subject:(Midazolam)

Rhodes University

1. Lebete, Mosimotsana Leah. The influence of a methylated-β-Cyclodextrin on the solubility and photostability of midazolam in aqueous solution.

Degree: Faculty of Pharmacy, Pharmacy, 2001, Rhodes University

URL: http://hdl.handle.net/10962/d1005923

► Midazolam, used clinically as an anticonvulsant, anxiolytic, muscle relaxant and sedative is a photolabile imidazo-benzodiazepine which is marketed under the trade names Dormicum® and Hypnovel®… (more)

▼ Midazolam, used clinically as an anticonvulsant, anxiolytic, muscle relaxant and sedative is a photolabile imidazo-benzodiazepine which is marketed under the trade names Dormicum® and Hypnovel® as tablets and injectables. Because of an aqueous solubility of < 0.1 mg/ml above pH 4, the preparation of aqueous dosage formulations near physiological pH, requires a solubilizer. The aim of this study was thus to prepare a 10 mg/ml midazolam aqueous solution for topical application using randomly-methylated-pcyclodextrin (RAMEB), considered to be a suitable candidate as a solubilizer because of its absorption enhancing properties, and to investigate its effect on both the solubility and the photostability of midazolam. Solubility studies of midazolam (excess of 15 mg/ml) in the presence of 0, 5,10,20, 30% m/v of RAMEB at pH 5.0 and pH 5.8 (phosphate buffer) were undertaken and the results analyzed using a UV method validated for linearity, accuracy, precision and specificity. A stability-indicating HPLC method was developed and validated (precision and accuracy, linearity, range, limit of quantitation, specificity, robustness and ruggedness) for application to kinetic photostability studies and the identification of photodegradants by LC-MS. Forced degradation studies were carried out at concentrations of 0.5 mg/ml of midazolam instead of the target concentration of 10 mg/ml because of the acceleratory effect of the decreased concentration on the rate of photodegradation. The solutions of midazolam with and without RAMEB were irradiated at 550 W/m² for 12 hrs in order to degrade the drug to ± 10% of the original concentration. The UV method proved to be valid in terms of linearity with a correlation coefficient of 0.9998, precise and accurate, and specific for the determination of midazolam in the presence of RAMEB. The results of the phase solubility studies indicated that desired solubility of 10 mg/ml was achieved with 30% m/v RAMEB at pH 5.0. RAMEB slightly decreased the photostability of midazolam, the rate constants being 0.137 and 0.154 hr⁻¹ in the absence and presence of RAMEB, respectively. LC-MS analysis revealed that one of the major photoproducts in the presence and absence of RAMEB was N-desalkylflurazepam, a starting material in the synthesis of midazolam. RAMEB inhibited formation of some photoproducts and introduced two new photoproducts, a dimer and an addition product. The difference in the nature of these photoproducts formed may be attributed to the ability of RAMEB to provide conformational control and to stabilize free radicals. Although RAMEB improved the solubility of midazolam to the target concentration, photostability is decreased with the presence of different photoproducts. These studies have however provided information on the overall photostability of midazolam, the identity of its photodegradants and the photodegradation pathway in the presence and absence of RAMEB, and may be used for further method development and validation for the analysis of aqueous dosage forms containing RAMEB as a…

Subjects/Keywords: Midazolam – Solubility

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APA (6^th Edition):

Lebete, M. L. (2001). The influence of a methylated-β-Cyclodextrin on the solubility and photostability of midazolam in aqueous solution. (Thesis). Rhodes University. Retrieved from http://hdl.handle.net/10962/d1005923

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lebete, Mosimotsana Leah. “The influence of a methylated-β-Cyclodextrin on the solubility and photostability of midazolam in aqueous solution.” 2001. Thesis, Rhodes University. Accessed March 06, 2021. http://hdl.handle.net/10962/d1005923.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lebete, Mosimotsana Leah. “The influence of a methylated-β-Cyclodextrin on the solubility and photostability of midazolam in aqueous solution.” 2001. Web. 06 Mar 2021.

Vancouver:

Lebete ML. The influence of a methylated-β-Cyclodextrin on the solubility and photostability of midazolam in aqueous solution. [Internet] [Thesis]. Rhodes University; 2001. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/10962/d1005923.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lebete ML. The influence of a methylated-β-Cyclodextrin on the solubility and photostability of midazolam in aqueous solution. [Thesis]. Rhodes University; 2001. Available from: http://hdl.handle.net/10962/d1005923

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Sydney

2. Olsson, Annabelle. Investigation into developing reliable immobilisation protocol for use under varying environmental temperatures in estuarine and Australian freshwater crocodiles .

Degree: 2013, University of Sydney

URL: http://hdl.handle.net/2123/10446

► The objective of this research was to determine a set of commonly available chemical restraint options which produced safe, reliable and repeatable immobilisation for estuarine… (more)

Subjects/Keywords: Crocodile; Immobilisation; Medetomidine; Alfaxalone; Midazolam

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APA (6^th Edition):

Olsson, A. (2013). Investigation into developing reliable immobilisation protocol for use under varying environmental temperatures in estuarine and Australian freshwater crocodiles . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/10446

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Olsson, Annabelle. “Investigation into developing reliable immobilisation protocol for use under varying environmental temperatures in estuarine and Australian freshwater crocodiles .” 2013. Thesis, University of Sydney. Accessed March 06, 2021. http://hdl.handle.net/2123/10446.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Olsson, Annabelle. “Investigation into developing reliable immobilisation protocol for use under varying environmental temperatures in estuarine and Australian freshwater crocodiles .” 2013. Web. 06 Mar 2021.

Vancouver:

Olsson A. Investigation into developing reliable immobilisation protocol for use under varying environmental temperatures in estuarine and Australian freshwater crocodiles . [Internet] [Thesis]. University of Sydney; 2013. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/2123/10446.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Olsson A. Investigation into developing reliable immobilisation protocol for use under varying environmental temperatures in estuarine and Australian freshwater crocodiles . [Thesis]. University of Sydney; 2013. Available from: http://hdl.handle.net/2123/10446

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Castro, Diogo Gorayeb de. Efeitos do midazolam, associado ao propofol, na indução da anestesia em gatas submetidas a ovariossalpingo-histerectomia.

Degree: Mestrado, Clínica Cirúrgica Veterinária, 2010, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/10/10137/tde-27012012-093140/ ;

►

O propofol é o fármaco mais freqüentemente empregado na indução da anestesia de pequenos animais apesar de seu efeito depressor cardiovascular e respiratório. Sabe-se que… (more)

▼

O propofol é o fármaco mais freqüentemente empregado na indução da anestesia de pequenos animais apesar de seu efeito depressor cardiovascular e respiratório. Sabe-se que a associação com outros fármacos pode determinar a redução de suas doses e essa possibilidade é pouco conhecida nos felinos. No presente estudo, foram avaliados os efeitos do emprego do midazolam associado ao propofol na indução da anestesia em gatas submetidas a ovariossalpingo-histerectomia. Foram utilizadas 30 gatas, jovens adultas, submetidas a ovariossalpingo-histerectomia. Após serem pré-tratadas com acepromazina e morfina, foram distribuídas em três grupos: o grupo GP recebeu indução somente com propofol; o grupo GMP recebeu midazolam imediatamente antes da indução com propofol; e o grupo GPM recebeu uma subdose de propofol, seguido por midazolam e novamente propofol até ser possível a intubação. Foi avaliada a redução da dose do propofol quando em associação com midazolam; a qualidade de intubação endotraqueal e grau de relaxamento muscular; a qualidade de indução da anestesia após a administração de propofol ou propofol em associação com midazolam, analisando qual a melhor seqüência de administração e a qualidade e o tempo de recuperação nas gatas submetidas à indução da anestesia com propofol ou propofol-midazolam. Foram também observados as freqüências cardíaca e respiratória, pressão arterial, oximetria, capnometria e hemogasometria. A partir dos resultados obtidos verificou-se que a dose de propofol para indução da anestesia em gatas é reduzida em 34% e 23% quando precedido ou antecedido pelo midazolam, respectivamente; a associação com midazolam não intensificou o relaxamento muscular promovido pelo propofol, não interferindo assim na qualidade de intubação endotraqueal das gatas; o uso prévio de midazolam em relação ao propofol na indução da anestesia não determinou agitação, tampouco excitação nas gatas; ambas as seqüências de administração da associação propofol-midazolam são factíveis, porém a seqüência propofol-midazolam se mostrou superior devido a menor dose empregada de propofol; do ponto de vista clínico, a associação com midazolam determinou prolongamento do tempo de recuperação das gatas, mas não determinou efeitos adversos no momento de despertar.

Propofol is the most frequent drug used for induction of anesthesia in small animals. Its cardiovascular and respiratory depressor effects are well known. The association with other drugs may determine a reduction of its dose, and this possibility is not well known in cats. The present study evaluated the effects of midazolam associated to propofol during induction of anesthesia in cats submitted to ovariohysterectomy. Thirty cats were enrolled in this study. After premedicated with acepromazine and morphine, they were distributed in three groups: GP group that received only propofol for induction; GMP group that received midazolam immediately before propofol induction; and GPM group that received a sub dose of propofol, followed by midazolam and propofol until intubation was…

Advisors/Committee Members: Cortopassi, Silvia Renata Gaido.

Subjects/Keywords: Anestesia balanceada; Balanced anesthesia; Cats; Gatos; Midazolam; Midazolam; Propofol; Propofol

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Castro, D. G. d. (2010). Efeitos do midazolam, associado ao propofol, na indução da anestesia em gatas submetidas a ovariossalpingo-histerectomia. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/10/10137/tde-27012012-093140/ ;

Chicago Manual of Style (16^th Edition):

Castro, Diogo Gorayeb de. “Efeitos do midazolam, associado ao propofol, na indução da anestesia em gatas submetidas a ovariossalpingo-histerectomia.” 2010. Masters Thesis, University of São Paulo. Accessed March 06, 2021. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-27012012-093140/ ;.

MLA Handbook (7^th Edition):

Castro, Diogo Gorayeb de. “Efeitos do midazolam, associado ao propofol, na indução da anestesia em gatas submetidas a ovariossalpingo-histerectomia.” 2010. Web. 06 Mar 2021.

Vancouver:

Castro DGd. Efeitos do midazolam, associado ao propofol, na indução da anestesia em gatas submetidas a ovariossalpingo-histerectomia. [Internet] [Masters thesis]. University of São Paulo; 2010. [cited 2021 Mar 06]. Available from: http://www.teses.usp.br/teses/disponiveis/10/10137/tde-27012012-093140/ ;.

Council of Science Editors:

Castro DGd. Efeitos do midazolam, associado ao propofol, na indução da anestesia em gatas submetidas a ovariossalpingo-histerectomia. [Masters Thesis]. University of São Paulo; 2010. Available from: http://www.teses.usp.br/teses/disponiveis/10/10137/tde-27012012-093140/ ;

University of Tasmania

4. Jones, RDM. Midazolam as an anaesthetic agent in children.

Degree: 1995, University of Tasmania

URL: https://eprints.utas.edu.au/20375/7/whole_JonesRobertDouglasMorrison1995.pdf

► A relatively high dose of midazolam has to be administered orally to achieve the favourable effects of premedication in children and this could be associated… (more)

▼ A relatively high dose of midazolam has to be administered orally to achieve the favourable effects of premedication in children and this could be associated with arterial oxygen desaturation. Pethidine has been commonly administered as a premedicant to children for many years, however its association with oximetric desaturation has not previously been investigated. In this thesis the incidence, duration and severity of oximetric desaturation episodes was determined following premedication in children with midazolam and pethidine. To facilitate this research, SatmasterTM, a computer programme which permits storage, retrieval, signal evaluation and data compilation, was developedin conjunction with the software authors and subjected to artefact template analysis to reduce the inclusion of spurious oximetric data in the determination of the incidence of desaturation. It was found that neither pethidine nor midazolam premedication increased the incidence of episodic desaturation when compared to that occurring during normal sleep. If analgesia is not a premedication requirement, oral midazolam confers the advantage over pethidine of avoiding the pain of an intramuscular injection, without compromising oxygen saturation. The availability of flumazenil permits specific reversal of the unconsciousness and reflex depression associated with the hypnotic effect of midazolam administration. The combined pharmacokinetics and pharmacodynamics of midazolam and flumazenil in children have not previously been reported. Midazolam pharmacokinetics were shown to compare favourably with those of propofol in a similar patient population and it was found that midazolam antagonism with flumazenil produced similar clinical awakening rates to those achieved after propofol induction. Blood pressure changes on induction were measured using a standard intermittent noninvasive technique and these were compared with continuous pressure measurements using a Finapres, modified for paediatric use and computerised data acquisition. Propofol induction was associated with hypotension of a significantly greater degree and duration compared to midazolam and thiopentone. Postoperative recovery after anaesthesia is particularly important for ambulatory surgery. The effect of midazolam on psychomotor performance, residual sedation and mood was shown to be related to plasma concentration. These indices were also used to assess recovery after anaesthetic induction with either midazolam, thiopentone or propofol. A post-box toy completion ratio (PBTR) was developed for assessment of psychomotor performance in children and compared with a standard component of the Wechsler intelligence scale (WISC-R). The PBTR was found to be as sensitive as the WISC-R in this assessment, but also has the advantage of ease of administration. The quality and rate of recovery following unantagonised midazolam induction in the immediate postoperative period is inferior to propofol and thiopentone but within one hour of awakening there is no…

Subjects/Keywords: Midazolam; Pediatric anesthesia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jones, R. (1995). Midazolam as an anaesthetic agent in children. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/20375/7/whole_JonesRobertDouglasMorrison1995.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jones, RDM. “Midazolam as an anaesthetic agent in children.” 1995. Thesis, University of Tasmania. Accessed March 06, 2021. https://eprints.utas.edu.au/20375/7/whole_JonesRobertDouglasMorrison1995.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jones, RDM. “Midazolam as an anaesthetic agent in children.” 1995. Web. 06 Mar 2021.

