You searched for subject:(Multiple sclerosis).
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Oregon State University
1.
Nery, Mara B.
Multiple Sclerosis and Wellness : How Self-Compassion Influences Physical Activity and Health-Related Quality of Life.
Degree: PhD, Kinesiology, 2016, Oregon State University
URL: http://hdl.handle.net/1957/59833 
► Multiple Sclerosis (MS) is an autoimmune condition that affects the central nervous system, and impacts the lives of over 400,000 individuals in the US. These…
(more)
▼ Multiple Sclerosis (MS) is an autoimmune condition that affects the central nervous system, and impacts the lives of over 400,000 individuals in the US. These individuals face unpredictable relapses of disabling conditions, are less active and experience poorer quality of life than the general population. Health professionals are challenged to find ways to increase engagement in health promoting behaviors that can improve function and overall wellness for this population. The major objective of this dissertation was to expand the literature on promoting health behaviors and wellness through self-compassion for individuals with MS. One theoretical model that has the potential to help researchers and program developers understand how to effectively improve engagement in health behaviors for individuals with MS is Reyes’ model of self-compassion. The first aim of the first study was to cross-validate Reyes conceptual model of self-compassion among individuals with MS. Although the model is promising, recent studies suggest fatigue may play a unique role for individuals with MS. The second aim of the first study was to examine the utility of an alternative model, which expands upon Reyes’ model. Furthermore, self-compassion has been shown to improve resilience and quality of life in the general population. The second study aimed to understand the relationship between self-compassion, resilience and health-related quality of life for individuals with MS. Individuals (N = 259) participated in a survey measuring their perceived fatigue, self-compassion, psychological needs related to exercise, resilience, health-related quality of life, and self-reported physical activity, as well as a demographic questionnaire. Participants were predominately white (90%) females (84%), with a relapse-remitting MS course (73%), and a mean age of 48.60 (SD = 10.46). Study 1 validated the use of Reyes’ conceptual model of self-compassion. However, the alternative model, which added direct paths to psychological needs and fatigue, showed improved fit over Reyes’ model for this population. Results demonstrated that fatigue predicted engagement in physical activity in both models, which was expected. However, in the alternative model, fatigue significantly negatively predicted psychological needs for engaging in exercise, but showed a non-significant, weak relationship with physical activity behavior, which was unexpected. Study 2 examined the relationship between self-compassion, resilience, and health-related quality of life for individuals with MS using mediation analysis. Results from this study showed that resilience was a partial mediator between self-compassion and health-related quality of life. The results from these studies can inform future health interventions seeking to improve health-related quality of life and engagement in physical activity in this population. Both of these studies contribute to the theoretical knowledge of self-compassion, wellness, and behavior change for individuals with MS.
Advisors/Committee Members: Yun, Joonkoo (advisor), Ebbeck, Vicki (committee member).
Subjects/Keywords: Multiple Sclerosis; Multiple sclerosis
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APA (6th Edition):
Nery, M. B. (2016). Multiple Sclerosis and Wellness : How Self-Compassion Influences Physical Activity and Health-Related Quality of Life. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/59833
Chicago Manual of Style (16th Edition):
Nery, Mara B. “Multiple Sclerosis and Wellness : How Self-Compassion Influences Physical Activity and Health-Related Quality of Life.” 2016. Doctoral Dissertation, Oregon State University. Accessed February 26, 2021.
http://hdl.handle.net/1957/59833.
MLA Handbook (7th Edition):
Nery, Mara B. “Multiple Sclerosis and Wellness : How Self-Compassion Influences Physical Activity and Health-Related Quality of Life.” 2016. Web. 26 Feb 2021.
Vancouver:
Nery MB. Multiple Sclerosis and Wellness : How Self-Compassion Influences Physical Activity and Health-Related Quality of Life. [Internet] [Doctoral dissertation]. Oregon State University; 2016. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/1957/59833.
Council of Science Editors:
Nery MB. Multiple Sclerosis and Wellness : How Self-Compassion Influences Physical Activity and Health-Related Quality of Life. [Doctoral Dissertation]. Oregon State University; 2016. Available from: http://hdl.handle.net/1957/59833
University of Utah
2.
Peterson, Lisa K.
Expanding the spectrum of autoimmunity induced with myelin oligodendrocyte glycoprotein.
Degree: PhD, Pathology;, 2007, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1130/rec/453
► Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. Experimental autoimmune encephalomyelitis (EAE) is an autoimmune model of MS, induced by…
(more)
▼ Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. Experimental autoimmune encephalomyelitis (EAE) is an autoimmune model of MS, induced by sensitization with myelin proteins of their encephalitogenic peptides. Sensitization with amino acids 92-106 of myelin oligodendrocyte glycoprotein (MOG) induces different disease courses and neuropathology in A.SW and SJL/J mice. SJL/J mice develop a relapsing-remitting (RR-EAE) disease course characterized by mild demyelinating disease with perivascular T cell infiltration. In contrast, A.SW mice develop a progressive (P-EAE) disease course characterized by large areas of plaque-like demyelination with Ig deposition, polymorphonuclear (PMN) cell infiltration and minimal T cell infiltration and high MOG antibody titers in the serum. This thesis describes, as part of the elucidation of the role of antibody in determining disease course and neuropathology, the generation and characterization of hybridomas producing antibody reactive with MOG92-106. Two MOG92-106 hybridomas produced polyreactive IgM antibodies encoded by immunoglobulin genes in their germline configuration, indicating that the antibodies are natural autoantibodies (NAA). These MOG92-106 reactive NNA bind myelin and cause demyelination in vivo, suggesting that they could contribute to the pathogenesis of P-EAE. In addition, sensitization of A.S.W. mice with MOG92-106 or intraperitoneal injection of the MOG92-106 reactive hybridomas resulted in antibody deposition in glomeruli of kidneys and proteinuria, demonstrating that MOG92-106 reacative NAA can induce systemic autoimmunity. However, depletion of B-1 cells, the main produces of NAA, had minimal effects on the development of demyelination, antibody deposition or disease progression in mice sensitized with MOG92-106. These results indicate that while MOG92-106 reacative NAA are capable of inducing pathology in the CNS and kidneys, they play a minor role in the pathogenesis of MOG92-106-infduced EAE. In addition, this thesis describes induction of another combination of disease course and neuropathology in B10.S mice. B10.S mice have previously been considered resistant to EAE, but sensitization with MOG92-106 resulted in neuropathology in 93% of the mice and monophasic or relapsing-remitting disease course in 30% of the mice. Taken together, this work expands the spectrum of autoimmune disease that can be induced and investigated using MOG92-106.
Subjects/Keywords: Multiple Sclerosis; Antibodies
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APA (6th Edition):
Peterson, L. K. (2007). Expanding the spectrum of autoimmunity induced with myelin oligodendrocyte glycoprotein. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1130/rec/453
Chicago Manual of Style (16th Edition):
Peterson, Lisa K. “Expanding the spectrum of autoimmunity induced with myelin oligodendrocyte glycoprotein.” 2007. Doctoral Dissertation, University of Utah. Accessed February 26, 2021.
http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1130/rec/453.
MLA Handbook (7th Edition):
Peterson, Lisa K. “Expanding the spectrum of autoimmunity induced with myelin oligodendrocyte glycoprotein.” 2007. Web. 26 Feb 2021.
Vancouver:
Peterson LK. Expanding the spectrum of autoimmunity induced with myelin oligodendrocyte glycoprotein. [Internet] [Doctoral dissertation]. University of Utah; 2007. [cited 2021 Feb 26].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1130/rec/453.
Council of Science Editors:
Peterson LK. Expanding the spectrum of autoimmunity induced with myelin oligodendrocyte glycoprotein. [Doctoral Dissertation]. University of Utah; 2007. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1130/rec/453
3.
Al-Sakran, Lina H 1982-.
The Epidemiology and Pharmacoepidemiology of Multiple Sclerosis in Saskatchewan.
Degree: 2020, University of Saskatchewan
URL: http://hdl.handle.net/10388/12550
► My PhD project involved examining the epidemiology and pharmacoepidemiology of multiple sclerosis (MS) in Saskatchewan through the use of health administrative data. First, I validated…
(more)
▼ My PhD project involved examining the epidemiology and pharmacoepidemiology of
multiple sclerosis (MS) in Saskatchewan through the use of health administrative data. First, I validated a case definition of MS for administrative data, and then used the validated definition to determine the incidence and prevalence of MS in Saskatchewan. Prior to my studies, Saskatchewan was thought to have one of the highest rates of MS in Canada, but province-wide estimates were not available.
I utilized the provincial MS cohort to then describe trends of healthcare utilization and the potential associations with comorbidities and use of disease-modifying therapies (DMTs) for MS using various study designs and methodologies. Both all-cause and MS-specific hospitalizations have decreased over time, but still remain higher than the general population.
DMTs were associated with a minimal reduction in all-cause and MS-specific hospitalizations, and did not impact the number of physician services used. Higher rates of all-cause hospitalizations were observed in individuals that are older, have a higher comorbidity burden, and have previous hospitalizations, whereas the rate of MS-related hospitalizations increased with male sex and younger age. Comorbidity burden increased the rate of all-cause hospitalizations in a dose-response manner, but did not impact MS-related admissions. Finally, decreases in both all-cause and MS-specific hospitalizations was observed with an increase in disease duration.
My research confirms that Saskatchewan has one of the highest rates of MS worldwide. While the introduction of DMTs has dramatically changed the management of MS, future research is needed to evaluate their true impact on subsequent healthcare utilization. Specific predictors, including individual comorbidities can be useful for identifying individuals with MS who are at higher risk for hospitalization, and can help guide collaborative efforts to manage the disease and prevent future hospitalizations.
Advisors/Committee Members: Evans, Charity, Blackburn, Dave, Marrie, Ruth Ann, Knox, Katherine, Badea, Ildiko.
Subjects/Keywords: Multiple sclerosis; epidemiology
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APA (6th Edition):
Al-Sakran, L. H. 1. (2020). The Epidemiology and Pharmacoepidemiology of Multiple Sclerosis in Saskatchewan. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/12550
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Al-Sakran, Lina H 1982-. “The Epidemiology and Pharmacoepidemiology of Multiple Sclerosis in Saskatchewan.” 2020. Thesis, University of Saskatchewan. Accessed February 26, 2021.
http://hdl.handle.net/10388/12550.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Al-Sakran, Lina H 1982-. “The Epidemiology and Pharmacoepidemiology of Multiple Sclerosis in Saskatchewan.” 2020. Web. 26 Feb 2021.
Vancouver:
Al-Sakran LH1. The Epidemiology and Pharmacoepidemiology of Multiple Sclerosis in Saskatchewan. [Internet] [Thesis]. University of Saskatchewan; 2020. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10388/12550.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Al-Sakran LH1. The Epidemiology and Pharmacoepidemiology of Multiple Sclerosis in Saskatchewan. [Thesis]. University of Saskatchewan; 2020. Available from: http://hdl.handle.net/10388/12550
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
McMaster University
4.
Canning, Karissa L.
Physical Activity and Multiple Sclerosis.
Degree: PhD, 2017, McMaster University
URL: http://hdl.handle.net/11375/22039
► Multiple Sclerosis (MS) is an autoimmune disease characterized by demyelination and axon degeneration of the central nervous system that is accompanied by a wide range…
(more)
▼ Multiple Sclerosis (MS) is an autoimmune disease characterized by demyelination and axon degeneration of the central nervous system that is accompanied by a wide range of symptoms. It is well established that physical activity is associated with a wide variety of health benefits, including improving fitness, MS-related symptoms and function in the MS population. However, despite the potential benefits associated with physical activity participation, most people living with MS remain physically inactive. In 2012, new evidence-based physical activity guidelines (PAGs) for adults with MS were released. The PAGs suggest that for health benefits, adults aged 18-64 years with mild to moderate disability need at least 30 minutes of moderate intensity aerobic physical activity two days per week and strength training for major muscle groups two times per week. The purpose of this dissertation was to determine the association between physical activity and health and to explore physical activity as a potential disease-modifying therapy in the MS population. This was completed through a series of three projects focusing on the PAGs for adults with MS.
The focus of the first study of this dissertation was on the implementation of the PAGs. The results from this study revealed that direct referral to physical activity from a physician is twice as effective as simply providing information about physical activity with respect to adhering to the PAG recommendations in people with MS (65.2 % vs. 32.8 % for direct referral and control groups, respectively). Further, the results revealed that a high self-efficacy for exercise at baseline may be an additional predictor to PAG adherence.
The purpose of the second study of this dissertation was to validate the PAGs for people with MS within a community-based intervention, and to affirm that following the PAGs for 16 weeks would result in improvements in fitness, mobility, fatigue symptoms and quality of life.
