subject:(Motor Excitability)

University of Ontario Institute of Technology

1. Holland, Luc. Cortical adaption influences excitability in the dominant and non-dominant hands following complex novel motor training.

Degree: 2014, University of Ontario Institute of Technology

URL: http://hdl.handle.net/10155/875

► The primary motor cortex (M1) can dynamically control the magnitude of motor refinement through motor plasticity. Plasticity can be investigated by looking at changes to… (more)

▼ The primary motor cortex (M1) can dynamically control the magnitude of motor refinement through motor plasticity. Plasticity can be investigated by looking at changes to motor excitability, which has been established to be stronger in the non-dominant hemisphere of right handed participants. However, it is unclear if these differences in excitability following a training task would still be present if participants performed a task that was equally as difficult for both the dominant and non-dominant hands. Thus, the first goal of this thesis was to develop and validate a novel motor training task designed to be equally challenging for both hands. Participants were required to trace a novel sinusoidal pattern, varying in both amplitude and frequency that was mirrored in both the right and left hand. The time course of learning was plotted over two separate training sessions. The second study then utilized this task to answer the question of which hemisphere has a greater plastic potential, determine by quantifying changes motor excitability, and the time-course over which these changes occur. Motor cortical excitability before and after learning was investigated using recruitment curves which evoke MEPs at 7 different stimulation intensities in order to better capture a more robust measure of hemispheric excitability for both the left and right hand. The training task was indeed novel as it equally challenged both the dominant and non-dominant hands of a healthy right handed population and lead to remarkably similar learning curves over six blocks of learning and similar retention. In the second study, only the dominant hemisphere had significant decreases in excitability following the motor learning task. A secondary study indicated that the time-course over which these changes occurs suggests that when learning a novel training task which the participant is na??ve to, motor training and increases to performance have a rapid onset as changes to excitability were only seen on the first day of training. This may indicate that even though the non-dominant hemisphere has greater initial excitability, the dominant hemisphere has a greater ability to modulate excitability levels showing a greater potential for plastic adaption. Advisors/Committee Members: Yielder, Paul.

Subjects/Keywords: Primary motor cortex; Laterality; Handedness; Motor training; Plasticity; Motor Excitability

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APA (6^th Edition):

Holland, L. (2014). Cortical adaption influences excitability in the dominant and non-dominant hands following complex novel motor training. (Thesis). University of Ontario Institute of Technology. Retrieved from http://hdl.handle.net/10155/875

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Holland, Luc. “Cortical adaption influences excitability in the dominant and non-dominant hands following complex novel motor training.” 2014. Thesis, University of Ontario Institute of Technology. Accessed March 05, 2021. http://hdl.handle.net/10155/875.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Holland, Luc. “Cortical adaption influences excitability in the dominant and non-dominant hands following complex novel motor training.” 2014. Web. 05 Mar 2021.

Vancouver:

Holland L. Cortical adaption influences excitability in the dominant and non-dominant hands following complex novel motor training. [Internet] [Thesis]. University of Ontario Institute of Technology; 2014. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10155/875.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Holland L. Cortical adaption influences excitability in the dominant and non-dominant hands following complex novel motor training. [Thesis]. University of Ontario Institute of Technology; 2014. Available from: http://hdl.handle.net/10155/875

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

2. Toepp, Stephen. Investigating the Effects of Glucose and Sweet Taste on Corticospinal and Intracortical Excitability.

Degree: MSc, 2019, McMaster University

URL: http://hdl.handle.net/11375/24872

►

Transcranial magnetic stimulation (TMS) is commonly used to measure corticospinal and intracortical excitability in basic and clinical neuroscience. However, the effect of glucose on TMS-based… (more)

▼

Transcranial magnetic stimulation (TMS) is commonly used to measure corticospinal and intracortical excitability in basic and clinical neuroscience. However, the effect of glucose on TMS-based measures is not well defined, despite a potentially impactful influence on precision and reliability. Here, a double-blinded placebo-controlled study was used to test the effects of glucose on two commonly used TMS measures: short-interval intracortical inhibition (SICI), and the area under the motor evoked potential recruitment curves (AURC). SICI and AURC are thought to reflect inhibitory (GABAergic) and excitatory (glutamatergic) neurotransmission respectively. Healthy males (N=18) each participated in four sessions. Session 1 involved TMS familiarization and acquisition of an individualized blood glucose response curve. During sessions 2, 3 and 4, dependent measures were taken before (T0) and twice after (T1 & T2) drinking 300 mL of solution containing glucose (75 g), sucralose-sweetened placebo (control for sweetness) or plain water (control for time). The T1 and T2 measurements were started 5 minutes prior to the blood glucose peak observed during Session 1. Blood glucose and mean arterial pressure (MAP) were also monitored. Sucralose, but not water or glucose increased AURC and none of the treatments altered SICI. There was no association between blood glucose level and TMS measures, but in all three conditions MAP rose after consumption of the drink. There was a positive correlation between the rise in blood pressure and the relative increase in AURC at the higher stimulus intensities. Eleven participants returned for a fifth session to quantify the smallest detectible change in the AURC measurements and it was confirmed that significant changes were real while non-significant differences in measurement means fell within the range of expected measurement error. This study also suggests a relationship between corticospinal excitability and autonomic tone. Additional investigation is required to understand the mediating factors of this association.

Thesis

Master of Science (MSc)

Advisors/Committee Members: Nelson, Aimee, Kinesiology.

Subjects/Keywords: glucose; transcranial magnetic stimulation; blood pressure; corticospinal excitability; intracortical excitability; Primary Motor Cortex

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APA (6^th Edition):

Toepp, S. (2019). Investigating the Effects of Glucose and Sweet Taste on Corticospinal and Intracortical Excitability. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/24872

Chicago Manual of Style (16^th Edition):

Toepp, Stephen. “Investigating the Effects of Glucose and Sweet Taste on Corticospinal and Intracortical Excitability.” 2019. Masters Thesis, McMaster University. Accessed March 05, 2021. http://hdl.handle.net/11375/24872.

MLA Handbook (7^th Edition):

Toepp, Stephen. “Investigating the Effects of Glucose and Sweet Taste on Corticospinal and Intracortical Excitability.” 2019. Web. 05 Mar 2021.

Vancouver:

Toepp S. Investigating the Effects of Glucose and Sweet Taste on Corticospinal and Intracortical Excitability. [Internet] [Masters thesis]. McMaster University; 2019. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/11375/24872.

Council of Science Editors:

Toepp S. Investigating the Effects of Glucose and Sweet Taste on Corticospinal and Intracortical Excitability. [Masters Thesis]. McMaster University; 2019. Available from: http://hdl.handle.net/11375/24872

Wilfrid Laurier University

3. Cinelli, Kezia. The task at hand: fatigue-associated changes to corticospinal excitability during writing.

Degree: 2019, Wilfrid Laurier University

URL: https://scholars.wlu.ca/etd/2190

► Corticospinal excitability as measured via transcranial magnetic stimulation (TMS) is highly dependent on the task being performed at the time of stimulation. As such, this… (more)

▼ Corticospinal excitability as measured via transcranial magnetic stimulation (TMS) is highly dependent on the task being performed at the time of stimulation. As such, this study sought out to measure corticospinal excitability during the relevant, daily task of writing and compare it to the conventional abduction task often utilized. We used single-pulse motor evoked potentials (MEPs) to provide a measure of corticospinal excitability and cortical silent period (CSP) duration, and paired-pulse conditioned MEPs to assess short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) recorded from the right first dorsal interosseous (FDI) of 19 participants on two randomized and counter-balanced days. On one day, participants performed the writing task, which consisted of writing the word name on a graphic tablet whose screen refreshed every 5-seconds. On the other day, the abduction task was performed and consisted of participants isometrically abducting their right index finger at a level that matched EMG levels during writing. Each day consisted of a pre-fatigue test where participants performed the designated task and corticospinal excitability was measured, a fatiguing task, and a post-fatigue test which was identical to the pre-fatigue test. There was a main effect of task on SICI, such that we saw greater inhibition during writing (F=4.91, [1,16], p=0.04). The writing task was further broken down into a printing task and a cursive writing task based on participant’s self-selected writing styles. Accordingly, we compared fatigue-induced changes in CSE in printers (n=8) and cursive writers (n=8). Following fatigue, ICF increased (35%±46%) in the printers but did not change in the cursive writing group (5%±13%). This study is the first to assess measures of corticospinal excitability during a handwriting task. Given that changes in intracortical excitability after a fatigue protocol depend on the motor task used to assess excitability, future studies should use paradigms that mimic functionally relevant motor tasks to better understand the role that CSE may play in the neural control of movement.

Subjects/Keywords: TMS; task-dependent; fatigue; corticospinal excitability; motor control; Motor Control; Physiology

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APA (6^th Edition):

Cinelli, K. (2019). The task at hand: fatigue-associated changes to corticospinal excitability during writing. (Thesis). Wilfrid Laurier University. Retrieved from https://scholars.wlu.ca/etd/2190

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cinelli, Kezia. “The task at hand: fatigue-associated changes to corticospinal excitability during writing.” 2019. Thesis, Wilfrid Laurier University. Accessed March 05, 2021. https://scholars.wlu.ca/etd/2190.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cinelli, Kezia. “The task at hand: fatigue-associated changes to corticospinal excitability during writing.” 2019. Web. 05 Mar 2021.

Vancouver:

Cinelli K. The task at hand: fatigue-associated changes to corticospinal excitability during writing. [Internet] [Thesis]. Wilfrid Laurier University; 2019. [cited 2021 Mar 05]. Available from: https://scholars.wlu.ca/etd/2190.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cinelli K. The task at hand: fatigue-associated changes to corticospinal excitability during writing. [Thesis]. Wilfrid Laurier University; 2019. Available from: https://scholars.wlu.ca/etd/2190

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brunel University

4. D'Innocenzo, Giorgia. The relationship between gaze and information pickup during action observation : implications for motor skill (re)learning.

Degree: PhD, 2018, Brunel University

URL: http://bura.brunel.ac.uk/handle/2438/16354 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.764987

► The aim of the present thesis was to investigate the relationship between individuals' allocation of overt visual attention during action observation and their consequent pickup… (more)

▼ The aim of the present thesis was to investigate the relationship between individuals' allocation of overt visual attention during action observation and their consequent pickup of information. Four interrelated studies were conducted to achieve this. In Study 1 we examined the effects of visual guidance - colour highlighting of relevant aspects of the action - on observational learning of the golf swing. The results showed that the visual guides facilitated novices' intake of information pertaining to the model's posture, which was reflected in faster learning. In the remaining studies, transcranial magnetic stimulation and eye tracking data were acquired concurrently to measure the interaction between gaze behaviour and motor resonance - a neurophysiological index of the motor system's engagement with a viewed action, and thus a correlate of information extraction. In Study 2, we directed observers' gaze to distinct locations of the display while they viewed thumb adduction/abduction movements. The results showed that, by directing gaze to a location that maximised the amount of thumb motion across the fovea, motor resonance was maximised relative to a free viewing condition. In Study 3 we examined the link between gaze and motor resonance during the observation of transitive actions. Participants viewed reach-to-grasp actions with natural gaze, or while looking at a target- or an effector- based visual guide. The results showed that the effector-based guide disrupted natural gaze behaviour, and this was associated with a reversal of the motor resonance response. In Study 4 we showed novice and skilled golfers videos of the golf swing and of a reach-grasp-lift action. The results revealed that, for both actions, the extent of motor resonance was related to the location of participants' fixations. The present work provides the first evidence of a relationship between gaze and motor resonance and highlights the importance of appropriate gaze behaviour for observational learning.

