ホスファチジン酸誘導体の脱髄抑制及び治療効果. (Thesis). Saitama Medical University / 埼玉医科大学. Retrieved from http://id.nii.ac.jp/1386/00000615/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

山本, 梓司. “Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease. : 脱髄性疾患における環状ホスファチジン酸誘導体の脱髄抑制及び治療効果.” 2018. Thesis, Saitama Medical University / 埼玉医科大学. Accessed March 07, 2021. http://id.nii.ac.jp/1386/00000615/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

山本, 梓司. “Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease. : 脱髄性疾患における環状ホスファチジン酸誘導体の脱髄抑制及び治療効果.” 2018. Web. 07 Mar 2021.

Vancouver:

山本 �. Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease. : 脱髄性疾患における環状ホスファチジン酸誘導体の脱髄抑制及び治療効果. [Internet] [Thesis]. Saitama Medical University / 埼玉医科大学; 2018. [cited 2021 Mar 07]. Available from: http://id.nii.ac.jp/1386/00000615/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

山本 �. Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease. : 脱髄性疾患における環状ホスファチジン酸誘導体の脱髄抑制及び治療効果. [Thesis]. Saitama Medical University / 埼玉医科大学; 2018. Available from: http://id.nii.ac.jp/1386/00000615/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. Gatto, Cheryl Lynn. Novel Insights into Schwann Cell Dynamics in Peripheral Nervous System Myelination: a dissertation.

Degree: Cell Biology, Department of Cell Biology, Program in Neuroscience, 2004, U of Massachusetts : Med

URL: https://escholarship.umassmed.edu/gsbs_diss/213

► This body of work details the exploitation of an incredibly powerful neural culture system, which enables the in vitrostudy of events involved in peripheral… (more)

▼ This body of work details the exploitation of an incredibly powerful neural culture system, which enables the in vitrostudy of events involved in peripheral nervous system (PNS) development. Using a myelinating dorsal root ganglion (DRG) explant culture system, node of Ranvier formation and maintenance and the associated generation and maturation of myelin segments was examined. In addition, Schwann cell (SC) development, dynamics, and migration were extensively studied. First, in characterizing these cultures, the discrete axonal localization of specific ankyrin isoforms was revealed. Ankyrins are peripheral membrane proteins that immobilize classes of integral membrane proteins to the spectrin based-membrane skeleton. Ankyrins interact with proteins such as the voltage-dependent/gated sodium channel (vgsc) and members of the L1 family of cell adhesion molecules. These interactions are physiologically relevant to the formation of membrane specializations involved in axon guidance and the initiation and propagation of action potentials. We examined ankyrin_B and ankyrin_G expression in cultured DRG explants, which allowed visualization of individual axons. Ankyrin_B and ankyrin_G exhibited differential localizations to specific axonal populations. This was evident as early as one day in vitro and persisted over time. In mature pre-myelinated cultures, axons having an apparent diameter of less than 1 µm predominantly expressed ankyrin_B, whereas axons having a diameter greater than or equal to 1 µm predominantly expressed ankyrin_G (based on immunocytochemical reactivity). When myelination was induced, ankyrin_Gwas appropriately localized to sites of nodal development flanked by myelinating glial processes in the large caliber axons. These observations suggest that axons destined for myelination may express a distinct complement of peripheral, and perhaps integral, membrane proteins as compared to those observed in non-myelinated axons. These distinguishing features may play a role in the selection of axons for myelination. This work was followed with defining the role axo-glial interactions play in organizing domains along the axon being myelinated. Nodes of Ranvier are specialized, highly polarized axonal domains crucial to the propagation of saltatory action potentials. In the PNS, axon-glial cell contacts have been implicated in SC differentiation and the formation of nodes of Ranvier. SC microvilli establish axonal contact at mature nodes, and their components have been observed to localize early to sites of developing nodes. However, a role for these contacts in node formation remains controversial. Using the myelinating explant culture system, we observed that SCs reorganize and polarize microvillar components, such as the ezrin-binding phosphoprotein 50kDa (EBP50)/regulatory co-factor of the sodium-hydrogen exchanger isoform 3 (NHERF-1), actin, and the activated ezrin, radixin, and moesin… Advisors/Committee Members: Stephen Lambert, Ph.D..

