subject:(Multidomain)

Carnegie Mellon University

1. Stolzer, Maureen. Phylogenetic Inference for Multidomain Proteins.

Degree: 2011, Carnegie Mellon University

URL: http://repository.cmu.edu/dissertations/47

► In this thesis, I present a model of multidomain evolution with associated algorithms and software for phylogenetic analysis of multidomain families, as well as applications… (more)

▼ In this thesis, I present a model of multidomain evolution with associated algorithms and software for phylogenetic analysis of multidomain families, as well as applications of this novel methodology to case-studies and the human genome. Phylogenetic analysis is of central importance to understanding the origins and evolution of life on earth. In biomedical research, molecular phylogenetics has proved an essential tool for practical applications. Current molecular phylogenetic methods are not equipped, however, to model many of the unique characteristics of multidomain families. Genes that encode this large and important class of proteins are characterized by a mosaic of sequence fragments that encode structural or functional modules, called domains. Multidomain families evolve via domain shuffling, a process that includes insertion, internal duplication, and deletion of domains. This versatile evolutionary mechanism played a transformative role in major evolutionary transitions, including the emergence of multicellular animals and the vertebrate immune system. Multidomain families are ill-suited to current methods for phylogeny reconstruction due to their mosaic composition. Different regions of the same protein may have different evolutionary histories. Moreover, a protein may contain domains that also occur in otherwise unrelated proteins. These attributes pose substantial obstacles for phylogenetic methods that require a multiple sequence alignment as input. In addition, current methods do not incorporate a model of domain shuffling and hence, cannot infer the events that occurred in the history of the family. I address this problem by treating a multidomain family as a set of co-evolving domains, each with its own history. If the family is evolving by vertical descent from a conserved set of ancestral domains, then all constituent domains will have the same phylogenetic history. Disagreement between domain tree topologies is evidence that the family evolved through processes other than speciation and gene duplication. My algorithms exploit this information to reconstruct the history of domain shuffling in the family, as well as the timing of these events and the ancestral domain composition. I have implemented these algorithms in software that outputs the most parsimonious history of events for each domain family. The software also reconstructs a composite family history, including duplications, insertions and losses of all constituent domains and ancestral domain composition. My approach is capable of more detailed and accurate reconstructions than the widely used domain architecture model, which ignores sequence variation between domain instances. In contrast, my approach is based on an explicit model of events and captures sequence variation between domain instances. I demonstrate the utility of this method through case studies of notch-related proteins, protein tyrosine kinases, and membrane-associated guanylate kinases. I further present a largescale analysis of domain shuffling processes through comparison…

Subjects/Keywords: phylogenetics; molecular evolution; multidomain; reconciliation; membrane-associated guanylate kinase (MaGuK)

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APA (6^th Edition):

Stolzer, M. (2011). Phylogenetic Inference for Multidomain Proteins. (Thesis). Carnegie Mellon University. Retrieved from http://repository.cmu.edu/dissertations/47

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Stolzer, Maureen. “Phylogenetic Inference for Multidomain Proteins.” 2011. Thesis, Carnegie Mellon University. Accessed January 22, 2021. http://repository.cmu.edu/dissertations/47.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Stolzer, Maureen. “Phylogenetic Inference for Multidomain Proteins.” 2011. Web. 22 Jan 2021.

Vancouver:

Stolzer M. Phylogenetic Inference for Multidomain Proteins. [Internet] [Thesis]. Carnegie Mellon University; 2011. [cited 2021 Jan 22]. Available from: http://repository.cmu.edu/dissertations/47.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Stolzer M. Phylogenetic Inference for Multidomain Proteins. [Thesis]. Carnegie Mellon University; 2011. Available from: http://repository.cmu.edu/dissertations/47

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Cornell University

2. Escobar-vargas, Jorge. A Spectral Multidomain Penalty Method Solver For Environmental Flow Processes.

Degree: PhD, Civil and Environmental Engineering, 2012, Cornell University

URL: http://hdl.handle.net/1813/31431

► This work presents the details behind each step in the development of a framework for two-dimensional quadrilateral discontinuous Spectral Multidomain Penalty Method (SMPM) solvers for… (more)

▼ This work presents the details behind each step in the development of a framework for two-dimensional quadrilateral discontinuous Spectral Multidomain Penalty Method (SMPM) solvers for environmental flow processes: a shallow water equation (SWE) solver and an incompressible Navier-Stokes equations (NSE) (under the Boussinesq approximation) solver, with additional emphasis given to the associated pressure solver. The potential for environmental flow simulations through spectral methods is very strong since these methods are exponentially accurate, non-dissipative and nondispersive. These characteristics translate into capturing the smallest resolved scales of the flow and the propagation of ocean/lake waves with minimum numerical error. In addition, the element-based capability of the method enables the appropriate resolution of the important scales of the processes being modeled, the localization of specific events, and the treatment of complex boundary conditions and geometries. Finally, the discontinuous character of the method add enhanced stability to the method for highlynonlinear under-resolved simulations, an intrinsic characteristic of environmental flow simulations. In the SWE solver, the SMPM is compared with a nodal discontinuous Galerkin method (DGM), where the equations are solved with an explicit SSP-RK34 method. The comparison is done by applying both methods to a suite of six commonly considered geophysical flow test cases; we also include results for a classical continuous Galerkin (i.e., spectral element) method for comparison. Both the analysis and numerical experiments show that the SMPM and DGM are essentially identical; both methods can be shown to be equivalent for very special choices of quadrature rules and Riemann solvers in the DGM along with special choices in the type of penalty term in the SMPM. In the NSE solver time is discretized with a high-order fractional step projection method, where the non-linear advection and forcing terms are advanced explicitly via a stiffly stable scheme. After that, an implicit solution of a Poisson pressure equation (PPE) is solved in order to introduce the incompressibility constraint. In the final fractional time-step linear viscosity forces are also solved implicitly by means of a modified Helmholtz equation. Stability of the numerical scheme for under-resolved simulations at high Reynolds numbers is ensured through use of penalty techniques, spectral filtering, dealiasing, and strong adaptive interfacial averaging. Special attention is given to the solution of the PPE linear system of equations, where the fundamental building blocks of the PPE solver presented here are a Kronecker (tensor) product-based computation of the left null singular value of the non-symmetric SMPM-discretized Laplacian matrix and a custom-designed two-level preconditioner. Both of these tools are essential towards ensuring existence and uniqueness of the solution of the discrete linear system of equations and enabling its efficient iterative calculation. Accuracy, efficiency,… Advisors/Committee Members: Diamessis, Peter J. (chair), Van Loan, Charles Francis (committee member), Warner, Derek H. (committee member), Pope, Stephen Bailey (committee member).

Subjects/Keywords: Spectral Multidomain method; Incompressible Navier-Stokes equations; Shallow Water equations

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APA (6^th Edition):

Escobar-vargas, J. (2012). A Spectral Multidomain Penalty Method Solver For Environmental Flow Processes. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/31431

Chicago Manual of Style (16^th Edition):

Escobar-vargas, Jorge. “A Spectral Multidomain Penalty Method Solver For Environmental Flow Processes.” 2012. Doctoral Dissertation, Cornell University. Accessed January 22, 2021. http://hdl.handle.net/1813/31431.

MLA Handbook (7^th Edition):

Escobar-vargas, Jorge. “A Spectral Multidomain Penalty Method Solver For Environmental Flow Processes.” 2012. Web. 22 Jan 2021.

Vancouver:

Escobar-vargas J. A Spectral Multidomain Penalty Method Solver For Environmental Flow Processes. [Internet] [Doctoral dissertation]. Cornell University; 2012. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1813/31431.

Council of Science Editors:

Escobar-vargas J. A Spectral Multidomain Penalty Method Solver For Environmental Flow Processes. [Doctoral Dissertation]. Cornell University; 2012. Available from: http://hdl.handle.net/1813/31431

University of Colorado

3. Babb, Tracy. Accelerated Time-Stepping of Parabolic and Hyperbolic Pdes Via Fast Direct Solvers for Elliptic Problems.

Degree: PhD, 2019, University of Colorado

URL: https://scholar.colorado.edu/appm_gradetds/156

► The dissertation concerns numerical methods for approximately solving certain linear partial differential equations. The foundation is a solution methodology for linear elliptic boundary value… (more)

▼ The dissertation concerns numerical methods for approximately solving certain linear partial differential equations. The foundation is a solution methodology for linear elliptic boundary value problems that we call the ``Hierarchical Poincare-Steklov (HPS)'' method. This method is based on a high-order multidomain spectral discretization that is designed to work particularly well in conjunction with nested-dissection type direct solvers. The methods presented apply in any dimension, but their efficiency deteriorates as the dimension increases, and dimensions higher than three are generally not considered. A key competitive advantage of the HPS method is that the linear system that results from discretizing an elliptic PDE is solved using a direct rather than an iterative solver. This solver is closely related to existing nested dissection and multifrontal solvers, and has a similar computational profile that involves a ``build stage'' that is reasonably efficient, and then a ``solve stage'' that is very fast. This makes the method particularly powerful for use in situations where a sequence of linear problems involving the same operator needs to be solved, as happens for instance when solving certain parabolic and hyperbolic PDEs. The use of a direct solver also enables the method to solve many problems that are intractable to iterative solvers, such as Helmholtz problems at intermediate and high frequencies. The HPS methodology was originally published as a solution method for homogeneous elliptic problems, and the core contributions of the dissertation involve the extension of the methodology to more general environments. Specifically, there are four key contributions: 1. An extension of the method to handle non homogeneous elliptic equations that involve forcing terms in the volume of the domain. 2. A generalization of the method to allow the use of refined meshes in order to resolve local singularities. 3. An efficient solver for hyperbolic equations that works by applying the HPS methodology to explicitly build highly accurate approximations to the time evolution operator. This enables the use of very long time steps, and parallel in time implementations. 4. An efficient solver for parabolic problems, where the main idea is to accelerate implicit time-stepping schemes by using the HPS methodology to pre-compute the solution operator involved in the elliptic solve. This work also includes an extension to certain non-linear problems. All techniques presented are analyzed in terms of their complexity. Accuracy and stability are demonstrated via extensive numerical examples. Advisors/Committee Members: Per-Gunnar Martinsson, Daniel Appelo, Adrianna Gillman, Bengt Fornberg, Gregory Beylkin.

Subjects/Keywords: Poincare-steklov; linear partial differential equations; multidomain spectral discretization; Applied Mathematics

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APA (6^th Edition):

Babb, T. (2019). Accelerated Time-Stepping of Parabolic and Hyperbolic Pdes Via Fast Direct Solvers for Elliptic Problems. (Doctoral Dissertation). University of Colorado. Retrieved from https://scholar.colorado.edu/appm_gradetds/156

Chicago Manual of Style (16^th Edition):

Babb, Tracy. “Accelerated Time-Stepping of Parabolic and Hyperbolic Pdes Via Fast Direct Solvers for Elliptic Problems.” 2019. Doctoral Dissertation, University of Colorado. Accessed January 22, 2021. https://scholar.colorado.edu/appm_gradetds/156.

MLA Handbook (7^th Edition):

Babb, Tracy. “Accelerated Time-Stepping of Parabolic and Hyperbolic Pdes Via Fast Direct Solvers for Elliptic Problems.” 2019. Web. 22 Jan 2021.

Vancouver:

Babb T. Accelerated Time-Stepping of Parabolic and Hyperbolic Pdes Via Fast Direct Solvers for Elliptic Problems. [Internet] [Doctoral dissertation]. University of Colorado; 2019. [cited 2021 Jan 22]. Available from: https://scholar.colorado.edu/appm_gradetds/156.

Council of Science Editors:

Babb T. Accelerated Time-Stepping of Parabolic and Hyperbolic Pdes Via Fast Direct Solvers for Elliptic Problems. [Doctoral Dissertation]. University of Colorado; 2019. Available from: https://scholar.colorado.edu/appm_gradetds/156

University of Minnesota

4. Lindquist, Anna K. Dislocations in Magnetite: Experimental Observations of their Structural, Magnetic, and Low-temperature Effects.