Subjects/Keywords: 612.8; Skill acquisition; Motor resonance; Corticospinal excitability; Motor learning; Eye tracking

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APA (6^th Edition):

D'Innocenzo, G. (2018). The relationship between gaze and information pickup during action observation : implications for motor skill (re)learning. (Doctoral Dissertation). Brunel University. Retrieved from http://bura.brunel.ac.uk/handle/2438/16354 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.764987

Chicago Manual of Style (16^th Edition):

D'Innocenzo, Giorgia. “The relationship between gaze and information pickup during action observation : implications for motor skill (re)learning.” 2018. Doctoral Dissertation, Brunel University. Accessed March 05, 2021. http://bura.brunel.ac.uk/handle/2438/16354 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.764987.

MLA Handbook (7^th Edition):

D'Innocenzo, Giorgia. “The relationship between gaze and information pickup during action observation : implications for motor skill (re)learning.” 2018. Web. 05 Mar 2021.

Vancouver:

D'Innocenzo G. The relationship between gaze and information pickup during action observation : implications for motor skill (re)learning. [Internet] [Doctoral dissertation]. Brunel University; 2018. [cited 2021 Mar 05]. Available from: http://bura.brunel.ac.uk/handle/2438/16354 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.764987.

Council of Science Editors:

D'Innocenzo G. The relationship between gaze and information pickup during action observation : implications for motor skill (re)learning. [Doctoral Dissertation]. Brunel University; 2018. Available from: http://bura.brunel.ac.uk/handle/2438/16354 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.764987

Université Catholique de Louvain

5. Grandjean, Julien. Using a new double-coil TMS method to study vulnerability markers in addictions.

Degree: 2020, Université Catholique de Louvain

URL: http://hdl.handle.net/2078.1/235674

►

The present thesis is articulated around three main axes. The first one focuses on assessing whether it is possible to obtain reliable motor-evoked potentials in… (more)

Subjects/Keywords: Transcranial Magnetic Stimulation; Neurosciences; Addictions; Motor-evoked potentials; Corticospinal excitability; Motor cortex; Primary motor cortex

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APA (6^th Edition):

Grandjean, J. (2020). Using a new double-coil TMS method to study vulnerability markers in addictions. (Thesis). Université Catholique de Louvain. Retrieved from http://hdl.handle.net/2078.1/235674

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Grandjean, Julien. “Using a new double-coil TMS method to study vulnerability markers in addictions.” 2020. Thesis, Université Catholique de Louvain. Accessed March 05, 2021. http://hdl.handle.net/2078.1/235674.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Grandjean, Julien. “Using a new double-coil TMS method to study vulnerability markers in addictions.” 2020. Web. 05 Mar 2021.

Vancouver:

Grandjean J. Using a new double-coil TMS method to study vulnerability markers in addictions. [Internet] [Thesis]. Université Catholique de Louvain; 2020. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/2078.1/235674.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Grandjean J. Using a new double-coil TMS method to study vulnerability markers in addictions. [Thesis]. Université Catholique de Louvain; 2020. Available from: http://hdl.handle.net/2078.1/235674

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

6. Hindle, Alyssa R. A comparison of neuromuscular electrical stimulation parameters on increasing corticospinal excitability.

Degree: MS, Centre for Neuroscience Physical Education and Recreation, 2013, University of Alberta

URL: https://era.library.ualberta.ca/files/d504rk378

► In this thesis, experiments that investigated the effects of neuromuscular electrical stimulation (NMES) parameters on corticospinal (CS) excitability are described. The NMES-induced afferent volley can… (more)

Subjects/Keywords: Corticospinal excitability; Stimulation parameters; Motor cortex; Neuromuscular electrical stimulation

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APA (6^th Edition):

Hindle, A. R. (2013). A comparison of neuromuscular electrical stimulation parameters on increasing corticospinal excitability. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/d504rk378

Chicago Manual of Style (16^th Edition):

Hindle, Alyssa R. “A comparison of neuromuscular electrical stimulation parameters on increasing corticospinal excitability.” 2013. Masters Thesis, University of Alberta. Accessed March 05, 2021. https://era.library.ualberta.ca/files/d504rk378.

MLA Handbook (7^th Edition):

Hindle, Alyssa R. “A comparison of neuromuscular electrical stimulation parameters on increasing corticospinal excitability.” 2013. Web. 05 Mar 2021.

Vancouver:

Hindle AR. A comparison of neuromuscular electrical stimulation parameters on increasing corticospinal excitability. [Internet] [Masters thesis]. University of Alberta; 2013. [cited 2021 Mar 05]. Available from: https://era.library.ualberta.ca/files/d504rk378.

Council of Science Editors:

Hindle AR. A comparison of neuromuscular electrical stimulation parameters on increasing corticospinal excitability. [Masters Thesis]. University of Alberta; 2013. Available from: https://era.library.ualberta.ca/files/d504rk378

University of Guelph

7. Jegatheeswaran, Gaayathiri. The Effects of Central Sensitization on Motoneurone Excitability in Osteoarthritis.

Degree: MS, Department of Human Health and Nutritional Sciences, 2012, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3620

► This thesis is an investigation of the neurophysiologic mechanism, central sensitization, underlying pain and dysfunction in osteoarthritis. Central sensitization is an important mechanism in the… (more)

Subjects/Keywords: central sensitization; osteoarthritis; electromyography; motor units; capsaicin; motoneurone excitability

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APA (6^th Edition):

Jegatheeswaran, G. (2012). The Effects of Central Sensitization on Motoneurone Excitability in Osteoarthritis. (Masters Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3620

Chicago Manual of Style (16^th Edition):

Jegatheeswaran, Gaayathiri. “The Effects of Central Sensitization on Motoneurone Excitability in Osteoarthritis.” 2012. Masters Thesis, University of Guelph. Accessed March 05, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3620.

MLA Handbook (7^th Edition):

Jegatheeswaran, Gaayathiri. “The Effects of Central Sensitization on Motoneurone Excitability in Osteoarthritis.” 2012. Web. 05 Mar 2021.

Vancouver:

Jegatheeswaran G. The Effects of Central Sensitization on Motoneurone Excitability in Osteoarthritis. [Internet] [Masters thesis]. University of Guelph; 2012. [cited 2021 Mar 05]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3620.

Council of Science Editors:

Jegatheeswaran G. The Effects of Central Sensitization on Motoneurone Excitability in Osteoarthritis. [Masters Thesis]. University of Guelph; 2012. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3620

University of Connecticut

8. Rush, Justin L. The Effects of Transcranial Direct Current Stimulation on Quadriceps Muscle Function in Individuals with a History of Anterior Cruciate Ligament Reconstruction.

Degree: MS, Kinesiology, 2019, University of Connecticut

URL: https://opencommons.uconn.edu/gs_theses/1380

► Context: Altered quadriceps activation is common following anterior cruciate ligament reconstruction (ACLR), and can persist for years after surgery. These neural deficits are partially… (more)

Subjects/Keywords: Motor cortex excitability; transcranial direct current stimulation; anterior cruciate ligament

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APA (6^th Edition):

Rush, J. L. (2019). The Effects of Transcranial Direct Current Stimulation on Quadriceps Muscle Function in Individuals with a History of Anterior Cruciate Ligament Reconstruction. (Masters Thesis). University of Connecticut. Retrieved from https://opencommons.uconn.edu/gs_theses/1380

Chicago Manual of Style (16^th Edition):

Rush, Justin L. “The Effects of Transcranial Direct Current Stimulation on Quadriceps Muscle Function in Individuals with a History of Anterior Cruciate Ligament Reconstruction.” 2019. Masters Thesis, University of Connecticut. Accessed March 05, 2021. https://opencommons.uconn.edu/gs_theses/1380.

MLA Handbook (7^th Edition):

Rush, Justin L. “The Effects of Transcranial Direct Current Stimulation on Quadriceps Muscle Function in Individuals with a History of Anterior Cruciate Ligament Reconstruction.” 2019. Web. 05 Mar 2021.

Vancouver:

Rush JL. The Effects of Transcranial Direct Current Stimulation on Quadriceps Muscle Function in Individuals with a History of Anterior Cruciate Ligament Reconstruction. [Internet] [Masters thesis]. University of Connecticut; 2019. [cited 2021 Mar 05]. Available from: https://opencommons.uconn.edu/gs_theses/1380.

Council of Science Editors:

Rush JL. The Effects of Transcranial Direct Current Stimulation on Quadriceps Muscle Function in Individuals with a History of Anterior Cruciate Ligament Reconstruction. [Masters Thesis]. University of Connecticut; 2019. Available from: https://opencommons.uconn.edu/gs_theses/1380

New Jersey Institute of Technology

9. Salloum, Dalia. Regulation of voltage-gated K+ currents in motor neurons: activity-dependence and neuromodulation.

Degree: PhD, Federated Department of Biological Sciences, 2017, New Jersey Institute of Technology

URL: https://digitalcommons.njit.edu/dissertations/5

► Neuronal output is shaped by extrinsic modulation as well as modulation of intrinsic properties of individual neurons, mediated by activity-dependent changes in the expression… (more)

▼ Neuronal output is shaped by extrinsic modulation as well as modulation of intrinsic properties of individual neurons, mediated by activity-dependent changes in the expression levels of voltage-gated ionic currents. Activity-dependent regulation of ionic currents is a mechanism by which electrical output of a neuron feeds back onto the expression of its own ion channels to alter cellular excitability in response to stimuli. Neurons alter their intrinsic properties to achieve long lasting changes involved in development, learning and memory formation and vital functions of organ systems such as locomotion and digestion. At the same time, plasticity of neuronal excitability driven by previous experience requires mechanisms to promote stability to maintain physiological function, and many examples of this type of homeostatic plasticity changes have been reported. At the same time, neuromodulation can alter electrical output indirectly via ligand-gated receptors and second messenger pathways and potentially affect activity-dependent effects. Activity-dependent regulation of ionic currents functions to allow neurons to track their own electrical activity and adjust their intrinsic properties in response to changing synaptic drive or other inputs to maintain their functional output. This phenomenon has been demonstrated to occur over the course of minutes and is a relatively fast process. Neuromodulators exert long-term effects on ionic currents via activation of cellular signaling pathways that do not directly affect ionic current levels. Neuromodulation and activity-dependent effects can alter neuronal networks on different time scales, e.g. over several hours to days to accommodate the needs of the behaving organism such as in transitions between sleep and waking states. However, this is not necessarily so, and the possibility of real-time interactions exist and needs to be examined. Advisors/Committee Members: Jorge P. Golowasch, Farzan Nadim, Eric Scott Fortune.

Subjects/Keywords: Neuronal excitability; Neuromodulation; K+ channels; Motor neurons; CPG; Activity dependent; Biology

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APA (6^th Edition):

Salloum, D. (2017). Regulation of voltage-gated K+ currents in motor neurons: activity-dependence and neuromodulation. (Doctoral Dissertation). New Jersey Institute of Technology. Retrieved from https://digitalcommons.njit.edu/dissertations/5

Chicago Manual of Style (16^th Edition):

Salloum, Dalia. “Regulation of voltage-gated K+ currents in motor neurons: activity-dependence and neuromodulation.” 2017. Doctoral Dissertation, New Jersey Institute of Technology. Accessed March 05, 2021. https://digitalcommons.njit.edu/dissertations/5.

MLA Handbook (7^th Edition):

Salloum, Dalia. “Regulation of voltage-gated K+ currents in motor neurons: activity-dependence and neuromodulation.” 2017. Web. 05 Mar 2021.

Vancouver:

Salloum D. Regulation of voltage-gated K+ currents in motor neurons: activity-dependence and neuromodulation. [Internet] [Doctoral dissertation]. New Jersey Institute of Technology; 2017. [cited 2021 Mar 05]. Available from: https://digitalcommons.njit.edu/dissertations/5.

Council of Science Editors:

Salloum D. Regulation of voltage-gated K+ currents in motor neurons: activity-dependence and neuromodulation. [Doctoral Dissertation]. New Jersey Institute of Technology; 2017. Available from: https://digitalcommons.njit.edu/dissertations/5

University of Arizona

10. Schaefer, Jennifer. INTRINSIC PROPERTIES OF LARVAL DROSOPHILA MOTONEURONS AND THEIR CONTRIBUTION TO MOTONEURON RECRUITMENT AND FIRING BEHAVIOR DURING FICTIVE LOCOMOTION .