Vancouver:

Jones R. Midazolam as an anaesthetic agent in children. [Internet] [Thesis]. University of Tasmania; 1995. [cited 2021 Mar 06]. Available from: https://eprints.utas.edu.au/20375/7/whole_JonesRobertDouglasMorrison1995.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jones R. Midazolam as an anaesthetic agent in children. [Thesis]. University of Tasmania; 1995. Available from: https://eprints.utas.edu.au/20375/7/whole_JonesRobertDouglasMorrison1995.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Estado do Rio de Janeiro

5. Guilherme Loures de Araújo Penna. Efeito da sedação na microcirculação de pacientes em choque séptico.

Degree: PhD, 2013, Universidade do Estado do Rio de Janeiro

URL: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=9325 ;

► Ao longo dos últimos anos, apesar de todo desenvolvimento e pesquisa, a mortalidade na sepse permanece elevada. Na área de microcirculação foram realizados estudos em… (more)

▼ Ao longo dos últimos anos, apesar de todo desenvolvimento e pesquisa, a mortalidade na sepse permanece elevada. Na área de microcirculação foram realizados estudos em modelos experimentais de sepse ao longo das últimas duas décadas, quando se observou, através de técnicas invasivas, alterações como redução expressiva da densidade capilar funcional. A técnica denominada sidestream dark field (SDF) imaging, recentemente desenvolvida, permite a avaliação da microcirculação de forma transcutânea. A utilização desta técnica permitiu evidenciar a redução da densidade capilar funcional em pacientes com sepse grave quando comparado a um indivíduo saudável. Posteriormente, foi demonstrado que alterações persistentes na microcirculação de pacientes sépticos, mesmo com sinais vitais estabilizados, estão associadas com pior prognóstico.Evidentemente, os pacientes com sepse grave ou choque séptico sofrem uma grande quantidade de intervenções terapêuticas, aonde muitas delas alteram a microcirculação. Estudos analisando a microcirculação em pacientes em uso de nitroglicerina, corticóide, recebendo hemotransfusão ou ainda infusão de noradrenalina foram publicados recentemente.Entretanto, até o presente momento, não existem publicações que descrevam a influência dos sedativos na microcirculação de pacientes com choque séptico. As drogas mais comumente utilizadas para sedação de pacientes em ventilação mecânica são o sedativo midazolam e o anestésico propofol. Os objetivos do estudo foram: avaliar o efeito dos principais agentes sedativos utilizados na prática clínica na microcirculação de pacientes com choque séptico utilizando a técnica de sidestream dark field imaging, comparar os efeitos na microcirculação do midazolam com o propofol em pacientes com choque séptico e verificar se existe relação das alterações microcirculatórias provocadas pelos sedativos com as variações de diferentes parâmetros hemodinâmicos, gasométricos ou metabólicos como pressão arterial, índice cardíaco, lactato e saturação venosa central de oxigênio. Foram estudados (estudo prospectivo) 16 pacientes internados no Centro de Terapia Intensiva da Casa de Saúde São José. Os pacientes internados com diagnóstico de choque séptico e que possuíam indicação clínica de ventilação mecânica e de suspensão diária da sedação foram submetidos ao estudo da microcirculação na mucosa sublingual utilizando a técnica de sidestream dark field imaging. Estes pacientes foram sedados conforme orientação do protocolo já existente de sedação, inicialmente com propofol e posteriormente com midazolam. Os principais resultados observados foram:a macrohemodinâmica não diferiu nos 2 momentos do exame, o BIS (bispectral índex of sedation) se manteve na faixa recomendada nos 2 momentos do exame, tendo aumentado quando o paciente acordava, conforme esperado, e a proporção de vasos pequenos perfundidos e o índice de fluxo da microcirculação foram significativamente menores, enquanto o índice de heterogeneidade foi significativamente maior quando os pacientes estavam recebendo infusão de… Advisors/Committee Members: Nivaldo Ribeiro Villela, Eliete Bouskela, Eduardo Vera Tibiriçá, Mário Fritsch Toros Neves, Edmar Jose Alves dos Santos, Fernando Augusto Bozza.

Subjects/Keywords: Microcirculação; Choque séptico; Sedação; Propofol; Midazolam; Microcirculation; Septic shock; Sedation; Propofol; Midazolam; CLINICA MEDICA; Choque séptico - Teses; Sedativos - Teses; Microcirculação - Teses; Capilares - Teses; Propofol - Uso terapêutico; Midazolam - Uso terapêutico

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Penna, G. L. d. A. (2013). Efeito da sedação na microcirculação de pacientes em choque séptico. (Doctoral Dissertation). Universidade do Estado do Rio de Janeiro. Retrieved from http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=9325 ;

Chicago Manual of Style (16^th Edition):

Penna, Guilherme Loures de Araújo. “Efeito da sedação na microcirculação de pacientes em choque séptico.” 2013. Doctoral Dissertation, Universidade do Estado do Rio de Janeiro. Accessed March 06, 2021. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=9325 ;.

MLA Handbook (7^th Edition):

Penna, Guilherme Loures de Araújo. “Efeito da sedação na microcirculação de pacientes em choque séptico.” 2013. Web. 06 Mar 2021.

Vancouver:

Penna GLdA. Efeito da sedação na microcirculação de pacientes em choque séptico. [Internet] [Doctoral dissertation]. Universidade do Estado do Rio de Janeiro; 2013. [cited 2021 Mar 06]. Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=9325 ;.

Council of Science Editors:

Penna GLdA. Efeito da sedação na microcirculação de pacientes em choque séptico. [Doctoral Dissertation]. Universidade do Estado do Rio de Janeiro; 2013. Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=9325 ;

6. Braun, Ivan Mario. Potencial de abuso do midazolam intranasal em usuários de cocaína aspirada e voluntários normais.

Degree: PhD, Psiquiatria, 2012, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5142/tde-28112012-124456/ ;

► INTRODUÇÃO: O midazolam é uma imidazobenzodiazepina usada para induzir o sono, produzir sedação antes de procedimentos dolorosos e no tratamento do estado de mal epiléptico.… (more)

▼ INTRODUÇÃO: O midazolam é uma imidazobenzodiazepina usada para induzir o sono, produzir sedação antes de procedimentos dolorosos e no tratamento do estado de mal epiléptico. Seu uso pela via intranasal proporciona um rápido início de ação e esta via, em muitos casos, pode substituir as vias endovenosa e intramuscular, mais invasivas. Assim, o midazolam intranasal tem sido sugerido no tratamento extra-hospitalar de crises epilépticas e ataques de pânico. Por outro lado, os benzodiazepínicos possuem um potencial para serem abusados, principalmente em usuários de outras drogas. OBJETIVO: o presente estudo objetivou verificar o potencial de abuso do midazolam intranasal numa população experiente no uso intranasal de substâncias - abusadores de cocaína aspirada. MÉTODOS: Foram estudados 31 voluntários abusadores ou dependentes de cocaína e 34 controles saudáveis, subdivididos em quatro grupos: Abusadores de Cocaína (N = 16) e Voluntários Saudáveis (N= 17) que receberam midazolam (0,5 mg de hidrocloreto de midazolam em cada narina), e Abusadores de Cocaína (N = 15) e Voluntários Saudáveis (N = 17) que receberam o mesmo volume de um placebo ativo. As variáveis de resposta foram a Apreciação da Substância (AS) e a Vontade de Repetir o Uso da Substância (VR), avaliadas através de escalas analógicas visuais. RESULTADOS: A análise de perfis para medidas repetidas das variáveis de resposta mostrou um efeito significante da variável Tempo sobre AS (F[5;57] =3,947, p=0,004) e VR (F[5;57] =3,311, p=0,011). A variável Grupo (Abusadores de Cocaína x Voluntários Saudáveis) também teve um impacto sobre as variáveis de resposta AS e VR, sendo que os Abusadores de Cocaína tiveram pontuações mais altas tanto em AS (F[5;57] = 4,946, p = 0,030) quanto em VR (F[5;57] =5,229, p=0,026). Numa análise de regressão linear para investigar os efeitos do humor - medidos através de uma Escala Visual Analógica do Humor (VAMS) - sobre as variáveis de resposta AS e VR, os Abusadores de Cocaína apresentaram escores maiores que os Voluntários saudáveis tanto para AS (t = 3,37; p = 0,001) quanto para VR (t = 5,607; p = 0,011). Observou-se, também, um efeito dos fatores VAMS 16 (MAIS DEPRIMIDO MAIS EUFÓRICO; t = 4,28; p < 0,001) e VAMS 12 (MAIS EXCITADO MAIS RELAXADO; t = 2,66; p = 0,010), sobre a variável de resposta AS (R2 = 0,32): níveis maiores de euforia e relaxamento predisseram uma maior Apreciação da Substância instilada. O fator VAMS 16 (MAIS DEPRIMIDO MAIS EUFÓRICO) teve um efeito também sobre a variável de resposta VR (t = 3,65, p < 0,001; R2 =0,24): maior euforia predisse maior vontade de repetir o uso da substância. Finalmente, uma análise de regressão linear utilizando-se AS como variável explicativa e VR como variável de resposta resultou que quanto maior a apreciação positiva da substância, maior era a vontade de repetir seu uso (F = 108, 517; p < 0,001; R2 = 0,65). CONCLUSÕES: Corroborando estudos anteriores, observou-se que sensações como relaxamento e euforia correlacionam-se com o potencial de abuso de uma substância e uma maior… Advisors/Committee Members: Bernik, Marcio Antonini.

Subjects/Keywords: Administração intranasal de medicamentos; Administration intranasal; Benzodiazepinas/farmacologia; Benzodiazepinas/uso terapêutico; Benzodiazepines/ therapeutic use; Benzodiazepines/pharmacology; Midazolam; Midazolam

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Braun, I. M. (2012). Potencial de abuso do midazolam intranasal em usuários de cocaína aspirada e voluntários normais. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5142/tde-28112012-124456/ ;

Chicago Manual of Style (16^th Edition):

Braun, Ivan Mario. “Potencial de abuso do midazolam intranasal em usuários de cocaína aspirada e voluntários normais.” 2012. Doctoral Dissertation, University of São Paulo. Accessed March 06, 2021. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-28112012-124456/ ;.

MLA Handbook (7^th Edition):

Braun, Ivan Mario. “Potencial de abuso do midazolam intranasal em usuários de cocaína aspirada e voluntários normais.” 2012. Web. 06 Mar 2021.

Vancouver:

Braun IM. Potencial de abuso do midazolam intranasal em usuários de cocaína aspirada e voluntários normais. [Internet] [Doctoral dissertation]. University of São Paulo; 2012. [cited 2021 Mar 06]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5142/tde-28112012-124456/ ;.

Council of Science Editors:

Braun IM. Potencial de abuso do midazolam intranasal em usuários de cocaína aspirada e voluntários normais. [Doctoral Dissertation]. University of São Paulo; 2012. Available from: http://www.teses.usp.br/teses/disponiveis/5/5142/tde-28112012-124456/ ;

7. Mekitarian Filho, Eduardo. Utilização do midazolam intranasal como sedativo para tomografia em crianças.

Degree: PhD, Pediatria, 2013, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5141/tde-20052013-154238/ ;

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Objetivos: Avaliar a segurança e a eficácia do midazolam intranasal (MIN) para sedação para tomografia em crianças, bem como a qualidade dos estudos radiológicos obtidos… (more)

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Objetivos: Avaliar a segurança e a eficácia do midazolam intranasal (MIN) para sedação para tomografia em crianças, bem como a qualidade dos estudos radiológicos obtidos com esta técnica. Material e métodos: Entre dezembro de 2011 e julho de 2012, este estudo prospectivo avaliou o MIN como sedativo para crianças submetidas à tomografia sem acesso venoso. Após aprovação do Comitê de Ética em Pesquisa e consentimento dos responsáveis, 0,4 mg/kg de MIN foi administrado, sendo feita dose adicional de 0,1 mg/kg se o nível de sedação avaliado pela Escala de Sedação de Ramsay não fosse atingida após 15 minutos da primeira dose. Os desfechos relacionados à sedação incluíram tempo para sedação e para atingir os critérios de alta; parâmetros fisiológicos como oximetria de pulso e frequência cardíaca foram registrados a cada cinco minutos até a alta. A qualidade dos exames tomográficos foi avaliada quanto à presença de artefatos de imagem e movimento. Resultados: 60 eventos de sedação foram realizados em 58 pacientes. A idade média foi de 15,5 meses, sendo 90,9% dos exames tomográficos de crânio. O tempo médio para sedação foi de 15,2 minutos (5-40) e o tempo médio para atingir os critérios de alta foi de 74,7 minutos. Eventos adversos foram observados em 5 crianças (8,4%), incluindo reação paradoxal (3), tempo de recuperação prolongado (1) e vômitos (1). Apenas 4 pacientes (6,7%) não foram adequadamente sedados com MIN. Imagens consideradas excelentes, sem artefatos, foram obtidas em 56 (93,3%) sedações. Não houve eventos como bradicardia, hipoxemia ou hipotensão. Conclusões: O midazolam intranasal, administrado via atomizador nasal, é um método simples e não-invasivo para sedação segura, eficaz e previsível para crianças na obtenção de estudos tomográficos de qualidade

Objective: To evaluate the safety, efficacy and image quality of sedation with aerosolized intranasal midazolam for pediatric CT studies. Materials and Methods: Between December 2011 to May 2012, this prospective study evaluated aerosolized intranasal (AIN) midazolam as a sedative for CT of children without intravenous access. After IRB approval and parental consent, 0,4 mg/kg of AIN midazolam was administered, and repeated with 0.1 mg/kg if adequate sedation evaluated by Ramsay Sedation Scale not achieved in 15 minutes after the first dose. Sedation outcome variables which included time to achieve sedation, to meet discharge criteria and physiological vital signs of pulse oximetry and heart rate, were recorded every five minutes until discharge. The quality of CT images was reviewed and graded for presence of motion and imaging artifacts, Results: 60 sedation encounters were performed in 58 children. Mean age was 15.5 months, and 90.9% of CT scans were brain scans. Mean time to sedation was 15.2 minutes (range 5-40) and mean time to achieve discharge criteria was 74.7 minutes. Adverse events were recorded in 5 children (8.4%) that underwent sedation - paradoxical reaction (3), prolonged recovery time (1) and vomiting (1). Only 4 patients (6.7%) failed to…

Advisors/Committee Members: Carvalho, Werther Brunow de.

Subjects/Keywords: Administração intranasal; Computerized tomography; Conscious sedation/ adverse effects; Intranasal administration; Midazolam; Midazolam; Pediatria; Pediatrics; Sedação consciente/ efeitos adversos; Tomografia computadorizada

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mekitarian Filho, E. (2013). Utilização do midazolam intranasal como sedativo para tomografia em crianças. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5141/tde-20052013-154238/ ;

Chicago Manual of Style (16^th Edition):

Mekitarian Filho, Eduardo. “Utilização do midazolam intranasal como sedativo para tomografia em crianças.” 2013. Doctoral Dissertation, University of São Paulo. Accessed March 06, 2021. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-20052013-154238/ ;.

MLA Handbook (7^th Edition):

Mekitarian Filho, Eduardo. “Utilização do midazolam intranasal como sedativo para tomografia em crianças.” 2013. Web. 06 Mar 2021.

Vancouver:

Mekitarian Filho E. Utilização do midazolam intranasal como sedativo para tomografia em crianças. [Internet] [Doctoral dissertation]. University of São Paulo; 2013. [cited 2021 Mar 06]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5141/tde-20052013-154238/ ;.

Council of Science Editors:

Mekitarian Filho E. Utilização do midazolam intranasal como sedativo para tomografia em crianças. [Doctoral Dissertation]. University of São Paulo; 2013. Available from: http://www.teses.usp.br/teses/disponiveis/5/5141/tde-20052013-154238/ ;

8. Jacomelli, Marcia. Estudo nasofaringoscópico da síndrome da apnéia-hipopnéia obstrutiva do sono: comparação entre a manobra de Muller e o sono induzido.

