subject:(Model animal)

Wake Forest University

1. Marquez-Lara, Alejandro J. INFLAMMATION AND FRACTURE HEALING: A NEW PARADIGM.

Degree: 2019, Wake Forest University

► Inflammation plays a fundamental role in bone healing. This complex process is regulated by a myriad of cells and inflammatory mediators that create an adequate… (more)

Subjects/Keywords: Animal model

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APA (6^th Edition):

Marquez-Lara, A. J. (2019). INFLAMMATION AND FRACTURE HEALING: A NEW PARADIGM. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/94326

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Marquez-Lara, Alejandro J. “INFLAMMATION AND FRACTURE HEALING: A NEW PARADIGM.” 2019. Thesis, Wake Forest University. Accessed February 28, 2021. http://hdl.handle.net/10339/94326.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Marquez-Lara, Alejandro J. “INFLAMMATION AND FRACTURE HEALING: A NEW PARADIGM.” 2019. Web. 28 Feb 2021.

Vancouver:

Marquez-Lara AJ. INFLAMMATION AND FRACTURE HEALING: A NEW PARADIGM. [Internet] [Thesis]. Wake Forest University; 2019. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10339/94326.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Marquez-Lara AJ. INFLAMMATION AND FRACTURE HEALING: A NEW PARADIGM. [Thesis]. Wake Forest University; 2019. Available from: http://hdl.handle.net/10339/94326

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

2. Alrobaiea, Saad Mohammad. A Novel Nude Mouse Model of Hypertrophic Scarring Using Scratched Full-Thickness Human Skin Grafts.

Degree: MS, Department of Surgery, 2015, University of Alberta

URL: https://era.library.ualberta.ca/files/c4q77fr539

► Hypertrophic scar (HTS) is a dermal form of fibroproliferative disorder that develops following deep skin injury. This dermal fibrosis can cause deformities, functional disabilities, and… (more)

▼ Hypertrophic scar (HTS) is a dermal form of fibroproliferative disorder that develops following deep skin injury. This dermal fibrosis can cause deformities, functional disabilities, and aesthetic disfigurements. The pathophysiology of HTS is not understood due in part, to the lack of an ideal animal model. We hypothesize that human skin with dermal wounds of a depth known to reproducibly cause HTS once grafted onto athymic nude mice will develop a raised elevated scar similar to HTS seen in humans. Our aim is to develop a representative animal model of human HTS and to explore the cellular origin of the fibrosis either locally derived from the deep dermal human fibroblasts or from the bone marrow derived monocytes of the mouse. Thirty-six nude mice were grafted with full thickness human skin with deep dermal scratch wound before or 2 weeks after grafting. The scratch on the human skin grafts was made using a specially designed jig creates a wound > 0.6 mm in depth which has been demonstrated to be the depth of injury in human skin volunteers beyond which HTS consistently develops. Deep dermal wounds in the human skin grafts transplanted on to the dorsal surface of athymic mice were morphologically analyzed by digital photography. Mice were euthanized at one, two, and three months postoperatively before histological analysis of scar thickness, collagen synthesis and fiber orientation, mast cells, macrophages, human leukocyte antigen-ABC, and myofibroblasts was performed. Morphologic persistence of human fibroblasts in the raised elevated scar was documented up to one-year post engraftment using human anti-ABC antibodies. The mice developed red, raised, and firm scars in the scratched xenografts with more contraction, increased recruitment of macrophages and myofibroblasts as compared to the xenografts without deep dermal scratch wound. Scar thickness and collagen bundle orientation and morphology were resembled that seen in human HTS in the deep dermal wounds within the engrafted human skin on the dorsum of the mice. The fibrotic scars in the wounded human skin were morphologically and histologically similar to human HTS and human skin epithelial cells and fibroblasts persisted in the remodelling tissues for at least one year post-engraftment. Thus, deep dermal injury in human skin retains its profibrotic nature after transplantation, affording a novel model for the assessment of therapies for the treatment of human fibroproliferative disorders of the skin.

Subjects/Keywords: Hypertrophic Scars; Animal model; Scars

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APA (6^th Edition):

Alrobaiea, S. M. (2015). A Novel Nude Mouse Model of Hypertrophic Scarring Using Scratched Full-Thickness Human Skin Grafts. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/c4q77fr539

Chicago Manual of Style (16^th Edition):

Alrobaiea, Saad Mohammad. “A Novel Nude Mouse Model of Hypertrophic Scarring Using Scratched Full-Thickness Human Skin Grafts.” 2015. Masters Thesis, University of Alberta. Accessed February 28, 2021. https://era.library.ualberta.ca/files/c4q77fr539.

MLA Handbook (7^th Edition):

Alrobaiea, Saad Mohammad. “A Novel Nude Mouse Model of Hypertrophic Scarring Using Scratched Full-Thickness Human Skin Grafts.” 2015. Web. 28 Feb 2021.

Vancouver:

Alrobaiea SM. A Novel Nude Mouse Model of Hypertrophic Scarring Using Scratched Full-Thickness Human Skin Grafts. [Internet] [Masters thesis]. University of Alberta; 2015. [cited 2021 Feb 28]. Available from: https://era.library.ualberta.ca/files/c4q77fr539.

Council of Science Editors:

Alrobaiea SM. A Novel Nude Mouse Model of Hypertrophic Scarring Using Scratched Full-Thickness Human Skin Grafts. [Masters Thesis]. University of Alberta; 2015. Available from: https://era.library.ualberta.ca/files/c4q77fr539

3. Monga, Jitender. Antiproliferative and chemopreventive potential of acacia catechu willd against multiorgan carcinoma.

Degree: Pharmaceutical Sciences, 2013, Jaypee University of Information Technology, Solan

URL: http://shodhganga.inflibnet.ac.in/handle/10603/14082

►

Cancer or the malignancies of the cells has been considered as one of the most dreadly disease. Tissue invasiveness and metastatic spread of cancer cells… (more)

Subjects/Keywords: Acacia Catechu; Animal Model; Carcinoma

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APA (6^th Edition):

Monga, J. (2013). Antiproliferative and chemopreventive potential of acacia catechu willd against multiorgan carcinoma. (Thesis). Jaypee University of Information Technology, Solan. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/14082

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Monga, Jitender. “Antiproliferative and chemopreventive potential of acacia catechu willd against multiorgan carcinoma.” 2013. Thesis, Jaypee University of Information Technology, Solan. Accessed February 28, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/14082.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Monga, Jitender. “Antiproliferative and chemopreventive potential of acacia catechu willd against multiorgan carcinoma.” 2013. Web. 28 Feb 2021.

Vancouver:

Monga J. Antiproliferative and chemopreventive potential of acacia catechu willd against multiorgan carcinoma. [Internet] [Thesis]. Jaypee University of Information Technology, Solan; 2013. [cited 2021 Feb 28]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/14082.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Monga J. Antiproliferative and chemopreventive potential of acacia catechu willd against multiorgan carcinoma. [Thesis]. Jaypee University of Information Technology, Solan; 2013. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/14082

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Otago

4. Grant, Mark Wayne. Anatomical and physiological characterization of a novel porcine model for varicose veins .

Degree: 2012, University of Otago

URL: http://hdl.handle.net/10523/2235

► Varicose veins constitute a significant financial and social burden. Despite being well documented since Hippocrates, there is still a lack of understanding concerning both the… (more)

▼ Varicose veins constitute a significant financial and social burden. Despite being well documented since Hippocrates, there is still a lack of understanding concerning both the underlying pathogenesis and the rationale of treatments of varicose veins. The management of varicose veins is marked by confusion and debate, which could benefit from well-designed experiments in a suitable animal model. Especially as the current available therapies for the treatment of varicose veins is limited by their high recurrence rates. While studying neointimal hyperplasia in arterial ends of common femoral AVF created in pig models we, at the Department of Surgery in Dunedin Hospital, observed that the pigs also developed progressive enlargement and tortuosity of the superficial veins over the medial aspect the thigh and groin. These changes in superficial veins developed into what appeared to be an extensive network of varicose veins. This novel finding has not been described to the same extent in other animal models of venous disease. Consequently, the aim of this thesis is to further characterize a porcine model of varicose veins. Eleven female domesticated large white Duroc cross pigs, aged 13-14 weeks and weights 25.1- 35 kg, were used in this research project (control pigs [n=2], surgery animals [n=9]). The first animal was used to assist in the characterisation the normal anatomy of pigs’ hind limb, the nominal saphenous vein and its relations and the sapheno- femoral junction. Each of the remaining animals had a right common femoral side to side arteriovenous fistula (AVF) fashioned by a vascular surgeon. Post-operatively the animals were assessed to document of macroscopic changes of venous vasculature, characterise the physiological changes that occur within the superficial venous system and to document any histological changes in the vessel wall. Venous hypertension was demonstrated within the superficial varicosities, 23±11.4 mmHg at the mid point of the study, and 20±8.3 mmHg at termination, while in the control it was 4.5± 3.5 mmHg. In all but one pig with an AVF there was variation in pressure, associated with the cardiac cycle. The flow velocities also demonstrated a degree of pulsatility. Overall there was both an intra-vessel and inter-animal heterogeneity to the vessel walls changes seen in the veins sampled. Finding which were consistently seen included: variable neointimal formation, medial hypertrophy, fragmentation of the medial and adventitial elastic tissue, and medial and mural atrophy. Areas of greatest intimal thickness were associated with disruption of the internal elastic lamina. A variety of valvular defects were also observed with the specimens including bilateral and unilateral elongation of cusps, and valve cusp tearing. In conclusion we describe a stable and chronic porcine AVF model of venous insufficiency, which is simple to create and closely replicates the human condition of venous insufficiency and superficial varicose veins. The formation of an AVF between the femoral vessels… Advisors/Committee Members: Jones, Gregory (advisor).

Subjects/Keywords: varicose; animal; veins; model

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APA (6^th Edition):

Grant, M. W. (2012). Anatomical and physiological characterization of a novel porcine model for varicose veins . (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/2235

Chicago Manual of Style (16^th Edition):

Grant, Mark Wayne. “Anatomical and physiological characterization of a novel porcine model for varicose veins .” 2012. Masters Thesis, University of Otago. Accessed February 28, 2021. http://hdl.handle.net/10523/2235.

MLA Handbook (7^th Edition):

Grant, Mark Wayne. “Anatomical and physiological characterization of a novel porcine model for varicose veins .” 2012. Web. 28 Feb 2021.

Vancouver:

Grant MW. Anatomical and physiological characterization of a novel porcine model for varicose veins . [Internet] [Masters thesis]. University of Otago; 2012. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10523/2235.

Council of Science Editors:

Grant MW. Anatomical and physiological characterization of a novel porcine model for varicose veins . [Masters Thesis]. University of Otago; 2012. Available from: http://hdl.handle.net/10523/2235

University of Melbourne

5. LIU, HSIN-HUA. A novel rat model of ocular hypertension induced by a circumlimbal suture.

Degree: 2014, University of Melbourne

URL: http://hdl.handle.net/11343/51340

► The aim of the thesis is to develop a rat model of non-inflammatory, chronic ocular hypertension that produces glaucomatous optic neuropathy. Oculo-pression with circumlimbal suture… (more)

Subjects/Keywords: animal model of glaucoma

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APA (6^th Edition):

LIU, H. (2014). A novel rat model of ocular hypertension induced by a circumlimbal suture. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/51340

Chicago Manual of Style (16^th Edition):

LIU, HSIN-HUA. “A novel rat model of ocular hypertension induced by a circumlimbal suture.” 2014. Doctoral Dissertation, University of Melbourne. Accessed February 28, 2021. http://hdl.handle.net/11343/51340.

MLA Handbook (7^th Edition):

LIU, HSIN-HUA. “A novel rat model of ocular hypertension induced by a circumlimbal suture.” 2014. Web. 28 Feb 2021.

