subject:(Micromixing)

UCLA

1. Folk, Christopher. Optimized Mixing in Microchannels with Integrated Microactuators.

Degree: Aerospace Engineering, 2014, UCLA

URL: http://www.escholarship.org/uc/item/33c1h254

► Microscale valves and pumps have been designed and fabricated for integration into a microfluidic circuit. Furthermore, a micromixer for this circuit has been designed and… (more)

Subjects/Keywords: Aerospace engineering; MEMS; microfluidics; micromixing

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APA (6^th Edition):

Folk, C. (2014). Optimized Mixing in Microchannels with Integrated Microactuators. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/33c1h254

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Folk, Christopher. “Optimized Mixing in Microchannels with Integrated Microactuators.” 2014. Thesis, UCLA. Accessed February 27, 2021. http://www.escholarship.org/uc/item/33c1h254.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Folk, Christopher. “Optimized Mixing in Microchannels with Integrated Microactuators.” 2014. Web. 27 Feb 2021.

Vancouver:

Folk C. Optimized Mixing in Microchannels with Integrated Microactuators. [Internet] [Thesis]. UCLA; 2014. [cited 2021 Feb 27]. Available from: http://www.escholarship.org/uc/item/33c1h254.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Folk C. Optimized Mixing in Microchannels with Integrated Microactuators. [Thesis]. UCLA; 2014. Available from: http://www.escholarship.org/uc/item/33c1h254

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

2. Sudarsan, Arjun Penubolu. Multivortex micromixing: novel techniques using Dean flows for passive microfluidic mixing.

Degree: PhD, Chemical Engineering, 2007, Texas A&M University

URL: http://hdl.handle.net/1969.1/4686

► Mixing of fluids at the microscale poses a variety of challenges, many of which arise from the fact that molecular diffusion is the dominant transport… (more)

Subjects/Keywords: microfluidics; micromixing

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APA (6^th Edition):

Sudarsan, A. P. (2007). Multivortex micromixing: novel techniques using Dean flows for passive microfluidic mixing. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/4686

Chicago Manual of Style (16^th Edition):

Sudarsan, Arjun Penubolu. “Multivortex micromixing: novel techniques using Dean flows for passive microfluidic mixing.” 2007. Doctoral Dissertation, Texas A&M University. Accessed February 27, 2021. http://hdl.handle.net/1969.1/4686.

MLA Handbook (7^th Edition):

Sudarsan, Arjun Penubolu. “Multivortex micromixing: novel techniques using Dean flows for passive microfluidic mixing.” 2007. Web. 27 Feb 2021.

Vancouver:

Sudarsan AP. Multivortex micromixing: novel techniques using Dean flows for passive microfluidic mixing. [Internet] [Doctoral dissertation]. Texas A&M University; 2007. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/1969.1/4686.

Council of Science Editors:

Sudarsan AP. Multivortex micromixing: novel techniques using Dean flows for passive microfluidic mixing. [Doctoral Dissertation]. Texas A&M University; 2007. Available from: http://hdl.handle.net/1969.1/4686

Universidade Nova

3. Bernacka-Wojcik, Iwona. Design and development of a microfluidic platform for use with colorimetric gold nanoprobe assays.

Degree: 2014, Universidade Nova

URL: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/13599

►

Due to the importance and wide applications of the DNA analysis, there is a need to make genetic analysis more available and more affordable. As… (more)

▼

Due to the importance and wide applications of the DNA analysis, there is a need to make genetic analysis more available and more affordable. As such, the aim of this PhD thesis is to optimize a colorimetric DNA biosensor based on gold nanoprobes developed in CEMOP by reducing its price and the needed volume of solution without compromising the device sensitivity and reliability, towards the point of care use. Firstly, the price of the biosensor was decreased by replacing the silicon photodetector by a low cost, solution processed TiO2 photodetector. To further reduce the photodetector price, a novel fabrication method was developed: a cost-effective inkjet printing technology that enabled to increase TiO2 surface area. Secondly, the DNA biosensor was optimized by means of microfluidics that offer advantages of miniaturization, much lower sample/reagents consumption, enhanced system performance and functionality by integrating different components. In the developed microfluidic platform, the optical path length was extended by detecting along the channel and the light was transmitted by optical fibres enabling to guide the light very close to the analysed solution. Microfluidic chip of high aspect ratio (~13), smooth and nearly vertical sidewalls was fabricated in PDMS using a SU-8 mould for patterning. The platform coupled to the gold nanoprobe assay enabled detection of Mycobacterium tuberculosis using 3 8l on DNA solution, i.e. 20 times less than in the previous state-of-the-art. Subsequently, the bio-microfluidic platform was optimized in terms of cost, electrical signal processing and sensitivity to colour variation, yielding 160% improvement of colorimetric AuNPs analysis. Planar microlenses were incorporated to converge light into the sample and then to the output fibre core increasing 6 times the signal-to-losses ratio. The optimized platform enabled detection of single nucleotide polymorphism related with obesity risk (FTO) using target DNA concentration below the limit of detection of the conventionally used microplate reader (i.e. 15 ng/μl) with 10 times lower solution volume (3 μl). The combination of the unique optical properties of gold nanoprobes with microfluidic platform resulted in sensitive and accurate sensor for single nucleotide polymorphism detection operating using small volumes of solutions and without the need for substrate functionalization or sophisticated instrumentation. Simultaneously, to enable on chip reagents mixing, a PDMS micromixer was developed and optimized for the highest efficiency, low pressure drop and short mixing length. The optimized device shows 80% of mixing efficiency at Re = 0.1 in 2.5 mm long mixer with the pressure drop of 6 Pa, satisfying requirements for the application in the microfluidic platform for DNA analysis.

Portuguese Science Foundation - (SFRH/BD/44258/2008), “SMART-EC” project

Advisors/Committee Members: Martins, Rodrigo, Baptista, Pedro, Águas, Hugo.

Subjects/Keywords: Microfluidos; Biosensor de ADN; PDMS; SU-8; Fibras ópticas; Micromixing

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APA (6^th Edition):

Bernacka-Wojcik, I. (2014). Design and development of a microfluidic platform for use with colorimetric gold nanoprobe assays. (Thesis). Universidade Nova. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/13599

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bernacka-Wojcik, Iwona. “Design and development of a microfluidic platform for use with colorimetric gold nanoprobe assays.” 2014. Thesis, Universidade Nova. Accessed February 27, 2021. http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/13599.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bernacka-Wojcik, Iwona. “Design and development of a microfluidic platform for use with colorimetric gold nanoprobe assays.” 2014. Web. 27 Feb 2021.

Vancouver:

Bernacka-Wojcik I. Design and development of a microfluidic platform for use with colorimetric gold nanoprobe assays. [Internet] [Thesis]. Universidade Nova; 2014. [cited 2021 Feb 27]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/13599.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bernacka-Wojcik I. Design and development of a microfluidic platform for use with colorimetric gold nanoprobe assays. [Thesis]. Universidade Nova; 2014. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/13599

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Colorado State University

4. Himstedt, Heath Henry. Novel fouling resistant magnetically-responsive membranes for treatment of impaired water.

Degree: PhD, Chemical and Biological Engineering, 2012, Colorado State University

URL: http://hdl.handle.net/10217/71667

► The focus of this dissertation research is the development of novel fouling resistant magnetically-responsive micromixing filtration membranes. Maintenance and replacement costs account for well over… (more)

▼ The focus of this dissertation research is the development of novel fouling resistant magnetically-responsive micromixing filtration membranes. Maintenance and replacement costs account for well over half the total cost of membrane processes. Fouling limits membrane performance by reducing membrane flux and lifetime. Specialized stimuli-responsive membranes have been investigated as a means to combat fouling; however, stimuli such as pH, solution ionic strength, and temperature require changes to the entire feedstream to impart a response. This is time consuming and expensive. The novel membranes presented in this dissertation combat fouling through active hydrodynamic disruption of the filtration boundary layer via instant activation by an external magnetic field without the need to adjust feedstream conditions. The fouling resistant properties of these membranes were tested by using them to treat oily wastewaters from oil and gas production, known as produced water. Chapter 1 introduces concepts referenced throughout the dissertation narrative including basic principles of pressure-driven membrane technology; the principles of membrane fouling and fouling resistant membranes; a review of applications of (super)paramagnetic nanoparticles; and a discussion of produced water and the treatment challenges it presents. Chapters 2 through 6 are published, or soon to be submitted, scientific papers which chronicle the development and application of these novel membranes. Chapter 2 discusses the concepts behind magnetically-activated micromixing and presents initial proof-of-concept nanofiltraiton membranes. Chapter 3 employs track-etched membranes to characterize the modification protocol and the magnitude of the magnetic response, as well as the relationship between the two. Chapter 4 determines the effect of modification grafting density on mixing efficacy and membrane filtration properties. Chapter 5 shows the improvements to membrane performance and lifetime attributable to magnetically-activated mixing during filtration of model produced water and realistic produced water. Chapter 6 builds upon Chapter 5 by using treated realistic produced water permeate as irrigation water. Chapters 7 and 8 summarize the research findings and present possible direction for future research, respectively. This work presents the development and one potential application of novel magnetically-activated micromixing membranes. These membranes reduce membrane fouling by inducing hydrodynamic mixing in an alternating magnetic field. These membranes could lead to improved membrane performance and lifetime when treating highly fouling feedstreams. This would significantly decrease membrane maintenance and replacement costs and could lead to new clean water product streams. Advisors/Committee Members: Wickramasinghe, S. Ranil (advisor), Bailey, Travis (committee member), Qian, Xianghong (committee member), Ulbricht, Mathias (committee member), Waskom, Reagan (committee member).

Subjects/Keywords: impaired water; water treatment; responsive membranes; magnetic response; micromixing; fouling resistant

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APA (6^th Edition):

Himstedt, H. H. (2012). Novel fouling resistant magnetically-responsive membranes for treatment of impaired water. (Doctoral Dissertation). Colorado State University. Retrieved from http://hdl.handle.net/10217/71667

Chicago Manual of Style (16^th Edition):

Himstedt, Heath Henry. “Novel fouling resistant magnetically-responsive membranes for treatment of impaired water.” 2012. Doctoral Dissertation, Colorado State University. Accessed February 27, 2021. http://hdl.handle.net/10217/71667.

MLA Handbook (7^th Edition):

Himstedt, Heath Henry. “Novel fouling resistant magnetically-responsive membranes for treatment of impaired water.” 2012. Web. 27 Feb 2021.