Degree: PhD, Geophysics, 2013, University of Minnesota

URL: http://purl.umn.edu/159854

► Magnetite (Fe₃O₄) is the most important mineral to the rock magnetic and paleomagnetic communities and is ubiquitous in igneous, sedimentary, and metamorphic rocks. Larger multidomain… (more)

▼ Magnetite (Fe₃O₄) is the most important mineral to the rock magnetic and paleomagnetic communities and is ubiquitous in igneous, sedimentary, and metamorphic rocks. Larger multidomain (MD) magnetite grains are more common than single domain grains, so understanding how they record paleomagnetic fields would be a boon to paleomagnetists. MD magnetite grains are divided into multiple domains, regions with uniform magnetization, separated by domain walls. Domain walls sweep through magnetite grains easily, so slight changes in ambient magnetic fields can alter the magnetization of MD magnetite. Because of this, MD magnetite is not considered reliable for paleomagnetic studies, and the mechanisms by which MD grains may record past magnetic fields are not well understood. Dislocations, linear crystallographic defects, may increase magnetic coercivity by pinning domain walls in place. This study, for the first time, experimentally investigates this pinning behavior by using a transmission electron microscope (TEM) to simultaneously image magnetic domain walls, dislocations, and low-temperature twin structures. Magnetite grains were deformed in the dislocation glide regime, which is active in natural magnetite grains. Dislocations were not uniformly distributed throughout the sample, but regions with more and longer dislocations pinned domain walls more strongly. First-order reversal curve diagrams demonstrate the presence of regions with pinning strengths of over 125 mT. The strength of domain wall pinning at dislocations was found experimentally and theoretically to be proportional to dislocation length, with longer dislocations pinning more strongly. Average pinning fields were around 0.2 mT. Magnetite grains with more uniformly distributed dislocations would likely have coercivities that were high enough to enable MD magnetite to record geomagnetic fields over geologic timescales. Further, low-temperature TEM and magnetic studies demonstrated that dislocations can affect twin growth in magnetite below the Verwey transition. Deformed magnetite samples had more soft-shouldered Verwey transitions and were able to retain more remanence after low-temperature demagnetization (LTD). Therefore, MD magnetite grains may be able to retain relevant magnetizations, even after LTD. Dislocation length, density, and distribution are then all important considerations when investigating the ways in which MD magnetite may retain a stable record of paleomagnetic field characteristics, even after LTD.

Subjects/Keywords: Geophysics; Dislocation; Domain wall; Magnetite; Multidomain; Transmission electron microscopy; Verwey

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APA (6^th Edition):

Lindquist, A. K. (2013). Dislocations in Magnetite: Experimental Observations of their Structural, Magnetic, and Low-temperature Effects. (Doctoral Dissertation). University of Minnesota. Retrieved from http://purl.umn.edu/159854

Chicago Manual of Style (16^th Edition):

Lindquist, Anna K. “Dislocations in Magnetite: Experimental Observations of their Structural, Magnetic, and Low-temperature Effects.” 2013. Doctoral Dissertation, University of Minnesota. Accessed January 22, 2021. http://purl.umn.edu/159854.

MLA Handbook (7^th Edition):

Lindquist, Anna K. “Dislocations in Magnetite: Experimental Observations of their Structural, Magnetic, and Low-temperature Effects.” 2013. Web. 22 Jan 2021.

Vancouver:

Lindquist AK. Dislocations in Magnetite: Experimental Observations of their Structural, Magnetic, and Low-temperature Effects. [Internet] [Doctoral dissertation]. University of Minnesota; 2013. [cited 2021 Jan 22]. Available from: http://purl.umn.edu/159854.

Council of Science Editors:

Lindquist AK. Dislocations in Magnetite: Experimental Observations of their Structural, Magnetic, and Low-temperature Effects. [Doctoral Dissertation]. University of Minnesota; 2013. Available from: http://purl.umn.edu/159854

5. LI, QING. Multi-domain Protein Unfolding Pathway Studies by Single Molecule Techniques .

Degree: 2017, Duke University

URL: http://hdl.handle.net/10161/14450

► Large multi-domain proteins, which are ubiquitous in the proteomes in eukaryotic and prokaryotic organisms, still lack intensive studies on their folding mechanisms due to… (more)

▼ Large multi-domain proteins, which are ubiquitous in the proteomes in eukaryotic and prokaryotic organisms, still lack intensive studies on their folding mechanisms due to their complicated interactions between and inside of their domains. My work is broadly aimed at characterize folding behaviors and mechanisms of large, multi-domain proteins. In the first part of my thesis work, I developed a novel mechanical folding polypeptide probe based on the anti-parallel coiled-coil domain of a natural protein (Archeal Box C/D sRNP Core Protein) to enable us to capture the progress of the unfolding front along the host protein structure. In this way, the structural origin of the signal from single molecule force spectroscopy (SMFS) based on atomic force microscopy (AFM) can be directly identified. Beyond this published work, I also characterized and compared the unfolding pathway of two homologous multi-domain proteins – yeast phosphoglycerate kinase (PGK) and its E.coli homolog. I found that yeast PGK has much higher mechanical stability than E.coli PGK although previous literature reported that they had similar thermodynamics stability determined by bulk measurements. In collaboration with Mr. Zackary N. Scholl, we characterized another multi-domain protein, protein S, and its two isolated domains (protein S N terminal domain and C terminal domain). By matching the statistical distributions of the unfolding forces from the truncated domains with the distributions of forces from full protein S, we solved the problem of assigning force peaks in the force-extension (FE) curves to individual domains. However, accurate determination of the structural correspondence to the force peaks still needs insertion of CC probes into the loop regions of these multi-domain proteins. In the second part of my thesis work, I focused on integrating our AFM-SMFS with fluorescence microscopy methods. In particular, I have focused on constructing and mounting a home-made AFM force spectrometer on a high magnification inverted microscope to monitor fluorescence signal changes when stretching a single protein molecule. I am also setting up a total internal reflection fluorescence microscope (TIRF) for combination of Förster resonance energy transfer (FRET) and SMFS measurements in the future. In Chapter 1, I will discuss background of multi-protein unfolding, SMFS method principles and coarse-grained (CG) steered molecular dynamics (SMD) simulation. This chapter will focus on the importance of understanding multi-protein unfolding pathway, the advantage of using SMFS as an experimental way of characterizing multi-domain protein unfolding behavior. As a theoretical way to analyze what event happened during the forced unfolding of multi-domain protein, CG-SMD simulations usually support our SMFS results, and providing details for interpreting FE curves obtained in SMFS measurements. In Chapter 2, I present my recently completed work on developing a mechanical force probe based on an anti-parallel coiled-coil polypeptide… Advisors/Committee Members: Marszalek, Piotr (advisor).

Subjects/Keywords: Biophysics; AFM; Coiledcoil; Multidomain protein; PGK; Single molecule force spectroscopy; TPM

10 more images…

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APA (6^th Edition):

LI, Q. (2017). Multi-domain Protein Unfolding Pathway Studies by Single Molecule Techniques . (Thesis). Duke University. Retrieved from http://hdl.handle.net/10161/14450

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

LI, QING. “Multi-domain Protein Unfolding Pathway Studies by Single Molecule Techniques .” 2017. Thesis, Duke University. Accessed January 22, 2021. http://hdl.handle.net/10161/14450.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

LI, QING. “Multi-domain Protein Unfolding Pathway Studies by Single Molecule Techniques .” 2017. Web. 22 Jan 2021.

Vancouver:

LI Q. Multi-domain Protein Unfolding Pathway Studies by Single Molecule Techniques . [Internet] [Thesis]. Duke University; 2017. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10161/14450.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

LI Q. Multi-domain Protein Unfolding Pathway Studies by Single Molecule Techniques . [Thesis]. Duke University; 2017. Available from: http://hdl.handle.net/10161/14450

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Pezzella, Angela M. Constant connection: College students’ smartphones attachment and close relationship attachments across domains.

Degree: 2018, James Madison University

URL: https://commons.lib.jmu.edu/edspec201019/140

► This study aims to conceptualize the way individuals, more notably college students and emerging adults, use their smartphones, applying an attachment framework. Recently, research has… (more)

Subjects/Keywords: attachment; smartphones; multidomain attachment; internet; social media; attachment theory; Counselor Education

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APA (6^th Edition):

Pezzella, A. M. (2018). Constant connection: College students’ smartphones attachment and close relationship attachments across domains. (Masters Thesis). James Madison University. Retrieved from https://commons.lib.jmu.edu/edspec201019/140

Chicago Manual of Style (16^th Edition):

Pezzella, Angela M. “Constant connection: College students’ smartphones attachment and close relationship attachments across domains.” 2018. Masters Thesis, James Madison University. Accessed January 22, 2021. https://commons.lib.jmu.edu/edspec201019/140.

MLA Handbook (7^th Edition):

Pezzella, Angela M. “Constant connection: College students’ smartphones attachment and close relationship attachments across domains.” 2018. Web. 22 Jan 2021.

Vancouver:

Pezzella AM. Constant connection: College students’ smartphones attachment and close relationship attachments across domains. [Internet] [Masters thesis]. James Madison University; 2018. [cited 2021 Jan 22]. Available from: https://commons.lib.jmu.edu/edspec201019/140.

Council of Science Editors:

Pezzella AM. Constant connection: College students’ smartphones attachment and close relationship attachments across domains. [Masters Thesis]. James Madison University; 2018. Available from: https://commons.lib.jmu.edu/edspec201019/140

Rice University

7. Moringo, Nicole Christine. MultiDomain Peptide Hydrogel for Soft Tissue Regeneration.

Degree: PhD, Natural Sciences, 2020, Rice University

URL: http://hdl.handle.net/1911/108403

► MultiDomain Peptides (MDP) have been designed and synthesized to create biomaterials. MDPs are designed to supramolecularly self-assemble into a nanofibrous hydrogel mimicking the native extracellular… (more)

▼ MultiDomain Peptides (MDP) have been designed and synthesized to create biomaterials. MDPs are designed to supramolecularly self-assemble into a nanofibrous hydrogel mimicking the native extracellular matrix. The MDP hydrogel supports cell growth and proliferation in vitro. In vivo the MDP hydrogel elicits a mild inflammatory response resulting in cellular infiltration and vascularization. The goals of this work were to 1) create bioactive MDPs capable of driving biological responses and 2) utilize the MDP hydrogel for soft tissue regeneration. Chapter 1 introduces tissue engineering and explains benefits of utilizing hydrogels for regeneration. Chapter 2 aims to design, synthesize, and characterize bioactive MDP hydrogels. Covalent attachment of growth factor mimics displays bioactive signals creating a scaffold that supports cell growth, proliferation, and differentiation in vitro, in contrast to a non- bioactive MDP. In vivo both MDPs are capable of driving tissue regeneration with undiscernible differences. Thus, the non-bioactive MDP was utilized for the remainder of the thesis. Chapter 3 utilizes the MDP hydrogel to drive tissue regeneration. When applied to full-thickness dermal wounds in diabetic mice, the MDP hydrogel resulted in significantly accelerated wound closure, formation of thick granulation tissue including dense vascularization, innervation, and hair follicle regeneration suggesting the MDP hydrogel could be suitable for treatment of wounds in diabetic patients. Chapter 4 examines the antibacterial of the MDP hydrogel. In vitro the MDP hydrogel inhibits the growth of bacteria; however, however, inhibition of bacterial growth did not occur in infected diabetic wounds. Antibiotics were loaded in the MDP hydrogel to create sustained delivery and increase antibacterial activity. In vitro results revealed potent antibacterial activity; however, bacterial growth was not inhibited in vivo. Chapter 5 investigates the response to the MDP following intramuscular injections. Skeletal muscle regeneration is impeded in volumetric muscle loss due to lack of crucial cells, blood vessels, and nerves. Intramuscular injections of MDP hydrogel are rapidly infiltrated by cells, blood vessels, and neural fascicles suggesting utility of the MDP hydrogel for skeletal muscle regeneration. Lastly, Chapter 6 reiterates the major findings of this work and details future directions and potential for MDP hydrogels as biomaterials for tissue engineering. Advisors/Committee Members: Hartgerink, Jeffrey D (advisor).

Subjects/Keywords: self-assembly peptide; supramolecular chemistry; MultiDomain Peptide; hydrogel; tissue regeneration; wound healing; intramuscular injection

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APA (6^th Edition):

Moringo, N. C. (2020). MultiDomain Peptide Hydrogel for Soft Tissue Regeneration. (Doctoral Dissertation). Rice University. Retrieved from http://hdl.handle.net/1911/108403

Chicago Manual of Style (16^th Edition):

Moringo, Nicole Christine. “MultiDomain Peptide Hydrogel for Soft Tissue Regeneration.” 2020. Doctoral Dissertation, Rice University. Accessed January 22, 2021. http://hdl.handle.net/1911/108403.

MLA Handbook (7^th Edition):

Moringo, Nicole Christine. “MultiDomain Peptide Hydrogel for Soft Tissue Regeneration.” 2020. Web. 22 Jan 2021.

Vancouver:

Moringo NC. MultiDomain Peptide Hydrogel for Soft Tissue Regeneration. [Internet] [Doctoral dissertation]. Rice University; 2020. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1911/108403.

