subject:(Multiple sclerosis)

Oregon State University

1. Nery, Mara B. Multiple Sclerosis and Wellness : How Self-Compassion Influences Physical Activity and Health-Related Quality of Life.

Degree: PhD, Kinesiology, 2016, Oregon State University

URL: http://hdl.handle.net/1957/59833

► Multiple Sclerosis (MS) is an autoimmune condition that affects the central nervous system, and impacts the lives of over 400,000 individuals in the US. These… (more)

▼ Multiple Sclerosis (MS) is an autoimmune condition that affects the central nervous system, and impacts the lives of over 400,000 individuals in the US. These individuals face unpredictable relapses of disabling conditions, are less active and experience poorer quality of life than the general population. Health professionals are challenged to find ways to increase engagement in health promoting behaviors that can improve function and overall wellness for this population. The major objective of this dissertation was to expand the literature on promoting health behaviors and wellness through self-compassion for individuals with MS. One theoretical model that has the potential to help researchers and program developers understand how to effectively improve engagement in health behaviors for individuals with MS is Reyes’ model of self-compassion. The first aim of the first study was to cross-validate Reyes conceptual model of self-compassion among individuals with MS. Although the model is promising, recent studies suggest fatigue may play a unique role for individuals with MS. The second aim of the first study was to examine the utility of an alternative model, which expands upon Reyes’ model. Furthermore, self-compassion has been shown to improve resilience and quality of life in the general population. The second study aimed to understand the relationship between self-compassion, resilience and health-related quality of life for individuals with MS. Individuals (N = 259) participated in a survey measuring their perceived fatigue, self-compassion, psychological needs related to exercise, resilience, health-related quality of life, and self-reported physical activity, as well as a demographic questionnaire. Participants were predominately white (90%) females (84%), with a relapse-remitting MS course (73%), and a mean age of 48.60 (SD = 10.46). Study 1 validated the use of Reyes’ conceptual model of self-compassion. However, the alternative model, which added direct paths to psychological needs and fatigue, showed improved fit over Reyes’ model for this population. Results demonstrated that fatigue predicted engagement in physical activity in both models, which was expected. However, in the alternative model, fatigue significantly negatively predicted psychological needs for engaging in exercise, but showed a non-significant, weak relationship with physical activity behavior, which was unexpected. Study 2 examined the relationship between self-compassion, resilience, and health-related quality of life for individuals with MS using mediation analysis. Results from this study showed that resilience was a partial mediator between self-compassion and health-related quality of life. The results from these studies can inform future health interventions seeking to improve health-related quality of life and engagement in physical activity in this population. Both of these studies contribute to the theoretical knowledge of self-compassion, wellness, and behavior change for individuals with MS. Advisors/Committee Members: Yun, Joonkoo (advisor), Ebbeck, Vicki (committee member).

Subjects/Keywords: Multiple Sclerosis; Multiple sclerosis

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APA (6^th Edition):

Nery, M. B. (2016). Multiple Sclerosis and Wellness : How Self-Compassion Influences Physical Activity and Health-Related Quality of Life. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/59833

Chicago Manual of Style (16^th Edition):

Nery, Mara B. “Multiple Sclerosis and Wellness : How Self-Compassion Influences Physical Activity and Health-Related Quality of Life.” 2016. Doctoral Dissertation, Oregon State University. Accessed February 22, 2020. http://hdl.handle.net/1957/59833.

MLA Handbook (7^th Edition):

Nery, Mara B. “Multiple Sclerosis and Wellness : How Self-Compassion Influences Physical Activity and Health-Related Quality of Life.” 2016. Web. 22 Feb 2020.

Vancouver:

Nery MB. Multiple Sclerosis and Wellness : How Self-Compassion Influences Physical Activity and Health-Related Quality of Life. [Internet] [Doctoral dissertation]. Oregon State University; 2016. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/1957/59833.

Council of Science Editors:

Nery MB. Multiple Sclerosis and Wellness : How Self-Compassion Influences Physical Activity and Health-Related Quality of Life. [Doctoral Dissertation]. Oregon State University; 2016. Available from: http://hdl.handle.net/1957/59833

University of Georgia

2. Schik, Caroline Mary. Home-based progressive exercise training in multiple sclerosis: a pilot study.

Degree: MS, Kinesiology, 2010, University of Georgia

URL: http://purl.galileo.usg.edu/uga_etd/schik_caroline_m_201008_ms

► Clinic-based exercise is shown to enhance physical function and reduce premature disability in persons with multiple sclerosis (MS), however it isn’t always feasible. The purpose… (more)

Subjects/Keywords: Multiple Sclerosis

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APA (6^th Edition):

Schik, C. M. (2010). Home-based progressive exercise training in multiple sclerosis: a pilot study. (Masters Thesis). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/schik_caroline_m_201008_ms

Chicago Manual of Style (16^th Edition):

Schik, Caroline Mary. “Home-based progressive exercise training in multiple sclerosis: a pilot study.” 2010. Masters Thesis, University of Georgia. Accessed February 22, 2020. http://purl.galileo.usg.edu/uga_etd/schik_caroline_m_201008_ms.

MLA Handbook (7^th Edition):

Schik, Caroline Mary. “Home-based progressive exercise training in multiple sclerosis: a pilot study.” 2010. Web. 22 Feb 2020.

Vancouver:

Schik CM. Home-based progressive exercise training in multiple sclerosis: a pilot study. [Internet] [Masters thesis]. University of Georgia; 2010. [cited 2020 Feb 22]. Available from: http://purl.galileo.usg.edu/uga_etd/schik_caroline_m_201008_ms.

Council of Science Editors:

Schik CM. Home-based progressive exercise training in multiple sclerosis: a pilot study. [Masters Thesis]. University of Georgia; 2010. Available from: http://purl.galileo.usg.edu/uga_etd/schik_caroline_m_201008_ms

University of Georgia

3. Larson, Rebecca Danti. Bilateral differences in leg performance in individuals with Multiple Sclerosis: implications for fatigue and function.

Degree: PhD, Exercise Science, 2011, University of Georgia

URL: http://purl.galileo.usg.edu/uga_etd/larson_rebecca_d_201108_phd

► It is well recognized that Multiple Sclerosis (MS) can affect sides of the body asymmetrically, specifically the lower extremities; yet these disparities have not been… (more)

▼ It is well recognized that Multiple Sclerosis (MS) can affect sides of the body asymmetrically, specifically the lower extremities; yet these disparities have not been systematically examined. PUPROSE: To determine whether ambulatory individuals with mild MS would display bilateral differences in physiological and functional measures during exercise and whether these differences contribute to premature muscle fatigue. Methods. Eight individuals with relapsing remitting MS (MS) and seven non-MS individuals (controls), similar in physical characteristics completed three series of unilateral cycling tests. Participant’s legs were categorized into either stronger/less affected or weaker/more affected based on strength testing. To determine interlimb asymmetries, comparisons of submaximal fixed load ride times, VO2peak, and peak workload were performed. Unilateral exercise was performed to determine any pre-post differences in strength, mobility, and foot tap speed. Data were analyzed using paired t-tests for between-leg comparisons and independent t-tests for group differences. RESULTS: Individuals with MS exhibited significant differences (P < 0.05) in: strength (stronger leg: 95.31 ± 27.94 (lbs), weaker leg: 76.98 ± 19.60 (lbs)), submaximal fixed load ride time (stronger leg: 4.83 ± 0.33, weaker leg: 3.44 ± 1.51 min), peak oxygen uptake (stronger leg: 13.7 ± 3.2, weaker leg: 10.6 ± 3.0 ml/kg/min) and workload (watts) (stronger leg: 73.4 ± 22.3, weaker leg: 56.3 ± 26.2 watts) with no differences observed in the control group (P > 0.05). Significant differences (P < 0.05) were observed across groups for stride velocity and strength asymmetry ratios prior to unilateral exercise. Following exercise, the magnitude of asymmetry was reduced in the individuals with MS such that no differences were observed, whereas stride velocity remained slower. CONCLUSION: Ambulatory individuals with MS displayed leg asymmetry not observed in our control participants. Following unilateral exercise the MS group’s strength asymmetry scores were no longer statistically different compared to controls and the MS individuals exhibited significant reductions in stride velocity and foot tap speed. These findings provide possible insight into the consequences of fatigue on lower extremity asymmetry and function and the need for new therapeutic interventions. Advisors/Committee Members: Lesley White.

Subjects/Keywords: Multiple Sclerosis

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APA (6^th Edition):

Larson, R. D. (2011). Bilateral differences in leg performance in individuals with Multiple Sclerosis: implications for fatigue and function. (Doctoral Dissertation). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/larson_rebecca_d_201108_phd

Chicago Manual of Style (16^th Edition):

Larson, Rebecca Danti. “Bilateral differences in leg performance in individuals with Multiple Sclerosis: implications for fatigue and function.” 2011. Doctoral Dissertation, University of Georgia. Accessed February 22, 2020. http://purl.galileo.usg.edu/uga_etd/larson_rebecca_d_201108_phd.

MLA Handbook (7^th Edition):

Larson, Rebecca Danti. “Bilateral differences in leg performance in individuals with Multiple Sclerosis: implications for fatigue and function.” 2011. Web. 22 Feb 2020.

Vancouver:

Larson RD. Bilateral differences in leg performance in individuals with Multiple Sclerosis: implications for fatigue and function. [Internet] [Doctoral dissertation]. University of Georgia; 2011. [cited 2020 Feb 22]. Available from: http://purl.galileo.usg.edu/uga_etd/larson_rebecca_d_201108_phd.