Subjects/Keywords: Peripheral Nervous System; Ankyrins; Ganglia; Spinal; Myelin Sheath; Ranvier's Nodes; Schwann Cells; Amino Acids, Peptides, and Proteins; Cells; Nervous System; Neuroscience and Neurobiology; Tissues

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gatto, C. L. (2004). Novel Insights into Schwann Cell Dynamics in Peripheral Nervous System Myelination: a dissertation. (Doctoral Dissertation). U of Massachusetts : Med. Retrieved from https://escholarship.umassmed.edu/gsbs_diss/213

Chicago Manual of Style (16^th Edition):

Gatto, Cheryl Lynn. “Novel Insights into Schwann Cell Dynamics in Peripheral Nervous System Myelination: a dissertation.” 2004. Doctoral Dissertation, U of Massachusetts : Med. Accessed March 07, 2021. https://escholarship.umassmed.edu/gsbs_diss/213.

MLA Handbook (7^th Edition):

Gatto, Cheryl Lynn. “Novel Insights into Schwann Cell Dynamics in Peripheral Nervous System Myelination: a dissertation.” 2004. Web. 07 Mar 2021.

Vancouver:

Gatto CL. Novel Insights into Schwann Cell Dynamics in Peripheral Nervous System Myelination: a dissertation. [Internet] [Doctoral dissertation]. U of Massachusetts : Med; 2004. [cited 2021 Mar 07]. Available from: https://escholarship.umassmed.edu/gsbs_diss/213.

Council of Science Editors:

Gatto CL. Novel Insights into Schwann Cell Dynamics in Peripheral Nervous System Myelination: a dissertation. [Doctoral Dissertation]. U of Massachusetts : Med; 2004. Available from: https://escholarship.umassmed.edu/gsbs_diss/213

Universitat de Barcelona

23. Gil Fernández, Vanessa. Funciones de las proteínas asociadas a mielina durante el desarrollo del sistema nervioso central y en neurodegeneración.

Degree: Departament de Biologia Cel·lular, 2010, Universitat de Barcelona

URL: http://hdl.handle.net/10803/666668

► El potencial regenerativo del sistema nervioso central (SNC), a diferencia del sistema nervioso periférico (SNP), desaparece gradualmente conforme avanza el desarrollo, coincidiendo con el inicio… (more)

▼ El potencial regenerativo del sistema nervioso central (SNC), a diferencia del sistema nervioso periférico (SNP), desaparece gradualmente conforme avanza el desarrollo, coincidiendo con el inicio de la mielinización. Hasta el momento, se ha descrito la existencia de tres proteínas asociadas a la mielina (MAIPs) que estarían implicadas en este proceso. Estas proteínas, Nogo-A, MAG y OMgp, se unen, de forma independiente, a un complejo receptor neuronal común formado por NgR1, p75 o TAJ-1/TROY y Lingo-1, y la activación de este complejo receptor desencadena una señalización intracelular que causa la pérdida de plasticidad en el SNC adulto y la inhibición de la regeneración axonal tras lesión. Sin embargo, los estudios publicados en el momento de iniciarse el presente trabajo sugerían que, tanto los ligandos como los componentes del complejo receptor, podrían ejercer otras funciones no relacionadas con la inhibición de la regeneración axonal en el adulto. Además, aunque se acababa de describir que Lingo-1 era miembro esencial del complejo receptor para las MAIPs, no se había demostrado si los tres componentes propuestos para formar el complejo receptor compartían el mismo patrón de expresión, ni tampoco si podían coexistir en el mismo tipo celular y compartimento. Por ello, nos propusimos analizar en detalle el patrón de expresión de Lingo-1 y de su distribución celular en relación al resto de componentes del complejo. Nuestros resultados muestran la coexistencia de Lingo-1, NgR1, p75 y TROY en el cerebro de ratón durante una ventana temporal postnatal muy definida. También hemos determinado la distribución de Lingo-1 en determinadas subpoblaciones neuronales. Sorprendentemente, Lingo-1 se expresa en estadios tempranos del desarrollo en los cuales no se expresa NgR1. Finalmente, mostramos que el dominio intracelular de Lingo-1 contribuye a la señalización y además interacciona con la proteína postmitótica neuronal Myt1l, sugiriendo que Lingo-1 puede regular la actividad de este factor de transcripción al afectar a su localización subcelular. Por otra parte, existían ciertas discrepancias en cuanto al tipo celular en el que se expresaba OMgp. Mientras algunos estudios sostenían una localización exclusiva en oligodendrocitos, otros proponían una expresión neuronal. Además, todos los estudios de expresión descritos hasta la fecha se centraban en estadios postnatales y adultos, pero no en estadios embrionarios. Así, uno de nuestros objetivos fue profundizar en la distribución celular y regional de las proteínas OMgp a lo largo del desarrollo del telencéfalo de ratón y determinar posibles funciones adicionales. Observamos que, a nivel celular, OMgp se localiza en membranas neuronales de dendritas y axones y también en fracciones sinaptosomales de cerebro y en estructuras similares a botones sinápticos. Además, la aparición de la inmunoreactividad en la corteza durante el desarrollo coincide con el establecimiento de la conexión tálamo-cortical y, por tanto, de la formación de los barriles (barrel-field) de la… Advisors/Committee Members: [email protected] (authoremail), false (authoremailshow), Río Fernández, José Antonio del (director), Río Fernández, José Antonio del (tutor).