Degree: PhD, Pneumologia, 2007, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5150/tde-03052007-105936/ ;

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Introdução: A síndrome da apnéia-hipopnéia obstrutiva do sono (SAHOS) é caracterizada por episódios recorrentes de colapso parcial ou completo da faringe responsáveis por roncos e… (more)

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Introdução: A síndrome da apnéia-hipopnéia obstrutiva do sono (SAHOS) é caracterizada por episódios recorrentes de colapso parcial ou completo da faringe responsáveis por roncos e eventos de apnéia ou hipopnéia, com queda da saturação de oxigênio (SaO2) e despertares freqüentes durante a noite de sono. A nasofaringoscopia com a manobra de Muller (MM) é utilizada rotineiramente na avaliação pré-operatória destes pacientes para diagnóstico do sítio da obstrução retropalatal (RP) e retrolingual (RL) e planejamento terapêutico, porém existem controvérsias a respeito de seus benefícios. Os estudos que mostram sensibilidade do sono induzido (SI) neste sentido utilizaram métodos subjetivos de avaliação e doses não controladas do indutor do sono. Objetivos: O principal objetivo do estudo foi comparar o colapso da faringe observado pelos dois métodos diagnósticos, a MM e o SI, através da análise quantitativa da obstrução documentada pela vídeo-nasofaringoscopia, e estudar as correlações deste colapso com o índice de apnéia-hipopnéia (IAH) e a SaO2 mínina noturna. Métodos: Foram estudados prospectivamente 24 pacientes com SAHOS (IAH > 10) e 15 controles saudáveis (IAH < 5) por meio da vídeo-nasofaringoscopia com MM e SI. O video-broncoscópio Olympus com canal de trabalho de 2,0 mm foi utilizado durante o procedimento. Todos os pacientes foram avaliados em decúbito dorsal horizontal e com a cabeça vi em posição neutra. Durante a MM, a pressão negativa intrafaríngea foi controlada por meio de um manovacuômetro conectado ao canal de trabalho do video-broncoscópio. Baixa dose e infusão lenta de midazolam foram utilizadas na indução do sono, e o controle da dose foi realizado por meio da polissonografia (PSG) em tempo real ao exame endoscópico. As imagens das variações de áreas e diâmetros, laterolateral e ântero-posterior obtidas, durante a MM e o SI, foram capturadas e posteriormente analisadas no programa de computador OSIRIS (Osiris Medical Imaging Software - University Hospital of Geneva). Resultados: O colapso faríngeo foi mais significativo em indivíduos com SAHOS durante o SI. Na região RP o colapso das paredes da faringe à MM foi semelhante àquele do SI. Na região RL o colapso à MM foi significativamente inferior ao observado no SI. Diferente do que ocorreu na MM, o colapso RL durante o SI apresentou boa correlação com o IAH e a SaO2 mínima noturna. A dose total de midazolam necessária à indução do sono foi significativamente menor no grupo SAHOS. Conclusão: A vídeo-nasofaringoscopia com SI e análise quantitativa do colapso se mostrou um método simples, superior à MM para documentar a obstrução funcional da faringe, apresentando boa correlação com os índices da PSG noturna devendo ser realizada na prática clínica.

Introduction: Obstructive sleep apnea syndrome (OSAHS) is characterized by partial or total collapse of the retropalatal (RP) or retroglosal (RG) pharynx during sleep. It is responsible for episodes of apnea-hypopnea, snore and sleep fragmentation. Nasopharyngoscopy with Muller Maneuver (MM) has been used to…

Advisors/Committee Members: Pedreira Junior, Wilson Leite.

Subjects/Keywords: Apnéia do sono tipo obstrutiva; Comparative study; Endoscopia; Endoscopy; Estudo comparativo; Faringe; Midazolam; Midazolam; Pharynx; Sleep apnea obstructive

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jacomelli, M. (2007). Estudo nasofaringoscópico da síndrome da apnéia-hipopnéia obstrutiva do sono: comparação entre a manobra de Muller e o sono induzido. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5150/tde-03052007-105936/ ;

Chicago Manual of Style (16^th Edition):

Jacomelli, Marcia. “Estudo nasofaringoscópico da síndrome da apnéia-hipopnéia obstrutiva do sono: comparação entre a manobra de Muller e o sono induzido.” 2007. Doctoral Dissertation, University of São Paulo. Accessed March 06, 2021. http://www.teses.usp.br/teses/disponiveis/5/5150/tde-03052007-105936/ ;.

MLA Handbook (7^th Edition):

Jacomelli, Marcia. “Estudo nasofaringoscópico da síndrome da apnéia-hipopnéia obstrutiva do sono: comparação entre a manobra de Muller e o sono induzido.” 2007. Web. 06 Mar 2021.

Vancouver:

Jacomelli M. Estudo nasofaringoscópico da síndrome da apnéia-hipopnéia obstrutiva do sono: comparação entre a manobra de Muller e o sono induzido. [Internet] [Doctoral dissertation]. University of São Paulo; 2007. [cited 2021 Mar 06]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5150/tde-03052007-105936/ ;.

Council of Science Editors:

Jacomelli M. Estudo nasofaringoscópico da síndrome da apnéia-hipopnéia obstrutiva do sono: comparação entre a manobra de Muller e o sono induzido. [Doctoral Dissertation]. University of São Paulo; 2007. Available from: http://www.teses.usp.br/teses/disponiveis/5/5150/tde-03052007-105936/ ;

9. Barbara Caetano Pereira. Avaliação da memória emocional em camundongos : efeito da injeção de midazolam na substância cinzenta periaquedutal.

Degree: 2012, Universidade Federal de São Carlos

URL: http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=6220

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Varios estudos tem demonstrado que os benzodiazepinicos (BDZ), administrados na substancia cinzenta periaquedutal (SCP), podem produzir efeito ansiolitico em diferentes modelos animais de ansiedade e… (more)

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Varios estudos tem demonstrado que os benzodiazepinicos (BDZ), administrados na substancia cinzenta periaquedutal (SCP), podem produzir efeito ansiolitico em diferentes modelos animais de ansiedade e tambem prejudicar a aprendizagem e a memoria em roedores. Apesar do ja conhecido papel da SCP em modular comportamentos defensivos em modelos animais, pouco se sabe sobre o seu papel na modulacao da memoria emocional. Neste sentido, o objetivo desde estudo foi investigar os efeitos do midazolam, intra-SCP, sobre a aquisicao, consolidacao e evocacao da memoria aversiva. Para isto, utilizamos camundongos machos da linhagem Suico-Albino, pesando entre 25-30g (n=7-11/grupo). Os animais apos cirurgia estereotaxica com implantacao de canula na SCP, no dia do teste foram distribuidos em tres Experimentos para posteriormente serem expostos ao teste de step-down (SD), a saber: Experimento 1, injecao intra-SCP com salina e midazolam (MDZ) nas doses de 3,0 e 30 nmol/0,1μl, na condicao de pre-treino ao SD para avaliar a aquisicao da memoria aversiva; Experimento 2, conforme Experimento 1, exceto pela condicao de injecao pre-teste ao SD para avaliar a evocacao da memoria aversiva; Experimento 3, conforme Experimento 1, exceto pela condicao de injecao pos-treino ao SD para avaliar a consolidacao da memoria aversiva. Os animais foram treinados na tarefa de esquiva inibitoria que consistiu em distribuir os animais em dois grupos: S/Ch - sem exposicao ao choque; C/Ch com exposicao ao choque (0,5mA) por 10s, para registro da latencia de descida (L1). Vinte e quatro horas apos, cada animal foi exposto novamente ao SD para registro da latencia (L2), mas sem o choque. Os resultados foram avaliados pela analise de variancia (ANOVA) de tres fatores (Fator 1: condicao; Fator 2: pre-tratamento; Fator 3: tratamento), durante L1 e L2. Os resultados mostraram que ocorreu aumento de L2, apos a exposicao de camundongos ao SD sem apresentacao de choque, confirmando que o estimulo aversivo (choque) foi forte o suficiente para promover facilitacao da memoria aversiva. As duas doses (3,0 e 30 nmol) de MDZ intra-SCP diminuiram a avaliacao de risco dos camundongos, caracterizada pela rapida descida da plataforma em L1. Este resultado sugere que este agonista GABABenzodiazepinico, prejudicou a aquisicao, evocacao e consolidacao da memoria aversiva em camundongos. Em conjunto, esses resultados sugerem que os receptores GABAA localizados na SCP participam da modulacao das respostas relacionadas a memoria aversiva induzida pelo choque.

Several studies have shown that benzodiazepines (BDZ) in periaqueductal gray (PAG) can produce anxiolytic-like effects in different animal models of anxiety. In addition, BDZ drugs also impair learning and memory performance in rodents. Despite the known role of PAG in modulated defensive behaviors in animal models, little is known about its role in modulated of emotional memory. In this sense, the objective of this study was to investigate the effects of midazolam, injected into the PAG, on the acquisition,…

Advisors/Committee Members: Azair Liane Matos do Canto de Souza.

Subjects/Keywords: Substância cinzenta periaquedutal; Ansiedade; Esquiva inibitória; Camundongos; Midazolam; PSICOLOGIA; Memory; Anxiety; Periaqueductal gray matter; Midazolam; Avoidance inhibitory; Mice; Neurociência; Memória

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pereira, B. C. (2012). Avaliação da memória emocional em camundongos : efeito da injeção de midazolam na substância cinzenta periaquedutal. (Thesis). Universidade Federal de São Carlos. Retrieved from http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=6220

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pereira, Barbara Caetano. “Avaliação da memória emocional em camundongos : efeito da injeção de midazolam na substância cinzenta periaquedutal.” 2012. Thesis, Universidade Federal de São Carlos. Accessed March 06, 2021. http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=6220.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pereira, Barbara Caetano. “Avaliação da memória emocional em camundongos : efeito da injeção de midazolam na substância cinzenta periaquedutal.” 2012. Web. 06 Mar 2021.

Vancouver:

Pereira BC. Avaliação da memória emocional em camundongos : efeito da injeção de midazolam na substância cinzenta periaquedutal. [Internet] [Thesis]. Universidade Federal de São Carlos; 2012. [cited 2021 Mar 06]. Available from: http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=6220.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pereira BC. Avaliação da memória emocional em camundongos : efeito da injeção de midazolam na substância cinzenta periaquedutal. [Thesis]. Universidade Federal de São Carlos; 2012. Available from: http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=6220

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

10. Cilene Aparecida Barbalho Girotti. O papel dos receptores GABAA-benzodiazepínicos da amídala na modulação da antinocicepção e de comportamentos defensivos em camundongos submetidos ao teste de exposição ao rato.

Degree: 2012, Universidade Federal de São Carlos

URL: http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=6711

► Modelos animais têm sido amplamente utilizados para investigar a neurobiologia da ansiedade, medo, bem como, para avaliar a antinocicepção induzida pela ansiedade/medo. Neste sentido, o… (more)

▼ Modelos animais têm sido amplamente utilizados para investigar a neurobiologia da ansiedade, medo, bem como, para avaliar a antinocicepção induzida pela ansiedade/medo. Neste sentido, o teste de exposição ao rato promove na presa (camundongo) intensa resposta defensiva, esquiva e antinocicepção. Vários trabalhos têm demonstrado que agonistas dos receptores GABAA-Benzodiazepínicos, como por exemplo, o midazolam injetado na amídala, pode modular este tipo de antinocicepção induzida pela ansiedade/medo e as reações de defesa em roedores. Entretanto, permanece desconhecido o papel dos receptores GABAAbenzodiazepínicos da amídala na modulação da antinocicepção induzida em camundongos pelo teste de exposição ao rato. Para isso utilizamos camundongos machos, da linhagem Suíço Albino (n= 6-11/grupo), com implantação de cânulas guia na amídala. Após a recuperação da cirurgia e administração dos respectivos fármacos, os animais receberam injeção intraperitoneal de ácido acético (0,6%, 0,1 ml/10g peso) e foram submetidos ao teste de exposição ao rato. O aparato consiste de uma caixa retangular de madeira (59 x 29 x 18 cm), dividida em três compartimentos, sendo o lado A: local de alojamento do rato (20 x 29 x 18 cm); o lado B: área para exploração pelo camundongo (29 x 29 x 18 cm), separada do compartimento A por uma grade de arame, e lado C: área de fuga do camundongo (10 x 29 x 18 cm). O registro do número total de contorções abdominais e das contorções desprotegidas foi utilizado como índice nociceptivo. As medidas de ansiedade/medo utilizadas foram a latência de fuga para a área protegida, o total de entradas (TE), as porcentagens de entradas (%EP) e de tempo gasto no compartimento protegido (%TP), os comportamentos de levantar e o contato com a grade. Os resultados foram avaliados pela análise de variância de dois fatores, fator 1 [tipo de exposição (rato de brinquedo ou rato)] e fator 2 (tratamento). Os valores de p≤ 0,05 foram considerados significativos. Os camundongos foram distribuídos em dois experimentos. No Experimento 1, a administração intra-amídala de midazolam (3,0 e 30 nmol/0,1μL) aumentou o número total de contorções e as contorções desprotegidas em camundongos submetidos ao teste de exposição de rato. Para as medidas de avaliação de risco, o midazolam aumentou o tempo e a frequência de esticar, contado com a grade e a frequência de levantar desprotegido. No Experimento 2, os camundongos receberam injeção combinada de veículo+salina, salina+midazolam (30 nmol/0,1μL), flumazenil (2,0 nmol/0,1μL)+veículo e flumazenil (2,0 nmol/0,1μL)+midazolam (30 nmol/0,1μL). A injeção combinada de salina e midazolam (30 nmol) promoveu aumento da nocicepção e efeito ansiolítico, semelhante ao descrito no Experimento 1. Entretanto, a injeção combinada de flumazenil (2,0 nmol) e midazolam (30 nmol) reverteu o efeito ansiolítico e nociceptivo produzido pelo midazolam em camundongos expostos ao rato. Este estudo mostrou que o modelo de exposição da presa (camundongo) ao predador (rato) foi eficiente… Advisors/Committee Members: Azair Liane Matos do Canto de Souza.

Subjects/Keywords: Neurologia; Amídala; Teste de exposição ao rato; FISIOLOGIA; Midazolam; Flumazenil; Antinocicepção; amygdala; midazolam; flumazenil; rat exposure test; antinociception; anxiety

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Girotti, C. A. B. (2012). O papel dos receptores GABAA-benzodiazepínicos da amídala na modulação da antinocicepção e de comportamentos defensivos em camundongos submetidos ao teste de exposição ao rato. (Thesis). Universidade Federal de São Carlos. Retrieved from http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=6711

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Girotti, Cilene Aparecida Barbalho. “O papel dos receptores GABAA-benzodiazepínicos da amídala na modulação da antinocicepção e de comportamentos defensivos em camundongos submetidos ao teste de exposição ao rato.” 2012. Thesis, Universidade Federal de São Carlos. Accessed March 06, 2021. http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=6711.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Girotti, Cilene Aparecida Barbalho. “O papel dos receptores GABAA-benzodiazepínicos da amídala na modulação da antinocicepção e de comportamentos defensivos em camundongos submetidos ao teste de exposição ao rato.” 2012. Web. 06 Mar 2021.

