subject:(Mucosae)

1. Heijden, P.J. Quantitative aspects of immunoglobulin production in the intestine of mice.

Degree: Department of Immunology, 1990, Erasmus University Medical Center

► Most infectious agents enter the body via the mucosae. Therefore, expression of immunological activity at the mucosal surfaces is important as a first line of… (more)

Subjects/Keywords: mucosae; pathogens; mice; mucosal tissues; animal

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Heijden, P. J. (1990). Quantitative aspects of immunoglobulin production in the intestine of mice. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/50847

Chicago Manual of Style (16^th Edition):

Heijden, P J. “Quantitative aspects of immunoglobulin production in the intestine of mice.” 1990. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 13, 2021. http://hdl.handle.net/1765/50847.

MLA Handbook (7^th Edition):

Heijden, P J. “Quantitative aspects of immunoglobulin production in the intestine of mice.” 1990. Web. 13 Apr 2021.

Vancouver:

Heijden PJ. Quantitative aspects of immunoglobulin production in the intestine of mice. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 1990. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/1765/50847.

Council of Science Editors:

Heijden PJ. Quantitative aspects of immunoglobulin production in the intestine of mice. [Doctoral Dissertation]. Erasmus University Medical Center; 1990. Available from: http://hdl.handle.net/1765/50847

2. V. Rainone. ROLE OF THE MUCOSAE-ASSOCIATED EPITHELIAL CHEMOKINE (MEC/CCL28) IN THE MODULATION OF THE IMMUNE RESPONSE AGAINST VIRAL INFECTIONS.

Degree: 2010, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/150210

► Secretory immunity is the main line of defence against mucosal infections as it can provide pathogen blocking secretory IgA at the mucosal surface. CCL28 is… (more)

▼ Secretory immunity is the main line of defence against mucosal infections as it can provide pathogen blocking secretory IgA at the mucosal surface. CCL28 is a chemokine that binds to CCR3 and CCR10 and potently recruits IgA-secreting plasma cells (IgA-ASCs) in the mucosal lamina propria. Virus-like particles (VLPs) are a novel vaccine approach based on non-pathogenic particles that mimic the structure of authentic virus particles. Immunogenicity of vaccines can be improved by the use of chemokine molecular adjuvants. Here we propose experimental strategies for evaluating CCL28 immunomodulatory effects in mice after vaccination with VLPs of HIV-1IIIB, Influenza A virus (H7N1) and HPV-16 for potential future use of the chemokine as an adjuvant in the development of preventive vaccines against mucosal infections. HIV1IIIB-, H7N1- and HPV16-VLPs were produced in collaboration with the Ruhr-Bochum University, the University of Montpellier and the German Research Cancer Centre of Heidelbergh, respectively. Inbred female Balb/c mice were randomized to receive HIV1IIIB-VLPs or H7N1-VLPs or HPV16-VLPs in the presence or absence of the murine CCL28-expressing plasmid on days 0 and 14. Mice were euthanized on day 28. The murine CCL19 expression vector was used as negative control, as this chemokine binds to CCR7 receptor. HIV1IIIB-VLPs, HPV16-VLPs and CCL28- and CCL19-expressing plasmids were administrated intramuscularly; H7N1-VLPs were administrated intraperitoneally. Blood samples and vaginal secretions were collected by standard methods on days 0, 14 and 28. Saliva samples of H7N1-VLPs treated mice were collected on days 0, 14 and 28 after intraperitoneal injection of carbachol to induce mice drooling. Bronchoalveolar lavages were collected on day 28 by insertion into the trachea of a blunt animal-feeding needle and repeated cycles of injection and aspiration of PBS. Tissues obtained from the spleen, colon, lungs and the uterine cervix were collected on day 28 to obtain the lymphocyte-enriched cell population for cell culture assays and to evaluate IgA-plasma cell distribution at the mucosal level by immunohistochemistry analyses. CCR3 and CCR10 surface receptors were evaluated on circulating splenocytes by flow cytometry. Th1- and Th2-type cytokine production was evaluated in the supernatants from cultivated splenocytes and mucosal T-cells after ex vivo re-stimulation with recombinant HIV-1IIIB gp120 or hemagglutinin (HA) from Influenza virus A H7N1 or HPV-1 L1 protein. Antigen-specific IgG and IgA were measured in sera and mucosal secretions by an ELISA method based on recombinant HIV-1IIIB gp120, HA from Influenza A virus H7N1 and HPV-16 L1 protein. Neutralizing activity of both systemic and mucosal antibodies was assessed as well. Finally, CCL28-mediated recruitment of IgA-ASCs at mucosal sites was evaluated by immunohistochemistry analyses of tissues obtained from the mucosa-associated lymphoid tissue (MALT). Results presented herein show a significant increase in the percentage and in the… Advisors/Committee Members: TUTOR: Mario Salvatore Clerici, CO-TUTOR: Daria Lucia Trabattoni, COORDINATORE: Maria Luisa Villa, CLERICI, MARIO SALVATORE, VILLA, MARIA LUISA.

