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You searched for subject:(Microcrystal Test). Showing records 1 – 3 of 3 total matches.

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University of Illinois – Chicago

1. Davila, Jacqueline. Development of a Microcrystal Test For The Detection of Psilocin.

Degree: 2019, University of Illinois – Chicago

A microcrystal test is a chemical reaction at a microscopic level, which was developed in the 1800’s as a way to identify unknown alkaloids. Recently this type of testing has been experiencing a revival within forensic science due in part to the rise in drug cases being brought to forensic laboratories. The tests in its most basic form require only the use of a polarized light microscope, a small amount of sample material and a chemical reagent to facilitate a chemical reaction. Microcrystal tests are beneficial, as their analysis is relativity short requiring little to no preparation of the samples before analysis. There are microcrystal tests for many of the common street drugs, however, these tests were developed decades ago. Therefore a few of the reagents used to identify some of these common street drugs, such as trinitrobenzoic acid used for the identification of psilocin in “magic” mushrooms, are no longer commercially available, making it difficult, if not impossible, for laboratories to use these tests. Therefore the purpose of this thesis was to develop a new microcrystal test to detect the presence of psilocin, using the optical characteristics of the precipitated crystals. Psilocybin mushrooms are commonly referred to as “magic” mushrooms and contain the hallucinogen compounds psilocybin and psilocin. However psilocybin is unstable and rapidly dephosphorylates into psilocin, the main active and stable metabolite responsible for the hallucinogenic effects of the mushrooms. Due to psilocybin’s unstable nature the techniques used to identify hallucinogenic mushrooms, look for psilocin within the sample. These mushrooms are one of the most common type of hallucinogen seen today, though their use as a hallucinogen dates back thousands of years. With the rise in popularity of micro-dosing among young professionals, a new microcrystal tests using a readily available reagent would be beneficial. The creation of a new microcrystal test for psilocin was developed. The tests utilized either picric acid or bromine-HBr as a reagent to formed precipitated crystals. With picric acid the formation of plates and rosettes of plates signified the presence of psilocin and with bromine-HBr, psilocin was identified by the precipitation of rod shaped crystals. Advisors/Committee Members: Larsen, Albert K (advisor), Hall, Ashley (committee member), Sparenga, Sebastian (committee member), Waller, Donald P (committee member), Larsen, Albert K (chair).

Subjects/Keywords: microcrystal test; psilocin; magic mushrooms

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Davila, J. (2019). Development of a Microcrystal Test For The Detection of Psilocin. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/23856

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Davila, Jacqueline. “Development of a Microcrystal Test For The Detection of Psilocin.” 2019. Thesis, University of Illinois – Chicago. Accessed August 06, 2020. http://hdl.handle.net/10027/23856.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Davila, Jacqueline. “Development of a Microcrystal Test For The Detection of Psilocin.” 2019. Web. 06 Aug 2020.

Vancouver:

Davila J. Development of a Microcrystal Test For The Detection of Psilocin. [Internet] [Thesis]. University of Illinois – Chicago; 2019. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/10027/23856.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Davila J. Development of a Microcrystal Test For The Detection of Psilocin. [Thesis]. University of Illinois – Chicago; 2019. Available from: http://hdl.handle.net/10027/23856

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of Illinois – Chicago

2. Jones, Shan Mei. Development of Microcrystal Tests for Butylone, Ethylone, and Methylone Detection.

Degree: 2017, University of Illinois – Chicago

Microcrystal tests are a microchemistry technique developed in the 1800’s. Recently, they have been used more frequently in forensic science to help identify drugs of abuse, such as amphetamine and cocaine. Microcrystal tests are advantageous due to relatively short analysis time, small sample quantity used during test, and little to no sample preparation. Since microcrystal tests have only recently started to be used in forensic science again, validated methods are required, before they can be used. While microcrystal tests have been developed for many common drugs of abuse, newer drugs of abuse do not have validated tests, among which are the synthetic cathinones. Therefore, the purpose of this thesis was to develop microcrystal tests that could detect butylone, ethylone, and methylone, through optical characteristics of precipitated crystals. Synthetic cathinones, street name “Bath Salts”, are newer drugs of abuse that are man-made compounds similar to cathinone. They have become more prominent on the illegal drug market since 2010. Cathinone is a naturally occurring compound found in khat (Catha edulis) leaves. Since cathinone, and subsequently synthetic cathinones, is a stimulant, increased euphoria, alertness, sexual arousal, sociability, concentration, and motivation can occur upon administration. Since 2010, synthetic cathinones have become more prominent on the illegal drug market; signifying, validated microcrystal tests could be beneficial. Microcrystal tests were successfully developed to detect butylone, ethylone, and methylone individually and in the presence of adulterants. Each test utilized either pricrolonic or picric acid as the reagent. All three drugs were identified by precipitation of rosettes. Methylone formed rosettes with both reagents. All four crystals are distinguishable either by reagent used or optical properties. Also, attenuated total reflectance-infrared spectroscopy was performed on each drug and butylone and methylone crystals precipitated from picrolonic acid, for reference purposes. These tests are unique since no other drug is known to produce the same crystals and optical characteristics with these reagents; thus, they are good options for use in forensic science. Advisors/Committee Members: Larsen, Karl (advisor), Hall, Ashley (committee member), Schlemmer, Francis (committee member), King, Meggan (committee member), Larsen, Karl (chair).