Vancouver:

LIU H. A novel rat model of ocular hypertension induced by a circumlimbal suture. [Internet] [Doctoral dissertation]. University of Melbourne; 2014. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/11343/51340.

Council of Science Editors:

LIU H. A novel rat model of ocular hypertension induced by a circumlimbal suture. [Doctoral Dissertation]. University of Melbourne; 2014. Available from: http://hdl.handle.net/11343/51340

University of Southern California

6. Liu, Ying. Insights from mouse models on the origin of ovarian cancer and its predisposing mechanisms.

Degree: PhD, Pathobiology, 2014, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/247625/rec/3514

► Ovarian cancers are the leading cause of death from gynecological cancer in the U.S. and more than 70% of the patients are diagnosed with disseminated… (more)

▼ Ovarian cancers are the leading cause of death from gynecological cancer in the U.S. and more than 70% of the patients are diagnosed with disseminated disease. Thus, the ability to detect ovarian cancer precursor lesions before they develop into fully mature cancers would have a profound impact on the morbidity and mortality of the disease. However, the exact site of origin of ovarian cancer is not fully understood. The purpose of my thesis is to develop heritable mouse models for epithelial ovarian tumors to answer key questions regarding ovarian cancer origin and address the underlying predisposing mechanisms. ❧ Dr. Dubeau has argued for many years, that the currently favoured hypothesis that tumors lesions that are currently classified ovarian epithelial tumors do not arise from the coelomic epithelium that covers the ovary, but from derivatives of the müllerian ducts. In order to test our hypothesis, we generated transgenic constructs where the Müllerian inhibiting substance type 2 receptor (Mis2r) promoter drives expression of either β-galactosidase (Mis2r-β–Gal) or Cre recombinase (Mis2r-Cre), we found no evidence of an embryological link between the müllerian ducts and coelomic epithelium, however, a segment of the renal tubules specific for the female gender might suggest an embryological link between the müllerian ducts and renal development. This is important not only to a development point of view, but also helped us understand histogenesis of clear cell ovarian carcinomas. ❧ We also created a mouse model by superimposing p53 knockout targeted specifically to müllerian tract on the Brca1 mutation already present in Fshr-Cre; Brca1 flox/flox mice. Tumors possibly from mammary glands were observed in 60% of mice with double knockout, and they were epithelial in nature. This model would be a useful tool to study the role of loss of function of p53 and Brca1 in cancers relevant to ovary and mammary glands in origin, which will further augment our understanding on human BRCA1-mutated related cancer. ❧ The gene profiling changes between wide type and mutant mice with Brca1 inactivation in ovarian granulosa cells showed the gene family that was most frequently influenced was that of olfactory receptor. We validated the presence of olfactory receptors in mouse and human granulosa cells and further hypothesized those olfactory receptors may play a role in signal transduction in granulosa cells and contribute to ovarian tumor predisposition by regulating mice estrous cycle. ❧ Our previous work has been using homozygous Brca1 mutation in ovarian granulosa cells to maximize the effects of Brca1 inactivation, we also want to test our hypothesis that the effects of a heterozygous mutation is similar due to the gene dosage effect, such as present in human BRCA1 mutation carriers. Advisors/Committee Members: Dubeau, Louis (Committee Chair), Taylor, Clive R. (Committee Member), Chuong, Cheng-Ming (Committee Member), Maxson, Robert E., Jr. (Committee Member).

Subjects/Keywords: ovarian cancer; animal model

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APA (6^th Edition):

Liu, Y. (2014). Insights from mouse models on the origin of ovarian cancer and its predisposing mechanisms. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/247625/rec/3514

Chicago Manual of Style (16^th Edition):

Liu, Ying. “Insights from mouse models on the origin of ovarian cancer and its predisposing mechanisms.” 2014. Doctoral Dissertation, University of Southern California. Accessed February 28, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/247625/rec/3514.

MLA Handbook (7^th Edition):

Liu, Ying. “Insights from mouse models on the origin of ovarian cancer and its predisposing mechanisms.” 2014. Web. 28 Feb 2021.

Vancouver:

Liu Y. Insights from mouse models on the origin of ovarian cancer and its predisposing mechanisms. [Internet] [Doctoral dissertation]. University of Southern California; 2014. [cited 2021 Feb 28]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/247625/rec/3514.

Council of Science Editors:

Liu Y. Insights from mouse models on the origin of ovarian cancer and its predisposing mechanisms. [Doctoral Dissertation]. University of Southern California; 2014. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/247625/rec/3514

University of New South Wales

7. Rodriguez Paris, Valentina. Impact of hyperandrogenism and diet on the development of polycystic ovary syndrome.

Degree: Women's & Children's Health, 2020, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/69717 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:71270/SOURCE02?view=true

► Polycystic ovary syndrome (PCOS) is a heterogeneous disorder featuring reproductive, endocrine and metabolic abnormalities. Hyperandrogenism is a defining characteristic of PCOS and evidence supports a… (more)

▼ Polycystic ovary syndrome (PCOS) is a heterogeneous disorder featuring reproductive, endocrine and metabolic abnormalities. Hyperandrogenism is a defining characteristic of PCOS and evidence supports a role for androgen driven actions in the development of PCOS. The aetiology of PCOS is poorly understood and current management is symptom based. Therefore, defining the ontogeny of PCOS traits and the factors impacting their development, is important for developing early PCOS detection markers and new treatment strategies. The aims of this research were to determine the temporal pattern of development of PCOS features in a hyperandrogenic environment, define the impact of dietary macronutrient balance on hyperandrogenic PCOS traits and evaluate the impact of diet and a hyperandrogenic PCOS pathology on the gut microbiome using a mouse model. The first study characterised the temporal pattern of development of PCOS features after excess androgen exposure. Findings identified that acyclicity, anovulation and increased body weight are early predictors of developing PCOS. The second study utilized the geometric framework for nutrition and reports the first systematic analysis of dietary protein, carbohydrate and fat on the evolution of reproductive and metabolic PCOS traits in a PCOS mouse model. Results revealed that reproductive PCOS features of acyclicity and anovulation were ameliorated on low protein, medium carbohydrate and fat consumption. In contrast, diet had minimal effect on PCOS metabolic features. Specifically, PCOS mice were significantly heavier compared to controls due to an increased sensitivity to caloric intake, implying differences in post-ingestive responses to diet. Therefore, the third study investigated the interplay between diet and PCOS pathology on gut microbiota and revealed that diet exerted a stronger influence over gut microbial composition than PCOS. However, a PCOS environment did decrease levels of an obesity associated Bacteroides species. Overall, findings provide insights into the sequence of PCOS trait development, the impact of diet on PCOS features, and the interplay between diet and PCOS pathology on the gut microbiome, and support the addition of body weight criteria to the early diagnosis of PCOS and future research into the development of evidence-based nutritional and microbiome-mediated strategies for the treatment of PCOS. Advisors/Committee Members: Walters, Kirsty, Women's & Children's Health, Faculty of Medicine, UNSW, Gilchrist, Robert, Women's & Children's Health, Faculty of Medicine, UNSW, Bertoldo, Michael, Women's & Children's Health, Faculty of Medicine, UNSW.

Subjects/Keywords: Diet; PCOS; Hyperandrogenism; Animal model

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APA (6^th Edition):

Rodriguez Paris, V. (2020). Impact of hyperandrogenism and diet on the development of polycystic ovary syndrome. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/69717 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:71270/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Rodriguez Paris, Valentina. “Impact of hyperandrogenism and diet on the development of polycystic ovary syndrome.” 2020. Doctoral Dissertation, University of New South Wales. Accessed February 28, 2021. http://handle.unsw.edu.au/1959.4/69717 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:71270/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Rodriguez Paris, Valentina. “Impact of hyperandrogenism and diet on the development of polycystic ovary syndrome.” 2020. Web. 28 Feb 2021.

Vancouver:

Rodriguez Paris V. Impact of hyperandrogenism and diet on the development of polycystic ovary syndrome. [Internet] [Doctoral dissertation]. University of New South Wales; 2020. [cited 2021 Feb 28]. Available from: http://handle.unsw.edu.au/1959.4/69717 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:71270/SOURCE02?view=true.

Council of Science Editors:

Rodriguez Paris V. Impact of hyperandrogenism and diet on the development of polycystic ovary syndrome. [Doctoral Dissertation]. University of New South Wales; 2020. Available from: http://handle.unsw.edu.au/1959.4/69717 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:71270/SOURCE02?view=true

8. 鮫島, 直樹. The values of wall shear stress, turbulence kinetic energy and blood pressure gradient are associated with atherosclerotic plaque erosion in rabbits : 動脈硬化巣におけるびらん性傷害に関与する血行力学的因子の検討 : 家兎動脈硬化モデルでのコンピューターシュミレーション解析.

Degree: 博士(医学), 2014, University of Miyazaki / 宮崎大学

URL: http://hdl.handle.net/10458/4966

►

以下に掲載:Journal of Atherosclerosis and Thrombosis. 2014, 21, 8, p.831-838, doi: 10.5551/jat.23093.

Aim: To clarify the contribution of hemodynamic factors to the onset of plaque erosion… (more)

Subjects/Keywords: Plaque erosion; Animal model; Computational fluid dynamics

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APA (6^th Edition):

鮫島, �. (2014). The values of wall shear stress, turbulence kinetic energy and blood pressure gradient are associated with atherosclerotic plaque erosion in rabbits : 動脈硬化巣におけるびらん性傷害に関与する血行力学的因子の検討 : 家兎動脈硬化モデルでのコンピューターシュミレーション解析. (Thesis). University of Miyazaki / 宮崎大学. Retrieved from http://hdl.handle.net/10458/4966

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

鮫島, 直樹. “The values of wall shear stress, turbulence kinetic energy and blood pressure gradient are associated with atherosclerotic plaque erosion in rabbits : 動脈硬化巣におけるびらん性傷害に関与する血行力学的因子の検討 : 家兎動脈硬化モデルでのコンピューターシュミレーション解析.” 2014. Thesis, University of Miyazaki / 宮崎大学. Accessed February 28, 2021. http://hdl.handle.net/10458/4966.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

鮫島, 直樹. “The values of wall shear stress, turbulence kinetic energy and blood pressure gradient are associated with atherosclerotic plaque erosion in rabbits : 動脈硬化巣におけるびらん性傷害に関与する血行力学的因子の検討 : 家兎動脈硬化モデルでのコンピューターシュミレーション解析.” 2014. Web. 28 Feb 2021.

Vancouver:

鮫島 �. The values of wall shear stress, turbulence kinetic energy and blood pressure gradient are associated with atherosclerotic plaque erosion in rabbits : 動脈硬化巣におけるびらん性傷害に関与する血行力学的因子の検討 : 家兎動脈硬化モデルでのコンピューターシュミレーション解析. [Internet] [Thesis]. University of Miyazaki / 宮崎大学; 2014. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10458/4966.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

鮫島 �. The values of wall shear stress, turbulence kinetic energy and blood pressure gradient are associated with atherosclerotic plaque erosion in rabbits : 動脈硬化巣におけるびらん性傷害に関与する血行力学的因子の検討 : 家兎動脈硬化モデルでのコンピューターシュミレーション解析. [Thesis]. University of Miyazaki / 宮崎大学; 2014. Available from: http://hdl.handle.net/10458/4966

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

9. Hong, Mandy. The Effects of Docosahexaenoic Acid (DHA) Dietary Supplementation in a Mouse Model of Stargardt-like Macular Dystrophy (STGD3).