Vancouver:

Himstedt HH. Novel fouling resistant magnetically-responsive membranes for treatment of impaired water. [Internet] [Doctoral dissertation]. Colorado State University; 2012. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10217/71667.

Council of Science Editors:

Himstedt HH. Novel fouling resistant magnetically-responsive membranes for treatment of impaired water. [Doctoral Dissertation]. Colorado State University; 2012. Available from: http://hdl.handle.net/10217/71667

5. LAKSHMI BALASUBRAMANIAM. COMPAPRATIVE STUDY OF CURVATURE INDUCED IMPROVEMENT IN MASS TRANSFER AND FOULING.

Degree: 2016, National University of Singapore

URL: http://scholarbank.nus.edu.sg/handle/10635/134554

Subjects/Keywords: Micromixing; Dean vortices; Microchannel fouling

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APA (6^th Edition):

BALASUBRAMANIAM, L. (2016). COMPAPRATIVE STUDY OF CURVATURE INDUCED IMPROVEMENT IN MASS TRANSFER AND FOULING. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/134554

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

BALASUBRAMANIAM, LAKSHMI. “COMPAPRATIVE STUDY OF CURVATURE INDUCED IMPROVEMENT IN MASS TRANSFER AND FOULING.” 2016. Thesis, National University of Singapore. Accessed February 27, 2021. http://scholarbank.nus.edu.sg/handle/10635/134554.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

BALASUBRAMANIAM, LAKSHMI. “COMPAPRATIVE STUDY OF CURVATURE INDUCED IMPROVEMENT IN MASS TRANSFER AND FOULING.” 2016. Web. 27 Feb 2021.

Vancouver:

BALASUBRAMANIAM L. COMPAPRATIVE STUDY OF CURVATURE INDUCED IMPROVEMENT IN MASS TRANSFER AND FOULING. [Internet] [Thesis]. National University of Singapore; 2016. [cited 2021 Feb 27]. Available from: http://scholarbank.nus.edu.sg/handle/10635/134554.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

BALASUBRAMANIAM L. COMPAPRATIVE STUDY OF CURVATURE INDUCED IMPROVEMENT IN MASS TRANSFER AND FOULING. [Thesis]. National University of Singapore; 2016. Available from: http://scholarbank.nus.edu.sg/handle/10635/134554

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Penn State University

6. Orbay, Sinem. Acoustically Driven Micro Electro-Mechanical Mixers for Biomedical Applications.

Degree: 2016, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/9306sz28s

► Microelectromechanical systems (MEMS) have become enabling technologies on many research areas. In this dissertation, we present the use of acoustofluidic MEMS for bioengineering applications. Firstly,… (more)

Subjects/Keywords: Micromixing; high-viscosity fluid; acoustofluidics; polyethylene glycol (PEG); High viscosity fluids; Acoustofluidics; Artificial cilia

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APA (6^th Edition):

Orbay, S. (2016). Acoustically Driven Micro Electro-Mechanical Mixers for Biomedical Applications. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/9306sz28s

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Orbay, Sinem. “Acoustically Driven Micro Electro-Mechanical Mixers for Biomedical Applications.” 2016. Thesis, Penn State University. Accessed February 27, 2021. https://submit-etda.libraries.psu.edu/catalog/9306sz28s.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Orbay, Sinem. “Acoustically Driven Micro Electro-Mechanical Mixers for Biomedical Applications.” 2016. Web. 27 Feb 2021.

Vancouver:

Orbay S. Acoustically Driven Micro Electro-Mechanical Mixers for Biomedical Applications. [Internet] [Thesis]. Penn State University; 2016. [cited 2021 Feb 27]. Available from: https://submit-etda.libraries.psu.edu/catalog/9306sz28s.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Orbay S. Acoustically Driven Micro Electro-Mechanical Mixers for Biomedical Applications. [Thesis]. Penn State University; 2016. Available from: https://submit-etda.libraries.psu.edu/catalog/9306sz28s

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Urbana-Champaign

7. Rallabandi, Venkatarama Bhargav. Quantifying microbubble streaming and its applications.

Degree: PhD, Theoretical & Applied Mechans, 2015, University of Illinois – Urbana-Champaign

URL: http://hdl.handle.net/2142/88198

► The growing interest in microfluidics in the last two decades has resulted in new and exciting ways in which to drive microfluidic flows. A simple… (more)

▼ The growing interest in microfluidics in the last two decades has resulted in new and exciting ways in which to drive microfluidic flows. A simple and powerful flow actuation method involves the use of acoustically excited microbubbles. For ease of manufacture and flow control, setups have largely focused on microbubbles of semi-cylindrical shape, attached to a wall of the microchannel. The application of an ultrasound field drives oscillations of the bubble interface, which then become rectified into strong secondary steady currents in the fluid, termed ``streaming''. While several researchers have used such setups in experiments, a theoretical quantification of the bubble streaming flows, crucial for the systematic design of practical microfluidics applications, has lagged behind. In the first part of the dissertation, we resolve both the primary oscillatory and secondary steady flow components. We begin by developing an asymptotic theory describing the oscillatory response of the bubble to the applied acoustic field. We show that the presence of viscous boundary layers and pinned contact lines at the walls (i) strongly couples volume oscillations of the bubble to shape oscillations of the interface, and (ii) results in much wider surface-mode frequency resonance peaks than is nominally predicted by potential flow theory. The oscillatory dynamics then feed into a calculation of the secondary flow, which rigorously accounts for boundary layers over the bubble and the wall. We show that the two-dimensional steady vortical streaming flows observed in experiment are governed at low frequencies by surface mode dynamics, but undergo a reversal of orientation at higher frequencies, where volume oscillations dominate. The theory therefore connects the oscillatory dynamics to the steady streaming, reproducing the entire spectrum of steady flow patterns observed in experiments, with no adjustable parameters. The 2D theory is then modified to include 3D flow effects, in the light of recent collaborative experimental measurements. We show that these flows arise due to the axial confinement of the bubble by no-slip walls, and can be modeled by a perturbation of the 2D streaming solutions by additional (axial) Stokes solutions. The 3D theory explains the experimentally observed flow kinematics over a wide range of time scales, showing that the 2D trajectories typically observed in experiments are in fact sections of a higher three-dimensional flow structure that becomes apparent only on much longer time scales. We then develop a Hamiltonian formalism that governs the long time 3D motion and is applicable to any perturbed 2D flow under confinement. Having now systematically developed a theoretical description of the flow field, the second part of the dissertation deals with its application to practically useful situations in microfluidics. We first analyze the micromixing between two fluid streams continuously transported through the channel by a Poiseuille flow, whose mixing properties are enhanced by an array of… Advisors/Committee Members: Hilgenfeldt, Sascha (advisor), Hilgenfeldt, Sascha (Committee Chair), Freund, Jonathan B. (committee member), Ewoldt, Randy H. (committee member), Bodony, Daniel J. (committee member).

Subjects/Keywords: Microfluidics; Acoustics; Microbubbles; Streaming; Bubble dynamics; Micromixing; Boundary layers; Low-Reynolds-number hydrodynamics

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APA (6^th Edition):

Rallabandi, V. B. (2015). Quantifying microbubble streaming and its applications. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/88198

Chicago Manual of Style (16^th Edition):

Rallabandi, Venkatarama Bhargav. “Quantifying microbubble streaming and its applications.” 2015. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed February 27, 2021. http://hdl.handle.net/2142/88198.

MLA Handbook (7^th Edition):

Rallabandi, Venkatarama Bhargav. “Quantifying microbubble streaming and its applications.” 2015. Web. 27 Feb 2021.

Vancouver:

Rallabandi VB. Quantifying microbubble streaming and its applications. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2015. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2142/88198.

Council of Science Editors:

Rallabandi VB. Quantifying microbubble streaming and its applications. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2015. Available from: http://hdl.handle.net/2142/88198

INP Toulouse

8. Ávila López, Marco Antonio. Energy dissipation and mixing characterization in continuous oscillatory baffled reactor : Dissipation d'énergie et caractérisation du mélange dans des réacteurs continus oscillatoire.

Degree: Docteur es, Genie des Procédés et de l'Environnement, 2020, INP Toulouse

URL: http://www.theses.fr/2020INPT0060

►

Cette thèse de doctorat vise à étudier le micro et macromélange dans un réacteur continu à flux oscillatoire (COBR) lors de l’injection d'un composé secondaire… (more)

▼

Cette thèse de doctorat vise à étudier le micro et macromélange dans un réacteur continu à flux oscillatoire (COBR) lors de l’injection d'un composé secondaire dans l’écoulement principal. L'effet de la position de l’alimentation secondaire, l'influence des conditions oscillatoires et de la puissance dissipée sur les performances de macro et de micromélange sont analysés à l'aide de simulations numériques et d'expériences réalisées dans un réacteur commercial OBR Nitech® avec des constrictions lisses. La dissipation d'énergie est calculée par simulation numérique (CFD) en utilisant deux méthodes différentes - via la dissipation d'énergie visqueuse et par bilan de l’énergie mécanique, cette dernière étant préférée car elle est moins exigeante en terme de nombre de mailles. Un nouveau nombre adimensionnel caractérisant la puissance dissipée est proposé, outil spécifique de prédiction de la puissance dissipée dans les COBRs et indispensable pour l’extrapolation. L’analyse de la qualité spatiale du mélange a montré que, pour une position de la source d’injection correctement choisie, les performances du mélange s’améliorent considérablement en passant de 2% à 87% par rapport au système parfaitement mélangé lorsque le rapport des débits oscillatoire et net augmente. L'influence des conditions oscillatoires et du débit de l’alimentation secondaire sur la qualité du micromélange est analysée. Des amplitudes élevées et des fréquences basses sont préférables aux amplitudes basses et aux fréquences élevées et conduisent à une meilleure performance de micromélange.

The focus of this thesis is to study the macro and micromixing performance of a secondary component in the bulk flow and how it should be introduced into a COBR. The effect of the position of secondary feeds, the influence of the oscillatory conditions and power dissipation on the macro and micromixing performance is studied, using numerical simulations and experiments carried out in a commercial Nitech® OBR with smooth constrictions. Energy dissipation is calculated through CFD simulations using two different ways – via viscous energy dissipation and the mechanical energy balance, the latter being preferred due to its lower demand for a refined computational mesh. A dimensionless power density number is obtained and proposed as a useful tool in the prediction of power density in COBRs. The impact of the position where a secondary feed enters the COBR on the spatial mixing quality is studied, and shows that when the source position is chosen correctly, an increase in the velocity ratio enhances mixing performance from 2% to 87% of the perfectly mixed state. The influence of the oscillatory conditions and flow rate of a secondary feed on the micromixing quality is analysed. Micromixing performance does not appear to correlate directly with power density. However, higher amplitudes and lower frequencies are preferred over lower amplitudes and higher frequencies to have a better micromixing performance. An attempt at characterising macromixing in the COBR…

Advisors/Committee Members: Poux, Martine (thesis director), Aubin, Joelle (thesis director).