Council of Science Editors:

Larson RD. Bilateral differences in leg performance in individuals with Multiple Sclerosis: implications for fatigue and function. [Doctoral Dissertation]. University of Georgia; 2011. Available from: http://purl.galileo.usg.edu/uga_etd/larson_rebecca_d_201108_phd

University of Aberdeen

4. Visser, Elizabeth Magdalena. The prevalence of multiple sclerosis in the North of Scotland.

Degree: Thesis (M.D.), 2013, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=211437 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619173

► Background: Multiple sclerosis (MS) is a common, disabling neuro-inflammatory disorder, whose prevalence seems to be increasing. Objectives: The main aims of this thesis were to:… (more)

▼ Background: Multiple sclerosis (MS) is a common, disabling neuro-inflammatory disorder, whose prevalence seems to be increasing. Objectives: The main aims of this thesis were to: (i) systematically review good quality MS prevalence studies and assess heterogeneity in prevalence rates; (ii) conduct a new prevalence study in Aberdeen, Orkney and Shetland to assess temporal trends, compare rates to other areas and describe demographic, clinical and disability data in prevalent MS patients. Methods: The systematic review used defined search strategies to identify references that satisfied inclusion criteria. The influence of time, latitude, diagnostic criteria, quality of case ascertainment and methods of classifying patients on age-gender standardised prevalence rates and sex ratios were analysed by uni- and multivariate regression. The new prevalence study identified all MS patients alive on 24/9/09 from defined general practices through multiple sources. Primary and secondary care records were used to confirm the diagnosis. Prevalence rates were standardised to 2009 Scottish population. A postal questionnaire survey was conducted to gain additional data, which allowed a randomised factorial trial of the effect of envelope colour/address labelling on response rates to be performed. Results: The review identified marked heterogeneity (I2 99.7%) in prevalence rates, partially explained by latitude (p<0.0001), prevalence date (p=0.009) and number of ascertainment sources (p=0.04). High and rising prevalence was recorded in Orkney [402/100,000 (95% CI 319-500)], the highest worldwide, Shetland [295/100,000 (95%CI 229-375)] and Aberdeen city [229/100,000 (95%CI 208-250)]. Male-to-female ratio was 1:2.55 (95%CI 2.26-2.89). Postal response rates to brown/white envelopes were not different [OR 1.17 (95% CI 0.81 to 1.68)] but hand-written address labels had a higher response than computer-generated labels [OR 1.22 (95% CI 1.06-1.40)]. Conclusions: This research showed that MS prevalence remains very high in northern Scotland and confirmed international observations of rising prevalence. Explanations include increased survival, improved diagnosis and probably increasing incidence.

Subjects/Keywords: 616.8; Multiple sclerosis

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APA (6^th Edition):

Visser, E. M. (2013). The prevalence of multiple sclerosis in the North of Scotland. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=211437 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619173

Chicago Manual of Style (16^th Edition):

Visser, Elizabeth Magdalena. “The prevalence of multiple sclerosis in the North of Scotland.” 2013. Doctoral Dissertation, University of Aberdeen. Accessed February 22, 2020. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=211437 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619173.

MLA Handbook (7^th Edition):

Visser, Elizabeth Magdalena. “The prevalence of multiple sclerosis in the North of Scotland.” 2013. Web. 22 Feb 2020.

Vancouver:

Visser EM. The prevalence of multiple sclerosis in the North of Scotland. [Internet] [Doctoral dissertation]. University of Aberdeen; 2013. [cited 2020 Feb 22]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=211437 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619173.

Council of Science Editors:

Visser EM. The prevalence of multiple sclerosis in the North of Scotland. [Doctoral Dissertation]. University of Aberdeen; 2013. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=211437 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619173

University of Utah

5. Peterson, Lisa K. Expanding the spectrum of autoimmunity induced with myelin oligodendrocyte glycoprotein.

Degree: PhD, Pathology;, 2007, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1130/rec/453

► Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. Experimental autoimmune encephalomyelitis (EAE) is an autoimmune model of MS, induced by… (more)

▼ Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. Experimental autoimmune encephalomyelitis (EAE) is an autoimmune model of MS, induced by sensitization with myelin proteins of their encephalitogenic peptides. Sensitization with amino acids 92-106 of myelin oligodendrocyte glycoprotein (MOG) induces different disease courses and neuropathology in A.SW and SJL/J mice. SJL/J mice develop a relapsing-remitting (RR-EAE) disease course characterized by mild demyelinating disease with perivascular T cell infiltration. In contrast, A.SW mice develop a progressive (P-EAE) disease course characterized by large areas of plaque-like demyelination with Ig deposition, polymorphonuclear (PMN) cell infiltration and minimal T cell infiltration and high MOG antibody titers in the serum. This thesis describes, as part of the elucidation of the role of antibody in determining disease course and neuropathology, the generation and characterization of hybridomas producing antibody reactive with MOG92-106. Two MOG92-106 hybridomas produced polyreactive IgM antibodies encoded by immunoglobulin genes in their germline configuration, indicating that the antibodies are natural autoantibodies (NAA). These MOG92-106 reactive NNA bind myelin and cause demyelination in vivo, suggesting that they could contribute to the pathogenesis of P-EAE. In addition, sensitization of A.S.W. mice with MOG92-106 or intraperitoneal injection of the MOG92-106 reactive hybridomas resulted in antibody deposition in glomeruli of kidneys and proteinuria, demonstrating that MOG92-106 reacative NAA can induce systemic autoimmunity. However, depletion of B-1 cells, the main produces of NAA, had minimal effects on the development of demyelination, antibody deposition or disease progression in mice sensitized with MOG92-106. These results indicate that while MOG92-106 reacative NAA are capable of inducing pathology in the CNS and kidneys, they play a minor role in the pathogenesis of MOG92-106-infduced EAE. In addition, this thesis describes induction of another combination of disease course and neuropathology in B10.S mice. B10.S mice have previously been considered resistant to EAE, but sensitization with MOG92-106 resulted in neuropathology in 93% of the mice and monophasic or relapsing-remitting disease course in 30% of the mice. Taken together, this work expands the spectrum of autoimmune disease that can be induced and investigated using MOG92-106.

Subjects/Keywords: Multiple Sclerosis; Antibodies

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APA (6^th Edition):

Peterson, L. K. (2007). Expanding the spectrum of autoimmunity induced with myelin oligodendrocyte glycoprotein. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1130/rec/453

Chicago Manual of Style (16^th Edition):

Peterson, Lisa K. “Expanding the spectrum of autoimmunity induced with myelin oligodendrocyte glycoprotein.” 2007. Doctoral Dissertation, University of Utah. Accessed February 22, 2020. http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1130/rec/453.

MLA Handbook (7^th Edition):

Peterson, Lisa K. “Expanding the spectrum of autoimmunity induced with myelin oligodendrocyte glycoprotein.” 2007. Web. 22 Feb 2020.

Vancouver:

Peterson LK. Expanding the spectrum of autoimmunity induced with myelin oligodendrocyte glycoprotein. [Internet] [Doctoral dissertation]. University of Utah; 2007. [cited 2020 Feb 22]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1130/rec/453.

Council of Science Editors:

Peterson LK. Expanding the spectrum of autoimmunity induced with myelin oligodendrocyte glycoprotein. [Doctoral Dissertation]. University of Utah; 2007. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1130/rec/453

Texas A&M University

6. Dean, Dana Deanna. Encapsulated interferon-tau during Theiler's virus-induced demyelinating disease: efficacy of treatment and immune response profile.

Degree: 2009, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-3113

► Multiple sclerosis (MS) is the most common primary demyelinating disease of the central nervous system in humans. Type I interferons are most frequently used to… (more)

▼ Multiple sclerosis (MS) is the most common primary demyelinating disease of the central nervous system in humans. Type I interferons are most frequently used to treat MS. However, their main mechanism of action remains elusive. Various biomarkers have been investigated for their ability to assess treatment efficacy, but results are often confounding due to differences in experimental design and variation in individual physiology. In fact, not all MS patients respond to IFN therapy and a significant number suffer severe negative side effects and must cease treatment. Thus, alternative therapeutics that offer less cytotoxicity and greater efficacy are a major objective of research. This dissertation evaluated a novel type I interferon, interferon-tau (IFNT), and its ability to attenuate Theiler?s virus-induced-demyelinating disease (TVID), a mouse model of MS. In this model, viral infection with the BeAn strain of Theiler?s murine encephalomyelitis virus (TMEV) is the initiating factor leading to demyelination of the CNS. It was hypothesized that IFNT would: 1) provide therapeutic benefit as witnessed by a stabilization of clinical score, a decrease in CNS inflammation, and a decrease in CNS demyelination, and 2) shift the immune profile from a Th1 to a Th2 response. Once mice developed chronic disability, IFNT treatment began. This novel IFN was delivered in an innovative way: encapsulation (eIFNT) in an alginate polymer, which allowed for slow and sustained release. eIFNT was delivered by a 100 ?l intraperitoneal injection (i.p.) containing 1.4M U of IFNT once every two weeks for 8 weeks. Mice were clinically scored weekly and BeAn-eIFNT mice demonstrated a decrease in clinical score. Bright field microscopy was used to evaluate CNS tissues where a decrease in demyelination and inflammation was noted in BeAn-eIFNT-treated mice. Ex vivo stimulation of virus-specific lymphocytes revealed an increase in both T helper 1 (Th1) and T helper 2 (Th2) cytokine production. Specifically, TNFA was produced at very high levels by splenocytes from BeAneIFNT mice in response to UV-inactivated BeAn alone and in the presence of IFNT when compared to BeAn-eMOPS mice under the same conditions. IFNG was produced at elevated levels from the splenocytes of BeAn-eIFNT mice versus BeAn-eMOPS mice when stimulated in vitro with UV-inactivated Bean and with BeAn in the presence of IFNT. IL-2 was produced at moderately elevated levels from the splenocytes of BeAn-eIFNT mice versus BeAn-eMOPS mice when stimulated in vitro with UV-inactivated Bean. Il-2 was elevated to a statistically significant level (p<0.05) from BeAn-eIFNT mouse splenocytes when stimulated with BeAn in the presence of IFNT when compared to BeAn-eMOPS mice and IL-10 was produced at elevated levels by splenocytes from BeAn-eIFNT mice versus that produced from BeAn-eMOPS mouse splenocytes in response to UV-inactivated BeAn alone and in the presence of IFNT. Quantification of T regulatory (Treg) cells in the spleen of eIFNT vs. eMOPS mice and blood of eIFNT vs. eMOPS mice… Advisors/Committee Members: Burghardt, Robert C. (advisor), Wesh, C. Jane (advisor), Bazer, Fuller W. (committee member), Bergman, Luc R. (committee member).

Subjects/Keywords: multiple sclerosis; interferon

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APA (6^th Edition):

Dean, D. D. (2009). Encapsulated interferon-tau during Theiler's virus-induced demyelinating disease: efficacy of treatment and immune response profile. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-3113

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dean, Dana Deanna. “Encapsulated interferon-tau during Theiler's virus-induced demyelinating disease: efficacy of treatment and immune response profile.” 2009. Thesis, Texas A&M University. Accessed February 22, 2020. http://hdl.handle.net/1969.1/ETD-TAMU-3113.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dean, Dana Deanna. “Encapsulated interferon-tau during Theiler's virus-induced demyelinating disease: efficacy of treatment and immune response profile.” 2009. Web. 22 Feb 2020.