Degree: MS, Centre for Neuroscience, 2013, University of Alberta

URL: https://era.library.ualberta.ca/files/h702q689j

► Underlying mechanisms of how docosahexaenoic acid (DHA) might impact the progression of macular degeneration are unknown. We relied on the ELOVL4 mouse model of juvenile… (more)

Subjects/Keywords: Docasahexaenoic Acid (DHA); Animal Model; Retinal Degeneration

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APA (6^th Edition):

Hong, M. (2013). The Effects of Docosahexaenoic Acid (DHA) Dietary Supplementation in a Mouse Model of Stargardt-like Macular Dystrophy (STGD3). (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/h702q689j

Chicago Manual of Style (16^th Edition):

Hong, Mandy. “The Effects of Docosahexaenoic Acid (DHA) Dietary Supplementation in a Mouse Model of Stargardt-like Macular Dystrophy (STGD3).” 2013. Masters Thesis, University of Alberta. Accessed February 28, 2021. https://era.library.ualberta.ca/files/h702q689j.

MLA Handbook (7^th Edition):

Hong, Mandy. “The Effects of Docosahexaenoic Acid (DHA) Dietary Supplementation in a Mouse Model of Stargardt-like Macular Dystrophy (STGD3).” 2013. Web. 28 Feb 2021.

Vancouver:

Hong M. The Effects of Docosahexaenoic Acid (DHA) Dietary Supplementation in a Mouse Model of Stargardt-like Macular Dystrophy (STGD3). [Internet] [Masters thesis]. University of Alberta; 2013. [cited 2021 Feb 28]. Available from: https://era.library.ualberta.ca/files/h702q689j.

Council of Science Editors:

Hong M. The Effects of Docosahexaenoic Acid (DHA) Dietary Supplementation in a Mouse Model of Stargardt-like Macular Dystrophy (STGD3). [Masters Thesis]. University of Alberta; 2013. Available from: https://era.library.ualberta.ca/files/h702q689j

Vanderbilt University

10. Mergy, Marc Andrew. Generation and Characterization of the First Construct-Valid Model of ADHD, the DAT Val559 Knock-In Mouse.

Degree: PhD, Neuroscience, 2013, Vanderbilt University

URL: http://hdl.handle.net/1803/14625

► Attention-deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed childhood neuropsychiatric disorder. More than twenty years of genetic, behavioral, and pharmacological research support the hypothesis that… (more)

Subjects/Keywords: transporter; dopamine; ADHD; transgenic; mouse; animal model

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APA (6^th Edition):

Mergy, M. A. (2013). Generation and Characterization of the First Construct-Valid Model of ADHD, the DAT Val559 Knock-In Mouse. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/14625

Chicago Manual of Style (16^th Edition):

Mergy, Marc Andrew. “Generation and Characterization of the First Construct-Valid Model of ADHD, the DAT Val559 Knock-In Mouse.” 2013. Doctoral Dissertation, Vanderbilt University. Accessed February 28, 2021. http://hdl.handle.net/1803/14625.

MLA Handbook (7^th Edition):

Mergy, Marc Andrew. “Generation and Characterization of the First Construct-Valid Model of ADHD, the DAT Val559 Knock-In Mouse.” 2013. Web. 28 Feb 2021.

Vancouver:

Mergy MA. Generation and Characterization of the First Construct-Valid Model of ADHD, the DAT Val559 Knock-In Mouse. [Internet] [Doctoral dissertation]. Vanderbilt University; 2013. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1803/14625.

Council of Science Editors:

Mergy MA. Generation and Characterization of the First Construct-Valid Model of ADHD, the DAT Val559 Knock-In Mouse. [Doctoral Dissertation]. Vanderbilt University; 2013. Available from: http://hdl.handle.net/1803/14625

McMaster University

11. Nicolini, Chiara. DEFECTIVE TrkB SIGNALING PATHWAYS IN IDIOPATHIC AUTISM.

Degree: PhD, 2016, McMaster University

URL: http://hdl.handle.net/11375/20034

►

Autism is a neurodevelopmental disorder characterized by impairments in social communication and interaction and by repetitive patterns of behaviour, interests and activities. It is perhaps… (more)

▼

Autism is a neurodevelopmental disorder characterized by impairments in social communication and interaction and by repetitive patterns of behaviour, interests and activities. It is perhaps the most common and handicapping neurological disorder of childhood and as such represents a significant public health problem and a huge burden for education and social service systems. Currently there is no diagnostic test or cure available for autism and the molecular mechanisms underlying autistic behaviour remain to be elucidated. Mutations in genes linked to autism adversely affect molecules involved in synapse development and plasticity including brain-derived neurotrophic factor receptor (TrkB) and its downstream effector mammalian target of rapamycin (mTOR), which is increased in several forms of syndromic autism. Here, we investigated whether TrkB, mTOR and their signaling pathways are disrupted in postmortem brain tissue from subjects with idiopathic autism, that is, cases of autism without a known genetic cause and thought to be of environmental/epigenetic origin. We next further examined the contribution of defective TrkB signaling to autistic behaviour in mice exposed to the histone deacetylase inhibitor valproic acid (VPA), a well-established model of environmental/epigenetic origin of autism. We found that TrkB signaling pathways were reduced in idiopathic autism and that these disruptions were associated with decreased excitatory postsynaptic marker PSD-95, suggesting fewer excitatory synapses. Moreover, we showed that similar molecular deficits were present in VPA-exposed mice that lacked sociability and displayed increased repetitive, stereotyped behaviour. We also determined that behavioural deficits in these mice were rescued by administration of the partial TrkB agonist LM22A-4 but not by treatment with the active tripeptide fragment of the insulin-like growth factor-1, (1-3)IGF-1. Lastly, reduced TrkB signaling in VPA-exposed mice was normalized by LM22A-4 administration combined with behavioural enrichment. The present work provides a better understanding of the molecular mechanisms that contribute to autistic behaviour and implicates TrkB signaling in autism pathogenesis. Furthermore, these data demonstrate that molecular changes observed in brains of patients with idiopathic autism differ from syndromic forms and highlight that both too much and too little signaling can be equally disruptive. The present work also shows that maternal challenge with VPA resulted in social deficits, increased repetitive, restrictive behaviour and reduced TrkB signaling in mice, pointing to epigenetic modifications as a potential underlying mechanism of molecular and behavioural disruptions in autism. Lastly, these findings suggest that pharmacological activation of TrkB using compounds such as the partial TrkB agonist LM22A-4 might play a role in treating sociability and repetitive, perseverative behaviour in autism.

Thesis

Doctor of Philosophy (PhD)

Advisors/Committee Members: Fahnestock, Margaret, Medical Sciences (Division of Physiology/Pharmacology).

Subjects/Keywords: Autism; LM22A-4; TrkB; VPA; Animal Model

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APA (6^th Edition):

Nicolini, C. (2016). DEFECTIVE TrkB SIGNALING PATHWAYS IN IDIOPATHIC AUTISM. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/20034

Chicago Manual of Style (16^th Edition):

Nicolini, Chiara. “DEFECTIVE TrkB SIGNALING PATHWAYS IN IDIOPATHIC AUTISM.” 2016. Doctoral Dissertation, McMaster University. Accessed February 28, 2021. http://hdl.handle.net/11375/20034.

MLA Handbook (7^th Edition):

Nicolini, Chiara. “DEFECTIVE TrkB SIGNALING PATHWAYS IN IDIOPATHIC AUTISM.” 2016. Web. 28 Feb 2021.

Vancouver:

Nicolini C. DEFECTIVE TrkB SIGNALING PATHWAYS IN IDIOPATHIC AUTISM. [Internet] [Doctoral dissertation]. McMaster University; 2016. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/11375/20034.

Council of Science Editors:

Nicolini C. DEFECTIVE TrkB SIGNALING PATHWAYS IN IDIOPATHIC AUTISM. [Doctoral Dissertation]. McMaster University; 2016. Available from: http://hdl.handle.net/11375/20034

North Carolina State University

12. Liu, Zifei. Measurement and Modeling Ammonia Emissions from Broiler Litter.

Degree: PhD, Biological and Agricultural Engineering, 2009, North Carolina State University

URL: http://www.lib.ncsu.edu/resolver/1840.16/5458

► Ammonia is a very important atmospheric pollutant. Agricultural activities, livestock production in particular, have been reported to be the largest contributor of ammonia emissions into… (more)

▼ Ammonia is a very important atmospheric pollutant. Agricultural activities, livestock production in particular, have been reported to be the largest contributor of ammonia emissions into the atmosphere. Accurate estimation of ammonia emission rate from individual operations or sources is important and yet a challenging task for both regulatory agencies and animal producers. The overall research objective of this study was to develop an emission model which can be used to estimate ammonia emission from broiler litter. In the reported model, the ammonia flux is essentially a function of the litter's total ammoniacal nitrogen (TAN) content, moisture content, pH, and temperature, as well as the Freundlich partition coefficient (Kf), mass transfer coefficient (KG), ventilation rate (Q), and emission surface area (A). A dynamic flow-through chamber system and a wind tunnel were designed to measure ammonia fluxes from broiler litter. The dynamic flow-through chamber experiments evaluated the reported model with various litter samples under a constant temperature and wind profile. The wind tunnel experiments evaluated the reported model under various temperatures and wind profiles. Model parameters such as Kf and KG were estimated. The results from the two experiments were consistent with each other. The estimated KG ranged from 1.11 to 27.64 m h-1, and the estimated Kf ranged from 0.56 to 4.48 L kg-1. Regression sub-models were developed to estimate Kf as a function of litter pH and temperature and to estimate KG as a function of air velocity and temperature. Sensitivity analysis of the model showed that ammonia flux is very sensitive to litter pH and to a lesser extent temperature. A validation metric based on the mean and covariance in the measurement and in the model parameters were used to validate the ammonia emission model in the presence of measurement and model parameter uncertainties. Advisors/Committee Members: Peter Bloomfield, Committee Member (advisor), Sanjay Shah, Committee Member (advisor), David Beasley , Committee Co-Chair (advisor), Lingjuan Wang, Committee Chair (advisor).

Subjects/Keywords: emission; model; ammonia; animal feeding operation

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APA (6^th Edition):

Liu, Z. (2009). Measurement and Modeling Ammonia Emissions from Broiler Litter. (Doctoral Dissertation). North Carolina State University. Retrieved from http://www.lib.ncsu.edu/resolver/1840.16/5458

Chicago Manual of Style (16^th Edition):

Liu, Zifei. “Measurement and Modeling Ammonia Emissions from Broiler Litter.” 2009. Doctoral Dissertation, North Carolina State University. Accessed February 28, 2021. http://www.lib.ncsu.edu/resolver/1840.16/5458.

MLA Handbook (7^th Edition):

Liu, Zifei. “Measurement and Modeling Ammonia Emissions from Broiler Litter.” 2009. Web. 28 Feb 2021.

Vancouver:

Liu Z. Measurement and Modeling Ammonia Emissions from Broiler Litter. [Internet] [Doctoral dissertation]. North Carolina State University; 2009. [cited 2021 Feb 28]. Available from: http://www.lib.ncsu.edu/resolver/1840.16/5458.

Council of Science Editors:

Liu Z. Measurement and Modeling Ammonia Emissions from Broiler Litter. [Doctoral Dissertation]. North Carolina State University; 2009. Available from: http://www.lib.ncsu.edu/resolver/1840.16/5458

University of Toronto

13. Zdravic, Darko. Investigation of the Pathophysiological Mechanisms of Intracranial Hemorrhage and Miscarriage in alphaIIb Integrin Mediated Fetal and Neonatal Alloimmune Thrombocytopenia.

Degree: 2017, University of Toronto

URL: http://hdl.handle.net/1807/76676

►

Investigation of the Pathophysiological Mechanisms of Intracranial Hemorrhage and Miscarriage in anti-alphaIIb Integrin Mediated Fetal and Neonatal Alloimmune Thrombocytopenia Darko Zdravic Master of Science Department… (more)

Subjects/Keywords: animal model; antibody; placenta; platelets; thrombocytopenia;

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APA (6^th Edition):

Zdravic, D. (2017). Investigation of the Pathophysiological Mechanisms of Intracranial Hemorrhage and Miscarriage in alphaIIb Integrin Mediated Fetal and Neonatal Alloimmune Thrombocytopenia. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/76676

Chicago Manual of Style (16^th Edition):

Zdravic, Darko. “Investigation of the Pathophysiological Mechanisms of Intracranial Hemorrhage and Miscarriage in alphaIIb Integrin Mediated Fetal and Neonatal Alloimmune Thrombocytopenia.” 2017. Masters Thesis, University of Toronto. Accessed February 28, 2021. http://hdl.handle.net/1807/76676.

