subject:(Medicine AND Health Sciences)

1. Pangrazzi, Elizabeth. The Rural Provider's Perspective| Conversations With Patients About Mental Health.

Degree: 2017, Union Institute and University

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=10624346

► The rural primary care provider is likely to treat patients with mental health issues in rural populations due to lack of mental health providers,… (more)

Subjects/Keywords: Mental health; Medicine; Health sciences

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APA (6^th Edition):

Pangrazzi, E. (2017). The Rural Provider's Perspective| Conversations With Patients About Mental Health. (Thesis). Union Institute and University. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=10624346

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pangrazzi, Elizabeth. “The Rural Provider's Perspective| Conversations With Patients About Mental Health.” 2017. Thesis, Union Institute and University. Accessed February 27, 2020. http://pqdtopen.proquest.com/#viewpdf?dispub=10624346.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pangrazzi, Elizabeth. “The Rural Provider's Perspective| Conversations With Patients About Mental Health.” 2017. Web. 27 Feb 2020.

Vancouver:

Pangrazzi E. The Rural Provider's Perspective| Conversations With Patients About Mental Health. [Internet] [Thesis]. Union Institute and University; 2017. [cited 2020 Feb 27]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10624346.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pangrazzi E. The Rural Provider's Perspective| Conversations With Patients About Mental Health. [Thesis]. Union Institute and University; 2017. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10624346

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

2. MacLeod, Natalie T. A controlled cluster randomized pilot study of the effect of a new smoking cessation management module on rates of initiation and continuation of smoking counselling in Ontario primary care practices using P-PROMPT Chronic Disease Management System (CDMS).

Degree: MS, 2010, McMaster University

URL: http://hdl.handle.net/11375/12299

►

Multi-faceted interventions that include some form of a clinical information system have been shown to improve primary care physicians' management of chronic diseases. The… (more)

▼

Multi-faceted interventions that include some form of a clinical information system have been shown to improve primary care physicians' management of chronic diseases. The objective of this pilot study was to assess the feasibility of a cluster randomized controlled trial of a multi-faceted intervention, which includes a clinical information system, to improve the management of the chronic disease of tobacco use by physicians. Feasibility was assessed with respect to the use of a measurement tool (Smoking Status Identification Card) and use of a new smoking cessation management module in the clinical information system. Letters of invitation were sent out to the 65 primary care physicians (in 38 primary care practices) who were subscribed to the web-based clinical information system (P-PROMPT CDMS). Five physicians from 5 primary care practices agree.d to participate, who were stratified and then randomized to the intervention (2 primary care practices) or control group (3 primary care practices). Following the 12-week study period, SSIC completion reached the 90% threshold success criterion in 2 of the 5 primary care practices (one each from the intervention and control group). The intervention group demonstrated basic use of the new smoking cessation management module that reached 21.9% and 19.0% in each of the respective practices, which was below the 30% threshold success criterion. A preliminary evaluation of physician delivery of smoking cessation counselling demonstrated a trend to a higher percentage of Ministry of Health and Long-Term Care (MOHLTC) physician service billing codes submitted among the physicians in the intervention group, which may be indicative of greater smoking cessation counselling. It is concluded that a randomized controlled trial to test a multi-faceted intervention is not feasible with the current study design. Significant modifications to the current study design are required that can potentially be tested prior to progression to a larger trial.

Master of Science (MS)

Advisors/Committee Members: Sebaldt, Rolf J., Health Research Methodology.

Subjects/Keywords: Health Research Methodology; Medicine and Health Sciences; Medicine and Health Sciences

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APA (6^th Edition):

MacLeod, N. T. (2010). A controlled cluster randomized pilot study of the effect of a new smoking cessation management module on rates of initiation and continuation of smoking counselling in Ontario primary care practices using P-PROMPT Chronic Disease Management System (CDMS). (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/12299

Chicago Manual of Style (16^th Edition):

MacLeod, Natalie T. “A controlled cluster randomized pilot study of the effect of a new smoking cessation management module on rates of initiation and continuation of smoking counselling in Ontario primary care practices using P-PROMPT Chronic Disease Management System (CDMS).” 2010. Masters Thesis, McMaster University. Accessed February 27, 2020. http://hdl.handle.net/11375/12299.