Degree: 2010, University of Arizona

URL: http://hdl.handle.net/10150/194655

► Locomotion is controlled in large part by neural circuits (CPGs) that generate rhythmic stereotyped outputs in the absence of descending or sensory inputs. The output… (more)

▼ Locomotion is controlled in large part by neural circuits (CPGs) that generate rhythmic stereotyped outputs in the absence of descending or sensory inputs. The output of a neural circuit is determined by the configuration of the circuit, synapse properties, and the intrinsic properties of component neurons. In order to understand how a neural circuit functions component neurons, their connections, and their intrinsic properties must be characterized. Motoneurons are a useful cell in which to begin investigation of CPG function because they are accessible and provide a measure of the cumulative activity of the circuit. Drosophila is a potentially useful model system for the study of motoneuron intrinsic properties, their contribution to locomotion, and of locomotor CPGs because the genetic and molecular techniques available in Drosophila are surpassed in no other organism and because the Drosophila nervous system is small in comparison to vertebrate nervous systems. Further, whole-cell in situ patch clamp recordings from adult and larval motoneurons in relatively intact preparations are possible. Therefore, the first goal of this work was to investigate whether the firing behavior and recruitment of identified Drosophila 1b and 1s motoneurons is analogous to the recruitment of high-threshold, phasic and low-threshold, tonic motoneurons in other organisms. The second goal was to determine whether active conductances influence motoneuron recruitment in response to synaptic input. The final aim was to investigate how these factors influence CPG output to muscles. Findings from current clamp studies indicate that1b motoneurons are more easily recruited than 1s motoneurons, in agreement with the hypothesis that 1b motoneurons are analogous to low-threshold motoneurons described in other organisms. Further, orderly recruitment of Drosophila 1b motoneurons before 1s motoneurons is not a result of passive properties. Instead, the Shal channel that encodes a large portion of IA in motoneuron somatodendritic regions is a critical determinant of delay-to-spike in larval Drosophila motoneurons. These findings are behaviorally-relevant because the same recruitment order is seen in simultaneous recordings from motoneuron pairs recruited by synaptic input. Advisors/Committee Members: Levine, Richard B (advisor), Duch, Carsten (committeemember), Fregosi, Ralph (committeemember), Fuglevand, Andrew (committeemember), Rankin, Lucinda (committeemember).

Subjects/Keywords: Drosophila; excitability; motor neuron; recruitment

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APA (6^th Edition):

Schaefer, J. (2010). INTRINSIC PROPERTIES OF LARVAL DROSOPHILA MOTONEURONS AND THEIR CONTRIBUTION TO MOTONEURON RECRUITMENT AND FIRING BEHAVIOR DURING FICTIVE LOCOMOTION . (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/194655

Chicago Manual of Style (16^th Edition):

Schaefer, Jennifer. “INTRINSIC PROPERTIES OF LARVAL DROSOPHILA MOTONEURONS AND THEIR CONTRIBUTION TO MOTONEURON RECRUITMENT AND FIRING BEHAVIOR DURING FICTIVE LOCOMOTION .” 2010. Doctoral Dissertation, University of Arizona. Accessed March 05, 2021. http://hdl.handle.net/10150/194655.

MLA Handbook (7^th Edition):

Schaefer, Jennifer. “INTRINSIC PROPERTIES OF LARVAL DROSOPHILA MOTONEURONS AND THEIR CONTRIBUTION TO MOTONEURON RECRUITMENT AND FIRING BEHAVIOR DURING FICTIVE LOCOMOTION .” 2010. Web. 05 Mar 2021.

Vancouver:

Schaefer J. INTRINSIC PROPERTIES OF LARVAL DROSOPHILA MOTONEURONS AND THEIR CONTRIBUTION TO MOTONEURON RECRUITMENT AND FIRING BEHAVIOR DURING FICTIVE LOCOMOTION . [Internet] [Doctoral dissertation]. University of Arizona; 2010. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10150/194655.

Council of Science Editors:

Schaefer J. INTRINSIC PROPERTIES OF LARVAL DROSOPHILA MOTONEURONS AND THEIR CONTRIBUTION TO MOTONEURON RECRUITMENT AND FIRING BEHAVIOR DURING FICTIVE LOCOMOTION . [Doctoral Dissertation]. University of Arizona; 2010. Available from: http://hdl.handle.net/10150/194655

University of Waterloo

11. Ibey, Robyn. Factors influencing bilateral interactions in the human motor cortex: investigating transcallosal sensorimotor networks.

Degree: 2017, University of Waterloo

URL: http://hdl.handle.net/10012/11836

► All daily activities require the precise interaction and coordination of several brain regions to facilitate purposeful movements of the upper limbs. The mechanisms responsible for… (more)

Subjects/Keywords: Primary Motor Cortex; Cross Excitability; Contraction; Transcranial Magnetic Stimulation; Interhemispheric Interactions

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ibey, R. (2017). Factors influencing bilateral interactions in the human motor cortex: investigating transcallosal sensorimotor networks. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/11836

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ibey, Robyn. “Factors influencing bilateral interactions in the human motor cortex: investigating transcallosal sensorimotor networks.” 2017. Thesis, University of Waterloo. Accessed March 05, 2021. http://hdl.handle.net/10012/11836.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ibey, Robyn. “Factors influencing bilateral interactions in the human motor cortex: investigating transcallosal sensorimotor networks.” 2017. Web. 05 Mar 2021.

Vancouver:

Ibey R. Factors influencing bilateral interactions in the human motor cortex: investigating transcallosal sensorimotor networks. [Internet] [Thesis]. University of Waterloo; 2017. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10012/11836.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ibey R. Factors influencing bilateral interactions in the human motor cortex: investigating transcallosal sensorimotor networks. [Thesis]. University of Waterloo; 2017. Available from: http://hdl.handle.net/10012/11836

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Univerzitet u Beogradu

12. Jelić, Milan B., 1985-. Uticaj neinvazivne neuromodulacije motornog korteksa na motorno učenje.

Degree: Fakultet sporta i fizičkog vaspitanja, 2015, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:6682/bdef:Content/get

►

Fizičko vaspitanje i sport - Opšta motorika čoveka / Physical Education and Sport - Human Kinesiology

Cilj rada: Cilj istraživanja je ispitivanje uloge primarnog motornog… (more)

▼

Fizičko vaspitanje i sport - Opšta motorika čoveka / Physical Education and Sport - Human Kinesiology

Cilj rada: Cilj istraživanja je ispitivanje uloge primarnog motornog korteksa (M1) u motornom učenju. Radi ostvarivanja ovog cilja evaluirani su efekti nekoliko različitih metoda i protokola neinvizivne neuromodulacije pomoću transkranijalne magnetne stimulacije (TMS) primenjenih na M1 oblast. Namera je bila da se pokaže da li, kako i koliko pojedini protokoli TMS-a putem izazivanja promena ekscitabilnosti M1 ubrzavaju ili usporavaju motorno učenje. Metode: Ukupno je učestvovalo 84 zdrava desnoruka ispitanika starosti 26 ± 3 godine (46 M i 38 Ž). U svim eksperimentima TMS se aplikovao pomoću „Magstim Rapid“ stimulatora (Magstim Ltd) sa kalemom u obliku broja osam i krilima prečnika 70mm. Elektromiografski signal je registrovan pomoću površinskih elektroda, sa prvog dorzalnog interosalnog mišića (1DI). Kao mera ekscitabilnosti M1 korišćena je amplituda motornih evociranih potencijala (MEP), izazvanih pojedinačnim stimulusima TMS-a iznad reprezentacije 1DI-a. Za procenu motornog učenja korišćeni su rezultati na jednom jednostavanom zadataku - vreme reakcije na zvučni signal (VR), i jednom složenom zadataku - purdue pegboard test (PPT). Na VR zadatku ispitanici su izvodili 10 brzih, jakih i kratkotrajnih kontrakcija 1DI mišića, kao reakciju na zvučni signal, a na PPT-u se merio broj postavljenih klinova u niz rupica na posebno dizajniranoj tabli tokom 30s. Primenjivano je nekoliko različitih metoda neinvazivne neuromodulacije TMS-om sa različitim fiziološkim efektima: 10Hz repetitivna TMS (rTMS) i intermitentna stimulacija teta nizovima (intermitentna “Theta burst” stimulacija – iTBS) za koje se očekivalo da dovedu do povišenja eskcitabilnosti, i nasuprot njima kontinuirana “Theta burst” stimulacija – cTBS za koju se očekivalo da dovede do snižavanja ekscitabilnosti. Koja od ovih metoda je korišćena kao eksperimentalna intervencija zavisilo je od eksperimenta, ali se uvek primenjivala u vidu stvarne ili placebo (lažne) TMS intervencije, s tim što ispitanik nije znao koju od ove dve intervencije je dobijao. Merenje amplituda MEP-a i izvođenje VR-a i PPT-a obavljano je pre intervencije, odmah posle intervencije i 30 minuta nakon intervencije...

Advisors/Committee Members: Filipović, Saša.

Subjects/Keywords: motor learning; transcranial magnetic stimulation; primary motor cortex; purdue pegboard; reaction time; excitability; plasticity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jelić, Milan B., 1. (2015). Uticaj neinvazivne neuromodulacije motornog korteksa na motorno učenje. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:6682/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jelić, Milan B., 1985-. “Uticaj neinvazivne neuromodulacije motornog korteksa na motorno učenje.” 2015. Thesis, Univerzitet u Beogradu. Accessed March 05, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:6682/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jelić, Milan B., 1985-. “Uticaj neinvazivne neuromodulacije motornog korteksa na motorno učenje.” 2015. Web. 05 Mar 2021.

Vancouver:

Jelić, Milan B. 1. Uticaj neinvazivne neuromodulacije motornog korteksa na motorno učenje. [Internet] [Thesis]. Univerzitet u Beogradu; 2015. [cited 2021 Mar 05]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:6682/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jelić, Milan B. 1. Uticaj neinvazivne neuromodulacije motornog korteksa na motorno učenje. [Thesis]. Univerzitet u Beogradu; 2015. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:6682/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Tasmania

13. Thorpe, ML. Effect of a drawing task on cortical excitability.

Degree: 2014, University of Tasmania

URL: https://eprints.utas.edu.au/22589/1/2014HonoursThesis_mt.pdf

► The present study examined the effects of a well-practiced motor skill on measures of primary motor cortex (M1) and corticospinal activity in a small sample… (more)

Subjects/Keywords: 320000 Medical and Health Sciences; primary motor cortex motor cortex cortical excitability baseline excitability hand function hand muscles drawing task symbol copying task stroke rehabilitation cohort study transcranial magnetic stimulation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Thorpe, M. (2014). Effect of a drawing task on cortical excitability. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/22589/1/2014HonoursThesis_mt.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Thorpe, ML. “Effect of a drawing task on cortical excitability.” 2014. Thesis, University of Tasmania. Accessed March 05, 2021. https://eprints.utas.edu.au/22589/1/2014HonoursThesis_mt.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Thorpe, ML. “Effect of a drawing task on cortical excitability.” 2014. Web. 05 Mar 2021.