MLA Handbook (7^th Edition):

Zdravic, Darko. “Investigation of the Pathophysiological Mechanisms of Intracranial Hemorrhage and Miscarriage in alphaIIb Integrin Mediated Fetal and Neonatal Alloimmune Thrombocytopenia.” 2017. Web. 28 Feb 2021.

Vancouver:

Zdravic D. Investigation of the Pathophysiological Mechanisms of Intracranial Hemorrhage and Miscarriage in alphaIIb Integrin Mediated Fetal and Neonatal Alloimmune Thrombocytopenia. [Internet] [Masters thesis]. University of Toronto; 2017. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1807/76676.

Council of Science Editors:

Zdravic D. Investigation of the Pathophysiological Mechanisms of Intracranial Hemorrhage and Miscarriage in alphaIIb Integrin Mediated Fetal and Neonatal Alloimmune Thrombocytopenia. [Masters Thesis]. University of Toronto; 2017. Available from: http://hdl.handle.net/1807/76676

14. Caulder, Erin. Metabotropic glutamate receptors as targets for antiepileptic drug therapy: a behavioral and electroencephalographic analysis.

Degree: 2013, Wake Forest University

URL: http://hdl.handle.net/10339/38534

► Epilepsy is a relatively common neurological disorder that involves recurrent seizures thought to be caused by an imbalance in the excitatory and inhibitory systems in… (more)

▼ Epilepsy is a relatively common neurological disorder that involves recurrent seizures thought to be caused by an imbalance in the excitatory and inhibitory systems in the brain, in favor of excitation. Unfortunately, some types of epilepsy have drug resistance rates of up to 40%. Classically, targets for antiepileptic drugs have included glutamatergic ion channels. However, interfering with excitatory signalling at these channels can alter normal neural communication and can have negative side effects, including cognitive dysfunction and fatigue, which are among the most common complaints from patients. Given the high rate of drug-resistant patients, and the high rate of deleterious side effects, there is an obvious need to develop novel drugs with novel targets and mechanisms of action. Compounds targeting metabotropic glutamate receptors (mGluRs; specifically mGlur2 and 3) have shown promise in other hyperexcitatory neural disorders, and some have shown efficacy in models of epilepsy as well. The goal of these studies was to demonstrate a conclusive behavioral effect of particular mGluR active compounds in reducing the severity of seizures associated with two models of epilepsy. Both models that were used are models of generalized seizure, although one is characterized by convulsive seizures (pilocarpine model) and the other is characterized by the lack of convulsive seizure, or an "absence" seizure (GBL model). Mice were given mGluR2/3 active drugs either before or after seizure onset and behavioral observations relating to seizure were measured. In some cases, the mice had been implanted with tethered EEG devices to record neural activity that coincided with behavioral observations and measures. It was demonstrated that in generalized models of seizure, mGluR2/3 active agonists had some efficacy at reducing seizure severity. The effect of modulators at mGluR2 was also investigated. One in particular, CBiPES had a modest but significant effect in reducing the behavioral severity of pilocarpine induced seizures, but not of GBL induced seizures. In conclusion, mGluR2/3 remains a valid target for antiepileptic drug development. The ideal compound would yield higher response rates for patients while boasting a minimal negative side effect profile.

Subjects/Keywords: animal model

…considered a valid model of absense: the behavior of the epileptic animal is similar to epileptic… …seizure) has been used in animals as a model of epilepsy for decades (Racine, 1978… …involved in epileptogenesis and in seizures are relatively well known and understood. Animal… …rodent model systems offers many theories. Epileptic seizures can result in the excitotoxic… …support the epileptogenic process in the human and experimental animal brain. 2. Channelopathies…

10 more images…

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APA (6^th Edition):

Caulder, E. (2013). Metabotropic glutamate receptors as targets for antiepileptic drug therapy: a behavioral and electroencephalographic analysis. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/38534

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Caulder, Erin. “Metabotropic glutamate receptors as targets for antiepileptic drug therapy: a behavioral and electroencephalographic analysis.” 2013. Thesis, Wake Forest University. Accessed February 28, 2021. http://hdl.handle.net/10339/38534.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Caulder, Erin. “Metabotropic glutamate receptors as targets for antiepileptic drug therapy: a behavioral and electroencephalographic analysis.” 2013. Web. 28 Feb 2021.

Vancouver:

Caulder E. Metabotropic glutamate receptors as targets for antiepileptic drug therapy: a behavioral and electroencephalographic analysis. [Internet] [Thesis]. Wake Forest University; 2013. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10339/38534.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Caulder E. Metabotropic glutamate receptors as targets for antiepileptic drug therapy: a behavioral and electroencephalographic analysis. [Thesis]. Wake Forest University; 2013. Available from: http://hdl.handle.net/10339/38534

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Otago

15. Hegan, William Matthew. Gambling Behaviour in Pigeons: Toward an Animal Model of Gambling .

Degree: 2011, University of Otago

URL: http://hdl.handle.net/10523/1646

► The gambling addiction is a destructive impulse control disorder that leaves families destitute and lives in ruins. The treatment and pathology of gambling has become… (more)

▼ The gambling addiction is a destructive impulse control disorder that leaves families destitute and lives in ruins. The treatment and pathology of gambling has become a popular area of research, reflected in national media campaigns here in New Zealand. Studies suggest that there are prefrontal activation differences in problem gamblers compared to healthy volunteers, areas involved with decision making and reward. Animal research has begun to investigate an animal model of gambling, with some studies showing behavioural similarities between animals and humans when playing gambling tasks. The current thesis sought to further investigate an animal model of gambling, performing two experiments using a slot machine task. Experiment 1 was an investigation into the neural basis of gambling, examining the behaviour of single neurons in the avian NCL, an equivalent to the mammalian prefrontal cortex. Four pigeons (Columba livia) served as subjects and played a touch screen slot machine task, similar to a slot machine found in any casino. Pigeons were required to peck an upright arm to initiate each trial, and then peck four rolling tumblers in succession from left to right. If four identical stimuli appeared, then a wheat reward was won. During the task, activity from single NCL neurons was recorded. Four neuronal types were found to correlate with gambling related behaviour: Reward Proximity neurons, I-Won neurons, I-Lost neurons and Near Win neurons. In addition pigeons were split into two groups with one group trained for a short (one month) and long (four month) period, in an attempt to mimic naive and problem gamblers. It was hypothesised that due to prolonged training the two groups would differ in the amount and magnitude of firing of these neurons. Results showed no statistical difference between groups in either amount of gambling neurons or magnitude of firing. Behavioural data were also collected and it was hypothesised that all birds would show evidence of a post reinforcement pause, something our results confirmed. Experiment 2 investigated whether pigeons, similar to humans, show a preference to play slot machines with higher near win ratios. Four pigeons were again tested on a touch screen slot machine task, required to play on two different ‘machines’ differentiated by different coloured backgrounds. It was hypothesised that when pigeons were given a choice, they would choose the machine that had the higher percentage of near win trials. Our results did not show evidence of any preference, and it was concluded that the near win effect may not be replicable in animals. In conclusion, the current thesis demonstrates that neurons in the avian NCL code for gambling behaviours while pigeons play a slot machine task. Although an analogue of slot machine gambling may be found in animals, our findings suggest gambling characteristics such as the near win effect may not be replicable. The current findings provide a base for further research to investigate an animal model of gambling. Advisors/Committee Members: Colombo, Michael (advisor).

Subjects/Keywords: Gambling Research; Gambling; Avian; Pigeon; Animal Model

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APA (6^th Edition):

Hegan, W. M. (2011). Gambling Behaviour in Pigeons: Toward an Animal Model of Gambling . (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/1646

Chicago Manual of Style (16^th Edition):

Hegan, William Matthew. “Gambling Behaviour in Pigeons: Toward an Animal Model of Gambling .” 2011. Masters Thesis, University of Otago. Accessed February 28, 2021. http://hdl.handle.net/10523/1646.

MLA Handbook (7^th Edition):

Hegan, William Matthew. “Gambling Behaviour in Pigeons: Toward an Animal Model of Gambling .” 2011. Web. 28 Feb 2021.

Vancouver:

Hegan WM. Gambling Behaviour in Pigeons: Toward an Animal Model of Gambling . [Internet] [Masters thesis]. University of Otago; 2011. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10523/1646.

Council of Science Editors:

Hegan WM. Gambling Behaviour in Pigeons: Toward an Animal Model of Gambling . [Masters Thesis]. University of Otago; 2011. Available from: http://hdl.handle.net/10523/1646

Colorado State University

16. Soffler, Carl. Development and characterization of caprine infection models of melioidosis, The.

Degree: PhD, Microbiology, Immunology, and Pathology, 2012, Colorado State University

URL: http://hdl.handle.net/10217/71589

► Melioidosis, the disease resulting from infection with Burkholderia pseudomallei, is a serious emerging infectious disease endemic to Southeast Asia and Northern Australasia and a leading… (more)

▼ Melioidosis, the disease resulting from infection with Burkholderia pseudomallei, is a serious emerging infectious disease endemic to Southeast Asia and Northern Australasia and a leading infectious cause of death in the former. Additionally, B. pseudomallei has been designated a Category B Select Agent by the United States Centers for Disease Control and Prevention because of its potential use in bioterrorism, which has led to intensive research on inhalational models of murine melioidosis. Natural infection is believed to occur predominantly through percutaneous inoculation or inhalation in the rainy season in endemic areas, with infection following oral exposure occurring to a lesser extent. However, the actual importance of each route of infection in natural disease is unknown. Studies examining the comparative pathogenesis of melioidosis in regards to the route of infection are generally lacking, particularly in naturally affected species. A goat model was selected as it provides the opportunity to study the importance of the route of infection and its effect on disease pathogenesis in a naturally affected species. Disease and outcome can be evaluated relative to natural presentations in both human and goat populations as goats and humans exhibit a similar epizootiology/epidemiology of melioidosis, which corresponds to similar environmental exposure to B. pseudomallei within its endemic range. Furthermore, the larger body size of goats allows for human-relevant clinical monitoring as well as longer-term serial evaluation of disease progression and therapy in individual animals. Using a caprine model system, we have investigated the pathogenesis of infection following intratracheal aerosol and percutaneous exposure to 104 delivered colony forming units (CFU) of B. pseudomallei. Disease was observed in all animals following infection. Acute disease was more severe in aerosol infected goats, but both groups tended to develop subacute to chronic active disease, with percutaneously infected goats showing regression of lesions at the later time points. Percutaneously infected goats generally exhibited more variable clinical signs, hematologic changes, and gross pathology, but often had histologic lesions with more severe changes. Dissemination from the site of infection was much more rapid in the percutaneously infected animals, with bacteria detectable in the lungs and spleen as early as Day 2 post-infection (PI) and gross abscessation evident in distant sites as early as Day 7 PI. Extrapulmonary dissemination after aerosol infection appeared to occur around Day 7 with splenic or renal abscesses not grossly detectable until day 14. Lesion development was closely associated with a leukocytoclastic vasculitis observed in affected tissues in both aerosol and percutaneous infection. Pulmonary involvement was evident in all but one percutaneously infected goat (Day 2 PI) by culture or the presence of histologic lesions. The rapid dissemination of B. pseudomallei after percutaneous inoculation challenges the perception… Advisors/Committee Members: Bowen, Richard A. (advisor), Aboellail, Tawfik A. (committee member), Dow, Steven S. (committee member), Schweizer, Herbert P. (committee member), Van Metre, David C. (committee member).