Council of Science Editors:

Moringo NC. MultiDomain Peptide Hydrogel for Soft Tissue Regeneration. [Doctoral Dissertation]. Rice University; 2020. Available from: http://hdl.handle.net/1911/108403

8. Boutigny, François. Multidomain virtual network embedding under security-oriented requirements applied to 5G network slices : Incorporation de réseaux virtuels dans une infrastructure multidomaine sous exigences de sécurité appliquée au slicing réseau en 5G.

Degree: Docteur es, Informatique, données, IA, 2019, Institut polytechnique de Paris

URL: http://www.theses.fr/2019IPPAS002

►

La 5G apporte un nouveau concept, le network slicing (découpage du réseau en tranches). Cette technologie permet de généraliser le modèle économique des MVNO à… (more)

▼

La 5G apporte un nouveau concept, le network slicing (découpage du réseau en tranches). Cette technologie permet de généraliser le modèle économique des MVNO à des entreprises qui ont besoin d’opérer un réseau, sans que cela ne soit leur cœur de métier. Chaque tranche (slice) est un réseau virtuel de bout en bout, dédié et personnalisé, au-dessus d’une infrastructure partagée ; cette infrastructure elle-même être fournie par l’interconnexion de fournisseurs d’infrastructure: nous parlons dans ce cas d’infrastructure multi-domaine.L’objectif de cette thèse est d’étudier l’allocation de ces tranches dans une telle infrastructure multi-domaine. Le problème est connu comme l’incorporation de réseau virtuel (Virtual Network Embedding (VNE)). Il s’agit d’un problème NP-difficile. Pratiquement, le problème VNE recherche à quelles ressources physiques associer un ensemble d’éléments virtuels. Les ressources physiques décrivent ce qu’elles peuvent offrir. Les éléments virtuels décrivent ce qu’ils exigent. La mise en relation de ces offres et de ces demandes est la clé pour résoudre le problème VNE.En l’espèce, nous nous sommes intéressés à la modélisation et à la mise en place d’exigences de sécurité. En effet, nous nous attendons à ce que les acteurs à l’initiative des tranches appartiennent à des sphères éloignées des télécommunications. Or de la même façon qu’ils connaissent peu ce domaine, nous pouvons nous attendre à ce que leurs besoins, notamment de sécurité, s’expriment d’une façon sans précédent dans le contexte des tranches.Cette thèse présente un algorithme capable de traiter des exigences variées selon un modèle extensible fondé sur un solveur de satisfiabilité appliqué à des théories décidables (Satisfiability Modulo Theories (SMT)). Comparée à la programmation linéaire (Integer Linear Programming (ILP)), plus commune dans le domaine des VNE, cette formulation permet d’exprimer les contraintes à satisfaire de façon plus transparente, et d’auditer l’ensemble des contraintes.De plus, ayant conscience que les fournisseurs d’infrastructure sont réticents à exposer les informations relatives à leurs ressources physiques, nous proposons une résolution limitant cette exposition. Ce système a été implémenté et testé avec succès au cours du doctorat.

5G brings a new concept called network slicing. This technology makes it possible to generalize the business model of MVNOs to companies in need to operate a network, without it being their core business. Each slice is an end-to-end, dedicated and customized virtual network, over a shared infrastructure; this infrastructure itself is provided by the interconnection of infrastructure providers: we refer to this case as a multi-domain infrastructure.The objective of this thesis is to study the allocation of these slices in such a multi-domain infrastructure. The problem is known as Virtual Network Embedding (VNE). It is an NP-hard problem. Practically, the VNE problem looks for which physical resources to associate a set of virtual elements. Physical resources describe what…

Advisors/Committee Members: Debar, Hervé (thesis director).

Subjects/Keywords: Réseau virtuel; Multidomaine; 5g; Slice; Sécurité; Smt; Virtual network; Multidomain; 5g; Slice; Security; Smt

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APA (6^th Edition):

Boutigny, F. (2019). Multidomain virtual network embedding under security-oriented requirements applied to 5G network slices : Incorporation de réseaux virtuels dans une infrastructure multidomaine sous exigences de sécurité appliquée au slicing réseau en 5G. (Doctoral Dissertation). Institut polytechnique de Paris. Retrieved from http://www.theses.fr/2019IPPAS002

Chicago Manual of Style (16^th Edition):

Boutigny, François. “Multidomain virtual network embedding under security-oriented requirements applied to 5G network slices : Incorporation de réseaux virtuels dans une infrastructure multidomaine sous exigences de sécurité appliquée au slicing réseau en 5G.” 2019. Doctoral Dissertation, Institut polytechnique de Paris. Accessed January 22, 2021. http://www.theses.fr/2019IPPAS002.

MLA Handbook (7^th Edition):

Boutigny, François. “Multidomain virtual network embedding under security-oriented requirements applied to 5G network slices : Incorporation de réseaux virtuels dans une infrastructure multidomaine sous exigences de sécurité appliquée au slicing réseau en 5G.” 2019. Web. 22 Jan 2021.

Vancouver:

Boutigny F. Multidomain virtual network embedding under security-oriented requirements applied to 5G network slices : Incorporation de réseaux virtuels dans une infrastructure multidomaine sous exigences de sécurité appliquée au slicing réseau en 5G. [Internet] [Doctoral dissertation]. Institut polytechnique de Paris; 2019. [cited 2021 Jan 22]. Available from: http://www.theses.fr/2019IPPAS002.

Council of Science Editors:

Boutigny F. Multidomain virtual network embedding under security-oriented requirements applied to 5G network slices : Incorporation de réseaux virtuels dans une infrastructure multidomaine sous exigences de sécurité appliquée au slicing réseau en 5G. [Doctoral Dissertation]. Institut polytechnique de Paris; 2019. Available from: http://www.theses.fr/2019IPPAS002

9. Queiroz, Eduardo Martinelli Galvão de. Redes ópticas multidomínio: métodos de escolha de nós de borda e algoritmo de roteamento de tráfego.

Degree: PhD, Telecomunicações, 2012, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/18/18155/tde-05102012-091145/ ;

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A crescente demanda de tráfego em redes de acesso pressiona a melhor utilização das redes backbone, que são utilizadas para transporte de grandes taxas de… (more)

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A crescente demanda de tráfego em redes de acesso pressiona a melhor utilização das redes backbone, que são utilizadas para transporte de grandes taxas de dados em diversos domínios (Sistemas Autônomos, SAs). Com o aumento destas redes, aumenta-se a complexidade de topologia das interligações entre domínios. Desta maneira, roteamento de tráfego e pontos de interconexão de SAs (nós de borda) são questões importantes para o desempenho destas redes, que são operadas por diversos provedores que podem utilizar protocolos de comunicação distintos. Neste sentido, o roteamento interdomínio apresenta desafios como a publicação ou não de informações de parâmetros de rede de SAs e como tratar esta questão de maneira globalizada, com novos protocolos e suas especificações. Em termos de pontos de interconexão de SAs, a especificação dos locais onde enlaces inter-redes são conectados aos domínios são importantes para seu desempenho, já que são responsáveis por toda troca de tráfego entre redes distintas. O trabalho considera redes ópticas opacas e translúcidas em cenário multidomínio com bandas multigranulares. Neste cenário é estudado um algoritmo de roteamento multidomínio. No trabalho também é feito um planejamento, especificando em quais nós serão conectados enlaces interdomínio. A principal contribuição deste trabalho é o estudo de planejamento de enlaces interdomínio, com a proposta de um método para escolha de nós de borda (sistematização), com objetivo de diminuir a probabilidade de bloqueio interdomínio. A sistematização é baseada em estudos de resultados de algoritmo genético desenvolvido para o mesmo propósito e sua utilização diminui em até 42% o bloqueio interdomínio. Um algoritmo de alocação de banda também foi desenvolvido para redes multidomínio, que considera parâmetros da camada de rede e óptica para o cálculo de peso de enlaces para encontrar caminhos ópticos entre nós fonte e destino. Os resultados mostram diminuição de até 35% no bloqueio interdomínio com a modificação feita em algoritmo proposto na literatura.

The huge demand for traffic in last mile networks push the better utilization of backbone networks, which are used to transport large data rates in several domains (Autonomous Systems, ASs). With this growth, the topology complexity of interdomain links increases. Then, traffic routing and interconnection points of ASs (border nodes) are relevant questions for the performance of these networks, which are managed by several providers that can use distinct communications protocols. Thus, the interdomain routing presents challenges such as the decision on publishing or not the network´s parameters from ASs and how to deal with this issue in a global way, with new protocols and its specifications. For interconnection points between ASs, the points where interdomain links are connected are important for their performances, since they are responsible for all traffic exchange between distinct networks. This work considers opaque and translucent optical networks in a multidomain scenario with multigranular…

Advisors/Committee Members: César, Amilcar Careli.

Subjects/Keywords: Algoritmo de roteamento multidomínio; Algoritmos genéticos para redes ópticas multidomínio; Border nodes of autonomous systems (AS); Genetic algorithm for multidomain optical networks; Multidomain optical networks; Multidomain routing algorithm; Nós de borda de sistemas autônomos (SA); Redes ópticas multidomínio

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Queiroz, E. M. G. d. (2012). Redes ópticas multidomínio: métodos de escolha de nós de borda e algoritmo de roteamento de tráfego. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/18/18155/tde-05102012-091145/ ;

Chicago Manual of Style (16^th Edition):

Queiroz, Eduardo Martinelli Galvão de. “Redes ópticas multidomínio: métodos de escolha de nós de borda e algoritmo de roteamento de tráfego.” 2012. Doctoral Dissertation, University of São Paulo. Accessed January 22, 2021. http://www.teses.usp.br/teses/disponiveis/18/18155/tde-05102012-091145/ ;.

MLA Handbook (7^th Edition):

Queiroz, Eduardo Martinelli Galvão de. “Redes ópticas multidomínio: métodos de escolha de nós de borda e algoritmo de roteamento de tráfego.” 2012. Web. 22 Jan 2021.

Vancouver:

Queiroz EMGd. Redes ópticas multidomínio: métodos de escolha de nós de borda e algoritmo de roteamento de tráfego. [Internet] [Doctoral dissertation]. University of São Paulo; 2012. [cited 2021 Jan 22]. Available from: http://www.teses.usp.br/teses/disponiveis/18/18155/tde-05102012-091145/ ;.

Council of Science Editors:

Queiroz EMGd. Redes ópticas multidomínio: métodos de escolha de nós de borda e algoritmo de roteamento de tráfego. [Doctoral Dissertation]. University of São Paulo; 2012. Available from: http://www.teses.usp.br/teses/disponiveis/18/18155/tde-05102012-091145/ ;

10. Lazreg, Saïd. Identification inverse d’états multiaxiaux élasto-plastiques par méthode magnétique : Inverse identification of multiaxial elasto-plastic states by magnetic method.

Degree: Docteur es, Mécanique, génie mécanique, génie civil, 2011, Cachan, Ecole normale supérieure

URL: http://www.theses.fr/2011DENS0021

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Cette étude s'intègre dans le cadre d'un développement accru de nouvelles techniques de contrôle non destructif des matériaux magnétiques basées sur les phénomènes de couplage… (more)

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Cette étude s'intègre dans le cadre d'un développement accru de nouvelles techniques de contrôle non destructif des matériaux magnétiques basées sur les phénomènes de couplage magnéto-mécanique. L'objectif est de promouvoir des méthodes originales de mesure des propriétésmagnétiques permettant d'évaluer quantitativement l'état thermo-métallurgico-mécanique d'un matériau par une simple identification inverse.Nous proposons dans ce document un modèle magnéto-mécanique couplé dit modèle multidomaine compatible avec la procédure de contrôle magnétique. Ce modèle analytique permet de simuler le comportement magnétique et magnétostrictif d'un matériau magnétique soumis à un chargement mécanique unidirectionnel. Il a montré une bonne adaptabilité à des états de contraintes et structures magnétiques variées. Le modèle multidomaine a pu être validé dans le cas d'un chargement élastique uniaxial et multixial par un simple recours à une contrainte équivalente magnéto-mécanique. Il a pu également intégrer les éléments nécessaires à la modélisation de l'influence de la plasticité sur l'état magnétique. La plasticité est introduite via un état de contrainteinterne caractérisant une structure hétérogène biphasée. Des corrélations intéressantes entre variables d'écrouissage macroscopiques et propriétés magnétiques ont été élaborées et l'approche a été validée sur un acier dual phases.Nous nous sommes enfin intéressées à a mise en place d'un protocole expérimental novateur assurant un suivi continuel du comportement piézomagnétique du matériau au cours d'un essai de fatigue. Cette technique permet d'estimer la limite d'endurance des matériaux magnétiques.