Vancouver:

Girotti CAB. O papel dos receptores GABAA-benzodiazepínicos da amídala na modulação da antinocicepção e de comportamentos defensivos em camundongos submetidos ao teste de exposição ao rato. [Internet] [Thesis]. Universidade Federal de São Carlos; 2012. [cited 2021 Mar 06]. Available from: http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=6711.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Girotti CAB. O papel dos receptores GABAA-benzodiazepínicos da amídala na modulação da antinocicepção e de comportamentos defensivos em camundongos submetidos ao teste de exposição ao rato. [Thesis]. Universidade Federal de São Carlos; 2012. Available from: http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=6711

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

11. Silva, Carolina de Miranda. Influência da função renal na farmacocinética dos enantiômeros da ciclofosfamida em pacientes portadores de nefrite lúpica.

Degree: PhD, Toxicologia, 2010, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/60/60134/tde-09062010-122214/ ;

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A farmacocinética dos enantiômeros da ciclofosfamida (CPA) foi avaliada em pacientes portadores de nefrite lúpica distribuídos em dois grupos de acordo com o clearance da… (more)

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A farmacocinética dos enantiômeros da ciclofosfamida (CPA) foi avaliada em pacientes portadores de nefrite lúpica distribuídos em dois grupos de acordo com o clearance da creatinina: Grupo 1 90,6-144,6mL/min/1,73m2 e Grupo 2 42,8-76,4mL/min/1,73m2. Os pacientes foram tratados com doses de 0,75 a 1,3g de ciclofosfamida racêmica sob forma de infusão com duração de 2h e com 1mg de midazolam (MDZ) administrado via endovenosa para a avaliação da atividade in vivo do CYP3A. As concentrações plasmáticas dos enantiômeros da CPA e do MDZ foram avaliadas por LC-MS/MS. Os enantiômeros da CPA foram resolvidos na coluna Chiralcel OD-R, com fase móvel constituída por mistura de acetonitrila e água (75:25, v/v) adicionada de 0,2% de ácido fórmico. Os enantiômeros da CPA foram extraídos do plasma com recuperações maiores que 95% e o limite de quantificação obtido foi de 2,5ng de cada enantiômero da CPA/mL plasma. As seguintes diferenças (teste de Wilcoxon, p<0,05) foram observadas nos parâmetros farmacocinéticos entre os enantiômeros (S)-(-)-CPA e (R)-(+)-CPA para os pacientes do Grupo 1: AUC do tempo 0 ao infinito 152,41 vs 129,25g.h/mL; Cl 3,28 vs 3,89L/h; Vd 31,38 vs 29,74L e t1/2 6,79 vs 5,56h e para os pacientes do Grupo 2: AUC do tempo 0 ao infinito 167,20 vs 139,08g.h/mL; Cl 2,99 vs 3,59L/h e t1/2 6,15 vs 4,99h. Não foi observada diferença (teste de Mann-Whitney, p<0,05) nos parâmetros farmacocinéticos de ambos os enantiômeros entre os grupos 1 e 2. Não foi observada corrrelação entre o clearance do MDZ (2,92-16,40ml/min.kg) e o clearance de cada enantiômero da CPA. Concluindo, a farmacocinética da CPA é enantiosseletiva em pacientes portadores de nefrite lúpica com acúmulo plasmático do enantiômero (S)-(-)-CPA e a farmacocinética de ambos os enantiômeros da CPA não é alterada pela agravamento da função renal.

The pharmacokinetics of cyclophosphamide (CYC) enantiomers was evaluated in patients with lupus nephritis distributed in two groups according to creatinine clearance; Group 1 - 90.6-144.6mL/min/1.73m2 and Group 2 - 42.8- 76.4mL/min/1.73m2. All patients were treated with 0.75 to 1.3g of racemic CYC as a 2-hour infusion and with 1mg intravenous midazolam as a drug marker. CYC enantiomers and midazolam concentrations in plasma were measured by LC-MS/MS. CYC enantiomers were separated on a Chiralcel OD-R column, with the mobile phase consisting of a mixture of acetonitrile and water (75:25, v/v) plus 0.2% formic acid. Recovery rates were higher than 95% and the quantification limit was 2.5ng/ml plasma for both enantiomers. The coefficients of variation and the relative errors obtained for the validation of intra- and interassay precision and accuracy were less than 10%. The following differences in the pharmacokinetic parameters (Wilcoxon test, p<0.05) were observed between the (S)-(-) and (R)-(+) enantiomers for Group 1 AUC from time 0 to infinity 152.41 vs 129.25g.h/mL, Cl 3.28 vs 3.89L/h, Vd 31.38 vs 29.74L and t1/2 6.79 vs 5.56h and for Group 2 AUC from time 0 to infinity 167.20 vs 139.08g.h/mL, Cl 2.99 vs 3.59 L/h…

Advisors/Committee Members: Lanchote, Vera Lucia.

Subjects/Keywords: Ciclofosfamida; cyclophosphamide; Enantiômeros; enantiomers; Farmacocinética; lupus nephritis; midazolam; pharmacokinetics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Silva, C. d. M. (2010). Influência da função renal na farmacocinética dos enantiômeros da ciclofosfamida em pacientes portadores de nefrite lúpica. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/60/60134/tde-09062010-122214/ ;

Chicago Manual of Style (16^th Edition):

Silva, Carolina de Miranda. “Influência da função renal na farmacocinética dos enantiômeros da ciclofosfamida em pacientes portadores de nefrite lúpica.” 2010. Doctoral Dissertation, University of São Paulo. Accessed March 06, 2021. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-09062010-122214/ ;.

MLA Handbook (7^th Edition):

Silva, Carolina de Miranda. “Influência da função renal na farmacocinética dos enantiômeros da ciclofosfamida em pacientes portadores de nefrite lúpica.” 2010. Web. 06 Mar 2021.

Vancouver:

Silva CdM. Influência da função renal na farmacocinética dos enantiômeros da ciclofosfamida em pacientes portadores de nefrite lúpica. [Internet] [Doctoral dissertation]. University of São Paulo; 2010. [cited 2021 Mar 06]. Available from: http://www.teses.usp.br/teses/disponiveis/60/60134/tde-09062010-122214/ ;.

Council of Science Editors:

Silva CdM. Influência da função renal na farmacocinética dos enantiômeros da ciclofosfamida em pacientes portadores de nefrite lúpica. [Doctoral Dissertation]. University of São Paulo; 2010. Available from: http://www.teses.usp.br/teses/disponiveis/60/60134/tde-09062010-122214/ ;

Kyoto University / 京都大学

12. Matsuyama, Tomonori. Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system : ミダゾラムは低酸素に誘導される脳内エリスロポイエチン発現上昇を抑制する.

Degree: 博士(医学), 2015, Kyoto University / 京都大学

URL: http://hdl.handle.net/2433/202803 ; http://dx.doi.org/10.14989/doctor.k19369

新制・課程博士

甲第19369号

医博第4046号

Subjects/Keywords: Midazolam; Erythropoietin; Hypoxia-inducible factor

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APA (6^th Edition):

Matsuyama, T. (2015). Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system : ミダゾラムは低酸素に誘導される脳内エリスロポイエチン発現上昇を抑制する. (Thesis). Kyoto University / 京都大学. Retrieved from http://hdl.handle.net/2433/202803 ; http://dx.doi.org/10.14989/doctor.k19369

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Matsuyama, Tomonori. “Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system : ミダゾラムは低酸素に誘導される脳内エリスロポイエチン発現上昇を抑制する.” 2015. Thesis, Kyoto University / 京都大学. Accessed March 06, 2021. http://hdl.handle.net/2433/202803 ; http://dx.doi.org/10.14989/doctor.k19369.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Matsuyama, Tomonori. “Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system : ミダゾラムは低酸素に誘導される脳内エリスロポイエチン発現上昇を抑制する.” 2015. Web. 06 Mar 2021.

Vancouver:

Matsuyama T. Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system : ミダゾラムは低酸素に誘導される脳内エリスロポイエチン発現上昇を抑制する. [Internet] [Thesis]. Kyoto University / 京都大学; 2015. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/2433/202803 ; http://dx.doi.org/10.14989/doctor.k19369.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Matsuyama T. Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system : ミダゾラムは低酸素に誘導される脳内エリスロポイエチン発現上昇を抑制する. [Thesis]. Kyoto University / 京都大学; 2015. Available from: http://hdl.handle.net/2433/202803 ; http://dx.doi.org/10.14989/doctor.k19369

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. Lucianna Pereira da Motta Pires Correia. Propofol e fentanil versus midazolam e fentanil para sedação em pacientes cirróticos durante a realização de endoscopia digestiva alta.

Degree: 2012, Universidade Federal de São Paulo

URL: http://www.bdtd.unifesp.br/tede//tde_busca/arquivo.php?codArquivo=2149

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Introdução: Pacientes cirróticos frequentemente são submetidos a procedimentos de endoscopia digestiva alta diagnóstica ou terapêutica. A cirrose hepática pode prejudicar o metabolismo das drogas utilizadas… (more)

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Introdução: Pacientes cirróticos frequentemente são submetidos a procedimentos de endoscopia digestiva alta diagnóstica ou terapêutica. A cirrose hepática pode prejudicar o metabolismo das drogas utilizadas para sedação devido às alterações de função hepática, com possíveis consequências para a eficácia e a segurança durante os procedimentos. Idealizamos um estudo comparando dois esquemas para sedação durante endoscopia digestiva neste grupo de pacientes: propofol associado a fentanil e midazolam associado a fentanil. Objetivos: comparar os dois esquemas de sedação propostos quanto à eficácia (proporção de exames completos realizados com o esquema inicialmente proposto), segurança (ocorrência de complicações relacionadas à sedação) e tempo de recuperação (definido como tempo entre o término do exame endoscópico e a alta ambulatorial). Pacientes e método: realizamos estudo prospectivo aleatorizado no período de fevereiro de 2008 a fevereiro de 2009. Foram incluídos para análise 210 pacientes cirróticos ambulatoriais, distribuídos em dois grupos: Grupo Midazolam (110 pacientes) e Grupo Propofol (100 pacientes). A dose inicialmente proposta de sedação foi, para o grupo Midazolam, 0,05 mg/kg associado a fentanil, 50 μg, por via intravenosa; e para o grupo Propofol, 0,5mg/kg associado a fentanil, 50 μg, por via intravenosa. Resultados: Não houve diferença entre os grupos quando comparados em relação à idade, sexo, peso, etiologia da cirrose, classificação de Child-Pugh ou ASA, bem como em relação ao tipo de procedimento endoscópico realizado (exame diagnóstico, ligadura elástica ou escleroterapia de varizes). A sedação com propofol e fentanil mostrou-se mais eficaz (100% vs. 88.2% - p <0,001) e com menor tempo de recuperação que a sedação com midazolam associado a fentanil (16,23 DP 6,84 min vs. 27,40 DP 17,19 min, respectivamente - p <0,001). A ocorrência de complicações foi semelhante nos dois grupos (14% vs. 7,3% - p = 0,172). Conclusão: Ambos os esquemas mostraram-se seguros. A sedação com propofol e fentanil foi mais eficaz e apresentou tempo de recuperação mais curto quando comparado ao midazolam associado ao fentanil. Propofol deve ser considerado como alternativa para sedação durante endoscopia digestiva alta em pacientes cirróticos ambulatoriais.

Background: Cirrhotic patients often undergo diagnostic or therapeutic upper gastrointestinal endoscopy. The liver cirrhosis might impair the metabolism of drugs used to sedation due to changes in liver function, with possible consequences for the efficacy and safety during procedures. We designed a study to compare two regimens for sedation during endoscopy in this group of patients: propofol with fentanyl and midazolam with fentanyl. Objectives: To compare the two schemes proposed regarding the sedation efficacy (proportion of complete procedures using the initial proposed scheme), safety (occurrence of sedation-related complications) and recovery time (defined as time between the end of the procedure and ambulatory discharge). Patients and methods: We…

Advisors/Committee Members: Maria Rachel da Silveira Rohr, Fauze Maluf Filho, Adriana Vaz Safatle-Ribeiro, Maria Lucia Cardoso Gomes Ferraz, Gustavo Andrade de Paula, Ermelindo Della Libera Junior.

Subjects/Keywords: Midazolam; Propofol; Sedação; Endoscopia Digestiva Alta; Cirrose hepática; GASTROENTEROLOGIA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Correia, L. P. d. M. P. (2012). Propofol e fentanil versus midazolam e fentanil para sedação em pacientes cirróticos durante a realização de endoscopia digestiva alta. (Thesis). Universidade Federal de São Paulo. Retrieved from http://www.bdtd.unifesp.br/tede//tde_busca/arquivo.php?codArquivo=2149

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Correia, Lucianna Pereira da Motta Pires. “Propofol e fentanil versus midazolam e fentanil para sedação em pacientes cirróticos durante a realização de endoscopia digestiva alta.” 2012. Thesis, Universidade Federal de São Paulo. Accessed March 06, 2021. http://www.bdtd.unifesp.br/tede//tde_busca/arquivo.php?codArquivo=2149.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Correia, Lucianna Pereira da Motta Pires. “Propofol e fentanil versus midazolam e fentanil para sedação em pacientes cirróticos durante a realização de endoscopia digestiva alta.” 2012. Web. 06 Mar 2021.

Vancouver:

Correia LPdMP. Propofol e fentanil versus midazolam e fentanil para sedação em pacientes cirróticos durante a realização de endoscopia digestiva alta. [Internet] [Thesis]. Universidade Federal de São Paulo; 2012. [cited 2021 Mar 06]. Available from: http://www.bdtd.unifesp.br/tede//tde_busca/arquivo.php?codArquivo=2149.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Correia LPdMP. Propofol e fentanil versus midazolam e fentanil para sedação em pacientes cirróticos durante a realização de endoscopia digestiva alta. [Thesis]. Universidade Federal de São Paulo; 2012. Available from: http://www.bdtd.unifesp.br/tede//tde_busca/arquivo.php?codArquivo=2149

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. Cabalo, Manuel Moledo. SEDAÇAO CONSCIENTE CON MIDAZOLAM ORAL E SUBLINGUAL EM ADULTOS.