Subjects/Keywords: animal model; pseudomallei; percutaneous; melioidosis; pathogenesis; aerosol

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Soffler, C. (2012). Development and characterization of caprine infection models of melioidosis, The. (Doctoral Dissertation). Colorado State University. Retrieved from http://hdl.handle.net/10217/71589

Chicago Manual of Style (16^th Edition):

Soffler, Carl. “Development and characterization of caprine infection models of melioidosis, The.” 2012. Doctoral Dissertation, Colorado State University. Accessed February 28, 2021. http://hdl.handle.net/10217/71589.

MLA Handbook (7^th Edition):

Soffler, Carl. “Development and characterization of caprine infection models of melioidosis, The.” 2012. Web. 28 Feb 2021.

Vancouver:

Soffler C. Development and characterization of caprine infection models of melioidosis, The. [Internet] [Doctoral dissertation]. Colorado State University; 2012. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10217/71589.

Council of Science Editors:

Soffler C. Development and characterization of caprine infection models of melioidosis, The. [Doctoral Dissertation]. Colorado State University; 2012. Available from: http://hdl.handle.net/10217/71589

University of Adelaide

17. Lett, Bron Douglas. [EMBARGOED] Mesenchymal stem cells in an ovine model of kidney transplantation.

Degree: 2018, University of Adelaide

URL: http://hdl.handle.net/2440/120861

► Mesenchymal stem cells (MSCs) have the potential to address current issues in transplantation with their immunosuppressive and regenerative abilities. MSCs as a therapy to improve… (more)

▼ Mesenchymal stem cells (MSCs) have the potential to address current issues in transplantation with their immunosuppressive and regenerative abilities. MSCs as a therapy to improve kidney transplant outcomes have already been taken to the clinical trial stage. The results of these trials have, unfortunately, been disappointing with no significant improvements seen over current transplant outcomes. A return to basic science will help to answer many of the questions surrounding the best methods for the use of MSCs in transplantation medicine. To this end this thesis has set out to examine the application of MSCs in a sheep model of heterotopic kidney transplantation. Chapter 3 describes the isolation, characterisation, and labelling of MSCs with a superparamagnetic iron oxide (SPIO) nano particle that can be used to track the cells using MRI and Prussian blue staining. Importantly, labelling the cells with the SPIO did not have an impact on their phenotype or function. In Chapter 5, the SPIO-MSCs then had their migration tracked when delivered systemically in a sheep kidney autotransplantation model, the development of which is described in chapter 4. The observations indicated the cells passed through the transplanted kidney at 15 minutes post administration but had dispersed by 30 minutes. Upon histological study, significantly more cells had been found to localize to the transplanted kidney than to the native kidney. Lastly, chapter 6 details the effects of MSCs delivered into the artery of kidney allografts. Looking at the creatinine, urea, and kim-1 levels of sheep early after transplantation and later undergoing rejection, gave suggestions that MSCs could reduce kim-1 levels soon after transplantation and may reduce some aspects of rejection. Additionally, the MSCs did not negatively impact the transplanted kidney, demonstrating the safety of delivering the cells arterially. Advisors/Committee Members: Coates, Toby (advisor), Drogemuller, Chris (advisor), Adelaide Medical School (school).

Subjects/Keywords: Stem cells; kidney transplantation; animal model

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APA (6^th Edition):

Lett, B. D. (2018). [EMBARGOED] Mesenchymal stem cells in an ovine model of kidney transplantation. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/120861

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lett, Bron Douglas. “[EMBARGOED] Mesenchymal stem cells in an ovine model of kidney transplantation.” 2018. Thesis, University of Adelaide. Accessed February 28, 2021. http://hdl.handle.net/2440/120861.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lett, Bron Douglas. “[EMBARGOED] Mesenchymal stem cells in an ovine model of kidney transplantation.” 2018. Web. 28 Feb 2021.

Vancouver:

Lett BD. [EMBARGOED] Mesenchymal stem cells in an ovine model of kidney transplantation. [Internet] [Thesis]. University of Adelaide; 2018. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/2440/120861.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lett BD. [EMBARGOED] Mesenchymal stem cells in an ovine model of kidney transplantation. [Thesis]. University of Adelaide; 2018. Available from: http://hdl.handle.net/2440/120861

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

AUT University

18. Al-Rawi, Mohammad. Computational fluid dynamic modelling for arterial diseases assessment .

Degree: 2013, AUT University

URL: http://hdl.handle.net/10292/5202

► One of the leading causes of death is cardiovascular disease, being 30% of all deaths worldwide and 40% of those in New Zealand. In other… (more)

▼ One of the leading causes of death is cardiovascular disease, being 30% of all deaths worldwide and 40% of those in New Zealand. In other words, every 90 minutes a New Zealander dies due to cardiovascular disease. Cardiovascular mortality is higher in New Zealand than Australia, but the reasons for this are not clear. Although Australia and New Zealand are similar politically, culturally, and socioeconomically, mortality from cardiovascular disease is about 25% higher in New Zealand than in Australia. In recent years, engineers and scientists have collaborated with the medical community to find new methods and approaches for assessing and investigating the development of cardiovascular diseases such as abdominal aortic aneurysm and atherosclerosis. In this thesis, atherosclerosis and aneurysm diseases are investigated and analysed using computational fluid dynamic/finite element (CFD/FE) methods. These models are validated against the in vivo and in vitro experiments performed on animals. The experimental models are also investigated; the assessment of arterial blockages using blood pressure waveforms obtained invasively at the right femoral artery. The animal experiments are performed following appropriate ethical protocols (R915) on Wistar rats weighing between 250-350g. An arterial blockage is created surgically within the abdominal aorta of healthy animals to create an unhealthy condition. Blood pressure waveforms are measured by injecting catheter into the right femoral artery of the rat. These measurements are taken at the baseline (healthy condition) and at four different severities of arterial blockage of the abdominal aorta for the same specimen. In vivo and in vitro measurements of the arterial diameter and wall thickness are also taken using Magnetic Resonance Imaging (MRI) and microscopic techniques, respectively. These data are then input onto CFD/FE models in order to develop a new, non-invasive method of assessing arterial blockage. The experimental and computational results indicate that arterial blockages occurring within the abdominal aorta could be assessed, and the development of the disease diagnosed, very clearly and non-invasively at the right femoral artery. The findings of the animal model are then implemented in the human model for screening atherosclerosis and aneurysm at the brachial artery. These diseases are modelled and simulated in a 3D CFD/FE aorta geometry using the fluid–structure interaction (FSI) approach on the commercial software ANSYS®14.0. Literature blood flow waveform datum is assumed at the inlet and invasive catheter pulsatile pressure waveforms data is imposed at the four outlets of the aorta (provided by Green Lane Hospital under ethic approval number NTX/09/11/109). Correlations between the stress phase angle (SPA), augmentation index (AI), lumen diameter and blood pressure waveforms for various scenarios of diseased models are made and compared to the control model. The results show that CFD/FE models with different radii and thicknesses at the abdominal… Advisors/Committee Members: Al-Jumaily, Ahmed (advisor), Lowe, Andrew (advisor).

Subjects/Keywords: CFD/FE; Animal model; Arterial diseases

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APA (6^th Edition):

Al-Rawi, M. (2013). Computational fluid dynamic modelling for arterial diseases assessment . (Thesis). AUT University. Retrieved from http://hdl.handle.net/10292/5202

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Al-Rawi, Mohammad. “Computational fluid dynamic modelling for arterial diseases assessment .” 2013. Thesis, AUT University. Accessed February 28, 2021. http://hdl.handle.net/10292/5202.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Al-Rawi, Mohammad. “Computational fluid dynamic modelling for arterial diseases assessment .” 2013. Web. 28 Feb 2021.

Vancouver:

Al-Rawi M. Computational fluid dynamic modelling for arterial diseases assessment . [Internet] [Thesis]. AUT University; 2013. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10292/5202.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Al-Rawi M. Computational fluid dynamic modelling for arterial diseases assessment . [Thesis]. AUT University; 2013. Available from: http://hdl.handle.net/10292/5202

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oxford

19. Coutinho, Maria Ester Freitas Barbosa Pereira. Central nervous system autoimmunity in neuropsychiatric disorders.

Degree: PhD, 2016, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:389fb830-4b4e-4201-9965-19acb2c63ff3 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.729904

► The recent history of autoimmune neurology is marked by the discovery of many central nervous system (CNS) antibody-mediated diseases. These disorders are caused by antibodies… (more)

Subjects/Keywords: 616.8; Neuroimmunology; Neurodevelopmental disorders; Autoantibodies; animal model

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APA (6^th Edition):

Coutinho, M. E. F. B. P. (2016). Central nervous system autoimmunity in neuropsychiatric disorders. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:389fb830-4b4e-4201-9965-19acb2c63ff3 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.729904

Chicago Manual of Style (16^th Edition):

Coutinho, Maria Ester Freitas Barbosa Pereira. “Central nervous system autoimmunity in neuropsychiatric disorders.” 2016. Doctoral Dissertation, University of Oxford. Accessed February 28, 2021. http://ora.ox.ac.uk/objects/uuid:389fb830-4b4e-4201-9965-19acb2c63ff3 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.729904.

MLA Handbook (7^th Edition):

Coutinho, Maria Ester Freitas Barbosa Pereira. “Central nervous system autoimmunity in neuropsychiatric disorders.” 2016. Web. 28 Feb 2021.

Vancouver:

Coutinho MEFBP. Central nervous system autoimmunity in neuropsychiatric disorders. [Internet] [Doctoral dissertation]. University of Oxford; 2016. [cited 2021 Feb 28]. Available from: http://ora.ox.ac.uk/objects/uuid:389fb830-4b4e-4201-9965-19acb2c63ff3 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.729904.

Council of Science Editors:

Coutinho MEFBP. Central nervous system autoimmunity in neuropsychiatric disorders. [Doctoral Dissertation]. University of Oxford; 2016. Available from: http://ora.ox.ac.uk/objects/uuid:389fb830-4b4e-4201-9965-19acb2c63ff3 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.729904

University of Manchester

20. Oladipo, Joanna. The development and validation of a maternal immune activation (mIA) animal model relevant to neurodevelopmental disorders : a focus towards Autism Spectrum Disorder (ASD).