The results from the second study confirm the effectiveness of the PAGs for people with MS for improving health, as significant improvements were observed in VO2 peak (+32 %), strength (+8-20 %), mobility (+14 %), fatigue symptoms (-40 %) and quality of life (+10-24 %).
The purpose of the third and final study was to determine the effect of exercise on brain function and cognition in a sample of adults living with MS. Following the PAGs for 16 weeks led to significant improvements in processing speed and memory in adults living with MS.
Overall, the results from this dissertation are extremely promising and highlight the importance of physical activity with respect to improving aspects of health and the effect it can have on MS-related symptoms and cognition in the MS population. Novel findings in this dissertation present convincing evidence that physicians should refer patients with MS to participate in exercise to improve MS-related symptoms and overall well-being.
Thesis
Doctor of Philosophy (PhD)
Advisors/Committee Members: Hicks, Audrey L., Kinesiology.
Subjects/Keywords: Multiple Sclerosis; Exercise
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APA (6th Edition):
Canning, K. L. (2017). Physical Activity and Multiple Sclerosis. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/22039
Chicago Manual of Style (16th Edition):
Canning, Karissa L. “Physical Activity and Multiple Sclerosis.” 2017. Doctoral Dissertation, McMaster University. Accessed February 26, 2021.
http://hdl.handle.net/11375/22039.
MLA Handbook (7th Edition):
Canning, Karissa L. “Physical Activity and Multiple Sclerosis.” 2017. Web. 26 Feb 2021.
Vancouver:
Canning KL. Physical Activity and Multiple Sclerosis. [Internet] [Doctoral dissertation]. McMaster University; 2017. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/11375/22039.
Council of Science Editors:
Canning KL. Physical Activity and Multiple Sclerosis. [Doctoral Dissertation]. McMaster University; 2017. Available from: http://hdl.handle.net/11375/22039
Victoria University of Wellington
5.
Chuluundorj, Delgertsetseg.
Type II Activation of Monocytes in Multiple Sclerosis.
Degree: 2013, Victoria University of Wellington
URL: http://hdl.handle.net/10063/8966
► Multiple sclerosis (MS) is an incurable autoimmune disease of the CNS. Although its cause is not known, immune cells are involved in the disease progression.…
(more)
▼ Multiple sclerosis (MS) is an incurable autoimmune disease of the CNS. Although its cause is not known, immune cells are involved in the disease progression. Among these cells, type I monocytes are first to arrive to the brain and initiate inflammation; however, if monocytes are type II activated, they can inhibit inflammation. Previous research has shown that immune responses can be modulated by treatments, such as glatiramer acetate (GA) and immune complexes (IC). Therefore, we aimed to determine whether GA and IC can induce type II activation of monocytes in MS.
Human blood monocytes from healthy volunteers and MS patients were stimulated in vitro with bacterial lipopolysaccharide (classical activation) in the presence or absence of GA and immune complexes (IC) composed of IVIG and human red blood cells (type II activation). Flow cytometry, ELISA and cytometric bead array were used to assess levels of marker expression and cytokine production in order to define the activation of monocytes.
Interestingly, while both GA and IC induced type II activation of monocytes, the characteristics of these type II monocytes were distinct. We have found that monocytes from both healthy people and MS patients have significantly lower levels of inflammatory marker CD40 and higher levels of the anti-inflammatory cytokine IL-10 after treatment with IC. In contrast, GA treatment reduced the levels of CD40, CD86 and the inflammatory cytokine IL- 12. Moreover, the combined addition of GA and IC appeared to be more effective in type II activating monocytes than either agent alone. We also found that both CD14++CD16- and CD14+CD16+ monocyte subsets can be type II activated by the treatments; however, an interaction between the subsets impaired their response to the treatments.
Our study suggests that treatments with GA and IC, especially in combination, are effective in type II activation of human monocytes and can be beneficial therapeutic approaches for
multiple sclerosis.
Advisors/Committee Members: La Flamme, Anne, Harding, Scott.
Subjects/Keywords: Monocytes; Multiple sclerosis
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APA (6th Edition):
Chuluundorj, D. (2013). Type II Activation of Monocytes in Multiple Sclerosis. (Doctoral Dissertation). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/8966
Chicago Manual of Style (16th Edition):
Chuluundorj, Delgertsetseg. “Type II Activation of Monocytes in Multiple Sclerosis.” 2013. Doctoral Dissertation, Victoria University of Wellington. Accessed February 26, 2021.
http://hdl.handle.net/10063/8966.
MLA Handbook (7th Edition):
Chuluundorj, Delgertsetseg. “Type II Activation of Monocytes in Multiple Sclerosis.” 2013. Web. 26 Feb 2021.
Vancouver:
Chuluundorj D. Type II Activation of Monocytes in Multiple Sclerosis. [Internet] [Doctoral dissertation]. Victoria University of Wellington; 2013. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10063/8966.
Council of Science Editors:
Chuluundorj D. Type II Activation of Monocytes in Multiple Sclerosis. [Doctoral Dissertation]. Victoria University of Wellington; 2013. Available from: http://hdl.handle.net/10063/8966
University of Debrecen
6.
Ales, Maria Elena.
Emerging Pharmacotherapy of Multiple Sclerosis
.
Degree: DE – Általános Orvostudományi Kar, 2014, University of Debrecen
URL: http://hdl.handle.net/2437/194729
Subjects/Keywords: Multiple sclerosis;
pharmacotherapy
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APA (6th Edition):
Ales, M. E. (2014). Emerging Pharmacotherapy of Multiple Sclerosis
. (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/194729
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ales, Maria Elena. “Emerging Pharmacotherapy of Multiple Sclerosis
.” 2014. Thesis, University of Debrecen. Accessed February 26, 2021.
http://hdl.handle.net/2437/194729.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ales, Maria Elena. “Emerging Pharmacotherapy of Multiple Sclerosis
.” 2014. Web. 26 Feb 2021.
Vancouver:
Ales ME. Emerging Pharmacotherapy of Multiple Sclerosis
. [Internet] [Thesis]. University of Debrecen; 2014. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/2437/194729.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ales ME. Emerging Pharmacotherapy of Multiple Sclerosis
. [Thesis]. University of Debrecen; 2014. Available from: http://hdl.handle.net/2437/194729
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Debrecen
7.
Wieczorek, Deborah.
New oral immunomodulatory agents in the treatment of Relapsing-Remitting Multiple Sclerosis
.
Degree: DE – Általános Orvostudományi Kar, 2014, University of Debrecen
URL: http://hdl.handle.net/2437/194721
► The thesis talks about the newest oral immunomodulatory agents in the treatment of Multiple Sclerosis since its introduction in the year 2010 with focus on…
(more)
Subjects/Keywords: Multiple Sclerosis;
Treatment
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APA ·
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APA (6th Edition):
Wieczorek, D. (2014). New oral immunomodulatory agents in the treatment of Relapsing-Remitting Multiple Sclerosis
. (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/194721
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wieczorek, Deborah. “New oral immunomodulatory agents in the treatment of Relapsing-Remitting Multiple Sclerosis
.” 2014. Thesis, University of Debrecen. Accessed February 26, 2021.
http://hdl.handle.net/2437/194721.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wieczorek, Deborah. “New oral immunomodulatory agents in the treatment of Relapsing-Remitting Multiple Sclerosis
.” 2014. Web. 26 Feb 2021.
Vancouver:
Wieczorek D. New oral immunomodulatory agents in the treatment of Relapsing-Remitting Multiple Sclerosis
. [Internet] [Thesis]. University of Debrecen; 2014. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/2437/194721.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wieczorek D. New oral immunomodulatory agents in the treatment of Relapsing-Remitting Multiple Sclerosis
. [Thesis]. University of Debrecen; 2014. Available from: http://hdl.handle.net/2437/194721
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Bridgeport
8.
Fiorentino, Salvatore Jr.
Safe and Effective Natural Ways to Prevent and Treat Multiple Sclerosis
.
Degree: 2013, University of Bridgeport
URL: https://scholarworks.bridgeport.edu/xmlui/handle/123456789/1403
► Presently, Multiple Sclerosis is considered to be an autoimmune disorder. The myelin sheath is thought to be attacked by the body’s own immune system leading…
(more)
▼ Presently, Multiple Sclerosis is considered to be an autoimmune disorder. The myelin sheath is thought to be attacked by the body’s own immune system leading to many neurological effects. Conventional medicine has mostly used immune suppressing drugs to treat this disorder, but all drugs have side effects that can be even more deadly than the disorder itself. The purpose of this paper is to determine if there are truly safe and effective natural ways to prevent and treat multiple sclerosis. This paper demonstrates that there are many natural ways to prevent and treat multiple sclerosis. For example, prevention and treatments include heavy metal chelation, using lipoic acid, fish oil, quercetin, curcumin, DHEA, cannabis, Horse chestnut and Gotu kola, but perhaps the one single most important way to prevent multiple sclerosis is through the intake of adequate amounts of vitamin D during pregnancy and throughout one’s life. CCSVI and Centella in combination were only somewhat touched upon in this research paper, but may have an important link to the development and progression of this disorder.
Subjects/Keywords: Naturopathy;
Multiple sclerosis
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Manager
APA (6th Edition):
Fiorentino, S. J. (2013). Safe and Effective Natural Ways to Prevent and Treat Multiple Sclerosis
. (Thesis). University of Bridgeport. Retrieved from https://scholarworks.bridgeport.edu/xmlui/handle/123456789/1403
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Fiorentino, Salvatore Jr. “Safe and Effective Natural Ways to Prevent and Treat Multiple Sclerosis
.” 2013. Thesis, University of Bridgeport. Accessed February 26, 2021.
https://scholarworks.bridgeport.edu/xmlui/handle/123456789/1403.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Fiorentino, Salvatore Jr. “Safe and Effective Natural Ways to Prevent and Treat Multiple Sclerosis
.” 2013. Web. 26 Feb 2021.
Vancouver:
Fiorentino SJ. Safe and Effective Natural Ways to Prevent and Treat Multiple Sclerosis
. [Internet] [Thesis]. University of Bridgeport; 2013. [cited 2021 Feb 26].
Available from: https://scholarworks.bridgeport.edu/xmlui/handle/123456789/1403.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Fiorentino SJ. Safe and Effective Natural Ways to Prevent and Treat Multiple Sclerosis
. [Thesis]. University of Bridgeport; 2013. Available from: https://scholarworks.bridgeport.edu/xmlui/handle/123456789/1403
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Limerick
9.
Garrett, Maria.
Physiotherapy and exercise interventions for people with multiple sclerosis with minimal gait impairment.
Degree: 2011, University of Limerick
URL: http://hdl.handle.net/10344/1664
► peer-reviewed
Multiple Sclerosis (MS) is a demyelinating, degenerative disease of themcentral nervous system. It is the leading cause of disability in young adults for which…
(more)
▼ peer-reviewed
Multiple Sclerosis (MS) is a demyelinating, degenerative disease of themcentral nervous system. It is the leading cause of disability in young adults for which
there is no cure. In a disease that has no cure, minimising its impact is arguably the
main goal of intervention.
The literature review demonstrated that exercise results in many important
outcomes for People with MS (PwMS) with minimal gait impairment. However no
community-based interventions have been evaluated.
A large (N = 372), multi-centred, block-randomised, waiting list controlled
trial was conducted with the primary objective of establishing the efficacy of three community-based exercise interventions. These were Physiotherapy (PT)-led exercise, Yoga and Fitness Instructor (FI)-led exercise delivered over an hour a week for ten weeks. The second objective was to establish if there was a difference
between interventions. The third objective was to investigate the results at 3-month
follow-up. The final objective was to establish predictors of outcome after the
intervention period. Outcomes used were the Multiple Sclerosis Impact Scale-29, v 2
(MSIS-29, v2), the Modified Fatigue Impact Scale (MFIS) and the Six Minute Walk
Test (6MWT).
This study found that there was a significant improvement in the MSIS-29, v2
and the MFIS due to all interventions (p<0.05) and no change in the control. There
was a significant improvement in the 6MWT due to PT-led and FI-led exercise
interventions. There was no change in 6MWT in the Yoga group (p>0.05) and a
trend towards worsening in the control. There were significant differences between
the PT-led group and yoga (p<0.05) and FI-led exercise and yoga (p<0.05). At 3
month follow-up there was a statistically significant worsening of all of the positive
findings. However outcomes remained significantly improved from baseline for the
MSIS-29, v 2 (psychological component) and for the MFIS (p<0.05). Fifty-seven per
cent of the variance in outcome was accounted for through five predictor variables.
This study demonstrated important outcomes for PwMS. These findings
suggest that some of the needs for PwMS with minimal gait impairment can be met in community settings which may ease the burden of health service delivery. This challenges the current model of one to one pysiotherapy in a medical setting.
Future research should attend to developing interventions to increase long term
exercise participation and explore other variables that may influence outcome.
Advisors/Committee Members: Coote, Susan, Jakeman, Philip M..