Subjects/Keywords: COBR; Dissipation énergétique; Macromélange; Micromélange; CFD; COBR; Energy dissipation rate; Macromixing; Micromixing; CFD; 660

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APA (6^th Edition):

Ávila López, M. A. (2020). Energy dissipation and mixing characterization in continuous oscillatory baffled reactor : Dissipation d'énergie et caractérisation du mélange dans des réacteurs continus oscillatoire. (Doctoral Dissertation). INP Toulouse. Retrieved from http://www.theses.fr/2020INPT0060

Chicago Manual of Style (16^th Edition):

Ávila López, Marco Antonio. “Energy dissipation and mixing characterization in continuous oscillatory baffled reactor : Dissipation d'énergie et caractérisation du mélange dans des réacteurs continus oscillatoire.” 2020. Doctoral Dissertation, INP Toulouse. Accessed February 27, 2021. http://www.theses.fr/2020INPT0060.

MLA Handbook (7^th Edition):

Ávila López, Marco Antonio. “Energy dissipation and mixing characterization in continuous oscillatory baffled reactor : Dissipation d'énergie et caractérisation du mélange dans des réacteurs continus oscillatoire.” 2020. Web. 27 Feb 2021.

Vancouver:

Ávila López MA. Energy dissipation and mixing characterization in continuous oscillatory baffled reactor : Dissipation d'énergie et caractérisation du mélange dans des réacteurs continus oscillatoire. [Internet] [Doctoral dissertation]. INP Toulouse; 2020. [cited 2021 Feb 27]. Available from: http://www.theses.fr/2020INPT0060.

Council of Science Editors:

Ávila López MA. Energy dissipation and mixing characterization in continuous oscillatory baffled reactor : Dissipation d'énergie et caractérisation du mélange dans des réacteurs continus oscillatoire. [Doctoral Dissertation]. INP Toulouse; 2020. Available from: http://www.theses.fr/2020INPT0060

University of Alberta

9. Shah, Syed Imran A. The Effects of Mixing, Reaction Rate and Stoichiometry on Yield for Mixing Sensitive Reactions.

Degree: MS, Department of Chemical & Materials Engineering and Department of Mechanical Engineering, 2010, University of Alberta

URL: https://era.library.ualberta.ca/files/zw12z611q

► Competitive-Consecutive and Competitive-Parallel reactions are both mixing sensitive reactions; the yield of desired product from these reactions depends on how fast the reactants are brought… (more)

Subjects/Keywords: Mixing; Yield; Micromixing; Competitive Parallel; Reaction Diffusion equation; Mixing sensitive reaction; Damkohler Number; Competitive Consecutive; Stoichiometry

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APA (6^th Edition):

Shah, S. I. A. (2010). The Effects of Mixing, Reaction Rate and Stoichiometry on Yield for Mixing Sensitive Reactions. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/zw12z611q

Chicago Manual of Style (16^th Edition):

Shah, Syed Imran A. “The Effects of Mixing, Reaction Rate and Stoichiometry on Yield for Mixing Sensitive Reactions.” 2010. Masters Thesis, University of Alberta. Accessed February 27, 2021. https://era.library.ualberta.ca/files/zw12z611q.

MLA Handbook (7^th Edition):

Shah, Syed Imran A. “The Effects of Mixing, Reaction Rate and Stoichiometry on Yield for Mixing Sensitive Reactions.” 2010. Web. 27 Feb 2021.

Vancouver:

Shah SIA. The Effects of Mixing, Reaction Rate and Stoichiometry on Yield for Mixing Sensitive Reactions. [Internet] [Masters thesis]. University of Alberta; 2010. [cited 2021 Feb 27]. Available from: https://era.library.ualberta.ca/files/zw12z611q.

Council of Science Editors:

Shah SIA. The Effects of Mixing, Reaction Rate and Stoichiometry on Yield for Mixing Sensitive Reactions. [Masters Thesis]. University of Alberta; 2010. Available from: https://era.library.ualberta.ca/files/zw12z611q

McMaster University

10. Kazemi, Amir Sadegh. Development of stirred well filtration as a high-throughput technique for downstream bioprocessing.

Degree: MASc, 2014, McMaster University

URL: http://hdl.handle.net/11375/16153

►

Micro-scale processing (MSP) techniques are miniaturized version of upstream and downstream conventional unit operations that are designed to accelerate the pace of bioprocess design and… (more)

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Micro-scale processing (MSP) techniques are miniaturized version of upstream and downstream conventional unit operations that are designed to accelerate the pace of bioprocess design and development. Previous ‘dead end’ filtration studies have demonstrated the usefulness of this concept for membrane filtration processes. However, these experiments were performed without stirring which is the most common strategy to control the effects of concentration polarization and fouling on filtration performance. In this work, the pressure-driven stirred conditions of a conventional stirred-cell module were integrated with a 96-well filter plate to develop a high throughput technique called ‘stirred-well filtration’ (SWF). The design allowed for up to eight constant flux filtration experiments to be conducted at once using a multi-rack programmable syringe pump and a magnetic lateral tumble stirrer. An array of pressure transducers was used to monitor the transmembrane pressure (TMP) in each well. The protein sieving behavior and fouling propensity of Omega™ ultrafiltration membranes were assessed via a combination of hydraulic permeability measurements and protein sieving tests in constant filtrate flux mode. The TMP profile during filtration of bovine serum albumin (BSA) solution was strongly dependent on the stirring conditions – for example the maximum TMP in the stirred wells were an average of 7.5, 3.8, and 2.6 times lower than those in the unstirred wells at filtrate fluxes of 12, 36, and 60 LMH (5, 15, and 25 μL/min) respectively. The consistency of the data across different wells for the same stirring condition was very good. To demonstrate the effectiveness of the SWF technique, the eight tests for a simple 2² factorial design-of-experiments (DOE) test with duplicates was run to evaluate the effect of solution pH and salt concentration on protein filtration. The combination of SWF with statistical methods such as DOE is shown to be an effective strategy for high-throughput optimization of membrane filtration processes.

Dissertation

Master of Applied Science (MASc)

Advisors/Committee Members: Latulippe, David, Chemical Engineering.

Subjects/Keywords: Microscale processing; High-throughput testing; Downstream bioprocessing; Stirred well filtration (SWF); BSA filtration; Micromixing; Fouling test; Omega™ membrane

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kazemi, A. S. (2014). Development of stirred well filtration as a high-throughput technique for downstream bioprocessing. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/16153

Chicago Manual of Style (16^th Edition):

Kazemi, Amir Sadegh. “Development of stirred well filtration as a high-throughput technique for downstream bioprocessing.” 2014. Masters Thesis, McMaster University. Accessed February 27, 2021. http://hdl.handle.net/11375/16153.

MLA Handbook (7^th Edition):

Kazemi, Amir Sadegh. “Development of stirred well filtration as a high-throughput technique for downstream bioprocessing.” 2014. Web. 27 Feb 2021.

Vancouver:

Kazemi AS. Development of stirred well filtration as a high-throughput technique for downstream bioprocessing. [Internet] [Masters thesis]. McMaster University; 2014. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/11375/16153.

Council of Science Editors:

Kazemi AS. Development of stirred well filtration as a high-throughput technique for downstream bioprocessing. [Masters Thesis]. McMaster University; 2014. Available from: http://hdl.handle.net/11375/16153

11. Lafficher, Robin. Nouveau procédé de précipitation pour la synthèse d’alumine : New precipitation process for alumina synthesis.

Degree: Docteur es, Génie des procédés, 2016, Lyon

URL: http://www.theses.fr/2016LYSE1248

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Le contrôle de la porosité des supports de catalyseurs est un enjeu important dans l'industrie du raffinage. L'objectif de cette thèse est de développer un… (more)

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Le contrôle de la porosité des supports de catalyseurs est un enjeu important dans l'industrie du raffinage. L'objectif de cette thèse est de développer un nouveau procédé de précipitation afin d'obtenir des alumines γ présentant des propriétés texturales originales vis-à-vis de celles préparées de façon conventionnelle par précipitation de boehmite en réacteur agité. Pour cela, les influences combinées du précurseur, de la technologie de mélange et du temps de micromélange sur les propriétés physiques du produit final ont été étudiées. Ce travail de thèse propose donc une comparaison de trois technologies de mélange : un réacteur agité conventionnel, un réacteur à disque tournant et un disperseur rotor-stator. Les gammes de temps de micromélange accessibles avec chacun de ces réacteurs sont déterminées par la méthode iodure-iodate. L'étude porte sur la précipitation de deux précurseurs de l'alumine : la boehmite, classiquement utilisée, ainsi que la NH4-dawsonite, dont l'intérêt pour la préparation de supports de catalyseurs est plus récent. Leur solubilité est estimée dans la mesure du possible à l'aide des données thermodynamiques de la littérature. Dans le cadre de cette étude préliminaire, un modèle de suivi de la sursaturation en fonction du temps de micromélange est mis en place à l'aide des équations cinétiques de la précipitation de la boehmite. La caractérisation de la NH4-dawsonite précipitée en réacteur agité met en évidence l'intérêt de ce précurseur pour obtenir des alumines à forte porosité présentant des diamètres poreux moyens entre 10 et 30 nm. Une nuance est toutefois apportée aux fortes surfaces spécifiques généralement revendiquées sur ce matériau dans la littérature. Malgré tout, les propriétés texturales de l'alumine ex-dawsonite présentent une évolution thermique atypique lui permettant de se démarquer de l'alumine ex-boehmite. L'étude de la précipitation en mélangeur rapide met en évidence une grande différence de comportement entre les deux précurseurs. Contrairement à la boehmite, la forte sensibilité de la NH4-dawsonite au temps de micromélange permet d'obtenir une large gamme de propriétés texturales. Ce travail de thèse confirme donc l'intérêt de la NH4-dawsonite comme précurseur alternatif de l'alumine pour obtenir des propriétés texturales originales. L'utilisation de plusieurs systèmes précurseur / technologie de mélange s'avère également prometteuse pour couvrir une large gamme de propriétés texturales

Control of catalyst supports porosity is an important challenge for the refining industry. The aim of this thesis is to develop a new precipitation process in order to obtain γ-alumina supports exhibiting new textural properties compared with those prepared by the conventional boehmite precipitation route in stirred tank reactor. For that purpose, combined influences of precursor, mixing technology and micromixing time on the final product physical properties were studied.Three mixing technologies were compared: a classic stirred tank reactor, a sliding surface mixing device and a…

Advisors/Committee Members: Puel, François (thesis director), Digne, Mathieu (thesis director), Boualleg, Malika (thesis director), Colson, Didier (thesis director), Salvatori, Fabien (thesis director).