Vancouver:

Dean DD. Encapsulated interferon-tau during Theiler's virus-induced demyelinating disease: efficacy of treatment and immune response profile. [Internet] [Thesis]. Texas A&M University; 2009. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-3113.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dean DD. Encapsulated interferon-tau during Theiler's virus-induced demyelinating disease: efficacy of treatment and immune response profile. [Thesis]. Texas A&M University; 2009. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-3113

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

7. Leung, Chieh-wing, Jervis. Development of a real-time PCR-based method for the measurement of neutralizing antibody to interferon-beta in multiple sclerosis patients.

Degree: Master of Medical Sciences, 2014, University of Hong Kong

URL: Leung, C. J. [梁倢榮]. (2014). Development of a real-time PCR-based method for the measurement of neutralizing antibody to interferon-beta in multiple sclerosis patients. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5303953 ; http://dx.doi.org/10.5353/th_b5303953 ; http://hdl.handle.net/10722/206488

► Background Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system (CNS). In Hong Kong, the prevalence rates of MS is… (more)

▼ Background Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system (CNS). In Hong Kong, the prevalence rates of MS is 4.8/100,000. First line disease modifying agent (DMA) type 1 interferon β (IFN-β) is the most commonly use therapy for relapsing and remitting MS(RRMS). Depending on the administration type and route of IFN-β, up to 80% of patients develop harmless binding antibody (BAb),which binds to IFN molecules but not necessary interfere its bioactivity. When IFN-β therapy continues, maturation of BAb response can lead to the formation of high affinity neutralizing antibody (NAb). About 45% of MS patients develop NAb against IFN-β in one year of IFN-β treatment. NAb shows a loss of IFN-β clinical effect by increasing MRI activity and disease progression. As the clinical effect of NAb is lagging behind the initial appearance of NAb in the body, it is suggested to develop a NAb assay to predict treatment failure and advice switching therapy for patients when NAb is present. Aim The aim of this study was: I. To develop and evaluate a qPCR-based method for the measurement of NAb to IFN-β in MS patient. II. To establish the normal reference range of NAb in Chinese population. III. To seek the possibility of using anti-IFN-β BAb assay and in vivo MxA gene expression assay as a screening test for NAb IV. To compare the performance between MxA induction qPCR, ELISA, WB assay and luciferase IFN-β reporter gene assay Materials and methods23Chinese RRMS patients who treated with IFN-β-1a therapy for a minimum of12 months were recruited in this study. Serum and PBMC were collected12 hours after the IFN-β-1a injection. MxA, IFNAR1 and IFNAR2 mRNA from PBMC were tested byin vivo MxA gene expression assay. NAb containing serum was tested by anti-IFN-β BAb assay, IFN-β reporter gene assay, in vitro MxA induction WB, ELISA and qPCR assay. In addition, blood samples from 3 Chinese volunteers without any known autoimmune disease history were collected to evaluate the baseline of NAb titer and MxA expression. Result The experimental condition of MxA induction qPCR assay was optimized by using 2.5×105A549 cells plating density, 10% FCS concentration,5 hours IFN-β stimulation time and GAPDH normalization. Assay accuracy was validated by reference anti-IFN-β antibody. Starting from 2.5 TRU, linear relationship could be observed (r2= 0.9873). The lower limit of quantification (LLOQ) was 0.02 LU/mL, the upper limit of quantification (ULOQ) was 16LU/mL and the limit of detection (LOD) was 0.002 LU/mL. The reproducibility of the assay was measured, the intra-and inter-assay imprecision(%CV)for high value were 5.95% and 7.17% respectively, while the intra-and inter-assay impression were8.31% and 15.95%respectively.Results of the qPCR-based method were concurring with that of luciferase IFN-β reporter gene assay. The upper limit of the NAb reference range in Chinese population was 40.3 TRU (n=3, 95% CI = 31.7-48.8). The performance observed in MxA induction ELISA assay swas…

Subjects/Keywords: Multiple sclerosis - Treatment

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APA (6^th Edition):

Leung, Chieh-wing, J. (2014). Development of a real-time PCR-based method for the measurement of neutralizing antibody to interferon-beta in multiple sclerosis patients. (Masters Thesis). University of Hong Kong. Retrieved from Leung, C. J. [梁倢榮]. (2014). Development of a real-time PCR-based method for the measurement of neutralizing antibody to interferon-beta in multiple sclerosis patients. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5303953 ; http://dx.doi.org/10.5353/th_b5303953 ; http://hdl.handle.net/10722/206488

Chicago Manual of Style (16^th Edition):

Leung, Chieh-wing, Jervis. “Development of a real-time PCR-based method for the measurement of neutralizing antibody to interferon-beta in multiple sclerosis patients.” 2014. Masters Thesis, University of Hong Kong. Accessed February 22, 2020. Leung, C. J. [梁倢榮]. (2014). Development of a real-time PCR-based method for the measurement of neutralizing antibody to interferon-beta in multiple sclerosis patients. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5303953 ; http://dx.doi.org/10.5353/th_b5303953 ; http://hdl.handle.net/10722/206488.

MLA Handbook (7^th Edition):

Leung, Chieh-wing, Jervis. “Development of a real-time PCR-based method for the measurement of neutralizing antibody to interferon-beta in multiple sclerosis patients.” 2014. Web. 22 Feb 2020.

Vancouver:

Leung, Chieh-wing J. Development of a real-time PCR-based method for the measurement of neutralizing antibody to interferon-beta in multiple sclerosis patients. [Internet] [Masters thesis]. University of Hong Kong; 2014. [cited 2020 Feb 22]. Available from: Leung, C. J. [梁倢榮]. (2014). Development of a real-time PCR-based method for the measurement of neutralizing antibody to interferon-beta in multiple sclerosis patients. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5303953 ; http://dx.doi.org/10.5353/th_b5303953 ; http://hdl.handle.net/10722/206488.

Council of Science Editors:

Leung, Chieh-wing J. Development of a real-time PCR-based method for the measurement of neutralizing antibody to interferon-beta in multiple sclerosis patients. [Masters Thesis]. University of Hong Kong; 2014. Available from: Leung, C. J. [梁倢榮]. (2014). Development of a real-time PCR-based method for the measurement of neutralizing antibody to interferon-beta in multiple sclerosis patients. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5303953 ; http://dx.doi.org/10.5353/th_b5303953 ; http://hdl.handle.net/10722/206488

University of Bridgeport

8. Fiorentino, Salvatore Jr. Safe and Effective Natural Ways to Prevent and Treat Multiple Sclerosis .

Degree: 2013, University of Bridgeport

URL: https://scholarworks.bridgeport.edu/xmlui/handle/123456789/1403

► Presently, Multiple Sclerosis is considered to be an autoimmune disorder. The myelin sheath is thought to be attacked by the body’s own immune system leading… (more)

Subjects/Keywords: Naturopathy; Multiple sclerosis

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APA (6^th Edition):

Fiorentino, S. J. (2013). Safe and Effective Natural Ways to Prevent and Treat Multiple Sclerosis . (Thesis). University of Bridgeport. Retrieved from https://scholarworks.bridgeport.edu/xmlui/handle/123456789/1403

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fiorentino, Salvatore Jr. “Safe and Effective Natural Ways to Prevent and Treat Multiple Sclerosis .” 2013. Thesis, University of Bridgeport. Accessed February 22, 2020. https://scholarworks.bridgeport.edu/xmlui/handle/123456789/1403.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fiorentino, Salvatore Jr. “Safe and Effective Natural Ways to Prevent and Treat Multiple Sclerosis .” 2013. Web. 22 Feb 2020.

Vancouver:

Fiorentino SJ. Safe and Effective Natural Ways to Prevent and Treat Multiple Sclerosis . [Internet] [Thesis]. University of Bridgeport; 2013. [cited 2020 Feb 22]. Available from: https://scholarworks.bridgeport.edu/xmlui/handle/123456789/1403.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fiorentino SJ. Safe and Effective Natural Ways to Prevent and Treat Multiple Sclerosis . [Thesis]. University of Bridgeport; 2013. Available from: https://scholarworks.bridgeport.edu/xmlui/handle/123456789/1403

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

9. Canning, Karissa L. Physical Activity and Multiple Sclerosis.

Degree: PhD, 2017, McMaster University

URL: http://hdl.handle.net/11375/22039

►

Multiple Sclerosis (MS) is an autoimmune disease characterized by demyelination and axon degeneration of the central nervous system that is accompanied by a wide range… (more)

▼

Multiple Sclerosis (MS) is an autoimmune disease characterized by demyelination and axon degeneration of the central nervous system that is accompanied by a wide range of symptoms. It is well established that physical activity is associated with a wide variety of health benefits, including improving fitness, MS-related symptoms and function in the MS population. However, despite the potential benefits associated with physical activity participation, most people living with MS remain physically inactive. In 2012, new evidence-based physical activity guidelines (PAGs) for adults with MS were released. The PAGs suggest that for health benefits, adults aged 18-64 years with mild to moderate disability need at least 30 minutes of moderate intensity aerobic physical activity two days per week and strength training for major muscle groups two times per week. The purpose of this dissertation was to determine the association between physical activity and health and to explore physical activity as a potential disease-modifying therapy in the MS population. This was completed through a series of three projects focusing on the PAGs for adults with MS. The focus of the first study of this dissertation was on the implementation of the PAGs. The results from this study revealed that direct referral to physical activity from a physician is twice as effective as simply providing information about physical activity with respect to adhering to the PAG recommendations in people with MS (65.2 % vs. 32.8 % for direct referral and control groups, respectively). Further, the results revealed that a high self-efficacy for exercise at baseline may be an additional predictor to PAG adherence. The purpose of the second study of this dissertation was to validate the PAGs for people with MS within a community-based intervention, and to affirm that following the PAGs for 16 weeks would result in improvements in fitness, mobility, fatigue symptoms and quality of life. The results from the second study confirm the effectiveness of the PAGs for people with MS for improving health, as significant improvements were observed in VO2 peak (+32 %), strength (+8-20 %), mobility (+14 %), fatigue symptoms (-40 %) and quality of life (+10-24 %). The purpose of the third and final study was to determine the effect of exercise on brain function and cognition in a sample of adults living with MS. Following the PAGs for 16 weeks led to significant improvements in processing speed and memory in adults living with MS. Overall, the results from this dissertation are extremely promising and highlight the importance of physical activity with respect to improving aspects of health and the effect it can have on MS-related symptoms and cognition in the MS population. Novel findings in this dissertation present convincing evidence that physicians should refer patients with MS to participate in exercise to improve MS-related symptoms and overall well-being.

Thesis

Doctor of Philosophy (PhD)

Advisors/Committee Members: Hicks, Audrey L., Kinesiology.