This study is within a recent research largely motivated by the possibility of development of new non-destructive techniques based on the magneto-mechanical coupling. Thus, the issue is to propose original magnetic methods allowing a quantitative evaluation of the thermo-metallurgicomechnical state of ferromagnetic materials by a simple inverse identification.We propose in this document a coupled magneto-mechanical modeling called multidomain modeling suitable for the non-destructive process. This model is able to simulate magnetic and magnetostrictive behaviors of materials submitted to an uniaxial mechanical loading. It exhibits an adaptability to various mechanical states and magnetic structures. Multidomain modeling provides good results in the case of elastic loading either uniaxial or multiaxial by the use of an equivalent stress. It can also integrate the key elements for modeling the effect of plasticity on the magneticbehavior. Plasticity is introduced through internal stress characterizing heterogenous biphasic structure. Interesting correlations between macroscopic hardening parameters and magnetic properties are shown and the plasticity approach is confirmed by experiments carried out on a dual phase steel.Finally, we propose an experimental protocol allowing in situ continuous investigation of the piezomagnetic behavior during fatigue test. This experimental…

Advisors/Committee Members: Hubert, Olivier (thesis director).

Subjects/Keywords: Contrôle non destructif; Modèle multidomaine; Magnéto-élasticité; Magnétoplasticité; Piézomagnétisme; Non-destructive evaluation; Multidomain modeling; Magneto-elasticity; Magnetoplasticity; Piezomagnetism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lazreg, S. (2011). Identification inverse d’états multiaxiaux élasto-plastiques par méthode magnétique : Inverse identification of multiaxial elasto-plastic states by magnetic method. (Doctoral Dissertation). Cachan, Ecole normale supérieure. Retrieved from http://www.theses.fr/2011DENS0021

Chicago Manual of Style (16^th Edition):

Lazreg, Saïd. “Identification inverse d’états multiaxiaux élasto-plastiques par méthode magnétique : Inverse identification of multiaxial elasto-plastic states by magnetic method.” 2011. Doctoral Dissertation, Cachan, Ecole normale supérieure. Accessed January 22, 2021. http://www.theses.fr/2011DENS0021.

MLA Handbook (7^th Edition):

Lazreg, Saïd. “Identification inverse d’états multiaxiaux élasto-plastiques par méthode magnétique : Inverse identification of multiaxial elasto-plastic states by magnetic method.” 2011. Web. 22 Jan 2021.

Vancouver:

Lazreg S. Identification inverse d’états multiaxiaux élasto-plastiques par méthode magnétique : Inverse identification of multiaxial elasto-plastic states by magnetic method. [Internet] [Doctoral dissertation]. Cachan, Ecole normale supérieure; 2011. [cited 2021 Jan 22]. Available from: http://www.theses.fr/2011DENS0021.

Council of Science Editors:

Lazreg S. Identification inverse d’états multiaxiaux élasto-plastiques par méthode magnétique : Inverse identification of multiaxial elasto-plastic states by magnetic method. [Doctoral Dissertation]. Cachan, Ecole normale supérieure; 2011. Available from: http://www.theses.fr/2011DENS0021

Freie Universität Berlin

11. Jäpel, Maria. Das Gerüstprotein Intersektin 1 unterstützt verschiedene Schritte im Zyklus synaptischer Vesikel.

Degree: 2019, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-2680

► The multidomain scaffold protein intersectin 1 has been implicated in several cellular signaling pathways and processes. The best described function of intersectin 1 is its… (more)

▼ The multidomain scaffold protein intersectin 1 has been implicated in several cellular signaling pathways and processes. The best described function of intersectin 1 is its association with early proteins during clathrin-mediated endocytosis, a process with particular importance in the presynapse in neurons during the reformation of synaptic vesicles. However, intersectin’s numerous domains interact with proteins of diverse processes conceivably involving intersectin 1’s function in further pathways in the presynapse. In the present study we identified so far unknown functions of intersectin 1 in the synaptic vesicle cycle in neurons. Proper cycling of synaptic vesicles is essential for neurotransmission at synapses and includes several processes like clathrin-mediated reformation of synaptic vesicles. In a first project, we identified an accumulation of clathrin-coated vesicles in mice depleted of intersectin 1, a phenotype akin to loss of the endocytic protein endophilin and the phosphatase synaptojanin that is involved in uncoating of clathrin-coated vesicles. Furthermore, we found a direct interaction between intersectin 1 and endophilin in the brain which mediates the association of endophilin with the clathrin machinery. We argue that this association is involved in proper recruitment of the phosphatase synaptojanin to sites of clathrin coated vesicle formation to achieve efficient uncoating of vesicles and thereby reformation of synaptic vesicles. In a second project, we investigated the interaction between intersectin and synapsin, a protein implicated in clustering of reserve pool synaptic vesicles. During sustained neurotransmission synapsin’s dissociation from synaptic vesicles is crucial for replenishment of the recycling pool that comprises release-ready vesicles. We found that the interaction between intersectin and synapsin is regulated by a phosphorylation-dependent intramolecular lock within intersectin that enables binding to synapsin only during neuronal activity. Loss of intersectin in hippocampal neurons resulted in a mislocalization of synapsin in combination with a reduced recycling pool size. We rescued these phenotypes by reexpression of wild-type intersectin but not with a locked, synapsin-binding deficient intersectin mutant. We argue that intersectin associates with synapsin upon activity, prevents premature reclustering of synaptic vesicles and thereby enables replenishment of release-ready vesicles during sustained stimulation. In a third project, we identified an interaction between intersectin and the assembled SNARE complex. The assembly of SNARE complexes is essential for synaptic vesicle fusion at release sites within the active zone. Hippocampal neurons depleted of intersectin displayed exocytic depression in a frequency dependent manner, but also upon sustained stimulation. Additionally, neurons expressing an intersectin binding deficient mutant of the v-SNARE synaptobrevin 2 phenocopied this exocytic depression. We hypothesize that intersectin binds… Advisors/Committee Members: female (gender), Haucke, Volker (firstReferee), Freund, Christian (furtherReferee).

Subjects/Keywords: neurotransmission; synaptic vesicle cycling; multidomain scaffold; SNARE proteins; 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::572 Biochemie

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jäpel, M. (2019). Das Gerüstprotein Intersektin 1 unterstützt verschiedene Schritte im Zyklus synaptischer Vesikel. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-2680

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jäpel, Maria. “Das Gerüstprotein Intersektin 1 unterstützt verschiedene Schritte im Zyklus synaptischer Vesikel.” 2019. Thesis, Freie Universität Berlin. Accessed January 22, 2021. http://dx.doi.org/10.17169/refubium-2680.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jäpel, Maria. “Das Gerüstprotein Intersektin 1 unterstützt verschiedene Schritte im Zyklus synaptischer Vesikel.” 2019. Web. 22 Jan 2021.

Vancouver:

Jäpel M. Das Gerüstprotein Intersektin 1 unterstützt verschiedene Schritte im Zyklus synaptischer Vesikel. [Internet] [Thesis]. Freie Universität Berlin; 2019. [cited 2021 Jan 22]. Available from: http://dx.doi.org/10.17169/refubium-2680.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jäpel M. Das Gerüstprotein Intersektin 1 unterstützt verschiedene Schritte im Zyklus synaptischer Vesikel. [Thesis]. Freie Universität Berlin; 2019. Available from: http://dx.doi.org/10.17169/refubium-2680

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. Léger, Corentin. Conception de protéines artificielles multidomaines : Conception of multidomain artificial proteins.

Degree: Docteur es, Biochimie et biologie structurale, 2018, Université Paris-Saclay (ComUE)

URL: http://www.theses.fr/2018SACLS384

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La création de nouvelles fonctions basées sur la reconnaissance protéique et sur l'assemblage de domaines est un enjeu majeur en biotechnologie et est un moyen… (more)

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La création de nouvelles fonctions basées sur la reconnaissance protéique et sur l'assemblage de domaines est un enjeu majeur en biotechnologie et est un moyen de comprendre les relations structures/fonctions des protéines engagées dans des processus d'interactions. Aujourd’hui, des bibliothèques de protéines artificielles obtenues par ingénierie peuvent être sources de protéines aux propriétés de reconnaissance analogues à celles des dérivés d’anticorps.L’équipe Modélisation et Ingénierie des Protéines a ainsi construit une banque de protéines à motifs structuraux répétés appelées « alphaReps ». Les alphaReps présentent des propriétés remarquables en termes de production et de stabilité. Contrairement à la plupart des anticorps et dérivés d’anticorps, elles peuvent même s’exprimer sous forme fonctionnelle dans le cytoplasme de cellules eucaryotes. De tels objets peuvent donc maintenant être utilisés comme des briques élémentaires en vue d’une ingénierie modulaire. Ainsi la construction de nouvelles fonctions de reconnaissance optimisées tant au niveau de la spécificité que de l’affinité sera possible en réarrangeant et/ou dupliquant ces briques élémentaires.Un premier volet de ce projet de thèse a consisté à construire puis étudier les propriétés biophysiques de protéines bidomaines basées sur les alphaReps afin de mieux comprendre les comportements adoptés par de telles constructions. Outre l’aspect fondamental de cette question, cette étude donnera « les règles » pour moduler de façon contrôlée les interactions entre ces protéines. Les résultats montrent qu'il est possible de créer de nouvelles fonctions par simple ajout d'un linker entre deux alphaReps : avidité, coopérativité, changement de conformation.Dans un second temps, l’objectif a été de développer, à partir des protéines bidomaines précédemment étudiées, de nouveaux biosenseurs basés sur le FRET (Förster Resonance Energy Transfer) pouvant être utilisés in vivo et in vitro. Cette deuxième partie présente deux biosenseurs avec des limites de détection de l'ordre du nanomolaire. Les alphaReps utilisées dans ces constructions pouvant être changées en fonction de la cible souhaitée, il s'agit ici d'une preuve de concept pouvant être généralisée à n'importe quelle cible.Enfin la dernière partie de cette thèse s'est portée sur la conception et l'étude de nouveaux biosenseurs génétiquement codables. Ces biosenseurs présentent notamment l’avantage d’être utilisables immédiatement après production et ne nécessitent donc plus d’étape de couplage chimique. Les résultats obtenus montrent que la création de tels biosenseurs est possible mais qu’une optimisation reste encore nécessaire pour améliorer leur spécificité, leur stabilité et leur capacité de détection.

The creation of new protein functions based on recognition and molecular assembly is not only a major goal in biotechnology but is also a means to understand the relation structure/function of proteins involved in interaction processes. Today, libraries of artificial proteins obtained by engineering can be…

Advisors/Committee Members: Minard, Philippe (thesis director).

Subjects/Keywords: Protéines artificielles; Protéines multidomaines; Biochimie des protéines; Biologie moléculaire; Biophysique; Artificial proteins; Multidomain proteins; Biochemistry; Molecular Biology; Biophysics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Léger, C. (2018). Conception de protéines artificielles multidomaines : Conception of multidomain artificial proteins. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2018SACLS384

Chicago Manual of Style (16^th Edition):

Léger, Corentin. “Conception de protéines artificielles multidomaines : Conception of multidomain artificial proteins.” 2018. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed January 22, 2021. http://www.theses.fr/2018SACLS384.

MLA Handbook (7^th Edition):

Léger, Corentin. “Conception de protéines artificielles multidomaines : Conception of multidomain artificial proteins.” 2018. Web. 22 Jan 2021.

Vancouver:

Léger C. Conception de protéines artificielles multidomaines : Conception of multidomain artificial proteins. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2018. [cited 2021 Jan 22]. Available from: http://www.theses.fr/2018SACLS384.