Subjects/Keywords: Alumine; Boehmite; Dawsonite; Précipitation; Sursaturation; Micromélange; Mélangeur rapide; Alumina; Boehmite; Dawsonite; Precipitation; Supersaturation; Micromixing; Fast contacting mixers; 540

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lafficher, R. (2016). Nouveau procédé de précipitation pour la synthèse d’alumine : New precipitation process for alumina synthesis. (Doctoral Dissertation). Lyon. Retrieved from http://www.theses.fr/2016LYSE1248

Chicago Manual of Style (16^th Edition):

Lafficher, Robin. “Nouveau procédé de précipitation pour la synthèse d’alumine : New precipitation process for alumina synthesis.” 2016. Doctoral Dissertation, Lyon. Accessed February 27, 2021. http://www.theses.fr/2016LYSE1248.

MLA Handbook (7^th Edition):

Lafficher, Robin. “Nouveau procédé de précipitation pour la synthèse d’alumine : New precipitation process for alumina synthesis.” 2016. Web. 27 Feb 2021.

Vancouver:

Lafficher R. Nouveau procédé de précipitation pour la synthèse d’alumine : New precipitation process for alumina synthesis. [Internet] [Doctoral dissertation]. Lyon; 2016. [cited 2021 Feb 27]. Available from: http://www.theses.fr/2016LYSE1248.

Council of Science Editors:

Lafficher R. Nouveau procédé de précipitation pour la synthèse d’alumine : New precipitation process for alumina synthesis. [Doctoral Dissertation]. Lyon; 2016. Available from: http://www.theses.fr/2016LYSE1248

12. Cheng, Khley. Elaboration de nano-photocatalyseurs mixtes à base d'oxide de métal ZrᵪTi₁-ᵪO₂ : Elaboration of mixed metal oxide ZrᵪTi₁-ᵪO₂ nano-photocatalysts.

Degree: Docteur es, Génie des procédés, 2018, Sorbonne Paris Cité

URL: http://www.theses.fr/2018USPCD039

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Ce présent mémoire porte sur l'élaboration de composites nanoparticulaires ZrᵪTi₁-ᵪO₂, de l'étape de nucléation des nanoparticules au solide cristallin massif ainsi que sur leur application… (more)

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Ce présent mémoire porte sur l'élaboration de composites nanoparticulaires ZrᵪTi₁-ᵪO₂, de l'étape de nucléation des nanoparticules au solide cristallin massif ainsi que sur leur application en photocatalyse. La synthèse a été réalisée dans un réacteur sol-gel à micromélange utilisant des précurseurs d'isopropoxyde de titane (IV) et de propoxyde de zirconium (IV) dans différents rapports molaires et taux d'hydrolyse. Ces expériences ont conduit à la formation de nanoparticules amorphes monodisperses oxo-alcoxy de zirconium titane(ZTOA) de rayon R = 1,6 nm pour 0 ≤ x ≤ 0,2, R = 2,1 nm pour 0,3 ≤ x ≤ 0,6 et des particules oxo-alcoxy de zirconium (ZOA) de rayon R = 1,8 nm pour 0,7 ≤ x ≤ 1. Celles-ci se transforment, après traitement thermique, en cristallite nanoporeux respectivement dans les phases anatase, orthorhombique et monoclinique / tétragonale. La température du début de transition dépend significativement de la composition x. Les particules d'anatase de composition 0 < x < 0,2 ont été sélectionnées pour des applications photocatalytiques en phase gazeuse (éthylène) et en phase liquide (MB et phénol). La meilleure performance photocatalytique a été obtenue pour un matériau de composition optimale x = 0,0425 et traitée thermiquement à 500 °C. L'activité la plus forte enregistrée est pratiquement deux fois celle du TiO₂ pur préparé dans les mêmes conditions.

The PhD study is focused on synthesis of nanoparticulate ZrᵪTi₁-ᵪO₂ composites : from nucleation stage of nanoparticles to bulk crystalline solid and their application in photocatalysis. The synthesis was achieved in a sol-gel micromixing reactor using titanium (IV) isopropoxide and zirconium(IV) propoxide precursors in different molar and hydrolysis ratios, resulting in monodispersed zirconium-titanium oxo-alkoxy (ZTOA) nanoparticles : R=1.6 nm for 0≤x≤0.2, R=2.1 nm for 0.3≤x≤0.6 with orthorambic and ZOA of R=1.8 nm for 0.7≤x≤1. They convert after heat treatment to nanoporous crystallite in respectively anatase, orthorambic and monoclinic/tetragonal crystalline phases, which onset temperature depend on x. The anatase compositions (0≤x≤0.2) were selected for photocatalytic applications in gas phase (ethylene) and liquid phase (MB and phenol) degradation. The optimum composition x=0.0425 heat treated at 500 °C revealed the strongest activity, two times higher than pure TiO₂. We found that the photocatalytic activity directly correlates with the specific surface area.

Advisors/Committee Members: Kanaev, Andrei (thesis director), Chhor, Y Sok Khay (thesis director).

Subjects/Keywords: Composite ZrᵪTi₁-ᵪO₂; Réacteur sol-Gel à micromélange; Nanoparticules; Photocatalyseur; Composite ZrᵪTi₁-ᵪO₂; Sol-Gel micromixing reactor; Nanoparticles; Photocatalyst

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cheng, K. (2018). Elaboration de nano-photocatalyseurs mixtes à base d'oxide de métal ZrᵪTi₁-ᵪO₂ : Elaboration of mixed metal oxide ZrᵪTi₁-ᵪO₂ nano-photocatalysts. (Doctoral Dissertation). Sorbonne Paris Cité. Retrieved from http://www.theses.fr/2018USPCD039

Chicago Manual of Style (16^th Edition):

Cheng, Khley. “Elaboration de nano-photocatalyseurs mixtes à base d'oxide de métal ZrᵪTi₁-ᵪO₂ : Elaboration of mixed metal oxide ZrᵪTi₁-ᵪO₂ nano-photocatalysts.” 2018. Doctoral Dissertation, Sorbonne Paris Cité. Accessed February 27, 2021. http://www.theses.fr/2018USPCD039.

MLA Handbook (7^th Edition):

Cheng, Khley. “Elaboration de nano-photocatalyseurs mixtes à base d'oxide de métal ZrᵪTi₁-ᵪO₂ : Elaboration of mixed metal oxide ZrᵪTi₁-ᵪO₂ nano-photocatalysts.” 2018. Web. 27 Feb 2021.

Vancouver:

Cheng K. Elaboration de nano-photocatalyseurs mixtes à base d'oxide de métal ZrᵪTi₁-ᵪO₂ : Elaboration of mixed metal oxide ZrᵪTi₁-ᵪO₂ nano-photocatalysts. [Internet] [Doctoral dissertation]. Sorbonne Paris Cité; 2018. [cited 2021 Feb 27]. Available from: http://www.theses.fr/2018USPCD039.

Council of Science Editors:

Cheng K. Elaboration de nano-photocatalyseurs mixtes à base d'oxide de métal ZrᵪTi₁-ᵪO₂ : Elaboration of mixed metal oxide ZrᵪTi₁-ᵪO₂ nano-photocatalysts. [Doctoral Dissertation]. Sorbonne Paris Cité; 2018. Available from: http://www.theses.fr/2018USPCD039

Université de Lorraine

13. Pinot, Jordanna. Caractérisation du micromélange par la réaction iodure-iodate en milieu visqueux : Characterization of micromixing by the iodide-iodate reaction in viscous medium.

Degree: Docteur es, Génie des procédés et des produits, 2015, Université de Lorraine

URL: http://www.theses.fr/2015LORR0140

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Le micromélange, ou mélange à l'échelle moléculaire, a une influence déterminante sur la qualité des produits, la sélectivité, et le rendement de réactions d'importance industrielle… (more)

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Le micromélange, ou mélange à l'échelle moléculaire, a une influence déterminante sur la qualité des produits, la sélectivité, et le rendement de réactions d'importance industrielle comme les réactions de polymérisation. A l'heure actuelle, les systèmes chimiques existants sont bien adaptés à l'étude du micromélange de produits faiblement visqueux, mais il n'existe pas de méthode simple et opérationnelle pour les fluides plus visqueux. Inscrite dans le cadre du projet ANR PROCIP, l'étude a consisté à mettre en place une nouvelle méthode de quantification de l'efficacité du micromélange en milieu visqueux dans des réacteurs agités. La méthode utilisée s'inspire d'un système chimique basé sur deux réactions concurrentes, le système de réaction test iodure-iodate, dont la sélectivité d'un des produits est une mesure de l'efficacité du micromélange. L'approche propose un nouveau protocole basé sur le choix d'un tampon phosphate et l'utilisation de l'HydroxyEthylCellulose (HEC, 720 000 g/mol) comme agent viscosifiant inerte, qui possède un fort pouvoir viscosifiant permettant d'augmenter significativement la viscosité sans en ajouter plus de 1 % en masse dans le milieu. Des essais de caractérisation du micromélange en réacteur agité ont mis en évidence le ralentissement du micromélange au fur et à mesure que la viscosité augmente pour des pourcentages en HEC inférieurs à 0,5 %. Par contre, au-delà de 0,5 %, une « amélioration » du micromélange a été observée dans une large gamme de conditions expérimentales (différentes concentrations de réactifs, positions de l'injection, vitesses d'agitation et mobiles d'agitation). Plusieurs causes potentielles ont été formulées en vue d'expliquer ce phénomène et les cinétiques des réactions mises en jeu ont également été étudiées en présence de l'agent viscosifiant HEC et s'avèrent être inchangées. Enfin, une étude des interactions possibles entre les espèces iodées et l'HEC a été réalisée pour étudier l'existence d'une réaction parasite qui pourrait expliquer les résultats obtenus

Micromixing, or mixing at the molecular scale, has a decisive influence on product quality, selectivity and yield of industrially important reactions such as polymerization reactions. Currently, the existing chemical systems are well suited to the study of micromixing of low viscosity products, but no reliable characterization method exists for highly viscous media. As a part of the ANR project PROCIP, the study consisted in developing a new method to quantify the efficiency of micromixing in viscous media in stirred reactors. The method used is inspired by a chemical system based on two competitive reactions, the iodide-iodate test reaction system whose selectivity of a product is a measure of the micromixing efficiency. The approach proposes a new protocol based on a phosphate buffer and the use of HydroxyEthylCellulose (HEC, 720,000 g / mol) as an inert viscosifying agent, enabling to significantly increase the viscosity without adding more than 1 % by mass in the medium. Characterization of…

Advisors/Committee Members: Falk, Laurent (thesis director).