Subjects/Keywords: Sistema nerviós central; Sistema nervioso central; Central nervous system; Regeneració del sistema nerviós; Regeneración del sistema nervioso; Nervous system regeneration; Expressió gènica; Expresión génica; Gene expression; Proteïnes de membrana; Proteínas de membranas; Membrane proteins; Mielina; Myelin sheath; Hipocamp (Cervell); Hipocampo (Cerebro); Hippocampus (Brain); Ciències Experimentals i Matemàtiques; 576

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gil Fernández, V. (2010). Funciones de las proteínas asociadas a mielina durante el desarrollo del sistema nervioso central y en neurodegeneración. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/666668

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gil Fernández, Vanessa. “Funciones de las proteínas asociadas a mielina durante el desarrollo del sistema nervioso central y en neurodegeneración.” 2010. Thesis, Universitat de Barcelona. Accessed March 07, 2021. http://hdl.handle.net/10803/666668.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gil Fernández, Vanessa. “Funciones de las proteínas asociadas a mielina durante el desarrollo del sistema nervioso central y en neurodegeneración.” 2010. Web. 07 Mar 2021.

Vancouver:

Gil Fernández V. Funciones de las proteínas asociadas a mielina durante el desarrollo del sistema nervioso central y en neurodegeneración. [Internet] [Thesis]. Universitat de Barcelona; 2010. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10803/666668.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gil Fernández V. Funciones de las proteínas asociadas a mielina durante el desarrollo del sistema nervioso central y en neurodegeneración. [Thesis]. Universitat de Barcelona; 2010. Available from: http://hdl.handle.net/10803/666668

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

24. Nocentini, Sara. Potential of genetically modified ensheathing cells for regeneration after spinal cord injury = Potencial de la glía envolvente genéticamente modificada para la regeneración después de lesión medular.

Degree: Departament de Biologia Cel·lular, 2014, Universitat de Barcelona

URL: http://hdl.handle.net/10803/145379

► La implantación de OECs ha surgido como una terapia prometedora para lesiones medulares, pero sus propiedades regenerativas parecen depender de la presencia de un sustrato… (more)