Degree: 2017, RCAAP

URL: https://www.rcaap.pt/detail.jsp?id=oai:repositorio.cespu.pt:20.500.11816/2817

► A fim de localizar publicações relacionadas com o assunto deste relatório final de estágio, realizou-se uma pesquisa na base de dados Pubmed e os temas… (more)

Subjects/Keywords: Midazolam; Sedação oral; Vía sublingual; Ansiedade em odontologia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cabalo, M. M. (2017). SEDAÇAO CONSCIENTE CON MIDAZOLAM ORAL E SUBLINGUAL EM ADULTOS. (Thesis). RCAAP. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:repositorio.cespu.pt:20.500.11816/2817

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cabalo, Manuel Moledo. “SEDAÇAO CONSCIENTE CON MIDAZOLAM ORAL E SUBLINGUAL EM ADULTOS.” 2017. Thesis, RCAAP. Accessed March 06, 2021. https://www.rcaap.pt/detail.jsp?id=oai:repositorio.cespu.pt:20.500.11816/2817.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cabalo, Manuel Moledo. “SEDAÇAO CONSCIENTE CON MIDAZOLAM ORAL E SUBLINGUAL EM ADULTOS.” 2017. Web. 06 Mar 2021.

Vancouver:

Cabalo MM. SEDAÇAO CONSCIENTE CON MIDAZOLAM ORAL E SUBLINGUAL EM ADULTOS. [Internet] [Thesis]. RCAAP; 2017. [cited 2021 Mar 06]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:repositorio.cespu.pt:20.500.11816/2817.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cabalo MM. SEDAÇAO CONSCIENTE CON MIDAZOLAM ORAL E SUBLINGUAL EM ADULTOS. [Thesis]. RCAAP; 2017. Available from: https://www.rcaap.pt/detail.jsp?id=oai:repositorio.cespu.pt:20.500.11816/2817

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Commonwealth University

15. Henderson, Brett H. Comparison of Triple Combination Oral Sedation Regimens for Pediatric Dental Treatment.

Degree: MSin Dentistry, Dentistry, 2019, Virginia Commonwealth University

URL: https://doi.org/10.25772/D628-HC25 ; https://scholarscompass.vcu.edu/etd/5785

► Purpose: Compare the efficacy of two benzodiazepines (diazepam or midazolam) in combination with meperidine and hydroxyzine for pediatric dental sedation. Methods: A randomized, double… (more)

Subjects/Keywords: Sedation; Pediatric Dentistry; Diazepam; Midazolam; Meperidine; Hydroxyzine; Pediatric Dentistry and Pedodontics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Henderson, B. H. (2019). Comparison of Triple Combination Oral Sedation Regimens for Pediatric Dental Treatment. (Thesis). Virginia Commonwealth University. Retrieved from https://doi.org/10.25772/D628-HC25 ; https://scholarscompass.vcu.edu/etd/5785

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Henderson, Brett H. “Comparison of Triple Combination Oral Sedation Regimens for Pediatric Dental Treatment.” 2019. Thesis, Virginia Commonwealth University. Accessed March 06, 2021. https://doi.org/10.25772/D628-HC25 ; https://scholarscompass.vcu.edu/etd/5785.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Henderson, Brett H. “Comparison of Triple Combination Oral Sedation Regimens for Pediatric Dental Treatment.” 2019. Web. 06 Mar 2021.

Vancouver:

Henderson BH. Comparison of Triple Combination Oral Sedation Regimens for Pediatric Dental Treatment. [Internet] [Thesis]. Virginia Commonwealth University; 2019. [cited 2021 Mar 06]. Available from: https://doi.org/10.25772/D628-HC25 ; https://scholarscompass.vcu.edu/etd/5785.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Henderson BH. Comparison of Triple Combination Oral Sedation Regimens for Pediatric Dental Treatment. [Thesis]. Virginia Commonwealth University; 2019. Available from: https://doi.org/10.25772/D628-HC25 ; https://scholarscompass.vcu.edu/etd/5785

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of the Western Cape

16. Carstens, Hendrik Andries. The management of a safe and cost effective conscious sedation unit .

Degree: 2016, University of the Western Cape

URL: http://hdl.handle.net/11394/5276

► Conscious sedation or moderate sedation and analgesia is an effective and popular alternative option for procedures outside the operating theater. If conscious sedation is a… (more)

▼ Conscious sedation or moderate sedation and analgesia is an effective and popular alternative option for procedures outside the operating theater. If conscious sedation is a viable alternative to general anaesthesia then we as sedation practitioners must use safe sedation techniques in facilities that meet all the requirements for safe practice. Three studies were done to determine the safety and efficacy of conscious sedation outside the operating theatre. In the first study post sedation satisfaction in one hundred children aged 3-9 years was evaluated. It was extremely important to determine whether the combination of midazolam, ketamine and propofol, called an advanced sedation technique (SASA, 2015), can be safely used for paediatric sedation outside the operating theatre. The incidence of side-effects after conscious sedation using multiple drugs were documented. It is clear that intravenous sedation with midazolam, ketamine and propofol is safe and effective to use. There may be side effects but they are not long lasting and usually not life-threatening. In the second study intravenous sedation was administered to 447 adults (aged 18 years and older) using fentanyl (sublimazeR), ketamine (ketalar), midazolam (dormicum) and propofol (Diprivan) (FKMP) called an advanced sedation technique. Post sedation satisfaction, post sedation recovery on arrival home, and the relationship between side effects and different dental procedures were evaluated. The results of the study show that side effects are possible, and can be expected, when we use sedative and analgesic drugs for sedation. However, we report a low incidence of side effects when we compare it with other studies in literature as mentioned. It is known that the use of combinations of drugs may cause unforeseen synergistic pharmacological effects which can be lifethreatening. Our results show that the drugs used can be safely used for advanced sedation techniques. In trying to demonstrate the safety of sedative and analgesic agents used during sedation we looked at the haemodynamic parameters, duration of sedation, pulse rate and systolic blood pressure, in the third study. The sedation records of 335 patients for dental surgery were assessed for the period 2010 – 2011. Our results show the mean Duration of sedation is substantially and statistically significantly greater with combination FKMP than with the other combinations. The mean duration of sedation is not significantly different between ketamine and propofol (KP) and fentanyl, ketamine and propofol (FKP) (Figure 10). The use of polypharmacy regarding the combination of drugs, specifically FKMP, will cause a longer duration of sedation. This has implications for safety, as well as the side effect profile during and after sedation. When we use combinations of drugs patients were more comfortable which shows that we do not yet have a single drug that has all the characteristics of an ideal drug for sedation. Different combinations of drugs are used by other practitioners with a higher incidence of… Advisors/Committee Members: Roelofse, James (advisor).

Subjects/Keywords: Conscious sedation; Midazolam; Ketamine; Propofol; Drugs – Side effects

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Carstens, H. A. (2016). The management of a safe and cost effective conscious sedation unit . (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/5276

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Carstens, Hendrik Andries. “The management of a safe and cost effective conscious sedation unit .” 2016. Thesis, University of the Western Cape. Accessed March 06, 2021. http://hdl.handle.net/11394/5276.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Carstens, Hendrik Andries. “The management of a safe and cost effective conscious sedation unit .” 2016. Web. 06 Mar 2021.

Vancouver:

Carstens HA. The management of a safe and cost effective conscious sedation unit . [Internet] [Thesis]. University of the Western Cape; 2016. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/11394/5276.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Carstens HA. The management of a safe and cost effective conscious sedation unit . [Thesis]. University of the Western Cape; 2016. Available from: http://hdl.handle.net/11394/5276

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Guelph

17. Liao, PenTing. ANESTHETIC AND CARDIO-PULMONARY EFFECTS OF PROPOFOL OR ALFAXALONE WITH OR WITHOUT MIDAZOLAM CO-INDUCTION IN FENTANYL SEDATED DOGS.

Degree: Doctor of Veterinary Science, Department of Clinical Studies, 2016, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9991

► This thesis describes a prospective, randomized, incomplete Latin-square crossover, blind trial to investigate the effects of midazolam (M) as a co-induction agent in dogs induced… (more)

▼ This thesis describes a prospective, randomized, incomplete Latin-square crossover, blind trial to investigate the effects of midazolam (M) as a co-induction agent in dogs induced and maintained with propofol (P) or alfaxalone (A) for diagnostic imaging. The quality of induction and recovery, induction and maintenance dose requirements for P or A, ease of maintenance using total intravenous anesthesia (TIVA), and cardio-pulmonary effects were determined in ten dogs assigned to P-S: P with saline (S); A-S: A with S; P-M: P with M; A-M: A with M. Fentanyl (7 µg kg-1, IV) was administered 10 minutes prior to an IV bolus of P (1 mg kg-1) or A (0.5 mg kg-1) followed by M (0.3 mg kg-1, IV) or S and additional boluses of P or A for intubation, followed by P or A TIVA during imaging. The induction quality was significantly better in A-M versus A-S, P-M versus P-S, and A-M versus P-S. The induction dose was significantly lower in P-M versus P-S, and A-M versus A-S. The TIVA rate with P-M was significantly lower than P-S but similar between A-M and A-S. Sedation, extubation and recovery quality, and TIVA duration were similar between treatments. Time to standing was significantly longer for A than P, but was similar within A or P treatments. After induction, heart rate (HR) was significantly higher in A-M than A-S and P-S. During imaging, HR of A-S and A-M were significantly higher than P-S. Before recovery, HR of A-M was significantly higher than P-S. Systolic blood pressure of A-S was significantly higher than A-M and P-M. There was no significant treatment difference for mean or diastolic blood pressure, cardiac index (CI), respiratory rate, occurrence of apnea, end-tidal CO2, and blood gas values. However, CI and HR significantly decreased after imaging compared to other phases. Midazolam improved the quality and reduced the required dose for both P and A induction, and reduced TIVA rate of P. There was no significant cardiopulmonary difference identified between treatments despite co-induction with M. The decrease in CI and HR after imaging warrants close monitoring during recovery. Advisors/Committee Members: Sinclair, Melissa (advisor).

Subjects/Keywords: anesthesia; propofol; alfaxalone; midazolam; dog; TIVA; induction; coinduction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Liao, P. (2016). ANESTHETIC AND CARDIO-PULMONARY EFFECTS OF PROPOFOL OR ALFAXALONE WITH OR WITHOUT MIDAZOLAM CO-INDUCTION IN FENTANYL SEDATED DOGS. (Doctoral Dissertation). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9991

Chicago Manual of Style (16^th Edition):

Liao, PenTing. “ANESTHETIC AND CARDIO-PULMONARY EFFECTS OF PROPOFOL OR ALFAXALONE WITH OR WITHOUT MIDAZOLAM CO-INDUCTION IN FENTANYL SEDATED DOGS.” 2016. Doctoral Dissertation, University of Guelph. Accessed March 06, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9991.

MLA Handbook (7^th Edition):

Liao, PenTing. “ANESTHETIC AND CARDIO-PULMONARY EFFECTS OF PROPOFOL OR ALFAXALONE WITH OR WITHOUT MIDAZOLAM CO-INDUCTION IN FENTANYL SEDATED DOGS.” 2016. Web. 06 Mar 2021.

Vancouver:

Liao P. ANESTHETIC AND CARDIO-PULMONARY EFFECTS OF PROPOFOL OR ALFAXALONE WITH OR WITHOUT MIDAZOLAM CO-INDUCTION IN FENTANYL SEDATED DOGS. [Internet] [Doctoral dissertation]. University of Guelph; 2016. [cited 2021 Mar 06]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9991.

Council of Science Editors:

Liao P. ANESTHETIC AND CARDIO-PULMONARY EFFECTS OF PROPOFOL OR ALFAXALONE WITH OR WITHOUT MIDAZOLAM CO-INDUCTION IN FENTANYL SEDATED DOGS. [Doctoral Dissertation]. University of Guelph; 2016. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9991

University of Debrecen

18. Odum, Noble Chidinma. The use of midazolam in spinal anesthesia .

Degree: DE – Általános Orvostudományi Kar, University of Debrecen

URL: http://hdl.handle.net/2437/263475

► When midazolam is combined with bipuvicaine, it produced a more efficient anesthesia with a longer duration than when bipuvicaine alone was administered. This was achieved… (more)

Subjects/Keywords: Midazolam; Spinal anesthesia; premedication

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APA (6^th Edition):

Odum, N. C. (n.d.). The use of midazolam in spinal anesthesia . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/263475

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Odum, Noble Chidinma. “The use of midazolam in spinal anesthesia .” Thesis, University of Debrecen. Accessed March 06, 2021. http://hdl.handle.net/2437/263475.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Odum, Noble Chidinma. “The use of midazolam in spinal anesthesia .” Web. 06 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Odum NC. The use of midazolam in spinal anesthesia . [Internet] [Thesis]. University of Debrecen; [cited 2021 Mar 06]. Available from: http://hdl.handle.net/2437/263475.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Odum NC. The use of midazolam in spinal anesthesia . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/263475

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Central Connecticut State University

19. Foley, Ann T. Effects of prophylactic intravenous midazolam on postoperative succinylcholine-induced myalgia.

Degree: Department of Biological Sciences, 1990, Central Connecticut State University

URL: http://content.library.ccsu.edu/u?/ccsutheses,2866

►

The purpose of this study was to determine whether small, pretreatment doses of midazolam would prevent postoperative succinylcholine-induced muscle pain. This research compared the effects… (more)

Subjects/Keywords: Midazolam – Research.; Myalgia – Research.

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APA (6^th Edition):

Foley, A. T. (1990). Effects of prophylactic intravenous midazolam on postoperative succinylcholine-induced myalgia. (Thesis). Central Connecticut State University. Retrieved from http://content.library.ccsu.edu/u?/ccsutheses,2866

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Foley, Ann T. “Effects of prophylactic intravenous midazolam on postoperative succinylcholine-induced myalgia.” 1990. Thesis, Central Connecticut State University. Accessed March 06, 2021. http://content.library.ccsu.edu/u?/ccsutheses,2866.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Foley, Ann T. “Effects of prophylactic intravenous midazolam on postoperative succinylcholine-induced myalgia.” 1990. Web. 06 Mar 2021.

Vancouver:

Foley AT. Effects of prophylactic intravenous midazolam on postoperative succinylcholine-induced myalgia. [Internet] [Thesis]. Central Connecticut State University; 1990. [cited 2021 Mar 06]. Available from: http://content.library.ccsu.edu/u?/ccsutheses,2866.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Foley AT. Effects of prophylactic intravenous midazolam on postoperative succinylcholine-induced myalgia. [Thesis]. Central Connecticut State University; 1990. Available from: http://content.library.ccsu.edu/u?/ccsutheses,2866

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. Rebatti, Lava Asi. Premedicinering av barn : - en jämförelse mellan alfa-2-adrenoceptoragonister ochmidazolam.