Subjects/Keywords: Micromélange; Milieu visqueux; HEC; Réaction test iodure-Iodate; Réacteur agité; Micromixing; Viscous medium; HEC; Iodide-Iodate test reaction; Stirred tank reactor; 541.39

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pinot, J. (2015). Caractérisation du micromélange par la réaction iodure-iodate en milieu visqueux : Characterization of micromixing by the iodide-iodate reaction in viscous medium. (Doctoral Dissertation). Université de Lorraine. Retrieved from http://www.theses.fr/2015LORR0140

Chicago Manual of Style (16^th Edition):

Pinot, Jordanna. “Caractérisation du micromélange par la réaction iodure-iodate en milieu visqueux : Characterization of micromixing by the iodide-iodate reaction in viscous medium.” 2015. Doctoral Dissertation, Université de Lorraine. Accessed February 27, 2021. http://www.theses.fr/2015LORR0140.

MLA Handbook (7^th Edition):

Pinot, Jordanna. “Caractérisation du micromélange par la réaction iodure-iodate en milieu visqueux : Characterization of micromixing by the iodide-iodate reaction in viscous medium.” 2015. Web. 27 Feb 2021.

Vancouver:

Pinot J. Caractérisation du micromélange par la réaction iodure-iodate en milieu visqueux : Characterization of micromixing by the iodide-iodate reaction in viscous medium. [Internet] [Doctoral dissertation]. Université de Lorraine; 2015. [cited 2021 Feb 27]. Available from: http://www.theses.fr/2015LORR0140.

Council of Science Editors:

Pinot J. Caractérisation du micromélange par la réaction iodure-iodate en milieu visqueux : Characterization of micromixing by the iodide-iodate reaction in viscous medium. [Doctoral Dissertation]. Université de Lorraine; 2015. Available from: http://www.theses.fr/2015LORR0140

New Jersey Institute of Technology

14. Uehara-Nagamine, Ernesto. Modeling and experimental validation of a single-feed semi-batch precipitation process.

Degree: PhD, Chemical Engineering, Chemistry and Environmental Science, 2001, New Jersey Institute of Technology

URL: https://digitalcommons.njit.edu/dissertations/506

► Crystallization is a widely practiced unit operation throughout the chemical and pharmaceutical process industries. Despite its widespread application, crystallization still suffers a disproportionate number… (more)

▼ Crystallization is a widely practiced unit operation throughout the chemical and pharmaceutical process industries. Despite its widespread application, crystallization still suffers a disproportionate number of process difficulties due to the complexity of the steps involved in the process. In particular, the final characteristics of the product are strongly affected by the mixing conditions during the process. The development of a validated modeling approach would be highly valuable for the successful prediction of the crystal characteristics under differing mixing conditions. In the present work, the single-feed semi-batch precipitation process of barium sulfate in a stirred tank was experimentally studied and numerically predicted using a micromixing model based on CFD. A commercial CFD package (FLUENT) was used to simulate the flow field and predict the energy dissipation rate distributions within the reactor. The precipitation zone originated from the feed point was tracked using a random walk model. Available correlations were used for the calculation of the nucleation and crystal growth rates. The mass transfer coefficient for the crystal growth was assumed to be dependent on both the average crystal size and the local energy dissipation rate. Finally, a micromixing model (E-Model) was incorporated to predict the effects on the final crystal size distribution of a number of operating and geometric variables as well as the effect of vessel scale. An extensive number of barium sulfate precipitation experiments were conducted to determine the crystal size distribution and validate the proposed model. The effect of the process variables (such as volume ratio, mean initial concentration and stoichiometry ratio), operating conditions (including impeller speed, diameter and off-bottom clearance), and vessel scale on the crystal size distribution were experimentally determined and numerically predicted. In general, very good agreement between experimental data and model predictions was obtained. The model was typically able to capture all of the most important features of the precipitation process. The proposed approach has a significant potential for the prediction of the performance of crystallization processes in industrial applications. Advisors/Committee Members: Piero M. Armenante, Basil Baltzis, Dana E. Knox.

Subjects/Keywords: crystallization; single-feed; semi-batch; precipitation process micromixing model; Chemical Engineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Uehara-Nagamine, E. (2001). Modeling and experimental validation of a single-feed semi-batch precipitation process. (Doctoral Dissertation). New Jersey Institute of Technology. Retrieved from https://digitalcommons.njit.edu/dissertations/506

Chicago Manual of Style (16^th Edition):

Uehara-Nagamine, Ernesto. “Modeling and experimental validation of a single-feed semi-batch precipitation process.” 2001. Doctoral Dissertation, New Jersey Institute of Technology. Accessed February 27, 2021. https://digitalcommons.njit.edu/dissertations/506.

MLA Handbook (7^th Edition):

Uehara-Nagamine, Ernesto. “Modeling and experimental validation of a single-feed semi-batch precipitation process.” 2001. Web. 27 Feb 2021.

Vancouver:

Uehara-Nagamine E. Modeling and experimental validation of a single-feed semi-batch precipitation process. [Internet] [Doctoral dissertation]. New Jersey Institute of Technology; 2001. [cited 2021 Feb 27]. Available from: https://digitalcommons.njit.edu/dissertations/506.

Council of Science Editors:

Uehara-Nagamine E. Modeling and experimental validation of a single-feed semi-batch precipitation process. [Doctoral Dissertation]. New Jersey Institute of Technology; 2001. Available from: https://digitalcommons.njit.edu/dissertations/506

Iowa State University

15. Madadi Kandjani, Ehsan. Quadrature-based models for multiphase and turbulent reacting flows.

Degree: 2017, Iowa State University

URL: https://lib.dr.iastate.edu/etd/16172

► The simulation of physical systems requires accurate and robust methods with relatively low cost and it is still the challenge in many applications of engineering… (more)

▼ The simulation of physical systems requires accurate and robust methods with relatively low cost and it is still the challenge in many applications of engineering processes, specifically in multiphase flow systems. Soot formation, distribution of the aerosols in the atmosphere, reactive precipitation, and combustion modeling are some examples of these processes. Computer simulations of theses systems require a model that can be adapted to that reality. In this study, a quadrature based method of moments (QBMM) is used to address the problems related to the reactive multiphase flow systems. First, the log-normal kernel density function is implemented into the extended quadrature method of moments (Ln-EQMOM). Ln-EQMOM is verified reconstructing the NDF and calculating the moments of a distribution obtained by the linear combination of two log-normal distributions. Later, this numerical procedure is used for problems of aggregation and breakup of fine particles to solve the population balance equation (PBE). The results are compared to the rigorous solutions reported for the cases under consideration \citep{vanni2000}. Finally, the method is verified using two analytically known problems (it{e.g.} coalescence and condensation). In comparison to EQMOM with Γ kernel density function \citep{yuan2012}, Ln-EQMOM is faster in terms of computations and it preserves the moments more accurately. Then EQMOM with β kernel density function is implemented to approximate the solution of the transport equation for the composition probability density function (PDF) of a passive scalar using the Fokker-Planck model to treat the molecular mixing term. The results then compared in a similar condition to those obtained with direct numerical simulation (DNS). The L₂ norm of the PDF is reported for two test cases that have been considered. Later the new approach is introduced to address the problems includes the mixing and reaction. Conditional quadrature method of moments (CQMOM) and using the joint composition PDF for the mixture fraction and progress variables, it is possible to address the problems with two consecutive competitive reactions, one reaction and fast reaction, all including the mixing of reactants. direct quadrature method of moments (DQMOM) also expressed for the joint composition PDF. Results obtained with CQMOM and DQMOM are compared with each other. Finally, the CQMOM approach for mixing problems was tested considering two consecutive competitive reactions to verify the implementation and validate the proposed approach. Coupled mixing-PBE approach was then used to investigate polymer aggregation in a multi-inlet vortex reactor (MIVR), typically used to perform flash nanoprecipitation for the production of nanoparticles used in pharmaceutical applications.

Subjects/Keywords: Aggregation and Breakage; Extended Quadrature Method of Moments; Fokker-Planck Micromixing Closure; Log-normal Kernel Density Function; Mixing and Reacting Flows; Population Balance Equation; Mechanical Engineering

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APA (6^th Edition):

Madadi Kandjani, E. (2017). Quadrature-based models for multiphase and turbulent reacting flows. (Thesis). Iowa State University. Retrieved from https://lib.dr.iastate.edu/etd/16172

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Madadi Kandjani, Ehsan. “Quadrature-based models for multiphase and turbulent reacting flows.” 2017. Thesis, Iowa State University. Accessed February 27, 2021. https://lib.dr.iastate.edu/etd/16172.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Madadi Kandjani, Ehsan. “Quadrature-based models for multiphase and turbulent reacting flows.” 2017. Web. 27 Feb 2021.

Vancouver:

Madadi Kandjani E. Quadrature-based models for multiphase and turbulent reacting flows. [Internet] [Thesis]. Iowa State University; 2017. [cited 2021 Feb 27]. Available from: https://lib.dr.iastate.edu/etd/16172.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Madadi Kandjani E. Quadrature-based models for multiphase and turbulent reacting flows. [Thesis]. Iowa State University; 2017. Available from: https://lib.dr.iastate.edu/etd/16172

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

16. WOO XING YI. Modeling and simulation of antisolvent crystallization: mixing and control.

Degree: 2007, National University of Singapore

URL: http://scholarbank.nus.edu.sg/handle/10635/16203

Subjects/Keywords: Antisolvent crystallization; Computational fluid dynamics; Micromixing; Population balance; Crystal size distribution; Control

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

YI, W. X. (2007). Modeling and simulation of antisolvent crystallization: mixing and control. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/16203

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

YI, WOO XING. “Modeling and simulation of antisolvent crystallization: mixing and control.” 2007. Thesis, National University of Singapore. Accessed February 27, 2021. http://scholarbank.nus.edu.sg/handle/10635/16203.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

YI, WOO XING. “Modeling and simulation of antisolvent crystallization: mixing and control.” 2007. Web. 27 Feb 2021.