Subjects/Keywords: multiple sclerosis; exercise
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APA (6th Edition):
Garrett, M. (2011). Physiotherapy and exercise interventions for people with multiple sclerosis with minimal gait impairment. (Thesis). University of Limerick. Retrieved from http://hdl.handle.net/10344/1664
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Garrett, Maria. “Physiotherapy and exercise interventions for people with multiple sclerosis with minimal gait impairment.” 2011. Thesis, University of Limerick. Accessed February 26, 2021.
http://hdl.handle.net/10344/1664.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Garrett, Maria. “Physiotherapy and exercise interventions for people with multiple sclerosis with minimal gait impairment.” 2011. Web. 26 Feb 2021.
Vancouver:
Garrett M. Physiotherapy and exercise interventions for people with multiple sclerosis with minimal gait impairment. [Internet] [Thesis]. University of Limerick; 2011. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10344/1664.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Garrett M. Physiotherapy and exercise interventions for people with multiple sclerosis with minimal gait impairment. [Thesis]. University of Limerick; 2011. Available from: http://hdl.handle.net/10344/1664
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Limerick
10.
Hughes, Lonan.
The effects of adding a neuromuscular electrical stimulation device to a progressive resistance training programme in people with multiple sclerosis.
Degree: 2011, University of Limerick
URL: http://hdl.handle.net/10344/1676
► peer-reviewed
Background: Multiple Scelrosis (MS) is a progressive demyelinating disease of the central nervous system. It is recognised that people with MS (PwMS) who require…
(more)
▼ peer-reviewed
Background: Multiple Scelrosis (MS) is a progressive demyelinating disease of the central nervous system. It is recognised that people with MS (PwMS) who require a mobility aid, experience higher levels of disability, compared to those without mobility impairment. Decreased strength of the lower limbs is a primary problem, which is clinically associated with functional limitations in MS.
Progressive resistance training (PRT) and neuromuscular electrical stimulation
(NMES), to a lesser degree, are effective rehabilitation strategies to improve
strength and function in PwMS. Presently, there is limited literature to support
superimposing NMES on PRT in PwMS, particularly in the home-setting. The
clinical profile literature of PwMS who use a walking aid, is also limited.
Aims: The primary aim of this thesis was to investigate the effects of adding an
NMES device (Kneehab) to a home-based PRT in PwMS who use a walking aid. Secondary aims included, evaluating the clinical profile of this population and determining participant satisfaction with the Kneehab device.
Methods: The study used a randomised design to compare 12 weeks of homebased
PRT to the same with superimposed NMES. The Kneehab device is designed for the quadriceps. The study assessor was blinded to group allocation.
Participants were evaluated at week 0, 6 and 12 for a number of important clinical problems that were identified in the literature review. These included
quadriceps strength (primary outcome), quadriceps thickness and endurance,
spasticity, balance, mobility, health-related quality of life (HRQoL) and fatigue.
Participants in the Kneehab group completed a device satisfaction questionnaire.
Results: Thirty-seven PwMS participated in the study. The baseline data for
this group showed that muscle weakness, balance and mobility limitations were
severe problems. Moderate correlations between quadriceps endurance and
balance (r=0.692), and quadriceps endurance and mobility (r=-0.583) were
shown. Twenty-five participants completed the study (PRT n=10; Kneehab n=15). Two-drop-outs in the Kneehab group were due to muscle spasm induced by the device. In both groups, quadriceps strength increased non-significantly while balance and gluteal strength improved significantly (p<0.05). The
Kneehab group improved significantly on plantar-flexion strength, rectus femoris thickness, quadriceps endurance, perceived spasticity, HRQoL ad fatigue (all p<0.05). The plantar-flexion strength, spasticity, HRQoL and fatigue improvements in the Kneehab group were significantly greater than the PRT group (all p<0.05). The Kneehab group also completed significantly more
sessions, and total and quadriceps work (all p<0.05). Participants were satisfied with the usability and value of having the Kneehab device.
Conclusion: This preliminary research indicates that adding an NMES device
to a PRT programme for PwMS who use a walking aid results in better
outcomes than PRT alone. This may be due to a placebo type effect, whereby
participants…
Advisors/Committee Members: Coote, Susan, Donnelly, Alan Edward, IRCSET.
Subjects/Keywords: multiple sclerosis; mobility
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APA (6th Edition):
Hughes, L. (2011). The effects of adding a neuromuscular electrical stimulation device to a progressive resistance training programme in people with multiple sclerosis. (Thesis). University of Limerick. Retrieved from http://hdl.handle.net/10344/1676
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hughes, Lonan. “The effects of adding a neuromuscular electrical stimulation device to a progressive resistance training programme in people with multiple sclerosis.” 2011. Thesis, University of Limerick. Accessed February 26, 2021.
http://hdl.handle.net/10344/1676.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hughes, Lonan. “The effects of adding a neuromuscular electrical stimulation device to a progressive resistance training programme in people with multiple sclerosis.” 2011. Web. 26 Feb 2021.
Vancouver:
Hughes L. The effects of adding a neuromuscular electrical stimulation device to a progressive resistance training programme in people with multiple sclerosis. [Internet] [Thesis]. University of Limerick; 2011. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10344/1676.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hughes L. The effects of adding a neuromuscular electrical stimulation device to a progressive resistance training programme in people with multiple sclerosis. [Thesis]. University of Limerick; 2011. Available from: http://hdl.handle.net/10344/1676
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Aberdeen
11.
Visser, Elizabeth Magdalena.
The prevalence of multiple sclerosis in the North of Scotland.
Degree: Thesis (M.D.), 2013, University of Aberdeen
URL: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153235690005941
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619173
► Background: Multiple sclerosis (MS) is a common, disabling neuro-inflammatory disorder, whose prevalence seems to be increasing. Objectives: The main aims of this thesis were to:…
(more)
▼ Background: Multiple sclerosis (MS) is a common, disabling neuro-inflammatory disorder, whose prevalence seems to be increasing. Objectives: The main aims of this thesis were to: (i) systematically review good quality MS prevalence studies and assess heterogeneity in prevalence rates; (ii) conduct a new prevalence study in Aberdeen, Orkney and Shetland to assess temporal trends, compare rates to other areas and describe demographic, clinical and disability data in prevalent MS patients. Methods: The systematic review used defined search strategies to identify references that satisfied inclusion criteria. The influence of time, latitude, diagnostic criteria, quality of case ascertainment and methods of classifying patients on age-gender standardised prevalence rates and sex ratios were analysed by uni- and multivariate regression. The new prevalence study identified all MS patients alive on 24/9/09 from defined general practices through multiple sources. Primary and secondary care records were used to confirm the diagnosis. Prevalence rates were standardised to 2009 Scottish population. A postal questionnaire survey was conducted to gain additional data, which allowed a randomised factorial trial of the effect of envelope colour/address labelling on response rates to be performed. Results: The review identified marked heterogeneity (I2 99.7%) in prevalence rates, partially explained by latitude (p<0.0001), prevalence date (p=0.009) and number of ascertainment sources (p=0.04). High and rising prevalence was recorded in Orkney [402/100,000 (95% CI 319-500)], the highest worldwide, Shetland [295/100,000 (95%CI 229-375)] and Aberdeen city [229/100,000 (95%CI 208-250)]. Male-to-female ratio was 1:2.55 (95%CI 2.26-2.89). Postal response rates to brown/white envelopes were not different [OR 1.17 (95% CI 0.81 to 1.68)] but hand-written address labels had a higher response than computer-generated labels [OR 1.22 (95% CI 1.06-1.40)]. Conclusions: This research showed that MS prevalence remains very high in northern Scotland and confirmed international observations of rising prevalence. Explanations include increased survival, improved diagnosis and probably increasing incidence.
Subjects/Keywords: 616.8; Multiple sclerosis
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APA (6th Edition):
Visser, E. M. (2013). The prevalence of multiple sclerosis in the North of Scotland. (Doctoral Dissertation). University of Aberdeen. Retrieved from https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153235690005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619173
Chicago Manual of Style (16th Edition):
Visser, Elizabeth Magdalena. “The prevalence of multiple sclerosis in the North of Scotland.” 2013. Doctoral Dissertation, University of Aberdeen. Accessed February 26, 2021.
https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153235690005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619173.
MLA Handbook (7th Edition):
Visser, Elizabeth Magdalena. “The prevalence of multiple sclerosis in the North of Scotland.” 2013. Web. 26 Feb 2021.
Vancouver:
Visser EM. The prevalence of multiple sclerosis in the North of Scotland. [Internet] [Doctoral dissertation]. University of Aberdeen; 2013. [cited 2021 Feb 26].
Available from: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153235690005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619173.
Council of Science Editors:
Visser EM. The prevalence of multiple sclerosis in the North of Scotland. [Doctoral Dissertation]. University of Aberdeen; 2013. Available from: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153235690005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619173
Dalhousie University
12.
Webber, Kristine.
Health Promotion Experiences and Ideas for Health Promotion
Improvements: An Interpretative Phenomenological Study of Nova
Scotian Women with Multiple Sclerosis Through a Feminist,
Disability Rights Lens.
Degree: MA, School of Health & Human Performance, 2014, Dalhousie University
URL: http://hdl.handle.net/10222/54050
► Most research in health promotion uses quantitative methodology to better understand the health promotion experiences of people with disabilities. This qualitative thesis study used Interpretative…
(more)
▼ Most research in health promotion uses quantitative
methodology to better understand the health promotion experiences
of people with disabilities. This qualitative thesis study used
Interpretative Phenomenologist Analysis and semi-structured
interviews as the study method. Six women with MS, aged 44 to 64,
were recruited from a
Multiple Sclerosis, outpatient clinic, in
Halifax, Nova Scotia. Participants shared background and health
promotion experiences of MS and their ideas for health promotion
improvements. Four themes were constructed from the data including:
contextual experiences; health promotion participation; health
promotion challenges and strategies and; health promotion
improvements. Results provide rich description, of participants
experiences of MS and health promotion participation, their
suggestions for improvements and implications for health promotion
and future research.
Advisors/Committee Members: Heidi Lauckner (external-examiner), Lynne Robinson (graduate-coordinator), Judy MacDonald (thesis-reader), Debbie Martin (thesis-reader), Christine Short (thesis-reader), Susan Hutchinson (thesis-supervisor), Received (ethics-approval), Not Applicable (manuscripts), Not Applicable (copyright-release).
Subjects/Keywords: Multiple Sclerosis; Health Promotion
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APA (6th Edition):
Webber, K. (2014). Health Promotion Experiences and Ideas for Health Promotion
Improvements: An Interpretative Phenomenological Study of Nova
Scotian Women with Multiple Sclerosis Through a Feminist,
Disability Rights Lens. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/54050
Chicago Manual of Style (16th Edition):
Webber, Kristine. “Health Promotion Experiences and Ideas for Health Promotion
Improvements: An Interpretative Phenomenological Study of Nova
Scotian Women with Multiple Sclerosis Through a Feminist,
Disability Rights Lens.” 2014. Masters Thesis, Dalhousie University. Accessed February 26, 2021.
http://hdl.handle.net/10222/54050.
MLA Handbook (7th Edition):
Webber, Kristine. “Health Promotion Experiences and Ideas for Health Promotion
Improvements: An Interpretative Phenomenological Study of Nova
Scotian Women with Multiple Sclerosis Through a Feminist,
Disability Rights Lens.” 2014. Web. 26 Feb 2021.
Vancouver:
Webber K. Health Promotion Experiences and Ideas for Health Promotion
Improvements: An Interpretative Phenomenological Study of Nova
Scotian Women with Multiple Sclerosis Through a Feminist,
Disability Rights Lens. [Internet] [Masters thesis]. Dalhousie University; 2014. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10222/54050.
Council of Science Editors:
Webber K. Health Promotion Experiences and Ideas for Health Promotion
Improvements: An Interpretative Phenomenological Study of Nova
Scotian Women with Multiple Sclerosis Through a Feminist,
Disability Rights Lens. [Masters Thesis]. Dalhousie University; 2014. Available from: http://hdl.handle.net/10222/54050
University of Tasmania
13.
Savage, Kathryn T.
The evaluation of a therapeutic group for multiple sclerosis sufferers.
Degree: 1995, University of Tasmania
URL: https://eprints.utas.edu.au/21507/1/whole_SavageKathrynT1995_thesis.pdf
Subjects/Keywords: Multiple sclerosis
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APA (6th Edition):
Savage, K. T. (1995). The evaluation of a therapeutic group for multiple sclerosis sufferers. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/21507/1/whole_SavageKathrynT1995_thesis.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Savage, Kathryn T. “The evaluation of a therapeutic group for multiple sclerosis sufferers.” 1995. Thesis, University of Tasmania. Accessed February 26, 2021.
https://eprints.utas.edu.au/21507/1/whole_SavageKathrynT1995_thesis.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Savage, Kathryn T. “The evaluation of a therapeutic group for multiple sclerosis sufferers.” 1995. Web. 26 Feb 2021.