Degree: Pharmacology, 2016, Umeå University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-119228

► Premedicinering innebär att en patient behandlas med lugnande läkemedel inför enoperation eller ett ingrepp för att dämpa dennes oro och smärta. Inom den pediatriskapopulationen… (more)

▼ Premedicinering innebär att en patient behandlas med lugnande läkemedel inför enoperation eller ett ingrepp för att dämpa dennes oro och smärta. Inom den pediatriskapopulationen är detta vanligt då yngre patienter kan uppleva oro eftersom de inte alltidförstår syftet med ingreppet och kan känna rädsla då de ska separeras från sinaföräldrar. Bensodiazepinet midazolam har länge använts inom premedicinering tillbarn och har väl dokumenterad effekt. Det har dock påvisats att läkemedlet kan geupphov till så kallade paradoxala reaktioner, en biverkan som innebär att barnen fåroväntade reaktioner i form av t ex agitation. Det har därför föreslagits att substansenbör ersättas med alfa-2-adrenoceptoragonister som t ex klonidin eller dexmedetomidin,vilka har samma indikationer som midazolam, men utan att orsaka paradoxalareaktioner. Syftet med detta examensarbete är att undersöka om alfa-2-adrenoceptoragonister äröverlägsna midazolam vid premedicinering av barn. Arbetet är en litteraturstudie somfrämst jämfört resultaten från kliniska prövningar av olika läkemedelsbehandlingar isamband med premedicinering av barn avseende effekt och kvalitet, samt uppkomst avbiverkningar mellan de tre substanserna midazolam, klonidin och dexmedetomidin. Deprimära parametrar som jämförts är sedationsdjup, tillslagstid, substansernasanxiolytiska effekt och återhämtningsprofil. De sekundära parametrarna är hanteringav separation från föräldrar, föräldrarnas betyg samt läkemedels-/maskacceptans. Resultatet visar att de två alfa-2-adrenoceptoragonisterna klonidin ochdexmedetomidin är bättre än midazolam vad gäller sedationsdjup, separation frånföräldrar, läkemedelsacceptans och återhämtningsprofil, samt var denläkemedelsgrupp som gavs högst betyg av föräldrarna. Anxiolytisk effekt ochmaskacceptans var likvärdiga mellan de två grupperna, medan midazolam hadesnabbast tillslagstid. Paradoxala reaktioner förekom i relativt hög frekvens vidmidazolamsedering, medan alfa-2-adrenoceptoragonisterna gav biverkningar i form avhemodynamiska förändringar som sänkt blodtryck och puls. Avslutningsvis visar resultaten i denna studie att alfa-2-adrenoceptoragonister är attföredra framför midazolam. Speciellt avsaknaden av paradoxala reaktioner vid sederingmed alfa-2-adrenoceptoragonister gör att den gruppen av läkemedel har en stor fördelframför midazolam vid sedering av barn. Men i de fall där barnet har hemodynamiskabesvär i form av exempelvis bradykardi, bör man undvika alfa-2-adrenoceptoragonisteroch istället premedicinera med midazolam.

Subjects/Keywords: premedicinering; barn; midazolam; klonidin; dexmedetomidin; Pharmaceutical Sciences; Farmaceutiska vetenskaper

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rebatti, L. A. (2016). Premedicinering av barn : - en jämförelse mellan alfa-2-adrenoceptoragonister ochmidazolam. (Thesis). Umeå University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-119228

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rebatti, Lava Asi. “Premedicinering av barn : - en jämförelse mellan alfa-2-adrenoceptoragonister ochmidazolam.” 2016. Thesis, Umeå University. Accessed March 06, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-119228.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rebatti, Lava Asi. “Premedicinering av barn : - en jämförelse mellan alfa-2-adrenoceptoragonister ochmidazolam.” 2016. Web. 06 Mar 2021.

Vancouver:

Rebatti LA. Premedicinering av barn : - en jämförelse mellan alfa-2-adrenoceptoragonister ochmidazolam. [Internet] [Thesis]. Umeå University; 2016. [cited 2021 Mar 06]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-119228.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rebatti LA. Premedicinering av barn : - en jämförelse mellan alfa-2-adrenoceptoragonister ochmidazolam. [Thesis]. Umeå University; 2016. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-119228

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of the Western Cape

21. Mahgoub, Ahmed Elsheikh Omer. The comparison of two doses of intranasal midazolam sedation in a paediatric dental emergency clinic .

Degree: 2011, University of the Western Cape

URL: http://hdl.handle.net/11394/3534

► The aim of the study was to compare two doses of intranasal midazolam (INM) 0.3 mg/kg and 0.5 mg/kg in terms of effectiveness and recovery… (more)

▼ The aim of the study was to compare two doses of intranasal midazolam (INM) 0.3 mg/kg and 0.5 mg/kg in terms of effectiveness and recovery time. Design:-This study was a Randomized Controlled Trial (RCT) and Triple blinded study. Sample and methods A sample of one hundred and eighteen children aged from 4-6 years old were randomly assigned for Intranasal sedation (INS) to either the 0.3 mg/kg group or the 0.5 mg/kg group. Children were taken in fasting and non-fasting conditions. The children were monitored using a pulse-oximeter, the sedation was assessed using Wilson sedation scale and the anxiety and behaviour scales were rated by Venham’s scale throughout the treatment. The facial image Scale (FIS) was also used to assess anxiety and mood of children before and after treatment. Results The mean BMI of children was found to be from 14-16. Intranasal sedation with both 0.3 mg/kg and 0.5 mg/kg midazolam was completed in 100% of the children. The pulse rates were within normal limit but statistically lower in the 0.5 mg/kg group. Oxygen saturation was above 98% in all except for one child who desaturated to 90%. Thirty five percent found this route acceptable in this study; Nine percent had burning sensation from midazolam. The state anxiety between the two groups of 0.3 mg/kg and 0.5 mg/kg were insignificant using Venham’s scale. However, behaviour scores showed statistical significant results of p value (0.03) and (0.04) in the behaviour during LA and behaviour during extractions respectively. The facial images scale (FIS) ratings chosen by the children before and after sedation was insignificant to the anxiety and behaviour ratings. The FIS revealed that 66% chose a happy face at the end of treatment. Fifty percent of the children in the study chose the same image before and after sedation. There were no adverse events encountered during the procedure. Conclusion INS with midazolam using the 0.3 mg/kg or 0.5 mg/kg doses resulted in safe and effective sedation. The 0.5 mg/kg proved to be more effective than the 0.3 mg/kg in providing better behaviour and decreasing anxiety when compared with the 0.3 mg/kg dose. The 0.5 mg/kg dose was found to be safe and the recovery time was slightly more than the 0.3 mg/kg but the difference was not clinically significant. Advisors/Committee Members: Peerbhay, Fathima (advisor), Roelofse, James (advisor).

Subjects/Keywords: Intranasal; Midazolam; Sedation; Comparison; Anxious; Paediatric; Children; Dental; Emergency; Clinic

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APA (6^th Edition):

Mahgoub, A. E. O. (2011). The comparison of two doses of intranasal midazolam sedation in a paediatric dental emergency clinic . (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/3534

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mahgoub, Ahmed Elsheikh Omer. “The comparison of two doses of intranasal midazolam sedation in a paediatric dental emergency clinic .” 2011. Thesis, University of the Western Cape. Accessed March 06, 2021. http://hdl.handle.net/11394/3534.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mahgoub, Ahmed Elsheikh Omer. “The comparison of two doses of intranasal midazolam sedation in a paediatric dental emergency clinic .” 2011. Web. 06 Mar 2021.

Vancouver:

Mahgoub AEO. The comparison of two doses of intranasal midazolam sedation in a paediatric dental emergency clinic . [Internet] [Thesis]. University of the Western Cape; 2011. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/11394/3534.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mahgoub AEO. The comparison of two doses of intranasal midazolam sedation in a paediatric dental emergency clinic . [Thesis]. University of the Western Cape; 2011. Available from: http://hdl.handle.net/11394/3534

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Louisiana State University

22. Lagos, Angie. Alternative Techniques for Alfaxalone Anesthesia Induction in Dogs and Cats.

Degree: MS, Other Veterinary Medicine, 2018, Louisiana State University

URL: https://digitalcommons.lsu.edu/gradschool_theses/4720

► Alfaxalone is a neuroactive synthetic steroid (Brewster & Bodor, 1990) that produces anesthetic induction with dose- and speed-dependent cardiorespiratory depression in dogs and cats… (more)

▼ Alfaxalone is a neuroactive synthetic steroid (Brewster & Bodor, 1990) that produces anesthetic induction with dose- and speed-dependent cardiorespiratory depression in dogs and cats (Chiu et al. 2016; Warne et al., 2015). At clinical doses in unpremedicated dogs (2 mg kg^-1) and cats (5 mg kg^-1), alfaxalone induces a mild decrease in systemic vascular resistance, systemic blood pressure (Muir et al., 2009; Muir et al., 2008), apnea, hypoventilation, and hypoxemia (Muir et al. 2009; Muir et al., 2008). The cardiorespiratory side effects from alfaxalone induction could be prevented by reducing the total dose of alfaxalone necessary to produce general anesthesia. Therefore, the overall objective of this research dissertation was to investigate the reduction of alfaxalone induction dose by using it in two alternative anesthesia induction techniques, as follows: 1- priming principle of alfaxalone, in dogs and cats, and 2- co-induction of midazolam with a low dose of alfaxalone, in cats. This study also aims to investigate the cardiorespiratory effect of these alternative techniques of induction in dogs and cats. Priming principle (Djaniani & Ribes-Pastor, 1999) consists on the administration of a pre-calculated low dose of an induction agent, administered prior to the following dose administration of the same induction agent until anesthesia is achieved (Kataria et al., 2010). The present study used priming principle with alfaxalone IV to achieve tracheal intubation in dogs and cats premedicated with dexmedetomidine and methadone. As results, the total dose of alfaxalone was significantly reduced by 27% in dogs and 25% in cats. Cardiorespiratory depression was not observed during the study. Co-induction is the concomitant administration of two or more drugs with additive or synergistic effect (Sdrales & Miller, 2013). In humans, this induction technique has been well described using midazolam (Liao et al., 2017). The present study investigated the effective dose (ED₅₀) of midazolam to be used as co-induction with alfaxalone in cats. It was determined that the ED₅₀ of midazolam is 0.08 ± 0.04 mg kg^-1 when co-administered with a low dose of alfaxalone (0.25 mg kg^-1) in premedicated cats with methadone and dexmedetomidine.

Subjects/Keywords: Up-and-down; co-induction; alfaxalone; midazolam; priming; anesthesia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lagos, A. (2018). Alternative Techniques for Alfaxalone Anesthesia Induction in Dogs and Cats. (Masters Thesis). Louisiana State University. Retrieved from https://digitalcommons.lsu.edu/gradschool_theses/4720

Chicago Manual of Style (16^th Edition):

Lagos, Angie. “Alternative Techniques for Alfaxalone Anesthesia Induction in Dogs and Cats.” 2018. Masters Thesis, Louisiana State University. Accessed March 06, 2021. https://digitalcommons.lsu.edu/gradschool_theses/4720.

MLA Handbook (7^th Edition):

Lagos, Angie. “Alternative Techniques for Alfaxalone Anesthesia Induction in Dogs and Cats.” 2018. Web. 06 Mar 2021.

Vancouver:

Lagos A. Alternative Techniques for Alfaxalone Anesthesia Induction in Dogs and Cats. [Internet] [Masters thesis]. Louisiana State University; 2018. [cited 2021 Mar 06]. Available from: https://digitalcommons.lsu.edu/gradschool_theses/4720.

Council of Science Editors:

Lagos A. Alternative Techniques for Alfaxalone Anesthesia Induction in Dogs and Cats. [Masters Thesis]. Louisiana State University; 2018. Available from: https://digitalcommons.lsu.edu/gradschool_theses/4720

University of Guelph

23. Aguilera, Rodrigo. DOSE REDUCTION AND CARDIOPULMONARY EFFECTS OF ANESTHETIC INDUCTION WITH PROPOFOL WITH OR WITHOUT MIDAZOLAM IN CRITICAL CANINE PATIENTS.

Degree: Doctor of Veterinary Science, Department of Clinical Studies, 2019, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/17500

► This thesis describes a prospective, randomized, blinded study to investigate the effects of midazolam as a co-induction drug in combination with propofol, in critically ill… (more)

▼ This thesis describes a prospective, randomized, blinded study to investigate the effects of midazolam as a co-induction drug in combination with propofol, in critically ill dogs. Case enrollment included dogs with a weight ≥ 10 kg and age ranging from 1-15 years, requiring an exploratory laparotomy and classified according to the American Society of Anesthesiologist physical status score (ASA) as III or IV. Dogs were also scored for the Survival Prediction Index (SPI2) to predict their surgical risk. Dogs were allocated to two groups, which included premedication with two separate doses of fentanyl; F1 (2 µg kg-1, IV) and F2 (3 µg kg-1, IV) for instrumentation; then one group was induced with IV propofol, (P: propofol 1 mg kg-1) and the other group with propofol and midazolam (M: propofol 1 mg kg-1, followed by IV midazolam (0.3 mg kg-1), with subsequent propofol (0.25 mg kg-1; q6 seconds) as required to achieve endotracheal intubation. Both groups had anesthesia maintained with isoflurane. Sedation and induction quality was assessed, and dose requirements for induction with propofol were measured and compared between the groups. Selected cardiopulmonary parameters were assessed after F1 and F2, induction, and maintenance with isoflurane with spontaneous and mechanical ventilation during surgical preparation. Measurement times were defined as follows: T0, patients transferred from the intensive care unit (ICU) to anesthesia; T1, 2 minutes after F2; T2, within 5 minutes from induction; T3, patients placed in dorsal recumbency and mechanically ventilated; and T4, surgical preparation. There was no difference in age or weight. Dogs in the M group had a significantly lower propofol induction dose requirement than the P group, associated with similar sedation scores between groups, but a significantly better intubation/induction score in the M group. However, heart rate, arterial blood pressure, respiratory rate, cardiac index, systemic vascular resistance, end-tidal isoflurane concentration and end-tidal carbon dioxide concentration, were similar between groups at all time intervals. The distribution of ASA and SPI2 scores for the dogs was similar in both groups, but there was no correlation between ASA and SPI2 scores. In conclusion, this study demonstrates that co-induction with midazolam improves endotracheal intubation and the induction phase. Despite a reduction in the induction dose of propofol, midazolam co-induction did not improve cardiopulmonary function in critically ill dogs, when compared to a higher dose of propofol alone. Advisors/Committee Members: Sinclair, Melissa (advisor).

Subjects/Keywords: co-induction; propofol; midazolam; cardiac output; critical patients; dogs

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APA (6^th Edition):

Aguilera, R. (2019). DOSE REDUCTION AND CARDIOPULMONARY EFFECTS OF ANESTHETIC INDUCTION WITH PROPOFOL WITH OR WITHOUT MIDAZOLAM IN CRITICAL CANINE PATIENTS. (Doctoral Dissertation). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/17500

Chicago Manual of Style (16^th Edition):

Aguilera, Rodrigo. “DOSE REDUCTION AND CARDIOPULMONARY EFFECTS OF ANESTHETIC INDUCTION WITH PROPOFOL WITH OR WITHOUT MIDAZOLAM IN CRITICAL CANINE PATIENTS.” 2019. Doctoral Dissertation, University of Guelph. Accessed March 06, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/17500.