▼ La implantación de OECs ha surgido como una terapia prometedora para lesiones medulares, pero sus propiedades regenerativas parecen depender de la presencia de un sustrato permisivo para la migración celular. En esta Tesis Doctoral demostramos que los inhibidores asociados a mielina (IAMs) pueden modular la capacitad migración de las OECs través la interacción y activación del complejo receptor de NgR (el receptor común para los IAMs). Con el uso de la microscopia de tracción, demostramos cuantitativamente que las OECs disminuyen en gran medida su fuerza de tracción sobre la mielina. Además, esta disminución se pudo correlacionar con una disminución de las adhesiones focales y la redistribución del citoesqueleto de F-actina. La incubación con el péptido NEP1-40, que bloquea NgR1, restableció in gran parte la capacitad migratoria, las fuerzas de tracción de estas células y su organización citoesqueletal. En base a los resultados obtenidos exploramos la viabilidad de dos estrategias diferentes para mejorar las propiedades migratorias de la OECs. Una de ellas trataba del posible uso de nanoparticulas magnéticas para guiar a las células. Aunque esta técnica no aumenta la velocidad intrínseca de migración de las células, permite la concentración y la guía de las mismas hace a un área específica después de la implantación in vivo. Pudimos comprobar que las OECs marcada con NPM no exhiben respuestas celulares asociadas al estrés, y pueden ser guiadas por un campo magnético in vitro. Además comprobamos que las células se integraban bien después de su trasplante de en un modelo organotípico de regeneración de médula espinal/nervio ciático. La segunda estrategia consistió en modificar genéticamente las OECs para que expresaran un ectodomínio por el NgR1 para bloquear los efectos negativos de los IAMs sobre su migración. Pudimos observar que las células modificadas migran más in vitro sobre un sustrato de mielinas comparadas con OECs normales. Además, una vez implantadas en una médula no lesionada, las células modificadas se integran bien en el modelo y migran más que células normal. Los resultados obtenidos indican un potencial terapéutico de ambas estrategias. Advisors/Committee Members: [email protected] (authoremail), false (authoremailshow), Del Rio, José Antonio (director), Bribian Arruego, Ana (codirector), true (authorsendemail).

Subjects/Keywords: Lesions medul·lars; Lesiones medulares; Spinal cord injuries; Mielina; Myelin sheath; Inhibidors enzimàtics; Inhibidores enzimáticos; Enzyme inhibitors; Neuròglia; Neuroglia; Ciències Experimentals i Matemàtiques; 576

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APA (6^th Edition):

Nocentini, S. (2014). Potential of genetically modified ensheathing cells for regeneration after spinal cord injury = Potencial de la glía envolvente genéticamente modificada para la regeneración después de lesión medular. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/145379

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nocentini, Sara. “Potential of genetically modified ensheathing cells for regeneration after spinal cord injury = Potencial de la glía envolvente genéticamente modificada para la regeneración después de lesión medular.” 2014. Thesis, Universitat de Barcelona. Accessed March 07, 2021. http://hdl.handle.net/10803/145379.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nocentini, Sara. “Potential of genetically modified ensheathing cells for regeneration after spinal cord injury = Potencial de la glía envolvente genéticamente modificada para la regeneración después de lesión medular.” 2014. Web. 07 Mar 2021.

Vancouver:

Nocentini S. Potential of genetically modified ensheathing cells for regeneration after spinal cord injury = Potencial de la glía envolvente genéticamente modificada para la regeneración después de lesión medular. [Internet] [Thesis]. Universitat de Barcelona; 2014. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10803/145379.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nocentini S. Potential of genetically modified ensheathing cells for regeneration after spinal cord injury = Potencial de la glía envolvente genéticamente modificada para la regeneración después de lesión medular. [Thesis]. Universitat de Barcelona; 2014. Available from: http://hdl.handle.net/10803/145379

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Florida

25. Yeomans, David Clifford, 1957-. Differential effects of systemic morphine on nociception elicited by activation of myelinated and unmyelinated afferent fibers in human and nonhuman primates.

Degree: 1989, University of Florida

URL: https://ufdc.ufl.edu/AA00054349

Subjects/Keywords: Dosage; Mental stimulation; Monkeys; Morphine; Nociceptors; Pain; Paradigms; Physiological stimulation; Reflexes; Skin temperature; Department of Neuroscience thesis Ph.D ( mesh ); Morphine ( mesh ); Myelin Sheath – physiology ( mesh ); Neurons, Afferent ( mesh ); Nociceptors – physiology ( mesh ); Primates ( mesh ); Research ( mesh )

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APA (6^th Edition):

Yeomans, David Clifford, 1. (1989). Differential effects of systemic morphine on nociception elicited by activation of myelinated and unmyelinated afferent fibers in human and nonhuman primates. (Thesis). University of Florida. Retrieved from https://ufdc.ufl.edu/AA00054349

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yeomans, David Clifford, 1957-. “Differential effects of systemic morphine on nociception elicited by activation of myelinated and unmyelinated afferent fibers in human and nonhuman primates.” 1989. Thesis, University of Florida. Accessed March 07, 2021. https://ufdc.ufl.edu/AA00054349.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yeomans, David Clifford, 1957-. “Differential effects of systemic morphine on nociception elicited by activation of myelinated and unmyelinated afferent fibers in human and nonhuman primates.” 1989. Web. 07 Mar 2021.

