subject:(Mycophenolic acid)

University of Cincinnati

1. WEIMERT, NICOLE A. A 12-month, prospective, randomized, single center, open label pilot study to evaluate the safety and efficacy of Myfortic in combination with tacrolimus and Thymoglobulin in early corticosteroid withdrawal.

Degree: MS, Medicine : Epidemiology (Environmental Health), 2008, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1211828943

► In 2005, greater than 16,000 kidney transplants were performed in the United States, with 68% of grafts functioning at 5 years (United Organ Sharing Network).… (more)

Subjects/Keywords: Health Care; mycophenolic acid; pharmacokinetic; kidney; transplant

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APA (6^th Edition):

WEIMERT, N. A. (2008). A 12-month, prospective, randomized, single center, open label pilot study to evaluate the safety and efficacy of Myfortic in combination with tacrolimus and Thymoglobulin in early corticosteroid withdrawal. (Masters Thesis). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1211828943

Chicago Manual of Style (16^th Edition):

WEIMERT, NICOLE A. “A 12-month, prospective, randomized, single center, open label pilot study to evaluate the safety and efficacy of Myfortic in combination with tacrolimus and Thymoglobulin in early corticosteroid withdrawal.” 2008. Masters Thesis, University of Cincinnati. Accessed December 07, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1211828943.

MLA Handbook (7^th Edition):

WEIMERT, NICOLE A. “A 12-month, prospective, randomized, single center, open label pilot study to evaluate the safety and efficacy of Myfortic in combination with tacrolimus and Thymoglobulin in early corticosteroid withdrawal.” 2008. Web. 07 Dec 2019.

Vancouver:

WEIMERT NA. A 12-month, prospective, randomized, single center, open label pilot study to evaluate the safety and efficacy of Myfortic in combination with tacrolimus and Thymoglobulin in early corticosteroid withdrawal. [Internet] [Masters thesis]. University of Cincinnati; 2008. [cited 2019 Dec 07]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1211828943.

Council of Science Editors:

WEIMERT NA. A 12-month, prospective, randomized, single center, open label pilot study to evaluate the safety and efficacy of Myfortic in combination with tacrolimus and Thymoglobulin in early corticosteroid withdrawal. [Masters Thesis]. University of Cincinnati; 2008. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1211828943

Universiteit Utrecht

2. Fakunle, V.T.A. Mycophenolic Acid as a Contminant in Food and Feed.

Degree: 2012, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/252105

► Mycophenolic acid (MPA) is a toxic metabolite produced by many Penicillium species among which are P. brevicompactum and P. roqueforti. Byssochlamys nivea, a yeast species,… (more)

▼ Mycophenolic acid (MPA) is a toxic metabolite produced by many Penicillium species among which are P. brevicompactum and P. roqueforti. Byssochlamys nivea, a yeast species, has also been reported to produce MPA. MPA producing fungi are frequently isolated from maize and grass silage (animal feed) for example P.roqueforti. Byssochlamys species are also responsible for spoilage and degradation of fruits and silages. P. brevicompactum has been isolated from a wide range of human foods. P. roqueforti is used in the production of blue-veined cheeses, thus MPA has been detected in most of this type of cheese. Animals are exposed to MPA through the ingestion of contaminated feeds. MPA or majority of MPA producing fungi have been found in animal feed thus could be carried over to human foods of animal origin. MPA has not been detected in milk so far, but up to 0.23mg/kg has been found in sheep muscle tissue. The possibility for MPA occurrence in fruit is high but this has not been extensively studied yet. The major route of for human exposure is therefore dietary. From the available data, exposure of humans and animals to MPA seems to be considerably high (>0.1mg/day for humans, 900mg/day for cattle and1.8mg/kg body weight for livestock in general). This could have health consequences especially considering that humans and animals are chronically exposed to this compound. The calculated Acceptable Daily Intake (ADI) for humans is 0.195mg and that for cattle is 1.8mg. Due to the genotoxic nature of MPA (although results of genotoxicity assays are conflicting), the Margin of Exposure (MOE) of MPA for humans has been calculated which is 1000; thus it is a substance with a high risk for which urgent risk management measures are required. The few clinical studies on animal subjects have also been strictly limited to the acute, rather than chronic, toxin exposure. Chronic exposure studies however will be more relevant to real life situation. Human exposure to MPA has not been extensively studied, thus there are only a few data on its concentration in human food products. The consumption of blue-veined cheese is a major route of human exposure. However, the cumulative exposure from different food sources which should be of health concern has not been studied. MPA has a number of therapeutic uses, the most important of which is, its use as an immunosuppressant drug in renal transplant, lupus nephritis, non-infectious ocular inflammation and in the management of difficult inflammatory bowel diseases. Advisors/Committee Members: Fink-Gremmels-Gehrmann, Prof. J..

Subjects/Keywords: Mycophenolic acid (MPA); mycotoxin; immunosuppression; mycophenolate (MMF)

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APA (6^th Edition):

Fakunle, V. T. A. (2012). Mycophenolic Acid as a Contminant in Food and Feed. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/252105

Chicago Manual of Style (16^th Edition):

Fakunle, V T A. “Mycophenolic Acid as a Contminant in Food and Feed.” 2012. Masters Thesis, Universiteit Utrecht. Accessed December 07, 2019. http://dspace.library.uu.nl:8080/handle/1874/252105.

MLA Handbook (7^th Edition):

Fakunle, V T A. “Mycophenolic Acid as a Contminant in Food and Feed.” 2012. Web. 07 Dec 2019.

Vancouver:

Fakunle VTA. Mycophenolic Acid as a Contminant in Food and Feed. [Internet] [Masters thesis]. Universiteit Utrecht; 2012. [cited 2019 Dec 07]. Available from: http://dspace.library.uu.nl:8080/handle/1874/252105.

Council of Science Editors:

Fakunle VTA. Mycophenolic Acid as a Contminant in Food and Feed. [Masters Thesis]. Universiteit Utrecht; 2012. Available from: http://dspace.library.uu.nl:8080/handle/1874/252105

University of Hong Kong

3. Mok, Ka-yi. Antiviral activity of mycophenolic acid against influenza viruses and MERS coronavirus.

Degree: M. Phil., 2014, University of Hong Kong

URL: Mok, K. [莫嘉怡]. (2014). Antiviral activity of mycophenolic acid against influenza viruses and MERS coronavirus. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5388009 ; http://dx.doi.org/10.5353/th_b5388009 ; http://hdl.handle.net/10722/222428

► Influenza virusand Middle East Respiratory Syndrome Coronavirus(MERS-CoV) cause life-threatening respiratory disease. There are 3 to 5million severe cases and 250,000 to 500,000 fatal cases caused… (more)

▼ Influenza virusand Middle East Respiratory Syndrome Coronavirus(MERS-CoV) cause life-threatening respiratory disease. There are 3 to 5million severe cases and 250,000 to 500,000 fatal cases caused by seasonal influenza virus A(H1N1)virus, A(H3N2) virus and influenza B virus every year. Pandemic influenza, which is associated with higher mortality, has once every few decades. Among various influenza viruses, the avian-origin A(H5N1)virus and A(H7N9) virus are the most virulent in humans. MERS-CoV was first reported to cause severe human infections in2012, and now there are over 800 cases worldwide with a case-fatality rate of about 30%. Antiviral is one of the armamentaria in the treatment of influenza virus and MERS-CoV infection. For influenza viruses, the neuraminidase inhibitors oseltamivir and zanamivir have been used in the treatment of influenza A and B infection. However, the clinical efficacy has been questioned, and delayed administration of NAIs has been associated with poor outcome. Favipiravir, a viral RNA polymerase inhibitor, has been approved only in Japan. Novelantivirals are still under development and unlikely to be available in the near future. No antivirals against MERS-CoV have been approved for clinical use yet. Since effective antivirals against influenza virus and MERS-CoV are urgently needed, we investigated whether an approved drug, mycophenolic acid (MPA),can have antiviral activity. In this thesis, we investigated the antiviral effect of MPA against the A(H1N1)pdm09 virus, influenza B virus, A(H7N9) virus, and MERS-CoV. MPA, which is available for clinical use as mycophenolate mofetil (MMF)or mycophenolate sodium, has been used as immunosuppressant for transplant recipients and in the treatment of autoimmune diseases.MPA suppresses the synthesis of guanosine in the de novo pathway. MPA has been reported to have antimicrobial activities against several viruses and fungi. Time-of-addition experiment showed that earlier addition of MPA led to better cell protectionon influenza infection. The EC50of MPA added 2 hours before virus inoculation was 1.510 µM. The EC50of MPA was >12.5 µM when MPA was added 7 hours after virus inoculation. Cell protection assay showed that MPA protected cells infected with influenza viruses(EC50, 0.208-1.510µM)or MERS-CoV(EC50, 0.531 µM). Virus yield reduction assay showed that the growth of influenza viruses and MERS-CoV were reduced in dose-dependent manner in the presence of MPA. Plaque reduction assay also showed that MPA inhibited the growth of influenza virus(EC50, 0.528-0.872 µM) and MERS-CoV (EC50, 0.395µM). Among influenza viruses, the activity of MPA against influenza B virus was most potent. Assay assessing nucleoprotein expression revealed that nucleoprotein expression in influenza A virus was completely inhibited in the presence of 12.5 µM of MPA. Addition of guanosine, but not adenosine, revertedthe antiviral activity of MPA on influenza infection completely, suggesting that the antiviral activity is dependent on the depletion of guanosine. In…

Subjects/Keywords: Mycophenolic acid; Coronavirus infections - Treatment; Influenza - Treatment

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APA (6^th Edition):

Mok, K. (2014). Antiviral activity of mycophenolic acid against influenza viruses and MERS coronavirus. (Masters Thesis). University of Hong Kong. Retrieved from Mok, K. [莫嘉怡]. (2014). Antiviral activity of mycophenolic acid against influenza viruses and MERS coronavirus. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5388009 ; http://dx.doi.org/10.5353/th_b5388009 ; http://hdl.handle.net/10722/222428

Chicago Manual of Style (16^th Edition):

Mok, Ka-yi. “Antiviral activity of mycophenolic acid against influenza viruses and MERS coronavirus.” 2014. Masters Thesis, University of Hong Kong. Accessed December 07, 2019. Mok, K. [莫嘉怡]. (2014). Antiviral activity of mycophenolic acid against influenza viruses and MERS coronavirus. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5388009 ; http://dx.doi.org/10.5353/th_b5388009 ; http://hdl.handle.net/10722/222428.