Vancouver:

Thorpe M. Effect of a drawing task on cortical excitability. [Internet] [Thesis]. University of Tasmania; 2014. [cited 2021 Mar 05]. Available from: https://eprints.utas.edu.au/22589/1/2014HonoursThesis_mt.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Thorpe M. Effect of a drawing task on cortical excitability. [Thesis]. University of Tasmania; 2014. Available from: https://eprints.utas.edu.au/22589/1/2014HonoursThesis_mt.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

14. Mang, Cameron Scott. Changes in corticospinal excitability induced by neuromuscular electrical stimulation.

Degree: MS, Physical Education and Recreation, 2010, University of Alberta

URL: https://era.library.ualberta.ca/files/8910jt74h

► This thesis describes experiments designed to investigate the effects of neuromuscular electrical stimulation (NMES) on corticospinal (CS) excitability in humans. NMES delivered at 100 Hz… (more)

Subjects/Keywords: motor cortex; corticospinal excitability; neuromuscular electrical stimulation; stimulation frequency; transcranial magnetic stimulation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mang, C. S. (2010). Changes in corticospinal excitability induced by neuromuscular electrical stimulation. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/8910jt74h

Chicago Manual of Style (16^th Edition):

Mang, Cameron Scott. “Changes in corticospinal excitability induced by neuromuscular electrical stimulation.” 2010. Masters Thesis, University of Alberta. Accessed March 05, 2021. https://era.library.ualberta.ca/files/8910jt74h.

MLA Handbook (7^th Edition):

Mang, Cameron Scott. “Changes in corticospinal excitability induced by neuromuscular electrical stimulation.” 2010. Web. 05 Mar 2021.

Vancouver:

Mang CS. Changes in corticospinal excitability induced by neuromuscular electrical stimulation. [Internet] [Masters thesis]. University of Alberta; 2010. [cited 2021 Mar 05]. Available from: https://era.library.ualberta.ca/files/8910jt74h.

Council of Science Editors:

Mang CS. Changes in corticospinal excitability induced by neuromuscular electrical stimulation. [Masters Thesis]. University of Alberta; 2010. Available from: https://era.library.ualberta.ca/files/8910jt74h

University of Ottawa

15. Kennefick, Michael. Time Course of Corticospinal Excitability in Simple Reaction Time Tasks .

Degree: 2014, University of Ottawa

URL: http://hdl.handle.net/10393/31504

► The process of movement execution can be separated into two sections; the foreperiod and the response time. The foreperiod represents the time between the warning… (more)

Subjects/Keywords: Transcranial Magnetic Stimulation; Corticospinal Excitability; Motor Preparation; Simple Reaction Time Task; Time Course; Complexity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kennefick, M. (2014). Time Course of Corticospinal Excitability in Simple Reaction Time Tasks . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/31504

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kennefick, Michael. “Time Course of Corticospinal Excitability in Simple Reaction Time Tasks .” 2014. Thesis, University of Ottawa. Accessed March 05, 2021. http://hdl.handle.net/10393/31504.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kennefick, Michael. “Time Course of Corticospinal Excitability in Simple Reaction Time Tasks .” 2014. Web. 05 Mar 2021.

Vancouver:

Kennefick M. Time Course of Corticospinal Excitability in Simple Reaction Time Tasks . [Internet] [Thesis]. University of Ottawa; 2014. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10393/31504.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kennefick M. Time Course of Corticospinal Excitability in Simple Reaction Time Tasks . [Thesis]. University of Ottawa; 2014. Available from: http://hdl.handle.net/10393/31504

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Tasmania

16. Clark, RM. Interneuron dysfunction in amyotrophic lateral sclerosis.

Degree: 2017, University of Tasmania

URL: https://eprints.utas.edu.au/23825/1/Clark_Rosemary_whole_thesis.pdf ; Clark, RM ORCID: 0000-0001-6156-6671 <https://orcid.org/0000-0001-6156-6671> 2017 , 'Interneuron dysfunction in amyotrophic lateral sclerosis', PhD thesis, University of Tasmania.

► Despite more than a century of research, there is still no cure for amyotrophic lateral sclerosis (ALS) and the only available therapeutic extends survival by… (more)

▼ Despite more than a century of research, there is still no cure for amyotrophic lateral sclerosis (ALS) and the only available therapeutic extends survival by mere months. The most common motor neuron (MN) disease, ALS is traditionally characterised by selective degeneration of MNs and the systematic destruction of the motor system. However, in the last decade the classification of ALS is evolving from a pure MN disease to be considered instead a multi-system, non-cell autonomous and complex neurodegenerative disease. With new insights into the pathological mechanisms underlying ALS there is increased interest in the regulatory mechanisms that may compromise MN function, in particular those that may contribute to an excitatory and inhibitory imbalance in the disease. Indeed, there is great interest in determining the biological basis for increased cortical hyperexcitability and impaired inhibition identified in the motor cortex of both familial and sporadic ALS patients. It is proposed that altered motor network excitability may be a central pathogenic mechanism in the disease, possibly initiating the final progressive decline of motor neuron function. While intrinsic regulation of the MN is likely implicated in this pathophysiology, loss of inhibitory network function is presumably mediated by intra-cortical inhibitory interneurons; however, the exact cell types responsible are yet to be identified. As such, the intent of this thesis was to examine the role of key inhibitory neuronal populations in the cortex, as they are crucial for normal brain functioning and the balance of excitatory neurotransmission. The current thesis is based upon the hypothesis that the “ALS pathogenesis involves cortical interneuron dysfunction”. The current thesis examined the role of cortical interneurons in disease by first establishing a timeline of cortical interneuron involvement in the motor circuitry of the `SOD1^(G93A)` mouse model of ALS. The intent of this initial study was to determine which interneurons are involved in disease, and the time frame of their alteration relative to symptom-onset and motor neuron deficits. Subsequently, the validity of interneuron pathology was established in post-mortem ALS cases. An additional aim of this secondary study was to determine the relationship between interneuron pathology, cortical pathology and clinical characteristics. The final study investigated the potential vulnerability of interneuron populations using an in vitro approach, with electrophysiological techniques designed to explore the innate susceptibility of interneurons in the presence of the `SOD1^(G93A)` mutation. This thesis determined that specific interneuron populations were altered within the motor cortex of the `SOD1^(G93A)` mouse model of ALS. Moreover, a novel timeline of interneuron involvement was identified that included dynamic changes in the density of NPY- and CR-expressing interneuron populations throughout the disease course. Changes originated in the upper cortical layers of the motor cortex from early…

Subjects/Keywords: Calretinin; neuropeptide Y; Interneuron; amyotrophic lateral sclerosis; motor cortex; excitability; SOD1; pathology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Clark, R. (2017). Interneuron dysfunction in amyotrophic lateral sclerosis. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/23825/1/Clark_Rosemary_whole_thesis.pdf ; Clark, RM ORCID: 0000-0001-6156-6671 <https://orcid.org/0000-0001-6156-6671> 2017 , 'Interneuron dysfunction in amyotrophic lateral sclerosis', PhD thesis, University of Tasmania.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Clark, RM. “Interneuron dysfunction in amyotrophic lateral sclerosis.” 2017. Thesis, University of Tasmania. Accessed March 05, 2021. https://eprints.utas.edu.au/23825/1/Clark_Rosemary_whole_thesis.pdf ; Clark, RM ORCID: 0000-0001-6156-6671 <https://orcid.org/0000-0001-6156-6671> 2017 , 'Interneuron dysfunction in amyotrophic lateral sclerosis', PhD thesis, University of Tasmania..

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Clark, RM. “Interneuron dysfunction in amyotrophic lateral sclerosis.” 2017. Web. 05 Mar 2021.

Vancouver:

Clark R. Interneuron dysfunction in amyotrophic lateral sclerosis. [Internet] [Thesis]. University of Tasmania; 2017. [cited 2021 Mar 05]. Available from: https://eprints.utas.edu.au/23825/1/Clark_Rosemary_whole_thesis.pdf ; Clark, RM ORCID: 0000-0001-6156-6671 <https://orcid.org/0000-0001-6156-6671> 2017 , 'Interneuron dysfunction in amyotrophic lateral sclerosis', PhD thesis, University of Tasmania..

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Clark R. Interneuron dysfunction in amyotrophic lateral sclerosis. [Thesis]. University of Tasmania; 2017. Available from: https://eprints.utas.edu.au/23825/1/Clark_Rosemary_whole_thesis.pdf ; Clark, RM ORCID: 0000-0001-6156-6671 <https://orcid.org/0000-0001-6156-6671> 2017 , 'Interneuron dysfunction in amyotrophic lateral sclerosis', PhD thesis, University of Tasmania.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

17. Cantone, Mariagiovanna. Vascular dementia: from clinical to biochemical and neurophysiological markers.

Degree: 2015, Università degli Studi di Catania

URL: http://hdl.handle.net/10761/3783

► BACKGROUND: Vascular Dementia can be considered the second most common cause of dementia after Alzheimer s disease. However, unlike the degenerative dementias, it s possible… (more)

Subjects/Keywords: Area 06 - Scienze mediche; Brain stimulation, Cognitive dysfunction, Cortical excitability, Motor impairment, Intracortical circuitry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cantone, M. (2015). Vascular dementia: from clinical to biochemical and neurophysiological markers. (Thesis). Università degli Studi di Catania. Retrieved from http://hdl.handle.net/10761/3783

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cantone, Mariagiovanna. “Vascular dementia: from clinical to biochemical and neurophysiological markers.” 2015. Thesis, Università degli Studi di Catania. Accessed March 05, 2021. http://hdl.handle.net/10761/3783.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cantone, Mariagiovanna. “Vascular dementia: from clinical to biochemical and neurophysiological markers.” 2015. Web. 05 Mar 2021.

Vancouver:

Cantone M. Vascular dementia: from clinical to biochemical and neurophysiological markers. [Internet] [Thesis]. Università degli Studi di Catania; 2015. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10761/3783.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cantone M. Vascular dementia: from clinical to biochemical and neurophysiological markers. [Thesis]. Università degli Studi di Catania; 2015. Available from: http://hdl.handle.net/10761/3783

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Vienna

18. Lechner, Stephan. Influence of mental preparation tasks on TMS-induced motor potentials.

Degree: 2018, University of Vienna

URL: http://othes.univie.ac.at/55538/

►

Diese Arbeit handelt von Motorkognition und untersucht den Effekt von Motorplänen auf die Bewegungsausführung. EMG-Aufnahmen wurden verwendet um festzustellen, ob die Versuchsteilnehmer eine durch TMS… (more)

▼

Diese Arbeit handelt von Motorkognition und untersucht den Effekt von Motorplänen auf die Bewegungsausführung. EMG-Aufnahmen wurden verwendet um festzustellen, ob die Versuchsteilnehmer eine durch TMS ausgelöste Bewegung des rechten Handgelenkes durch aktives Nachdenken vergrößern oder verkleinern können. Es wurden mehrere methodische Modifikationen zu einem bereits existierenden Versuchsaufbau von Bonnard et al. (2009) hinzugefügt, um die in früherer Forschung implizite Annahme, dass Teilnehmer die Fähigkeit haben die ausgelöste Bewegung zu verkleiner anstatt zu vergrößern, zu testen. Es wurde dargelegt, dass diese Annahme ohne beide Konditionen mit einer Baseline zu vergleichen, nicht haltbar ist. Auf der Basis von Forschungsergebnissen bezüglich der positiven Effekte von Vorstellen, Beobachten und Vorbereiten von Bewegungen auf neuronale Aktivität im motorischen Kortex wurde die Hypothese aufgestellt, dass es Versuchsteilnehmern ehermöglich sein sollte die ausgelöste Bewegung zu verstärken als sie zu verringern. Es wurde gezeigt, dass die Daten, die für den Zweck dieser Arbeit erhoben wurden, jene statistischen Tests, die in der vorherigen Studie von Bonnard et al. (2009) verwendet wurden, nicht zulassen. Die erhobenen Daten zeigten keine statistische Normalverteilung und drei verschiedene logarithmische sowie die Box-Cox Transformation konnten daran nichts ändern. Daher wurden andere statistische Tests verwendet, die allerdings die gefundenen Effekte von Bonnard et al. (2009) nicht replizieren konnten. Es wurde argumentiert, dass Variabilität zwischen sowie innerhalb der Subjekte der Grund dafür sein könnte.