MLA Handbook (7^th Edition):

Aguilera, Rodrigo. “DOSE REDUCTION AND CARDIOPULMONARY EFFECTS OF ANESTHETIC INDUCTION WITH PROPOFOL WITH OR WITHOUT MIDAZOLAM IN CRITICAL CANINE PATIENTS.” 2019. Web. 06 Mar 2021.

Vancouver:

Aguilera R. DOSE REDUCTION AND CARDIOPULMONARY EFFECTS OF ANESTHETIC INDUCTION WITH PROPOFOL WITH OR WITHOUT MIDAZOLAM IN CRITICAL CANINE PATIENTS. [Internet] [Doctoral dissertation]. University of Guelph; 2019. [cited 2021 Mar 06]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/17500.

Council of Science Editors:

Aguilera R. DOSE REDUCTION AND CARDIOPULMONARY EFFECTS OF ANESTHETIC INDUCTION WITH PROPOFOL WITH OR WITHOUT MIDAZOLAM IN CRITICAL CANINE PATIENTS. [Doctoral Dissertation]. University of Guelph; 2019. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/17500

24. Matsuyama, Tomonori. Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system .

Degree: 2015, Kyoto University

URL: http://hdl.handle.net/2433/202803

Subjects/Keywords: Midazolam; Erythropoietin; Hypoxia-inducible factor

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APA (6^th Edition):

Matsuyama, T. (2015). Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system . (Thesis). Kyoto University. Retrieved from http://hdl.handle.net/2433/202803

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Matsuyama, Tomonori. “Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system .” 2015. Thesis, Kyoto University. Accessed March 06, 2021. http://hdl.handle.net/2433/202803.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Matsuyama, Tomonori. “Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system .” 2015. Web. 06 Mar 2021.

Vancouver:

Matsuyama T. Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system . [Internet] [Thesis]. Kyoto University; 2015. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/2433/202803.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Matsuyama T. Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system . [Thesis]. Kyoto University; 2015. Available from: http://hdl.handle.net/2433/202803

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Sydney

25. Viljoen, André John. Analysis of oxygen saturation levels recorded during dental intravenous sedations - a retrospective quality assurance of 3500 cases .

Degree: 2011, University of Sydney

URL: http://hdl.handle.net/2123/7255

► ABSTRACT Background: The death of a patient under dental intravenous sedation in New South Wales, Australia, in 2002 while being treated by a dentist with… (more)

▼ ABSTRACT Background: The death of a patient under dental intravenous sedation in New South Wales, Australia, in 2002 while being treated by a dentist with appropriate training in intravenous conscious sedation (ICS), (Graduate Diploma in Clinical Dentistry; Conscious Sedation and Pain Control, University of Sydney) has once again brought into question the safety of ICS. The cause of death was irreversible cerebral hypoxia following a cardiac arrest, which was precipitated by numerous periods of ever-deepening hypoxaemia. Aim: This retrospective, quality-assurance audit investigated whether safe oxygen saturation levels could be maintained during single operator/sedationist dental sedations, when operating within the joint Royal Australasian College of Dental Surgeons (RACDS) and Australian and New Zealand College of Anaesthetists (ANZCA) PS21 guidelines for conscious sedation. Methodology: Safe oxygen saturation levels were defined as pulse oximeter readings of 94% and above. The recording of two or more readings of less than 94% during a sedation procedure was defined as the outcome of interest. The association of the variables of age (eighteen and over), gender, weight, the American Society of Anesthesiologists (ASA) Classification I or II and the use of propofol in addition to midazolam and fentanyl, to low saturations, was examined. Two sub-cohorts were randomly generated: 1,750 patients were sedated with iv midazolam and fentanyl and 1,750 patients received propofol, in sub-anaesthetic increments, in addition to midazolam and fentanyl. All patients received supplemental oxygen. Initial sedation was established using midazolam and fentanyl in both sub-cohorts. The second sub-cohort received sub-anaesthetic increments of propofol during times of noxious stimulation. Statistical analysis of the data used cross-tabulation of the variables by outcome, an associated chi- squared test and corresponding logistic regression analysis, together with odds ratio (OR) and a 95% confidence interval (95%CI). Results: Patient exposure to two or more oxygen de-saturations below 94% was uncommon. The null hypothesis could not be rejected because there was no significant difference between the saturation levels recorded for each sub-cohort (μ1 - μ2 = 0), where μ1 was the cohort that received propofol in addition to midazolam and fentanyl, and μ2 was the cohort that received midazolam and fentanyl only. Analysis of the two population groups found them to be quite different in make-up. Had the two population groups been similar in make-up, then μ1 - μ2 may not have equaled 0, and the outcome of the hypothesis test may have been to reject H0. The variables that were significantly associated with low saturations were age, gender and weight. The data showed that males were three times more likely than females to experience low saturations. Patients 45 years and older were nearly eight times more likely to experience low saturations than patients 25 years or younger. Patients classified as being in the gender- specific high weight group…

Subjects/Keywords: safe oxygen saturation levels; midazolam; fentanyl; propofol; intravenous dental sedation

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APA (6^th Edition):

Viljoen, A. J. (2011). Analysis of oxygen saturation levels recorded during dental intravenous sedations - a retrospective quality assurance of 3500 cases . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/7255

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Viljoen, André John. “Analysis of oxygen saturation levels recorded during dental intravenous sedations - a retrospective quality assurance of 3500 cases .” 2011. Thesis, University of Sydney. Accessed March 06, 2021. http://hdl.handle.net/2123/7255.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Viljoen, André John. “Analysis of oxygen saturation levels recorded during dental intravenous sedations - a retrospective quality assurance of 3500 cases .” 2011. Web. 06 Mar 2021.

Vancouver:

Viljoen AJ. Analysis of oxygen saturation levels recorded during dental intravenous sedations - a retrospective quality assurance of 3500 cases . [Internet] [Thesis]. University of Sydney; 2011. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/2123/7255.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Viljoen AJ. Analysis of oxygen saturation levels recorded during dental intravenous sedations - a retrospective quality assurance of 3500 cases . [Thesis]. University of Sydney; 2011. Available from: http://hdl.handle.net/2123/7255

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

26. Wellander, Annika. Smärtsamma procedurer på barn en systematisk litteraturstudie om lustgas kontra midazolam.

Degree: 2016, , Faculty of Health and Society (HS)

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-24429

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Barn kan genomgå smärtsamma procedurer vid sjukhusbesök och tanläkarbesök, vilket innebär en upplevelse av smärta och ångest hos dem. För att hjälpa barn att… (more)

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Barn kan genomgå smärtsamma procedurer vid sjukhusbesök och tanläkarbesök, vilket innebär en upplevelse av smärta och ångest hos dem. För att hjälpa barn att klara av smärtsamma procedurer kan lustgas eller midazolam vara till hjälp. Föreliggande studie syftade till att jämföra effekten av lustgas och midazolam vid användning som premedicinering inför smärtsamma procedurer på barn. Metod: En systematisk litteraturstudie som var byggd på sex randomiserade studier och en observationsstudie. Databaserna Cinahl och PubMed användes för att systematiskt söka efter vetenskapliga artiklar som svarade på frågeställningen. Artiklarna granskades enligt SBU:s mallar. Resultat: De sju studierna tog upp effekter som smärta och oro, sedering och biverkningar i samband med att barn får lustgas eller midazolam vid smärtsamma procedurer. Utifrån resultatet kunde slutsatser dras att ur smärtlindrande/orosdämpande- och sederings-perspektiv var lustgas ett bättre alternativ. Däremot var det ur biverkningssynpunkt tvetydigt vilken premedicinering som bör ges till barn som genomgår smärtsamma procedurer. Jämförelserna mellan studierna blev även problematiska då det användes olika koncentrationer på lustgas och olika mängd och administrationssätt för midazolam inför de smärtsamma procedurerna.

Children can undergo painful procedures during hospital visits, which means an experience of pain and anxiety. To help children cope with painful procedures, nitrous oxide or midazolam may be helpful. This study aims to compare the effect of nitrous oxide and midazolam when used as premedication prior to painful procedures on children. Methods: A systematic literature review based on six randomized trials and one observational study. The databases CINAHL and PubMed was used to systematically search for scientific articles that responded to the question. The articles were reviewed according to the SBU templates. Results: The seven studies addressed effects like pain and anxiety, sedation and side effects when given nitrous oxide or midazolam prior to painful procedures. Based on the results conclusions could be drawn that from analgesic/anxiolytic and sedation point of view nitrous oxide was a better option. However, regarding the side effects, the result were ambiguous as to which premedication should be given to children undergoing painful procedures. The comparisons between the studies also became problematic sinces different concentrations of nitrous oxide and various routes of administration and volume of midazolam were used before the painful procedures.

Subjects/Keywords: Barn; lustgas; midazolam; smärta; Medical and Health Sciences; Medicin och hälsovetenskap

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wellander, A. (2016). Smärtsamma procedurer på barn en systematisk litteraturstudie om lustgas kontra midazolam. (Thesis). , Faculty of Health and Society (HS). Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-24429

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wellander, Annika. “Smärtsamma procedurer på barn en systematisk litteraturstudie om lustgas kontra midazolam.” 2016. Thesis, , Faculty of Health and Society (HS). Accessed March 06, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-24429.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wellander, Annika. “Smärtsamma procedurer på barn en systematisk litteraturstudie om lustgas kontra midazolam.” 2016. Web. 06 Mar 2021.

Vancouver:

Wellander A. Smärtsamma procedurer på barn en systematisk litteraturstudie om lustgas kontra midazolam. [Internet] [Thesis]. , Faculty of Health and Society (HS); 2016. [cited 2021 Mar 06]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-24429.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wellander A. Smärtsamma procedurer på barn en systematisk litteraturstudie om lustgas kontra midazolam. [Thesis]. , Faculty of Health and Society (HS); 2016. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-24429

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

27. Santos, Darklilson Pereira. Controle da ansiedade odontológica: estudo comparativo entre a sedação oral com midazolam e a sedação consciente com a mistura de óxido nitroso e oxigênio em pacientes submetidos à extração de terceiros molares inferiores.

Degree: Mestrado, Cirurgia Buco-Maxilo-Facial, 2012, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/58/58136/tde-10082012-152302/ ;

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O objetivo do trabalho foi avaliar comparativamente o efeito do midazolam 7,5 mg administrado por via oral e da sedação consciente empregando óxido nitroso associado… (more)

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O objetivo do trabalho foi avaliar comparativamente o efeito do midazolam 7,5 mg administrado por via oral e da sedação consciente empregando óxido nitroso associado ao oxigênio a 50% em pacientes submetidos à extração de terceiros molares inferiores na alteração do nível de ansiedade do paciente por meio da dosagem de cortisol salivar, no nível de saturação de oxigênio, na frequência cardíaca e na pressão arterial, na produção de amnésia anterógrada, além de avaliar as Escalas de Ansiedade Dental de Corah (DAS), Escala Visual Análoga para Ansiedade (VAS), Escala Verbal de Ansiedade e Inventário de Spielberger (STAI) na detecção de ansiedade dental. Realizou-se estudo split-mouth, no qual vinte e oito pacientes do gênero masculino foram submetidos à extração de terceiros molares inferiores sob anestesia local e sedação com midazolam e óxido nitroso associado ao oxigênio. Foram obtidos dados objetivos (dosagem de cortisol salivar, saturação de oxigênio, frequência cardíaca e pressão arterial) e subjetivos (Escala de Ansiedade Odontológica de Corah, Inventário de Ansiedade Traço-Estado, Escala Visual Análoga de Ansiedade e Escala Verbal de Ansiedade). Os resultados evidenciaram que os dois métodos de sedação empregados produziram efeitos benéficos e foram seguros na redução da ansiedade pré-operatória sem apresentar efeitos cardiovasculares ou respiratórios siginificantes, e que o midazolam 7,5 mg administrado por via oral foi mais eficaz na redução do cortisol salivar. Considerando as escalas de avaliação de ansiedade empregadas, constatou-se que a Escala de Ansiedade Dental de Corah mostrou ser a mais indicada para se avaliar ansiedade dental.

The study objective was to comparatively assess the effect of midazolam 7.5mg P.O. and conscious sedation with Nitrous oxide associated with oxygen at 50% in patients undergoing lower third molar extractions on the change in the anxiety level of patients by means of salivary cortisol dosage, on oxygen saturation level, on heart rate, on blood pressure, and on production of anterograde amnesia, as well as to assess the Corah\'s Dental Anxiety Scale (DAS), Anxiety Visual Analogue Scale (VAS), Anxiety Verbal Scale and Spilberger State-trait Anxiety Inventory (STAI) for the detection of dental anxiety. It was carried out a split-mouth study, in which twenty-eight male patients underwent lower third molar extraction under local anesthesia and sedation with midazolam and nitrous oxide associated with oxygen. Objective (salivary cortisol dosage, oxygen saturation, heart rate and blood pressure) and subjective (Corah\'s Dental Anxiety Scale, Spilberger State-trait Anxiety Inventory, Anxiety Visual Analogue Scale, and Verbal Anxiety Scale) data have been obtained. The results showed that both sedation methods used produced beneficial effects and were safe in reducing pre-operatory anxiety, showing no significant cardiovascular or respiratory effects, and midazolam 7.5 mg P.O. was more effective in reducing the salivary cortisol. Regarding the anxiety scales employed, it was found…

Advisors/Committee Members: Barros, Valdemar Mallet da Rocha.

Subjects/Keywords: ansiedade dental; Corahs Scale; cortisol salivar; Dental anxiety; escala de Corah; Midazolam; midazolam; Nitrous oxide; óxido nitroso; Salivary Cortisol; terceiro molar; Third molar

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Santos, D. P. (2012). Controle da ansiedade odontológica: estudo comparativo entre a sedação oral com midazolam e a sedação consciente com a mistura de óxido nitroso e oxigênio em pacientes submetidos à extração de terceiros molares inferiores. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/58/58136/tde-10082012-152302/ ;

Chicago Manual of Style (16^th Edition):

Santos, Darklilson Pereira. “Controle da ansiedade odontológica: estudo comparativo entre a sedação oral com midazolam e a sedação consciente com a mistura de óxido nitroso e oxigênio em pacientes submetidos à extração de terceiros molares inferiores.” 2012. Masters Thesis, University of São Paulo. Accessed March 06, 2021. http://www.teses.usp.br/teses/disponiveis/58/58136/tde-10082012-152302/ ;.

MLA Handbook (7^th Edition):

Santos, Darklilson Pereira. “Controle da ansiedade odontológica: estudo comparativo entre a sedação oral com midazolam e a sedação consciente com a mistura de óxido nitroso e oxigênio em pacientes submetidos à extração de terceiros molares inferiores.” 2012. Web. 06 Mar 2021.