Vancouver:

Yeomans, David Clifford 1. Differential effects of systemic morphine on nociception elicited by activation of myelinated and unmyelinated afferent fibers in human and nonhuman primates. [Internet] [Thesis]. University of Florida; 1989. [cited 2021 Mar 07]. Available from: https://ufdc.ufl.edu/AA00054349.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yeomans, David Clifford 1. Differential effects of systemic morphine on nociception elicited by activation of myelinated and unmyelinated afferent fibers in human and nonhuman primates. [Thesis]. University of Florida; 1989. Available from: https://ufdc.ufl.edu/AA00054349

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

26. Rickards, Tyler. White Matter Integrity In Adults With Hemiparetic Multiple Sclerosis Given Constraint-Induced Movement Therapy.

Degree: 2014, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,1619

►

In adults with chronic stroke and children with cerebral palsy, structural changes in grey matter correlate with clinical improvements due to an efficacious upper-extremity (UE)… (more)

▼

In adults with chronic stroke and children with cerebral palsy, structural changes in grey matter correlate with clinical improvements due to an efficacious upper-extremity (UE) rehabilitation therapy, Constraint-Induced Movement (CI) Therapy. Changes in white matter following CI therapy have not been observed, but damage to white matter tracts has not been found to decrease motor improvement resulting from this treatment. The objectives of this project were to: 1) evaluate the efficacy of CI therapy compared to complementary and alternative medicine (CAM) treatments on improving impaired UE function in participants with the progressive form of multiple sclerosis (MS), 2) investigate whether white matter integrity is correlated with motor function prior to treatment and improvement due to therapy, and 3) determine if change in white matter tracts is associated with CI therapy. Diffusion Tensor Imaging (DTI) was utilized to quantify white matter integrity.Eighteen participants with hemiparetic slowly progressing MS received either CI therapy or a set of CAM techniques. Fractional anisotropy (FA) values were calculated over the whole brain prior to and following treatment and tractography was used to isolate the corticospinal tract (CST).The CI therapy group improved use of the more-affected arm in the life situation that was 4.1 times greater than the CAM group. The groups improved similarly on the in-laboratory measure of arm function. FA value of the CST was not related to motor function. Pretreatment contralateral CST FA value correlated with motor improvement following CI therapy, but not CAM treatments. These results confirm the efficacy of CI therapy in improving motor function in individuals with CNS damage. The lack of a relationship between pretreatment motor function and integrity of the CST in individuals with MS may suggest that motor function relates to another structure necessary for motor function and a site of frequent pathology in individuals with MS: the spinal cord. Pretreatment integrity of the CST related to improvement in motor function following CI therapy.

PhD

1 online resource (ix, 41 pages) :illustrations (some color), facsimiles

Psychology

brain, CI therpay, MRI, Multiple Sclerosis, rehabilitation, white matter

UNRESTRICTED

Advisors/Committee Members: Edward Taub, Knight,David Mark, Victor W. Rinker,John Uswatte,Gitendra.

Subjects/Keywords: Constraint-induced movement therapy – Physiological effect.<; br>; Multiple sclerosis – Treatment.<; br>; Multiple sclerosis – Alternative treatment.<; br>; Pyramidal tract – Magnetic resonance imaging.<; br>; Myelin sheath – Magnetic resonance imaging.

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APA (6^th Edition):

Rickards, T. (2014). White Matter Integrity In Adults With Hemiparetic Multiple Sclerosis Given Constraint-Induced Movement Therapy. (Thesis). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1619

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rickards, Tyler. “White Matter Integrity In Adults With Hemiparetic Multiple Sclerosis Given Constraint-Induced Movement Therapy.” 2014. Thesis, University of Alabama – Birmingham. Accessed March 07, 2021. http://contentdm.mhsl.uab.edu/u?/etd,1619.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rickards, Tyler. “White Matter Integrity In Adults With Hemiparetic Multiple Sclerosis Given Constraint-Induced Movement Therapy.” 2014. Web. 07 Mar 2021.