This thesis deals with motor cognition by examining the effect of motor plans on movement execution. EMG recordings were used to determine whether participants are able to increase or decrease a TMS-induced motor twitch of the right wrist merely by actively thinking of influencing the movement. Several methodological modifications to an existing experimental paradigm by Bonnard et al. (2009) were made to test the implicit assumption that subjects can rather resist than assist. It was reasoned that without comparing both conditions to a baseline, it is not possible to draw this conclusion. Based on research examining the positive effect of imagination, observation and preparation of movement on neural activity in the motor cortex, it was hypothesized that subjects would rather be capable of assisting than resisting the induced movement, when measured against a baseline condition. It was found that the data recorded for the purpose of this thesis does not allow for the statistical tests that were used in the previous research by Bonnard et al. (2009). Data did not show a normal distribution, and three different logarithmic as well as the Box-Cox transformation could not remedy this fact. Different statistical tests were hence used that, however, could not replicate the effect found by Bonnard et al. (2009). It was argued that the cause for this might lie in inter-subject and within-subject variability…

Subjects/Keywords: 77.31 Kognition; Motorkognition / M1 Erregbarkeit / TMS / Kognitiv-motorische Schleife; motor cognition / M1 excitability / TMS / cognitive-motor loop

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lechner, S. (2018). Influence of mental preparation tasks on TMS-induced motor potentials. (Thesis). University of Vienna. Retrieved from http://othes.univie.ac.at/55538/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lechner, Stephan. “Influence of mental preparation tasks on TMS-induced motor potentials.” 2018. Thesis, University of Vienna. Accessed March 05, 2021. http://othes.univie.ac.at/55538/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lechner, Stephan. “Influence of mental preparation tasks on TMS-induced motor potentials.” 2018. Web. 05 Mar 2021.

Vancouver:

Lechner S. Influence of mental preparation tasks on TMS-induced motor potentials. [Internet] [Thesis]. University of Vienna; 2018. [cited 2021 Mar 05]. Available from: http://othes.univie.ac.at/55538/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lechner S. Influence of mental preparation tasks on TMS-induced motor potentials. [Thesis]. University of Vienna; 2018. Available from: http://othes.univie.ac.at/55538/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Wilfrid Laurier University

19. Cecire, Nathalie. Spinal Motor Neuron Excitability During Fatigue.

Degree: 2019, Wilfrid Laurier University

URL: https://scholars.wlu.ca/etd/2142

► Fatigue during sustained or repeated muscular contractions can be from contractile failure within the muscle or reduced excitability in the supraspinal and spinal motor neurons.… (more)

▼ Fatigue during sustained or repeated muscular contractions can be from contractile failure within the muscle or reduced excitability in the supraspinal and spinal motor neurons. However, spinal motor neurons can also compensate for fatigue. We speculate that one way the spinal motor neuron compensates for fatigue is through an increase in excitability via the activation of persistent inward currents (PIC). In other conditions where there is a reduction in descending drive, such as during spinal cord injury and aging, there are adaptions of the spinal motor neurons to have elevated PIC amplitudes or towards a greater prevalence of PIC, respectively. Although this increase may not necessarily be beneficial, it indicates that there is a compensatory increase in PIC during persistent reductions of descending drive. The purpose of this study was to explore how the motor neuron responds to fatigue by examining firing rates, PIC, and motor neuron pool excitability. Twelve participants attended two testing sessions. During one session the participants performed five three-minute sets of intermittent isometric plantarflexion contractions, during the other session the participants sat quietly. In both sessions participants performed maximal voluntary contractions and submaximal contractions for estimating PIC at the start, after each set, and again after fifteen minute of recovery. Using peripheral nerve stimulation, H-reflex and M-wave recruitment curves were elicited at the start, after the final set, and after fifteen minutes of recovery. Motor unit firing rates were assessed during the intermittent fatiguing contractions. Additional analyses were performed to assess whether the activation of the antagonist muscle group during fatigue influenced PIC, whether level of physical activity affected the initial PIC amplitude, and whether there were any sex-differences. There was no significant change in maximal voluntary force over the fatigue protocol, however there was a significant increase in muscle EMG during the fatiguing contractions. There were no significant changes in motor unit firing rates, spinal motor neuron pool excitability, or PIC. Although there was no change in PIC, a secondary analysis was performed to assess whether there was a sex-difference in PIC over the fatigue protocol. There was a significant interaction, indicating that females had a significant increase in PIC during the fatigue protocol, but males did not. There were no other interactions between session, time, and sex for the other measures of fatigue and motor neuron behaviour. Therefore, from these results we conclude that PIC is modulated during fatigue in women, but not men. This finding may contribute to our understanding of the mechanisms leading to greater fatigue-resistance in females. Further research should examine the stability of this relationship during more vigorous fatigue protocols.

Subjects/Keywords: neurophysiology; persistent inward current; spinal motor neuron excitability; H-reflex; motor unit firing rates; fatigue; Other Kinesiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cecire, N. (2019). Spinal Motor Neuron Excitability During Fatigue. (Thesis). Wilfrid Laurier University. Retrieved from https://scholars.wlu.ca/etd/2142

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cecire, Nathalie. “Spinal Motor Neuron Excitability During Fatigue.” 2019. Thesis, Wilfrid Laurier University. Accessed March 05, 2021. https://scholars.wlu.ca/etd/2142.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cecire, Nathalie. “Spinal Motor Neuron Excitability During Fatigue.” 2019. Web. 05 Mar 2021.

Vancouver:

Cecire N. Spinal Motor Neuron Excitability During Fatigue. [Internet] [Thesis]. Wilfrid Laurier University; 2019. [cited 2021 Mar 05]. Available from: https://scholars.wlu.ca/etd/2142.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cecire N. Spinal Motor Neuron Excitability During Fatigue. [Thesis]. Wilfrid Laurier University; 2019. Available from: https://scholars.wlu.ca/etd/2142

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

AUT University

20. Parker, Rosalind Sarah. Does chronic arthritic pain influence motor cortex excitability? .

Degree: AUT University

URL: http://hdl.handle.net/10292/8881

► Background: Painful hand arthritis is a major cause of disability worldwide including New Zealand, causing loss of function and reduced motor control. Arthritis is associated… (more)

▼ Background: Painful hand arthritis is a major cause of disability worldwide including New Zealand, causing loss of function and reduced motor control. Arthritis is associated with changes in central nociceptive processing and cortical reorganisation. Previous studies have shown an association between chronic pain and changes in corticomotor excitability. However, few studies have assessed corticomotor excitability in people with arthritis. Aims of the investigation: 1. To examine corticomotor and intracortical excitability in people with chronic hand pain due to arthritis. 2. To explore possible relationships between corticomotor excitability and pain variables. Methods: Transcranial magnetic stimulation (TMS) was used to measure the excitability of the corticomotor pathway to the first dorsal interosseus muscle in 23 people with chronic painful hand arthritis (median age 71; 17 female; median pain duration 9 years) and 20 pain-free control participants (median age 70.5; 14 female). Single-pulse TMS was used to establish the resting motor threshold (RTh), stimulus-response curves, and the cortical silent period duration (CSP). Paired-pulse TMS was used to examine short- and long-interval intracortical inhibition (SICI, LICI) and short-interval intracortical facilitation (SICF). SICI was assessed using conditioning stimulus intensities of 70% and 80% RTh (SICI70, SICI80) and an interstimulus interval (ISI) of 2 ms. The test stimulus was set to an intensity that elicited a motor evoked potential (MEP) of 1 mV (TS1mV). SICF was assessed using a conditioning stimulus of TS1mV, a test stimulus of 90% RTh, and ISIs of 1.4 and 2.8 ms (SICF1.4, SICF2.8). Outcome measures were compared between the two groups using Mann Whitney U tests due to several of the measures being non-normally distributed. Spearman’s rank correlations were used to explore the potential relationships between the corticomotor excitability measures and pain variables (pain duration, pain intensity and a measure of hand-related pain, stiffness and function). Results: The arthritis group demonstrated significantly enhanced SICF1.4 (p = 0.045) compared to the control group. RTh, stimulus-response curves, CSP duration, SICI70, SICI80, SICF2.8, and LICI were not significantly different between the two groups (all p>0.05). Moderate strength correlations were observed between the duration of hand pain and both measures of intracortical inhibition (SICI70 ρ = 0.38; SICI80 ρ = 0.434). There was a moderate strength correlation between the duration of hand pain and SICF1.4 (ρ = 0.346). Conclusions: This study provides evidence of enhanced facilitation in people with hand pain due to arthritis. No significant alterations in overall corticomotor excitability or inhibition were found. Relationships were observed between pain duration and intracortical excitability, with increased pain duration being associated with reduced inhibition and enhanced facilitation. This suggests that with increased hand pain duration, there is greater intracortical excitability.… Advisors/Committee Members: Lewis, Gwyn Nancy (advisor), McNair, Peter (advisor).

Subjects/Keywords: Motor cortex; TMS; Chronic pain; Arthritis; Intracortical; Corticomotor excitability

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APA (6^th Edition):

Parker, R. S. (n.d.). Does chronic arthritic pain influence motor cortex excitability? . (Thesis). AUT University. Retrieved from http://hdl.handle.net/10292/8881

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Parker, Rosalind Sarah. “Does chronic arthritic pain influence motor cortex excitability? .” Thesis, AUT University. Accessed March 05, 2021. http://hdl.handle.net/10292/8881.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Parker, Rosalind Sarah. “Does chronic arthritic pain influence motor cortex excitability? .” Web. 05 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Parker RS. Does chronic arthritic pain influence motor cortex excitability? . [Internet] [Thesis]. AUT University; [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10292/8881.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Parker RS. Does chronic arthritic pain influence motor cortex excitability? . [Thesis]. AUT University; Available from: http://hdl.handle.net/10292/8881

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

21. Moscoso, Ana Sofia Cueva. Elaboração de curva brasileira de normalidade de excitabilidade cortical.

Degree: PhD, Neurologia, 2013, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5138/tde-12032013-164222/ ;

► INTRODUÇÃO: A obtenção de medidas de excitabilidade cortical mediante a estimulação magnética transcraniana tem surgido nos últimos anos como método de avaliação da integridade funcional… (more)

▼ INTRODUÇÃO: A obtenção de medidas de excitabilidade cortical mediante a estimulação magnética transcraniana tem surgido nos últimos anos como método de avaliação da integridade funcional do trato cortico-spinal e rede interneuronal no córtex primário motor, abrindo perspectiva de utilizá-la na prática clínica. Alterações nos parâmetros de excitabilidade cortical tem sido relatados na síndrome fibromiálgica e outras síndromes dolorosas, se correlacionando com a gravidade de diferentes componentes dessas síndromes e mudando conforme o tratamento. Entretanto, apesar do seu potencial benefício, existe uma pequena quantidade de estudos disponíveis na literatura que tenham proposto a obtenção de dados de normalidade para esses parâmetros, com casuísticas pequenas, não pareadas por fatores que potencialmente alteraram seus valores. O presente estudo procurou montar uma curva de normalidade de parâmetros de excitabilidade cortical com cálculo de amostra, pareamento por idade e sexo, com estudo dos efeitos da lateralidade hemisférica e dominância, fase do ciclo menstrual e variabilidade inter e intraexaminador. MÉTODOS: Após cálculo amostral, foram convocados voluntários saudáveis do sexo masculino e feminino, pareados por idade. No total, 216 voluntários completaram o estudo. O potencial evocado motor, inibição intracortical e facilitação intracortical foram medidas no músculo primeiro interósseo dorsal após estímulo dos córtices motor primário bilateral. O grupo de 15 mulheres fez a primeira medição do uso de anticoncepcional oral e a segunda medição na fase de descanso do mesmo. A variabilidade interexaminador e intraexaminador foi aferida em 20 voluntários para cada uma das situações. RESULTADOS: A comparação entre os parâmetros de voluntários menores que 50 anos e maiores que 50 anos mostrou diferenças significativas. Foram obtidos os valores de normalidade para menores de 50 anos e maiores de 50 anos (média e desvio padrão): 1.Menores ou igual que 50 anos: LMR: 49 ± 9,39%; PEM 120%: 587,63±779,52 V; MEP 140%: 1413,08±1343,18 V; MEP 120/140%: 3,83±5,39 V; IIC 2ms: 0,40 ±0,44 V; IIC 4ms: 0,61± 0,84 V; IIC: 0,56± 0,63 V; FIC 10ms: 1,95 ±1,82 V; FIC 15ms: 1,80±1,73 V; FIC: 1,87±1,64 V. 2. Maiores de 50 anos: LMR: 49,1 ± 9.58%; PEM 120%:467,71±650,61 V; PEM 140%:1172,43±1158,47 V; PEM 120/140%: 4,04±4,27 V; IIC2ms: 0,73± 1,26 V; IIC 4ms: 1,04±1,67 V; IIC:0,81±1,03 V; FIC 10ms:2,46±3,85 V; FIC 15ms: 2,12±3,05 V; FIC: 2,28±3,32 V. Houve semelhança entre homens e mulheres( p>0,3). Os córtices motores direito e esquerdo apresentaram parâmetros semelhantes de excitabilidade cortical (p>0,25) para todas as análises. Assim, os valores para o hemisfério direito e esquerdo e os dados de homens e mulheres foram agrupados. Não houve diferença estatística significativa entre destros e sinistros (p>0,20). A variabilidade inter e intraexaminador é alta para a maior parte dos parâmetros, porém, com alta correlação para o limiar motor em repouso e potenciais evocados motores. A inibição e facilitação cortical tiveram baixa correlação, mas… Advisors/Committee Members: Andrade, Daniel Ciampi Araujo de.