MLA Handbook (7^th Edition):

Mok, Ka-yi. “Antiviral activity of mycophenolic acid against influenza viruses and MERS coronavirus.” 2014. Web. 07 Dec 2019.

Vancouver:

Mok K. Antiviral activity of mycophenolic acid against influenza viruses and MERS coronavirus. [Internet] [Masters thesis]. University of Hong Kong; 2014. [cited 2019 Dec 07]. Available from: Mok, K. [莫嘉怡]. (2014). Antiviral activity of mycophenolic acid against influenza viruses and MERS coronavirus. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5388009 ; http://dx.doi.org/10.5353/th_b5388009 ; http://hdl.handle.net/10722/222428.

Council of Science Editors:

Mok K. Antiviral activity of mycophenolic acid against influenza viruses and MERS coronavirus. [Masters Thesis]. University of Hong Kong; 2014. Available from: Mok, K. [莫嘉怡]. (2014). Antiviral activity of mycophenolic acid against influenza viruses and MERS coronavirus. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5388009 ; http://dx.doi.org/10.5353/th_b5388009 ; http://hdl.handle.net/10722/222428

University of British Columbia

4. Knittel, Peter. Studies on mycophenolic acid and lignan chemistry .

Degree: 1971, University of British Columbia

URL: http://hdl.handle.net/2429/34135

► Previous work on the biosynthesis of mycophenolic acid is discussed. [1’-¹⁴C]-Orsellinic acid (22) and [1'-¹⁴C]-2,4-dihydroxy-5,6-dimethylbenzoic acid (23) were synthesized and administered to Penicillium brevi-compactum. The… (more)

Subjects/Keywords: Mycophenolic acid; Lignans

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APA (6^th Edition):

Knittel, P. (1971). Studies on mycophenolic acid and lignan chemistry . (Thesis). University of British Columbia. Retrieved from http://hdl.handle.net/2429/34135

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Knittel, Peter. “Studies on mycophenolic acid and lignan chemistry .” 1971. Thesis, University of British Columbia. Accessed December 07, 2019. http://hdl.handle.net/2429/34135.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Knittel, Peter. “Studies on mycophenolic acid and lignan chemistry .” 1971. Web. 07 Dec 2019.

Vancouver:

Knittel P. Studies on mycophenolic acid and lignan chemistry . [Internet] [Thesis]. University of British Columbia; 1971. [cited 2019 Dec 07]. Available from: http://hdl.handle.net/2429/34135.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Knittel P. Studies on mycophenolic acid and lignan chemistry . [Thesis]. University of British Columbia; 1971. Available from: http://hdl.handle.net/2429/34135

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Minnesota

5. Okour, Malek. The Pharmacokinetics Of Enterohepatic Circulation.

Degree: PhD, Experimental & Clinical Pharmacology, 2015, University of Minnesota

URL: http://hdl.handle.net/11299/182173

► The EnteroHepatic Circulation (EHC) is defined as a process that is composed of a circuit of several steps including: liver metabolism, bile secretion, gut metabolism,… (more)

Subjects/Keywords: Enterohepatic; Modeling; Mycophenolic acid; NONMEM; Pharmacokinetic; Pharmacology

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APA (6^th Edition):

Okour, M. (2015). The Pharmacokinetics Of Enterohepatic Circulation. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/182173

Chicago Manual of Style (16^th Edition):

Okour, Malek. “The Pharmacokinetics Of Enterohepatic Circulation.” 2015. Doctoral Dissertation, University of Minnesota. Accessed December 07, 2019. http://hdl.handle.net/11299/182173.

MLA Handbook (7^th Edition):

Okour, Malek. “The Pharmacokinetics Of Enterohepatic Circulation.” 2015. Web. 07 Dec 2019.

Vancouver:

Okour M. The Pharmacokinetics Of Enterohepatic Circulation. [Internet] [Doctoral dissertation]. University of Minnesota; 2015. [cited 2019 Dec 07]. Available from: http://hdl.handle.net/11299/182173.

Council of Science Editors:

Okour M. The Pharmacokinetics Of Enterohepatic Circulation. [Doctoral Dissertation]. University of Minnesota; 2015. Available from: http://hdl.handle.net/11299/182173

6. Aguiar, Renata Genaro. Estudo eletrofisiológico dos efeitos da injeção intravítrea de ácido micofenólico (mpa) na retina de coelhos.

Degree: Mestrado, Neurociências e Comportamento, 2011, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/47/47135/tde-30052012-162044/ ;

►

O presente trabalho utilizou o eletrorretinograma (ERG) em coelhos (Oryctolagus cuniculus) para avaliar uma forma alternativa de aplicação do ácido micofenólico no tratamento da uveíte,… (more)

▼

O presente trabalho utilizou o eletrorretinograma (ERG) em coelhos (Oryctolagus cuniculus) para avaliar uma forma alternativa de aplicação do ácido micofenólico no tratamento da uveíte, uma doença ocular inflamatória. Uveíte é o termo utilizado para definir a inflamação da íris, coróide e corpo ciliar. O ERG é um registro de potenciais elétricos originados na retina em resposta à estimulação luminosa. O objetivo desse estudo é analisar alterações em funções da retina em olhos tratados com diferentes doses intravítreas de ácido micofenólico. Foram medidas amplitude e latência das ondas a e b do ERG para a função de intensidade-resposta e de resolução temporal. O micofenolato de mofetila (MMF) é um potente medicamento imunossupressor e vem sendo empregado com sucesso no tratamento de uveítes. O MMF é uma pró-droga, que é transformada no fígado em ácido micofenólico (MPA), o imunossupressor ativo. O uso de MMF causa efeitos colaterais e, para diminuir esses efeitos, este estudo analisa a injeção intravítea de MPA em coelhos. Foram utilizados um total de quarenta animais, divididos em seis grupos. Primeiramente, foram realizados exames eletrorretinográficos em olhos intactos, sem administração de nenhuma substância, para determinação dos parâmetros dos registros. Foram testados também os olhos injetados apenas com solução salina balanceada (SSB). Após essa etapa, foram feitos testes com olhos injetados apenas com o veículo (Polissorbato 80). Esse procedimento foi necessário para estabelecer se o veículo pode ser utilizado ou se apresenta algum grau de toxicidade para a retina. As doses usadas para avaliação da toxicidade da droga foram cinco: 5 g/ml, 50 g/ml, 200 g/ml, 1.000 g/ml e 10.000 g/ml. Os exames eletrorretinográficos foram realizados 7 e 30 dias após injeção intravítrea de MPA. Os resultados indicam que não houve alteração nos parâmetros de ERG nos olhos que receberam apenas o veículo. Também não acusaram indícios de toxicidade os olhos tratados com as doses de 5, 50 e 200 g/ml da droga. Apenas com as doses mais altas, de 1.000 e 10.000 g/ml, os olhos apresentaram diminuição de sensibilidade ao estímulo luminoso. Não é possível afirmar que as células da retina não foram danificadas pela injeção intravítrea de MPA, pois o ERG de campo total não detecta lesões pontuais. O pequeno número de olhos analisados e a necessidade de utilização de anestésicos podem levar a interpretações equivocadas dos resultados. As substâncias anestésicas podem afetar a neurotransmissão e, consequentemente, os resultados obtidos nos registros do ERG. As análises dos dados de amplitude e tempo implícito das ondas a e b foram muito consistentes e apresentam variações compatíveis com a literatura

This work uses the application of the electroretinogram (ERG) in rabbits (Oryctolagus cuniculus) in order to evaluate an alternative way of using the mycophenolic acid for treatment of uveitis, an inflammatory eye disease. Uveitis is an inflammation of the iris, choroid and ciliary body. The ERG is the record of electrical responses originated…

Advisors/Committee Members: Ventura, Dora Selma Fix.

Subjects/Keywords: Ácido micofenólico; Coelhos; Electroretinography; Eletrorretinografia; Mycophenolic acid; Rabbits; Retina; Retina; Toxicidade; Toxicity; Uveíte; Uveitis

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APA (6^th Edition):

Aguiar, R. G. (2011). Estudo eletrofisiológico dos efeitos da injeção intravítrea de ácido micofenólico (mpa) na retina de coelhos. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/47/47135/tde-30052012-162044/ ;

Chicago Manual of Style (16^th Edition):

Aguiar, Renata Genaro. “Estudo eletrofisiológico dos efeitos da injeção intravítrea de ácido micofenólico (mpa) na retina de coelhos.” 2011. Masters Thesis, University of São Paulo. Accessed December 07, 2019. http://www.teses.usp.br/teses/disponiveis/47/47135/tde-30052012-162044/ ;.

MLA Handbook (7^th Edition):

Aguiar, Renata Genaro. “Estudo eletrofisiológico dos efeitos da injeção intravítrea de ácido micofenólico (mpa) na retina de coelhos.” 2011. Web. 07 Dec 2019.

Vancouver:

Aguiar RG. Estudo eletrofisiológico dos efeitos da injeção intravítrea de ácido micofenólico (mpa) na retina de coelhos. [Internet] [Masters thesis]. University of São Paulo; 2011. [cited 2019 Dec 07]. Available from: http://www.teses.usp.br/teses/disponiveis/47/47135/tde-30052012-162044/ ;.