Council of Science Editors:

Léger C. Conception de protéines artificielles multidomaines : Conception of multidomain artificial proteins. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2018. Available from: http://www.theses.fr/2018SACLS384

Rice University

13. Wickremasinghe, Navindee Charya. Tailored Release of Bioactive Factors from Composite Multidomain Peptide Hydrogels.

Degree: PhD, Natural Sciences, 2016, Rice University

URL: http://hdl.handle.net/1911/96253

► Multidomain peptides (MDP) self-assemble to form nanofibrous scaffolds well suited to tissue engineering and regeneration strategies. MDPs can present bioactive cues that promote vital biological… (more)

▼ Multidomain peptides (MDP) self-assemble to form nanofibrous scaffolds well suited to tissue engineering and regeneration strategies. MDPs can present bioactive cues that promote vital biological responses. Orthogonal self-assembly of MDP and growth factor-loaded liposomes generate supramolecular composite hydrogels. This thesis demonstrates the ability to create a unique hydrogel, developed by stepwise self-assembly of multidomain peptide fibers and liposomes, and presents its potential for in vivo applications. Chapter One of the thesis presents an introduction to the above work with background spanning from the role of self-assembling peptides and hydrogels in tissue engineering, to current strategies for therapeutic angiogenesis and wound healing. Chapter Two addresses the design and characterization of a composite hydrogel containing MDP and liposomes. Results showed that structural and mechanical integrity of the peptide nanofibers, lipid vesicles and the composite gel are retained. The two-component gel allows for controlled release of bioactive factors at multiple time points and indicates bimodal release of two growth factors from the same system. These MDP-Liposome Composites (MLCs) were injected in vivo for targeted, localized delivery of growth factors, and Chapter Three details how they functioned in vivo. Placental growth factor-1 (PlGF-1) was shown to temporally stimulate VEGF-receptor activation in vitro in endothelial cells, and robust vessel formation in vivo. MLCs provide a novel method for the time controlled delivery of growth factors from within highly biocompatible and injectable hydrogels. Time controlled release guided by MLCs induces an unprecedented level of growth factor-mediated neovascular maturity. Use of cytokine-loaded MDP hydrogels to accelerate diabetic wound healing is another in vivo application explored in Chapter Four of this thesis. Delivery of a pro-healing cytokine IL-4 via MDP hydrogels have resulted in enhanced healing of full-thickness dermal wounds on the backs of genetically diabetic mice. Compared to controls, wounds treated with IL-4-MDP composite gels showed higher wound closure, M2 macrophage polarization, re-epithelialization, granulation tissue formation and angiogenesis. The conclusion chapter, Chapter Five, discusses how the above in vivo success of composite MDP hydrogels speaks to their potential to function as a unique protein delivery platform for tissue regeneration. Advisors/Committee Members: Hartgerink, Jeffrey D (advisor), Marti, Angel A (advisor), Mikos, Antonios G (advisor).

Subjects/Keywords: Multidomain peptides; self-assembly; composite hydrogels; liposomes; controlled release; placental growth factor-1; angiogenesis; diabetic wound healing; interleukin-4

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wickremasinghe, N. C. (2016). Tailored Release of Bioactive Factors from Composite Multidomain Peptide Hydrogels. (Doctoral Dissertation). Rice University. Retrieved from http://hdl.handle.net/1911/96253

Chicago Manual of Style (16^th Edition):

Wickremasinghe, Navindee Charya. “Tailored Release of Bioactive Factors from Composite Multidomain Peptide Hydrogels.” 2016. Doctoral Dissertation, Rice University. Accessed January 22, 2021. http://hdl.handle.net/1911/96253.

MLA Handbook (7^th Edition):

Wickremasinghe, Navindee Charya. “Tailored Release of Bioactive Factors from Composite Multidomain Peptide Hydrogels.” 2016. Web. 22 Jan 2021.

Vancouver:

Wickremasinghe NC. Tailored Release of Bioactive Factors from Composite Multidomain Peptide Hydrogels. [Internet] [Doctoral dissertation]. Rice University; 2016. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1911/96253.

Council of Science Editors:

Wickremasinghe NC. Tailored Release of Bioactive Factors from Composite Multidomain Peptide Hydrogels. [Doctoral Dissertation]. Rice University; 2016. Available from: http://hdl.handle.net/1911/96253

14. Audoux, Kévin. Proposition d'un processus d'évaluation multidomaine pour améliorer la conception de produit : Proposal for a multidomain evaluation process to improve product design.

Degree: Docteur es, Conception (AM), 2019, Paris, ENSAM

URL: http://www.theses.fr/2019ENAM0025

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La concurrence industrielle pousse les entreprises à développer de nouveaux produits innovants. En outre, les industriels sont soumis à de plus en plus de contraintes… (more)

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La concurrence industrielle pousse les entreprises à développer de nouveaux produits innovants. En outre, les industriels sont soumis à de plus en plus de contraintes issues des différents acteurs du processus de conception (fabricants, utilisateurs) ou liées aux évolutions de leur environnement (réglementations, technologies). Il leur est donc nécessaire d’adapter leurs activités de conception et plus particulièrement les étapes d’évaluation pour que les produits développés correspondent aux exigences multiples de toutes les parties prenantes. Ces contraintes se traduisent par l’intégration de nouveaux domaines ou l’évolution de domaines existants dans le processus de conception.Dans ce contexte, l’objectif de ces travaux de thèse est de formaliser et d’apporter des méthodes permettant l’évaluation multidomaine dans le processus de conception. Ce manuscrit s’intéresse donc à la problématique suivante : « Comment les phases d’évaluation dans un processus de conception multidomaine peuvent-elles permettre d’accroître les performances du produit à partir des représentations intermédiaires ? ». Pour cela nous proposons une méthodologie permettant d’améliorer le processus d’évaluation en créant un outil d’évaluation multidomaine et en formalisant les étapes du processus d’évaluation pour apporter des méthodes d’amélioration adaptées aux domaines concernés par le produit à concevoir. Des expérimentations sont menées afin de valider leurs apports dans le processus de conception en s’intéressant notamment à trois domaines : l’innovation, la prise en compte des impacts environnementaux et la fabrication additive. Ces expérimentations ont permis de valider la méthodologie de création de l’outil d’évaluation et l’apport des étapes d’amélioration.

Industrial competition is driving companies to develop new innovative products. In addition, industrial companies are increasingly subject to constraints from the various actors in the design process (manufacturers, users) or linked to changes in their environment (regulations, technologies). It is therefore necessary for them to adapt their design activities and more particularly the evaluation steps so that the products developed correspond to the multiple requirements of all stakeholders. These constraints result in the integration of new domains or the evolution of existing domains into the design process.In this context, the objective of this thesis work is to formalize and provide methods for multidomain evaluation in the design process. This manuscript therefore addresses the following question: "How can evaluation phases in a multidomain design process help to increase the performance of intermediate representations? ». To this end, we propose a methodology to improve the evaluation process by creating a multidomain evaluation tool and formalizing the steps of the evaluation process to provide improvement methods adapted to the areas concerned by the product to be designed. Experiments are being carried out to validate their contribution to the design process, focusing in…

Advisors/Committee Members: Aoussat, Améziane (thesis director).

Subjects/Keywords: : évaluation de performances; Méthodologie; Méthode de conception; Outil d'évaluation; Évaluation multidomaine; Performance evaluation; Methodology; Design method; Evaluation tool; Multidomain evaluation; 530

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Audoux, K. (2019). Proposition d'un processus d'évaluation multidomaine pour améliorer la conception de produit : Proposal for a multidomain evaluation process to improve product design. (Doctoral Dissertation). Paris, ENSAM. Retrieved from http://www.theses.fr/2019ENAM0025

Chicago Manual of Style (16^th Edition):

Audoux, Kévin. “Proposition d'un processus d'évaluation multidomaine pour améliorer la conception de produit : Proposal for a multidomain evaluation process to improve product design.” 2019. Doctoral Dissertation, Paris, ENSAM. Accessed January 22, 2021. http://www.theses.fr/2019ENAM0025.

MLA Handbook (7^th Edition):

Audoux, Kévin. “Proposition d'un processus d'évaluation multidomaine pour améliorer la conception de produit : Proposal for a multidomain evaluation process to improve product design.” 2019. Web. 22 Jan 2021.

Vancouver:

Audoux K. Proposition d'un processus d'évaluation multidomaine pour améliorer la conception de produit : Proposal for a multidomain evaluation process to improve product design. [Internet] [Doctoral dissertation]. Paris, ENSAM; 2019. [cited 2021 Jan 22]. Available from: http://www.theses.fr/2019ENAM0025.

Council of Science Editors:

Audoux K. Proposition d'un processus d'évaluation multidomaine pour améliorer la conception de produit : Proposal for a multidomain evaluation process to improve product design. [Doctoral Dissertation]. Paris, ENSAM; 2019. Available from: http://www.theses.fr/2019ENAM0025

University of KwaZulu-Natal

15. Noreldin, Osman A. I. On thermal convective instability in rotating fluids.

Degree: 2018, University of KwaZulu-Natal

URL: https://researchspace.ukzn.ac.za/handle/10413/17206

Abstract available on the PDF. Advisors/Committee Members: Sibanda, Precious. (advisor).

Subjects/Keywords: Fluid rotation.; Magnetic fields.; Rayleigh-Bénard convective instabilities.; Multidomain spectral collocation method.

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APA (6^th Edition):

Noreldin, O. A. I. (2018). On thermal convective instability in rotating fluids. (Thesis). University of KwaZulu-Natal. Retrieved from https://researchspace.ukzn.ac.za/handle/10413/17206

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Noreldin, Osman A I. “On thermal convective instability in rotating fluids.” 2018. Thesis, University of KwaZulu-Natal. Accessed January 22, 2021. https://researchspace.ukzn.ac.za/handle/10413/17206.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Noreldin, Osman A I. “On thermal convective instability in rotating fluids.” 2018. Web. 22 Jan 2021.

Vancouver:

Noreldin OAI. On thermal convective instability in rotating fluids. [Internet] [Thesis]. University of KwaZulu-Natal; 2018. [cited 2021 Jan 22]. Available from: https://researchspace.ukzn.ac.za/handle/10413/17206.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Noreldin OAI. On thermal convective instability in rotating fluids. [Thesis]. University of KwaZulu-Natal; 2018. Available from: https://researchspace.ukzn.ac.za/handle/10413/17206

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

16. Huang, Shuo. A New Multidomain Approach and Fast Direct Solver for the Boundary Element Method.

Degree: PhD, Engineering and Applied Science: Mechanical Engineering, 2017, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1505125721346283

► This dissertation research focuses on the development of new algorithms in the boundary element method (BEM) for solving multidomain problems and a new fast direct… (more)

▼ This dissertation research focuses on the development of new algorithms in the boundary element method (BEM) for solving multidomain problems and a new fast direct linear equation solver for the BEM. The motivation of this research is to further increase the computational efficiencies of the BEM so that BEM models with millions of DOFs (degrees of freedom) can be solved effectively on desktop PCs and those with billions of DOFs on clusters or supercomputers. A simple multidomain fast multipole BEM for solving potential problems is presented first, which can be applied to solve a true multidomain problem or a large-scale single domain problem using the domain decomposition technique. In this multidomain BEM, the coefficient matrix is formed simply by assembling the coefficient matrices of each subdomain and the interface conditions between subdomains without eliminating any unknown variables on the interfaces. Compared with other conventional multidomain BEM approaches, this new approach is more efficient with the fast multipole method, regardless how the subdomains are connected. Instead of solving the linear system of equations directly, the entire coefficient matrix is partitioned and decomposed using Schur complement in this new approach. Numerical results show that the new multidomain fast multipole BEM uses fewer iterations in most cases with the iterative equation solver and less CPU time than the traditional fast multipole BEM in solving large-scale BEM models. A large-scale fuel cell model with more than 6 million elements was solved successfully on a cluster within 3 hours using the new multidomain fast multipole BEM.To accelerate the solution of the multidomain BEM, a new fast direct linear equation solver for the BEM is presented next. The idea of the new fast direct solver stems from the concept of the hierarchical off-diagonal low-rank matrix. The hierarchical off-diagonal low-rank matrix can be decomposed into the multiplication of several diagonal block matrices. The inverse of the hierarchical off-diagonal low-rank matrix can be calculated efficiently with the Sherman-Morrison-Woodbury formula. In this paper, a more general and efficient approach to approximate the coefficient matrix of the BEM with the hierarchical off-diagonal low-rank matrix is proposed. Compared to the current fast direct solver based on the hierarchical off-diagonal low-rank matrix, the proposed method is suitable for solving general 3D boundary element models. Several numerical examples of 3D potential problems with the total number of unknowns up to above 200,000 are presented. The results show that the new fast direct solver can be applied to solve larger 3D BEM models accurately and with better efficiency compared with the conventional direct solvers for the BEM.Discussions and future directions in the research on the fast boundary element method for solving large-scale engineering problems are also presented to end this dissertation. Advisors/Committee Members: Liu, Yijun (Committee Chair).

Subjects/Keywords: Mechanics; Boundary element method; Multidomain problem; Fast direct solver

…29 Figure 2.7. Single-domain and multidomain models of a single solid oxide fuel cell… …deserves some attention in the research. 3 1.3 Multidomain boundary element method 1.3.1… …Literature review The multidomain BEM is usually used to solve the problems with multiple materials… …multidomain BEM approaches for modeling potential problems [41-46]，elastostatic problems… …comprehensive introduction of the multidomain BEM can be found in Ref. [69]. With these…

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APA (6^th Edition):

Huang, S. (2017). A New Multidomain Approach and Fast Direct Solver for the Boundary Element Method. (Doctoral Dissertation). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1505125721346283

Chicago Manual of Style (16^th Edition):

Huang, Shuo. “A New Multidomain Approach and Fast Direct Solver for the Boundary Element Method.” 2017. Doctoral Dissertation, University of Cincinnati. Accessed January 22, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1505125721346283.