Subjects/Keywords: Córtex motor; Cortical excitability; Estimulação magnética transcraniana; Evoked potentials; Excitabilidade cortical; Motor cortex; Potencial evocado; Reference values; Transcranial magnetic stimulation; Valores normais

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Moscoso, A. S. C. (2013). Elaboração de curva brasileira de normalidade de excitabilidade cortical. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5138/tde-12032013-164222/ ;

Chicago Manual of Style (16^th Edition):

Moscoso, Ana Sofia Cueva. “Elaboração de curva brasileira de normalidade de excitabilidade cortical.” 2013. Doctoral Dissertation, University of São Paulo. Accessed March 05, 2021. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-12032013-164222/ ;.

MLA Handbook (7^th Edition):

Moscoso, Ana Sofia Cueva. “Elaboração de curva brasileira de normalidade de excitabilidade cortical.” 2013. Web. 05 Mar 2021.

Vancouver:

Moscoso ASC. Elaboração de curva brasileira de normalidade de excitabilidade cortical. [Internet] [Doctoral dissertation]. University of São Paulo; 2013. [cited 2021 Mar 05]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5138/tde-12032013-164222/ ;.

Council of Science Editors:

Moscoso ASC. Elaboração de curva brasileira de normalidade de excitabilidade cortical. [Doctoral Dissertation]. University of São Paulo; 2013. Available from: http://www.teses.usp.br/teses/disponiveis/5/5138/tde-12032013-164222/ ;

University of Alberta

22. Lorenz, Chad D. Axon excitability testing shows increased IH activity in populations of slow versus fast motor axons of the rat.

Degree: MS, Physical Education and Recreation Centre for Neuroscience, 2013, University of Alberta

URL: https://era.library.ualberta.ca/files/70795812h

► Despite extensive knowledge of variations in motoneuron (MN) soma and muscle properties across different healthy muscles or motor units, there is comparatively little knowledge about… (more)

Subjects/Keywords: Axon; motor control; IH; axon plasticity; axon ion channels; ionic conductances; ALS; hyperpolarization-activated inwardly rectifying cation conductance; amyotrophic lateral sclerosis; Axon physiology; axon excitability testing; motor axons

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lorenz, C. D. (2013). Axon excitability testing shows increased IH activity in populations of slow versus fast motor axons of the rat. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/70795812h

Chicago Manual of Style (16^th Edition):

Lorenz, Chad D. “Axon excitability testing shows increased IH activity in populations of slow versus fast motor axons of the rat.” 2013. Masters Thesis, University of Alberta. Accessed March 05, 2021. https://era.library.ualberta.ca/files/70795812h.

MLA Handbook (7^th Edition):

Lorenz, Chad D. “Axon excitability testing shows increased IH activity in populations of slow versus fast motor axons of the rat.” 2013. Web. 05 Mar 2021.

Vancouver:

Lorenz CD. Axon excitability testing shows increased IH activity in populations of slow versus fast motor axons of the rat. [Internet] [Masters thesis]. University of Alberta; 2013. [cited 2021 Mar 05]. Available from: https://era.library.ualberta.ca/files/70795812h.

Council of Science Editors:

Lorenz CD. Axon excitability testing shows increased IH activity in populations of slow versus fast motor axons of the rat. [Masters Thesis]. University of Alberta; 2013. Available from: https://era.library.ualberta.ca/files/70795812h

23. Banzrai, Chimeglkham. Impaired Axonal Na+ Current by Hindlimb Unloading : Implication for Disuse Neuromuscular Atrophy : 尾懸垂による神経軸索Na+電流の障害 : 廃用性筋萎縮との関連の可能性.

Degree: 博士（医学）, 2016, Tokushima University / 徳島大学

URL: http://repo.lib.tokushima-u.ac.jp/109698

Subjects/Keywords: Disuse neuromuscular atrophy; hindlimb-unloading; motor axonal excitability; sodium current; neural plasticity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Banzrai, C. (2016). Impaired Axonal Na+ Current by Hindlimb Unloading : Implication for Disuse Neuromuscular Atrophy : 尾懸垂による神経軸索Na+電流の障害 : 廃用性筋萎縮との関連の可能性. (Thesis). Tokushima University / 徳島大学. Retrieved from http://repo.lib.tokushima-u.ac.jp/109698

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Banzrai, Chimeglkham. “Impaired Axonal Na+ Current by Hindlimb Unloading : Implication for Disuse Neuromuscular Atrophy : 尾懸垂による神経軸索Na+電流の障害 : 廃用性筋萎縮との関連の可能性.” 2016. Thesis, Tokushima University / 徳島大学. Accessed March 05, 2021. http://repo.lib.tokushima-u.ac.jp/109698.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Banzrai, Chimeglkham. “Impaired Axonal Na+ Current by Hindlimb Unloading : Implication for Disuse Neuromuscular Atrophy : 尾懸垂による神経軸索Na+電流の障害 : 廃用性筋萎縮との関連の可能性.” 2016. Web. 05 Mar 2021.

Vancouver:

Banzrai C. Impaired Axonal Na+ Current by Hindlimb Unloading : Implication for Disuse Neuromuscular Atrophy : 尾懸垂による神経軸索Na+電流の障害 : 廃用性筋萎縮との関連の可能性. [Internet] [Thesis]. Tokushima University / 徳島大学; 2016. [cited 2021 Mar 05]. Available from: http://repo.lib.tokushima-u.ac.jp/109698.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Banzrai C. Impaired Axonal Na+ Current by Hindlimb Unloading : Implication for Disuse Neuromuscular Atrophy : 尾懸垂による神経軸索Na+電流の障害 : 廃用性筋萎縮との関連の可能性. [Thesis]. Tokushima University / 徳島大学; 2016. Available from: http://repo.lib.tokushima-u.ac.jp/109698

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

24. Vila Villar, Aranza. Efectos de la estimulación con campos magnéticos estáticos transcraneales sobre la corteza prefrontal dorsolateral en la excitabilidad de la corteza motora .

Degree: 2019, Universidad da Coruña

URL: http://hdl.handle.net/2183/24489

► [Resumen]: Las técnicas de estimulación cerebral no invasiva (TECNI) comprenden varias modalidades diferentes que permiten modificar la excitabilidad cortical a través del cráneo; ello se… (more)

▼ [Resumen]: Las técnicas de estimulación cerebral no invasiva (TECNI) comprenden varias modalidades diferentes que permiten modificar la excitabilidad cortical a través del cráneo; ello se observa tanto en el área estimulada como en otras áreas funcionalmente conectadas con la misma. La estimulación con campos magnéticos estáticos (CME) es una de las TECNI de más reciente introducción, y ofrece la ventaja de su portabilidad, bajo coste y fácil administración. Se conoce su efecto sobre distintas áreas cerebrales, como la corteza motora, parietal o la occipital. Sin embargo, se desconoce si dicha técnica aplicada sobre la CPFDL es capaz de modificar la excitabilidad del área motora primaria (M1), algo que sí se ha mostrado con otras TECNI. Debido a esto, se plantea la hipótesis de que la aplicación de los CME sobre la corteza prefrontal dorsolateral (CPFDL) producirá cambios de la excitabilidad cortical a nivel de M1. Por tanto, el objetivo del presente trabajo es conocer los efectos de los CME en la excitabilidad de M1 izquierda tras su aplicación en la CPFDL ipsilateral. Para ello se seleccionaron 16 jóvenes diestros y sanos. Se realizaron diferentes mediciones en las cuales se incluyó la estimulación magnética transcraneal de par de pulsos en M1, para evaluar la excitabilidad intracortical (GABA-b dependiente) y la excitabilidad corticoespinal. La evaluación se realizó en dos sesiones distintas, una tras estimulación mediante CME reales y otra tras estimulación placebo, aleatorizadas en orden. En el presente experimento no se observaron cambios significativos en la excitabilidad de M1 tras la aplicación de los CME sobre la CPFDL. Dadas las características de simplicidad y portabilidad de la estimulación con CME, comprender si la misma permite modular la excitabilidad de redes funcionales es de gran relevancia, tanto desde una perspectiva fundamental como potencialmente clínica. Por lo que se puede concluir que son necesarias investigaciones futuras que apoyen o rebatan los presentes resultados. Advisors/Committee Members: Rivadulla, Casto (advisor), Arias, Pablo (advisor).

Subjects/Keywords: Estimulación magnética transcraneal; Campos magnéticos estáticos; Área Motora Primaria; Corteza Prefrontal Dorsolateral; Excitabilidad Cortical; Transcranial magnetic stimulation; Static magnetic fields; Primary Motor Area; Cortical excitability

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vila Villar, A. (2019). Efectos de la estimulación con campos magnéticos estáticos transcraneales sobre la corteza prefrontal dorsolateral en la excitabilidad de la corteza motora . (Masters Thesis). Universidad da Coruña. Retrieved from http://hdl.handle.net/2183/24489

Chicago Manual of Style (16^th Edition):

Vila Villar, Aranza. “Efectos de la estimulación con campos magnéticos estáticos transcraneales sobre la corteza prefrontal dorsolateral en la excitabilidad de la corteza motora .” 2019. Masters Thesis, Universidad da Coruña. Accessed March 05, 2021. http://hdl.handle.net/2183/24489.

MLA Handbook (7^th Edition):

Vila Villar, Aranza. “Efectos de la estimulación con campos magnéticos estáticos transcraneales sobre la corteza prefrontal dorsolateral en la excitabilidad de la corteza motora .” 2019. Web. 05 Mar 2021.

Vancouver:

Vila Villar A. Efectos de la estimulación con campos magnéticos estáticos transcraneales sobre la corteza prefrontal dorsolateral en la excitabilidad de la corteza motora . [Internet] [Masters thesis]. Universidad da Coruña; 2019. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/2183/24489.

Council of Science Editors:

Vila Villar A. Efectos de la estimulación con campos magnéticos estáticos transcraneales sobre la corteza prefrontal dorsolateral en la excitabilidad de la corteza motora . [Masters Thesis]. Universidad da Coruña; 2019. Available from: http://hdl.handle.net/2183/24489

Université de Sherbrooke

25. Martel, Marylie. Comprendre l’interaction entre la douleur et le système moteur : une étude novatrice combinant la stimulation magnétique transcrânienne et l’électroencéphalographie: Understanding the interaction between pain and motor system : an innovative study combining transcranial magnetic stimulation and electroencephalography.