Vancouver:
Savage KT. The evaluation of a therapeutic group for multiple sclerosis sufferers. [Internet] [Thesis]. University of Tasmania; 1995. [cited 2021 Feb 26].
Available from: https://eprints.utas.edu.au/21507/1/whole_SavageKathrynT1995_thesis.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Savage KT. The evaluation of a therapeutic group for multiple sclerosis sufferers. [Thesis]. University of Tasmania; 1995. Available from: https://eprints.utas.edu.au/21507/1/whole_SavageKathrynT1995_thesis.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
14.
Karagiannis, Fotios.
Ταυτοποίηση μεταγραφικών παραγόντων που ρυθμίζουν την έκφραση κυτταροκινών σε αναπτυσσόμενα Τ κύτταρα.
Degree: 2016, University of Patras; Πανεπιστήμιο Πατρών
URL: http://hdl.handle.net/10442/hedi/41759
► The activation and differentiation of naive T helper (Th) cells into distinct functional subpopulations is crucial for the effective defence and immune-regulation of the organism.…
(more)
▼ The activation and differentiation of naive T helper (Th) cells into distinct functional subpopulations is crucial for the effective defence and immune-regulation of the organism. These subpopulations are considered different cell lineages and are defined by the expression of specific cytokines and transcription factors. When naïve Th cells are activated, through their TCR receptor, they are differentiated into dividing pre-Th0 proliferating precursors, before their differentiation to one of the Th effector subpopulations. The first cytokine that is produced during this process is IL-2, which is responsible for the proliferation and clonal expansion of T lymphocytes.The purpose of this thesis is to study the regulation of IL-2 expression in naive Th cells, through the binding of transcription factors onto the promoter of the IL-2 gene. In particular, we will examine the role of the transcription factor Ets-2 in the regulation of IL-2 expression in naive Th cells, in contrast with the well-studied transcription factors NFAT and Foxp3, which have the same binding site on the promoter of the IL- 2 gene, and also the correlation of Ets-2 with the pathogenesis of the autoimmune disease, Multiple Sclerosis.We have shown a different expression pattern of Ets-2 between Th cells with different levels of activation and human lymphoid organs and with the factors NFAT and Foxp3. In naïve Th cells of healthy donors, mRNA and protein expression levels and binding ability to the ARRE-2 element of the IL-2 gene promoter, are reduced after the activation of the cells, followed by an increase in the IL-2 expression. The binding ability of Ets-2 to the ARRE-2 element of the IL-2 gene promoter is stronger in naïve Th cells compared to activated naïve and memory Th cells.On the other hand, in cells obtained from patients with Multiple Sclerosis, the expression levels of Ets-2 were low both in naïve and memory Th cells. In contrast, these cells show an increased expression of IL-2 compared to those from healthy donors. It was also shown that Ets-2 doesn’t bind onto the ARRE-2 element of the IL- 2 gene promoter in patients’ cells. This silencing activity disappears in activated or memory Th cells. At the same time expression of Foxp3 is reduced in T regulatory cells of patients compared to those of healthy donors.Therefore we suggest that Ets-2 expression and protein binding to the ARRE-2 element of the IL-2 promoter are part of a strictly regulated process that results in a physiological transition of naive Th cells to Th0 cells upon antigenic stimulation. Low- level synthesis and dysfunction of Ets-2 and FoxP3 in Th cells of MS patients are probably responsible for the increase in pathological Th cell clones.
Η ενεργοποίηση και διαφοροποίηση των παρθενικών Τ βοηθητικών (Th) λεμφοκυττάρων σε διακριτούς λειτουργικούς υποπληθυσμούς είναι κρίσιμη για τη σωστή άμυνα και ανοσορύθμιση του οργανισμού. Οι υποπληθυσμοί αυτοί θεωρούνται ως διαφορετικές γενιές κυττάρων και καθορίζονται από την έκφραση συγκεκριμένων…
Subjects/Keywords: Σκλήρυνση κατά πλάκας; Multiple sclerosis
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APA (6th Edition):
Karagiannis, F. (2016). Ταυτοποίηση μεταγραφικών παραγόντων που ρυθμίζουν την έκφραση κυτταροκινών σε αναπτυσσόμενα Τ κύτταρα. (Thesis). University of Patras; Πανεπιστήμιο Πατρών. Retrieved from http://hdl.handle.net/10442/hedi/41759
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Karagiannis, Fotios. “Ταυτοποίηση μεταγραφικών παραγόντων που ρυθμίζουν την έκφραση κυτταροκινών σε αναπτυσσόμενα Τ κύτταρα.” 2016. Thesis, University of Patras; Πανεπιστήμιο Πατρών. Accessed February 26, 2021.
http://hdl.handle.net/10442/hedi/41759.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Karagiannis, Fotios. “Ταυτοποίηση μεταγραφικών παραγόντων που ρυθμίζουν την έκφραση κυτταροκινών σε αναπτυσσόμενα Τ κύτταρα.” 2016. Web. 26 Feb 2021.
Vancouver:
Karagiannis F. Ταυτοποίηση μεταγραφικών παραγόντων που ρυθμίζουν την έκφραση κυτταροκινών σε αναπτυσσόμενα Τ κύτταρα. [Internet] [Thesis]. University of Patras; Πανεπιστήμιο Πατρών; 2016. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10442/hedi/41759.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Karagiannis F. Ταυτοποίηση μεταγραφικών παραγόντων που ρυθμίζουν την έκφραση κυτταροκινών σε αναπτυσσόμενα Τ κύτταρα. [Thesis]. University of Patras; Πανεπιστήμιο Πατρών; 2016. Available from: http://hdl.handle.net/10442/hedi/41759
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Saskatchewan
15.
Alphonsus, Khrisha B 1989-.
MULTIPLE SCLEROSIS: RISK PERCEPTION, SYMPTOMS AND TREATMENT.
Degree: 2019, University of Saskatchewan
URL: http://hdl.handle.net/10388/12205
► Multiple sclerosis (MS) is a neurological disease of the central nervous system which causes the nerves to deteriorate over time. MS affects individuals between the…
(more)
▼ Multiple sclerosis (MS) is a neurological disease of the central nervous system which causes the nerves to deteriorate over time. MS affects individuals between the ages of 20 to 45 years of age and both biological and environmental factors are associated with the disease. Canada has one of the highest rates of MS in the world along with several European countries. The definitive cause and cure for MS had not been determined and because of this the quality of life of people living with MS is poor. This thesis investigates the following topics: population awareness about second hand smoke exposure and its association with MS; the importance of having social support and its effect on managing pain in MS; medication use; and the effectiveness of exercise in improving the physical, mental and social quality of life of people living with MS.
The analysis shows that there was a lack of knowledge in second hand smoke exposure and risk of MS development in the Canadian population. Individual responses in agreeing or disagreeing to whether second hand smoke exposure was a risk factor for MS varied based on the provinces in which respondents resided, demographic factors, having a member of the household smoke inside the home and whether the respondents were bothered by second hand smoking.
Analysis of national survey data of people living with MS found that having social support was beneficial for reducing pain. Having someone to take you to the doctor, confide/talk to, to do something enjoyable with and to take you to the emergency was found to be significantly associated with a lower reporting of pain. In a separate analysis, using complementary treatment for MS was associated with lower odds of medication use. The use of behavior modification models as a tool for medication adherence is important for individuals living with chronic conditions who have a hard time coping with change.
In an analysis of the effect of complementary therapies on MS, aerobic exercise such as treadmill training, cycling, aquatic exercise and high intensity interval training and physiotherapy was found to have greater effect on physical, mental and social health as opposed to other types of complementary treatments.
Advisors/Committee Members: D'Arcy , Carl, Lepnurm , Rein, Walz, Wolfgang, Feng , Cindy, Meng , Xiangfei.
Subjects/Keywords: Multiple sclerosis; risks; symptoms; treatments
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APA (6th Edition):
Alphonsus, K. B. 1. (2019). MULTIPLE SCLEROSIS: RISK PERCEPTION, SYMPTOMS AND TREATMENT. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/12205
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Alphonsus, Khrisha B 1989-. “MULTIPLE SCLEROSIS: RISK PERCEPTION, SYMPTOMS AND TREATMENT.” 2019. Thesis, University of Saskatchewan. Accessed February 26, 2021.
http://hdl.handle.net/10388/12205.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Alphonsus, Khrisha B 1989-. “MULTIPLE SCLEROSIS: RISK PERCEPTION, SYMPTOMS AND TREATMENT.” 2019. Web. 26 Feb 2021.
Vancouver:
Alphonsus KB1. MULTIPLE SCLEROSIS: RISK PERCEPTION, SYMPTOMS AND TREATMENT. [Internet] [Thesis]. University of Saskatchewan; 2019. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10388/12205.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Alphonsus KB1. MULTIPLE SCLEROSIS: RISK PERCEPTION, SYMPTOMS AND TREATMENT. [Thesis]. University of Saskatchewan; 2019. Available from: http://hdl.handle.net/10388/12205
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Johannesburg
16.
Knipe, Irene Mary.
An exploratory study to establish the effect of a homoeopathic complex remedy in the treatment of multiple sclerosis.
Degree: 2009, University of Johannesburg
URL: http://hdl.handle.net/10210/2590
M.Tech.
Subjects/Keywords: Multiple sclerosis
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APA (6th Edition):
Knipe, I. M. (2009). An exploratory study to establish the effect of a homoeopathic complex remedy in the treatment of multiple sclerosis. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/2590
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Knipe, Irene Mary. “An exploratory study to establish the effect of a homoeopathic complex remedy in the treatment of multiple sclerosis.” 2009. Thesis, University of Johannesburg. Accessed February 26, 2021.
http://hdl.handle.net/10210/2590.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Knipe, Irene Mary. “An exploratory study to establish the effect of a homoeopathic complex remedy in the treatment of multiple sclerosis.” 2009. Web. 26 Feb 2021.
Vancouver:
Knipe IM. An exploratory study to establish the effect of a homoeopathic complex remedy in the treatment of multiple sclerosis. [Internet] [Thesis]. University of Johannesburg; 2009. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10210/2590.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Knipe IM. An exploratory study to establish the effect of a homoeopathic complex remedy in the treatment of multiple sclerosis. [Thesis]. University of Johannesburg; 2009. Available from: http://hdl.handle.net/10210/2590
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
17.
Saenz, Amaya.
Mémoire et sclérose en plaques : Memory and multiple sclerosis.
Degree: Docteur es, Neuropsychologie, 2014, Lille 3
URL: http://www.theses.fr/2014LIL30055
► Cette thèse propose d'explorer les capacités en mémoire épisodique de patients atteints de sclérose en plaques (sep). A notre connaissance, l'analyse des processus touchés et…
(more)
▼ Cette thèse propose d'explorer les capacités en mémoire épisodique de patients atteints de sclérose en plaques (sep). A notre connaissance, l'analyse des processus touchés et préservés a fait l'objet de peu de travaux. L'une des raisons historiques semble être la création, dès les années 1980, de batteries d'évaluation rapide destinées aux neurologues. Ainsi, le golden standard de l'évaluation mnésique dans cette affection est le srt (dujardin et al., 2004) qui permet difficilement de contrôler les troubles d'encodage et de récupération. L'objectif de cette thèse sera dans un premier temps de documenter à l'aide d'épreuves permettant une analyse des processus mnésiques, les capacités de mémoire épisodique verbale dans la sep. Les performances de trois groupes de patients (sep, maladies d'Alzheimer et de Parkinson) seront comparées dans l'épreuve rl/ri-16 items. Cette étude sera destinée à vérifier si une majorité de patients sep présente une amélioration du rappel libre après délai contrairement aux deux autres affections testées. Si tel est le cas, l'hypothèse d'un temps de traitement, insuffisamment long pour les patients sep entre les rappels immédiats, mériterait d'être testée. Pour cela, une version parallèle du cvlt sera créée. Ainsi, les performances des patients seront comparées intra-individuellement lors de l'administration de l'épreuve dans sa version originale et lors d'une version où les temps entre les présentations de la liste de courses seront allongés. Un troisième volet sera destiné à tester les capacités de consolidation à long terme (une étude dans ce domaine pour la sep). Une analyse anatomo-fonctionnelle sera conduite en éprouvant l'hypothèse d'un lien entre les performances de rappel à une semaine et la volumétrie hippocampique des patients sep.
