Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

Sorted by: relevance · author · university · dateNew search

You searched for subject:(Multicomponent crystals). Showing records 1 – 2 of 2 total matches.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters


Indian Institute of Science

1. Dasgupta, Archi. Analysis Of Intermolecular Interactions In Pharmaceutical Salts And Cocrystals.

Degree: MS, Faculty of Science, 2013, Indian Institute of Science

The studies on cocrystals and salts presented in the the chapters clearly bring out the influence of intermolecular interactions as the main evaluators of the cocrystal-salt regime. The observations made in Chapter 2 indicate that in case if the cocrystal formation is through hydrogen bonds the location of the proton decides the nature of the complex in the energy landscape. The observation that the coformer controls the topology of intermolecular space as demonstrated in Chapter 3 provides insights into the importance of directionality rather than strength of intermolecular interactions. Indeed halogen bonding in cocrystals gain importance in this context. Advisors/Committee Members: Row, T N Guru (advisor).

Subjects/Keywords: Intermolecular Interactions; Pharmaceutical Salts; Cocrystals; Lamotrigine Complexes; Entacapone - Amine Complexes; Multicomponent Crystals; Active Pharmaceutical Ingredients (APIs); Pharmaceutical Solids; Theoretical Chemistry

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Dasgupta, A. (2013). Analysis Of Intermolecular Interactions In Pharmaceutical Salts And Cocrystals. (Masters Thesis). Indian Institute of Science. Retrieved from http://etd.iisc.ac.in/handle/2005/2123

Chicago Manual of Style (16th Edition):

Dasgupta, Archi. “Analysis Of Intermolecular Interactions In Pharmaceutical Salts And Cocrystals.” 2013. Masters Thesis, Indian Institute of Science. Accessed December 04, 2020. http://etd.iisc.ac.in/handle/2005/2123.

MLA Handbook (7th Edition):

Dasgupta, Archi. “Analysis Of Intermolecular Interactions In Pharmaceutical Salts And Cocrystals.” 2013. Web. 04 Dec 2020.

Vancouver:

Dasgupta A. Analysis Of Intermolecular Interactions In Pharmaceutical Salts And Cocrystals. [Internet] [Masters thesis]. Indian Institute of Science; 2013. [cited 2020 Dec 04]. Available from: http://etd.iisc.ac.in/handle/2005/2123.

Council of Science Editors:

Dasgupta A. Analysis Of Intermolecular Interactions In Pharmaceutical Salts And Cocrystals. [Masters Thesis]. Indian Institute of Science; 2013. Available from: http://etd.iisc.ac.in/handle/2005/2123

2. Bahmed, Amina. The design and synthesis of novel pro-drugs for the treatment of nephropathic cystinosis.

Degree: PhD, 2015, Robert Gordon University

Cystinosis is a metabolic disorder characterised by the abnormal accumulation of the amino acid cystine in cells leading to a slow destruction of all major organs. If patients diagnosed with cystinosis are untreated, death due to kidney failure ensues in the second decade of life. A number of studies have shown the ability of the drug cysteamine (Cystagon®) to lower cystine accumulation within cells resulting in reduced organ and tissue damage. Cysteamine therapy however, is associated with a number of side effects involving the gastrointestinal tract and the central nervous system. Most of these arise due to the large amount of cysteamine present in the stomach and gut following administration. In addition, cysteamine possesses an unpleasant taste and smell, resulting in poor patient compliance. In an attempt to overcome these problems, a number of pro-drug derivatives of cysteamine and cystamine, the disulfide analogue of cysteamine, have been synthesised and evaluated. Pro-drugs were synthesised using a route established in our laboratories. Briefly, cystamine dihydrochloride was basified and allowed to react with a number of cyclic anhydrides under basic conditions. The resulting di-acids were reacted with carbonyldiimidazole and monoBoc-cystamine to yield the desired pro-drugs. Removal of the tBoc-protecting group was achieved in a facile manner by use of trifluoroacetic acid to yield product. The efficacy of the synthesised pro-drugs was determined by incubation of 50μM compound in a suspension of cultured cystinotic fibroblasts, with 50μM cysteamine as control. Cell growth was measured at 72 h and the level of thiol determined. All except one of the pro-drugs tested were significantly more effective than the control at lowering the cystine burden of the cells. Further work will concentrate on repeating these studies and evaluating a more robust Structure Activity Relationship for these compounds. The overall aim of all this work remains the production of an odourless, tasteless and orally active treatment for cystinosis and, if possible, improve on the current dosing regimen of every 6h. By using pro-drugs, cysteamine will be chemically camouflaged and hence, the side effects associated with its administration will be minimised or even entirely abolished.

Subjects/Keywords: 610; Cystagon; Cysteamine; Cystamine; Pro-drugs; Multicomponent crystals; Nephropathic Cystinosis; Peptide synthesis

…Research Progress 48 1.7. Aims of Project 50 CHAPTER 2 Multicomponent Crystals 52 2.1… …Multicomponent crystals 53 2.1.1. Introduction 53 2.2. Materials and Instrumentation 59 2.2.1… …4.1. Multicomponent crystals 93 4.1.1. Results 93 4.1.1.1. Morphology of Novel Salts 93… …Abderhalden’s findings revealed the presence of cystine crystals in the liver and spleen.5 In 1924… …membrane accumulates as crystals in various tissues excluding leucocytes.7,11 Initially, it was… 

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Bahmed, A. (2015). The design and synthesis of novel pro-drugs for the treatment of nephropathic cystinosis. (Doctoral Dissertation). Robert Gordon University. Retrieved from http://hdl.handle.net/10059/1227

Chicago Manual of Style (16th Edition):

Bahmed, Amina. “The design and synthesis of novel pro-drugs for the treatment of nephropathic cystinosis.” 2015. Doctoral Dissertation, Robert Gordon University. Accessed December 04, 2020. http://hdl.handle.net/10059/1227.

MLA Handbook (7th Edition):

Bahmed, Amina. “The design and synthesis of novel pro-drugs for the treatment of nephropathic cystinosis.” 2015. Web. 04 Dec 2020.

Vancouver:

Bahmed A. The design and synthesis of novel pro-drugs for the treatment of nephropathic cystinosis. [Internet] [Doctoral dissertation]. Robert Gordon University; 2015. [cited 2020 Dec 04]. Available from: http://hdl.handle.net/10059/1227.

Council of Science Editors:

Bahmed A. The design and synthesis of novel pro-drugs for the treatment of nephropathic cystinosis. [Doctoral Dissertation]. Robert Gordon University; 2015. Available from: http://hdl.handle.net/10059/1227

.