Vancouver:

YI WX. Modeling and simulation of antisolvent crystallization: mixing and control. [Internet] [Thesis]. National University of Singapore; 2007. [cited 2021 Feb 27]. Available from: http://scholarbank.nus.edu.sg/handle/10635/16203.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

YI WX. Modeling and simulation of antisolvent crystallization: mixing and control. [Thesis]. National University of Singapore; 2007. Available from: http://scholarbank.nus.edu.sg/handle/10635/16203

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Central Florida

17. Yakhshi-Tafti, Ehsan. Flow Visualization In Microfluidic Expansion And Mixing.

Degree: 2009, University of Central Florida

URL: https://stars.library.ucf.edu/etd/4096

► Micro particle image velocimetry (microPIV) is a non-intrusive tool for visualizing flow in micron-scale conduits. Using this investigative instrument, two experimental studies were performed… (more)

▼ Micro particle image velocimetry (microPIV) is a non-intrusive tool for visualizing flow in micron-scale conduits. Using this investigative instrument, two experimental studies were performed to understand flow behaviors in microfluidic channels - a sudden expansion step flow and laminar velocity profile variation in diffusion driven mixing. First, flow in a backward facing step feature (1:5 expansion ratio) in a microchannel was taken as the subject of microPIV flow visualization. The onset and development of a recirculation flow was studied as a function of flow rate. This flow pattern was further used to investigate two major parameters affecting microPIV measurements; the depth-of-focus and recording time-intervals between images in a microPIV image pair. The onset of recirculation was initiated at flow rates that correspond to Reynolds numbers, Re>95, which is well beyond the typical working range of microfluidic devices (Re=0.01-10). The recirculation flow has a 3D structure due to the dimensions of the microchannel and the effect of no slip condition on the walls. Ensemble cross-correlation was found not to be sensitive to variations of depth-of-focus and the output flow fields were similar as long as the overall optical focus remained within the upper and lower bounds of the microchannel. However, variations of time intervals between images in a microPIV pair, resulted in quantitatively and qualitatively different flow patterns for a given constant flow rate and depth-of-focus. In the second experiment, the effect of the laminar velocity profile and its variation on mixing phenomena at the reduced scale is studied. It is shown that the diffusive mass flux between two miscible streams, flowing in a laminar regime in a microchannel, is enhanced if the velocity at their diffusion interface is increased. Based on this idea, an in-plane passive micromixing concept is proposed and implemented in a working device (sigma micromixer). This mixer shows considerable mixing performance by periodically varying the flow velocity profile, such that the maximum of the profile coincides with the transversely progressing diffusion fronts repeatedly throughout the mixing channel. microPIV has been used to visualize the behavior of laminar flow inside the micromixer device and to confirm the periodic variation of the velocity profile through the mixing channel. Advisors/Committee Members: Kumar, Ranganathan.

Subjects/Keywords: micro Particle Image Velocimetry; backward facing step flow; micromixing;

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APA (6^th Edition):

Yakhshi-Tafti, E. (2009). Flow Visualization In Microfluidic Expansion And Mixing. (Masters Thesis). University of Central Florida. Retrieved from https://stars.library.ucf.edu/etd/4096

Chicago Manual of Style (16^th Edition):

Yakhshi-Tafti, Ehsan. “Flow Visualization In Microfluidic Expansion And Mixing.” 2009. Masters Thesis, University of Central Florida. Accessed February 27, 2021. https://stars.library.ucf.edu/etd/4096.

MLA Handbook (7^th Edition):

Yakhshi-Tafti, Ehsan. “Flow Visualization In Microfluidic Expansion And Mixing.” 2009. Web. 27 Feb 2021.

Vancouver:

Yakhshi-Tafti E. Flow Visualization In Microfluidic Expansion And Mixing. [Internet] [Masters thesis]. University of Central Florida; 2009. [cited 2021 Feb 27]. Available from: https://stars.library.ucf.edu/etd/4096.

Council of Science Editors:

Yakhshi-Tafti E. Flow Visualization In Microfluidic Expansion And Mixing. [Masters Thesis]. University of Central Florida; 2009. Available from: https://stars.library.ucf.edu/etd/4096

18. Boehm, Michael. EXPERIMENTAL INVESTIGATION OF TWO-PHASE PENETRATING FLOW OF NEWTONIAN AND NON-NEWTONIAN POLYMERIC FLUIDS AND DEVELOPMENT OF PRACTICAL APPLICATIONS IN DRUG/GENE DELIVERY.

Degree: PhD, Chemical Engineering, 2009, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1253548237

► Rheology, simply stated as the study of the flow and deformation of matter, is afield with grand importance yet a meager following. Be it… (more)

▼ Rheology, simply stated as the study of the flow and deformation of matter, is afield with grand importance yet a meager following. Be it velocity distributions andturbulence within the Sun or the flow of jelly from your donut’s center, the field ofrheology offers tools to understanding the simple to the complex. For example, onesuch simple experiment that hides far more complex dynamics is the flow of a lowviscosity fluid through a much higher viscosity liquid. This is also known as coringflow and has been studied extensively for the macro-scale. The dynamics for coringflow have not been studied, to the best of the author's knowledge, on the micro-scaleand it is that disparity the research detailed here addresses. There are many important aspects to consider before performing multiphasemicro-fluidic research including what micro-fabrication methods are used, how themicrochip is interfaced to the macro-world, how the fluids will behave, and how themicro-channel geometry will affect the dynamics. This dissertation addresses thosetopics as they apply to the research performed and detailed here. Three differentfabrication techniques are explained, detailed, and used to highlight the benefits anddrawbacks of working on the micro-scale. Bonding is also an important part offabrication and so two different methods are discussed. Finally, the way a microchip isinterfaced to the macro-world affects the correlations that can be made. Three differentinterfacing systems that worked well are presented. The fundamental process of coring on the micro-scale is investigated andexplained for circular, square, and rectangular geometries. The simple case of aNewtonian coating fluid was researched first, followed by the case of a viscoelasticcoating fluid, and finally the case where the coring fluid contained a surfactant. It wasfound that, in general, micro-scale coring matches that of the macro-scale except for thecase of a viscoelastic coating fluid. New bubble behavior was observed for high flowrates through a viscoelastic coating fluid. As engineers, we wrestle something practical out of our understanding of thefundamental. This principle was the driving motivation behind the three practicalapplications of micro-scale coring flow that were. Coring flow was used to add afunctional coating to capillaries for use in Capillary Electrophoresis, to coat a staticmixer, and to create nozzle-like structures in a micro-channel. The final goal of thesepractical applications was to develop a toolbox of procedures and data that can be usedin a wide array of fields including (a) coatings to reduce non-specific binding indrug/gene delivery applications, (b) coatings for separation and detection techniqueslike Capillary Electrophoresis, and (c) a simple means to smoothing rough channelsmade via micro-/nano-machining. Advisors/Committee Members: Koelling, Kurt (Advisor).

Subjects/Keywords: Chemical Engineering; microfluidics; CNC machining; functional coatings; bubble; viscoelastic; micromixing

12 more images…

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APA (6^th Edition):

Boehm, M. (2009). EXPERIMENTAL INVESTIGATION OF TWO-PHASE PENETRATING FLOW OF NEWTONIAN AND NON-NEWTONIAN POLYMERIC FLUIDS AND DEVELOPMENT OF PRACTICAL APPLICATIONS IN DRUG/GENE DELIVERY. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1253548237

Chicago Manual of Style (16^th Edition):

Boehm, Michael. “EXPERIMENTAL INVESTIGATION OF TWO-PHASE PENETRATING FLOW OF NEWTONIAN AND NON-NEWTONIAN POLYMERIC FLUIDS AND DEVELOPMENT OF PRACTICAL APPLICATIONS IN DRUG/GENE DELIVERY.” 2009. Doctoral Dissertation, The Ohio State University. Accessed February 27, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1253548237.

MLA Handbook (7^th Edition):

Boehm, Michael. “EXPERIMENTAL INVESTIGATION OF TWO-PHASE PENETRATING FLOW OF NEWTONIAN AND NON-NEWTONIAN POLYMERIC FLUIDS AND DEVELOPMENT OF PRACTICAL APPLICATIONS IN DRUG/GENE DELIVERY.” 2009. Web. 27 Feb 2021.

Vancouver:

Boehm M. EXPERIMENTAL INVESTIGATION OF TWO-PHASE PENETRATING FLOW OF NEWTONIAN AND NON-NEWTONIAN POLYMERIC FLUIDS AND DEVELOPMENT OF PRACTICAL APPLICATIONS IN DRUG/GENE DELIVERY. [Internet] [Doctoral dissertation]. The Ohio State University; 2009. [cited 2021 Feb 27]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1253548237.

Council of Science Editors:

Boehm M. EXPERIMENTAL INVESTIGATION OF TWO-PHASE PENETRATING FLOW OF NEWTONIAN AND NON-NEWTONIAN POLYMERIC FLUIDS AND DEVELOPMENT OF PRACTICAL APPLICATIONS IN DRUG/GENE DELIVERY. [Doctoral Dissertation]. The Ohio State University; 2009. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1253548237

19. Lee, Michael. Développement de micro-outils pour la biodétection, les micromélangeurs et les microfiltres : Development of micro-tools for biodetection, micromixing, and microfiltering.