Vancouver:

Rickards T. White Matter Integrity In Adults With Hemiparetic Multiple Sclerosis Given Constraint-Induced Movement Therapy. [Internet] [Thesis]. University of Alabama – Birmingham; 2014. [cited 2021 Mar 07]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1619.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rickards T. White Matter Integrity In Adults With Hemiparetic Multiple Sclerosis Given Constraint-Induced Movement Therapy. [Thesis]. University of Alabama – Birmingham; 2014. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1619

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

27. Liu, Jiliang. Scanning x-ray microdiffraction studies of the molecular architecture of biological tissues.

Degree: PhD, Department of Electrical and Computer Engineering, 2016, Northeastern University

URL: http://hdl.handle.net/2047/D20195172

► X-ray scattering is an important method to study atomic and molecular structures. Here, I apply scanning x-ray micro-diffraction, a new advanced synchrotron technology, to study… (more)

Subjects/Keywords: amyloid fibril; feature extraction; molecular stucture; scanning microdiffraction; X-rays; Diffraction; X-rays; Scattering; Arabidopsis; Molecular aspects; Cellulose; Structure; Myelin sheath; Structure; Amyloid beta-protein; Structure; Alzheimer's disease; Molecular aspects

…myelin. Dr. Kirschner’s lab prepares the nerve fiber for SXMD study on myelin sheath. My first… …Data processing, Myelin sheath, Arabidopsis, Cellulose, Amyloid, Fibril, Molecular structure… …structural variations of myelin sheath at specialized regions known as the internode, juxtaparanode… …Figure 1 shows GM/CA at APS. 1.2 Myelin Sheath Transmission of electrical signals along a… …nerve axon is greatly accelerated by the presence of an insulating myelin sheath that is…

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APA (6^th Edition):

Liu, J. (2016). Scanning x-ray microdiffraction studies of the molecular architecture of biological tissues. (Doctoral Dissertation). Northeastern University. Retrieved from http://hdl.handle.net/2047/D20195172

Chicago Manual of Style (16^th Edition):

Liu, Jiliang. “Scanning x-ray microdiffraction studies of the molecular architecture of biological tissues.” 2016. Doctoral Dissertation, Northeastern University. Accessed March 07, 2021. http://hdl.handle.net/2047/D20195172.

MLA Handbook (7^th Edition):

Liu, Jiliang. “Scanning x-ray microdiffraction studies of the molecular architecture of biological tissues.” 2016. Web. 07 Mar 2021.

Vancouver:

Liu J. Scanning x-ray microdiffraction studies of the molecular architecture of biological tissues. [Internet] [Doctoral dissertation]. Northeastern University; 2016. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/2047/D20195172.

Council of Science Editors:

Liu J. Scanning x-ray microdiffraction studies of the molecular architecture of biological tissues. [Doctoral Dissertation]. Northeastern University; 2016. Available from: http://hdl.handle.net/2047/D20195172

28. Seira Oriach, Oscar. Estudio de las vías de señalización intracelular asociadas a las proteínas inhibitorias de la mielina.

Degree: Departament de Biologia Cel·lular, 2012, Universitat de Barcelona

URL: http://hdl.handle.net/10803/83901

► Lesioned axons do not regenerate in the adult mammalian central nervous system, owing to the overexpression of inhibitory molecules such as myelin-derived proteins or chondroitin… (more)

Subjects/Keywords: Inhibición axonal; Inhibició axonal; Organotípico; Organotípic; Regeneració del sistema nerviós; Regeneración del sistema nervioso; Nervous system regeneration; Mielina; Myelin sheath; Sinapsi; Sinapsis; Synapses; Plasticitat sinàptica; Plasticidad sináptica; Ciències Experimentals i Matemàtiques; 576

…rich repeat neuronal 6a LTD Long Term Depression LTP Long Term Potentiation MAG Myelin… …Associated Protein MBP Myelin Basic Protein MEA Micro-Electron Array MHC1 Major… …Mammalian Target of Rapamycin Myt1l Myelin transcription factor 1-like NEP1-40 Nogo… …Oligodendrocyte Myelin glycoprotein iv oml outer molecular layer PDMS Polidimetilsiloxane PDPK… …2000), myelin-associated glycoprotein (MAG) (McKerracher et al., 1994…

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APA (6^th Edition):

Seira Oriach, O. (2012). Estudio de las vías de señalización intracelular asociadas a las proteínas inhibitorias de la mielina. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/83901

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Seira Oriach, Oscar. “Estudio de las vías de señalización intracelular asociadas a las proteínas inhibitorias de la mielina.” 2012. Thesis, Universitat de Barcelona. Accessed March 07, 2021. http://hdl.handle.net/10803/83901.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Seira Oriach, Oscar. “Estudio de las vías de señalización intracelular asociadas a las proteínas inhibitorias de la mielina.” 2012. Web. 07 Mar 2021.