Subjects/Keywords: Mucosae-associated Epithelial Chemokine (MEC/CCL28); Virus-like particles (VLPs); Mucosal immunity; Settore MED/04 - Patologia Generale

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rainone, V. (2010). ROLE OF THE MUCOSAE-ASSOCIATED EPITHELIAL CHEMOKINE (MEC/CCL28) IN THE MODULATION OF THE IMMUNE RESPONSE AGAINST VIRAL INFECTIONS. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/150210

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rainone, V.. “ROLE OF THE MUCOSAE-ASSOCIATED EPITHELIAL CHEMOKINE (MEC/CCL28) IN THE MODULATION OF THE IMMUNE RESPONSE AGAINST VIRAL INFECTIONS.” 2010. Thesis, Università degli Studi di Milano. Accessed April 13, 2021. http://hdl.handle.net/2434/150210.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rainone, V.. “ROLE OF THE MUCOSAE-ASSOCIATED EPITHELIAL CHEMOKINE (MEC/CCL28) IN THE MODULATION OF THE IMMUNE RESPONSE AGAINST VIRAL INFECTIONS.” 2010. Web. 13 Apr 2021.

Vancouver:

Rainone V. ROLE OF THE MUCOSAE-ASSOCIATED EPITHELIAL CHEMOKINE (MEC/CCL28) IN THE MODULATION OF THE IMMUNE RESPONSE AGAINST VIRAL INFECTIONS. [Internet] [Thesis]. Università degli Studi di Milano; 2010. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/2434/150210.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rainone V. ROLE OF THE MUCOSAE-ASSOCIATED EPITHELIAL CHEMOKINE (MEC/CCL28) IN THE MODULATION OF THE IMMUNE RESPONSE AGAINST VIRAL INFECTIONS. [Thesis]. Università degli Studi di Milano; 2010. Available from: http://hdl.handle.net/2434/150210

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Rubbo, Pierre-Alain. Compartimentalisation muqueuse de l’infection par le Virus de l'Immunodéficience Humaine (VIH) et impact de la réponse immunitaire : Mucosal compartmentalization of the Human Immunodeficiency Virus (HIV) infection and impact of the cellular immune response.

Degree: Docteur es, Biologie Santé, 2011, Université Montpellier I

URL: http://www.theses.fr/2011MON1T034

►

Bien que des progrès aient été réalisés dans la lutte contre la transmission du VIH depuis sa découverte il y a bientôt 30 ans, aucun… (more)

▼

Bien que des progrès aient été réalisés dans la lutte contre la transmission du VIH depuis sa découverte il y a bientôt 30 ans, aucun outil thérapeutique actuellement sur le marché ne permet d'éliminer totalement le virus en 2011. Une meilleure connaissance des mécanismes physiopathologiques au niveau des compartiments muqueux, qui sont les principales portes d'entrée de l'infection par le VIH et abritent la majorité des lymphocytes T de l'hôte, est donc indispensable pour espérer éradiquer la pandémie. L'objectif de notre travail a été de caractériser les relations hôte-HIV dans le compartiment pulmonaire et génital ainsi que de décrire la synergie immuno-virologique entre le VIH et le virus herpès simplex (VHS) favorisant la transmission virale.Nous avons observé que les lymphocytes T sont présents en plus faibles proportions dans les sécrétions pulmonaires et génitales que dans le sang et ces cellules ont plus fréquemment un phénotype mémoire et activé. Les lymphocytes T muqueux sont donc plus prompts à sécréter des virus que ceux du sang. L'infection par le VIH est également associée à une dérégulation de la réponse immune muqueuse de l'hôte pouvant favoriser sa réplication. De plus, la modification de l'environnement immunologique liée à la synergie entre le VIH et le VHS apparaît comme un phénomène qui pourrait avoir un impact dans la transmission de chacun des deux virus. Une vision intégrée de la réponse immunitaire muqueuse contre le VIH permettra d'identifier les mécanismes à l'origine de l'infection et de la transmission en tenant compte des spécificités du virus et de l'environnement local ainsi que des interrelations avec le compartiment circulant. Les futurs essais cliniques devront en outre tenir compte des caractéristiques des muqueuses et de l'infection par le VIH afin de développer des thérapies anti-infectieuses avec une efficacité optimale, y compris dans les pays du Sud où les populations sont les principales victimes du VIH.