Degree: 2016, Université de Sherbrooke

URL: http://hdl.handle.net/11143/9511

► Abstract : The interaction between pain and the motor system is well-known in clinic. For instance, it is well documented that pain significantly complicates the… (more)

Subjects/Keywords: Douleur; Système moteur; Excitabilité corticale; Connectivité fonctionnelle; Stimulation magnétique transcrânienne; Électroencéphalographie; Pain; Motor system; Cortical excitability; Functional connectivity; Transcranial magnetic stimulation; Electroencephalography

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Martel, M. (2016). Comprendre l’interaction entre la douleur et le système moteur : une étude novatrice combinant la stimulation magnétique transcrânienne et l’électroencéphalographie: Understanding the interaction between pain and motor system : an innovative study combining transcranial magnetic stimulation and electroencephalography. (Masters Thesis). Université de Sherbrooke. Retrieved from http://hdl.handle.net/11143/9511

Chicago Manual of Style (16^th Edition):

Martel, Marylie. “Comprendre l’interaction entre la douleur et le système moteur : une étude novatrice combinant la stimulation magnétique transcrânienne et l’électroencéphalographie: Understanding the interaction between pain and motor system : an innovative study combining transcranial magnetic stimulation and electroencephalography.” 2016. Masters Thesis, Université de Sherbrooke. Accessed March 05, 2021. http://hdl.handle.net/11143/9511.

MLA Handbook (7^th Edition):

Martel, Marylie. “Comprendre l’interaction entre la douleur et le système moteur : une étude novatrice combinant la stimulation magnétique transcrânienne et l’électroencéphalographie: Understanding the interaction between pain and motor system : an innovative study combining transcranial magnetic stimulation and electroencephalography.” 2016. Web. 05 Mar 2021.

Vancouver:

Martel M. Comprendre l’interaction entre la douleur et le système moteur : une étude novatrice combinant la stimulation magnétique transcrânienne et l’électroencéphalographie: Understanding the interaction between pain and motor system : an innovative study combining transcranial magnetic stimulation and electroencephalography. [Internet] [Masters thesis]. Université de Sherbrooke; 2016. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/11143/9511.

Council of Science Editors:

Martel M. Comprendre l’interaction entre la douleur et le système moteur : une étude novatrice combinant la stimulation magnétique transcrânienne et l’électroencéphalographie: Understanding the interaction between pain and motor system : an innovative study combining transcranial magnetic stimulation and electroencephalography. [Masters Thesis]. Université de Sherbrooke; 2016. Available from: http://hdl.handle.net/11143/9511

26. Kovalchuk, Maria. Measuring and modeling of axon membrane properties in motor neuron disorders and normal subjects.

Degree: 2019, University Utrecht

URL: https://dspace.library.uu.nl/handle/1874/388059 ; URN:NBN:NL:UI:10-1874-388059 ; urn:isbn:978-5-4465-2558-4 ; URN:NBN:NL:UI:10-1874-388059 ; https://dspace.library.uu.nl/handle/1874/388059

► In this thesis we present our research on two disorders of motor neurons: amyotrophic lateral sclerosis (ALS) and multifocal motor neuropathy (MMN). Amyotrophic lateral sclerosis… (more)

▼ In this thesis we present our research on two disorders of motor neurons: amyotrophic lateral sclerosis (ALS) and multifocal motor neuropathy (MMN). Amyotrophic lateral sclerosis (ALS) presents with muscle weakness, respiratory failure, and severe decrease of life expectancy. The symptoms develop due to upper and lower motor neuron loss of undefined reasons. No treatment, preventing austere invalidation in ALS, has been developed yet, but some novel therapies are currently approbated. Clinically ALS may overlap with MMN, a rare, chronic, immune-mediated neuropathy. MMN is a slowly progressive disease which does not affect patient longevity and is characterized by asymmetric weakness and atrophy of limb muscles. In MMN lower motor neurons in peripheral nerves are affected due to degeneration or multifocal loss of their myelin sheath. MMN is considered an immune-mediated neuropathy since in approximately half of the patients serum antibodies against ganglioside GM1 are found and administration of immunoglobulins induces improvement of muscle strength. The treatment effect is only temporary so that repeated administration is required. Despite treatment, muscle strength and loss of motor axons slowly progresses. Since functioning of the neuromuscular system depends on membrane properties of the axon, defined as nerve excitability and provided by ion channels and pumps, recording their activity would offer a unique chance to non-invasively evaluate the role of axonal membrane properties in specific clinical features of MMN and ALS and to assess the effect of medication on the axon in these disorders, where altered excitability was previously shown. Our study demonstrates the significance of implementing excitability testing both in scientific and clinical research of the motor neuron disorders, as it offers the possibility to assess the activity of axonal voltage-gated ion channels and sodium-potassium pump; to compare axon membrane properties in different types of axons; to explore nerve excitability in single motor units; to evaluate the disease progression where other techniques are not powerful enough; and to monitor the treatment effect. Advisors/Committee Members: van den Berg, Leonard, Franssen, Hessel, Sleutjes, Boudewijn.

Subjects/Keywords: motor neuron disorders; amyotrophic lateral sclerosis; multifocal motor neuropathy; excitability; axonal membrane properties; ion channels; mathematical modeling; sodium-potassium pump

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APA (6^th Edition):

Kovalchuk, M. (2019). Measuring and modeling of axon membrane properties in motor neuron disorders and normal subjects. (Doctoral Dissertation). University Utrecht. Retrieved from https://dspace.library.uu.nl/handle/1874/388059 ; URN:NBN:NL:UI:10-1874-388059 ; urn:isbn:978-5-4465-2558-4 ; URN:NBN:NL:UI:10-1874-388059 ; https://dspace.library.uu.nl/handle/1874/388059

Chicago Manual of Style (16^th Edition):

Kovalchuk, Maria. “Measuring and modeling of axon membrane properties in motor neuron disorders and normal subjects.” 2019. Doctoral Dissertation, University Utrecht. Accessed March 05, 2021. https://dspace.library.uu.nl/handle/1874/388059 ; URN:NBN:NL:UI:10-1874-388059 ; urn:isbn:978-5-4465-2558-4 ; URN:NBN:NL:UI:10-1874-388059 ; https://dspace.library.uu.nl/handle/1874/388059.

MLA Handbook (7^th Edition):

Kovalchuk, Maria. “Measuring and modeling of axon membrane properties in motor neuron disorders and normal subjects.” 2019. Web. 05 Mar 2021.

Vancouver:

Kovalchuk M. Measuring and modeling of axon membrane properties in motor neuron disorders and normal subjects. [Internet] [Doctoral dissertation]. University Utrecht; 2019. [cited 2021 Mar 05]. Available from: https://dspace.library.uu.nl/handle/1874/388059 ; URN:NBN:NL:UI:10-1874-388059 ; urn:isbn:978-5-4465-2558-4 ; URN:NBN:NL:UI:10-1874-388059 ; https://dspace.library.uu.nl/handle/1874/388059.

Council of Science Editors:

Kovalchuk M. Measuring and modeling of axon membrane properties in motor neuron disorders and normal subjects. [Doctoral Dissertation]. University Utrecht; 2019. Available from: https://dspace.library.uu.nl/handle/1874/388059 ; URN:NBN:NL:UI:10-1874-388059 ; urn:isbn:978-5-4465-2558-4 ; URN:NBN:NL:UI:10-1874-388059 ; https://dspace.library.uu.nl/handle/1874/388059

University of Otago

27. Sykes, Matthew John. The impact of high and low-intensity transcranial magnetic stimulation on measures of cortical excitability .

Degree: University of Otago

URL: http://hdl.handle.net/10523/7818

► In recent decades, transcranial magnetic stimulation (TMS) has emerged as one of the most promising techniques for clinical therapies. It has been proposed for use… (more)

▼ In recent decades, transcranial magnetic stimulation (TMS) has emerged as one of the most promising techniques for clinical therapies. It has been proposed for use in a wide number of neurophysiological disorders including Alzheimer’s, depression and stroke rehabilitation. The technique produces a heterogeneous magnetic field, which induces a suprathreshold electric field in a small focal zone of underlying cortical tissue, depolarising a population of neurons. When these pulses are applied in a repetitive fashion, known as repetitive TMS (rTMS), the excitability of the cortex can be altered. Outside of the small focal zone, broad areas of cortex are subject to much weaker induced current intensities, below the threshold for action potential generation, however, increasing evidence suggests they may have a measurable physiological impact. Despite great initial promise, clinical results for various rTMS treatment paradigms have been mixed, with response rates between and within patients showing high-variability. One potential source of this variability may be unintended effects of the low-intensity fields outside of the targeted population. The aim of the experiments in this thesis were to investigate the impact of rTMS at high- and low-intensities on measures of cortical excitability in the neocortex, using rodent models. The first study explored the effects of two separate anaesthetics on rTMS-induced changes in cortical excitability, using a high-intensity coil and measured using motor evoked potentials. Animals were anaesthetised with either a xylazine/zoletil combination or urethane. In contrast to previously reported success, high-intensity excitatory rTMS here was unable to increase MEP amplitudes, under either anaesthetic. The xylazine/zoletil combination however, was found to increase measures of excitability in the baseline recording, compared to animals anaesthetised with urethane. To investigate low-intensity rTMS, an 8-mm rodent specific coil was used for all subsequent experiments. This produced a magnetic field strength of 120 milliTesla, an order of magnitude below the 1-2 Tesla for human coils. Magnetic fields this powerful are comparable to those emitted by human coils outside of the focal zone. In the final two studies, the ability of low-intensity rTMS to depress or facilitate cortical excitability was measured directly using both local field potentials (LFPs) in vivo and calcium imaging of cortical neurons in vitro. Local field potentials were measured as contralaterally evoked waveforms in anaesthetised rats, recorded from layer V of the motor cortex. Brain slices of juvenile mice were prepared to measure the somatic levels of calcium in layer V neurons, as well as the amplitude of electrically evoked calcium transients. In both cases, rats or mouse brain slices were treated with low-intensity rTMS in the form of theta-burst stimulation or quadripulse stimulation. Overall, no significant effect of low-intensity rTMS was found in LFPs or somatic calcium levels. These data suggest that the effects… Advisors/Committee Members: Reynolds, John (advisor).

Subjects/Keywords: transcranial magnetic stimulation; cortical excitability; rTMS; local field potentials; motor evoked potentials; low intensity rTMS

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APA (6^th Edition):

Sykes, M. J. (n.d.). The impact of high and low-intensity transcranial magnetic stimulation on measures of cortical excitability . (Doctoral Dissertation). University of Otago. Retrieved from http://hdl.handle.net/10523/7818

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Chicago Manual of Style (16^th Edition):

Sykes, Matthew John. “The impact of high and low-intensity transcranial magnetic stimulation on measures of cortical excitability .” Doctoral Dissertation, University of Otago. Accessed March 05, 2021. http://hdl.handle.net/10523/7818.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

MLA Handbook (7^th Edition):

Sykes, Matthew John. “The impact of high and low-intensity transcranial magnetic stimulation on measures of cortical excitability .” Web. 05 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Sykes MJ. The impact of high and low-intensity transcranial magnetic stimulation on measures of cortical excitability . [Internet] [Doctoral dissertation]. University of Otago; [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10523/7818.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Council of Science Editors:

Sykes MJ. The impact of high and low-intensity transcranial magnetic stimulation on measures of cortical excitability . [Doctoral Dissertation]. University of Otago; Available from: http://hdl.handle.net/10523/7818

Note: this citation may be lacking information needed for this citation format:
No year of publication.

28. Littmann, Andrew Edwards. Use-dependent plasticity of the human central nervous system: the influence of motor learning and whole body heat stress.