Council of Science Editors:

Aguiar RG. Estudo eletrofisiológico dos efeitos da injeção intravítrea de ácido micofenólico (mpa) na retina de coelhos. [Masters Thesis]. University of São Paulo; 2011. Available from: http://www.teses.usp.br/teses/disponiveis/47/47135/tde-30052012-162044/ ;

Erasmus University Rotterdam

7. Dang, Wen. Development of antivirals against norovirus: linking the bench to the bedside.

Degree: 2018, Erasmus University Rotterdam

URL: http://hdl.handle.net/1765/110021

► textabstractEven though norovirus gastroenteritis is normally self-limiting among immunocompetent individuals, it causes severe complications and fatal outcomes in immunocompromised patients. Hence novel and specific antiviral… (more)

Subjects/Keywords: Norovirus; transplantation; mycophenolic acid; interferon; nitazoxanide

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APA (6^th Edition):

Dang, W. (2018). Development of antivirals against norovirus: linking the bench to the bedside. (Doctoral Dissertation). Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/110021

Chicago Manual of Style (16^th Edition):

Dang, Wen. “Development of antivirals against norovirus: linking the bench to the bedside.” 2018. Doctoral Dissertation, Erasmus University Rotterdam. Accessed December 07, 2019. http://hdl.handle.net/1765/110021.

MLA Handbook (7^th Edition):

Dang, Wen. “Development of antivirals against norovirus: linking the bench to the bedside.” 2018. Web. 07 Dec 2019.

Vancouver:

Dang W. Development of antivirals against norovirus: linking the bench to the bedside. [Internet] [Doctoral dissertation]. Erasmus University Rotterdam; 2018. [cited 2019 Dec 07]. Available from: http://hdl.handle.net/1765/110021.

Council of Science Editors:

Dang W. Development of antivirals against norovirus: linking the bench to the bedside. [Doctoral Dissertation]. Erasmus University Rotterdam; 2018. Available from: http://hdl.handle.net/1765/110021

Indian Institute of Science

8. Hariprakasha, H K. Synthesis Of Natural Products Based On Cyclohexadienes.

Degree: 1996, Indian Institute of Science

URL: http://hdl.handle.net/2005/118

► The thesis entitled "Synthesis of Natural Products Based on Cyclohexadienes" consists of two chapters. Chapter 1 is divided into two parts. Part I gives a… (more)

Subjects/Keywords: Organic Chemistry; Mycophenolic acid; Cyclohexadienes; Phthalides; Polyketides

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APA (6^th Edition):

Hariprakasha, H. K. (1996). Synthesis Of Natural Products Based On Cyclohexadienes. (Thesis). Indian Institute of Science. Retrieved from http://hdl.handle.net/2005/118

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hariprakasha, H K. “Synthesis Of Natural Products Based On Cyclohexadienes.” 1996. Thesis, Indian Institute of Science. Accessed December 07, 2019. http://hdl.handle.net/2005/118.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hariprakasha, H K. “Synthesis Of Natural Products Based On Cyclohexadienes.” 1996. Web. 07 Dec 2019.

Vancouver:

Hariprakasha HK. Synthesis Of Natural Products Based On Cyclohexadienes. [Internet] [Thesis]. Indian Institute of Science; 1996. [cited 2019 Dec 07]. Available from: http://hdl.handle.net/2005/118.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hariprakasha HK. Synthesis Of Natural Products Based On Cyclohexadienes. [Thesis]. Indian Institute of Science; 1996. Available from: http://hdl.handle.net/2005/118

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

9. Mok, Ka-yi. Antiviral activity of mycophenolic acid against influenza viruses and MERS coronavirus.

Degree: M. Phil., 2014, University of Hong Kong

URL: http://hdl.handle.net/10722/208557

abstract

Microbiology

Master

Master of Philosophy

Subjects/Keywords: Mycophenolic acid; Influenza - Treatment; Coronavirus infections - Treatment

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APA (6^th Edition):

Mok, K. (2014). Antiviral activity of mycophenolic acid against influenza viruses and MERS coronavirus. (Masters Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/208557

Chicago Manual of Style (16^th Edition):

Mok, Ka-yi. “Antiviral activity of mycophenolic acid against influenza viruses and MERS coronavirus.” 2014. Masters Thesis, University of Hong Kong. Accessed December 07, 2019. http://hdl.handle.net/10722/208557.

MLA Handbook (7^th Edition):

Mok, Ka-yi. “Antiviral activity of mycophenolic acid against influenza viruses and MERS coronavirus.” 2014. Web. 07 Dec 2019.

Vancouver:

Mok K. Antiviral activity of mycophenolic acid against influenza viruses and MERS coronavirus. [Internet] [Masters thesis]. University of Hong Kong; 2014. [cited 2019 Dec 07]. Available from: http://hdl.handle.net/10722/208557.

Council of Science Editors:

Mok K. Antiviral activity of mycophenolic acid against influenza viruses and MERS coronavirus. [Masters Thesis]. University of Hong Kong; 2014. Available from: http://hdl.handle.net/10722/208557

10. NWAY NWAY AYE. Pharmacokinetic and pharmacodynamic studies of mycophenolic acid in renal transplant recipients.

Degree: 2009, National University of Singapore

URL: http://scholarbank.nus.edu.sg/handle/10635/16705

Subjects/Keywords: pharmacokinetic; pharmacodynamic; mycophenolate mofetil; mycophenolic acid; modeling

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APA (6^th Edition):

AYE, N. N. (2009). Pharmacokinetic and pharmacodynamic studies of mycophenolic acid in renal transplant recipients. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/16705

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

AYE, NWAY NWAY. “Pharmacokinetic and pharmacodynamic studies of mycophenolic acid in renal transplant recipients.” 2009. Thesis, National University of Singapore. Accessed December 07, 2019. http://scholarbank.nus.edu.sg/handle/10635/16705.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

AYE, NWAY NWAY. “Pharmacokinetic and pharmacodynamic studies of mycophenolic acid in renal transplant recipients.” 2009. Web. 07 Dec 2019.

Vancouver:

AYE NN. Pharmacokinetic and pharmacodynamic studies of mycophenolic acid in renal transplant recipients. [Internet] [Thesis]. National University of Singapore; 2009. [cited 2019 Dec 07]. Available from: http://scholarbank.nus.edu.sg/handle/10635/16705.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

AYE NN. Pharmacokinetic and pharmacodynamic studies of mycophenolic acid in renal transplant recipients. [Thesis]. National University of Singapore; 2009. Available from: http://scholarbank.nus.edu.sg/handle/10635/16705

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

11. YAU WAI PING. Pharmacokinetics and pharmacogenetics of mycophenolic acid in Asian renal transplant patients in Singapore.

Degree: 2008, National University of Singapore

URL: http://scholarbank.nus.edu.sg/handle/10635/28302

Subjects/Keywords: Pharmacokinetics; Pharmacogenetics; Mycophenolic acid; Asian; Renal transplant

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

PING, Y. W. (2008). Pharmacokinetics and pharmacogenetics of mycophenolic acid in Asian renal transplant patients in Singapore. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/28302

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

PING, YAU WAI. “Pharmacokinetics and pharmacogenetics of mycophenolic acid in Asian renal transplant patients in Singapore.” 2008. Thesis, National University of Singapore. Accessed December 07, 2019. http://scholarbank.nus.edu.sg/handle/10635/28302.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

PING, YAU WAI. “Pharmacokinetics and pharmacogenetics of mycophenolic acid in Asian renal transplant patients in Singapore.” 2008. Web. 07 Dec 2019.

Vancouver:

PING YW. Pharmacokinetics and pharmacogenetics of mycophenolic acid in Asian renal transplant patients in Singapore. [Internet] [Thesis]. National University of Singapore; 2008. [cited 2019 Dec 07]. Available from: http://scholarbank.nus.edu.sg/handle/10635/28302.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

PING YW. Pharmacokinetics and pharmacogenetics of mycophenolic acid in Asian renal transplant patients in Singapore. [Thesis]. National University of Singapore; 2008. Available from: http://scholarbank.nus.edu.sg/handle/10635/28302

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université Paris-Sud – Paris XI

12. Barau, Caroline. Etude des facteurs influençant la pharmacocinétique de deux médicaments glucuronoconjugués, l'acide mycophénolique et le raltégravir : Factors involved in the pharmacokinetic variability in two glucuronidated drugs, mycophenolic acid and raltegravir.

Degree: Docteur es, Pharmacologie expérimentale et clinique, 2012, Université Paris-Sud – Paris XI

URL: http://www.theses.fr/2012PA114817

►

La variabilité pharmacocinétique liée à une élimination des médicaments par glucuronoconjugaison a été peu étudiée. Nous avons donc choisi d’étudier les caractéristiques pharmacocinétiques de deux… (more)

▼

La variabilité pharmacocinétique liée à une élimination des médicaments par glucuronoconjugaison a été peu étudiée. Nous avons donc choisi d’étudier les caractéristiques pharmacocinétiques de deux médicaments glucuronoconjugués, l’acide mycophénolique (MPA, prodrogue, mycophénolate mofétil ou MMF) et le raltégravir, dans certaines situations cliniques spécifiques. Deux études cliniques ont été réalisées avec le MMF. En transplantation hépatique pédiatrique, des AUC0-12 de MPA supérieures à 30 mg.h/L ont été obtenues chez tous les enfants avec une dose de 600 mg/m² de MMF administrée par voie orale deux fois par jour. L’estimation de l’AUC0-12 par méthode non compartimentale étant particulièrement contraignante en pédiatrie, nous avons développé une stratégie de prélèvements limités permettant une estimation à partir de seulement trois prélèvements. Chez des patients adultes transplantés rénaux, nos travaux ont permis de caractériser le polymorphisme génétique des transporteurs ABCC2 et ABCB1 et l’albuminémie comme étant des facteurs de variabilité inter et intra-individuelle de la pharmacocinétique du MPA. Les concentrations intracellulaires moyennes de MPA dans les cellules mononuclées du sang périphérique étaient élevées et largement supérieures à la concentration de MPA inhibant 50% de l’activité de l’IMPDH. Nos premiers résultats concernant le raltégravir montrent que ses paramètres pharmacocinétiques sont caractérisés par une variabilité inter-individuelle importante chez des patients infectés par le VIH. Nous avons établi que le raltégravir ne se fixe pas du tout sur l’alpha-1-glycoprotéine acide mais se fixe à 60% sur l’albumine, cette fixation étant dépendante du pH plasmatique. Cependant, cette forte liaison du raltégravir à l’albumine n’empêche pas une bonne diffusion du médicament dans le compartiment séminal. En conclusion, les études de pharmacocinétique clinique que nous avons menées montrent que la variabilité de la pharmacocinétique de ces deux médicaments glucuronoconjugués est aussi importante que pour des médicaments métabolisés par le cytochrome P450 3A4. L’identification des facteurs de variabilité de ces médicaments contribue à l’optimisation des traitements.