Vancouver:

Santos DP. Controle da ansiedade odontológica: estudo comparativo entre a sedação oral com midazolam e a sedação consciente com a mistura de óxido nitroso e oxigênio em pacientes submetidos à extração de terceiros molares inferiores. [Internet] [Masters thesis]. University of São Paulo; 2012. [cited 2021 Mar 06]. Available from: http://www.teses.usp.br/teses/disponiveis/58/58136/tde-10082012-152302/ ;.

Council of Science Editors:

Santos DP. Controle da ansiedade odontológica: estudo comparativo entre a sedação oral com midazolam e a sedação consciente com a mistura de óxido nitroso e oxigênio em pacientes submetidos à extração de terceiros molares inferiores. [Masters Thesis]. University of São Paulo; 2012. Available from: http://www.teses.usp.br/teses/disponiveis/58/58136/tde-10082012-152302/ ;

28. Gregório, Marcelo Gervilla. Validação da polissonografia diurna com sono induzido para o diagnóstico de apnéia obstrutiva do sono.

Degree: PhD, Pneumologia, 2007, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5150/tde-18042007-103524/ ;

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INTRODUÇÃO: A apnéia obstrutiva do sono é uma doença altamente prevalente na população adulta e associada à morbidade significante. A polissonografia noturna é o método… (more)

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INTRODUÇÃO: A apnéia obstrutiva do sono é uma doença altamente prevalente na população adulta e associada à morbidade significante. A polissonografia noturna é o método padrão ouro para o diagnóstico de apnéia obstrutiva do sono. Entretanto seu custo é elevado e a disponibilidade de leitos para polissonografia é muito inferior a demanda. Por esta razão, estratégias para otimizar o diagnóstico de apnéia obstrutiva do sono são urgentes e necessárias. O objetivo deste estudo foi o de comparar um exame diurno de polissonografia, de curta duração e através de sono induzido por benzodiazepínico com a polissonografia noturna para o diagnóstico de apnéia obstrutiva do sono. MÉTODOS: Foram estudamos 40 pacientes divididos em dois grupos baseados no resultado da polissonografia noturna (Índice de Apnéia e Hipopnéia = 15 eventos/hora). Os dezoito Indivíduos portadores de apnéia obstrutiva do sono (id= 46 + 9 anos) e os vinte e dois controles (id= 38 + 10 anos) foram submetidos a uma polissonografia diurna, de curta duração, com indução de sono através de infusão intravenosa lenta de midazolam. RESULTADOS: O sono induzido foi obtido em todos indivíduos. O tempo total de sono foi de 41,5 + 18,9 minutos. A maioria dos eventos respiratórios durante o sono induzido forma obstrutivos e similares aos observados durante a polissonografia noturna. Não houve diferença estatisticamente significativa entre o índice de apnéia e hipopnéia bem como com a saturação mínima de oxigênio obtido pela polissonografia noturna e com sono induzido nos grupos estudados (p>0,05). Reunindo os dois grupos, o índice de apnéia e hipopnéia e a menor saturação de oxigênio obtidos pelos dois métodos tiveram correlação significativa (r=0,67 e r=0,77, respectivamente). A sensibilidade e especificidade para o diagnóstico de apnéia obstrutiva do sono através do sono induzido foi 0,83 e 0,72 respectivamente. Nenhuma complicação foi observada durante o sono induzido. CONCLUSÃO: A polissonografia com sono induzido é um método rápido e seguro que pode ser uma alternativa a polissonografia noturna para o diagnóstico de apnéia obstrutiva do sono.

Polysomnography is the gold standard method for diagnosing obstructive sleep apnea. However, the gap between demand and capacity in performig polysomnography is a major healthcare problem. We sought to compare a short day-time induced sleep with full overnight standard PSG (full PSG) monitoring for the diagnosis of obstructive sleep apnea. We studied 40 patients classified into subjects with obstructive sleep apnea (n=18, age= 46.8 + 9.1yr) and controls (n=22, age= 38.5 + 10,7yr) groups, based on the results of a full polysomnography (apnea-hypopnea index >= 15 events/hour). All subjects underwent a short day-time polysomnography. Sleep was induced by slow intravenous drip infusion of midazolam and achived in all subjects. Total time of induced sleep was 41.5 ± 18.9 min. The majority of the respiratory events during induced sleep were obstructive and similar to that observed during full polysomnography. There was no…

Advisors/Committee Members: Lorenzi Filho, Geraldo.

Subjects/Keywords: Comparative study; Diagnosis/methods; Diagnóstico/métodos; Estudo comparativo; Midazolam; Midazolam; Polissonografia; Polysomnography; Síndromes da apnéia do sono; Sleep; Sleep apnea syndromes; Sono

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gregório, M. G. (2007). Validação da polissonografia diurna com sono induzido para o diagnóstico de apnéia obstrutiva do sono. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5150/tde-18042007-103524/ ;

Chicago Manual of Style (16^th Edition):

Gregório, Marcelo Gervilla. “Validação da polissonografia diurna com sono induzido para o diagnóstico de apnéia obstrutiva do sono.” 2007. Doctoral Dissertation, University of São Paulo. Accessed March 06, 2021. http://www.teses.usp.br/teses/disponiveis/5/5150/tde-18042007-103524/ ;.

MLA Handbook (7^th Edition):

Gregório, Marcelo Gervilla. “Validação da polissonografia diurna com sono induzido para o diagnóstico de apnéia obstrutiva do sono.” 2007. Web. 06 Mar 2021.

Vancouver:

Gregório MG. Validação da polissonografia diurna com sono induzido para o diagnóstico de apnéia obstrutiva do sono. [Internet] [Doctoral dissertation]. University of São Paulo; 2007. [cited 2021 Mar 06]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5150/tde-18042007-103524/ ;.

Council of Science Editors:

Gregório MG. Validação da polissonografia diurna com sono induzido para o diagnóstico de apnéia obstrutiva do sono. [Doctoral Dissertation]. University of São Paulo; 2007. Available from: http://www.teses.usp.br/teses/disponiveis/5/5150/tde-18042007-103524/ ;

29. Tornelli, Mauricio José. Alterações cardiovasculares em cirugias para a colocação de implantes dentários sob anestesia local pré-medicação ansiolítica.

Degree: Mestrado, Clínica Integrada, 2008, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/23/23147/tde-13042009-104123/ ;

►

O Objetivo deste estudo controlado e duplo-cego foi avaliar os efeitos cardiovasculares induzidos pelo bloqueio pterigomandibular com o anestésico local cloridrato de lidocaína 2%, associado… (more)

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O Objetivo deste estudo controlado e duplo-cego foi avaliar os efeitos cardiovasculares induzidos pelo bloqueio pterigomandibular com o anestésico local cloridrato de lidocaína 2%, associado à epinefrina, seguido da administração de ansiolítico (midazolam 15mg) ou placebo, para realização de cirurgia de colocação de implantes dentários inferiores bilaterais, em 22 pacientes (13 mulheres 9 homens). Os parâmetros cardiovasculares Pressão Arterial Sistólica (PAS), Diastólica (PAD), Média (PAM) e Freqüência Cardíaca (FC) foram monitorados pelos métodos oscilométrico e fotopletismográfico. Os valores médios foram registrados a cada minuto e de forma contínua durante as etapas do experimento da seguinte forma: Fase 0 Período basal; Fase 1 Anestesia local; Fase 2 incisão; Fase 3 perfuração; Fase 4 colocação dos implantes; Fase 5 sutura; Fase 6 período final. Os indivíduos que receberam midazolam não apresentaram alterações de PAS, PAD, PAM e FC significativas (p>0,01) comparada ao placebo. Ocorreram alterações significantes dos valores para o grupo que recebeu placebo e dos valores médios do grupo que receberam midazolam na freqüência cardíaca

The purpose of this controlled and double-blind trial was to evaluate cardiovascular effects induced by pterigomandibular block of local anesthetic (LA) 2 % lidocaína hydrochloride with epinephrine, followed administration of benzodiazepine (midazolam 15mg on hour prior) or placebo during the surgical phase of placement of the lower bilateral dental implant in 22 normotensive outpatients (13 female and 9 male). The cardiovascular parameters systolic (SP), diastolic (DP) and mean (MP) pressures and heart rate (HR) were monitored by oscillometric and photopletismographic methods in 06 clinical phases during the procedure. The mean values were recorded every minute and in a continuous way during the phases of the experiment following the sequence: phase 0 basal period; phase 1 - anesthesia local; phase 2 mucoperiostal flap; phase 3 perforation; phase 4 placement of dental implants; phase 5 suture; phase 6 the end period. The group with received midazolam didnt induce significant SP, DP, MP and HR changes (p>0.01) compared to placebo. Significantly higher values in placebo group and mean values in midazolam group in heart-frequency were observed.

Advisors/Committee Members: Rocha, Rodney Garcia.

Subjects/Keywords: Anestésicos Locais; Cardiovascular System; Dentistry; Lidocaína; lidocaine; Local Anesthetics; Midazolam; Odontologia; Sedation; Sistema Cardiovascular

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tornelli, M. J. (2008). Alterações cardiovasculares em cirugias para a colocação de implantes dentários sob anestesia local pré-medicação ansiolítica. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/23/23147/tde-13042009-104123/ ;

Chicago Manual of Style (16^th Edition):

Tornelli, Mauricio José. “Alterações cardiovasculares em cirugias para a colocação de implantes dentários sob anestesia local pré-medicação ansiolítica.” 2008. Masters Thesis, University of São Paulo. Accessed March 06, 2021. http://www.teses.usp.br/teses/disponiveis/23/23147/tde-13042009-104123/ ;.

MLA Handbook (7^th Edition):

Tornelli, Mauricio José. “Alterações cardiovasculares em cirugias para a colocação de implantes dentários sob anestesia local pré-medicação ansiolítica.” 2008. Web. 06 Mar 2021.

Vancouver:

Tornelli MJ. Alterações cardiovasculares em cirugias para a colocação de implantes dentários sob anestesia local pré-medicação ansiolítica. [Internet] [Masters thesis]. University of São Paulo; 2008. [cited 2021 Mar 06]. Available from: http://www.teses.usp.br/teses/disponiveis/23/23147/tde-13042009-104123/ ;.

Council of Science Editors:

Tornelli MJ. Alterações cardiovasculares em cirugias para a colocação de implantes dentários sob anestesia local pré-medicação ansiolítica. [Masters Thesis]. University of São Paulo; 2008. Available from: http://www.teses.usp.br/teses/disponiveis/23/23147/tde-13042009-104123/ ;

University of Alberta

30. El Sayed, Dalia. The effects of hyperlipidemia on the pharmacokinetic and pharmacodynamic aspects of amiodarone and ketoconazole.

Degree: PhD, Faculty of Pharmacy and Pharmaceutical Sciences, 2010, University of Alberta

URL: https://era.library.ualberta.ca/files/w0892b67r

► The influence of hyperlipidemia on the pharmacodynamic and pharmacokinetic aspects of lipophilic drugs was explored. The antiarrhythmic, amiodarone, and the antifungal, (±)-ketoconazole, were used as… (more)

▼ The influence of hyperlipidemia on the pharmacodynamic and pharmacokinetic aspects of lipophilic drugs was explored. The antiarrhythmic, amiodarone, and the antifungal, (±)-ketoconazole, were used as model drugs. Experimental hyperlipidemia was induced in rat using poloxamer 407 and two sensitive novel HPLC assays were developed. In a multiple dosing study, hyperlipidemia increased amiodarone plasma concentrations, heart concentrations and electrocardiographic changes. The amiodarone heart uptake could not be totally attributed to its unbound fraction, where the cardiac very low density lipoprotein receptors seemed to play a role in the uptake of bound drug. Amiodarone liver metabolism in presence and absence of hyperlipidemia was studied using isolated primary rat liver hepatocytes. The metabolism of amiodarone was lower in hepatocytes isolated from hyperlipidemic than those from normolipidemic rats. Hyperlipidemic serum resulted in a decrease in amiodarone metabolism and when coincubated, the expected decrease in unbound fraction seemed to resulted in greater inhibition of metabolism. (±)-Ketoconazole showed stereoselectivity in its pharmacokinetics in rat with (+)-ketoconazole showing higher plasma concentrations than its antipode. This was attributed to its higher protein binding. There was no difference in the total bioavailability of the two enantiomers. Ketoconazole enantiomers exhibited nonlinear pharmacokinetics. In normolipidemic rat plasma ketoconazole enantiomers were more than 95% bound to lipoprotein deficient fraction. Hyperlipidemia resulted in shifting both enantiomers 20% to very low density and low density lipoprotein fractions. In a pharmacokinetic assessment, hyperlipidemia was found to increase ketoconazole enantiomer volume of distribution. Moreover, the stereoselectivity ratios of most pharmacokinetic parameters were changed. After oral dosing, the uptake of (-)-ketoconazole was significantly decreased. Since ketoconazole is used as a potent CYP3A inhibitor, alteration in liver concentrations of (-)-ketoconazole, the more potent inhibitory enantiomer, could decrease its CYP inhibitory potential. Hyperlipidemia potentiated the CYP-mediated interaction between ketoconazole and midazolam with significantly higher midazolam AUC and lower clearance. This was attributed to the inhibitory action of ketoconazole and the effect of hyperlipidemia on the binding of midazolam. Hyperlipidemia was found to unexpectedly decrease midazolam unbound fraction in plasma. In conclusion, the findings could explain some unexpected dose versus effect outcomes in hyperlipidemic patients receiving amiodarone or ketoconazole.

Subjects/Keywords: Drug metabolism; Pharmacokinetics; Hyperlipidemia; Ketoconazole; hepatocyte; Pharmacodynamics; Midazolam; Amiodarone; Protein binding; Stereoselectivity; ECG; HPLC

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APA (6^th Edition):

El Sayed, D. (2010). The effects of hyperlipidemia on the pharmacokinetic and pharmacodynamic aspects of amiodarone and ketoconazole. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/w0892b67r

Chicago Manual of Style (16^th Edition):

El Sayed, Dalia. “The effects of hyperlipidemia on the pharmacokinetic and pharmacodynamic aspects of amiodarone and ketoconazole.” 2010. Doctoral Dissertation, University of Alberta. Accessed March 06, 2021. https://era.library.ualberta.ca/files/w0892b67r.

MLA Handbook (7^th Edition):

El Sayed, Dalia. “The effects of hyperlipidemia on the pharmacokinetic and pharmacodynamic aspects of amiodarone and ketoconazole.” 2010. Web. 06 Mar 2021.

Vancouver:

El Sayed D. The effects of hyperlipidemia on the pharmacokinetic and pharmacodynamic aspects of amiodarone and ketoconazole. [Internet] [Doctoral dissertation]. University of Alberta; 2010. [cited 2021 Mar 06]. Available from: https://era.library.ualberta.ca/files/w0892b67r.

Council of Science Editors:

El Sayed D. The effects of hyperlipidemia on the pharmacokinetic and pharmacodynamic aspects of amiodarone and ketoconazole. [Doctoral Dissertation]. University of Alberta; 2010. Available from: https://era.library.ualberta.ca/files/w0892b67r

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