MLA Handbook (7^th Edition):

Huang, Shuo. “A New Multidomain Approach and Fast Direct Solver for the Boundary Element Method.” 2017. Web. 22 Jan 2021.

Vancouver:

Huang S. A New Multidomain Approach and Fast Direct Solver for the Boundary Element Method. [Internet] [Doctoral dissertation]. University of Cincinnati; 2017. [cited 2021 Jan 22]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1505125721346283.

Council of Science Editors:

Huang S. A New Multidomain Approach and Fast Direct Solver for the Boundary Element Method. [Doctoral Dissertation]. University of Cincinnati; 2017. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1505125721346283

17. Kang, Namwoo. Multidomain Demand Modeling in Design for Market Systems.

Degree: PhD, Design Science, 2014, University of Michigan

URL: http://hdl.handle.net/2027.42/110471

► Consumers make choices based not only on functional product attributes (e.g., fuel economy) but also on non-functional attributes (e.g., vehicle form). Consequently, ignoring non-functional product… (more)

▼ Consumers make choices based not only on functional product attributes (e.g., fuel economy) but also on non-functional attributes (e.g., vehicle form). Consequently, ignoring non-functional product attributes in demand modeling can lead to product designs less attractive to consumers. This dissertation focuses on two major non-functional product attributes: (i) aesthetic product form as a perceptual product attribute and (ii) services as external product attributes. A limitation in conventional discrete choice analysis is that it handles functional and non-functional attributes within a single demand model. An aesthetic product form is generated by a potentially huge number of geometric variables; thus, it cannot be quantified simply and it is difficult to integrate with functional attributes. Similarly, when considering services, it is challenging to incorporate the relationship (or channel) between product and service attributes (or multiple providers) into a single demand model. This dissertation proposes a multidomain demand modeling approach to integrate functional and non-functional attributes, whose values are decided by different design domains, into a single demand model. We employ consumer choice models from Marketing, systems design optimization from Engineering, machine learning algorithms and human-computer interaction from Computer Science, and location network models from Operations Research within a design optimization framework. This work addresses three demand models: (i) a demand model for engineering and industrial design, (ii) a demand model for engineering and service design, and (iii) a demand model for engineering and operations design. The benefits of this unified approach is demonstrated through three respective design applications including gasoline vehicle design, electric vehicle and charging station location design, and tablet and e-book service design. The contribution of this research is in helping resolve trade-offs between conflicted design domain decisions, by integrating disparate attributes into a multidomain demand model. This work consequently extends the scope of Design for Market Systems from product design to business model design by considering external product attributes. Advisors/Committee Members: Papalambros, Panos Y. (committee member), Feinberg, Fred M. (committee member), Aribarg, Anocha (committee member), Reed, Matthew P. (committee member).

Subjects/Keywords: Design for Market Systems; Multidomain Demand Model; Marketing; Mechanical Engineering; Business and Economics; Engineering

…multidomain demand models . . . . . . . . . . . 127 6.2 Nomenclature for future DMS framework… …ABSTRACT Multidomain Demand Modeling in Design for Market Systems by Namwoo Kang Co-chairs… …This dissertation proposes a multidomain demand modeling approach to integrate functional and… …multidomain demand model. This work consequently extends the scope of Design for Market Systems from… …Frischknecht et al., 2010). The role of the demand model in 1 Figure 1.1: Role of multidomain…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kang, N. (2014). Multidomain Demand Modeling in Design for Market Systems. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/110471

Chicago Manual of Style (16^th Edition):

Kang, Namwoo. “Multidomain Demand Modeling in Design for Market Systems.” 2014. Doctoral Dissertation, University of Michigan. Accessed January 22, 2021. http://hdl.handle.net/2027.42/110471.

MLA Handbook (7^th Edition):

Kang, Namwoo. “Multidomain Demand Modeling in Design for Market Systems.” 2014. Web. 22 Jan 2021.

Vancouver:

Kang N. Multidomain Demand Modeling in Design for Market Systems. [Internet] [Doctoral dissertation]. University of Michigan; 2014. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2027.42/110471.

Council of Science Editors:

Kang N. Multidomain Demand Modeling in Design for Market Systems. [Doctoral Dissertation]. University of Michigan; 2014. Available from: http://hdl.handle.net/2027.42/110471

Université de Bordeaux I

18. Dupé, Valérie. Conception multidisciplinaire de microsystèmes autonomes : Multidisciplinary design of autonomous microsystems.

Degree: Docteur es, Electronique, 2011, Université de Bordeaux I

URL: http://www.theses.fr/2011BOR14372

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Toute action naturelle crée de l’énergie perdue qui pourrait être exploitée pour alimenter nos appareils électriques et mobiles. Nos environnements physiques disposent d’un nombre élevé… (more)

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Toute action naturelle crée de l’énergie perdue qui pourrait être exploitée pour alimenter nos appareils électriques et mobiles. Nos environnements physiques disposent d’un nombre élevé de micro-sources d’énergies ; certes chacune est de faible puissance, mais leur multiplicité pourrait s’avérer significative, notamment dans le cadre du fonctionnement de microsystèmes.C’est le principe précédent qui a conduit nos travaux sur la problématique de la conception de microsystèmes autonomes. Ainsi, pour être innovante, l’ingénierie de microsystèmes doit à la fois s’appuyer sur la culture de l’électronique, de la mécanique mais aussi de l’énergétique. Le processus de conception est fortement pluridisciplinaire et son efficacité réside dans la capacité à mettre en œuvre des méthodologies et des outils :- de conception collaborative,- de capitalisation des connaissances techniques, - d’ingénierie multi-physique,- d’ingénierie intégrée.Sur le base de ces fondamentaux, nous avons développé un outil d’aide à la conception. La méthodologie sous-jacente permet :1- l’analyse et la structuration d’un problème de conception d’un microsystème autonome : cette phase conduit l’identification, la description fonctionnelle et environnementale du système et de son environnement.2- la modélisation des connaissances : une analyse architecturale conduit à la description des composants et des interactions liées au microsystème (directement ou indirectement) puis à la modélisation des comportements,3- la qualification énergétique et le couplage physique : la réutilisation structurée des modèles de connaissances est pilotée pour coupler les modèles physiques et décrire les sources, les puits et les mécanismes énergétiques des environnements,4- la conduite de la recherche de concepts innovants : la base de connaissances, les critères de qualification et la description fonctionnelle préalablement construits sont agencés dans une seule méthode de conception virtuelle pour rechercher des concepts de solutions innovants,5- le pré-dimensionnement : tout en assurant l’intégration des outils spécialisés de simulation (méthode des éléments finis et simulation fonctionnelle), le pré-dimensionnement de microsystèmes autonomes est supportée selon un schéma synthétique, assurant un raisonnement abductif (ou bottom-up)La conjonction des raisonnements physiques, l’intégration des méthodes et des cultures métiers, l’exploration virtuelle des espaces de solutions et la modélisation constituent les bases d’un nouveau moyen d’aide à la conception de microsystèmes autonomes. Cette approche a été déployée pour la conception d’un capteur piézoélectrique autonome.

Any natural action creates lost energy which could be exploited to supply our electrical and mobile appliance. Our physical environments have a high number of micro-energy sources. Admittedly, each one provides low power but their multiplicity could be significant, in particular within the framework of the microsystem operation.The previous observation guided our works towards the problematic of…

Advisors/Committee Members: Fischer, Xavier (thesis director), Briand, Renaud (thesis director).

Subjects/Keywords: Conception pluridisciplinaire et collaborative; Conception intégrée; Modélisation de système; Récupération d'énergie; Microsources d’énergie; Modèle de connaissance; Couplage multi-physique; Microsystème autonome; Collaborative and multidomain design; Integrated design; System modelling; Energie harvesting; Micro-energy sources; Knowledge modelling; Multiphysic coupling; Autonomous microsystem

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dupé, V. (2011). Conception multidisciplinaire de microsystèmes autonomes : Multidisciplinary design of autonomous microsystems. (Doctoral Dissertation). Université de Bordeaux I. Retrieved from http://www.theses.fr/2011BOR14372

Chicago Manual of Style (16^th Edition):

Dupé, Valérie. “Conception multidisciplinaire de microsystèmes autonomes : Multidisciplinary design of autonomous microsystems.” 2011. Doctoral Dissertation, Université de Bordeaux I. Accessed January 22, 2021. http://www.theses.fr/2011BOR14372.

MLA Handbook (7^th Edition):

Dupé, Valérie. “Conception multidisciplinaire de microsystèmes autonomes : Multidisciplinary design of autonomous microsystems.” 2011. Web. 22 Jan 2021.

Vancouver:

Dupé V. Conception multidisciplinaire de microsystèmes autonomes : Multidisciplinary design of autonomous microsystems. [Internet] [Doctoral dissertation]. Université de Bordeaux I; 2011. [cited 2021 Jan 22]. Available from: http://www.theses.fr/2011BOR14372.

Council of Science Editors:

Dupé V. Conception multidisciplinaire de microsystèmes autonomes : Multidisciplinary design of autonomous microsystems. [Doctoral Dissertation]. Université de Bordeaux I; 2011. Available from: http://www.theses.fr/2011BOR14372

University of Exeter

19. Kothamachu, Varun Bhaskar. An investigation into dynamic and functional properties of prokaryotic signalling networks.

Degree: PhD, 2016, University of Exeter

URL: http://hdl.handle.net/10871/26597

► In this thesis, I investigate dynamic and computational properties of prokaryotic signalling architectures commonly known as the Two Component Signalling networks and phosphorelays. The aim… (more)

▼ In this thesis, I investigate dynamic and computational properties of prokaryotic signalling architectures commonly known as the Two Component Signalling networks and phosphorelays. The aim of this study is to understand the information processing capabilities of different prokaryotic signalling architectures by examining the dynamics they exhibit. I present original investigations into the dynamics of different phosphorelay architectures and identify network architectures that include a commonly found four step phosphorelay architecture with a capacity for tuning its steady state output to implement different signal-response behaviours viz. sigmoidal and hyperbolic response. Biologically, this tuning can be implemented through physiological processes like regulating total protein concentrations (e.g. via transcriptional regulation or feedback), altering reaction rate constants through binding of auxiliary proteins on relay components, or by regulating bi-functional activity in relays which are mediated by bifunctional histidine kinases. This study explores the importance of different biochemical arrangements of signalling networks and their corresponding response dynamics. Following investigations into the significance of various biochemical reactions and topological variants of a four step relay architecture, I explore the effects of having different types of proteins in signalling networks. I show how multi-domain proteins in a phosphorelay architecture with multiple phosphotransfer steps occurring on the same protein can exhibit multistability through a combination of double negative and positive feedback loops. I derive a minimal multistable (core) architecture and show how component sharing amongst networks containing this multistable core can implement computational logic (like AND, OR and ADDER functions) that allows cells to integrate multiple inputs and compute an appropriate response. I examine the genomic distribution of single and multi domain kinases and annotate their partner response regulator proteins across prokaryotic genomes to find the biological significance of dynamics that these networks embed and the processes they regulate in a cell. I extract data from a prokaryotic two component protein database and take a sequence based functional annotation approach to identify the process, function and localisation of different response regulators as signalling partners in these networks. In summary, work presented in this thesis explores the dynamic and computational properties of different prokaryotic signalling networks and uses them to draw an insight into the biological significance of multidomain sensor kinases in living cells. The thesis concludes with a discussion on how this understanding of the dynamic and computational properties of prokaryotic signalling networks can be used to design synthetic circuits involving different proteins comprising two component and phosphorelay architectures.

Subjects/Keywords: 571.7; multistability; prokaryotes; two component signalling networks; multidomain proteins; Boolean logic; synthetic biology; Phosphorylation; Topology; Signal processing; Cell signaling structures; Bacillus subtilis; Biochemical simulations; Chemotaxis; Protein kinase; signaling cascade; Signal termination; Dynamic response; modelling; ordinary differential equations; ODE; steady state; bistability

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kothamachu, V. B. (2016). An investigation into dynamic and functional properties of prokaryotic signalling networks. (Doctoral Dissertation). University of Exeter. Retrieved from http://hdl.handle.net/10871/26597

Chicago Manual of Style (16^th Edition):

Kothamachu, Varun Bhaskar. “An investigation into dynamic and functional properties of prokaryotic signalling networks.” 2016. Doctoral Dissertation, University of Exeter. Accessed January 22, 2021. http://hdl.handle.net/10871/26597.