Subjects/Keywords: Multiple Sclerosis; Exercise

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APA (6^th Edition):

Canning, K. L. (2017). Physical Activity and Multiple Sclerosis. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/22039

Chicago Manual of Style (16^th Edition):

Canning, Karissa L. “Physical Activity and Multiple Sclerosis.” 2017. Doctoral Dissertation, McMaster University. Accessed February 22, 2020. http://hdl.handle.net/11375/22039.

MLA Handbook (7^th Edition):

Canning, Karissa L. “Physical Activity and Multiple Sclerosis.” 2017. Web. 22 Feb 2020.

Vancouver:

Canning KL. Physical Activity and Multiple Sclerosis. [Internet] [Doctoral dissertation]. McMaster University; 2017. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/11375/22039.

Council of Science Editors:

Canning KL. Physical Activity and Multiple Sclerosis. [Doctoral Dissertation]. McMaster University; 2017. Available from: http://hdl.handle.net/11375/22039

University of Debrecen

10. Ales, Maria Elena. Emerging Pharmacotherapy of Multiple Sclerosis .

Degree: DE – Általános Orvostudományi Kar, 2014, University of Debrecen

URL: http://hdl.handle.net/2437/194729

A detailed introduction of MS and a comprehensive presentation of the profiles of three of new drugs: DimethylFumarate (BG-12), Teriflunomide (Aubagio) and Campath-1H (Alemtuzumab). Advisors/Committee Members: Pórszász, Róbert (advisor), Debreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet (advisor).

Subjects/Keywords: Multiple sclerosis; pharmacotherapy

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APA (6^th Edition):

Ales, M. E. (2014). Emerging Pharmacotherapy of Multiple Sclerosis . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/194729

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ales, Maria Elena. “Emerging Pharmacotherapy of Multiple Sclerosis .” 2014. Thesis, University of Debrecen. Accessed February 22, 2020. http://hdl.handle.net/2437/194729.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ales, Maria Elena. “Emerging Pharmacotherapy of Multiple Sclerosis .” 2014. Web. 22 Feb 2020.

Vancouver:

Ales ME. Emerging Pharmacotherapy of Multiple Sclerosis . [Internet] [Thesis]. University of Debrecen; 2014. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/2437/194729.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ales ME. Emerging Pharmacotherapy of Multiple Sclerosis . [Thesis]. University of Debrecen; 2014. Available from: http://hdl.handle.net/2437/194729

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

11. Wieczorek, Deborah. New oral immunomodulatory agents in the treatment of Relapsing-Remitting Multiple Sclerosis .

Degree: DE – Általános Orvostudományi Kar, 2014, University of Debrecen

URL: http://hdl.handle.net/2437/194721

► The thesis talks about the newest oral immunomodulatory agents in the treatment of Multiple Sclerosis since its introduction in the year 2010 with focus on… (more)

Subjects/Keywords: Multiple Sclerosis; Treatment

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APA (6^th Edition):

Wieczorek, D. (2014). New oral immunomodulatory agents in the treatment of Relapsing-Remitting Multiple Sclerosis . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/194721

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wieczorek, Deborah. “New oral immunomodulatory agents in the treatment of Relapsing-Remitting Multiple Sclerosis .” 2014. Thesis, University of Debrecen. Accessed February 22, 2020. http://hdl.handle.net/2437/194721.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wieczorek, Deborah. “New oral immunomodulatory agents in the treatment of Relapsing-Remitting Multiple Sclerosis .” 2014. Web. 22 Feb 2020.

Vancouver:

Wieczorek D. New oral immunomodulatory agents in the treatment of Relapsing-Remitting Multiple Sclerosis . [Internet] [Thesis]. University of Debrecen; 2014. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/2437/194721.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wieczorek D. New oral immunomodulatory agents in the treatment of Relapsing-Remitting Multiple Sclerosis . [Thesis]. University of Debrecen; 2014. Available from: http://hdl.handle.net/2437/194721

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Limerick

12. Hughes, Lonan. The effects of adding a neuromuscular electrical stimulation device to a progressive resistance training programme in people with multiple sclerosis.

Degree: 2011, University of Limerick

URL: http://hdl.handle.net/10344/1676

► Background: Multiple Scelrosis (MS) is a progressive demyelinating disease of the central nervous system. It is recognised that people with MS (PwMS) who require a… (more)

▼ Background: Multiple Scelrosis (MS) is a progressive demyelinating disease of the central nervous system. It is recognised that people with MS (PwMS) who require a mobility aid, experience higher levels of disability, compared to those without mobility impairment. Decreased strength of the lower limbs is a primary problem, which is clinically associated with functional limitations in MS. Progressive resistance training (PRT) and neuromuscular electrical stimulation (NMES), to a lesser degree, are effective rehabilitation strategies to improve strength and function in PwMS. Presently, there is limited literature to support superimposing NMES on PRT in PwMS, particularly in the home-setting. The clinical profile literature of PwMS who use a walking aid, is also limited. Aims: The primary aim of this thesis was to investigate the effects of adding an NMES device (Kneehab) to a home-based PRT in PwMS who use a walking aid. Secondary aims included, evaluating the clinical profile of this population and determining participant satisfaction with the Kneehab device. Methods: The study used a randomised design to compare 12 weeks of homebased PRT to the same with superimposed NMES. The Kneehab device is designed for the quadriceps. The study assessor was blinded to group allocation. Participants were evaluated at week 0, 6 and 12 for a number of important clinical problems that were identified in the literature review. These included quadriceps strength (primary outcome), quadriceps thickness and endurance, spasticity, balance, mobility, health-related quality of life (HRQoL) and fatigue. Participants in the Kneehab group completed a device satisfaction questionnaire. Results: Thirty-seven PwMS participated in the study. The baseline data for this group showed that muscle weakness, balance and mobility limitations were severe problems. Moderate correlations between quadriceps endurance and balance (r=0.692), and quadriceps endurance and mobility (r=-0.583) were shown. Twenty-five participants completed the study (PRT n=10; Kneehab n=15). Two-drop-outs in the Kneehab group were due to muscle spasm induced by the device. In both groups, quadriceps strength increased non-significantly while balance and gluteal strength improved significantly (p<0.05). The Kneehab group improved significantly on plantar-flexion strength, rectus femoris thickness, quadriceps endurance, perceived spasticity, HRQoL ad fatigue (all p<0.05). The plantar-flexion strength, spasticity, HRQoL and fatigue improvements in the Kneehab group were significantly greater than the PRT group (all p<0.05). The Kneehab group also completed significantly more sessions, and total and quadriceps work (all p<0.05). Participants were satisfied with the usability and value of having the Kneehab device. Conclusion: This preliminary research indicates that adding an NMES device to a PRT programme for PwMS who use a walking aid results in better outcomes than PRT alone. This may be due to a placebo type effect, whereby participants were motivated to complete a more exercise… Advisors/Committee Members: Coote, Susan, Donnelly, Alan Edward, IRCSET.

Subjects/Keywords: multiple sclerosis; mobility

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hughes, L. (2011). The effects of adding a neuromuscular electrical stimulation device to a progressive resistance training programme in people with multiple sclerosis. (Thesis). University of Limerick. Retrieved from http://hdl.handle.net/10344/1676

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hughes, Lonan. “The effects of adding a neuromuscular electrical stimulation device to a progressive resistance training programme in people with multiple sclerosis.” 2011. Thesis, University of Limerick. Accessed February 22, 2020. http://hdl.handle.net/10344/1676.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hughes, Lonan. “The effects of adding a neuromuscular electrical stimulation device to a progressive resistance training programme in people with multiple sclerosis.” 2011. Web. 22 Feb 2020.

Vancouver:

Hughes L. The effects of adding a neuromuscular electrical stimulation device to a progressive resistance training programme in people with multiple sclerosis. [Internet] [Thesis]. University of Limerick; 2011. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10344/1676.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hughes L. The effects of adding a neuromuscular electrical stimulation device to a progressive resistance training programme in people with multiple sclerosis. [Thesis]. University of Limerick; 2011. Available from: http://hdl.handle.net/10344/1676

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Limerick

13. Garrett, Maria. Physiotherapy and exercise interventions for people with multiple sclerosis with minimal gait impairment.

Degree: 2011, University of Limerick

URL: http://hdl.handle.net/10344/1664

► Multiple Sclerosis (MS) is a demyelinating, degenerative disease of themcentral nervous system. It is the leading cause of disability in young adults for which there… (more)

▼ Multiple Sclerosis (MS) is a demyelinating, degenerative disease of themcentral nervous system. It is the leading cause of disability in young adults for which there is no cure. In a disease that has no cure, minimising its impact is arguably the main goal of intervention. The literature review demonstrated that exercise results in many important outcomes for People with MS (PwMS) with minimal gait impairment. However no community-based interventions have been evaluated. A large (N = 372), multi-centred, block-randomised, waiting list controlled trial was conducted with the primary objective of establishing the efficacy of three community-based exercise interventions. These were Physiotherapy (PT)-led exercise, Yoga and Fitness Instructor (FI)-led exercise delivered over an hour a week for ten weeks. The second objective was to establish if there was a difference between interventions. The third objective was to investigate the results at 3-month follow-up. The final objective was to establish predictors of outcome after the intervention period. Outcomes used were the Multiple Sclerosis Impact Scale-29, v 2 (MSIS-29, v2), the Modified Fatigue Impact Scale (MFIS) and the Six Minute Walk Test (6MWT). This study found that there was a significant improvement in the MSIS-29, v2 and the MFIS due to all interventions (p<0.05) and no change in the control. There was a significant improvement in the 6MWT due to PT-led and FI-led exercise interventions. There was no change in 6MWT in the Yoga group (p>0.05) and a trend towards worsening in the control. There were significant differences between the PT-led group and yoga (p<0.05) and FI-led exercise and yoga (p<0.05). At 3 month follow-up there was a statistically significant worsening of all of the positive findings. However outcomes remained significantly improved from baseline for the MSIS-29, v 2 (psychological component) and for the MFIS (p<0.05). Fifty-seven per cent of the variance in outcome was accounted for through five predictor variables. This study demonstrated important outcomes for PwMS. These findings suggest that some of the needs for PwMS with minimal gait impairment can be met in community settings which may ease the burden of health service delivery. This challenges the current model of one to one pysiotherapy in a medical setting. Future research should attend to developing interventions to increase long term exercise participation and explore other variables that may influence outcome. Advisors/Committee Members: Coote, Susan, Jakeman, Philip M..