Pharmacokinetic variability was poorly studied for drugs eliminated by glucuronidation. We therefore chose to study the pharmacokinetic parameters of two glucuronidated drugs, mycophenolic acid (MPA, prodrug, mycophenolate mofetil or MMF) and raltegravir, in specific clinical situations. Two clinical studies were conducted with MMF. In pediatric liver transplantation, MPA AUC0-12 above the target AUC of 30 mg.h/L were obtained in all children with a MMF dosing regimen of 600 mg/m² administered orally twice a day. As extensive AUC monitoring is laborious, especially in children, we developed a limited sampling strategy to calculate MPA AUC0-12 with only three samples. In adult renal transplantation, our work allowed us to characterize genetic polymorphism of ABCC2 and ABCB1 genes and serum albumin as factors of inter and intraindividual…

Advisors/Committee Members: Taburet, Anne-Marie (thesis director).

Subjects/Keywords: Suivi thérapeutique pharmacologique; Fixation aux protéines plasmatiques; Mycophenolic acid; Raltegravir; Pharmacokinetics; Pharmacogenetics; Therapeutic drug monitoring; Protein binding

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Barau, C. (2012). Etude des facteurs influençant la pharmacocinétique de deux médicaments glucuronoconjugués, l'acide mycophénolique et le raltégravir : Factors involved in the pharmacokinetic variability in two glucuronidated drugs, mycophenolic acid and raltegravir. (Doctoral Dissertation). Université Paris-Sud – Paris XI. Retrieved from http://www.theses.fr/2012PA114817

Chicago Manual of Style (16^th Edition):

Barau, Caroline. “Etude des facteurs influençant la pharmacocinétique de deux médicaments glucuronoconjugués, l'acide mycophénolique et le raltégravir : Factors involved in the pharmacokinetic variability in two glucuronidated drugs, mycophenolic acid and raltegravir.” 2012. Doctoral Dissertation, Université Paris-Sud – Paris XI. Accessed December 07, 2019. http://www.theses.fr/2012PA114817.

MLA Handbook (7^th Edition):

Barau, Caroline. “Etude des facteurs influençant la pharmacocinétique de deux médicaments glucuronoconjugués, l'acide mycophénolique et le raltégravir : Factors involved in the pharmacokinetic variability in two glucuronidated drugs, mycophenolic acid and raltegravir.” 2012. Web. 07 Dec 2019.

Vancouver:

Barau C. Etude des facteurs influençant la pharmacocinétique de deux médicaments glucuronoconjugués, l'acide mycophénolique et le raltégravir : Factors involved in the pharmacokinetic variability in two glucuronidated drugs, mycophenolic acid and raltegravir. [Internet] [Doctoral dissertation]. Université Paris-Sud – Paris XI; 2012. [cited 2019 Dec 07]. Available from: http://www.theses.fr/2012PA114817.

Council of Science Editors:

Barau C. Etude des facteurs influençant la pharmacocinétique de deux médicaments glucuronoconjugués, l'acide mycophénolique et le raltégravir : Factors involved in the pharmacokinetic variability in two glucuronidated drugs, mycophenolic acid and raltegravir. [Doctoral Dissertation]. Université Paris-Sud – Paris XI; 2012. Available from: http://www.theses.fr/2012PA114817

13. Romano, Paschoalina. Avaliação da biodisponibilidade de uma nova formulação de micofenolato mofetil e de um método para sua monitorização terapêutica.

Degree: Mestrado, Fisiopatologia Experimental, 2007, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5160/tde-31052007-144814/ ;

►

O Micofenolato Mofetil (MMF) é amplamente utilizado em transplantes de órgãos sólidos e tem como seu metabólito ativo o ácido micofenólico (MPA). A alta variabilidade… (more)

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O Micofenolato Mofetil (MMF) é amplamente utilizado em transplantes de órgãos sólidos e tem como seu metabólito ativo o ácido micofenólico (MPA). A alta variabilidade intra e interindividual dos níveis plasmáticos de MPA em pacientes transplantados renais que recebem a mesma dose de MMF, a combinação com diferentes imunossupressores que afetam seu metabolismo e a oscilação destes níveis com o tempo decorrido após o transplante justificam a sua monitorização. Pequenas mudanças na dose de MMF podem comprometer a eficácia terapêutica. O objetivo deste trabalho foi avaliar a farmacocinética de duas formulações de MMF. Estudouse um ensaio para a dosagem de ácido micofenólico (MPA) plasmático (EMIT® 2000, Dade Behring) e a seguir, a biodisponibilidade da nova formulação de MMF disponibilizada por Strides Arcolab (MMF-SA), comparativamente ao CellCept® em pacientes transplantados renais estáveis. A metodologia de imunoensaio enzimático (EMIT) apresenta resultados relativamente mais elevados em relação à cromatografia líquida de alta resolução, devido à reação cruzada do metabólito acil glucoronídeo de MPA (AcMPAG) com o anticorpo presente no reagente. O método é capaz de detectar não só o MPA, mas também o seu metabólito ativo AcMPAG, o que pode representar uma vantagem. Comparamos o método EMIT com cromatografia líquida de alta resolução acoplada à espectrometria de massas (LC-MS/MS) e obtivemos r2 = 0,9612. O método apresentou: sensibilidade analítica de 0,02 ± 0,0016ug/mL; limite de detecção de 0,01 ± 0,0015ug/mL; linearidade de 14,58 ± 0,3300ug/mL; coeficientes de variação, intraensaio de 2,14% - 5,09% e interensaio de 4,18% - 5,02%. A estabilidade da amostra foi de 90 dias em temperatura de -20°C. Concluiu-se que a metodologia EMIT para dosagem de MPA é de fácil execução e apresenta boa precisão analítica. Participaram do estudo de biodisponibilidade, vinte e quatro pacientes adultos, transplantados renais, que já recebiam o CellCept® em combinação com Tacrolimus (n = 14), ciclosporina (n= 7) ou sem inibidores de calcineurina (n=3). Todos recebiam prednisona. As duas drogas foram administradas em esquema cruzado, com intervalo de uma semana entre as farmacocinéticas. Neste intervalo, os pacientes continuaram recebendo CellCept®. Foram analisadas as curvas farmacocinéticas de 12 horas para cada uma das duas formulações, nas mesmas doses equimolares. As médias ± SE das medidas de concentração máxima (Cmax) e da área sob a curva (AUC), para CellCept®, não foram estatisticamente diferentes das médias ± SE para MMF-SA (11,29 ± 1,35ug/mL versus 11,05 ± 1,08ug/mL e 49,11 ± 5,15ug.h/mL versus 47,59 ± 3,99 ug.h/mL), respectivamente. Da mesma forma, o intervalo de confiança 90% de MMF-SA / CellCept® para Cmax (93,57% - 121,73%) e para AUC 0-12h (93,75% - 108,90%) ficaram dentro do intervalo de bioequivalência (80% - 125%). Concluímos que CellCept® pode ser substituído com segurança pela formulação MMF-SA genérica em pacientes transplantados renais estáveis.

Mycophenolate mofetil (MMF) is largely used in solid organ…

Advisors/Committee Members: David Neto, Elias.

Subjects/Keywords: Ácido micofenólico; Biological availability; Disponibilidade biológica; Drug monitoring; Equivalência terapêutica; Farmacocinética; Immunoenzyme techniques.; Kidney transplantation; Monitoramento de medicamentos; Mycophenolic acid; Pharmacokinetics; Therapeutic equivalence; Transplante de rim e técnicas imunoenzimáticas

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Romano, P. (2007). Avaliação da biodisponibilidade de uma nova formulação de micofenolato mofetil e de um método para sua monitorização terapêutica. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5160/tde-31052007-144814/ ;

Chicago Manual of Style (16^th Edition):

Romano, Paschoalina. “Avaliação da biodisponibilidade de uma nova formulação de micofenolato mofetil e de um método para sua monitorização terapêutica.” 2007. Masters Thesis, University of São Paulo. Accessed December 07, 2019. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-31052007-144814/ ;.

MLA Handbook (7^th Edition):

Romano, Paschoalina. “Avaliação da biodisponibilidade de uma nova formulação de micofenolato mofetil e de um método para sua monitorização terapêutica.” 2007. Web. 07 Dec 2019.

Vancouver:

Romano P. Avaliação da biodisponibilidade de uma nova formulação de micofenolato mofetil e de um método para sua monitorização terapêutica. [Internet] [Masters thesis]. University of São Paulo; 2007. [cited 2019 Dec 07]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5160/tde-31052007-144814/ ;.

Council of Science Editors:

Romano P. Avaliação da biodisponibilidade de uma nova formulação de micofenolato mofetil e de um método para sua monitorização terapêutica. [Masters Thesis]. University of São Paulo; 2007. Available from: http://www.teses.usp.br/teses/disponiveis/5/5160/tde-31052007-144814/ ;

14. Romano, Patrícia. Avaliação de risco informatizado e prevenção primária na assistência à saúde das mulheres da cidade de São Paulo.