This thesis suggests exploring capacities in memory episodic of patients reached by multiple sclerosis. To our knowledge, the analysis of the affected and protected processes was the object of few works. One of the historic reasons seems to be the creation, from the 1980s, of batteries of fast evaluation intended for the neurologists. So, standard Golden of the mnesic evaluation in this affection is the srt (dujardin and al ., on 2004) which allows with difficulty to check) the disorders of encoding and recovery. The objective of this thesis will at first be to document by means of tests allowing an analysis of the mnesic processes, capacities of verbal episodic memory in frog. The performances of three groups of patients (frog, Alzheimer's diseases and of Parkinson) will be compared in the test rl / ri-16 items. This study will be intended to verify if a majority of patients frog presents an improvement of the free reminder after deadline contrary to two other tested affections. If that was the case, the hypothesis of a processing time, insufficiently long for the patients frog between the immediate reminders), would deserve to be tested. For that purpose, a parallel version of the cvlt will be created. So, the performances of the patients will be…
Advisors/Committee Members: Samson, Séverine (thesis director), Ehrlé, Nathalie (thesis director).
Subjects/Keywords: Sclérose en plaques; Multiple sclerosis
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APA (6th Edition):
Saenz, A. (2014). Mémoire et sclérose en plaques : Memory and multiple sclerosis. (Doctoral Dissertation). Lille 3. Retrieved from http://www.theses.fr/2014LIL30055
Chicago Manual of Style (16th Edition):
Saenz, Amaya. “Mémoire et sclérose en plaques : Memory and multiple sclerosis.” 2014. Doctoral Dissertation, Lille 3. Accessed February 26, 2021.
http://www.theses.fr/2014LIL30055.
MLA Handbook (7th Edition):
Saenz, Amaya. “Mémoire et sclérose en plaques : Memory and multiple sclerosis.” 2014. Web. 26 Feb 2021.
Vancouver:
Saenz A. Mémoire et sclérose en plaques : Memory and multiple sclerosis. [Internet] [Doctoral dissertation]. Lille 3; 2014. [cited 2021 Feb 26].
Available from: http://www.theses.fr/2014LIL30055.
Council of Science Editors:
Saenz A. Mémoire et sclérose en plaques : Memory and multiple sclerosis. [Doctoral Dissertation]. Lille 3; 2014. Available from: http://www.theses.fr/2014LIL30055
Victoria University of Wellington
18.
Templeton, Nicola.
The effect of clozapine and MIS416 on demyelination, remyelination and immunomodulation in the murine cuprizone model.
Degree: 2017, Victoria University of Wellington
URL: http://hdl.handle.net/10063/6439
► Multiple Sclerosis (MS) is a disorder of the central nervous system that affects approximately 2.5 million people worldwide. Due to the heterogeneous nature of the…
(more)
▼ Multiple Sclerosis (MS) is a disorder of the central nervous system that affects approximately 2.5 million people worldwide. Due to the heterogeneous nature of the disease, and the want of an identified cause, treatment of MS remains difficult. Treatments are available, however these are limited in efficacy and are not suitable for all forms of MS. Disease pathology is characterised by the formation of demyelinating lesions in the central nervous system (CNS) which lead to cognitive and motor impairments associated with the disease. These CNS lesions can be classified as those with immune cell involvement or those without immune cell infiltrate, which are more commonly seen in progressive forms of MS, and currently, there are no treatments available for progressive MS.
Due to the limited options available for treating progressive MS, this thesis aims to identify the therapeutic effect provided by the immunomodulatory compounds, MIS416 and clozapine, in a non-immune mediated model of MS, which is believed to more closely resemble progressive disease. Both of these compounds have been shown previously to reduce disease burden in an immune-driven animal model of MS. To investigate the effect of immune-modulating therapies on lesions without immune cell infiltrate, the cuprizone model of non-immune demyelination was used.
In summary, the work presented in this thesis found that treatment with MIS416 and clozapine led to improved performance on behavioural assays, although neither agent inhibited cuprizone-induced demyelination or enhanced remyelination. The cellular mechanism behind the observed behavioural improvement is yet to be confirmed. MIS416 was able to maintain its previously identified immunomodulatory properties when administered in this novel setting. Moreover, novel changes to serum growth factors were identified that could provide unexpected benefit to MS patients administered MIS416. In addition to reversing cuprizone-induced behavioural deficits, clozapine reduced LPS-driven inflammatory cytokine production by microglia, indicating that clozapine has the ability to directly reduce inflammation, which may benefit progressive MS patients.
Protective effects provided by either of these compounds could aid in the development of unique combination therapies to target both the inflammatory immune component and the cellular components seen at different stages of MS. MIS416 induced changes to serum cytokines and growth factors in the periphery could be harnessed to treat not just MS but other auto-immune diseases characterised by a similar cytokine profile.
Advisors/Committee Members: La Flamme, Anne, Kivell, Bronwyn.
Subjects/Keywords: Multiple sclerosis; Cuprizone; Clozapine; Myelin
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APA (6th Edition):
Templeton, N. (2017). The effect of clozapine and MIS416 on demyelination, remyelination and immunomodulation in the murine cuprizone model. (Doctoral Dissertation). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/6439
Chicago Manual of Style (16th Edition):
Templeton, Nicola. “The effect of clozapine and MIS416 on demyelination, remyelination and immunomodulation in the murine cuprizone model.” 2017. Doctoral Dissertation, Victoria University of Wellington. Accessed February 26, 2021.
http://hdl.handle.net/10063/6439.
MLA Handbook (7th Edition):
Templeton, Nicola. “The effect of clozapine and MIS416 on demyelination, remyelination and immunomodulation in the murine cuprizone model.” 2017. Web. 26 Feb 2021.
Vancouver:
Templeton N. The effect of clozapine and MIS416 on demyelination, remyelination and immunomodulation in the murine cuprizone model. [Internet] [Doctoral dissertation]. Victoria University of Wellington; 2017. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10063/6439.
Council of Science Editors:
Templeton N. The effect of clozapine and MIS416 on demyelination, remyelination and immunomodulation in the murine cuprizone model. [Doctoral Dissertation]. Victoria University of Wellington; 2017. Available from: http://hdl.handle.net/10063/6439
University of Toronto
19.
Patel, Viral Prakash.
Using Computers to Assess Cognition in MS: Improving Tried and Tested Indices to Capture Real World Challenges.
Degree: 2016, University of Toronto
URL: http://hdl.handle.net/1807/75843
► Cognitive dysfunction is common in people with multiple sclerosis (MS) and causes limitation in activities of daily living. Current cognitive screens are limited by time…
(more)
▼ Cognitive dysfunction is common in people with multiple sclerosis (MS) and causes limitation in activities of daily living. Current cognitive screens are limited by time and cost requirements and they lack ecological validity. The objective of the present study was to develop an improved method of cognitive assessment using real-world distracters. A sample of 102 MS subjects and 69 healthy controls underwent testing with a modified computerized Symbol Digit Modalities Test (c-SDMT) and the Minimal Assessment of Cognitive Functioning in MS battery. Half completed the distracter c-SDMT and half non-distracter. Relative to the traditional SDMT, significantly more MS subjects were impaired on the distracter c-SDMT, but not on the non-distracter test. The distracter test had a sensitivity of 82% and specificity of 80% in detecting global cognitive impairment. The incorporation of distracters improves the sensitivity of the c-SDMT and offers a quick and easy method for detecting cognitive dysfunction.
M.Sc.
Advisors/Committee Members: Feinstein, Anthony, Medical Science.
Subjects/Keywords: Cognition; Multiple Sclerosis; 0317
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APA (6th Edition):
Patel, V. P. (2016). Using Computers to Assess Cognition in MS: Improving Tried and Tested Indices to Capture Real World Challenges. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/75843
Chicago Manual of Style (16th Edition):
Patel, Viral Prakash. “Using Computers to Assess Cognition in MS: Improving Tried and Tested Indices to Capture Real World Challenges.” 2016. Masters Thesis, University of Toronto. Accessed February 26, 2021.
http://hdl.handle.net/1807/75843.
MLA Handbook (7th Edition):
Patel, Viral Prakash. “Using Computers to Assess Cognition in MS: Improving Tried and Tested Indices to Capture Real World Challenges.” 2016. Web. 26 Feb 2021.
Vancouver:
Patel VP. Using Computers to Assess Cognition in MS: Improving Tried and Tested Indices to Capture Real World Challenges. [Internet] [Masters thesis]. University of Toronto; 2016. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/1807/75843.
Council of Science Editors:
Patel VP. Using Computers to Assess Cognition in MS: Improving Tried and Tested Indices to Capture Real World Challenges. [Masters Thesis]. University of Toronto; 2016. Available from: http://hdl.handle.net/1807/75843
University of Toronto
20.
Marriott, James John.
Utility of Lorenz Curves in Examining Physician Prescribing Practices: Example of Ontario Neurologist Prescribing of Multiple Sclerosis Disease-modifying Therapies in 2009.
Degree: 2012, University of Toronto
URL: http://hdl.handle.net/1807/32262
► BACKGROUND: Differences in disease-modifying therapy (DMT) prescribing patterns between different groups of neurologists have not been explored. HYPOTHESIS: MS-specialist neurologists use a broader range of…
(more)
▼ BACKGROUND: Differences in disease-modifying therapy (DMT) prescribing patterns between different groups of neurologists have not been explored. HYPOTHESIS: MS-specialist neurologists use a broader range of DMTs in contrast to generalist neurologists who preferentially prescribe Avonex. METHODS: Ontario neurologist demographic and geographical characteristics were linked to 2009 DMT prescription data. Lorenz curves and Gini coefficients were constructed to examine prescribing patterns; separating neurologist characteristics dichotomously and separating Avonex from the other DMTs. Gini Coefficients were compared using jack-knife statistical techniques to derive 95% confidence intervals. RESULTS: Prescriptions are highly concentrated with 12% of Ontario neurologists prescribing 80% of DMTs. High-volume prescribers show a broader range of DMT use while low-volume prescribers tend to use a particular DMT. CONCLUSIONS: The majority of DMTs are prescribed by a small subset of neurologists. High-volume prescribers show more variability in DMT use while low-volume prescribers tend to individually focus on a narrower range of DMTs.
MAST
Advisors/Committee Members: O'Connor, Paul, Medical Science.
Subjects/Keywords: multiple sclerosis; Lorenz curve; 0564
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APA (6th Edition):
Marriott, J. J. (2012). Utility of Lorenz Curves in Examining Physician Prescribing Practices: Example of Ontario Neurologist Prescribing of Multiple Sclerosis Disease-modifying Therapies in 2009. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/32262
Chicago Manual of Style (16th Edition):
Marriott, James John. “Utility of Lorenz Curves in Examining Physician Prescribing Practices: Example of Ontario Neurologist Prescribing of Multiple Sclerosis Disease-modifying Therapies in 2009.” 2012. Masters Thesis, University of Toronto. Accessed February 26, 2021.
http://hdl.handle.net/1807/32262.
MLA Handbook (7th Edition):
Marriott, James John. “Utility of Lorenz Curves in Examining Physician Prescribing Practices: Example of Ontario Neurologist Prescribing of Multiple Sclerosis Disease-modifying Therapies in 2009.” 2012. Web. 26 Feb 2021.
Vancouver:
Marriott JJ. Utility of Lorenz Curves in Examining Physician Prescribing Practices: Example of Ontario Neurologist Prescribing of Multiple Sclerosis Disease-modifying Therapies in 2009. [Internet] [Masters thesis]. University of Toronto; 2012. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/1807/32262.
Council of Science Editors:
Marriott JJ. Utility of Lorenz Curves in Examining Physician Prescribing Practices: Example of Ontario Neurologist Prescribing of Multiple Sclerosis Disease-modifying Therapies in 2009. [Masters Thesis]. University of Toronto; 2012. Available from: http://hdl.handle.net/1807/32262
Victoria University of Wellington
21.
O'Sullivan, David.
Using Experimental
Autoimmune Encephalomyelitis to Identify Prospective Treatments for Multiple Sclerosis.
Degree: 2012, Victoria University of Wellington
URL: http://hdl.handle.net/10063/2126
► Multiple sclerosis (MS) is an inflammatory disease, mediated by immune cells attacking the myelin sheaths that surround nerve axons. The autoimmune nature of this disease…
(more)
▼ Multiple sclerosis (MS) is an inflammatory disease, mediated by immune cells attacking the myelin sheaths that surround nerve axons. The autoimmune nature of this disease combined with heterogeneity in disease presentation and pathology makes MS a difficult disease to treat. Although some treatment options are currently available, there is strong demand for more effective treatment alternatives. Therefore, this thesis utilises an animal model of MS, experimental autoimmune encephalomyelitis (EAE), to identify new treatment strategies for MS. These studies encompass three separate lines of inquiry with the primarily focus on investigating the use and mechanisms of action by which microtubule-stabilising drugs (MSDs) modify EAE expression. Two other distinct and novel immunotherapies were also explored: the anti-psychotic drug, risperidone, and the Toll like receptor-9 and nucleotide oligomerization domain-containing protein 2 (TLR-9/NOD2) agonist, MIS416.