Degree: Docteur es, Micro-NanoBiotechnologie, 2013, Université Claude Bernard – Lyon I

URL: http://www.theses.fr/2013LYO10119

►

Ce travail de thèse est consacré au développement de micro-outils pour des applications dans le domaine biomédical. Il se compose de trois volets: le premier… (more)

▼

Ce travail de thèse est consacré au développement de micro-outils pour des applications dans le domaine biomédical. Il se compose de trois volets: le premier volet est dédié au développement et caractérisation d’un immunocapteur pour la détection d'une cytokine anti-inflammatoire (Interleukine-10 (IL-10)) en utilisant le transistor EOS (Electrolyte-Oxide-Semiconductor) à base d’un nouveau diélectrique à haute constante diélectrique (high-k): l’oxyde d'hafnium (HfO2) utilisé comme transducteur. Le deuxième et le troisième volet sont consacrés respectivement à la conception et réalisation d’une part d’un micro-mélangeur ‘passif’ et d’autre part d’un micro-filtre totalement flexible par des méthodes douces de microfabrication. Des moules souples en poly(diméthylsiloxane) (PDMS) micro-structurés sont préparés à partir d'un moule mère en silicium qui a été préalablement structuré par lithographie électronique et gravure ionique réactive (RIE). Un procédé de collage direct a été mis au point pour fabriquer ces dispositifs «PDMS-sur-Polymère» suffisamment résistants en pression pour permettre des études de mélange de fluides ou pour filtrer des microparticules

The work in this thesis is devoted to the develoment of micro-tools for the application in the biomedical domain. It is composed of three main chapters. The first chapter is devoted on the development and characterization of an immunosensor for the detection of an anti-inflammatory cytokine (Interleukin-10 (IL-10) and applied as an EOS (Electrolyte-Oxide-Semiconductor) transistor as a base for a new dielectric material with a high dielectric (high-k): hafnium oxide used as a transducer. The second and third main chapters are dedicated respectively to the conception and realization of a passive micromixer and microfilter that are both flexible using soft lithography microfabrication. The flexible micro-structured molds in poly(dimethylsiloxane) (PDMS) were prepared to peel from the master silicon mold which was beforehand structured by electron beam lithography and reactive ion etching (RIE). A process for direct covalent bonding was worked out for the fabrication of devices “PDMS bonded to Polymers” that were sufficiently resistant in pressure and permitted the studies of mixing liquids or to filter microparticles

Advisors/Committee Members: Errachid El Salhi, Abdelhamid (thesis director), Zine Loukili, Nadia (thesis director).

Subjects/Keywords: Oxyde d'hafnium; Microparticules de PLGA; Spectroscopie d'impédance électrochimique; Micro-tamponage; Lithographie douce; PH-EOS; Cytokine-CNT/EOS; Micro-mélangeur; Hafnium oxide; PLGA microparticles; Electrochemical impedance spectroscopy; Microcontact printing; Soft-lithography; PH-EOS; Cytokine-CNT/EOS; Micromixing; 540

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lee, M. (2013). Développement de micro-outils pour la biodétection, les micromélangeurs et les microfiltres : Development of micro-tools for biodetection, micromixing, and microfiltering. (Doctoral Dissertation). Université Claude Bernard – Lyon I. Retrieved from http://www.theses.fr/2013LYO10119

Chicago Manual of Style (16^th Edition):

Lee, Michael. “Développement de micro-outils pour la biodétection, les micromélangeurs et les microfiltres : Development of micro-tools for biodetection, micromixing, and microfiltering.” 2013. Doctoral Dissertation, Université Claude Bernard – Lyon I. Accessed February 27, 2021. http://www.theses.fr/2013LYO10119.

MLA Handbook (7^th Edition):

Lee, Michael. “Développement de micro-outils pour la biodétection, les micromélangeurs et les microfiltres : Development of micro-tools for biodetection, micromixing, and microfiltering.” 2013. Web. 27 Feb 2021.

Vancouver:

Lee M. Développement de micro-outils pour la biodétection, les micromélangeurs et les microfiltres : Development of micro-tools for biodetection, micromixing, and microfiltering. [Internet] [Doctoral dissertation]. Université Claude Bernard – Lyon I; 2013. [cited 2021 Feb 27]. Available from: http://www.theses.fr/2013LYO10119.

Council of Science Editors:

Lee M. Développement de micro-outils pour la biodétection, les micromélangeurs et les microfiltres : Development of micro-tools for biodetection, micromixing, and microfiltering. [Doctoral Dissertation]. Université Claude Bernard – Lyon I; 2013. Available from: http://www.theses.fr/2013LYO10119

20. Nironi, Chiara. Concentration fluctuations of a passive scalar in a turbulent boundary layer : Les fluctuations de concentration d'un scalaire passif dans une couche limite turbulente.

Degree: Docteur es, Mécanique, Energétique, Génie Civil et Acoustique, 2013, Ecully, Ecole centrale de Lyon

URL: http://www.theses.fr/2013ECDL0015

►

Cette étude, menée principalement par des moyens expérimentaux, analyse la dynamique des fluctuations de concentration produites au sein d’un panache d’un scalaire passif émis par… (more)

▼

Cette étude, menée principalement par des moyens expérimentaux, analyse la dynamique des fluctuations de concentration produites au sein d’un panache d’un scalaire passif émis par une source ponctuelle dans une couche limite turbulente. En étendant le travail de Fackrell and Robins (1982) sur les fluctuations de concentration, on décrit l’évolution des quatre premiers moments de la concentration et on étudie l’influence des conditions à la source (telles que la taille et la hauteur de la source et la vitesse de sortie) sur les moments mêmes. L’étude est complétée par une description détaillée des statistiques du champ de vitesse dans la couche limite, comprenant des informations sur la structure spatiale et temporelle de la turbulence. Cette base de données expérimentale a été utilisée pour valider deux différentes approches à la modélisation de la dispersion: un modèle analytique de meandering et un modèle Lagrangien stochastique avec un schéma de micro mélange.

This experimental study analyses the dynamics of concentration fluctuations in a passive plume emitted by a point source within the turbulent boundary layer. We aim to extend the popular study of Fackrell and Robins (1982) about concentration fluctuations and fluxes from point sources by including third and fourth moments of concentration. We also further inquire into the influence of source conditions, such as the source size, source elevation and emission velocity, on higher order concentration moments. The data set is completed by a detailed description of the velocity statistics within the TBL, with exhaustive information on both the temporal and spatial structure of the flow. The experimental data-set has been used to test two different modeling ap- proaches: an analytical meandering plume model (in one and in three dimen- sions) and a Lagrangian stochastic micro-mixing model.

Advisors/Committee Members: Perkins, Richard (thesis director), Salizzoni, Pietro (thesis director).

Subjects/Keywords: Fluctuations de concentration; Fonction densité de probabilité; Couche limite atmosphérique; Dispersion atmosphérique; Modèle analytique de meandering; Modèle Lagrangian stochastique; Micro mélange; Concentration fluctuations; Concentration PDF; Turbulent boundary layer; Atmospheric dispersion; Plume meandering model; Lagrangian stochastic model; Micromixing

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APA (6^th Edition):

Nironi, C. (2013). Concentration fluctuations of a passive scalar in a turbulent boundary layer : Les fluctuations de concentration d'un scalaire passif dans une couche limite turbulente. (Doctoral Dissertation). Ecully, Ecole centrale de Lyon. Retrieved from http://www.theses.fr/2013ECDL0015

Chicago Manual of Style (16^th Edition):

Nironi, Chiara. “Concentration fluctuations of a passive scalar in a turbulent boundary layer : Les fluctuations de concentration d'un scalaire passif dans une couche limite turbulente.” 2013. Doctoral Dissertation, Ecully, Ecole centrale de Lyon. Accessed February 27, 2021. http://www.theses.fr/2013ECDL0015.

MLA Handbook (7^th Edition):

Nironi, Chiara. “Concentration fluctuations of a passive scalar in a turbulent boundary layer : Les fluctuations de concentration d'un scalaire passif dans une couche limite turbulente.” 2013. Web. 27 Feb 2021.

Vancouver:

Nironi C. Concentration fluctuations of a passive scalar in a turbulent boundary layer : Les fluctuations de concentration d'un scalaire passif dans une couche limite turbulente. [Internet] [Doctoral dissertation]. Ecully, Ecole centrale de Lyon; 2013. [cited 2021 Feb 27]. Available from: http://www.theses.fr/2013ECDL0015.

Council of Science Editors:

Nironi C. Concentration fluctuations of a passive scalar in a turbulent boundary layer : Les fluctuations de concentration d'un scalaire passif dans une couche limite turbulente. [Doctoral Dissertation]. Ecully, Ecole centrale de Lyon; 2013. Available from: http://www.theses.fr/2013ECDL0015

Loughborough University

21. Unadkat, Heema. Investigation of turbulence modulation in solid-liquid suspensions using FPIV and micromixing experiments.

Degree: PhD, 2010, Loughborough University

URL: http://hdl.handle.net/2134/6377

► The focus of this thesis is the study of turbulent solid-liquid stirred suspensions, which are involved in many common unit operations in the chemical, pharmaceutical… (more)

▼ The focus of this thesis is the study of turbulent solid-liquid stirred suspensions, which are involved in many common unit operations in the chemical, pharmaceutical and food industries. The studies of two-phase flows present a big challenge to researchers due to the complexity of experiments; hence there is a lack of quantitative solid and liquid hydrodynamic measurements. Therefore, an investigation of turbulence modulation by dispersed particles on the surrounding fluid in stirred vessels has been carried out, via two-phase fluorescent Particle Image Velocimetry (FPIV) and micromixing experiments. The main property of interest has been the local dissipation rate, as well as root-mean-square (rms) velocities and turbulent kinetic energy (TKE) of the fluid. Initially a single-phase PIV study was conducted to investigate the flow field generated by a sawtooth (EkatoMizer) impeller. The purpose of this study was to gain insight into various PIV techniques before moving on to more complex two-phase flows. Subsequently stereo-, highspeed and angle-resolved measurements were obtained. The EkatoMizer formed a good case study as information regarding its hydrodynamics is not readily available in literature, hence knowledge has been extended in this area. An analysis of the mean flow field elucidated the general structure of fluid drawn into the impeller region axially and discharged radially; the latter characterised the impeller stream. The radial rms velocity was considered to represent best the system turbulence, even though the tangential rms velocity was greater close to the blade; however the radial component was more prevalent in the discharge stream. Due to differences in rms velocities, TKE estimates obtained from two and three velocity components deviated, being greater in the latter case. Integral (1-D and 2-D) length scales were overestimated by the quantity W / 2 in the impeller region. Ratios of longitudinal-to-lateral length scales also indicated flow anisotropy (as they deviated from 2:1). The anisotropy tensor showed that the flow was anisotropic close to the blade, and returned to isotropy further away from the impeller. Instantaneous vector plots revealed vortices in the discharge stream, but these were not associated with flow periodicity. Alternatively, the vortex structures were interpreted as low frequency phenomena between 0-200 Hz; macro-instabilities were found to have a high probability of occurrence in the discharge stream. Dissipation is the turbulent property of most interest as it directly influences micromixing processes, and its calculation is also the most difficult to achieve. Its direct determination from definition requires highly resolved data. Alternative methods have been proposed in the literature, namely dimensional analysis, large eddy simulation (LES) analogy and deduction from the TKE balance. All methods were employed using 2-D and 3-D approximations from stereo-PIV data. The LES analogy was deemed to provide the best estimate, since it accounts for three-dimensionality of the…

Subjects/Keywords: 620.106; Multiphase flows; Micromixing; Turbulence; Particle image velocimetry; Phase separation; Stirred tanks; Parallel reactions

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Unadkat, H. (2010). Investigation of turbulence modulation in solid-liquid suspensions using FPIV and micromixing experiments. (Doctoral Dissertation). Loughborough University. Retrieved from http://hdl.handle.net/2134/6377

Chicago Manual of Style (16^th Edition):

Unadkat, Heema. “Investigation of turbulence modulation in solid-liquid suspensions using FPIV and micromixing experiments.” 2010. Doctoral Dissertation, Loughborough University. Accessed February 27, 2021. http://hdl.handle.net/2134/6377.