Degree: PhD, 2018, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/the-development-and-validation-of-a-maternal-immune-activation-mia-animal-model-relevant-to-neurodevelopmental-disorders-a-focus-towards-autism-spectrum-disorder-asd(aa39ca74-6972-430f-83d1-e77e0a1418c5).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.771375

► Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder (NDD) which, despite much research, is not well understood. The heterogeneity of ASD patient cohorts supports… (more)

▼ Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder (NDD) which, despite much research, is not well understood. The heterogeneity of ASD patient cohorts supports the hypothesis of complex interactions of genetic and environmental mechanisms in its aetiology and severity. The presence of gastrointestinal (GI) disturbances in ASD patients that disrupt the bi-directional signalling of the gut-brain axis, suggest that this may play a role in the manifestation of ASD phenotypes. There is also accumulating evidence for the role of neuroinflammatory processes, in both pregnant mother and affected offspring, in the aetiology of NDDs. The increased risk of ASD following infection during pregnancy highlights maternal immune activation (mIA) as a key animal model for NDDs (notably for schizophrenia and ASD) where relevant behavioural phenotypes manifest in the offspring of mIA dams. ASD remains a poorly managed NDD, with no evidence-based therapies for prevention or treatment currently available. Validating new mIA models and refining current methods is vital to the development of new therapeutic strategies. This thesis has explored the development of an mIA model to test the maternal infection hypothesis using exposure to the viral mimetic polyinosinic-polycytidylic acid (poly (I:C)) administered mid-way through pregnancy (gestational day (GD) 12.5) in rats. First, the acute effects of poly (I:C) in non-pregnant female rats were investigated, providing a validation of the experimental methods (strain, route of administration and dose). Separate cohorts of Wistar rats were then used in the GD12.5 mIA model and the physiological responses to 10 mg/kg i.p. poly (I:C) measured. Various measures including elevation of plasma IL-6 and changes in core body temperature were found to be variable between treated dams. These results confirmed the need to standardise analysis of mIA in dams, to correlate maternal inflammation with subsequent offspring outcomes such as phenotype and neuronal development changes. Poly (I:C) batch differences were also thought to contribute to these variable results and refinement of mIA methods are proposed. Longitudinal effects of mIA on offspring of both sexes were investigated including their developmental trajectory measuring specific gene expression, morphology at GD21 and post-natal day (PD) 21, and behavioural phenotyping at adolescence and adulthood. Gestational and early postnatal changes in offspring following mIA have yet to be systematically explored. Gene expression analysis at GD21 and PD21 in offspring shows that this mIA model is useful for the identification of early developmental changes relevant to NDDs. Moreover, analysis of gene expression changes related to synaptic function, glial cells and blood-brain barrier integrity demonstrated that changes were dependent on both sex and brain region of interest. This confirms the need to include both sexes of offspring and inclusion of different brain regions for analysis which is a common limitation of previous preclinical…

Subjects/Keywords: 610; animal model; neurodevelopmental; maternal immune activation

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APA (6^th Edition):

Oladipo, J. (2018). The development and validation of a maternal immune activation (mIA) animal model relevant to neurodevelopmental disorders : a focus towards Autism Spectrum Disorder (ASD). (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/the-development-and-validation-of-a-maternal-immune-activation-mia-animal-model-relevant-to-neurodevelopmental-disorders-a-focus-towards-autism-spectrum-disorder-asd(aa39ca74-6972-430f-83d1-e77e0a1418c5).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.771375

Chicago Manual of Style (16^th Edition):

Oladipo, Joanna. “The development and validation of a maternal immune activation (mIA) animal model relevant to neurodevelopmental disorders : a focus towards Autism Spectrum Disorder (ASD).” 2018. Doctoral Dissertation, University of Manchester. Accessed February 28, 2021. https://www.research.manchester.ac.uk/portal/en/theses/the-development-and-validation-of-a-maternal-immune-activation-mia-animal-model-relevant-to-neurodevelopmental-disorders-a-focus-towards-autism-spectrum-disorder-asd(aa39ca74-6972-430f-83d1-e77e0a1418c5).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.771375.

MLA Handbook (7^th Edition):

Oladipo, Joanna. “The development and validation of a maternal immune activation (mIA) animal model relevant to neurodevelopmental disorders : a focus towards Autism Spectrum Disorder (ASD).” 2018. Web. 28 Feb 2021.

Vancouver:

Oladipo J. The development and validation of a maternal immune activation (mIA) animal model relevant to neurodevelopmental disorders : a focus towards Autism Spectrum Disorder (ASD). [Internet] [Doctoral dissertation]. University of Manchester; 2018. [cited 2021 Feb 28]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/the-development-and-validation-of-a-maternal-immune-activation-mia-animal-model-relevant-to-neurodevelopmental-disorders-a-focus-towards-autism-spectrum-disorder-asd(aa39ca74-6972-430f-83d1-e77e0a1418c5).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.771375.

Council of Science Editors:

Oladipo J. The development and validation of a maternal immune activation (mIA) animal model relevant to neurodevelopmental disorders : a focus towards Autism Spectrum Disorder (ASD). [Doctoral Dissertation]. University of Manchester; 2018. Available from: https://www.research.manchester.ac.uk/portal/en/theses/the-development-and-validation-of-a-maternal-immune-activation-mia-animal-model-relevant-to-neurodevelopmental-disorders-a-focus-towards-autism-spectrum-disorder-asd(aa39ca74-6972-430f-83d1-e77e0a1418c5).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.771375

21. Duprez, Jessica Anais Sybille. Experimental vaccination for onchocerciasis and the identification of early markers of protective immunity.

Degree: PhD, 2018, University of Edinburgh

URL: http://hdl.handle.net/1842/28976

► Onchocerciasis, caused by Onchocerca volvulus remains a major public health and socio-economic problem across the tropics, despite years of mass drug administration (MDA) with Ivermectin… (more)

▼ Onchocerciasis, caused by Onchocerca volvulus remains a major public health and socio-economic problem across the tropics, despite years of mass drug administration (MDA) with Ivermectin to reduce disease burden. Through modelling, it has been shown that elimination cannot be achieved with MDA alone and additional tools are needed, such as vaccination, which remains the most cost-effective tool for long-term disease control. The feasibility behind vaccination against O. volvulus can be demonstrated in the Litomosoides sigmodontis mouse model, which shows that vaccine induced protection can be achieved with immunisation using irradiated L3, the infective stage of L. sigmodontis and with microfilariae (Mf), the transmission stage of the parasite. There is further evidence of protective immunity in humans, with individuals living in endemic areas that show no signs of infection despite being exposed to the parasite (endemic normal). The protective efficacy of promising vaccine candidates were evaluated using an immunisation time course in the L. sigmodontis model, using either DNA plasmid or peptide vaccines. In immunisation experiments in L. sigmodontis, Mf numbers are used as a measure of protection and marks the end of an immunisation time course. However, when changes in gene expression were measured at the end of an immunisation time course, in attempts to identify gene signatures that could be used as markers of protection (correlates of protection) in the blood, no gene signatures were found to be associated with protection. This suggest that at the end of an immunisation time course, when protection is measured (change in Mf numbers), it is too late in infection to measure changes in immune pathways being triggered. Changes in gene expression were therefore measured in blood samples collected throughout an immunisation time course in the L. sigmodontis model, in order to identify the time point in an immunisation experiment which are the most indicative of protection. Two independent immunisation time courses were used, either using irradiated L3 or Mf as vaccine against L. sigmodontis, as these elicit the greatest protection. This generated a large high dimensional dataset, that was too large and complex for a differential fold-change analysis. Therefore, an analysis pipeline was created using machine learning algorithms, to detect changes in gene expression throughout the time courses to detect markers of protection. The 6 hour time point following immunisation showed the greatest change in gene expression, with the analysis pipeline identifying known pathways associated with vaccine-induced immunity. The pipeline was applied to gene expression data from human samples obtained from individuals living in endemic areas who were either infected with O. volvulus or endemic normal (naturally protected), this was to identify pathways associated with protective immunity in humans. When comparing vaccine induced immunity seen in mice and natural protective immunity in humans there was some overlap in pathways being…

Subjects/Keywords: onchocerciasis; river blindness; vaccination time; animal model

12 more images…

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APA (6^th Edition):

Duprez, J. A. S. (2018). Experimental vaccination for onchocerciasis and the identification of early markers of protective immunity. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/28976

Chicago Manual of Style (16^th Edition):

Duprez, Jessica Anais Sybille. “Experimental vaccination for onchocerciasis and the identification of early markers of protective immunity.” 2018. Doctoral Dissertation, University of Edinburgh. Accessed February 28, 2021. http://hdl.handle.net/1842/28976.

MLA Handbook (7^th Edition):

Duprez, Jessica Anais Sybille. “Experimental vaccination for onchocerciasis and the identification of early markers of protective immunity.” 2018. Web. 28 Feb 2021.

Vancouver:

Duprez JAS. Experimental vaccination for onchocerciasis and the identification of early markers of protective immunity. [Internet] [Doctoral dissertation]. University of Edinburgh; 2018. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1842/28976.

Council of Science Editors:

Duprez JAS. Experimental vaccination for onchocerciasis and the identification of early markers of protective immunity. [Doctoral Dissertation]. University of Edinburgh; 2018. Available from: http://hdl.handle.net/1842/28976

University of Gothenburg / Göteborgs Universitet

22. Bian, Li. The role of S100A4 protein as a regulator of inflammation and bone metabolism in experimental arthritis.

Degree: 2011, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/26277

► S100A4 belongs to the family of calcium-binding S100 proteins and modulates cell proliferation, cytoskeletal rearrangement, cell motility, and angiogenesis. Increased levels of S100A4 expression correlate… (more)

▼ S100A4 belongs to the family of calcium-binding S100 proteins and modulates cell proliferation, cytoskeletal rearrangement, cell motility, and angiogenesis. Increased levels of S100A4 expression correlate with high incidence of metastasis of cancers. Up-regulation of S100A4 protein is demonstrated in synovial tissue and in plasma of rheumatoid arthritis (RA) patients compared with osteoarthritis, and the elevated expression of S100A4 is associated with increased disease activity in patients with RA. Dichloroacetate (DCA) was shown to have a potent anti-tumour effect by facilitating apoptosis and inhibiting proliferation. The aims of this thesis are to investigate contributions of S100A4 in experimental models of septic arthritis and antigen-induced arthritis, and in bone formation using S100A4KO mice. In addition, we also aim to find out the impact of DCA on collagen type II-induced arthritis. Our studies showed that S100A4 deficiency resulted in reduced joint inflammation and cartilage/bone destruction in both septic and antigen-induced arthritis in mice. Additionally, in septic arthritis, S100A4KO mice had less bone loss and showed a lower bacterial load in the kidneys. S100A4 deficiency resulted in changed pattern of adhesion molecules. In antigen-induced arthritis, S100A4 deficiency resulted in reduced intensity of arthritis and significantly lower frequency of bone destruction, supported by fewer numbers of CD4+ T cells and CD19+CD5+ B cells accumulated in synovia and spleen compared with WT mice. Smaller populations of CD4+ and CD8+ T cells in spleen of S100A4 deficient mice were accompanied by reduced productions of INF-γ and IL-17A, and lower expression of Th17 transcription factor RORγt. Difference in the severity of arthritis was observed in female mice in septic arthritis and in male mice in antigen-induced arthritis. To assess the role of sex hormone on bone, we analysed BMD in S100A4KO and WT mice. S100A4KO mice had higher total BMD and female mice displayed more cortical bone content compared with WT mice. Following ovariectomy (OVX), both S100A4KO and WT mice lost BMD. However, cortical bone loss was more pronounced in S100A4KO mice than in WT supported by high CTX-I level. The loss of trabecular bone was similar in S100A4KO and WT mice. DHEA treatment resulted in a significant increase in the trabecular and cortical BMD both in WT and S100A4KO mice. This increase of BMD was lower in S100A4KO mice. The collagen-type II arthritis model was employed to study the potential effect of dichloroacetate (DCA) treatment on experimental arthritis. Our results showed that mice treated with DCA had a slower onset of CIA, and significantly lower severity and frequency of joint inflammation and cartilage/bone destruction compared with water-treated controls. Moreover, DCA prevented arthritis-induced loss of cortical mineral density. The beneficial effect of DCA was present only in female DBA/1 mice. DCA treatment on the OVX mice did not protect from the development of arthritis, indicating that effect of DCA is…

Subjects/Keywords: S100A4; arthritis; animal model; bone; inflammation

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APA (6^th Edition):

Bian, L. (2011). The role of S100A4 protein as a regulator of inflammation and bone metabolism in experimental arthritis. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/26277

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bian, Li. “The role of S100A4 protein as a regulator of inflammation and bone metabolism in experimental arthritis.” 2011. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed February 28, 2021. http://hdl.handle.net/2077/26277.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bian, Li. “The role of S100A4 protein as a regulator of inflammation and bone metabolism in experimental arthritis.” 2011. Web. 28 Feb 2021.

Vancouver:

Bian L. The role of S100A4 protein as a regulator of inflammation and bone metabolism in experimental arthritis. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2011. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/2077/26277.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bian L. The role of S100A4 protein as a regulator of inflammation and bone metabolism in experimental arthritis. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2011. Available from: http://hdl.handle.net/2077/26277

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Salmeto-Johnson, Amy L. Measurement Of Anhedonia In The Chick Anxiety-Depression Model.