MLA Handbook (7^th Edition):

Kothamachu, Varun Bhaskar. “An investigation into dynamic and functional properties of prokaryotic signalling networks.” 2016. Web. 22 Jan 2021.

Vancouver:

Kothamachu VB. An investigation into dynamic and functional properties of prokaryotic signalling networks. [Internet] [Doctoral dissertation]. University of Exeter; 2016. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10871/26597.

Council of Science Editors:

Kothamachu VB. An investigation into dynamic and functional properties of prokaryotic signalling networks. [Doctoral Dissertation]. University of Exeter; 2016. Available from: http://hdl.handle.net/10871/26597

KTH

20. Oldelius, David. Master Data Management-studie om nästa entiteto och leverantör för Scania.

Degree: Health Informatics and Logistics, 2018, KTH

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-230108

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Stora företag har olika avdelningar där informationen från dessa måste hanteras. Master Data Management(MDM) är ett informationshanteringssystem för att hantera information från olika källor.… (more)

Subjects/Keywords: Data governance; master data; Master Data Management; domain; multidomain; data quality; MDM; information management; Data governance; masterdata; Master Data Management; domän; multidomän; datakvalité; MDM; informationshantering; Information Systems; Systemvetenskap, informationssystem och informatik

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Oldelius, D. (2018). Master Data Management-studie om nästa entiteto och leverantör för Scania. (Thesis). KTH. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-230108

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Oldelius, David. “Master Data Management-studie om nästa entiteto och leverantör för Scania.” 2018. Thesis, KTH. Accessed January 22, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-230108.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Oldelius, David. “Master Data Management-studie om nästa entiteto och leverantör för Scania.” 2018. Web. 22 Jan 2021.

Vancouver:

Oldelius D. Master Data Management-studie om nästa entiteto och leverantör för Scania. [Internet] [Thesis]. KTH; 2018. [cited 2021 Jan 22]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-230108.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Oldelius D. Master Data Management-studie om nästa entiteto och leverantör för Scania. [Thesis]. KTH; 2018. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-230108

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. Nguyen Thi, Minh-Ha. Molecular recognition of ubiquitin and Lysine 63 linked diubiquitin by STAM2 : the effect of the linkers length and flexibility : La reconnaissance de l'ubiquitine et de la diubiquitine Lysine 63 par la protéine STAM2 : l'effet de la longueur et de la flexibilité des linkers.

Degree: Docteur es, Résonance magnétique nucléaire, 2019, Lyon

URL: http://www.theses.fr/2019LYSE1321

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Les interactions protéine-proteine sont considérées comme un domaine de recherche important puisqu’elles contrôlent la plupart des processus cellulaires. Chez les cellules eucaryotes, les protéines multi-domaines… (more)

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Les interactions protéine-proteine sont considérées comme un domaine de recherche important puisqu’elles contrôlent la plupart des processus cellulaires. Chez les cellules eucaryotes, les protéines multi-domaines (MDP), constituées d’au moins deux domaines, représentent plus de 70 % des protéines. Au sein d’une MDP, ces domaines peuvent être identiques ou différents et sont reliés par un segment intrinsèquement désordonné de longueur et de flexibilité variable. Ces protéines peuvent alors adopter de multiples conformations dans l’espace et interagir de manière spécifique avec leurs partenaires biologiques. Malgré de nombreux efforts de recherche dans le domaine, certaines questions restent encore non résolues ou nécessitent une étude approfondie. Mon projet de recherche est d’étudier et de définir le rôle des segments intrinsèquement désordonnés de la protéine STAM2 (Signal transducing adapter molecule 2) impliquée dans la machinerie ESCRT (Endosomal Sorting Complexe Required for Transport) , première étape dans le processus de dégradation lysosomale. Plus précisément, l’étude se focalise sur les effets de la flexibilité et la dynamique de ces segments dans le cas du processus de reconnaissance moléculaire entre STAM2 et l’ubiquitine ou di-ubiquitine. Différents mutants ont alors été conçus : soit avec un domaine totalement ou partiellement supprimé, soit avec un raccourcissement ou une suppression complète du segment ou soit avec de multiples mutations dans la séquence peptidique du segment. Ces différents construits ont été analysés en utilisant une combinaison de techniques biophysiques telles que la relaxation de spin par résonance magnétique nucléaire (RMN), la diffusion des rayons X aux petits angles (SAXS) et le dichroïsme circulaire (CD). Il a alors été démontré qu’une altération du segment désordonné peut entraîner un changement de la dynamique de la protéine et/ou un changement conformationnel. La modification de ce segment influe sur le mouvement inter-domaine et modifie l’affinité entre les construits de STAM2 et la di-ubiquitine sans modifier l’intégrité de chaque domaine et de leur site de liaison. En résumé, les segments intrinsèquement désordonnés procurent une certaine plasticité à la protéine ce qui lui permet de s’adapter et de remplir sa fonction biologique. Il est alors possible d’imaginer dans un futur proche que ces segments soient la nouvelle génération de cibles thérapeutiques pouvant réduire ou supprimer certaines interactions nocives

Protein-protein interaction is considered as an important field of research, as it is the key to control variable cell processes and pathways. In eucaryotic cells, multidomain proteins (MDPs), which consist of more than one domain, take up over 70 % of the pool. Those identical or different domains of a MDP are connected to each other by a linker of variable length and flexibility. For long flexible linker, it allows the protein to sample a wide range of conformation and to adjust interaction in a subtle way. Despite numerous efforts of research on the…

Advisors/Committee Members: Walker, Olivier (thesis director), Hologne, Maggy (thesis director).

Subjects/Keywords: Résonance Magnétique Nucléaire; Protéine multi-domaine; Linker; STAM2; Ubiquitine; Flexibilité; Diffusion de rayon X à petite angle; Diubiquitine Lysine 63; Nuclear Magnetic Resonance; Small angle X-ray Scattering; Multidomain protein; Linker; STAM2; Ubiquitin; Lysine 63 linked diubiquitin; Flexibility; 540

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nguyen Thi, M. (2019). Molecular recognition of ubiquitin and Lysine 63 linked diubiquitin by STAM2 : the effect of the linkers length and flexibility : La reconnaissance de l'ubiquitine et de la diubiquitine Lysine 63 par la protéine STAM2 : l'effet de la longueur et de la flexibilité des linkers. (Doctoral Dissertation). Lyon. Retrieved from http://www.theses.fr/2019LYSE1321

Chicago Manual of Style (16^th Edition):

Nguyen Thi, Minh-Ha. “Molecular recognition of ubiquitin and Lysine 63 linked diubiquitin by STAM2 : the effect of the linkers length and flexibility : La reconnaissance de l'ubiquitine et de la diubiquitine Lysine 63 par la protéine STAM2 : l'effet de la longueur et de la flexibilité des linkers.” 2019. Doctoral Dissertation, Lyon. Accessed January 22, 2021. http://www.theses.fr/2019LYSE1321.

MLA Handbook (7^th Edition):

Nguyen Thi, Minh-Ha. “Molecular recognition of ubiquitin and Lysine 63 linked diubiquitin by STAM2 : the effect of the linkers length and flexibility : La reconnaissance de l'ubiquitine et de la diubiquitine Lysine 63 par la protéine STAM2 : l'effet de la longueur et de la flexibilité des linkers.” 2019. Web. 22 Jan 2021.

Vancouver:

Nguyen Thi M. Molecular recognition of ubiquitin and Lysine 63 linked diubiquitin by STAM2 : the effect of the linkers length and flexibility : La reconnaissance de l'ubiquitine et de la diubiquitine Lysine 63 par la protéine STAM2 : l'effet de la longueur et de la flexibilité des linkers. [Internet] [Doctoral dissertation]. Lyon; 2019. [cited 2021 Jan 22]. Available from: http://www.theses.fr/2019LYSE1321.

Council of Science Editors:

Nguyen Thi M. Molecular recognition of ubiquitin and Lysine 63 linked diubiquitin by STAM2 : the effect of the linkers length and flexibility : La reconnaissance de l'ubiquitine et de la diubiquitine Lysine 63 par la protéine STAM2 : l'effet de la longueur et de la flexibilité des linkers. [Doctoral Dissertation]. Lyon; 2019. Available from: http://www.theses.fr/2019LYSE1321

Indian Institute of Science

22. Mohanty, Smita. Functionally Interacting Proteins : Analyses And Prediction.

Degree: PhD, Faculty of Science, 2016, Indian Institute of Science

URL: http://etd.iisc.ac.in/handle/2005/2534

► Functional interaction of proteins is a broad term encompassing many different types of associations that are observed amongst proteins. It includes direct non-covalent interactions where… (more)

▼ Functional interaction of proteins is a broad term encompassing many different types of associations that are observed amongst proteins. It includes direct non-covalent interactions where the interacting proteins physically associate using an interface. There are also many protein-protein interactions where the proteins concerned are not involved in direct physical interactions but affect each other’s functions. Central focus of this thesis is to understand the various aspects of functionally interacting proteins. Chapter 1 of this thesis provides an introduction to functional interactions between proteins and discusses the key developments available in the literature. This chapter discusses the different types of functional associations observed commonly between proteins. Various approaches developed over time to elucidate such interactions have also been discussed. This chapter highlights how functional interactions between proteins have been helpful in understanding different cellular processes such as organization of metabolic pathways. The chapter emphasizes the importance of functional interactions between proteins, providing a motivation for development of methods with enhanced accuracy and sensitivity for the prediction of functional interactions. In this thesis, domain families which are found to co-exist in multidomain proteins have been used to understand and subsequently predict functional associations amongst proteins. Domains in proteins typically serve as modules associated with specific functions. There exist proteins with a single domain which describes the entire function of a protein, while there also exist proteins containing multiple domains, where various domains in unison describe the complete function of the multidomain protein. Therefore, by virtue of “guilt by association” domain families found together in multidomain proteins are functionally linked. This forms the basic premise for understanding functional association amongst proteins and is explained in great detail in the Introduction chapter. Using domain families which co-occur in multidomain proteins as the basis for functional association has many merits. First, as stated before, constituent domain families act as effective descriptors of function(s) of proteins. For example, members of SH3 domain family mediate protein-protein interactions by binding to regions with polyproline conformation irrespective of the multidomain protein in which it occurs. Thus, studies of domain families co-existing in multidomain proteins act as an accurate resource of functional associations between proteins. Also, assignment of domains to a protein relies on homology detection which has achieved a high level of reliability, thus, resulting in reasonably accurate prediction of functions. Such approaches enable exhaustive coverage of many diverse proteins including many multidomain proteins leading to detection of large numbers of functional associations between domains of multidomain proteins. Given the advantages attributed to functionally linked… Advisors/Committee Members: Srinivasan, N (advisor).

Subjects/Keywords: Proteins - Functional Interactions; Multidomain Proteins; Functionlly Interacting Proteins; Tethered Domain Families; Protein-Protein Interactions; Protein Analysis; Eukaryotes - Functionally Interacting Proteins; Plasmodium Falciparum - Metabolic Proteins; Metabolic Proteins; GTPases and GEFs (Guanine Nucleotide Exchange Factor) Interaction; Dictyostelium Discoideum - Ribosomal Proteins; Ribosomal Protein; Biochemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mohanty, S. (2016). Functionally Interacting Proteins : Analyses And Prediction. (Doctoral Dissertation). Indian Institute of Science. Retrieved from http://etd.iisc.ac.in/handle/2005/2534

Chicago Manual of Style (16^th Edition):

Mohanty, Smita. “Functionally Interacting Proteins : Analyses And Prediction.” 2016. Doctoral Dissertation, Indian Institute of Science. Accessed January 22, 2021. http://etd.iisc.ac.in/handle/2005/2534.

MLA Handbook (7^th Edition):

Mohanty, Smita. “Functionally Interacting Proteins : Analyses And Prediction.” 2016. Web. 22 Jan 2021.

Vancouver:

Mohanty S. Functionally Interacting Proteins : Analyses And Prediction. [Internet] [Doctoral dissertation]. Indian Institute of Science; 2016. [cited 2021 Jan 22]. Available from: http://etd.iisc.ac.in/handle/2005/2534.

Council of Science Editors:

Mohanty S. Functionally Interacting Proteins : Analyses And Prediction. [Doctoral Dissertation]. Indian Institute of Science; 2016. Available from: http://etd.iisc.ac.in/handle/2005/2534

Universidade Estadual de Campinas

23. Silva, Júlio César da. Estudos de macromoléculas biológicas parcialmente desestruturadas usando espalhamento de raios-X: Study of partially unstructured macromolecules using X-ray scattering.

