subject:(Mitochondrial metals)

The Ohio State University

1. Hwang, Kou Mau. The effect of heavy metals on the permeability of the mitochondrial membrane and its energy-linked reactions.

Degree: PhD, Graduate School, 1972, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486733043936193

Subjects/Keywords: Chemistry; Metals; Mitochondrial membranes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hwang, K. M. (1972). The effect of heavy metals on the permeability of the mitochondrial membrane and its energy-linked reactions. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1486733043936193

Chicago Manual of Style (16^th Edition):

Hwang, Kou Mau. “The effect of heavy metals on the permeability of the mitochondrial membrane and its energy-linked reactions.” 1972. Doctoral Dissertation, The Ohio State University. Accessed January 20, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486733043936193.

MLA Handbook (7^th Edition):

Hwang, Kou Mau. “The effect of heavy metals on the permeability of the mitochondrial membrane and its energy-linked reactions.” 1972. Web. 20 Jan 2021.

Vancouver:

Hwang KM. The effect of heavy metals on the permeability of the mitochondrial membrane and its energy-linked reactions. [Internet] [Doctoral dissertation]. The Ohio State University; 1972. [cited 2021 Jan 20]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486733043936193.

Council of Science Editors:

Hwang KM. The effect of heavy metals on the permeability of the mitochondrial membrane and its energy-linked reactions. [Doctoral Dissertation]. The Ohio State University; 1972. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486733043936193

2. Han, Thi-Hong-Liên. Etudes de la fonction de la frataxine : relations avec l'homéostasie métallique et le stress oxydant. : Functional studies of Frataxin : relations with metal homeostasis and oxidatives stress.

Degree: Docteur es, Chimie. Physico-Chimie, 2016, Sorbonne Paris Cité

URL: http://www.theses.fr/2016USPCC288

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La frataxine est une protéine mitochondriale bien conservée de la bactérie à l’homme. La déficience de la frataxine chez l’homme entraine une maladie neurodégénérative grave,… (more)

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La frataxine est une protéine mitochondriale bien conservée de la bactérie à l’homme. La déficience de la frataxine chez l’homme entraine une maladie neurodégénérative grave, appelée Ataxie de Friedreich. Cette protéine a été découverte dans les années 90s et depuis sa fonction physiologique exacte n’est toujours pas connue. La frataxine joue un rôle important dans la biosynthèse des centres Fe-S dans l’homéostasie du fer et/ou dans la protection contre le stress oxydant. Dans cette thèse, nous nous intéressons aux interactions entre la protéine et d’autres molécules, comme certains métaux mitochondriaux ou protéines pour mieux comprendre la fonction de la frataxine dans la cellule. Lors de ce travail, la frataxine de levure (Yfh1) a été synthétisée par la technique de l’ADN recombinant, puis purifiée pour les études physico-chimiques. La flavohémoglobine (Yhb1)qui joue le rôle important dans la détoxification de NO (un agent du stress oxydatif et nitrosatif) a été aussi exprimée et purifiée selon le même principe. Ensuite, nous avons étudié la thermodynamique et la cinétique de la complexation de Yfh1 par les métaux mitochondriaux comme Fe, Cu, Mn, Zn, ainsi qu’avec les protéines impliquées dans le système antioxydant comme les superoxydes dismutases, CuZnSOD et MnSOD, et la flavohémoglobine. Ces résultats montrent tout d’abord que Yfh1 interagit avec tous les métaux mitochondriaux,néanmoins elle présente une meilleure affinité pour le cuivre et le manganèse. Par la suite, nous mettons en évidence le rôle remarquable de la frataxine dans le système antioxydant. Nous attribuons ainsi à la frataxine un rôle de protéine multifonctionnelle : « régulateur » dans le métabolisme des métaux.