Subjects/Keywords: multiple sclerosis; exercise

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Garrett, M. (2011). Physiotherapy and exercise interventions for people with multiple sclerosis with minimal gait impairment. (Thesis). University of Limerick. Retrieved from http://hdl.handle.net/10344/1664

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Garrett, Maria. “Physiotherapy and exercise interventions for people with multiple sclerosis with minimal gait impairment.” 2011. Thesis, University of Limerick. Accessed February 22, 2020. http://hdl.handle.net/10344/1664.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Garrett, Maria. “Physiotherapy and exercise interventions for people with multiple sclerosis with minimal gait impairment.” 2011. Web. 22 Feb 2020.

Vancouver:

Garrett M. Physiotherapy and exercise interventions for people with multiple sclerosis with minimal gait impairment. [Internet] [Thesis]. University of Limerick; 2011. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10344/1664.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Garrett M. Physiotherapy and exercise interventions for people with multiple sclerosis with minimal gait impairment. [Thesis]. University of Limerick; 2011. Available from: http://hdl.handle.net/10344/1664

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. Al-Sakran, Lina H 1982-. The Epidemiology and Pharmacoepidemiology of Multiple Sclerosis in Saskatchewan.

Degree: 2020, University of Saskatchewan

URL: http://hdl.handle.net/10388/12550

► My PhD project involved examining the epidemiology and pharmacoepidemiology of multiple sclerosis (MS) in Saskatchewan through the use of health administrative data. First, I validated… (more)

▼ My PhD project involved examining the epidemiology and pharmacoepidemiology of multiple sclerosis (MS) in Saskatchewan through the use of health administrative data. First, I validated a case definition of MS for administrative data, and then used the validated definition to determine the incidence and prevalence of MS in Saskatchewan. Prior to my studies, Saskatchewan was thought to have one of the highest rates of MS in Canada, but province-wide estimates were not available. I utilized the provincial MS cohort to then describe trends of healthcare utilization and the potential associations with comorbidities and use of disease-modifying therapies (DMTs) for MS using various study designs and methodologies. Both all-cause and MS-specific hospitalizations have decreased over time, but still remain higher than the general population. DMTs were associated with a minimal reduction in all-cause and MS-specific hospitalizations, and did not impact the number of physician services used. Higher rates of all-cause hospitalizations were observed in individuals that are older, have a higher comorbidity burden, and have previous hospitalizations, whereas the rate of MS-related hospitalizations increased with male sex and younger age. Comorbidity burden increased the rate of all-cause hospitalizations in a dose-response manner, but did not impact MS-related admissions. Finally, decreases in both all-cause and MS-specific hospitalizations was observed with an increase in disease duration. My research confirms that Saskatchewan has one of the highest rates of MS worldwide. While the introduction of DMTs has dramatically changed the management of MS, future research is needed to evaluate their true impact on subsequent healthcare utilization. Specific predictors, including individual comorbidities can be useful for identifying individuals with MS who are at higher risk for hospitalization, and can help guide collaborative efforts to manage the disease and prevent future hospitalizations. Advisors/Committee Members: Evans, Charity, Blackburn, Dave, Marrie, Ruth Ann, Knox, Katherine, Badea, Ildiko.

Subjects/Keywords: Multiple sclerosis; epidemiology

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APA (6^th Edition):

Al-Sakran, L. H. 1. (2020). The Epidemiology and Pharmacoepidemiology of Multiple Sclerosis in Saskatchewan. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/12550

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Al-Sakran, Lina H 1982-. “The Epidemiology and Pharmacoepidemiology of Multiple Sclerosis in Saskatchewan.” 2020. Thesis, University of Saskatchewan. Accessed February 22, 2020. http://hdl.handle.net/10388/12550.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Al-Sakran, Lina H 1982-. “The Epidemiology and Pharmacoepidemiology of Multiple Sclerosis in Saskatchewan.” 2020. Web. 22 Feb 2020.

Vancouver:

Al-Sakran LH1. The Epidemiology and Pharmacoepidemiology of Multiple Sclerosis in Saskatchewan. [Internet] [Thesis]. University of Saskatchewan; 2020. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10388/12550.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Al-Sakran LH1. The Epidemiology and Pharmacoepidemiology of Multiple Sclerosis in Saskatchewan. [Thesis]. University of Saskatchewan; 2020. Available from: http://hdl.handle.net/10388/12550

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Karagiannis, Fotios. Ταυτοποίηση μεταγραφικών παραγόντων που ρυθμίζουν την έκφραση κυτταροκινών σε αναπτυσσόμενα Τ κύτταρα.

Degree: 2016, University of Patras; Πανεπιστήμιο Πατρών

URL: http://hdl.handle.net/10442/hedi/41759

►

The activation and differentiation of naive T helper (Th) cells into distinct functional subpopulations is crucial for the effective defence and immune-regulation of the organism.… (more)

▼

The activation and differentiation of naive T helper (Th) cells into distinct functional subpopulations is crucial for the effective defence and immune-regulation of the organism. These subpopulations are considered different cell lineages and are defined by the expression of specific cytokines and transcription factors. When naïve Th cells are activated, through their TCR receptor, they are differentiated into dividing pre-Th0 proliferating precursors, before their differentiation to one of the Th effector subpopulations. The first cytokine that is produced during this process is IL-2, which is responsible for the proliferation and clonal expansion of T lymphocytes.The purpose of this thesis is to study the regulation of IL-2 expression in naive Th cells, through the binding of transcription factors onto the promoter of the IL-2 gene. In particular, we will examine the role of the transcription factor Ets-2 in the regulation of IL-2 expression in naive Th cells, in contrast with the well-studied transcription factors NFAT and Foxp3, which have the same binding site on the promoter of the IL- 2 gene, and also the correlation of Ets-2 with the pathogenesis of the autoimmune disease, Multiple Sclerosis.We have shown a different expression pattern of Ets-2 between Th cells with different levels of activation and human lymphoid organs and with the factors NFAT and Foxp3. In naïve Th cells of healthy donors, mRNA and protein expression levels and binding ability to the ARRE-2 element of the IL-2 gene promoter, are reduced after the activation of the cells, followed by an increase in the IL-2 expression. The binding ability of Ets-2 to the ARRE-2 element of the IL-2 gene promoter is stronger in naïve Th cells compared to activated naïve and memory Th cells.On the other hand, in cells obtained from patients with Multiple Sclerosis, the expression levels of Ets-2 were low both in naïve and memory Th cells. In contrast, these cells show an increased expression of IL-2 compared to those from healthy donors. It was also shown that Ets-2 doesn’t bind onto the ARRE-2 element of the IL- 2 gene promoter in patients’ cells. This silencing activity disappears in activated or memory Th cells. At the same time expression of Foxp3 is reduced in T regulatory cells of patients compared to those of healthy donors.Therefore we suggest that Ets-2 expression and protein binding to the ARRE-2 element of the IL-2 promoter are part of a strictly regulated process that results in a physiological transition of naive Th cells to Th0 cells upon antigenic stimulation. Low- level synthesis and dysfunction of Ets-2 and FoxP3 in Th cells of MS patients are probably responsible for the increase in pathological Th cell clones.

Η ενεργοποίηση και διαφοροποίηση των παρθενικών Τ βοηθητικών (Th) λεμφοκυττάρων σε διακριτούς λειτουργικούς υποπληθυσμούς είναι κρίσιμη για τη σωστή άμυνα και ανοσορύθμιση του οργανισμού. Οι υποπληθυσμοί αυτοί θεωρούνται ως διαφορετικές γενιές κυττάρων και καθορίζονται από την έκφραση συγκεκριμένων…

Subjects/Keywords: Σκλήρυνση κατά πλάκας; Multiple sclerosis

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APA (6^th Edition):

Karagiannis, F. (2016). Ταυτοποίηση μεταγραφικών παραγόντων που ρυθμίζουν την έκφραση κυτταροκινών σε αναπτυσσόμενα Τ κύτταρα. (Thesis). University of Patras; Πανεπιστήμιο Πατρών. Retrieved from http://hdl.handle.net/10442/hedi/41759

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Karagiannis, Fotios. “Ταυτοποίηση μεταγραφικών παραγόντων που ρυθμίζουν την έκφραση κυτταροκινών σε αναπτυσσόμενα Τ κύτταρα.” 2016. Thesis, University of Patras; Πανεπιστήμιο Πατρών. Accessed February 22, 2020. http://hdl.handle.net/10442/hedi/41759.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Karagiannis, Fotios. “Ταυτοποίηση μεταγραφικών παραγόντων που ρυθμίζουν την έκφραση κυτταροκινών σε αναπτυσσόμενα Τ κύτταρα.” 2016. Web. 22 Feb 2020.

Vancouver:

Karagiannis F. Ταυτοποίηση μεταγραφικών παραγόντων που ρυθμίζουν την έκφραση κυτταροκινών σε αναπτυσσόμενα Τ κύτταρα. [Internet] [Thesis]. University of Patras; Πανεπιστήμιο Πατρών; 2016. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10442/hedi/41759.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Karagiannis F. Ταυτοποίηση μεταγραφικών παραγόντων που ρυθμίζουν την έκφραση κυτταροκινών σε αναπτυσσόμενα Τ κύτταρα. [Thesis]. University of Patras; Πανεπιστήμιο Πατρών; 2016. Available from: http://hdl.handle.net/10442/hedi/41759

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Dalhousie University

16. Webber, Kristine. Health Promotion Experiences and Ideas for Health Promotion Improvements: An Interpretative Phenomenological Study of Nova Scotian Women with Multiple Sclerosis Through a Feminist, Disability Rights Lens.

Degree: MA, School of Health & Human Performance, 2014, Dalhousie University

URL: http://hdl.handle.net/10222/54050

► Most research in health promotion uses quantitative methodology to better understand the health promotion experiences of people with disabilities. This qualitative thesis study used Interpretative… (more)

Subjects/Keywords: Multiple Sclerosis; Health Promotion

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APA (6^th Edition):

Webber, K. (2014). Health Promotion Experiences and Ideas for Health Promotion Improvements: An Interpretative Phenomenological Study of Nova Scotian Women with Multiple Sclerosis Through a Feminist, Disability Rights Lens. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/54050

Chicago Manual of Style (16^th Edition):

Webber, Kristine. “Health Promotion Experiences and Ideas for Health Promotion Improvements: An Interpretative Phenomenological Study of Nova Scotian Women with Multiple Sclerosis Through a Feminist, Disability Rights Lens.” 2014. Masters Thesis, Dalhousie University. Accessed February 22, 2020. http://hdl.handle.net/10222/54050.