Degree: PhD, Psychology, 2014, University of Mississippi

URL: https://egrove.olemiss.edu/etd/838

► Anhedonia, the loss of pleasure in previously pleasurable activities, is one of the cardinal features of depression. To further validate the chick anxiety-depression model, the… (more)

▼ Anhedonia, the loss of pleasure in previously pleasurable activities, is one of the cardinal features of depression. To further validate the chick anxiety-depression model, the current study aimed at quantifying anhedonia as well its reversal with pharmaceuticals. The first goal was to identify a measure to quantify the display of anhedonia in chicks following exposure to an isolation stressor, the chick anxiety-depression model. All experiments involved a baseline and test measurement either after removal from the home cage (No Test) or exposure to the isolation apparatus with conspecifics and mirrors (Social) or individually (Isolated). Experiment 1 used a straight maze with start and goal latency serving as the dependent measures. Isolated chicks expressed delays in start latency compared to No Test chicks, which is interpreted as anhedonia-like behavior. Experiment 2 used a modified sucrose preference task to assess sucrose preference and the number of drinking events for water and sucrose. Consistent with the rodent literature, results showed decreased sucrose preference in Isolated chicks compared to No Test chicks. Experiment 3 involved measurement of behavior in a dust bath apparatus. Contrary to predictions, limited behavior was observed in the apparatus. The second goal of the present study was to be able to reverse the display of anhedonia-like behavior, as measured in the straight alley maze, with pharmaceutical manipulation. Experiment 4 involved administration of vehicle, 10 or 15 mg/kg Imipramine prior to exposure to the isolation apparatus followed by testing in the straight alley maze. Both 10 and 15 mg/kg Imipramine were shown to alleviate the onset of behavioral despair in the isolation test. The 15 mg/kg Imipramine dose also alleviated the display of anhedonia in the straight alley maze. Experiment 5 involved the administration of vehicle, 5 or 10 mg/kg Ketamine prior to exposure to the isolation apparatus followed by testing in the straight alley maze. Neither 5 nor 10 mg/kg Ketamine were able to alleviate the onset of behavioral despair or anhedonia as assessed in the straight alley maze. Advisors/Committee Members: Michael T. Allen, S. Narasimha Murthy, Michael T. Allen.

Subjects/Keywords: Anhedonia; Animal; Chick; Depression; Model; Psychology

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APA (6^th Edition):

Salmeto-Johnson, A. L. (2014). Measurement Of Anhedonia In The Chick Anxiety-Depression Model. (Doctoral Dissertation). University of Mississippi. Retrieved from https://egrove.olemiss.edu/etd/838

Chicago Manual of Style (16^th Edition):

Salmeto-Johnson, Amy L. “Measurement Of Anhedonia In The Chick Anxiety-Depression Model.” 2014. Doctoral Dissertation, University of Mississippi. Accessed February 28, 2021. https://egrove.olemiss.edu/etd/838.

MLA Handbook (7^th Edition):

Salmeto-Johnson, Amy L. “Measurement Of Anhedonia In The Chick Anxiety-Depression Model.” 2014. Web. 28 Feb 2021.

Vancouver:

Salmeto-Johnson AL. Measurement Of Anhedonia In The Chick Anxiety-Depression Model. [Internet] [Doctoral dissertation]. University of Mississippi; 2014. [cited 2021 Feb 28]. Available from: https://egrove.olemiss.edu/etd/838.

Council of Science Editors:

Salmeto-Johnson AL. Measurement Of Anhedonia In The Chick Anxiety-Depression Model. [Doctoral Dissertation]. University of Mississippi; 2014. Available from: https://egrove.olemiss.edu/etd/838

East Tennessee State University

24. Hernandez, Liza. Alcohol Consumption in a Preclinical Model of Schizophrenia.

Degree: MA, Psychology, 2020, East Tennessee State University

URL: https://dc.etsu.edu/etd/3693

► Schizophrenia is a debilitating psychiatric disorder that affects approximately 1% of the global population. Schizophrenia is highly comorbid with other psychiatric disorders such as… (more)

Subjects/Keywords: Schizophrenia; Alcohol; Quinpirole; Animal Model; Behavioral Neurobiology

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APA (6^th Edition):

Hernandez, L. (2020). Alcohol Consumption in a Preclinical Model of Schizophrenia. (Thesis). East Tennessee State University. Retrieved from https://dc.etsu.edu/etd/3693

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hernandez, Liza. “Alcohol Consumption in a Preclinical Model of Schizophrenia.” 2020. Thesis, East Tennessee State University. Accessed February 28, 2021. https://dc.etsu.edu/etd/3693.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hernandez, Liza. “Alcohol Consumption in a Preclinical Model of Schizophrenia.” 2020. Web. 28 Feb 2021.

Vancouver:

Hernandez L. Alcohol Consumption in a Preclinical Model of Schizophrenia. [Internet] [Thesis]. East Tennessee State University; 2020. [cited 2021 Feb 28]. Available from: https://dc.etsu.edu/etd/3693.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hernandez L. Alcohol Consumption in a Preclinical Model of Schizophrenia. [Thesis]. East Tennessee State University; 2020. Available from: https://dc.etsu.edu/etd/3693

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Colorado State University

25. Layer, Emily L. Understanding Mycobacterium abscessus pulmonary and disseminated disease.

Degree: MS(M.S.), Microbiology, Immunology, and Pathology, 2017, Colorado State University

URL: http://hdl.handle.net/10217/183863

► Mycobacterium abscessus is an emerging human pathogen which is difficult to treat and results in increased mortality. Moreover, the cause of increasing case rates and… (more)

▼ Mycobacterium abscessus is an emerging human pathogen which is difficult to treat and results in increased mortality. Moreover, the cause of increasing case rates and also the pathogenesis of M. abscessus are poorly understood. M. abscessus belongs to the family of nontuberculous mycobacteria (NTM) classified as members of the rapidly growing mycobacteria (RGM). These environmental pathogens are ubiquitous and found in shower heads, tap water, natural water sources, and soil. Humans contract pulmonary or disseminated infections with M. abscessus by breathing in the aerosolized bacteria or ingesting contaminated water. Immunocompromised individuals such as HIV or AIDS patients, are more susceptible to infection with M. abscessus as are those with cystic fibrosis, bronchiectasis, and individuals on tumor necrosis factor α (TNFα) inhibitors. Strangely, an increasing population of patients becoming infected with M. abscessus are immunocompetent, tall, slender, Caucasian, non-smoking women. To expand our understanding of M. abscessus pathogenesis we developed mouse models that maintain high levels of bacterial infection to study immune responses induced by clinical strains of M. abscessus. Our results support the hypothesis that this bacteria can only persist in our animal models that possess a deficiency in macrophages and T cell function. Clustered bacterial strains obtained from Cystic Fibrosis patients are more virulent than unclustered bacterial strains obtained from Cystic Fibrosis patients. Additionally, counts of viable mycobacterial colony forming units and histological analysis in (Severe Combined Immunodeficiency) SCID mice on a beige background infected with clustered versus unclustered M. abscessus strains which were isolated from Cystic Fibrosis patients also supported the increased virulence exhibited by the clustered strains. Lastly, we show that major human M. abscessus outbreak strains, when infecting IL-3, GM-CSF deficient mice on an IL-2, Rag2 deficient background (GM/Rag-dblKO mice), result in increased bacterial replication and organ pathology and impaired protective immunity against this pathogen. Advisors/Committee Members: Ordway, Diane (advisor), Orme, Ian (committee member), Chatterjee, Delphi (committee member), Kirby, Michael (committee member).

Subjects/Keywords: animal; mouse; nontuberculous; model; abscessus; mycobacteria

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APA (6^th Edition):

Layer, E. L. (2017). Understanding Mycobacterium abscessus pulmonary and disseminated disease. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/183863

Chicago Manual of Style (16^th Edition):

Layer, Emily L. “Understanding Mycobacterium abscessus pulmonary and disseminated disease.” 2017. Masters Thesis, Colorado State University. Accessed February 28, 2021. http://hdl.handle.net/10217/183863.

MLA Handbook (7^th Edition):

Layer, Emily L. “Understanding Mycobacterium abscessus pulmonary and disseminated disease.” 2017. Web. 28 Feb 2021.

Vancouver:

Layer EL. Understanding Mycobacterium abscessus pulmonary and disseminated disease. [Internet] [Masters thesis]. Colorado State University; 2017. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10217/183863.

Council of Science Editors:

Layer EL. Understanding Mycobacterium abscessus pulmonary and disseminated disease. [Masters Thesis]. Colorado State University; 2017. Available from: http://hdl.handle.net/10217/183863

University of Melbourne

26. Senesi, Matteo. Behavioural characterization of M1000 prion strain pathogenesis and the acute neurotoxicity of disease-associated prion protein in vivo.

Degree: 2015, University of Melbourne

URL: http://hdl.handle.net/11343/91119

► Prion diseases are a group of transmissible, fatal, neurodegenerative diseases naturally afflicting a number of mammals, including humans and no effective treatments currently exist. The… (more)

▼ Prion diseases are a group of transmissible, fatal, neurodegenerative diseases naturally afflicting a number of mammals, including humans and no effective treatments currently exist. The most common human prion disease phenotype is Creutzfeldt-Jakob disease (CJD), which is quite rare, occurring at a rate of around 1-2 per million per year, with other forms of human prion disease such as iatrogenic CJD, Gerstmann-Sträussler-Scheinker syndrome (GSS) and fatal familial insomnia (FFI) much less common. Kuru, as well, a prion disease endemic to the Fore linguistic group in the Eastern Highlands of New Guinea, is now most likely extinct stemming from the effective outlawing of cannibalistic mourning rituals amongst these natives. Although rare, concerns around inter- and intra-species transmissibility generally give prion diseases a heightened profile, especially when dealing with health care settings. The central pathogenic event in prion disease is understood to be the misfolding of the normal or cellular form of the prion protein (PrPc) into a β-strand enriched, disease-causing conformer (PrPSc), which characteristically manifests altered biochemical properties such as detergent insolubility, relative protease resistance and heightened tendency to aggregate. The refolding can be promoted by genetic mutations in the gene encoding PrPc (PRNP) associated with genetic prion disease or occur through a stochastic misfolding event (sporadic prion disease). Once present (including through exogenous introduction), PrPSc propagation proceeds through an auto-catalytic self-templating mechanism, wherein PrPc forms a hetero-dimer with a molecule of PrPSc. The normal function(s) of the glycoprotein PrPc remain unresolved but the protein is ubiquitously expressed with highest levels found in neurons and after a number of post-translational modifications is normally bound through a glycosylphosphatidylinositol anchor to the external cellular surface within lipid rafts. Prions, the infectious unit of prion diseases, are believed to be composed predominantly or exclusively by PrPSc, with host tissue expression of PrPc absolutely essential for successful disease transmission; current evidence suggests that different species of PrPSc may underpin neurotoxicity and transmissibility. The ongoing imperative to develop effective treatments has been pari passu with investigations to better understand the neurotoxic events and pathogenic mechanisms sub-serving prion disease, with the belief that improved mechanistic insights will facilitate development of effective therapies. Of additional interest has been the recent parallel investigations of other common neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, which have identified “prion-like” mechanisms of misfolded protein propagation (through self-templating to generate multimers including soluble oligomers and amyloid fibrils), as well as the inter-cellular spreading mechanisms of misfolded proteins. Consequently, an improved understanding of the mechanisms…

Subjects/Keywords: prion; neuroscience; animal model; fear; learning; memory

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Senesi, M. (2015). Behavioural characterization of M1000 prion strain pathogenesis and the acute neurotoxicity of disease-associated prion protein in vivo. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/91119

Chicago Manual of Style (16^th Edition):

Senesi, Matteo. “Behavioural characterization of M1000 prion strain pathogenesis and the acute neurotoxicity of disease-associated prion protein in vivo.” 2015. Doctoral Dissertation, University of Melbourne. Accessed February 28, 2021. http://hdl.handle.net/11343/91119.