Degree: PhD, Physical Rehabilitation Science, 2012, University of Iowa

URL: https://ir.uiowa.edu/etd/2931

► The human central nervous system (CNS) is capable of significant architectural and physiological reorganization in response to environmental stimuli. Novel sensorimotor experiences stimulate neuronal… (more)

▼ The human central nervous system (CNS) is capable of significant architectural and physiological reorganization in response to environmental stimuli. Novel sensorimotor experiences stimulate neuronal networks to modify their intrinsic excitability and spatial connectivity within and between CNS structures. Early learning-induced adaptations in the primary motor cortex are thought to serve as a priming stimulus for long term CNS reorganization underlying long-lasting changes in motor skill. Recent animal and human studies suggest that whole body exercise and core temperature elevation as systemic stressors also recruit activity-dependent processes that prime the motor cortex, cerebellum, and hippocampus to process sensorimotor stimuli from the environment, enhancing overall CNS learning and performance. A primary goal of rehabilitation specialists is to evaluate and design activity-based intervention strategies that induce or enhance beneficial neuroplastic processes across the lifespan. As such, an investgation of the influence of physical, non-pharmacological interventions on cortical excitability, motor learning, and cognitive function provide the central theme of this dissertation. The first study investigated the effects of a visually-guided motor learning task on motor cortex excitability at rest and during voluntary activation measured via transcranical magnetic stimulation (TMS). Motor learning significantly increased resting cortical excitability that was not accompanied by changes in excitability as a function of voluntary muscle activation. The cortical silent period, a measure of inhibition, increased after learning and was associated with the magnitude of learning at low activation. These findings suggest that separate excitatory and inhibitory mechanisms may influence motor output as a function of learning success. The following studies investigated the influence of systemic whole-body thermal stress on motor cortex excitability, motor learning and cognitive performance. We established the reliability of a novel TMS cortical mapping procedure to study neurophysiological responses after whole-body heat stress. Heat stress significantly potentiated motor cortex excitability, though acute motor learning and cognitive test performance did not differ between subjects receiving heat stress and control subjects. Future research is needed to delineate the potential of whole body heat stress as a therapeutic modality to influence central nervous system plasticity and performance. Advisors/Committee Members: Shields, Richard K. (supervisor).

Subjects/Keywords: Cortical Excitability; Heat Stress; Motor Learning; Plasticity; Transcranial Magnetic Stimulation; Rehabilitation and Therapy

…27 CHAPTER III VARIABILITY OF MOTOR CORTICAL EXCITABILITY USING A NEWLY DEVELOPED MAPPING… …47 CHAPTER IV THE INFLUENCE OF WHOLE BODY HEAT STRESS ON MOTOR CORTICAL EXCITABILITY, MOTOR… …pharmacological interventions on plasticity of cortical excitability, motor learning, and cognitive… …excitability and density of motor neurons at the focal point of the electrical field and the… …motor cortex excitability and functional connections with surrounding cortical cells (25…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Littmann, A. E. (2012). Use-dependent plasticity of the human central nervous system: the influence of motor learning and whole body heat stress. (Doctoral Dissertation). University of Iowa. Retrieved from https://ir.uiowa.edu/etd/2931

Chicago Manual of Style (16^th Edition):

Littmann, Andrew Edwards. “Use-dependent plasticity of the human central nervous system: the influence of motor learning and whole body heat stress.” 2012. Doctoral Dissertation, University of Iowa. Accessed March 05, 2021. https://ir.uiowa.edu/etd/2931.

MLA Handbook (7^th Edition):

Littmann, Andrew Edwards. “Use-dependent plasticity of the human central nervous system: the influence of motor learning and whole body heat stress.” 2012. Web. 05 Mar 2021.

Vancouver:

Littmann AE. Use-dependent plasticity of the human central nervous system: the influence of motor learning and whole body heat stress. [Internet] [Doctoral dissertation]. University of Iowa; 2012. [cited 2021 Mar 05]. Available from: https://ir.uiowa.edu/etd/2931.

Council of Science Editors:

Littmann AE. Use-dependent plasticity of the human central nervous system: the influence of motor learning and whole body heat stress. [Doctoral Dissertation]. University of Iowa; 2012. Available from: https://ir.uiowa.edu/etd/2931

University of Florida

29. Chhabra, Anuja. Impact of Expiratory Muscle Strength Training on Cortical Excitability of the Lateral Abdominal Musculature.

Degree: PhD, Communication Sciences and Disorders, 2008, University of Florida

URL: https://ufdc.ufl.edu/UFE0022018

► Strength gains in skeletal muscles typically occur within the first few weeks of exposure to an overload stimulus and have been associated with changes within… (more)

Subjects/Keywords: Abdomen; Abdominal muscles; Cough; Diaphragm; Magnetism; Motor cortex; Neurons; Physiology; Strength training; Vertices; abdominal, cortical, emst, excitability, muscles, neuroplasticity, tms

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chhabra, A. (2008). Impact of Expiratory Muscle Strength Training on Cortical Excitability of the Lateral Abdominal Musculature. (Doctoral Dissertation). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0022018

Chicago Manual of Style (16^th Edition):

Chhabra, Anuja. “Impact of Expiratory Muscle Strength Training on Cortical Excitability of the Lateral Abdominal Musculature.” 2008. Doctoral Dissertation, University of Florida. Accessed March 05, 2021. https://ufdc.ufl.edu/UFE0022018.

MLA Handbook (7^th Edition):

Chhabra, Anuja. “Impact of Expiratory Muscle Strength Training on Cortical Excitability of the Lateral Abdominal Musculature.” 2008. Web. 05 Mar 2021.

Vancouver:

Chhabra A. Impact of Expiratory Muscle Strength Training on Cortical Excitability of the Lateral Abdominal Musculature. [Internet] [Doctoral dissertation]. University of Florida; 2008. [cited 2021 Mar 05]. Available from: https://ufdc.ufl.edu/UFE0022018.

Council of Science Editors:

Chhabra A. Impact of Expiratory Muscle Strength Training on Cortical Excitability of the Lateral Abdominal Musculature. [Doctoral Dissertation]. University of Florida; 2008. Available from: https://ufdc.ufl.edu/UFE0022018

30. Lefebvre Omar, Cynthia. Défauts intrinsèques de motoneurones spinaux dérivés de cellules souches pluripotentes induites issues d’individus atteints de différentes formes de Sclérose Latérale Amyotrophique : Comparison of motor neuron intrinsic defects in patients with various forms of Amyotrophic Lateral Sclerosis.

Degree: Docteur es, Neurosciences, 2018, Sorbonne université

URL: http://www.theses.fr/2018SORUS507

►

La Sclérose Latérale Amyotrophique (SLA) est une maladie neurodégénérative caractérisée par la mort des motoneurones (MNs). Malgré plusieurs hypothèses pouvant expliquer les mécanismes à l’origine… (more)

▼

La Sclérose Latérale Amyotrophique (SLA) est une maladie neurodégénérative caractérisée par la mort des motoneurones (MNs). Malgré plusieurs hypothèses pouvant expliquer les mécanismes à l’origine de leur mort sélective, l’hétérogénéité de la SLA rend difficile la compréhension des causes exactes de la dégénérescence. Dans ce contexte, les cellules souches pluripotentes induites humaines (iPSC) permettent l’étude des formes familiales de la maladie comme des formes sporadiques. Contrairement à la majorité des travaux publiés à ce jour qui étudient des iPSC de patients porteurs de mutation dans un seul gène de SLA, mon projet a eu pour objectif de comparer plusieurs formes de SLA dans un même contexte expérimental. A partir d’iPSC de patients présentant différentes formes génétiques de SLA (C9ORF72, SOD1, TARDBP), nous avons obtenu des cultures pures de MNs humains. Alors que nous n’avons pas observé de mort des MNs mutants après plusieurs semaines, des études fonctionnelles d’électrophysiologie ont montré une altération tardive de l’excitabilité des MNs en fonction des patients. De façon plus précoce, nous avons observé la présence d’agrégats protéiques communs ou spécifiques aux différentes formes de SLA, avec certaines accumulations localisées au niveau du segment proximal de l’axone, une région importante pour la maintenance de l’identité axonale et le déclenchement des potentiels d’action. Des altérations physiques ou moléculaires ont été mises en évidence au niveau de ce segment dans les MNs mutants, suggérant qu’une perturbation du segment proximal de l’axone pourrait être un évènement très précoce altérant ainsi l’intégrité et la fonctionnalité des MNs de patients.

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized by motor neurons death (MNs). Despite several hypothesis trying to explain this selective loss, the exact reasons of MNs degeneration remain unidentified mainly due to the disease heterogeneity. In this respect, the use of human induced pluripotent stem cells (iPSC) are opening up opportunities to model not only familial but also sporadic forms of ALS. In comparison to previously published studies, which focus only on one type of ALS mutation, my thesis had the objective to compare in a same experimental context multiple forms of ALS in order to distinguish similarities and discrepancies inherited by the mutation. Using iPSC obtained from genetic forms of ALS patients (C9ORF72, SOD1, TARDBP) as well as control subjects, we generated pure cultures of human MNs. While ALS MNs were not sensitive to death after few weeks of culture, electrophysiological functional studies revealed a patient-dependent late alteration in MNs excitability. Early defects were also reported, with observations of generic and mutation-specific protein aggregates. Interestingly, some accumulations were localized at the axonal initial segment (AIS) region, which is important for maintaining axonal identity and crucial for action potentials’ initiation. Physical and/or molecular alterations were…

Advisors/Committee Members: Bohl, Delphine (thesis director).

Subjects/Keywords: Sclérose latérale amyotrophique; Motoneurones; Cellules souches pluripotentes induites; Segment initial de l'axone; Agrégats; Excitabilité; Amyotrophic Lateral Sclerosis; Motor neurons; Human induced pluripotent stem cells; Axonal initial segment; Aggregates; Excitability; 616.839; 616.02774

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lefebvre Omar, C. (2018). Défauts intrinsèques de motoneurones spinaux dérivés de cellules souches pluripotentes induites issues d’individus atteints de différentes formes de Sclérose Latérale Amyotrophique : Comparison of motor neuron intrinsic defects in patients with various forms of Amyotrophic Lateral Sclerosis. (Doctoral Dissertation). Sorbonne université. Retrieved from http://www.theses.fr/2018SORUS507

Chicago Manual of Style (16^th Edition):

Lefebvre Omar, Cynthia. “Défauts intrinsèques de motoneurones spinaux dérivés de cellules souches pluripotentes induites issues d’individus atteints de différentes formes de Sclérose Latérale Amyotrophique : Comparison of motor neuron intrinsic defects in patients with various forms of Amyotrophic Lateral Sclerosis.” 2018. Doctoral Dissertation, Sorbonne université. Accessed March 05, 2021. http://www.theses.fr/2018SORUS507.

MLA Handbook (7^th Edition):

Lefebvre Omar, Cynthia. “Défauts intrinsèques de motoneurones spinaux dérivés de cellules souches pluripotentes induites issues d’individus atteints de différentes formes de Sclérose Latérale Amyotrophique : Comparison of motor neuron intrinsic defects in patients with various forms of Amyotrophic Lateral Sclerosis.” 2018. Web. 05 Mar 2021.

Vancouver:

Lefebvre Omar C. Défauts intrinsèques de motoneurones spinaux dérivés de cellules souches pluripotentes induites issues d’individus atteints de différentes formes de Sclérose Latérale Amyotrophique : Comparison of motor neuron intrinsic defects in patients with various forms of Amyotrophic Lateral Sclerosis. [Internet] [Doctoral dissertation]. Sorbonne université; 2018. [cited 2021 Mar 05]. Available from: http://www.theses.fr/2018SORUS507.

Council of Science Editors:

Lefebvre Omar C. Défauts intrinsèques de motoneurones spinaux dérivés de cellules souches pluripotentes induites issues d’individus atteints de différentes formes de Sclérose Latérale Amyotrophique : Comparison of motor neuron intrinsic defects in patients with various forms of Amyotrophic Lateral Sclerosis. [Doctoral Dissertation]. Sorbonne université; 2018. Available from: http://www.theses.fr/2018SORUS507

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Open Access Theses and Dissertations