MLA Handbook (7^th Edition):

Webber, Kristine. “Health Promotion Experiences and Ideas for Health Promotion Improvements: An Interpretative Phenomenological Study of Nova Scotian Women with Multiple Sclerosis Through a Feminist, Disability Rights Lens.” 2014. Web. 22 Feb 2020.

Vancouver:

Webber K. Health Promotion Experiences and Ideas for Health Promotion Improvements: An Interpretative Phenomenological Study of Nova Scotian Women with Multiple Sclerosis Through a Feminist, Disability Rights Lens. [Internet] [Masters thesis]. Dalhousie University; 2014. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10222/54050.

Council of Science Editors:

Webber K. Health Promotion Experiences and Ideas for Health Promotion Improvements: An Interpretative Phenomenological Study of Nova Scotian Women with Multiple Sclerosis Through a Feminist, Disability Rights Lens. [Masters Thesis]. Dalhousie University; 2014. Available from: http://hdl.handle.net/10222/54050

University of Tasmania

17. Savage, Kathryn T. The evaluation of a therapeutic group for multiple sclerosis sufferers.

Degree: 1995, University of Tasmania

URL: https://eprints.utas.edu.au/21507/1/whole_SavageKathrynT1995_thesis.pdf

Subjects/Keywords: Multiple sclerosis

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APA (6^th Edition):

Savage, K. T. (1995). The evaluation of a therapeutic group for multiple sclerosis sufferers. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/21507/1/whole_SavageKathrynT1995_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Savage, Kathryn T. “The evaluation of a therapeutic group for multiple sclerosis sufferers.” 1995. Thesis, University of Tasmania. Accessed February 22, 2020. https://eprints.utas.edu.au/21507/1/whole_SavageKathrynT1995_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Savage, Kathryn T. “The evaluation of a therapeutic group for multiple sclerosis sufferers.” 1995. Web. 22 Feb 2020.

Vancouver:

Savage KT. The evaluation of a therapeutic group for multiple sclerosis sufferers. [Internet] [Thesis]. University of Tasmania; 1995. [cited 2020 Feb 22]. Available from: https://eprints.utas.edu.au/21507/1/whole_SavageKathrynT1995_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Savage KT. The evaluation of a therapeutic group for multiple sclerosis sufferers. [Thesis]. University of Tasmania; 1995. Available from: https://eprints.utas.edu.au/21507/1/whole_SavageKathrynT1995_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Aberdeen

18. Parikh, Khyati. Investigating the role of auto-immune responses to transient axonal glycoprotein-1 (TAG-1) in experimental autoimmune encephalomyelitis (EAE).

Degree: 2009, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=25214 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499706

► To examine the pathophysiological consequences of autoimmunity to TAG-1, CD4⁺ T cells and autoantibodies specific for TAG-1 were generated and their potential to induce EAE… (more)

Subjects/Keywords: 616.8; Multiple sclerosis : Autoimmunity

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APA (6^th Edition):

Parikh, K. (2009). Investigating the role of auto-immune responses to transient axonal glycoprotein-1 (TAG-1) in experimental autoimmune encephalomyelitis (EAE). (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=25214 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499706

Chicago Manual of Style (16^th Edition):

Parikh, Khyati. “Investigating the role of auto-immune responses to transient axonal glycoprotein-1 (TAG-1) in experimental autoimmune encephalomyelitis (EAE).” 2009. Doctoral Dissertation, University of Aberdeen. Accessed February 22, 2020. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=25214 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499706.

MLA Handbook (7^th Edition):

Parikh, Khyati. “Investigating the role of auto-immune responses to transient axonal glycoprotein-1 (TAG-1) in experimental autoimmune encephalomyelitis (EAE).” 2009. Web. 22 Feb 2020.

Vancouver:

Parikh K. Investigating the role of auto-immune responses to transient axonal glycoprotein-1 (TAG-1) in experimental autoimmune encephalomyelitis (EAE). [Internet] [Doctoral dissertation]. University of Aberdeen; 2009. [cited 2020 Feb 22]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=25214 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499706.

Council of Science Editors:

Parikh K. Investigating the role of auto-immune responses to transient axonal glycoprotein-1 (TAG-1) in experimental autoimmune encephalomyelitis (EAE). [Doctoral Dissertation]. University of Aberdeen; 2009. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=25214 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499706

University of Illinois – Urbana-Champaign

19. Socie, Michael. Gait variability in persons with multiple sclerosis.

Degree: MS, 0133, 2012, University of Illinois – Urbana-Champaign

URL: http://hdl.handle.net/2142/31135

► This thesis contains three investigations examining gait variability in people with multiple sclerosis (MS), which is a neurological disease that can result in significant walking… (more)

Subjects/Keywords: Gait; Multiple Sclerosis; Variability

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APA (6^th Edition):

Socie, M. (2012). Gait variability in persons with multiple sclerosis. (Thesis). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/31135

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Socie, Michael. “Gait variability in persons with multiple sclerosis.” 2012. Thesis, University of Illinois – Urbana-Champaign. Accessed February 22, 2020. http://hdl.handle.net/2142/31135.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Socie, Michael. “Gait variability in persons with multiple sclerosis.” 2012. Web. 22 Feb 2020.

Vancouver:

Socie M. Gait variability in persons with multiple sclerosis. [Internet] [Thesis]. University of Illinois – Urbana-Champaign; 2012. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/2142/31135.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Socie M. Gait variability in persons with multiple sclerosis. [Thesis]. University of Illinois – Urbana-Champaign; 2012. Available from: http://hdl.handle.net/2142/31135

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Johannesburg

20. Knipe, Irene Mary. An exploratory study to establish the effect of a homoeopathic complex remedy in the treatment of multiple sclerosis.

Degree: 2009, University of Johannesburg

URL: http://hdl.handle.net/10210/2590

M.Tech.

Subjects/Keywords: Multiple sclerosis

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APA (6^th Edition):

Knipe, I. M. (2009). An exploratory study to establish the effect of a homoeopathic complex remedy in the treatment of multiple sclerosis. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/2590

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Knipe, Irene Mary. “An exploratory study to establish the effect of a homoeopathic complex remedy in the treatment of multiple sclerosis.” 2009. Thesis, University of Johannesburg. Accessed February 22, 2020. http://hdl.handle.net/10210/2590.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Knipe, Irene Mary. “An exploratory study to establish the effect of a homoeopathic complex remedy in the treatment of multiple sclerosis.” 2009. Web. 22 Feb 2020.

Vancouver:

Knipe IM. An exploratory study to establish the effect of a homoeopathic complex remedy in the treatment of multiple sclerosis. [Internet] [Thesis]. University of Johannesburg; 2009. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10210/2590.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Knipe IM. An exploratory study to establish the effect of a homoeopathic complex remedy in the treatment of multiple sclerosis. [Thesis]. University of Johannesburg; 2009. Available from: http://hdl.handle.net/10210/2590

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. Saenz, Amaya. Mémoire et sclérose en plaques : Memory and multiple sclerosis.

Degree: Docteur es, Neuropsychologie, 2014, Lille 3

URL: http://www.theses.fr/2014LIL30055

►

Cette thèse propose d'explorer les capacités en mémoire épisodique de patients atteints de sclérose en plaques (sep). A notre connaissance, l'analyse des processus touchés et… (more)

▼

Cette thèse propose d'explorer les capacités en mémoire épisodique de patients atteints de sclérose en plaques (sep). A notre connaissance, l'analyse des processus touchés et préservés a fait l'objet de peu de travaux. L'une des raisons historiques semble être la création, dès les années 1980, de batteries d'évaluation rapide destinées aux neurologues. Ainsi, le golden standard de l'évaluation mnésique dans cette affection est le srt (dujardin et al., 2004) qui permet difficilement de contrôler les troubles d'encodage et de récupération. L'objectif de cette thèse sera dans un premier temps de documenter à l'aide d'épreuves permettant une analyse des processus mnésiques, les capacités de mémoire épisodique verbale dans la sep. Les performances de trois groupes de patients (sep, maladies d'Alzheimer et de Parkinson) seront comparées dans l'épreuve rl/ri-16 items. Cette étude sera destinée à vérifier si une majorité de patients sep présente une amélioration du rappel libre après délai contrairement aux deux autres affections testées. Si tel est le cas, l'hypothèse d'un temps de traitement, insuffisamment long pour les patients sep entre les rappels immédiats, mériterait d'être testée. Pour cela, une version parallèle du cvlt sera créée. Ainsi, les performances des patients seront comparées intra-individuellement lors de l'administration de l'épreuve dans sa version originale et lors d'une version où les temps entre les présentations de la liste de courses seront allongés. Un troisième volet sera destiné à tester les capacités de consolidation à long terme (une étude dans ce domaine pour la sep). Une analyse anatomo-fonctionnelle sera conduite en éprouvant l'hypothèse d'un lien entre les performances de rappel à une semaine et la volumétrie hippocampique des patients sep.

This thesis suggests exploring capacities in memory episodic of patients reached by multiple sclerosis. To our knowledge, the analysis of the affected and protected processes was the object of few works. One of the historic reasons seems to be the creation, from the 1980s, of batteries of fast evaluation intended for the neurologists. So, standard Golden of the mnesic evaluation in this affection is the srt (dujardin and al ., on 2004) which allows with difficulty to check) the disorders of encoding and recovery. The objective of this thesis will at first be to document by means of tests allowing an analysis of the mnesic processes, capacities of verbal episodic memory in frog. The performances of three groups of patients (frog, Alzheimer's diseases and of Parkinson) will be compared in the test rl / ri-16 items. This study will be intended to verify if a majority of patients frog presents an improvement of the free reminder after deadline contrary to two other tested affections. If that was the case, the hypothesis of a processing time, insufficiently long for the patients frog between the immediate reminders), would deserve to be tested. For that purpose, a parallel version of the cvlt will be created. So, the performances of the patients will be…

Advisors/Committee Members: Samson, Séverine (thesis director), Ehrlé, Nathalie (thesis director).

Subjects/Keywords: Sclérose en plaques; Multiple sclerosis

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APA (6^th Edition):

Saenz, A. (2014). Mémoire et sclérose en plaques : Memory and multiple sclerosis. (Doctoral Dissertation). Lille 3. Retrieved from http://www.theses.fr/2014LIL30055

Chicago Manual of Style (16^th Edition):

Saenz, Amaya. “Mémoire et sclérose en plaques : Memory and multiple sclerosis.” 2014. Doctoral Dissertation, Lille 3. Accessed February 22, 2020. http://www.theses.fr/2014LIL30055.

MLA Handbook (7^th Edition):

Saenz, Amaya. “Mémoire et sclérose en plaques : Memory and multiple sclerosis.” 2014. Web. 22 Feb 2020.