Vancouver:

Seira Oriach O. Estudio de las vías de señalización intracelular asociadas a las proteínas inhibitorias de la mielina. [Internet] [Thesis]. Universitat de Barcelona; 2012. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10803/83901.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Seira Oriach O. Estudio de las vías de señalización intracelular asociadas a las proteínas inhibitorias de la mielina. [Thesis]. Universitat de Barcelona; 2012. Available from: http://hdl.handle.net/10803/83901

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Jenkins, Andrew. Conformational Transitions of 18.5-kilodaltons Myelin Basic Protein Studied by Fluorescence Spectroscopy and Forster Resonance Energy Transfer.

Degree: MS, Department of Molecular and Cellular Biology, 2015, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8793

► The intrinsically-disordered, 18.5-kiloDalton (kDa) isoform of myelin basic protein (MBP) is a peripheral membrane protein that is essential to proper myelin formation in the central… (more)

Subjects/Keywords: ANS; FRET; Myelin Basic Protein; a-helical; a-helix; alpha-helical; Anilinonaphthalene; Bamm; binding-induced folding; Central Nervous System; Circular Dichroism; CNS; Conformational transitions; deconvolution; deconvolve; deimination; demyelinate; demyelination; disorder to a helical; disorder to order; disordered conformation; Fluoescence; Fluorescence Anisotropy; Fluorescence Spectroscopy; Forster Resonance Energy Transfer; Harauz; IAEDANS; IDP; Intrinsically disordered; Intrinsically disordered protein; Jenkins; kilodaltons; long range intramolecular folding; MBP; MBP-UTC1; MBP-UTC8; membrane mimetic solvents; MS; Multiple Sclerosis; mutagenesis; myelin sheath; neurodegeneration; oligodendrocyte; PAD2; peptidylarginine deiminase type 2; post-translational modification; PTM; random coil; recombinant; recombinant MBP; remyelinate; TFE; thermodynamic ensembles; titration curves; trifluoroethanal; Vassall

…myelin sheath is a distinctive membrane complex formed when multiple spiralwrapped lamellae… …membrane extends towards and makes physical contact with the axon and initiates myelin sheath… …formation, concentrically winding itself onto an axon (1, 2). The myelin sheath is… …x28;8). Any disruption of the myelin sheath integrity compromises the ability of nerves… …Figure #1 shows the structure of myelin sheath itself, composed of repeating lipid bilayers…

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APA (6^th Edition):

Jenkins, A. (2015). Conformational Transitions of 18.5-kilodaltons Myelin Basic Protein Studied by Fluorescence Spectroscopy and Forster Resonance Energy Transfer. (Masters Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8793

Chicago Manual of Style (16^th Edition):

Jenkins, Andrew. “Conformational Transitions of 18.5-kilodaltons Myelin Basic Protein Studied by Fluorescence Spectroscopy and Forster Resonance Energy Transfer.” 2015. Masters Thesis, University of Guelph. Accessed March 07, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8793.

MLA Handbook (7^th Edition):

Jenkins, Andrew. “Conformational Transitions of 18.5-kilodaltons Myelin Basic Protein Studied by Fluorescence Spectroscopy and Forster Resonance Energy Transfer.” 2015. Web. 07 Mar 2021.

Vancouver:

Jenkins A. Conformational Transitions of 18.5-kilodaltons Myelin Basic Protein Studied by Fluorescence Spectroscopy and Forster Resonance Energy Transfer. [Internet] [Masters thesis]. University of Guelph; 2015. [cited 2021 Mar 07]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8793.

Council of Science Editors:

Jenkins A. Conformational Transitions of 18.5-kilodaltons Myelin Basic Protein Studied by Fluorescence Spectroscopy and Forster Resonance Energy Transfer. [Masters Thesis]. University of Guelph; 2015. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8793

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