Degree: Mestrado, Obstetrícia e Ginecologia, 2007, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-31052007-163435/ ;

►

Introdução: O Programa Global de Avaliação de Risco Informatizado - PAISM, através de um questionário com 91 perguntas, permite prever o risco de 9 grupos… (more)

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Introdução: O Programa Global de Avaliação de Risco Informatizado - PAISM, através de um questionário com 91 perguntas, permite prever o risco de 9 grupos importantes de doenças, que afetam as mulheres. O Programa examinou 15.538 mulheres determinando o risco para: câncer de mama, endométrio, colo de útero, ovário e pulmão; osteoporose; endometriose; DST/AIDS e dislipidemias e foram classificadas em baixo, médio e alto risco para estas doenças. Baseado no risco de avaliação, o programa ofereceu para as mulheres conselho individualizado com relação a hábitos e comportamentos. Objetivos: Avaliar os fatores sócio-demográficos, de acordo com diferentes grupos de risco para cada doença; o estilo e hábitos de vida para os riscos de determinadas doenças e o conhecimento da importância da educação para a saúde, o desempenho e a aceitação do programa. Pacientes e Métodos: Foram estudadas retrospectivamente 320 mulheres selecionadas, sem critérios previamente estabelecidos apenas com a condição de ter participado do Programa Global de Avaliação de Risco Informatizado e não ter câncer. A coleta de dados foi realizada a partir de um outro questionário, constituído de 30 questões que foi aplicado no Ambulatório de Ginecologia do Hospital das Clínicas da FMUSP e em ações existentes nas comunidades carentes da região da Cidade de São Paulo. Esta pesquisa foi delineada inicialmente com base em um modelo conceitual-operativo de natureza quantitativa e, posteriormente, qualitativa. Resultados e conclusões: Existem fatores sócio-demográficos e as variáveis atitudinais, que demonstram o estilo de vida da paciente, também, traçam os grupos de alto risco e colaboram para a observação de determinadas doenças. O nível de conscientização das entrevistadas em relação a algumas variáveis de risco é alto, no entanto, essa conscientização nem sempre se reflete em atitudes e esses fatores acabam influenciando o alto risco nas doenças pesquisadas. As entrevistadas afirmam: o programa é bom, o questionário de avaliação é fácil, a interpretação do risco e as orientações de qualidade de vida são muito boas, demonstrando a importância da educação para a saúde.

Introduction: The Global Program of Evaluation of Informed Risks - GPEIR, through one questionnaire with 91 questions, allows foresee the risk of 9 important groups of disease, which affects women. The Program examined 15.538 women determining the risk to: breast cancer, endometrium, uterus col, ovarian and lung; osteoporosis, endometriosis; DST/AIDS and dislipidemias and were classified below, medium and high risk to those illnesses. Based on the risk of the evaluation, this program offered to women individual advises related to habits and behavior. Objectives: Evaluate the socio-demographic factors, in agreement with different groups of risks to each illness; the stile and habits of life to risks of determined illness and the knowledge of the importance of education to healthy, development and acceptation of the program. Patients and methods: 320 women selected had been studied, without…

Advisors/Committee Members: Fonseca, Angela Maggio da.

Subjects/Keywords: Ácido micofenólico/farmacocinética; Biological availability; Disponibilidade biológica; Drug monitoring; Equivalência terapêutica; Immunoenzyme techniques; Kidney transplantation; Monitoramento de medicamentos; Mycophenolic acid/pharmacokinetics; Técnicas imunoenzimáticas; Therapeutic equivalency; Transplante de rim

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Romano, P. (2007). Avaliação de risco informatizado e prevenção primária na assistência à saúde das mulheres da cidade de São Paulo. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5139/tde-31052007-163435/ ;

Chicago Manual of Style (16^th Edition):

Romano, Patrícia. “Avaliação de risco informatizado e prevenção primária na assistência à saúde das mulheres da cidade de São Paulo.” 2007. Masters Thesis, University of São Paulo. Accessed December 07, 2019. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-31052007-163435/ ;.

MLA Handbook (7^th Edition):

Romano, Patrícia. “Avaliação de risco informatizado e prevenção primária na assistência à saúde das mulheres da cidade de São Paulo.” 2007. Web. 07 Dec 2019.

Vancouver:

Romano P. Avaliação de risco informatizado e prevenção primária na assistência à saúde das mulheres da cidade de São Paulo. [Internet] [Masters thesis]. University of São Paulo; 2007. [cited 2019 Dec 07]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-31052007-163435/ ;.

Council of Science Editors:

Romano P. Avaliação de risco informatizado e prevenção primária na assistência à saúde das mulheres da cidade de São Paulo. [Masters Thesis]. University of São Paulo; 2007. Available from: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-31052007-163435/ ;

15. Gasparin, Fabio. Estudo farmacológico, eletrofisiológico e morfológico dos efeitos da injeção intravítrea de ácido micofenólico em coelhos.

Degree: PhD, Oftalmologia, 2013, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5149/tde-24062013-153022/ ;

► INTRODUÇÃO: O micofenolato de mofetila é uma droga imunomoduladora utilizada no tratamento de uveítes crônicas não infecciosas. No entanto, até 20% dos pacientes interrompem o… (more)

▼ INTRODUÇÃO: O micofenolato de mofetila é uma droga imunomoduladora utilizada no tratamento de uveítes crônicas não infecciosas. No entanto, até 20% dos pacientes interrompem o tratamento devido aos efeitos colaterais sistêmicos. O ácido micofenólico é a droga ativa do micofenolato de mofetila e sua aplicação na cavidade vítrea pode ser uma alternativa complementar ao tratamento sistêmico. Entretanto, deve-se considerar o risco de efeitos tóxicos da droga na retina e em outras estruturas oculares. OBJETIVOS: Determinar a meia-vida do ácido micofenólico no vítreo de coelhos e avaliar os efeitos retinianos causados pela injeção intravítrea de diferentes doses de MPA através de avaliações clínica, funcional e morfológica. MÉTODOS: Para o estudo farmacológico, a suspensão de ácido micofenólico (1 mg em 0,1 mL de veículo) foi injetada no vítreo de 16 coelhos albinos New Zealand. Como controle, o olho contralateral de cada coelho foi injetado com 0,1 mL do veículo usado na preparação da suspensão. Os animais foram sacrificados após 1, 7, 15 e 30 dias e as concentrações de ácido micofenólico no vítreo e no sangue foram determinadas por cromatografia líquida de alta eficiência. Para a determinação dos efeitos retinianos do ácido micofenólico foram utilizados 20 coelhos albinos New Zealand, que foram divididos em 5 grupos com quatro animais em cada grupo. Cada animal recebeu injeção de 0,005, 0,05, 0,2, 1 e 10 mg de ácido micofenólico em 0,1 mL de veículo no olho direito e 0,1 mL do veículo no olho esquerdo. Exames de biomicroscopia com lâmpada de fenda e oftalmoscopia binocular indireta foram realizados antes da injeção e 30 dias após. A avaliação funcional da retina foi feita por eletrorretinografia, que foi realizada antes e 7, 15 e 30 dias após a injeção. Os animais foram sacrificados 30 dias após as injeções intravítreas e a avaliação histológica foi feita por microscopia de luz (hematoxilina-eosina). RESULTADOS: A meia-vida do ácido micofenólico no vítreo do coelho foi de 5,0±0,3 dias e o ácido micofenólico foi detectável no vítreo por 29 dias. O ácido micofenólico não foi detectado no vítreo do olho contralateral e no sangue em nenhum tempo estudado. Sinais inflamatórios de pouca intensidade foram observados em pelo menos um olho de cada grupo e não tiveram relação com a dose de ácido micofenólico injetada. A análise da eletrorretinografia não mostrou diferenças significativas da amplitude e tempo implícito da onda-a e da onda-b nas condições escotópica e fotópica após a injeção intravítrea nos cinco grupos avaliados. A análise da relação entre a amplitude da onda-b versus intensidade do estímulo luminoso mostrou diminuição da sensibilidade retiniana após a injeção intravítrea do ácido micofenólico nas doses de 0,05, 0,2, 1 e 10 mg. O estudo histológico não mostrou alterações estruturais da retina após a injeção intravítrea de ácido micofenólico nas cinco doses avaliadas. CONCLUSÕES: O ácido micofenólico tem meia-vida de 5 dias e foi detectável no vítreo de coelhos até 29 dias após a injeção intravítrea. A avaliação… Advisors/Committee Members: Damico, Francisco Max.

Subjects/Keywords: Ácido micofenólico; Coelhos; Drug toxicity; Electroretinography; Eletrorretinografia; Farmacocinética; Injeções intravítreas; Intravitreal injections; Mycophenolic acid; Pharmacology; Rabbits; Retina; Retina; Toxicidade de drogas; Uveíte; Uveitis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gasparin, F. (2013). Estudo farmacológico, eletrofisiológico e morfológico dos efeitos da injeção intravítrea de ácido micofenólico em coelhos. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5149/tde-24062013-153022/ ;

Chicago Manual of Style (16^th Edition):

Gasparin, Fabio. “Estudo farmacológico, eletrofisiológico e morfológico dos efeitos da injeção intravítrea de ácido micofenólico em coelhos.” 2013. Doctoral Dissertation, University of São Paulo. Accessed December 07, 2019. http://www.teses.usp.br/teses/disponiveis/5/5149/tde-24062013-153022/ ;.

MLA Handbook (7^th Edition):

Gasparin, Fabio. “Estudo farmacológico, eletrofisiológico e morfológico dos efeitos da injeção intravítrea de ácido micofenólico em coelhos.” 2013. Web. 07 Dec 2019.

Vancouver:

Gasparin F. Estudo farmacológico, eletrofisiológico e morfológico dos efeitos da injeção intravítrea de ácido micofenólico em coelhos. [Internet] [Doctoral dissertation]. University of São Paulo; 2013. [cited 2019 Dec 07]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5149/tde-24062013-153022/ ;.