Although scientific advances have occurred in the fight against HIV transmission since its discovery almost 30 years ago, no current therapeutic tool enables the complete elimination of this virus in 2011. A better understanding of the physiopathological mechanisms at the mucosal compartment levels, which are the main gateways of HIV infection and host the majority of body T lymphocytes, is therefore crucial to bring hopes for eradicating HIV pandemic. The aim of our work is to characterize the host-HIV relationships in the pulmonary and genital compartments as well as the immuno-virological synergy between HIV and the herpes simplex virus (HSV) favouring the viral transmission.We have observed small proportions of T lymphocytes were found in the pulmonary and genital secretions in comparison with blood; and these cells have a more frequent memory and activated phenotype. The mucosal T lymphocytes are therefore quicker to produce viral particles than the blood counterpart. HIV infection is also associated with a deregulation of the host mucosal immune response, which…

Advisors/Committee Members: Van De Perre, Philippe (thesis director).

Subjects/Keywords: Compartimentalisation; Vih; Muqueuses; Interactions virales; Lymphocytes T; Cytokines; Compartimentalization; Hiv; Mucosae; Viral interactions; T lymphocytes; Cytokines

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rubbo, P. (2011). Compartimentalisation muqueuse de l’infection par le Virus de l'Immunodéficience Humaine (VIH) et impact de la réponse immunitaire : Mucosal compartmentalization of the Human Immunodeficiency Virus (HIV) infection and impact of the cellular immune response. (Doctoral Dissertation). Université Montpellier I. Retrieved from http://www.theses.fr/2011MON1T034

Chicago Manual of Style (16^th Edition):

Rubbo, Pierre-Alain. “Compartimentalisation muqueuse de l’infection par le Virus de l'Immunodéficience Humaine (VIH) et impact de la réponse immunitaire : Mucosal compartmentalization of the Human Immunodeficiency Virus (HIV) infection and impact of the cellular immune response.” 2011. Doctoral Dissertation, Université Montpellier I. Accessed April 13, 2021. http://www.theses.fr/2011MON1T034.

MLA Handbook (7^th Edition):

Rubbo, Pierre-Alain. “Compartimentalisation muqueuse de l’infection par le Virus de l'Immunodéficience Humaine (VIH) et impact de la réponse immunitaire : Mucosal compartmentalization of the Human Immunodeficiency Virus (HIV) infection and impact of the cellular immune response.” 2011. Web. 13 Apr 2021.

Vancouver:

Rubbo P. Compartimentalisation muqueuse de l’infection par le Virus de l'Immunodéficience Humaine (VIH) et impact de la réponse immunitaire : Mucosal compartmentalization of the Human Immunodeficiency Virus (HIV) infection and impact of the cellular immune response. [Internet] [Doctoral dissertation]. Université Montpellier I; 2011. [cited 2021 Apr 13]. Available from: http://www.theses.fr/2011MON1T034.

Council of Science Editors:

Rubbo P. Compartimentalisation muqueuse de l’infection par le Virus de l'Immunodéficience Humaine (VIH) et impact de la réponse immunitaire : Mucosal compartmentalization of the Human Immunodeficiency Virus (HIV) infection and impact of the cellular immune response. [Doctoral Dissertation]. Université Montpellier I; 2011. Available from: http://www.theses.fr/2011MON1T034

University of South Africa

4. Steenkamp, Helena Catharina. Riglyne vir 'n terapeutiese begeleidingsprogram vir lyers aan Urbach-Wiethe sindroom .

Degree: 1997, University of South Africa

URL: http://hdl.handle.net/10500/16105

► Urbach-Wiethe Sindroom (beter bekend as lipo"ied prote"inose of hyalinosis cutis et mucosae) is 'n seldsame, outosomaal-oorerflike siekte. Die kenmerkendste simptome van die siekte is vel-… (more)