MSDs are a class of anti-proliferative compounds, which can delay EAE disease onset and reduce disease burden. Administration of the MSD, paclitaxel, directly after EAE immunisation resulted in complete inhibition of antigen-specific encephalogenic responses within the spleen and attenuated responses within the lymph nodes. In contrast, administration of paclitaxel at a later time point did not alter antigen-specific responses, but inhibited immune cell infiltration into the central nervous system (CNS). Using in vivo proliferation and migration assays it was demonstrated that paclitaxel inhibited both immune cell proliferation and migration; indicating these two factors are likely to contribute to the disease modifying effects of MSDs. Futhermore, the combined administration of two MSDs, peloruside A and ixabepilone, resulted in synergistic disease suppression in vivo while the combination of paclitaxel and a currently used MS therapeutic, glatiramer acetate, also exhibited synergistic EAE suppression.
Risperidone is an atypical antipsychotic used to treat schizophrenia, however there is evidence that risperidone can also modulate the immune system. The current study
demonstrated that risperidone reduced EAE disease severity and induced an increase in splenic CD4⁺ T cells and antigen-specific IFN-γ production. Additionally, as macrophages have a crucial role in EAE disease development, the effect of risperidone on macrophage activation was explored. In cultured macrophages risperidone induced a reduction in IL-12 production and CD40 expression while increasing IL-10 production. These findings suggest that regulation of macrophage activation may contribute to the reduction in EAE.
MIS416 is a novel microparticle that stimulates TLR9 and NOD2 receptors. A phase 2A trial is currently underway to evaluate the effects of MIS416 in progressive MS patients, yet the mechanisms by which MIS416 alters the immune system are not completely understood. The current study found that MIS416 effectively but transiently reduces EAE and that IFN-γ is necessary for this disease…
Advisors/Committee Members: La Flamme, Anne, Miller, John.
Subjects/Keywords: Autoimmunity; Multiple sclerosis; MS; Immunology
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APA (6th Edition):
O'Sullivan, D. (2012). Using Experimental
Autoimmune Encephalomyelitis to Identify Prospective Treatments for Multiple Sclerosis. (Doctoral Dissertation). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/2126
Chicago Manual of Style (16th Edition):
O'Sullivan, David. “Using Experimental
Autoimmune Encephalomyelitis to Identify Prospective Treatments for Multiple Sclerosis.” 2012. Doctoral Dissertation, Victoria University of Wellington. Accessed February 26, 2021.
http://hdl.handle.net/10063/2126.
MLA Handbook (7th Edition):
O'Sullivan, David. “Using Experimental
Autoimmune Encephalomyelitis to Identify Prospective Treatments for Multiple Sclerosis.” 2012. Web. 26 Feb 2021.
Vancouver:
O'Sullivan D. Using Experimental
Autoimmune Encephalomyelitis to Identify Prospective Treatments for Multiple Sclerosis. [Internet] [Doctoral dissertation]. Victoria University of Wellington; 2012. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10063/2126.
Council of Science Editors:
O'Sullivan D. Using Experimental
Autoimmune Encephalomyelitis to Identify Prospective Treatments for Multiple Sclerosis. [Doctoral Dissertation]. Victoria University of Wellington; 2012. Available from: http://hdl.handle.net/10063/2126
22.
White, Madeleine P. J.
Innate immunomodulation with MIS416: mechanism of action in experimental autoimmune encephalomyelitis.
Degree: 2015, Victoria University of Wellington
URL: http://hdl.handle.net/10063/4655
► Multiple sclerosis (MS) is an immune-mediated disease in which self-reacting T lymphocytes enter the central nervous system (CNS) and direct the damage of the myelin…
(more)
▼ Multiple sclerosis (MS) is an immune-mediated disease in which self-reacting T lymphocytes enter the central nervous system (CNS) and direct the damage of the myelin sheaths, which protect nerve axons. While there is no cure for MS currently, specific disease-modifying therapies are available that target the relapsing-remitting form of MS. However, these therapies are not effective in progressive forms of MS, which affect ~50% of MS patients in New Zealand, and thus there is an urgent need for novel treatments to be developed to treat these patients. MIS416 is a microparticle, which targets phagocytic cells by activating cytosolic receptors NOD2 and Toll-like receptor 9, and has recently completed a phase 2a trial in the treatment of progressive MS with promising results. The aim of this thesis was to elucidate the mechanism(s) by which MIS416 modified autoimmune disease using an animal model of MS, experimental autoimmune encephalomyelitis (EAE).
We determined that weekly intravenous doses of MIS416 were effective at reducing disease in a chronic model of MS, EAE, and we used this dosing regimen to further understand mechanisms involved in MIS416-induced EAE protection. It was found that MIS416 treatment induced a number of peripheral immune changes which had the potential to alter a T cell-mediated autoimmune disease, including increased levels of serum NO and IFN-γ, increased numbers of Tregs and macrophages as well as increased expression of PD-L1, an anti-proliferative ligand. Additionally, we also determined that MIS416 treatment significantly reduced T cell proliferation in vitro and in vivo.
To investigate which of these peripheral changes were involved in MIS416-mediated protection from EAE, we assessed each change individually in our disease model. We found that the central immune-modulating factor responsible for the protective effects of MIS416 treatment was IFN-γ (White, Webster, O'Sullivan, Stone, & La Flamme, 2014) as IFN-γ-/- mice treated with MIS416 were not protected from EAE. This protective role of MIS416-induced IFN-γ was likely to have been mediated through downstream effects given that in the absence of IFN-γ many of these changes were not seen. In particular, the macrophage population did not expand in MIS416-treated IFN-γ-/- mice, and the expression of the immunoregulatory ligand, PD-L1, was not enhanced suggesting that macrophage expressed PD-L1 may be one of the ways in which MIS416-induced IFN-γ altered EAE. While NO was found to contribute to the MIS416-mediated suppression of T cell proliferation ex vivo and IFN-γ-/- mice did not have elevated levels of NO, the in vivo inhibition of iNOS by aminoguanidine did not ablate MIS416 protection suggesting that these pathways were not central to disease protection. Additionally, MIS416 treatment was shown to increase the number and function of Tregs, and in the absence of IFN-γ this expansion was reduced. Altogether, this research indicated that IFN-γ was key to MIS416-mediated protection possibly through an expansion of immunoregulatory…
Advisors/Committee Members: La Flamme, Anne, Webster, Gill.
Subjects/Keywords: Multiple sclerosis; Innate immunology; Autoimmunity
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APA (6th Edition):
White, M. P. J. (2015). Innate immunomodulation with MIS416: mechanism of action in experimental autoimmune encephalomyelitis. (Doctoral Dissertation). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/4655
Chicago Manual of Style (16th Edition):
White, Madeleine P J. “Innate immunomodulation with MIS416: mechanism of action in experimental autoimmune encephalomyelitis.” 2015. Doctoral Dissertation, Victoria University of Wellington. Accessed February 26, 2021.
http://hdl.handle.net/10063/4655.
MLA Handbook (7th Edition):
White, Madeleine P J. “Innate immunomodulation with MIS416: mechanism of action in experimental autoimmune encephalomyelitis.” 2015. Web. 26 Feb 2021.
Vancouver:
White MPJ. Innate immunomodulation with MIS416: mechanism of action in experimental autoimmune encephalomyelitis. [Internet] [Doctoral dissertation]. Victoria University of Wellington; 2015. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10063/4655.
Council of Science Editors:
White MPJ. Innate immunomodulation with MIS416: mechanism of action in experimental autoimmune encephalomyelitis. [Doctoral Dissertation]. Victoria University of Wellington; 2015. Available from: http://hdl.handle.net/10063/4655
23.
Jaouën, Alexandre.
Etablissement d'un protocole haut débit d'acquisition et d'analyse d'images pour les études précliniques par microscopie bi-photonique intravitale multispectrale : application à l'étude de la neuroinflammation provoquée par un modèle murin de sclérose en plaque : Establishment of a high-speed acquisition and image analysis protocol for preclinical studies using intravital and multispectral two-photon microscopy : application to the study of neuroinflammation induced with a mouse model of multiple sclerosis.
Degree: Docteur es, Neurosciences, 2017, Aix Marseille Université
URL: http://www.theses.fr/2017AIXM0619
► La sclérose en plaques est une maladie chronique, auto-immune et neurodégénérative qui se traduit par l’apparition de plaques inflammatoires démyélinisantes dans le système nerveux central.…
(more)
▼ La sclérose en plaques est une maladie chronique, auto-immune et neurodégénérative qui se traduit par l’apparition de plaques inflammatoires démyélinisantes dans le système nerveux central. Pour caractériser la réponse immunitaire innée, j’ai développé des outils d’imagerie optique non linéaire multispectrale intravitale, et des solutions semi automatisées d’analyse d’images. J’ai participé à la mise au point d’un protocole d’identification des phénotypes immunitaires en cytométrie. Ces outils appliqués à l’étude de l’encéphalomyélite auto-immune expérimentale, un modèle murin de SEP, ont permis d’analyser la cascade immunitaire par immunomarquages et marquages fluorescents transgéniques, de décrire les distributions des populations cellulaires dans le SNC, et de les associer à la dégradation axonale sur des échelles de temps de la seconde à la semaine. Sur une lignée de souris transgénique, Thy1-CFP/Cd11c-EYFP/LysM-EGFP, j’ai suivi en microscopie biphotonique l’évolution des densités de cellules fluorescentes dans la moelle épinière pendant plusieurs semaines. J’ai conclu que la dégénération axonale et les déficits moteurs sont corrélés avec l’infiltration par les méninges de neutrophiles et monocytes. Les monocytes se différencient in situ en cellules dendritiques d’origine monocytaire (moDCs) parallèlement à l'activation de la microglie. Ces événements cellulaires, dont la maturation des moDCs sont corrélés avec la résorption de l’inflammation. La méthodologie est en place pour poursuivre ces investigations sur d’autres modèles. L’optimisation du microscope m’a aussi permis d’accéder simultanément au contraste endogène CARS pour visualiser la gaine de myéline.
Multiple sclerosis is a chronic auto-immune neurodegenerative disease characterized by the appearance of inflammatory plaques in the central nervous system. To characterize the innate immune response I have developed nonlinear optical tools for intravital multispectral imaging as well as semi-automated image processing solutions. I also contributed to the development of a flow cytometry protocol allowing the identification of immune cell phenotypes. Applied to study of Experimental Autoimmune Encephalomyelitis, a mouse model of MS, these tools have allowed to analyze the immune cascade thanks to immunolabelings and transgenic expression of fluorescence, describe the distributions of cell populations in the CNS with regard to neuron degeneration on time scales ranging from seconds to weeks. On a transgenic mouse line Thy1-CFP/Cd11c-EYFP/LysM-EGFP, I have followed by two-photon microscopy the evolution of fluorescent cells densities in the same area of the spinal cord for several weeks. I conclude that axonal degeneration and motor deficits are correlated with neutrophils and monocytes infiltration from the meninges. The monocytes differentiate in situ in monocyte-derived dendritic cells (moDCs) along with the recruitment of activated microglia. These cellular events correlated with a stabilization/remission phase of the disease. MoDCS maturation thus seems…
Advisors/Committee Members: Debarbieux, Franck (thesis director).
Subjects/Keywords: Slérose en plaques; Multiple sclerosis
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APA (6th Edition):
Jaouën, A. (2017). Etablissement d'un protocole haut débit d'acquisition et d'analyse d'images pour les études précliniques par microscopie bi-photonique intravitale multispectrale : application à l'étude de la neuroinflammation provoquée par un modèle murin de sclérose en plaque : Establishment of a high-speed acquisition and image analysis protocol for preclinical studies using intravital and multispectral two-photon microscopy : application to the study of neuroinflammation induced with a mouse model of multiple sclerosis. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2017AIXM0619
Chicago Manual of Style (16th Edition):
Jaouën, Alexandre. “Etablissement d'un protocole haut débit d'acquisition et d'analyse d'images pour les études précliniques par microscopie bi-photonique intravitale multispectrale : application à l'étude de la neuroinflammation provoquée par un modèle murin de sclérose en plaque : Establishment of a high-speed acquisition and image analysis protocol for preclinical studies using intravital and multispectral two-photon microscopy : application to the study of neuroinflammation induced with a mouse model of multiple sclerosis.” 2017. Doctoral Dissertation, Aix Marseille Université. Accessed February 26, 2021.
http://www.theses.fr/2017AIXM0619.
MLA Handbook (7th Edition):
Jaouën, Alexandre. “Etablissement d'un protocole haut débit d'acquisition et d'analyse d'images pour les études précliniques par microscopie bi-photonique intravitale multispectrale : application à l'étude de la neuroinflammation provoquée par un modèle murin de sclérose en plaque : Establishment of a high-speed acquisition and image analysis protocol for preclinical studies using intravital and multispectral two-photon microscopy : application to the study of neuroinflammation induced with a mouse model of multiple sclerosis.” 2017. Web. 26 Feb 2021.