The frataxin is a mitochondrial protein which is highly conserved during the evolution. The deficiency of frataxinin human induces a neurodegenerative disease: Friedreich’s ataxia. This protein was discovered in the nineties.However, its functions are always opened questions. It has been shown that frataxin participates in the assemblyof Fe-S cluster, as well as the iron homeostasis and cellular antioxidant system. The interactions between frataxinand others molecules, such as metals or proteins, are necessary for a better understanding of protein’s functions.In this work, we synthesized a yeast frataxin homologue (Yfh1) by DNA recombinant technique, and thenpurified it for cell free studies. Yeast flavohemoglobin (Yhb1), which is responsible for the detoxification of NO(an oxidative and nitrosative stress agent), was also isolated. We started by determining the thermodynamics andkinetics of the physiological interaction between Yfh1 and mitochondrial metals, such as Fe, Cu, Mn and Zn, aswell as the interaction with the gatekeepers in the anti-oxidative stress such as superoxide dismutases, CuZnSOD& MnSOD, and Yhb1. We underline here, in the first part the unspecific interaction of Yfh1 with mitochondrialmetals, and more especially the higher affinity of Yfh1 for copper and manganese than for iron. We also confirmthe remarkable…

Advisors/Committee Members: Ha-Duong, Nguyêt-Thanh (thesis director), El Hage Chahine, Jean-Michel (thesis director).

Subjects/Keywords: Homéostasie métallique; Métaux mitochondriaux; Relaxation chimique; Metal homeostasis; Mitochondrial metals; Relaxation chemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Han, T. (2016). Etudes de la fonction de la frataxine : relations avec l'homéostasie métallique et le stress oxydant. : Functional studies of Frataxin : relations with metal homeostasis and oxidatives stress. (Doctoral Dissertation). Sorbonne Paris Cité. Retrieved from http://www.theses.fr/2016USPCC288

Chicago Manual of Style (16^th Edition):

Han, Thi-Hong-Liên. “Etudes de la fonction de la frataxine : relations avec l'homéostasie métallique et le stress oxydant. : Functional studies of Frataxin : relations with metal homeostasis and oxidatives stress.” 2016. Doctoral Dissertation, Sorbonne Paris Cité. Accessed January 20, 2021. http://www.theses.fr/2016USPCC288.

MLA Handbook (7^th Edition):

Han, Thi-Hong-Liên. “Etudes de la fonction de la frataxine : relations avec l'homéostasie métallique et le stress oxydant. : Functional studies of Frataxin : relations with metal homeostasis and oxidatives stress.” 2016. Web. 20 Jan 2021.

Vancouver:

Han T. Etudes de la fonction de la frataxine : relations avec l'homéostasie métallique et le stress oxydant. : Functional studies of Frataxin : relations with metal homeostasis and oxidatives stress. [Internet] [Doctoral dissertation]. Sorbonne Paris Cité; 2016. [cited 2021 Jan 20]. Available from: http://www.theses.fr/2016USPCC288.

Council of Science Editors:

Han T. Etudes de la fonction de la frataxine : relations avec l'homéostasie métallique et le stress oxydant. : Functional studies of Frataxin : relations with metal homeostasis and oxidatives stress. [Doctoral Dissertation]. Sorbonne Paris Cité; 2016. Available from: http://www.theses.fr/2016USPCC288

IUPUI

3. LeVora, Jennifer K. THE ROLE OF SMF 1, SMF-2, SMF-3 IN METAL-INDUCED WHOLE ANIMAL VULNERABILITY AND DOPAMINE NEURON DEGENERATION IN CAENORHABDITIS ELEGANS.