Council of Science Editors:

Gasparin F. Estudo farmacológico, eletrofisiológico e morfológico dos efeitos da injeção intravítrea de ácido micofenólico em coelhos. [Doctoral Dissertation]. University of São Paulo; 2013. Available from: http://www.teses.usp.br/teses/disponiveis/5/5149/tde-24062013-153022/ ;

16. Djabarouti, Sarah. Optimisation des traitements à base d'acide mycophénolique chez les patients atteints de maladies auto-immunes : Strategies for improving treatments with mycophenolic acid in patients with autoimmune diseases.

Degree: Docteur es, Sciences, technologie, santé. Pharmacologie, 2009, Université de Bordeaux Segalen

URL: http://www.theses.fr/2009BOR21699

►

L’acide mycophénolique (MPA) est un immunosuppresseur très prometteur dans le traitement des maladies auto-immunes (MAI) telles que le lupus érythémateux disséminé (LED) et les vascularites… (more)

▼

L’acide mycophénolique (MPA) est un immunosuppresseur très prometteur dans le traitement des maladies auto-immunes (MAI) telles que le lupus érythémateux disséminé (LED) et les vascularites à ANCA, et disponible sous deux formes pharmaceutiques : le mycophénolate mofétil (MMF) et le mycophénolate sodique (EC-MPS). Les études menées chez les patients transplantés recommandent le dosage plasmatique et le suivi pharmacocinétique (PK) du MPA, dans un objectif d’optimisation thérapeutique. A ce jour, ce suivi est encore inexistant dans les MAI, et les données de corrélation concentrations-efficacité thérapeutique, sur lesquelles se base l’optimisation, demeurent toujours rares dans ce domaine. Les travaux présentés dans cette thèse s’inscrivent dans l’étude des corrélations PK/pharmacodynamie (PD) du MPA dans les MAI. Ces travaux ont permis de proposer des schémas et des outils d’optimisation des traitements à base de MPA pour ces patients. Pour cela, les concentrations plasmatiques du MPA et de son métabolite 7-O-glucuronide (MPAG) ont été déterminées pour 53 patients présentant de manifestations extra-rénales de MAI à l’aide d’une méthode de chromatographie couplée à la spectrométrie de masse. Les paramètres PK ont été estimés pour MMF et EC-MPS dans les deux groupes de MAI. D’après ces travaux, l’optimisation du MMF chez les patients atteints de MAI peut reposer sur le suivi de la concentration à 12 h (C12) en MPA. Un seuil de 3 mg/L est proposé afin de maintenir la rémission dans le LED, mais reste à définir dans les vascularites. Pour EC-MPS, une stratégie de prélèvements limités basée sur la mesure de la concentration maximale et la C12 est nécessaire pour estimer l’aire sous la courbe des concentrations entre 0 et 12 h du MPA.

Mycophenolic acid (MPA), the active form of both mycophenolate mofetil (MMF) and enteric-coated mycophenolate sodium (EC-MPS), is an immunosuppressant increasingly used in the treatment of autoimmune diseases such as systemic lupus erythematosus (SLE) and ANCA-associated vasculitis. In transplant recipients, therapeutic drug monitoring (TDM) of MPA is widely used to prevent acute organ rejection. However, MPA TDM is currently not available in autoimmune diseases, as data on the pharmacokinetic (PK)/pharmacodynamic (PD) relationships are very sparse in this indication. Our aim was to study the possible PK/PD relationships of MPA in patients with non-renal manifestations of SLE or ANCA-associated vasculitis. An assay based on liquid chromatography coupled with mass spectrometry was applied to the PK study of MPA and its major glucuronide metabolite (MPAG) in 53 SLE and vasculitis patients receiving either MMF or EC-MPS. According to our results, in SLE patients with non-renal manifestations, TDM based on the measurement of MPA 12-h trough concentration (C12) would allow optimizing therapies with MMF. A 3-mg/L efficacy threshold could be proposed to prevent clinical flares under MMF maintenance therapy. For EC-MPS, a limited sampling strategy including MPA maximum concentration and C12 is…

Advisors/Committee Members: Saux, Marie-Claude (thesis director).

Subjects/Keywords: Acide mycophénolique; Corrélations PK/PD; Lupus érythémateux disséminé; Vascularites à ANCA; Mycophenolic acid; PK/PD relationships; Systemic lupus erythematosus; ANCA-associated vasculitis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Djabarouti, S. (2009). Optimisation des traitements à base d'acide mycophénolique chez les patients atteints de maladies auto-immunes : Strategies for improving treatments with mycophenolic acid in patients with autoimmune diseases. (Doctoral Dissertation). Université de Bordeaux Segalen. Retrieved from http://www.theses.fr/2009BOR21699

Chicago Manual of Style (16^th Edition):

Djabarouti, Sarah. “Optimisation des traitements à base d'acide mycophénolique chez les patients atteints de maladies auto-immunes : Strategies for improving treatments with mycophenolic acid in patients with autoimmune diseases.” 2009. Doctoral Dissertation, Université de Bordeaux Segalen. Accessed December 07, 2019. http://www.theses.fr/2009BOR21699.

MLA Handbook (7^th Edition):

Djabarouti, Sarah. “Optimisation des traitements à base d'acide mycophénolique chez les patients atteints de maladies auto-immunes : Strategies for improving treatments with mycophenolic acid in patients with autoimmune diseases.” 2009. Web. 07 Dec 2019.

Vancouver:

Djabarouti S. Optimisation des traitements à base d'acide mycophénolique chez les patients atteints de maladies auto-immunes : Strategies for improving treatments with mycophenolic acid in patients with autoimmune diseases. [Internet] [Doctoral dissertation]. Université de Bordeaux Segalen; 2009. [cited 2019 Dec 07]. Available from: http://www.theses.fr/2009BOR21699.

Council of Science Editors:

Djabarouti S. Optimisation des traitements à base d'acide mycophénolique chez les patients atteints de maladies auto-immunes : Strategies for improving treatments with mycophenolic acid in patients with autoimmune diseases. [Doctoral Dissertation]. Université de Bordeaux Segalen; 2009. Available from: http://www.theses.fr/2009BOR21699

17. Gillot, Guillaume. Etude de la diversité structurale et fonctionnelle au sein de l'espèce Penicillium roqueforti : Study of the structural and functional diversity within Penicillium roqueforti species.

Degree: Docteur es, Biologie-Santé.Microbiologie, 2015, Brest

URL: http://www.theses.fr/2015BRES0081

► Plusieurs espèces fongiques dites « technologiques » jouent un rôle primordial, via leurs activités métaboliques, dans le développement des caractéristiques organoleptiques et la typicité des… (more)

▼ Plusieurs espèces fongiques dites « technologiques » jouent un rôle primordial, via leurs activités métaboliques, dans le développement des caractéristiques organoleptiques et la typicité des fromages. Cependant, malgré une utilisation et une consommation ancestrale, un manque de connaissances persiste que ce soit aux niveaux génétique ou fonctionnel concernant certaines de ces espèces, notamment Penicillium roqueforti. Principalement utilisé dans la production de fromages à pâte persillée, c’est lors de l’affinage que P. roqueforti participe au développement des qualités organoleptiques typiques de ces fromages via, entre autres, ses activités lipolytiques et protéolytiques. Cette espèce est également caractérisée par une diversité morphologique importante, largement révélée au cours de ces travaux, et ayant donné lieu à certaines dénominations technologiques distinctes par le passé conduisant à une interrogation sur la possible existence de plusieurs espèces au sein de l’entité P. roqueforti. Dans ce contexte, une étude phylogénétique basée sur le principe de concordance généalogique (GC-PSR) a été menée sur une vaste collection mondiale de P. roqueforti en utilisant 8 loci. Cette étude a montré l’existence d’une espèce unique. La diversité intraspécifique des isolats de P. roqueforti a ensuite été évaluée en utilisant 4 marqueurs microsatellites qui ont permis de révéler l’existence de 28 haplotypes répartis en 3 populations génétiquement différenciées et corrélées à différents types de fromages à pâte persillée. Sur la base de ces résultats, 55 isolats représentatifs ont par la suite été criblés afin d’évaluer la possible existence d’un caractère haplotype-dépendant concernant les activités protéolytiques, lipolytiques et la production de métabolites secondaires volatils et non-volatils. Cette étude a permis de mettre en évidence une diversité fonctionnelle relativement importante avec, entre autres, l’identification de 52 molécules volatiles, les méthyl-cétones étant majoritaires dans le volatilome des cultures de P. roqueforti, et des profils de production de mycotoxines parfois contrastés. Cependant, une bonne corrélation a été observée entre les groupes d’isolats issus de fromages AOP ou IGP et les métabolites produits. Suite à l’observation de niveaux de productions contrastées d’acide mycophénolique retrouvées chez P. roqueforti, le cluster de gènes impliqué dans sa biosynthèse a été identifié in silico chez P. roqueforti avant que des expériences d'ARN interférence ne soient réalisées sur le gène mpaC codant une polycétide synthase. La fonctionnalité de l’ensemble du cluster a pu être confirmée par différentes approches et des comparaisons de séquences entre différentes souches ayant des productions d’acide mycophénolique contrastées ont permis de mettre en évidence une délétion de 174 pb au niveau du gène mpaC limitant cette production à des niveaux non détectables chez certaines souches. Ce dernier résultat a ainsi apporté un premier élément de réponse quant à la nature a priori souche-dépendante de la… Advisors/Committee Members: Coton, Emmanuel (thesis director).

Subjects/Keywords: P. roqueforti; Fromage; Diversité; Populations génétiques; Volatilome; Protéolyse; Mycotoxines; Acide mycophénolique; P. roqueforti; Cheese; Diversity; Genetic populations; Volatilome; Proteolysis; Mycotoxins; Mycophenolic acid; 579.565 4

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gillot, G. (2015). Etude de la diversité structurale et fonctionnelle au sein de l'espèce Penicillium roqueforti : Study of the structural and functional diversity within Penicillium roqueforti species. (Doctoral Dissertation). Brest. Retrieved from http://www.theses.fr/2015BRES0081

Chicago Manual of Style (16^th Edition):

Gillot, Guillaume. “Etude de la diversité structurale et fonctionnelle au sein de l'espèce Penicillium roqueforti : Study of the structural and functional diversity within Penicillium roqueforti species.” 2015. Doctoral Dissertation, Brest. Accessed December 07, 2019. http://www.theses.fr/2015BRES0081.