Subjects/Keywords: Microcrystal; Microcrystal Test; Butylone; Ethylone; Methylone; Cathinone; Synthetic Cathinone; Bath Salts; Picrolonic Acid; Picric Acid; Microscopy; PLM; ATR

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Jones, S. M. (2017). Development of Microcrystal Tests for Butylone, Ethylone, and Methylone Detection. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/22068

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Jones, Shan Mei. “Development of Microcrystal Tests for Butylone, Ethylone, and Methylone Detection.” 2017. Thesis, University of Illinois – Chicago. Accessed August 06, 2020. http://hdl.handle.net/10027/22068.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Jones, Shan Mei. “Development of Microcrystal Tests for Butylone, Ethylone, and Methylone Detection.” 2017. Web. 06 Aug 2020.

Vancouver:

Jones SM. Development of Microcrystal Tests for Butylone, Ethylone, and Methylone Detection. [Internet] [Thesis]. University of Illinois – Chicago; 2017. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/10027/22068.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jones SM. Development of Microcrystal Tests for Butylone, Ethylone, and Methylone Detection. [Thesis]. University of Illinois – Chicago; 2017. Available from: http://hdl.handle.net/10027/22068

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Silletti, Danielle K. Development of a Microcrystal Test for the Detection of Clonazepam.

Degree: 2014, University of Illinois – Chicago

Microcrystal tests are chemical microscopy techniques that date back to the 1800s. Recently they have been used as an analytical technique for distinguishing certain classes of drugs in the forensic sciences. Some advantages of microcrystal tests are they’re relatively inexpensive, fairly simple to conduct, and use very little drug sample. There are disadvantages to this technique, however, including the need for comparison standards, and a clean sample. While some drugs, such as cocaine and heroin, have well validated microcrystal tests, other classes of drugs, i.e. the benzodiazepines have not been extensively studied for this purpose. The goal of this project, therefore, was to optically characterize and develop a microcrystal test that could be used to detect clonazepam. Clonazepam is a benzodiazepine drug is sold under the trade name Klonopin®. It is known for its sedative-hypnotic properties and has therapeutic uses as an anticonvulsant and anxiolytic. Benzodiazepines have been abused for these sedative effects, but are more popularly known for their use in drug-facilitated sexual assaults. In the past decade emergency department visits involving the abuse and misuse of benzodiazepines have increased, indicating the benefit of validated microcrystal tests for their detection. A microcrystal test was successfully developed that is able to detect clonazepam in its pharmaceutical preparations at all of its therapeutic dosages. The test involves the addition of acetone and a 10% platinum chloride solution to microgram quantities of clonazepam. The presence of clonazepam is indicated by the formation of rosettes made of colorless, blunt-ended rods. No other drug is known to exhibit the same reaction with these reagents making the test a good candidate for use in forensic lab settings. Advisors/Committee Members: Larsen, Albert K. (advisor), Laughlin, Gary (advisor), Laughlin, Gary (committee member), Negrusz, Adam (committee member).

Subjects/Keywords: Microcrystal test; clonazepam; forensic science

microcrystal tests for their detection. A microcrystal test was developed that is able to detect… …formation when combined with the drugs in a microcrystal test. He used the same method, a hanging… …drop test, for all of his microcrystal tests so that the test drops wouldn’t evaporate over… …benzodiazepines though microcrystal tests. Haynes used the same 5 direct test method for all of… …successful microcrystal test trials. The results of this study as they compare to the results of… 

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Silletti, D. K. (2014). Development of a Microcrystal Test for the Detection of Clonazepam. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/11269

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Silletti, Danielle K. “Development of a Microcrystal Test for the Detection of Clonazepam.” 2014. Thesis, University of Illinois – Chicago. Accessed August 06, 2020. http://hdl.handle.net/10027/11269.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Silletti, Danielle K. “Development of a Microcrystal Test for the Detection of Clonazepam.” 2014. Web. 06 Aug 2020.

Vancouver:

Silletti DK. Development of a Microcrystal Test for the Detection of Clonazepam. [Internet] [Thesis]. University of Illinois – Chicago; 2014. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/10027/11269.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Silletti DK. Development of a Microcrystal Test for the Detection of Clonazepam. [Thesis]. University of Illinois – Chicago; 2014. Available from: http://hdl.handle.net/10027/11269

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.