Vancouver:

Saenz A. Mémoire et sclérose en plaques : Memory and multiple sclerosis. [Internet] [Doctoral dissertation]. Lille 3; 2014. [cited 2020 Feb 22]. Available from: http://www.theses.fr/2014LIL30055.

Council of Science Editors:

Saenz A. Mémoire et sclérose en plaques : Memory and multiple sclerosis. [Doctoral Dissertation]. Lille 3; 2014. Available from: http://www.theses.fr/2014LIL30055

University of Southern California

22. Zhang, Naibo. Targeting Ryk-signaling to attenuate multiple sclerosis by promoting oligodendrocyte differentiation and myelination.

Degree: MS, Biochemistry and Molecular Biology, 2015, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/615832/rec/6322

► Multiple Sclerosis (MS) is a CNS degenerative disease. It is one of the most common chronic disabling CNS disease in young adults. In MS, oligodendrocytes(OLs)… (more)

Subjects/Keywords: multiple sclerosis; oligodendrocytes; remyelination

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APA (6^th Edition):

Zhang, N. (2015). Targeting Ryk-signaling to attenuate multiple sclerosis by promoting oligodendrocyte differentiation and myelination. (Masters Thesis). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/615832/rec/6322

Chicago Manual of Style (16^th Edition):

Zhang, Naibo. “Targeting Ryk-signaling to attenuate multiple sclerosis by promoting oligodendrocyte differentiation and myelination.” 2015. Masters Thesis, University of Southern California. Accessed February 22, 2020. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/615832/rec/6322.

MLA Handbook (7^th Edition):

Zhang, Naibo. “Targeting Ryk-signaling to attenuate multiple sclerosis by promoting oligodendrocyte differentiation and myelination.” 2015. Web. 22 Feb 2020.

Vancouver:

Zhang N. Targeting Ryk-signaling to attenuate multiple sclerosis by promoting oligodendrocyte differentiation and myelination. [Internet] [Masters thesis]. University of Southern California; 2015. [cited 2020 Feb 22]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/615832/rec/6322.

Council of Science Editors:

Zhang N. Targeting Ryk-signaling to attenuate multiple sclerosis by promoting oligodendrocyte differentiation and myelination. [Masters Thesis]. University of Southern California; 2015. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/615832/rec/6322

University of Sydney

23. Irving, Harry George. The presence of renal autoantibodies in multiple sclerosis .

Degree: 2016, University of Sydney

URL: http://hdl.handle.net/2123/16518

► Multiple sclerosis (MS) is a chronic neurological disorder characterised by demyelinating inflammatory lesions within the central nervous system, which are separated in both time and… (more)

▼ Multiple sclerosis (MS) is a chronic neurological disorder characterised by demyelinating inflammatory lesions within the central nervous system, which are separated in both time and space. Although the cause of MS is unknown it is generally agreed that the disease is a result of an autoimmune response against components of the central nervous system (CNS) that occurs through complex interactions between genetic and environmental factors. There is growing evidence that autoreactive antibodies may play a role in the progression of the disease analogous to the role that has been established for aquaporin-‐4 antibodies in the pathogenic process of the demyelinating disease, neuromyelitis optica (NMO). In the process of screening the sera of neurological patients for NMO antibodies, a preliminary study found that a novel renal antibody may be present in patients with MS. This renal antibody bound to elements in the proximal brush border and was referred to as ABBA (anti-‐brush border antibody). The current study aimed to: determine the prevalence of ABBA in MS, determine whether there is a correlation with ABBA and any brain antibodies and determine the target to which ABBA binds. Indirect immunofluorescence on rat renal and neural tissue was used to determine the prevalence of renal antibodies while human renal cell lines were used to determine the antigenic target to which these antibodies bind. This study is the first to investigate the presence of ABBA and other renal antibodies in MS patients and the first to identify high titre antibodies in the disease. While the presence of ABBA was not found to be significantly different between MS cases and control groups, ABBA was found to be more prevalent in inflammatory neurological conditions and a correlation was found between ABBA and axonal-‐nodal antibodies in inflammatory conditions. The current study was unable to identify the target to which ABBA binds. The presence of high titre antiglomerular antibodies (AGLA), anti-‐distal tubule (ADA) and anti-‐cortical collecting duct antibodies (ACCA) in the serum of patients with MS was an unexpected and novel finding and has not previously been documented. Neuroinflammatory cases had a higher prevalence of AGLA, which were also associated with the presence of both anti-‐axonal nodal antibodies and anti-‐ perivascular antibodies. In the absence of renal pathology or documented nephrotoxic medications as well as not identifying the antigenic target, the significance of this observation remains unclear. However, possible explanations are discussed.

Subjects/Keywords: Multiple Sclerosis; autoantibodies; renal antibodies

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APA (6^th Edition):

Irving, H. G. (2016). The presence of renal autoantibodies in multiple sclerosis . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/16518

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Irving, Harry George. “The presence of renal autoantibodies in multiple sclerosis .” 2016. Thesis, University of Sydney. Accessed February 22, 2020. http://hdl.handle.net/2123/16518.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Irving, Harry George. “The presence of renal autoantibodies in multiple sclerosis .” 2016. Web. 22 Feb 2020.

Vancouver:

Irving HG. The presence of renal autoantibodies in multiple sclerosis . [Internet] [Thesis]. University of Sydney; 2016. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/2123/16518.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Irving HG. The presence of renal autoantibodies in multiple sclerosis . [Thesis]. University of Sydney; 2016. Available from: http://hdl.handle.net/2123/16518

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Victoria

24. Wishart, Heather Ann. Interhemispheric transfer in multiple sclerosis.

Degree: Department of Psychology, 2018, University of Victoria

URL: https://dspace.library.uvic.ca//handle/1828/9686

► Given previous indications of callosal damage and dysfunction in multiple sclerosis (MS; e.g., Huber et al.,1987; Jacobson, Deppe & Murray, 1983), it was hypothesized that… (more)

Subjects/Keywords: Multiple sclerosis; Psychological aspects

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APA (6^th Edition):

Wishart, H. A. (2018). Interhemispheric transfer in multiple sclerosis. (Thesis). University of Victoria. Retrieved from https://dspace.library.uvic.ca//handle/1828/9686

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wishart, Heather Ann. “Interhemispheric transfer in multiple sclerosis.” 2018. Thesis, University of Victoria. Accessed February 22, 2020. https://dspace.library.uvic.ca//handle/1828/9686.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wishart, Heather Ann. “Interhemispheric transfer in multiple sclerosis.” 2018. Web. 22 Feb 2020.

Vancouver:

Wishart HA. Interhemispheric transfer in multiple sclerosis. [Internet] [Thesis]. University of Victoria; 2018. [cited 2020 Feb 22]. Available from: https://dspace.library.uvic.ca//handle/1828/9686.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wishart HA. Interhemispheric transfer in multiple sclerosis. [Thesis]. University of Victoria; 2018. Available from: https://dspace.library.uvic.ca//handle/1828/9686

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cambridge

25. Peruzzotti-Jametti, Luca. Neural stem cells respond to extracellular succinate via SUCNR1/GPR91 to ameliorate chronic neuroinflammation.

Degree: PhD, 2018, University of Cambridge

URL: https://www.repository.cam.ac.uk/handle/1810/277000 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744927

► Neural stem cell (NSC) transplantation induces recovery in animal models of central nervous system (CNS) diseases, in part by modulating adaptive and innate immune responses.… (more)

Subjects/Keywords: Multiple sclerosis; Stem cells; Metabolism

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APA (6^th Edition):

Peruzzotti-Jametti, L. (2018). Neural stem cells respond to extracellular succinate via SUCNR1/GPR91 to ameliorate chronic neuroinflammation. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/277000 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744927

Chicago Manual of Style (16^th Edition):

Peruzzotti-Jametti, Luca. “Neural stem cells respond to extracellular succinate via SUCNR1/GPR91 to ameliorate chronic neuroinflammation.” 2018. Doctoral Dissertation, University of Cambridge. Accessed February 22, 2020. https://www.repository.cam.ac.uk/handle/1810/277000 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744927.

MLA Handbook (7^th Edition):

Peruzzotti-Jametti, Luca. “Neural stem cells respond to extracellular succinate via SUCNR1/GPR91 to ameliorate chronic neuroinflammation.” 2018. Web. 22 Feb 2020.

Vancouver:

Peruzzotti-Jametti L. Neural stem cells respond to extracellular succinate via SUCNR1/GPR91 to ameliorate chronic neuroinflammation. [Internet] [Doctoral dissertation]. University of Cambridge; 2018. [cited 2020 Feb 22]. Available from: https://www.repository.cam.ac.uk/handle/1810/277000 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744927.

Council of Science Editors:

Peruzzotti-Jametti L. Neural stem cells respond to extracellular succinate via SUCNR1/GPR91 to ameliorate chronic neuroinflammation. [Doctoral Dissertation]. University of Cambridge; 2018. Available from: https://www.repository.cam.ac.uk/handle/1810/277000 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744927

University of Oxford

26. Lam Haces Gil, Karla G. Investigation into the epigenetic mechanisms involved in microglial activation in the animal model of multiple sclerosis.

Degree: PhD, 2013, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:b4de0ef7-7588-4381-b099-9c8567805546 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.655019

► In patients with multiple sclerosis (MS), microglia become activated due to the autoimmune inflammatory response which is directed against the central nervous system (CNS). Following… (more)

▼ In patients with multiple sclerosis (MS), microglia become activated due to the autoimmune inflammatory response which is directed against the central nervous system (CNS). Following the first disease relapse, microglia remain activated and do not return to a resting state during remissions. Chronically-activated microglia release inflammatory mediators that cause CNS tissue damage, and as such, MS progression has been associated with widespread, chronic microglial activation that correlates with neurodegeneration. To date, only one histone demethylase, Jmjd3, has been described to have a role in inflammation. In agreement with this, up-regulation of Jmjd3 expression was observed following microglial treatment with several pro-inflammatory stimuli, including a range of toll-like receptors ligands and cytokines, suggesting a universal role of Jmjd3 during microglial activation. Subsequent ChIP-qPCR assays revealed that Jmjd3 was recruited to the promoters of Il6, Ccl3, Ccl5 and Nos2 following activation, which, in turn, presented a decrease in their H3K27me3 levels. Using an experimental autoimmune encephalomyelitis (EAE) mouse model of MS, Jmjd3 expression was shown to be increased in activated microglia from mice in the acute and late phases of disease. Immunization with complete Freud’s adjuvant (CFA) alone, also caused microglial activation with Jmjd3 induction, indicating a CFA-mediated TLR2 and TLR4 stimulation of microglia. Further investigation, in which primary microglia were isolated from mice deficient in Jmjd3 (Jmjd3-/-), however demonstrated that the absence of Jmjd3 alone had no resultant effect on the expression of a subset of immune response and inflammation related genes, including the Jmjd3 target genes Il6, Ccl3, Ccl5 and Nos2, before or after activation. This suggested that Jmjd3 acts in concert with a repertoire of other demethylases to facilitate microglia activation, and as such was rendered redundant in this setting. Deciphering the epigenetic profile of microglia in MS and determining whether it is involved in the maintenance of chronic microglial activation in the progressive phase of the disease remains an important line of investigation, and through a clearer understanding of its role in MS pathophysiology, could lead to the development of novel therapeutic interventions in the future.