MLA Handbook (7^th Edition):

Gillot, Guillaume. “Etude de la diversité structurale et fonctionnelle au sein de l'espèce Penicillium roqueforti : Study of the structural and functional diversity within Penicillium roqueforti species.” 2015. Web. 07 Dec 2019.

Vancouver:

Gillot G. Etude de la diversité structurale et fonctionnelle au sein de l'espèce Penicillium roqueforti : Study of the structural and functional diversity within Penicillium roqueforti species. [Internet] [Doctoral dissertation]. Brest; 2015. [cited 2019 Dec 07]. Available from: http://www.theses.fr/2015BRES0081.

Council of Science Editors:

Gillot G. Etude de la diversité structurale et fonctionnelle au sein de l'espèce Penicillium roqueforti : Study of the structural and functional diversity within Penicillium roqueforti species. [Doctoral Dissertation]. Brest; 2015. Available from: http://www.theses.fr/2015BRES0081

18. HUO JIANXIN. Mechanisms of GTP-depletion induced apoptosis in HIT-T15 insulin-secreting cells.

Degree: 2003, National University of Singapore

URL: http://scholarbank.nus.edu.sg/handle/10635/13480

Subjects/Keywords: beta cell; mycophenolic acid; apoptosis; p21; caspase-2; tissue transglutaminase

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

JIANXIN, H. (2003). Mechanisms of GTP-depletion induced apoptosis in HIT-T15 insulin-secreting cells. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/13480

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

JIANXIN, HUO. “Mechanisms of GTP-depletion induced apoptosis in HIT-T15 insulin-secreting cells.” 2003. Thesis, National University of Singapore. Accessed December 07, 2019. http://scholarbank.nus.edu.sg/handle/10635/13480.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

JIANXIN, HUO. “Mechanisms of GTP-depletion induced apoptosis in HIT-T15 insulin-secreting cells.” 2003. Web. 07 Dec 2019.

Vancouver:

JIANXIN H. Mechanisms of GTP-depletion induced apoptosis in HIT-T15 insulin-secreting cells. [Internet] [Thesis]. National University of Singapore; 2003. [cited 2019 Dec 07]. Available from: http://scholarbank.nus.edu.sg/handle/10635/13480.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

JIANXIN H. Mechanisms of GTP-depletion induced apoptosis in HIT-T15 insulin-secreting cells. [Thesis]. National University of Singapore; 2003. Available from: http://scholarbank.nus.edu.sg/handle/10635/13480

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Faugaret, Delphine. Effet de l'acide mycophénolique sur les voies de signalisation activées par des agents pro-inflammatoires dans la cellule dendritique humaine : The act of the image : notes, reflexions, positions : navigate, here and there, with (or without) the mobile.

Degree: Docteur es, Sciences de la Vie et de la Santé, 2008, Université François-Rabelais de Tours

URL: http://www.theses.fr/2008TOUR3303

►

Initialement développés pour leur action inhibitrice sur les lymphocytes T, les immunosuppresseurs affectent aussi les cellules dendritiques (CD). Nous avons précédemment montré que l’acide mycophénolique… (more)

▼

Initialement développés pour leur action inhibitrice sur les lymphocytes T, les immunosuppresseurs affectent aussi les cellules dendritiques (CD). Nous avons précédemment montré que l’acide mycophénolique (MPA) induisait une résistance des CD humaines à la maturation, néanmoins son mécanisme d’action sur les CD reste méconnu. Ce travail de thèse montre que le MPA inhibe l’activation de p38MAPK et que cette propriété entraîne l’inhibition de la maturation phénotypique induite par le facteur nécrotique tumoral a (TNFa), la diminution de la sécrétion de cytokines pro-inflammatoires et de la capacité allostimulatrice induite par le TNFa ou le lipopolysaccharide suggérant que l’inhibition de la synthèse de cytokines inflammatoires serait déterminante pour inhiber la capacité allostimulatrice. Nous rapportons également que le MPA inhibe la phosphorylation de ERK induite par le TNFa. Ainsi, l’action du MPA sur les CD s’exerce différemment selon l’environnement dans lequel se trouvent les CD.

Immunosuppressive drugs, initially developed to inhibit T cell activation, are also known now to affect dendritic cell (DC) functions. Previous works from our laboratory showed that mycophenolic acid (MPA) induced a resistance to maturation in human DC, however its mechanism of action in DC, remains elusive. In this study, we found that MPA inhibited p38MAPK phosphorylation independently. This p38MAPK inhibition resulted in a decrease phenotypic maturation upon tumor necrosis factor-a (TNF-a) stimulation and in a decrease in the pro-inflammatory cytokine secretion upon either lipopolysaccharide or TNF-a activation. MPA also decreased allostimulatory ability after both stimuli suggesting that inflammatory cytokine inhibition was predominant over co-stimulation marker reduction to inhibit the DC allostimulatory ability. We also showed that MPA only inhibited the TNFa-induced ERK phosphorylation. Thus, the microenvironnement of the DC might influence its ability to response to MPA.

Advisors/Committee Members: Lebranchu, Yvon (thesis director).

Subjects/Keywords: Transplantation; Acide mycophénolique; Tolérance immune; Probiotiques; Cellule dentritique humaine; Voie de transduction; Immunosuppresseur; Makk; Dendritic cells; Mycophenolic acid

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Faugaret, D. (2008). Effet de l'acide mycophénolique sur les voies de signalisation activées par des agents pro-inflammatoires dans la cellule dendritique humaine : The act of the image : notes, reflexions, positions : navigate, here and there, with (or without) the mobile. (Doctoral Dissertation). Université François-Rabelais de Tours. Retrieved from http://www.theses.fr/2008TOUR3303

Chicago Manual of Style (16^th Edition):

Faugaret, Delphine. “Effet de l'acide mycophénolique sur les voies de signalisation activées par des agents pro-inflammatoires dans la cellule dendritique humaine : The act of the image : notes, reflexions, positions : navigate, here and there, with (or without) the mobile.” 2008. Doctoral Dissertation, Université François-Rabelais de Tours. Accessed December 07, 2019. http://www.theses.fr/2008TOUR3303.

MLA Handbook (7^th Edition):

Faugaret, Delphine. “Effet de l'acide mycophénolique sur les voies de signalisation activées par des agents pro-inflammatoires dans la cellule dendritique humaine : The act of the image : notes, reflexions, positions : navigate, here and there, with (or without) the mobile.” 2008. Web. 07 Dec 2019.

Vancouver:

Faugaret D. Effet de l'acide mycophénolique sur les voies de signalisation activées par des agents pro-inflammatoires dans la cellule dendritique humaine : The act of the image : notes, reflexions, positions : navigate, here and there, with (or without) the mobile. [Internet] [Doctoral dissertation]. Université François-Rabelais de Tours; 2008. [cited 2019 Dec 07]. Available from: http://www.theses.fr/2008TOUR3303.

Council of Science Editors:

Faugaret D. Effet de l'acide mycophénolique sur les voies de signalisation activées par des agents pro-inflammatoires dans la cellule dendritique humaine : The act of the image : notes, reflexions, positions : navigate, here and there, with (or without) the mobile. [Doctoral Dissertation]. Université François-Rabelais de Tours; 2008. Available from: http://www.theses.fr/2008TOUR3303

20. Lemoine, Roxane. Propriétés régulatrices des cellules dendritiques humaines traitées par l’acide mycophénolique : Regulatory properties of human dendritic cells treated by mycophenolic acid.

Degree: Docteur es, Sciences de la Vie et de la Santé, 2009, Université François-Rabelais de Tours

URL: http://www.theses.fr/2009TOUR3138

►

En transplantation d’organes, la réponse immunitaire de l’hôte contre son donneur reste une cause très importante de perte de greffons. Ainsi, un meilleur contrôle de… (more)

▼

En transplantation d’organes, la réponse immunitaire de l’hôte contre son donneur reste une cause très importante de perte de greffons. Ainsi, un meilleur contrôle de la réponse par induction d’une tolérance spécifique reste une priorité en transplantation humaine. Dans ce travail, nous avons exploré les effets de l’acide mycophénolique (MPA, immunosuppresseur couramment utilisé en transplantation) sur les cellules dendritiques (DC) humaines. Nous avons mis en évidence que le MPA diminue la capacité des DC à activer des lymphocytes T CD8+ cytotoxiques allogéniques en diminuant la synthèse d’interféron gamma dans les DC. Par ailleurs, les DC traitées par MPA sont capables d’induire des lymphocytes T CD4+ régulateurs antigène-spécifiques (iTreg) qui peuvent reprogrammer des DC matures en DC aux propriétés tolérogènes. Enfin, ces iTreg entraînent une réduction de la sécrétion d’IFN-γ par les cellules T CD8+ et une inhibition de leur fonction cytotoxique en réponse à une stimulation allogénique. L’ensemble de ces résultats obtenus in vitro suggèrent que les DC-MPA humaines pourraient être potentiellement utilisés en thérapie cellulaire afin de promouvoir une tolérance d’allogreffe.

In organ transplantation, host immune response against donor still remains a major cause of graft loss. A better control of allogeneic response through the induction of specific tolerance is a major goal in human transplantation. In this work, we explored the effects of mycophenolic acid (MPA, an immunosuppressive drug currently used in transplantation) on dendritic cell (DC) functions. We demonstrated that MPA inhibits DC ability to induce allogeneic cytotoxic CD8+ T cells through inhibition of interferon gamma synthesis in DC. Moreover, mycophenolic acid-treated dendritic cells (MPA-DC) are able to induce antigen-specific regulatory CD4+ T lymphocytes (iTreg) which can convert fully mature DC into tolerogenic DC. These iTreg decrease the expression of proteins associated with cytotoxic function (perforin and granzymes A and B), reduce IFN-γ production by CD8+ T cells and inhibit their cytotoxic function in response to allogeneic stimulation. These results taken together suggest that human MPA-DC could be use in cellular therapy in order to promote allograft tolerance.