MLA Handbook (7^th Edition):

Unadkat, Heema. “Investigation of turbulence modulation in solid-liquid suspensions using FPIV and micromixing experiments.” 2010. Web. 27 Feb 2021.

Vancouver:

Unadkat H. Investigation of turbulence modulation in solid-liquid suspensions using FPIV and micromixing experiments. [Internet] [Doctoral dissertation]. Loughborough University; 2010. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2134/6377.

Council of Science Editors:

Unadkat H. Investigation of turbulence modulation in solid-liquid suspensions using FPIV and micromixing experiments. [Doctoral Dissertation]. Loughborough University; 2010. Available from: http://hdl.handle.net/2134/6377

22. Metto, Eve C. Development of microanalytical methods for solving sample limiting biological analysis problems.

Degree: PhD, Department of Chemistry, 2013, Kansas State University

URL: http://hdl.handle.net/2097/15680

► Analytical separations form the bulk of experiments in both research and industry. The choice of separation technique is governed by the characteristics of the analyte… (more)

▼ Analytical separations form the bulk of experiments in both research and industry. The choice of separation technique is governed by the characteristics of the analyte and purpose of separation. Miniaturization of chromatographic techniques enables the separation and purification of small volume samples that are often in limited supply. Capillary electrophoresis and immunoaffinity chromatography are examples of techniques that can be easily miniaturized with minimum loss in separation efficiency. These techniques were used in the experiments presented in this dissertation. Chapter 1 discusses the underlying principles of capillary electrophoresis and immunoaffinity chromatography. In the second chapter, the results from immunoaffinity chromatography experiments that utilized antibody-coated magnetic beads to purify serine proteases and serine protease inhibitors (serpins) from A. gambiae hemolymph are presented and discussed. Serine proteases and serpins play a key role in the insect innate immunity system. Serpins regulate the activity of serine proteases by forming irreversible complexes with the proteases. To identify the proteases that couple to these serpins, protein A magnetic beads were coated with SRPN2 antibody and then incubated with A. gambiae hemolymph. The antibody isolated both the free SRPN2 and the SRPN2-protease complex. The purified proteases were identified by ESI-MS from as few as 25 insects. In Chapter 3, an integrated glass/PDMS hybrid microfluidic device was utilized for the transportation and lysis of cells at a high throughput. Jurkat cells were labeled with 6-CFDA (an internal standard) and DAF-FM (a NO specific fluorophore). Laser-induced fluorescence (LIF) detection was utilized to detect nitric oxide (NO) from single Jurkat cells. The resulting electropherograms were used to study the variation in NO production following stimulation with lipopolysaccharide (LPS). 3 h LPS-stimulation resulted in a two fold increase in NO production in both bulk and single cell analysis. A comparison of bulk and single cell NO measurements were performed and the average NO production in single cells compared well to the increase measured at the bulk cell level. Chapter 4 discusses the preliminary experiments with a T-shaped microfluidic device that exploit the property of poly(dimethylsiloxane) (PDMS) as an electroactive polymer (EAP), to enhance fluid mixing. EAPs deform when placed in an electric field. A thin layer of PDMS was sandwiched between chrome electrodes, positioned on the horizontal arms of the T design, and the electrolyte-filled fluidic channel. A potential difference across the PDMS layer caused it to shrink and stretch, thereby increasing the channel volume. The electrodes were actuated at 180[degrees] out of phase and this caused the fluid stream in the vertical channel to fold and stretch resulting in enhanced contact surface area and shorter diffusion distances of the fluid, thereby improving mixing efficiency. All the experiments presented in this dissertation demonstrate the… Advisors/Committee Members: Christopher T. Culbertson.

Subjects/Keywords: Microfluidics; Immunoaffinity chromatography; Single cell analysis; Micromixing; Nitric oxide; Serpins; Chemistry (0485)

…75 ix Chapter 4 - Rapid and Efficient Micromixing via Actuation of Dielectric Elastomer… …dimethylsiloxane) (PDMS) as a dielectric elastomer is exploited in designing a micromixing…

11 more images…

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APA (6^th Edition):

Metto, E. C. (2013). Development of microanalytical methods for solving sample limiting biological analysis problems. (Doctoral Dissertation). Kansas State University. Retrieved from http://hdl.handle.net/2097/15680

Chicago Manual of Style (16^th Edition):

Metto, Eve C. “Development of microanalytical methods for solving sample limiting biological analysis problems.” 2013. Doctoral Dissertation, Kansas State University. Accessed February 27, 2021. http://hdl.handle.net/2097/15680.

MLA Handbook (7^th Edition):

Metto, Eve C. “Development of microanalytical methods for solving sample limiting biological analysis problems.” 2013. Web. 27 Feb 2021.

Vancouver:

Metto EC. Development of microanalytical methods for solving sample limiting biological analysis problems. [Internet] [Doctoral dissertation]. Kansas State University; 2013. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2097/15680.

Council of Science Editors:

Metto EC. Development of microanalytical methods for solving sample limiting biological analysis problems. [Doctoral Dissertation]. Kansas State University; 2013. Available from: http://hdl.handle.net/2097/15680

23. Kazemi, Amir Sadegh. Development of High-throughput Membrane Filtration Techniques for Biological and Environmental Applications.

Degree: PhD, 2018, McMaster University

URL: http://hdl.handle.net/11375/23404

►

Membrane filtration processes are widely utilized across different industrial sectors for biological and environmental separations. Examples of the former are sterile filtration and protein fractionation… (more)

▼

Membrane filtration processes are widely utilized across different industrial sectors for biological and environmental separations. Examples of the former are sterile filtration and protein fractionation via microfiltration (MF) and ultrafiltration (UF) while drinking water treatment, tertiary treatment of wastewater, water reuse and desalination via MF, UF, nanofiltration (NF) and reverse-osmosis (RO) are examples of the latter. A common misconception is that the performance of membrane separation is solely dependent on the membrane pore size, whereas a multitude of parameters including solution conditions, solute concentration, presence of specific ions, hydrodynamic conditions, membrane structure and surface properties can significantly influence the separation performance and the membrane’s fouling propensity. The conventional approach for studying filtration performance is to use a single lab- or pilot-scale module and perform numerous experiments in a sequential manner which is both time-consuming and requires large amounts of material. Alternatively, high-throughput (HT) techniques, defined as the miniaturized version of conventional unit operations which allow for multiple experiments to be run in parallel and require a small amount of sample, can be employed. There is a growing interest in the use of HT techniques to speed up the testing and optimization of membrane-based separations. In this work, different HT screening approaches are developed and utilized for the evaluation and optimization of filtration performance using flat-sheet and hollow-fiber (HF) membranes used in biological and environmental separations. The effects of various process factors were evaluated on the separation of different biomolecules by combining a HT filtration method using flat-sheet UF membranes and design-of-experiments methods. Additionally, a novel HT platform was introduced for multi-modal (constant transmembrane pressure vs. constant flux) testing of flat-sheet membranes used in bio-separations. Furthermore, the first-ever HT modules for parallel testing of HF membranes were developed for rapid fouling tests as well as extended filtration evaluation experiments. The usefulness of the modules was demonstrated by evaluating the filtration performance of different foulants under various operating conditions as well as running surface modification experiments. The techniques described herein can be employed for rapid determination of the optimal combination of conditions that result in the best filtration performance for different membrane separation applications and thus eliminate the need to perform numerous conventional lab-scale tests. Overall, more than 250 filtration tests and 350 hydraulic permeability measurements were performed and analyzed using the HT platforms developed in this thesis.

Thesis

Doctor of Philosophy (PhD)

Membrane filtration is widely used as a key separation process in different industries. For example, microfiltration (MF) and ultrafiltration (UF) are used for sterilization and…

Advisors/Committee Members: Latulippe, David, Chemical Engineering.

Subjects/Keywords: Membrane filtration; Ultrafiltration; Downstream bio-processing; High-throughput (HT) testing; Wastewater treatment; Hollow-fiber membranes; Humic acids; High-throughput filtration; Design-of-experiments (DOE); Process optimization; Microscale filtration; Microfluidic flow control system; Stirred well filtration; SWF; High-throughput hollow-fiber module; HT-HF; Constant TMP; Constant flux; Multi-modal filtration; Bioseparation; MMFC; Microscale parallel-structured, cross-flow filtration; MS-PS-CFF; PEG; Dextran; FITC-Dextran; BSA; DNA; IgG; α-lactalbumin; Biomolecule separation; Module hydrodynamics; Concentration polarization; Membrane fouling; Micromixing; Omega™ membrane; Microscale processing; Fouling test; PVDF membrane; Surface modification; Polydopamine; Membrane cleaning; Membrane backwashing; Sodium alginate; Polyethersulfone; PES; Hydraulic permeability; Membrane permeability; ZeeWeed® membrane; Filtration ionic strength; Filtration pH; Solution conditions; Water treatment; Environmental separations; Biological separations

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APA (6^th Edition):

Kazemi, A. S. (2018). Development of High-throughput Membrane Filtration Techniques for Biological and Environmental Applications. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/23404

Chicago Manual of Style (16^th Edition):

Kazemi, Amir Sadegh. “Development of High-throughput Membrane Filtration Techniques for Biological and Environmental Applications.” 2018. Doctoral Dissertation, McMaster University. Accessed February 27, 2021. http://hdl.handle.net/11375/23404.

MLA Handbook (7^th Edition):

Kazemi, Amir Sadegh. “Development of High-throughput Membrane Filtration Techniques for Biological and Environmental Applications.” 2018. Web. 27 Feb 2021.

Vancouver:

Kazemi AS. Development of High-throughput Membrane Filtration Techniques for Biological and Environmental Applications. [Internet] [Doctoral dissertation]. McMaster University; 2018. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/11375/23404.

Council of Science Editors:

Kazemi AS. Development of High-throughput Membrane Filtration Techniques for Biological and Environmental Applications. [Doctoral Dissertation]. McMaster University; 2018. Available from: http://hdl.handle.net/11375/23404

Open Access Theses and Dissertations