Degree: 2010, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/277988

► Abstract: The traditional techniques for structural characterization of macromolecules are based on a compact and structured conformation of the macromolecule. Flexible or disordered regions have… (more)

▼ Abstract: The traditional techniques for structural characterization of macromolecules are based on a compact and structured conformation of the macromolecule. Flexible or disordered regions have usually been regarded as a great hindrance to techniques like X-ray protein crystallography and nuclear magnetic resonance (NMR). The need to study functional activity of natively unfolded proteins and flexible multidomain proteins came to the light rather recently, defying the classical structure¿function paradigm where a protein must have a well-defined 3-D structure to be functional. In this type of situation, the small-angle X-ray scattering (SAXS) technique appears as a unique tool to deal with this problem. Indeed, the application of SAXS methods to the characterization of soft matter (e.g. polymers) and macromolecules in solution has already succeeded during the last years. In this work we decided to face the challenge of characterizing proteins that do not have a well defined structure. The SAXS experimental technique as well as the mathematical methods and calculations needed special attention in order to be correctly applied to study the specific problem of unstructured proteins in solution. Thus, it was possible to find evidence of the structural details of these proteins and obtain a low resolution 3-D average structure. Here we present the study of two proteins that belong to the group of natively unfolded proteins: (1) The FEZ1 protein, which is necessary for axon growth, and (2) the proteins indentified as Ki-1/57, which is found in diverse cancer cells mainly in lymphatic systems tumors. We also studied some flexible multidomain proteins: (1) two chaperones from the groups of HSP40 (the proteínas Sis1 e Ydj1), and two mutant constructions where some domains were deleted; (2) the heterogeneous ribonucleoprotein hnRNP-Q which is related to an array of important functions of RNA. Several SAXS experiments were performed providing overall parameters and important shape information about those proteins in solution. Low resolution models for the possible conformations of these proteins were restored from the SAXS curves using ab initio modeling methods combined with rigid body modeling. The SAXS results provided a unique structural background for the biologists to deal with the function of these proteins. SAXS experiments with proteins in solution demand the use of a specific instrumentation properly developed for those studies. So, it is important to mention that, throughout the duration of this doctorate, specific instrumentation development and testing was done together with the technical staff of the Brazilian Synchrotron Light Laboratory (LNLS, Campinas, SP, Brazil), collaborating with the commissioning of the new SAXS2 workstation, completed in 2008 Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Torriani, Iris Concepcion Linares de, 1934- (advisor), Universidade Estadual de Campinas. Instituto de Física Gleb Wataghin (institution), Programa de Pós-Graduação em Física (nameofprogram), Castro, Antonio Rubens Britto de (committee member), Aguiar, Marcus Aloizio Martinez de (committee member), Lima, Mauricio Trambaioli da Rocha e (committee member), Santoro, Marcelo Matos (committee member).

Subjects/Keywords: Raios X - Espalhamento a baixo ângulo; Proteínas intrinsecamente desestruturadas; Proteínas multidomínios; Flexibilidade intramolecular; Small-angle X-ray scattering; Proteins intrinsically desestruturadas; Multidomain proteins; Intramolecular flexibility

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Silva, J. C. d. (2010). Estudos de macromoléculas biológicas parcialmente desestruturadas usando espalhamento de raios-X: Study of partially unstructured macromolecules using X-ray scattering. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/277988

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Silva, Júlio César da. “Estudos de macromoléculas biológicas parcialmente desestruturadas usando espalhamento de raios-X: Study of partially unstructured macromolecules using X-ray scattering.” 2010. Thesis, Universidade Estadual de Campinas. Accessed January 22, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/277988.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Silva, Júlio César da. “Estudos de macromoléculas biológicas parcialmente desestruturadas usando espalhamento de raios-X: Study of partially unstructured macromolecules using X-ray scattering.” 2010. Web. 22 Jan 2021.

Vancouver:

Silva JCd. Estudos de macromoléculas biológicas parcialmente desestruturadas usando espalhamento de raios-X: Study of partially unstructured macromolecules using X-ray scattering. [Internet] [Thesis]. Universidade Estadual de Campinas; 2010. [cited 2021 Jan 22]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/277988.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Silva JCd. Estudos de macromoléculas biológicas parcialmente desestruturadas usando espalhamento de raios-X: Study of partially unstructured macromolecules using X-ray scattering. [Thesis]. Universidade Estadual de Campinas; 2010. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/277988

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

24. Záleský, Martin. Nemocnice v Pardubicích - příprava a organizace přístavby pavilonu: Hospital in Pardubice - preparation and organization of extension Pavilion.

Degree: 2018, Brno University of Technology

URL: http://hdl.handle.net/11012/37716

► This thesis discusses the preparation and organization of the extension construction of multi-purpose Pavilion in Pardubice hospital. The thesis contains a summary accompanying technical report,… (more)

Subjects/Keywords: Multioborový pavilon; CFA piloty; železobetonový skelet; kontaktní zateplovací systém; kontrolní a zkušební plán; strojní sestava; bezpečnost a ochrana zdraví při práci; položkový rozpočet; časový harmonogram; hluková studie; smlouva o dílo; projekt zařízení staveniště; stavební situace; Multidomain pavilion; CFA piles; reinforced concrete structure; contact thermal insulation system; controlling test plan; mechanical assembly; occupational safety and health; itemized budget; schedule; noise study; work contract; project site facilities; building situation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Záleský, M. (2018). Nemocnice v Pardubicích - příprava a organizace přístavby pavilonu: Hospital in Pardubice - preparation and organization of extension Pavilion. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/37716

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Záleský, Martin. “Nemocnice v Pardubicích - příprava a organizace přístavby pavilonu: Hospital in Pardubice - preparation and organization of extension Pavilion.” 2018. Thesis, Brno University of Technology. Accessed January 22, 2021. http://hdl.handle.net/11012/37716.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Záleský, Martin. “Nemocnice v Pardubicích - příprava a organizace přístavby pavilonu: Hospital in Pardubice - preparation and organization of extension Pavilion.” 2018. Web. 22 Jan 2021.

Vancouver:

Záleský M. Nemocnice v Pardubicích - příprava a organizace přístavby pavilonu: Hospital in Pardubice - preparation and organization of extension Pavilion. [Internet] [Thesis]. Brno University of Technology; 2018. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/11012/37716.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Záleský M. Nemocnice v Pardubicích - příprava a organizace přístavby pavilonu: Hospital in Pardubice - preparation and organization of extension Pavilion. [Thesis]. Brno University of Technology; 2018. Available from: http://hdl.handle.net/11012/37716

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université Paris-Sud – Paris XI

25. Hammouch, Zohra. Développement d’une méthode numérique pour les équations de Navier-Stokes en approximation anélastique : application aux instabilités de Rayleigh-Taylor : Developpement of a numerical method for Navier-Stokes equations in anelastic approximation : application to Rayleigh-Taylor instabilities.

Degree: Docteur es, Physique : instabilités hydrodynamiques, 2012, Université Paris-Sud – Paris XI

URL: http://www.theses.fr/2012PA112086

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L’approximation dite « anélastique » permet de filtrer les ondes acoustiques grâce à un développement asymptotique deséquations de Navier-Stokes, réduisant ainsi le pas en temps… (more)

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L’approximation dite « anélastique » permet de filtrer les ondes acoustiques grâce à un développement asymptotique deséquations de Navier-Stokes, réduisant ainsi le pas en temps moyen, lors de la simulation numérique du développement d’instabilités hydrodynamiques. Ainsi, les équations anélastiques sont établies pour un mélange de deux fluides pour l’instabilité de Rayleigh-Taylor. La stabilité linéaire de l’écoulement est étudiée pour la première fois pour des fluides parfaits, par la méthode des modes normaux, dans le cadre de l’approximation anélastique. Le problème de Stokes issu des équations de Navier-Stokes sans les termes non linéaires (une partie de la poussée d’Archiméde est prise en compte) est défini ; l’éllipticité est démontrée, l’étude des modes propres et l’invariance liée à la pression sont détaillés. La méthode d’Uzawa est étendue à l’anélastique en mettant en évidence le découplage des vitesses en 3D, le cas particulier k = 0 et les modes parasites de pression. Le passage au multidomaine a permis d’établir les conditions de raccord (raccord Co de la pression sans condition aux limites physiques). Les algorithmes et l’implantation dans le code AMENOPHIS sont validés par les comparaisons de l’opérateur d’Uzawa développé en Fortran et à l’aide de Mathematica. De plus des résultats numériques ont été comparés à une expérience avec des fluides incompressibles. Finalement, une étude des solutions numériques obtenues avec les options anélastique et compressible a été menée. L’étude de l’influence de la stratification initiale des deux fluides sur le développement de l’instabilité de Rayleigh-Taylor est amorcée.

The « anelastic » approximation allows us to filter the acoustic waves thanks to an asymptotic development of the Navier-Stokes equations, so increasing the averaged time step, during the numerical simulation of hydrodynamic instabilitiesdevelopment. So, the anelastic equations for a two fluid mixture in case of Rayleigh-Taylor instability are established.The linear stability of Rayleigh-Taylor flow is studied, for the first time, for perfect fluids in the anelastic approximation.We define the Stokes problem resulting from Navier-Stokes equations without the non linear terms (a part of the buoyancyis considered) ; the ellipticity is demonstrated, the eigenmodes and the invariance related to the pressure are detailed.The Uzawa’s method is extended to the anelastic approximation and shows the decoupling speeds in 3D, the particular casek = 0 and the spurius modes of pressure. Passing to multidomain allowed to establish the transmission conditions.The algorithms and the implementation in the existing program are validated by comparing the Uzawa’s operator inFortran and Mathematica langages, to an experiment with incompressible fluids and results from anelastic and compressiblenumerical simulations. The study of the influence of the initial stratification of both fluids on the development of the Rayleigh-Taylor instability is initiated.

Advisors/Committee Members: Gauthier, Serge (thesis director), Labrosse, Gérard (thesis director).

Subjects/Keywords: Approximation anélastique; Méthode d’Uzawa; Problème de Stokes; Méthode pseudo-spectrale multidomaine; Maillage auto-adaptatif; Parallélisation MPI; Equations de Navier-Stokes; Ecoulements stratifiés; Stratification; Fluides miscibles; Instabilité de Rayleigh-Taylor; Analyse de stabilité linéaire; Couche de mélange; Anelastic approximation; Uzawa’s method; Stokes problem; Multidomain pseudo-spectral method; Autoadaptive meshing; MPI parallelism; Navier-Stokes equations; Stratified flows; Stratification; Miscible fluids; Rayleigh-Taylor instability; Linear stability analysis; Mixing layer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hammouch, Z. (2012). Développement d’une méthode numérique pour les équations de Navier-Stokes en approximation anélastique : application aux instabilités de Rayleigh-Taylor : Developpement of a numerical method for Navier-Stokes equations in anelastic approximation : application to Rayleigh-Taylor instabilities. (Doctoral Dissertation). Université Paris-Sud – Paris XI. Retrieved from http://www.theses.fr/2012PA112086

Chicago Manual of Style (16^th Edition):

Hammouch, Zohra. “Développement d’une méthode numérique pour les équations de Navier-Stokes en approximation anélastique : application aux instabilités de Rayleigh-Taylor : Developpement of a numerical method for Navier-Stokes equations in anelastic approximation : application to Rayleigh-Taylor instabilities.” 2012. Doctoral Dissertation, Université Paris-Sud – Paris XI. Accessed January 22, 2021. http://www.theses.fr/2012PA112086.

MLA Handbook (7^th Edition):

Hammouch, Zohra. “Développement d’une méthode numérique pour les équations de Navier-Stokes en approximation anélastique : application aux instabilités de Rayleigh-Taylor : Developpement of a numerical method for Navier-Stokes equations in anelastic approximation : application to Rayleigh-Taylor instabilities.” 2012. Web. 22 Jan 2021.

Vancouver:

Hammouch Z. Développement d’une méthode numérique pour les équations de Navier-Stokes en approximation anélastique : application aux instabilités de Rayleigh-Taylor : Developpement of a numerical method for Navier-Stokes equations in anelastic approximation : application to Rayleigh-Taylor instabilities. [Internet] [Doctoral dissertation]. Université Paris-Sud – Paris XI; 2012. [cited 2021 Jan 22]. Available from: http://www.theses.fr/2012PA112086.

Council of Science Editors:

Hammouch Z. Développement d’une méthode numérique pour les équations de Navier-Stokes en approximation anélastique : application aux instabilités de Rayleigh-Taylor : Developpement of a numerical method for Navier-Stokes equations in anelastic approximation : application to Rayleigh-Taylor instabilities. [Doctoral Dissertation]. Université Paris-Sud – Paris XI; 2012. Available from: http://www.theses.fr/2012PA112086

Open Access Theses and Dissertations