MLA Handbook (7^th Edition):

Senesi, Matteo. “Behavioural characterization of M1000 prion strain pathogenesis and the acute neurotoxicity of disease-associated prion protein in vivo.” 2015. Web. 28 Feb 2021.

Vancouver:

Senesi M. Behavioural characterization of M1000 prion strain pathogenesis and the acute neurotoxicity of disease-associated prion protein in vivo. [Internet] [Doctoral dissertation]. University of Melbourne; 2015. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/11343/91119.

Council of Science Editors:

Senesi M. Behavioural characterization of M1000 prion strain pathogenesis and the acute neurotoxicity of disease-associated prion protein in vivo. [Doctoral Dissertation]. University of Melbourne; 2015. Available from: http://hdl.handle.net/11343/91119

University of Melbourne

27. Battistuzzo, Camila. Recovery of locomotion in mice following spinal cord injury.

Degree: 2014, University of Melbourne

URL: http://hdl.handle.net/11343/51133

► Traumatic spinal cord injury (SCI) is a devastating condition with a worldwide incidence of 10 to 40 cases per million people (Norton 2010). In Australia,… (more)

▼ Traumatic spinal cord injury (SCI) is a devastating condition with a worldwide incidence of 10 to 40 cases per million people (Norton 2010). In Australia, there are approximately 300 to 400 new cases of SCI each year. Over the last 60 years, significant advances in both the acute and rehabilitation management of SCI have resulted in reduced mortality and increased life expectancy. Improvements in the medical care of SCI have also led to an increased proportion of incomplete SCI. These patients generally have some preservation of motor and sensory function; however, achieving functional recovery remains a major challenge for the clinical and research communities. In the early 1980s, the breakthrough finding that repetitive treadmill training restored stepping in spinal cats had a profound impact on the rehabilitation of people with SCI (Lovely et al. 1986). The focus of rehabilitation changed from training compensation strategies to retraining locomotion using activity-based therapies (e.g. treadmill training). Despite many studies in animal models of complete SCI demonstrating the benefits locomotor training on gait recovery, the evidence for the effects of this type of intervention following incomplete SCI remains unclear. Furthermore, questions about the optimal training dosage and timing are yet to be resolved. The overall aim of this thesis was to assess the recovery of locomotion in mice with incomplete SCI. An incomplete model involving a lateral hemisection injury was chosen as it was felt that this would allow assessment of recovery between affected and non-affected hindlimbs and be a sensitive method of detecting training effects. In addition to the experiments detailed in this thesis, included animals also had electrophysiological assessments of the spinal cord neurons (not described in this thesis). The first study of this thesis (Chapter 3) was a systematic review summarizing the evidence of locomotor training after SCI. The results of this review demonstrated that locomotor training in animals after SCI improves locomotion. However, there was significant heterogeneity between studies and the methodological quality of the included studies was often poor. In light of these data, two experimental studies were designed with high methodological standards. In the second (and first experimental) study (Chapter 4), the effects of treadmill training for 3,6 and 9 weeks on recovery of locomotion were assessed in a mouse model of spinal hemisection. A high-speed camera was used to obtain detailed kinematic gait characteristics of animals with and without training. These data demonstrated that treadmill training had a limited effect on the recovery of gait. Subsequently, (Chapter 5), the effect of treadmill training for 3, 6 and 9 weeks on hindlimb muscle properties in hemisected SCI mice was investigated. The results of this study showed that treadmill training was effective in preventing atrophy of fast-twitch muscles (e.g. tibialis anterior) but had limited effects on slow-twitch muscles (e.g.…

Subjects/Keywords: spinal cord injury; exercise; animal model

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Battistuzzo, C. (2014). Recovery of locomotion in mice following spinal cord injury. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/51133

Chicago Manual of Style (16^th Edition):

Battistuzzo, Camila. “Recovery of locomotion in mice following spinal cord injury.” 2014. Doctoral Dissertation, University of Melbourne. Accessed February 28, 2021. http://hdl.handle.net/11343/51133.

MLA Handbook (7^th Edition):

Battistuzzo, Camila. “Recovery of locomotion in mice following spinal cord injury.” 2014. Web. 28 Feb 2021.

Vancouver:

Battistuzzo C. Recovery of locomotion in mice following spinal cord injury. [Internet] [Doctoral dissertation]. University of Melbourne; 2014. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/11343/51133.

Council of Science Editors:

Battistuzzo C. Recovery of locomotion in mice following spinal cord injury. [Doctoral Dissertation]. University of Melbourne; 2014. Available from: http://hdl.handle.net/11343/51133

University of Melbourne

28. Krenus, Charlotte. Models of spontaneous intracerebral haemorrhage in hypertensive rats.

Degree: 2017, University of Melbourne

URL: http://hdl.handle.net/11343/210712

► Few animal models of stroke have created haematomas that mimic the processes seen in humans. We developed a new model of intracerebral haemorrhage (ICH) in… (more)

Subjects/Keywords: intracerebral haemorrhage; stroke; hypertension; animal model; translation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Krenus, C. (2017). Models of spontaneous intracerebral haemorrhage in hypertensive rats. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/210712

Chicago Manual of Style (16^th Edition):

Krenus, Charlotte. “Models of spontaneous intracerebral haemorrhage in hypertensive rats.” 2017. Doctoral Dissertation, University of Melbourne. Accessed February 28, 2021. http://hdl.handle.net/11343/210712.

MLA Handbook (7^th Edition):

Krenus, Charlotte. “Models of spontaneous intracerebral haemorrhage in hypertensive rats.” 2017. Web. 28 Feb 2021.

Vancouver:

Krenus C. Models of spontaneous intracerebral haemorrhage in hypertensive rats. [Internet] [Doctoral dissertation]. University of Melbourne; 2017. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/11343/210712.

Council of Science Editors:

Krenus C. Models of spontaneous intracerebral haemorrhage in hypertensive rats. [Doctoral Dissertation]. University of Melbourne; 2017. Available from: http://hdl.handle.net/11343/210712

University of Hawaii – Manoa

29. Ciraolo, Margeaux Faye. A computational investigation of relational reasoning in nonhuman animals.

Degree: 2016, University of Hawaii – Manoa

URL: http://hdl.handle.net/10125/101253

►

M.A. University of Hawaii at Manoa 2012.

Since Darwin (1859) suggested that all animals share a common ancestry, researchers have attempted to assess how the… (more)

Subjects/Keywords: cognition; animal cognition; computational model; relational reasoning

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ciraolo, M. F. (2016). A computational investigation of relational reasoning in nonhuman animals. (Thesis). University of Hawaii – Manoa. Retrieved from http://hdl.handle.net/10125/101253

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ciraolo, Margeaux Faye. “A computational investigation of relational reasoning in nonhuman animals.” 2016. Thesis, University of Hawaii – Manoa. Accessed February 28, 2021. http://hdl.handle.net/10125/101253.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ciraolo, Margeaux Faye. “A computational investigation of relational reasoning in nonhuman animals.” 2016. Web. 28 Feb 2021.

Vancouver:

Ciraolo MF. A computational investigation of relational reasoning in nonhuman animals. [Internet] [Thesis]. University of Hawaii – Manoa; 2016. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10125/101253.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ciraolo MF. A computational investigation of relational reasoning in nonhuman animals. [Thesis]. University of Hawaii – Manoa; 2016. Available from: http://hdl.handle.net/10125/101253

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. Siemienowicz, Katarzyna Joanna. Fetal programming of adult disease : causes and consequences of metabolic dysregulation in an ovine model of PCOS.

Degree: PhD, 2018, University of Edinburgh

URL: http://hdl.handle.net/1842/28977

► Polycystic ovary syndrome (PCOS) is a common and complex endocrine condition with reproductive and metabolic complications, affecting up to 10% of reproductive-age women. Hyperandrogenemia, ovulatory… (more)

▼ Polycystic ovary syndrome (PCOS) is a common and complex endocrine condition with reproductive and metabolic complications, affecting up to 10% of reproductive-age women. Hyperandrogenemia, ovulatory dysfunction, and luteinising hormone hypersecretion are characteristic traits of PCOS however, it seems that the most concerning long-term key issues are metabolic problems associated with the syndrome, such as hyperinsulinemia, insulin resistance, obesity, dyslipidaemia and non-alcoholic liver disease. Despite the numerous studies on PCOS, its origin and pathophysiology are still not fully understood. However, there is increasing evidence that the adult PCOS phenotype is programmed in fetal life by androgen excess. Exposure to increased levels of testosterone in utero in rodents, sheep and monkeys result in adult reproductive and metabolic pathologies that parallel those seen in PCOS women. Since hyperandrogenemia is a hallmark of PCOS and daughters of PCOS mothers have elevated levels of androgens at birth, it is likely that prenatal androgenisation during early life predispose to the future development of PCOS. Animal models of PCOS provide an opportunity to examine the developmental aetiology and molecular mechanisms underlying the pathogenesis of this condition. Over last 10 years our lab has successfully utilised a well-established ovine model of PCOS, where pregnant ewes were treated with testosterone propionate (TP) through mid-gestation. From this model, we had a large sample bank of fixed and frozen tissues from the fetal, lamb and adolescent prenatally androgenised animals that allowed to carry a broad range of experiments. In addition, a new cohort of prenatally androgenised adult sheep enabled additional in vivo analysis. Past research documented that prenatal androgenisation result in hyperinsulinemia with altered pancreas structure and function, and early fatty liver without difference in body weight in adolescent sheep. This thesis examines the effects and consequences of increased in utero androgen exposure on metabolic dysregulation in adolescent and adult female sheep. During puberty, but not fetal or early life, there was decreased adipogenesis in subcutaneous adipose tissue (SAT), but not visceral adipose tissue (VAT), accompanied by decreased circulating concentrations of fibroblast growth factor 21 (FGF21), leptin and adiponectin, and increased concentrations of fasting free fatty acids (FFA) in prenatally androgenised sheep. This was countered by upregulated expression of FFA transporters in liver. As adults, TP-exposed animals had increased body weight, elevated fasting insulin and FFA concentrations but normal FGF21, leptin and adiponectin levels. Histological analysis revealed that adult TP-exposed animals had SAT hypertrophy, which was associated with increased expression of inflammatory markers and correlated with increased fasting FFA. Therefore, it is likely that impaired preadipocyte differentiation in SAT during adolescence resulted in hypertrophy and inflammation of adult SAT. This…

Subjects/Keywords: polycystic ovary syndrome; PCOS; androgen; animal model

10 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Siemienowicz, K. J. (2018). Fetal programming of adult disease : causes and consequences of metabolic dysregulation in an ovine model of PCOS. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/28977

Chicago Manual of Style (16^th Edition):

Siemienowicz, Katarzyna Joanna. “Fetal programming of adult disease : causes and consequences of metabolic dysregulation in an ovine model of PCOS.” 2018. Doctoral Dissertation, University of Edinburgh. Accessed February 28, 2021. http://hdl.handle.net/1842/28977.

MLA Handbook (7^th Edition):

Siemienowicz, Katarzyna Joanna. “Fetal programming of adult disease : causes and consequences of metabolic dysregulation in an ovine model of PCOS.” 2018. Web. 28 Feb 2021.

Vancouver:

Siemienowicz KJ. Fetal programming of adult disease : causes and consequences of metabolic dysregulation in an ovine model of PCOS. [Internet] [Doctoral dissertation]. University of Edinburgh; 2018. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1842/28977.

Council of Science Editors:

Siemienowicz KJ. Fetal programming of adult disease : causes and consequences of metabolic dysregulation in an ovine model of PCOS. [Doctoral Dissertation]. University of Edinburgh; 2018. Available from: http://hdl.handle.net/1842/28977

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Open Access Theses and Dissertations