Vancouver:
Jaouën A. Etablissement d'un protocole haut débit d'acquisition et d'analyse d'images pour les études précliniques par microscopie bi-photonique intravitale multispectrale : application à l'étude de la neuroinflammation provoquée par un modèle murin de sclérose en plaque : Establishment of a high-speed acquisition and image analysis protocol for preclinical studies using intravital and multispectral two-photon microscopy : application to the study of neuroinflammation induced with a mouse model of multiple sclerosis. [Internet] [Doctoral dissertation]. Aix Marseille Université 2017. [cited 2021 Feb 26].
Available from: http://www.theses.fr/2017AIXM0619.
Council of Science Editors:
Jaouën A. Etablissement d'un protocole haut débit d'acquisition et d'analyse d'images pour les études précliniques par microscopie bi-photonique intravitale multispectrale : application à l'étude de la neuroinflammation provoquée par un modèle murin de sclérose en plaque : Establishment of a high-speed acquisition and image analysis protocol for preclinical studies using intravital and multispectral two-photon microscopy : application to the study of neuroinflammation induced with a mouse model of multiple sclerosis. [Doctoral Dissertation]. Aix Marseille Université 2017. Available from: http://www.theses.fr/2017AIXM0619
University of Texas Southwestern Medical Center
24.
Riggs, Amanda Lynn.
A Proposed Battery Used to Monitor Treatment Outcomes in Individuals with Multiple Sclerosis: A Case Study.
Degree: 2013, University of Texas Southwestern Medical Center
URL: http://hdl.handle.net/2152.5/1309
► BACKGROUND: Multiple Sclerosis (MS) is a chronic disease of the central nervous system. As of now, there is no cure for MS, but different forms…
(more)
▼ BACKGROUND:
Multiple Sclerosis (MS) is a chronic disease of the central nervous system. As of now, there is no cure for MS, but different forms of treatment have been studied to ameliorate both physical and psychosocial symptoms. Numerous measures have been used within the MS population to monitor symptoms before, during, and after treatment. The aim of this present study was to ensure the usefulness of a battery of outcome measures that will assess MS-related symptoms before and after standard treatment. Another aim of the study was to assess treatment outcomes and determine the current success of each individualized treatment plan.
SUBJECTS: All participants had a confirmed diagnosis of MS, were able to read and write in English, were 18 years of age and older, and able to walk, even briefly, with or without an assistive device. Participants were recruited through The University of Texas Southwestern Medical Center,
Multiple Sclerosis Clinic.
METHOD: Ten qualified MS patients were given a Six-minute walk test, two cognitive tests, and nine psychosocial measures as a baseline assessment. After six to eight weeks of Standard care, all participants were asked to return in order to complete all the measures again. It was hypothesized that the proposed battery of measures would prove to be useful in monitoring treatment outcomes in patients with MS. It was also hypothesized that individualized treatment would prove to be beneficial to each participant over the course of the study.
RESULTS: This study did not provide any evidence that the individualized treatment was beneficial. Moreover, it did not provide any evidence that this particular battery was sensitive enough to truly monitor treatment outcomes. There was only one significant difference found between initial and follow-up assessment. The sum of ranks for the BORG was 0.00 (Z = -2.00, p = .046, r = -0.89) when comparing breathlessness scores. This indicates that individuals that returned for follow-up assessment experienced less breathlessness at follow-up assessment before and after the Six-minute Walk Test than before and after the Six-minute Walk test upon initial assessment.
DISCUSSION: The period between assessments may not have been long enough to identify any changes in treatment or treatment outcomes. Due to the unpredictable nature of MS, it may be important for providers to assess individuals using a comprehensive, biopsychosocial battery on a case-by-case basis rather than a generalized pre-established time frame.
Advisors/Committee Members: Gatchel, Robert J., Chiu, Chung-Yi, Haggard, Robbie.
Subjects/Keywords: Multiple Sclerosis; Treatment Outcome
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MLA ·
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APA (6th Edition):
Riggs, A. L. (2013). A Proposed Battery Used to Monitor Treatment Outcomes in Individuals with Multiple Sclerosis: A Case Study. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/1309
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Riggs, Amanda Lynn. “A Proposed Battery Used to Monitor Treatment Outcomes in Individuals with Multiple Sclerosis: A Case Study.” 2013. Thesis, University of Texas Southwestern Medical Center. Accessed February 26, 2021.
http://hdl.handle.net/2152.5/1309.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Riggs, Amanda Lynn. “A Proposed Battery Used to Monitor Treatment Outcomes in Individuals with Multiple Sclerosis: A Case Study.” 2013. Web. 26 Feb 2021.
Vancouver:
Riggs AL. A Proposed Battery Used to Monitor Treatment Outcomes in Individuals with Multiple Sclerosis: A Case Study. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2013. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/2152.5/1309.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Riggs AL. A Proposed Battery Used to Monitor Treatment Outcomes in Individuals with Multiple Sclerosis: A Case Study. [Thesis]. University of Texas Southwestern Medical Center; 2013. Available from: http://hdl.handle.net/2152.5/1309
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Otago
25.
Boland, Pauline.
Coping and Multiple Sclerosis:Individuals with Multiple Sclerosis and their Significant Others
.
Degree: 2011, University of Otago
URL: http://hdl.handle.net/10523/1758
► Multiple Sclerosis (MS) is a degenerative condition which affects everyone differently as regards emergence of symptoms. The illness uncertainty associated with MS has ramifications for…
(more)
▼ Multiple Sclerosis (MS) is a degenerative condition which affects everyone differently as regards emergence of symptoms. The illness uncertainty associated with MS has ramifications for how those with the condition and those close to them cope with the illness, with each other and with the effect it has on their lives. Health professionals acknowledge that those with MS need to be seen in the context of their families. The perspective of significant others (SOs) need to be acknowledged. However there is a lack of knowledge about what to expect about how people cope as a dyad.
This study used Interpretative Phenomenological Analysis (IPA) to explore how those with MS and their SOs cope with this illness in their lives. Seven couples were recruited using purposive sampling through the MS society. Each person in the couple was interviewed separately using a semi-structured interview schedule. The interviews were transcribed and analysed using the principles of IPA to produce overarching themes and sub themes. Peer coding by two supervisors helped to enrich the analysis and contributed to the trustworthiness of the findings.
Three overarching themes emerged from the data, two overarching themes with four sub themes and one overarching theme with 3 sub themes. These overarching themes are labelled: Resources and Barriers to Coping, Coping Together: "Peaks and Troughs" and Coping over the Long Haul. Two integrative themes emerged, which were called Faith in Self and Faith in Each Other, encapsulating the participants’ identified primary resources which enabled them to cope.
The results of this study will assist health professionals to better comprehend how those with MS cope in an interconnected way with those with whom they share their lives. This research has highlighted the individual preferences about coping style and choice of coping strategies from the perspective of both the person with MS and their significant other. In addition, the nature of the relationship between couples, and the impact this relationship has on their ability to cope, needs to be understood and acknowledged by health professionals. The results of this study indicated that the relationship can be a powerful resource for couples during times of illness related stress. This study adds to the small but growing body of literature about how couples with MS make sense of the disease and how they develop coping strategies relevant to their relationship.
Advisors/Committee Members: Levack, William (advisor).
Subjects/Keywords: Coping;
Multiple Sclerosis;
Dyad
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APA (6th Edition):
Boland, P. (2011). Coping and Multiple Sclerosis:Individuals with Multiple Sclerosis and their Significant Others
. (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/1758
Chicago Manual of Style (16th Edition):
Boland, Pauline. “Coping and Multiple Sclerosis:Individuals with Multiple Sclerosis and their Significant Others
.” 2011. Masters Thesis, University of Otago. Accessed February 26, 2021.
http://hdl.handle.net/10523/1758.
MLA Handbook (7th Edition):
Boland, Pauline. “Coping and Multiple Sclerosis:Individuals with Multiple Sclerosis and their Significant Others
.” 2011. Web. 26 Feb 2021.
Vancouver:
Boland P. Coping and Multiple Sclerosis:Individuals with Multiple Sclerosis and their Significant Others
. [Internet] [Masters thesis]. University of Otago; 2011. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10523/1758.
Council of Science Editors:
Boland P. Coping and Multiple Sclerosis:Individuals with Multiple Sclerosis and their Significant Others
. [Masters Thesis]. University of Otago; 2011. Available from: http://hdl.handle.net/10523/1758
26.
Berard, Jason.
Assessing Cognitive Fatigue in Multiple Sclerosis: A Multidimensional Approach
.
Degree: 2019, University of Ottawa
URL: http://hdl.handle.net/10393/38686
► Cognitive fatigue (CF) presents a considerable challenge for individuals with multiple sclerosis (MS) often negatively impacting quality of life. CF can be defined as a…
(more)
▼ Cognitive fatigue (CF) presents a considerable challenge for individuals with multiple
sclerosis (MS) often negatively impacting quality of life. CF can be defined as a decrease in, or inability to sustain, optimal task performance throughout the duration of a continuous cognitive task. The following dissertation presents three original research reports which evaluate CF in MS in three distinct ways using a multidimensional approach. The objective of this dissertation was to comprehensively evaluate and quantify this frequently misunderstood symptom of the disease. The first report examines four theoretical models of CF in MS which evaluate the interrelatedness of disease severity, fatigue, depression, and sleep quality in order to determine their predictive roles with regard to CF. The second report assesses CF longitudinally by examining whether or not the ability to perform optimally on a continuous cognitive task changes as the disease progresses across a three-year time interval. The final report objectively quantifies CF in MS by evaluating changes in global and regional cerebral blood flow during a task of sustained attention using arterial spin labeling perfusion fMRI. Results of all three reports are further discussed in terms of clinical and research implications. CF is a symptom of MS not readily apparent to outside observers but presents a very real burden for people with the disease that negatively impacts their ability to lead active and productive lives. These individuals may be discriminated against because CF has thus far been a largely unverifiable subjective experience. The totality of these three studies allows for a multidimensional quantification of CF. By providing objective support to the self-reports of individuals with MS, not only can they achieve much needed validation, but this can also lead to interventions that may provide further direct benefit to their health-related quality of life.
Subjects/Keywords: Multiple sclerosis;
Neuropsychology;
Fatigue;
fMRI
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Berard, J. (2019). Assessing Cognitive Fatigue in Multiple Sclerosis: A Multidimensional Approach
. (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/38686
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Berard, Jason. “Assessing Cognitive Fatigue in Multiple Sclerosis: A Multidimensional Approach
.” 2019. Thesis, University of Ottawa. Accessed February 26, 2021.
http://hdl.handle.net/10393/38686.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Berard, Jason. “Assessing Cognitive Fatigue in Multiple Sclerosis: A Multidimensional Approach
.” 2019. Web. 26 Feb 2021.
Vancouver:
Berard J. Assessing Cognitive Fatigue in Multiple Sclerosis: A Multidimensional Approach
. [Internet] [Thesis]. University of Ottawa; 2019. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10393/38686.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Berard J. Assessing Cognitive Fatigue in Multiple Sclerosis: A Multidimensional Approach
. [Thesis]. University of Ottawa; 2019. Available from: http://hdl.handle.net/10393/38686
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Cambridge
27.
Falk, Irene.
Characterization of TSPO expression and radioligand-binding in the central nervous system and peripheral blood in neuroinflammatory disease.
Degree: PhD, 2020, University of Cambridge
URL: https://www.repository.cam.ac.uk/handle/1810/303154
► Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) that is a leading non-traumatic cause of disability in young adults.…
(more)
▼ Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) that is a leading non-traumatic cause of disability in young adults. The 18 kDa Translocator Protein (TSPO) is a mitochondrial protein and positron emission tomography (PET)-imaging target that is highly upregulated in MS brain lesions and may potentially represent both an inflammatory biomarker and a therapeutic target for the monitoring and treatment of MS. However, its pathological significance is not well understood. While experimental autoimmune encephalomyelitis (EAE) in the common marmoset is a well-established primate model of MS, TSPO expression in this model has not yet been studied. Moreover, the comparison of TSPO expression and PET radioligand signal in inflammatory conditions has been limited by the lack of suitable unfixed pathological samples for concurrent measurement of protein expression and radioligand-binding.
In this thesis, I seek to characterize patterns of TSPO expression in fixed CNS tissues from EAE marmosets using multiplex immunofluorescence and directly compare TSPO protein expression measured by flow cytometry with radioligand-binding signal in the peripheral blood of healthy donors and MS patients. Through these studies, I have established that marmoset EAE recapitulates temporal and cellular patterns of TSPO expression seen in MS, rendering it a suitable model for the study of human disease that may give insight into the pathological significance of TSPO in immune dysregulation. Furthermore, I have found TSPO expression in the peripheral blood of MS patients to be significantly increased, suggesting TSPO to be a useful peripheral biomarker of CNS disease. However, I found that radioligand-binding by second-generation PET radioligand PBR28 is paradoxically decreased in the peripheral blood of MS patients, implying that the clinical utility of PBR28 may be limited, likely by conformational changes occurring in inflammation. Collectively, these results allow us to better interpret the pathological significance of TSPO expression and TSPO-radioligand binding in the CNS and peripheral blood in neuroinflammatory disease.