Advisors/Committee Members: Nivet, Hubert (thesis director).

Subjects/Keywords: Greffe d'organes; Cellules dendritiques humaines; Acide mycophénolique; Tolérance d'allogreffe; Organ transplantation; Dendritic cells; Mycophenolic acid; Allograft tolerance

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lemoine, R. (2009). Propriétés régulatrices des cellules dendritiques humaines traitées par l’acide mycophénolique : Regulatory properties of human dendritic cells treated by mycophenolic acid. (Doctoral Dissertation). Université François-Rabelais de Tours. Retrieved from http://www.theses.fr/2009TOUR3138

Chicago Manual of Style (16^th Edition):

Lemoine, Roxane. “Propriétés régulatrices des cellules dendritiques humaines traitées par l’acide mycophénolique : Regulatory properties of human dendritic cells treated by mycophenolic acid.” 2009. Doctoral Dissertation, Université François-Rabelais de Tours. Accessed December 07, 2019. http://www.theses.fr/2009TOUR3138.

MLA Handbook (7^th Edition):

Lemoine, Roxane. “Propriétés régulatrices des cellules dendritiques humaines traitées par l’acide mycophénolique : Regulatory properties of human dendritic cells treated by mycophenolic acid.” 2009. Web. 07 Dec 2019.

Vancouver:

Lemoine R. Propriétés régulatrices des cellules dendritiques humaines traitées par l’acide mycophénolique : Regulatory properties of human dendritic cells treated by mycophenolic acid. [Internet] [Doctoral dissertation]. Université François-Rabelais de Tours; 2009. [cited 2019 Dec 07]. Available from: http://www.theses.fr/2009TOUR3138.

Council of Science Editors:

Lemoine R. Propriétés régulatrices des cellules dendritiques humaines traitées par l’acide mycophénolique : Regulatory properties of human dendritic cells treated by mycophenolic acid. [Doctoral Dissertation]. Université François-Rabelais de Tours; 2009. Available from: http://www.theses.fr/2009TOUR3138

21. Araújo, Lilian Monteiro Pereira. "Co-interferências da farmacocinética dos inibidores de calcineurina em associação com micofenolato mofetil em pacientes transplantados renais".

Degree: PhD, Nefrologia, 2006, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5148/tde-13092006-155555/ ;

►

Para avaliar a exposição ao ácido micofenólico (MPA) na fase inicial pós-transplante renal, receptores foram destinados para receber tacrolimo (n=33) ou ciclosporina (n=19, controle) com… (more)

Subjects/Keywords: Ácido micofenólico; Area under curve; Áreas sob a curva; Ciclosporina; Cyclosporine; Drug monitoring; Farmacocinética; Kidney Transplantation; Monitoramento de medicamentos; Mycophenolic acid; Pharmacokinetics; Tacrolimo; Tacrolimus; Transplante de rim

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Araújo, L. M. P. (2006). "Co-interferências da farmacocinética dos inibidores de calcineurina em associação com micofenolato mofetil em pacientes transplantados renais". (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5148/tde-13092006-155555/ ;

Chicago Manual of Style (16^th Edition):

Araújo, Lilian Monteiro Pereira. “"Co-interferências da farmacocinética dos inibidores de calcineurina em associação com micofenolato mofetil em pacientes transplantados renais".” 2006. Doctoral Dissertation, University of São Paulo. Accessed December 07, 2019. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-13092006-155555/ ;.

MLA Handbook (7^th Edition):

Araújo, Lilian Monteiro Pereira. “"Co-interferências da farmacocinética dos inibidores de calcineurina em associação com micofenolato mofetil em pacientes transplantados renais".” 2006. Web. 07 Dec 2019.

Vancouver:

Araújo LMP. "Co-interferências da farmacocinética dos inibidores de calcineurina em associação com micofenolato mofetil em pacientes transplantados renais". [Internet] [Doctoral dissertation]. University of São Paulo; 2006. [cited 2019 Dec 07]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5148/tde-13092006-155555/ ;.

Council of Science Editors:

Araújo LMP. "Co-interferências da farmacocinética dos inibidores de calcineurina em associação com micofenolato mofetil em pacientes transplantados renais". [Doctoral Dissertation]. University of São Paulo; 2006. Available from: http://www.teses.usp.br/teses/disponiveis/5/5148/tde-13092006-155555/ ;

Freie Universität Berlin

22. Krämer, Stephanie. Mycophenolate mofetil slows progression in anti-Thy1-induced chronic renal fibrosis, but is not additive to a high dose of enalapril.

Degree: 2007, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-14439

► In the present work it was investigated in the animal model of anti- Thy1-induced chronic-progressive glomerulosclerosis of the rat for the first time, whether the… (more)

▼ In the present work it was investigated in the animal model of anti- Thy1-induced chronic-progressive glomerulosclerosis of the rat for the first time, whether the progression of the disease and the associated loss of renal function could be attenuated by gavage of an anti-inflammatory substance (mycophenolate mofetil, MMF), an anti-fibrotic substance (enalapril, ENA) and a combination of both substances. In the model of anti-Thy1-induced chronic glomerulosclerosis (cGS) uni-nephrectomized (NX) Wistar rats received a short- term immunological insult through i.v. injection of an antibody, which leads after a short time to a complement-dependent mesangial cell lysis. After setting this insult the renal damage progressed in a self-perpetuating, auto- progressive manner, without additional extrarenal influences, in contrast to hypertensive or diabetic nephropathies. This model allows to investigate in a unique manner purely intrarenal determinated processes, as they are taking place in the progression of chronic renal diseases. Altogether 56 rats were assigned into the following groups: a) 2-N = no cGS/ no NX/ no therapy (n=12); b) 1-N = no cGS/ NX/ no therapy (n=8); c) cGS = cGS/ NX/ no therapy (n=8); d) cGS+MMF = cGS/ NX/ MMF therapy (n=8); e) cGS+ENA = cGS/ NX/ ENA therapy (n=8); f) cGS+MMF+ENA = cGS/ NX/ MMF and ENA therapy (n=8). After a period of 15 weeks urine and blood was collected and the remained kidneys were removed after perfusion before sacrifizing the animals. For assessing renal function clinical parameters of relevancy for kidney function and representative markers for inflammation and fibrosis were determined. Therefore measurements of proteinuria (cGS 149±14 mg/ 24h: cGS+MMF 49±14; cGS+ENA 43±10; cGS+MMF+ENA 72±19), systolic blood pressure (148±8 mmHg: 126±5; 124±6; 123±4), tubulointerstitial matrix accumulation (Matrix Score 2,5±0,3: 0,9±0,3; 1,1±0,3; 1,1±0,2), tubulointerstitial expression of TGF-ß1 (189±31 pg/ mL: 91±22; 87±10; 107±21), tubulointerstitial lymphocyte (112±14,4 CD4 pos. cells/ section: 42±18,8; 45±14,7; 39±8,6) and macrophage infiltration (187±23,9 ED1-pos. cells/ section: 74±19,8; 53±16,2; 97±12,0) and levels of plasma creatinin (1,2±0,28 mg/ dL: 0,51±0,05; 0,49±0,02; 0,49±0,03) were determined. Furthermore tubulointerstitial fibronectin and PAI-1 expression on protein and mRNA levels, as well as glomerular matrixprotein accumulation, expression of TGF-ß1, fibronectin and PAI-1 on protein and mRNA levels, glomerular lymphocyte (CD4, CD8) and macrophage infiltration, blood parameters, urea and GFR were analysed. The results of these parameters are following the representative results of the elected tubulointerstitial parameters. The present study reveals, that the component MMF is similar effective in the model of anti-Thy1-induced chronic glomerulosclerosis as the clinically established golden Standard enalapril in the treatment of chronic kidney diseases and that a combined therapy could not achieve additional effects in relevant parameters characterizing chronic renal disease.… Advisors/Committee Members: n (gender), Univ.-Prof. Dr. med.vet. R. Rudolph (firstReferee), Univ.-Prof. Dr. med.vet. B. Kohn (furtherReferee), Prof. Dr. med. Harm Peters (furtherReferee).

Subjects/Keywords: Kidney Diseases; Fibrosis; Inflammation; Immunosuppressive agents; Angiotensin; Hormone antagonists; Mycophenolic Acid (MeSH); 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA (6^th Edition):

Krämer, S. (2007). Mycophenolate mofetil slows progression in anti-Thy1-induced chronic renal fibrosis, but is not additive to a high dose of enalapril. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-14439

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Krämer, Stephanie. “Mycophenolate mofetil slows progression in anti-Thy1-induced chronic renal fibrosis, but is not additive to a high dose of enalapril.” 2007. Thesis, Freie Universität Berlin. Accessed December 07, 2019. http://dx.doi.org/10.17169/refubium-14439.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Krämer, Stephanie. “Mycophenolate mofetil slows progression in anti-Thy1-induced chronic renal fibrosis, but is not additive to a high dose of enalapril.” 2007. Web. 07 Dec 2019.

Vancouver:

Krämer S. Mycophenolate mofetil slows progression in anti-Thy1-induced chronic renal fibrosis, but is not additive to a high dose of enalapril. [Internet] [Thesis]. Freie Universität Berlin; 2007. [cited 2019 Dec 07]. Available from: http://dx.doi.org/10.17169/refubium-14439.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Krämer S. Mycophenolate mofetil slows progression in anti-Thy1-induced chronic renal fibrosis, but is not additive to a high dose of enalapril. [Thesis]. Freie Universität Berlin; 2007. Available from: http://dx.doi.org/10.17169/refubium-14439

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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