Subjects/Keywords: 616.8; Multiple Sclerosis; Epigenetics; Microglia

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APA (6^th Edition):

Lam Haces Gil, K. G. (2013). Investigation into the epigenetic mechanisms involved in microglial activation in the animal model of multiple sclerosis. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:b4de0ef7-7588-4381-b099-9c8567805546 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.655019

Chicago Manual of Style (16^th Edition):

Lam Haces Gil, Karla G. “Investigation into the epigenetic mechanisms involved in microglial activation in the animal model of multiple sclerosis.” 2013. Doctoral Dissertation, University of Oxford. Accessed February 22, 2020. http://ora.ox.ac.uk/objects/uuid:b4de0ef7-7588-4381-b099-9c8567805546 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.655019.

MLA Handbook (7^th Edition):

Lam Haces Gil, Karla G. “Investigation into the epigenetic mechanisms involved in microglial activation in the animal model of multiple sclerosis.” 2013. Web. 22 Feb 2020.

Vancouver:

Lam Haces Gil KG. Investigation into the epigenetic mechanisms involved in microglial activation in the animal model of multiple sclerosis. [Internet] [Doctoral dissertation]. University of Oxford; 2013. [cited 2020 Feb 22]. Available from: http://ora.ox.ac.uk/objects/uuid:b4de0ef7-7588-4381-b099-9c8567805546 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.655019.

Council of Science Editors:

Lam Haces Gil KG. Investigation into the epigenetic mechanisms involved in microglial activation in the animal model of multiple sclerosis. [Doctoral Dissertation]. University of Oxford; 2013. Available from: http://ora.ox.ac.uk/objects/uuid:b4de0ef7-7588-4381-b099-9c8567805546 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.655019

University of Aberdeen

27. Visser, Elizabeth Magdalena.; University of Aberdeen.School of Life Sciences and Medicine.; Medical Research Council (Great Britain); Scotland.Chief Scientist Office. The prevalence of multiple sclerosis in the North of Scotland.

Degree: School of Life Sciences and Medicine., 2013, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=211437 ; http://digitool2.abdn.ac.uk:1801/webclient/DeliveryManager?pid=211437&custom_att_2=simple_viewer

Subjects/Keywords: Multiple sclerosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Visser, E. M. ;. U. o. A. S. o. L. S. a. M. ;. M. R. C. (. B. S. C. S. O. (2013). The prevalence of multiple sclerosis in the North of Scotland. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=211437 ; http://digitool2.abdn.ac.uk:1801/webclient/DeliveryManager?pid=211437&custom_att_2=simple_viewer

Chicago Manual of Style (16^th Edition):

Visser, Elizabeth Magdalena ; University of Aberdeen School of Life Sciences and Medicine ; Medical Research Council (Great Britain); Scotland Chief Scientist Office. “The prevalence of multiple sclerosis in the North of Scotland.” 2013. Doctoral Dissertation, University of Aberdeen. Accessed February 22, 2020. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=211437 ; http://digitool2.abdn.ac.uk:1801/webclient/DeliveryManager?pid=211437&custom_att_2=simple_viewer.

MLA Handbook (7^th Edition):

Visser, Elizabeth Magdalena ; University of Aberdeen School of Life Sciences and Medicine ; Medical Research Council (Great Britain); Scotland Chief Scientist Office. “The prevalence of multiple sclerosis in the North of Scotland.” 2013. Web. 22 Feb 2020.

Vancouver:

Visser EM;UoASoLSaM;MRC(BSCSO. The prevalence of multiple sclerosis in the North of Scotland. [Internet] [Doctoral dissertation]. University of Aberdeen; 2013. [cited 2020 Feb 22]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=211437 ; http://digitool2.abdn.ac.uk:1801/webclient/DeliveryManager?pid=211437&custom_att_2=simple_viewer.

Council of Science Editors:

Visser EM;UoASoLSaM;MRC(BSCSO. The prevalence of multiple sclerosis in the North of Scotland. [Doctoral Dissertation]. University of Aberdeen; 2013. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=211437 ; http://digitool2.abdn.ac.uk:1801/webclient/DeliveryManager?pid=211437&custom_att_2=simple_viewer

University of Otago

28. Boland, Pauline. Coping and Multiple Sclerosis:Individuals with Multiple Sclerosis and their Significant Others .

Degree: 2011, University of Otago

URL: http://hdl.handle.net/10523/1758

► Multiple Sclerosis (MS) is a degenerative condition which affects everyone differently as regards emergence of symptoms. The illness uncertainty associated with MS has ramifications for… (more)

▼ Multiple Sclerosis (MS) is a degenerative condition which affects everyone differently as regards emergence of symptoms. The illness uncertainty associated with MS has ramifications for how those with the condition and those close to them cope with the illness, with each other and with the effect it has on their lives. Health professionals acknowledge that those with MS need to be seen in the context of their families. The perspective of significant others (SOs) need to be acknowledged. However there is a lack of knowledge about what to expect about how people cope as a dyad. This study used Interpretative Phenomenological Analysis (IPA) to explore how those with MS and their SOs cope with this illness in their lives. Seven couples were recruited using purposive sampling through the MS society. Each person in the couple was interviewed separately using a semi-structured interview schedule. The interviews were transcribed and analysed using the principles of IPA to produce overarching themes and sub themes. Peer coding by two supervisors helped to enrich the analysis and contributed to the trustworthiness of the findings. Three overarching themes emerged from the data, two overarching themes with four sub themes and one overarching theme with 3 sub themes. These overarching themes are labelled: Resources and Barriers to Coping, Coping Together: "Peaks and Troughs" and Coping over the Long Haul. Two integrative themes emerged, which were called Faith in Self and Faith in Each Other, encapsulating the participants’ identified primary resources which enabled them to cope. The results of this study will assist health professionals to better comprehend how those with MS cope in an interconnected way with those with whom they share their lives. This research has highlighted the individual preferences about coping style and choice of coping strategies from the perspective of both the person with MS and their significant other. In addition, the nature of the relationship between couples, and the impact this relationship has on their ability to cope, needs to be understood and acknowledged by health professionals. The results of this study indicated that the relationship can be a powerful resource for couples during times of illness related stress. This study adds to the small but growing body of literature about how couples with MS make sense of the disease and how they develop coping strategies relevant to their relationship. Advisors/Committee Members: Levack, William (advisor).

Subjects/Keywords: Coping; Multiple Sclerosis; Dyad

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Boland, P. (2011). Coping and Multiple Sclerosis:Individuals with Multiple Sclerosis and their Significant Others . (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/1758

Chicago Manual of Style (16^th Edition):

Boland, Pauline. “Coping and Multiple Sclerosis:Individuals with Multiple Sclerosis and their Significant Others .” 2011. Masters Thesis, University of Otago. Accessed February 22, 2020. http://hdl.handle.net/10523/1758.

MLA Handbook (7^th Edition):

Boland, Pauline. “Coping and Multiple Sclerosis:Individuals with Multiple Sclerosis and their Significant Others .” 2011. Web. 22 Feb 2020.

Vancouver:

Boland P. Coping and Multiple Sclerosis:Individuals with Multiple Sclerosis and their Significant Others . [Internet] [Masters thesis]. University of Otago; 2011. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10523/1758.

Council of Science Editors:

Boland P. Coping and Multiple Sclerosis:Individuals with Multiple Sclerosis and their Significant Others . [Masters Thesis]. University of Otago; 2011. Available from: http://hdl.handle.net/10523/1758

University of Debrecen

29. Zohoor, Asiri. Multiple sclerosis : oral versus parenteral treatment .

Degree: DE – Általános Orvostudományi Kar, University of Debrecen

URL: http://hdl.handle.net/2437/218611

► This thesis was prepared following deepening interest in the existing therapies options available for MS, a disease which presently has no cure. I wrote this… (more)

Subjects/Keywords: multiple sclerosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zohoor, A. (n.d.). Multiple sclerosis : oral versus parenteral treatment . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/218611

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zohoor, Asiri. “Multiple sclerosis : oral versus parenteral treatment .” Thesis, University of Debrecen. Accessed February 22, 2020. http://hdl.handle.net/2437/218611.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zohoor, Asiri. “Multiple sclerosis : oral versus parenteral treatment .” Web. 22 Feb 2020.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Zohoor A. Multiple sclerosis : oral versus parenteral treatment . [Internet] [Thesis]. University of Debrecen; [cited 2020 Feb 22]. Available from: http://hdl.handle.net/2437/218611.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Zohoor A. Multiple sclerosis : oral versus parenteral treatment . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/218611

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

University of Debrecen

30. Salehi, Mohammad Reza. Pharmacological treatment of multiple sclerosis .

Degree: DE – Általános Orvostudományi Kar, 2014, University of Debrecen

URL: http://hdl.handle.net/2437/194933

► Because of autoimmunity nature of MS the main therapy is focused on immunosuppressant or immunomodulation. IFN-b and Glatimer acetate with minimal side effect profile and… (more)

Subjects/Keywords: Multiple Sclerosis; Pharmacological treatmnt

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Salehi, M. R. (2014). Pharmacological treatment of multiple sclerosis . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/194933

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Salehi, Mohammad Reza. “Pharmacological treatment of multiple sclerosis .” 2014. Thesis, University of Debrecen. Accessed February 22, 2020. http://hdl.handle.net/2437/194933.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Salehi, Mohammad Reza. “Pharmacological treatment of multiple sclerosis .” 2014. Web. 22 Feb 2020.

Vancouver:

Salehi MR. Pharmacological treatment of multiple sclerosis . [Internet] [Thesis]. University of Debrecen; 2014. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/2437/194933.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Salehi MR. Pharmacological treatment of multiple sclerosis . [Thesis]. University of Debrecen; 2014. Available from: http://hdl.handle.net/2437/194933

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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