Degree: 2012, IUPUI

URL: http://hdl.handle.net/1805/3177

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Indiana University-Purdue University Indianapolis (IUPUI)

The etiology of many neurodegenerative diseases is unknown, but a number of studies indicate that a combination of both genetic… (more)

Subjects/Keywords: dopamine; C. elegans; SMF; aluminum; copper; Parkinson's Disease; Dopamine; Neurotoxicology; Cell death; Parkinson's disease; Metal ions – Physiological effect; Nervous system – Degeneration – Molecular aspects; Oxidative stress; Metals – Toxicology; Homeostasis; Caenorhabditis elegans; Mitochondrial pathology; Copper – Physiological effect; Hepatolenticular degeneration; Alzheimer's disease

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

LeVora, J. K. (2012). THE ROLE OF SMF 1, SMF-2, SMF-3 IN METAL-INDUCED WHOLE ANIMAL VULNERABILITY AND DOPAMINE NEURON DEGENERATION IN CAENORHABDITIS ELEGANS. (Thesis). IUPUI. Retrieved from http://hdl.handle.net/1805/3177

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

LeVora, Jennifer K. “THE ROLE OF SMF 1, SMF-2, SMF-3 IN METAL-INDUCED WHOLE ANIMAL VULNERABILITY AND DOPAMINE NEURON DEGENERATION IN CAENORHABDITIS ELEGANS.” 2012. Thesis, IUPUI. Accessed January 20, 2021. http://hdl.handle.net/1805/3177.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

LeVora, Jennifer K. “THE ROLE OF SMF 1, SMF-2, SMF-3 IN METAL-INDUCED WHOLE ANIMAL VULNERABILITY AND DOPAMINE NEURON DEGENERATION IN CAENORHABDITIS ELEGANS.” 2012. Web. 20 Jan 2021.

Vancouver:

LeVora JK. THE ROLE OF SMF 1, SMF-2, SMF-3 IN METAL-INDUCED WHOLE ANIMAL VULNERABILITY AND DOPAMINE NEURON DEGENERATION IN CAENORHABDITIS ELEGANS. [Internet] [Thesis]. IUPUI; 2012. [cited 2021 Jan 20]. Available from: http://hdl.handle.net/1805/3177.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

LeVora JK. THE ROLE OF SMF 1, SMF-2, SMF-3 IN METAL-INDUCED WHOLE ANIMAL VULNERABILITY AND DOPAMINE NEURON DEGENERATION IN CAENORHABDITIS ELEGANS. [Thesis]. IUPUI; 2012. Available from: http://hdl.handle.net/1805/3177

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Miemczyk, Stefan. Towards the identification of environmental exposures and epigenetic marks related to the etiology of Autism.

Degree: Biology, 2017, Linköping University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-138946

► Autism is a complex disorder with possible genetic, epigenetic and environmental components. As the etiology remains uncertain and an increase in incidence is suspected,… (more)

Subjects/Keywords: autism spectrum disorders; cord blood; environmental factors; metals; method optimization; mitochondrial DNA; rheumatoid arthritis; Behavioral Sciences Biology; Etologi

…the exposure to heavy metals (Yassa 2014) or another single factor. Apart from one… …exposure of the fetus to heavy metals, chemicals, air pollution and pesticides, to name a few… …Hays et al. 1998) and might lead to a higher exposure to certain metals (Hutchinson… …of certain metals might be consumed during pregnancy. For example, a source of… …other metals. A study estimating the concentrations of lead and cadmium (Cd) in fish…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Miemczyk, S. (2017). Towards the identification of environmental exposures and epigenetic marks related to the etiology of Autism. (Thesis). Linköping University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-138946

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Miemczyk, Stefan. “Towards the identification of environmental exposures and epigenetic marks related to the etiology of Autism.” 2017. Thesis, Linköping University. Accessed January 20, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-138946.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Miemczyk, Stefan. “Towards the identification of environmental exposures and epigenetic marks related to the etiology of Autism.” 2017. Web. 20 Jan 2021.

Vancouver:

Miemczyk S. Towards the identification of environmental exposures and epigenetic marks related to the etiology of Autism. [Internet] [Thesis]. Linköping University; 2017. [cited 2021 Jan 20]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-138946.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Miemczyk S. Towards the identification of environmental exposures and epigenetic marks related to the etiology of Autism. [Thesis]. Linköping University; 2017. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-138946

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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