▼ Urbach-Wiethe Sindroom (beter bekend as lipo"ied prote"inose of hyalinosis cutis et mucosae) is 'n seldsame, outosomaal-oorerflike siekte. Die kenmerkendste simptome van die siekte is vel- en slymvliesveranderinge wat deur 'n neerslag van ekstrasellulere hialienagtige materiaal van onbekende oorsprong veroorsaak word. Die vel word maklik beseer, genees stadig en lelike, pokagtige letsels ontstaan. 'n Fyn, korrelagtige neerslag op die ooglede, die sogenaamde "kralestringvoorkoms" kenmerk die siekte, sowel as heesheid, die prominentste en lastigste simptoom, wat sedert geboorte teenwoordig kan wees. Radiografie en tomografie toon bilaterale,boontjievormige verkalking op die temporale lobbe van die brein, wat tot epileptiese aanvalle en ander neuropsigiese simptome soos geremde geheue en aggressie lei. Heesheid veroorsaak kommunikatiewe beperkinge vir die lyer,terwyldie opsigtelike velletsels aversiewe- en die verkalkings onsigbare beperkinge meebring. Die lyer aan Urbach-Wiethe Sindroom kan volgens die beginsels en kriteria van die medies-kliniese, die persoonsgeorienteerde en die sosio-omgewingsperspektiewe gestremdheid ondervind. Teoreties kan die lyer se belewinge van sy andersheid en die nie-aanvaardingdeurdie gemeenskap, soos by gestremdes,die handhawing van sy selfagting rem, sodat 'n negatiewe selfkonsep tot skuldgevoelens, angsbelewinge en depressie kan lei. 'n Betekenisvolle verband is in die empiriese ondersoek tussen die graad van aantasting en wanaanpassing in die lyer se leefwereld gevind. Die lyers wat ernstig aangetas is, identifiseer moeilik met hulle fisieke voorkoms. ldentiteitsvorming word gerem en die selfagting is negatief. Hulle openbaar 'n negatiewe selfkonsep en depressiewe gevoelens met selfmoordgedagtes. Hulle relasies en sosialisering is problematies en hulle voel hulle word nie deur die gemeenskap aanvaar nie. Die lyers ondervind 'n algemene wanaanpassing in hulle leefwereld. 'n Geval van paranoia is ook gevind. Alhoewel die ouers vrae oor die toestand het en sekere emosies beleef, kan die meeste van hulle die situasie hanteer. Riglyne vir 'n terapeutiese begeleidingsprogram vir lyers aan Urbach-Wiethe Sindroom, wat op die verbetering van die selfkonsep; die hantering van depressie, aggressie en woedebuie, asook die verbetering van relasies en sosialisering gerig is, is saamgestel. 'n Ondersteuningsgroep waarby lyers en hulle ouers kan inskakel, is gestig.; Urbach-Wiethe Syndrome, also known as lipoid proteinosis or hyalinosis cutis et mucosae, is a rare, recessively inherited, autosomal disorder characterized by lesions of the skin and mucosae, caused by widespread deposition of hyaline material of unknown etiology. The skin injures easily and heals slowly with "pock like" lesions. Bead-like deposits on the eyelids, called "string of pearls",are often found. Present since early infancy, hoarseness is the … Advisors/Committee Members: Jacobs, L. J. (Louis Jacobus), 1946- (advisor).

Subjects/Keywords: Urbach-Wiethe Syndrome; Lipoid proteinosis; Lipoidosis cutis et mucosae; Hyalinosis cutis et mucosae; Lipoglyco-proteinosis; Impairment; Handicap; Diability; Chronic illness; Self-concept; Voice disorders

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Steenkamp, H. C. (1997). Riglyne vir 'n terapeutiese begeleidingsprogram vir lyers aan Urbach-Wiethe sindroom . (Doctoral Dissertation). University of South Africa. Retrieved from http://hdl.handle.net/10500/16105

Chicago Manual of Style (16^th Edition):

Steenkamp, Helena Catharina. “Riglyne vir 'n terapeutiese begeleidingsprogram vir lyers aan Urbach-Wiethe sindroom .” 1997. Doctoral Dissertation, University of South Africa. Accessed April 13, 2021. http://hdl.handle.net/10500/16105.