Subjects/Keywords: multiple sclerosis; TSPO; EAE
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Falk, I. (2020). Characterization of TSPO expression and radioligand-binding in the central nervous system and peripheral blood in neuroinflammatory disease. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/303154
Chicago Manual of Style (16th Edition):
Falk, Irene. “Characterization of TSPO expression and radioligand-binding in the central nervous system and peripheral blood in neuroinflammatory disease.” 2020. Doctoral Dissertation, University of Cambridge. Accessed February 26, 2021.
https://www.repository.cam.ac.uk/handle/1810/303154.
MLA Handbook (7th Edition):
Falk, Irene. “Characterization of TSPO expression and radioligand-binding in the central nervous system and peripheral blood in neuroinflammatory disease.” 2020. Web. 26 Feb 2021.
Vancouver:
Falk I. Characterization of TSPO expression and radioligand-binding in the central nervous system and peripheral blood in neuroinflammatory disease. [Internet] [Doctoral dissertation]. University of Cambridge; 2020. [cited 2021 Feb 26].
Available from: https://www.repository.cam.ac.uk/handle/1810/303154.
Council of Science Editors:
Falk I. Characterization of TSPO expression and radioligand-binding in the central nervous system and peripheral blood in neuroinflammatory disease. [Doctoral Dissertation]. University of Cambridge; 2020. Available from: https://www.repository.cam.ac.uk/handle/1810/303154
University of Ottawa
28.
Venasse, Myriam.
Understanding the Impact of Disability on Dietary Intake and Patterns in People with Multiple Sclerosis
.
Degree: 2019, University of Ottawa
URL: http://hdl.handle.net/10393/39782
► As current treatments for multiple sclerosis (MS) do not prevent the accumulation of long-term disability, researchers and persons with MS are interested in wellness behaviours…
(more)
▼ As current treatments for multiple sclerosis (MS) do not prevent the accumulation of long-term disability, researchers and persons with MS are interested in wellness behaviours and how they may be used to manage MS. This thesis includes a review of the literature on wellness-based interventions in persons with progressive MS. Following this review, a cross-sectional study was conducted to characterize dietary intake by disability status in this population, and to examine the functional and symptomatic correlates of dietary behaviours. Participants with MS and matched controls completed questionnaires and a three-day food intake record. There were significant differences in dietary intake with and without supplements between the MS and control groups. Correlates of dietary behaviours were also examined. Further research examining dietary intake in MS is necessary to understand how disability and other factors impact dietary intake behaviours, and which other correlates may be useful targets for future nutrition interventions.
Subjects/Keywords: Multiple sclerosis;
Diet;
Disability
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APA ·
Chicago ·
MLA ·
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CSE |
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Manager
APA (6th Edition):
Venasse, M. (2019). Understanding the Impact of Disability on Dietary Intake and Patterns in People with Multiple Sclerosis
. (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/39782
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Venasse, Myriam. “Understanding the Impact of Disability on Dietary Intake and Patterns in People with Multiple Sclerosis
.” 2019. Thesis, University of Ottawa. Accessed February 26, 2021.
http://hdl.handle.net/10393/39782.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Venasse, Myriam. “Understanding the Impact of Disability on Dietary Intake and Patterns in People with Multiple Sclerosis
.” 2019. Web. 26 Feb 2021.
Vancouver:
Venasse M. Understanding the Impact of Disability on Dietary Intake and Patterns in People with Multiple Sclerosis
. [Internet] [Thesis]. University of Ottawa; 2019. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10393/39782.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Venasse M. Understanding the Impact of Disability on Dietary Intake and Patterns in People with Multiple Sclerosis
. [Thesis]. University of Ottawa; 2019. Available from: http://hdl.handle.net/10393/39782
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Tasmania
29.
Pittas, Fotini.
Longitudinal study of multiple scherosis in southern Tasmania : description of cohort and impact of demographic, disease, individual and lifestyle factors on clinical multiple sclerosis disability and progression.
Degree: 2009, University of Tasmania
URL: https://eprints.utas.edu.au/21705/1/whole_PittasFotini2009_thesis.pdf
;
https://eprints.utas.edu.au/21705/2/whole_PittasFotini2009Vol2_thesis.pdf
► This thesis presents results of a prevalence survey and longitudinal cohort study (2002 to 2005) of people with clinically definite Multiple Sclerosis (MS) resident in…
(more)
▼ This thesis presents results of a prevalence survey and longitudinal cohort study (2002 to 2005) of people with clinically definite Multiple Sclerosis (MS) resident in Southern Tasmania (62-telephone area code). Case ascertainment was from multiple sources. In the longitudinal study, exposures included demographic (eg gender), disease (e.g. MS course), individual (e.g. BMI) and lifestyle (e.g. smoking) characteristics. Clinical outcome measures included the Expanded Disability Status Scale, Multiple Sclerosis Severity Score, Scripps Neurological Rating Scale and Multiple Sclerosis Functional Composite. Participants were reviewed face-to-face at baseline and 6 monthly thereafter during winter and summer. Questionnaires were filled and blood samples taken at every review. Clinical outcome measures were assessed at baseline and during subsequent winter reviews. The aim of this report was to identify the prevalence of MS in Southern Tasmania, to assess whether the longitudinal cohort was representative and to determine whether various exposures influenced clinical MS disability. Univariate linear regression and generalised estimator equations (GEE) models were used to examine associations between exposures and clinical outcomes. Adjustment for confounders was conducted for significant associations. On census day (7/08/2001) 256 cases were identified in the study region which had an eligible source population of 223 602, giving a crude prevalence rate of 114.5/100 OOO. In total 198 people (70% of eligible individuals) were recruited to the longitudinal study. Over 90% of participants remained in the study from their initial review to study end. Several novel results were obtained regarding exposure and MS disability. Highest level of education completed at baseline was negatively associated with disability (population average EDSS coefficient -0.57, 95% Cl -1.15 to -0.00, P<0.05, adjusted GEE model) and progression (annual change EDSS coefficient -0.22, 95% Cl -0.37 to -0.06, P<0.05, adjusted GEE model). Overweight participants had faster disease progression over the study period (annual change EDSS coefficient 0.19, 95% Cl 0.02 to 0.35, P<0.05, adjusted GEE model). Level of smoking during the study period was positively associated with disease progression. Participants born in summer progressed more than those born in other seasons with level of in utero UVR exposure during the third trimester negatively associated with MS disability. Females who were >13 years old at menarche were less disabled and had slower disease progression. In conclusion, this thesis demonstrates that the prevalence of MS in Southern Tasmania has increased, that several modifiable factors hasten MS progression and that exposures in early life may impact on MS progression.
Subjects/Keywords: Multiple sclerosis
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APA ·
Chicago ·
MLA ·
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CSE |
Export
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Manager
APA (6th Edition):
Pittas, F. (2009). Longitudinal study of multiple scherosis in southern Tasmania : description of cohort and impact of demographic, disease, individual and lifestyle factors on clinical multiple sclerosis disability and progression. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/21705/1/whole_PittasFotini2009_thesis.pdf ; https://eprints.utas.edu.au/21705/2/whole_PittasFotini2009Vol2_thesis.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Pittas, Fotini. “Longitudinal study of multiple scherosis in southern Tasmania : description of cohort and impact of demographic, disease, individual and lifestyle factors on clinical multiple sclerosis disability and progression.” 2009. Thesis, University of Tasmania. Accessed February 26, 2021.
https://eprints.utas.edu.au/21705/1/whole_PittasFotini2009_thesis.pdf ; https://eprints.utas.edu.au/21705/2/whole_PittasFotini2009Vol2_thesis.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Pittas, Fotini. “Longitudinal study of multiple scherosis in southern Tasmania : description of cohort and impact of demographic, disease, individual and lifestyle factors on clinical multiple sclerosis disability and progression.” 2009. Web. 26 Feb 2021.
Vancouver:
Pittas F. Longitudinal study of multiple scherosis in southern Tasmania : description of cohort and impact of demographic, disease, individual and lifestyle factors on clinical multiple sclerosis disability and progression. [Internet] [Thesis]. University of Tasmania; 2009. [cited 2021 Feb 26].
Available from: https://eprints.utas.edu.au/21705/1/whole_PittasFotini2009_thesis.pdf ; https://eprints.utas.edu.au/21705/2/whole_PittasFotini2009Vol2_thesis.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Pittas F. Longitudinal study of multiple scherosis in southern Tasmania : description of cohort and impact of demographic, disease, individual and lifestyle factors on clinical multiple sclerosis disability and progression. [Thesis]. University of Tasmania; 2009. Available from: https://eprints.utas.edu.au/21705/1/whole_PittasFotini2009_thesis.pdf ; https://eprints.utas.edu.au/21705/2/whole_PittasFotini2009Vol2_thesis.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Cambridge
30.
Brown, James William Lyle.
Imaging and therapy in multiple sclerosis.
Degree: PhD, 2020, University of Cambridge
URL: https://doi.org/10.17863/CAM.52109
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.805894
► Multiple sclerosis (MS) is a common, debilitating autoimmune disorder of the central nervous system (CNS). The most visible element of MS pathology is white matter…
(more)
▼ Multiple sclerosis (MS) is a common, debilitating autoimmune disorder of the central nervous system (CNS). The most visible element of MS pathology is white matter (WM) lesions. However, extra-lesional abnormalities are recognised and appear most marked at the outer (subpial) brain surfaces at post-mortem. Magnetisation transfer ratio (MTR) is a non-conventional MRI sequence that correlates with myelin density and axonal count, and has recently uncovered reductions in the innermost (periventricular) layers and outermost (cortical) layers of patients with longstanding MS. These abnormalities are termed “outside-in” changes. The cause, extent, evolution and treatment-responsiveness of these outside-in gradients is unknown. Most patients present with relapsing-remitting (RR) MS for which numerous immunomodulatory disease-modifying therapies (DMTs) are licensed. However, after approximately 20 years most convert to secondary progressive (SP) MS where immunomodulatory therapies have little if any effect. Whether DMTs delay or prevent this transition remains unclear. During this PhD I examined whether outside-in MTR gradients occur in different disease stages, their clinical associations and predictive capabilities, and (for periventricular gradients) their response to a potent immunomodulatory DMT. In a separate project, I used real-world data to explore whether DMT use is associated with a lower risk of conversion to SPMS. Outside-in MTR gradients of tissue damage were seen in periventricular and cortical regions at all stages of relapse-onset MS and primary-progressive MS. The periventricular MTR gradient was reversed by peripheral immunomodulation and independently predicted subsequent relapse activity on and off DMTs. The underlying process(es) remain unknown but appear at least partially distinct from those underlying lesion formation; a CSF-mediated process – secondary to meningeal inflammation or primarily degenerative – might explain both periventricular and cortical gradients. Among patients with RRMS, initial treatment with fingolimod, natalizumab or alemtuzumab was associated with a lower risk of conversion to SPMS compared to initial treatment with glatiramer acetate or interferon beta over a median 5.8 years of follow-up. A lower risk of conversion was also associated with early (versus late) commencement of glatiramer acetate or interferon beta; and with early escalation from these therapies to fingolimod, natalizumab or alemtuzumab compared to late escalation. These findings, considered along with these therapies’ risks, may help inform decisions about DMT selection.
Subjects/Keywords: Multiple sclerosis; Imaging; Therapy
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APA (6th Edition):
Brown, J. W. L. (2020). Imaging and therapy in multiple sclerosis. (Doctoral Dissertation). University of Cambridge. Retrieved from https://doi.org/10.17863/CAM.52109 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.805894
Chicago Manual of Style (16th Edition):
Brown, James William Lyle. “Imaging and therapy in multiple sclerosis.” 2020. Doctoral Dissertation, University of Cambridge. Accessed February 26, 2021.
https://doi.org/10.17863/CAM.52109 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.805894.
MLA Handbook (7th Edition):
Brown, James William Lyle. “Imaging and therapy in multiple sclerosis.” 2020. Web. 26 Feb 2021.
Vancouver:
Brown JWL. Imaging and therapy in multiple sclerosis. [Internet] [Doctoral dissertation]. University of Cambridge; 2020. [cited 2021 Feb 26].
Available from: https://doi.org/10.17863/CAM.52109 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.805894.
Council of Science Editors:
Brown JWL. Imaging and therapy in multiple sclerosis. [Doctoral Dissertation]. University of Cambridge; 2020. Available from: https://doi.org/10.17863/CAM.52109 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.805894
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