MLA Handbook (7^th Edition):

Steenkamp, Helena Catharina. “Riglyne vir 'n terapeutiese begeleidingsprogram vir lyers aan Urbach-Wiethe sindroom .” 1997. Web. 13 Apr 2021.

Vancouver:

Steenkamp HC. Riglyne vir 'n terapeutiese begeleidingsprogram vir lyers aan Urbach-Wiethe sindroom . [Internet] [Doctoral dissertation]. University of South Africa; 1997. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/10500/16105.

Council of Science Editors:

Steenkamp HC. Riglyne vir 'n terapeutiese begeleidingsprogram vir lyers aan Urbach-Wiethe sindroom . [Doctoral Dissertation]. University of South Africa; 1997. Available from: http://hdl.handle.net/10500/16105

5. Björkman, Eleonora. The Renin Angiotensin System in the Human Esophageal Mucosa − expression, actions and potential involvement in reflux disease.

Degree: 2012, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/30563

► The renin angiotensin system (RAS) is a classical endocrine system, regulating body fluid balance and blood circulation. Recent research has shown that the system is… (more)

▼ The renin angiotensin system (RAS) is a classical endocrine system, regulating body fluid balance and blood circulation. Recent research has shown that the system is being also locally expressed and active in several organs and tissues. Components of RAS have been discovered throughout the gastrointestinal tract and have, in addition, been found in the human esophagus. It was hypothesised that RAS could be of interest in relation to gastroesophageal reflux disease (GERD), which is a prevalent clinical condition, where gastric content backflows into the esophagus and causes troublesome symptoms. The general aim of the present thesis was to confirm the presence and further investigate RAS in healthy and reflux exposed human esophageal mucosae. Esophageal biopsies were collected from healthy volunteers and GERD patients. The gene activity and protein expression of various RAS components were investigated using RT-PCR, western blot, ELISA and immunohistochemistry. The square wave current pulse analysis was investigated for its applicability in Ussing chambers for assessing mucosal epithelial resistance (Rep), which in turn permits calculation of the epithelial ion current (Iep). All investigated RAS components were detected and several of these were significantly altered in relation to reflux disease. Particular attention was paid to the induced expression of the angiotensin II type 2 receptor (AT2R), and to the reduced expression of the angiotensin IV (AngIV) receptor (AT4R) in certain areas in the mucosae from patients with erosive reflux disease (ERD). Using the validated Ussing chamber method, it was found that biopsies from reflux exposed mucosa exhibited lower Rep and higher Iep at baseline. Upon AT2R stimulation the healthy individuals responded with increased Iep, while no significant change was observed in relation to ERD, despite the higher AT2R expression. The peptide AngIV also stimulated the net epithelial current, although the response was small in the mucosae from ERD patients. The thesis demonstrates that a substantial local RAS is present in the human esophageal mucosa, and it is likely that also angiotensins other than Angiotensin II are produced. Particularly, the AT2R, seems to have reduced response capability in individuals with reflux disease. The expressional and functional alterations suggest that RAS might be involved in the pathophysiology of GERD.

Subjects/Keywords: endoscopic biopsies; epithelial electrical current; epithelial electrical resistance; esophageal mucosae; gastroesophageal reflux disease; mucosal barrier integrity; renin angiotensin system

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Björkman, E. (2012). The Renin Angiotensin System in the Human Esophageal Mucosa − expression, actions and potential involvement in reflux disease. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/30563

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Björkman, Eleonora. “The Renin Angiotensin System in the Human Esophageal Mucosa − expression, actions and potential involvement in reflux disease.” 2012. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed April 13, 2021. http://hdl.handle.net/2077/30563.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Björkman, Eleonora. “The Renin Angiotensin System in the Human Esophageal Mucosa − expression, actions and potential involvement in reflux disease.” 2012. Web. 13 Apr 2021.

Vancouver:

Björkman E. The Renin Angiotensin System in the Human Esophageal Mucosa − expression, actions and potential involvement in reflux disease. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2012. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/2077/30563.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Björkman E. The Renin Angiotensin System in the Human Esophageal Mucosa − expression, actions and potential involvement in reflux disease. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2012. Available from: http://hdl.handle.net/2077/30563

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

		in
And / Or
		in
And / Or
		in
And / Or
		in

Open Access Theses and Dissertations