MLA Handbook (7^th Edition):

MacLeod, Natalie T. “A controlled cluster randomized pilot study of the effect of a new smoking cessation management module on rates of initiation and continuation of smoking counselling in Ontario primary care practices using P-PROMPT Chronic Disease Management System (CDMS).” 2010. Web. 27 Feb 2020.

Vancouver:

MacLeod NT. A controlled cluster randomized pilot study of the effect of a new smoking cessation management module on rates of initiation and continuation of smoking counselling in Ontario primary care practices using P-PROMPT Chronic Disease Management System (CDMS). [Internet] [Masters thesis]. McMaster University; 2010. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/11375/12299.

Council of Science Editors:

MacLeod NT. A controlled cluster randomized pilot study of the effect of a new smoking cessation management module on rates of initiation and continuation of smoking counselling in Ontario primary care practices using P-PROMPT Chronic Disease Management System (CDMS). [Masters Thesis]. McMaster University; 2010. Available from: http://hdl.handle.net/11375/12299

3. Gottlieb, Eric Raphael. Humoral Immune Responses to a Malaria Vaccine Candidate| Towards a Correlate of Vaccine-Induced Protection.

Degree: 2012, University of Maryland, Baltimore

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=1512511

► Introduction: Identifying immune correlates of protection is a priority for malaria vaccine research. A successful pediatric Phase 2 clinical trial in Mali of FMP2.1/AS02_A,… (more)

▼ Introduction: Identifying immune correlates of protection is a priority for malaria vaccine research. A successful pediatric Phase 2 clinical trial in Mali of FMP2.1/AS02_A, a recombinant apical membrane antigen 1 (AMA1)-based vaccine candidate, provided a source of serum samples from subjects who may have developed vaccine-induced, strain-specific protective immunity to clinical malaria illness. We studied IgG subclass and avidity patterns of antibodies to the malaria protein AMA1 in a subset of participants, with the objective of identifying immune responses that may be associated with protection against malaria. We hypothesized that the AMA1 vaccine candidate would induce production of cytophilic antibody subclasses IgG1 and IgG3, as well as overall IgG avidity maturation. Methods: Titers of IgG1, IgG2, IgG3, and IgG4, as well as avidity of antibodies to AMA1, were determined by ELISA for ten AMA1 vaccine recipients and ten control subjects who had been randomized to receive a rabies vaccine in this double-blind trial at days 0, 90, and 150 after the first of three vaccinations. To identify statistically significant differences between the groups, responses in vaccine recipients were evaluated longitudinally and compared with responses in control subjects. Results: IgG1, IgG2, IgG3, and IgG4 were induced more strongly in vaccine recipients than in control subjects. Additionally, vaccine recipients had higher ratios of cytophilic to non-cytophilic antibodies than control subjects. Avidity indices were not significantly different between the two groups at the three time points tested, and there were no significant differences in avidity between time points in either group. Conclusion: Contrary to our hypothesis, both cytophilic and non-cytophilic antibodies were induced by the FMP2.1/AS02A vaccine candidate and immunization did not appear to stimulate avidity maturation. Therefore, IgG1, IgG2, IgG3, and IgG4 titers are candidate variables for a humoral immune correlate of vaccine-induced protection. These results are among the first reports of the subclasses and avidity of antibodies produced in response to a malaria vaccine candidate with allele-specific protective efficacy.

Subjects/Keywords: Health Sciences; Medicine and Surgery

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APA (6^th Edition):

Gottlieb, E. R. (2012). Humoral Immune Responses to a Malaria Vaccine Candidate| Towards a Correlate of Vaccine-Induced Protection. (Thesis). University of Maryland, Baltimore. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=1512511

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gottlieb, Eric Raphael. “Humoral Immune Responses to a Malaria Vaccine Candidate| Towards a Correlate of Vaccine-Induced Protection.” 2012. Thesis, University of Maryland, Baltimore. Accessed February 27, 2020. http://pqdtopen.proquest.com/#viewpdf?dispub=1512511.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gottlieb, Eric Raphael. “Humoral Immune Responses to a Malaria Vaccine Candidate| Towards a Correlate of Vaccine-Induced Protection.” 2012. Web. 27 Feb 2020.

Vancouver:

Gottlieb ER. Humoral Immune Responses to a Malaria Vaccine Candidate| Towards a Correlate of Vaccine-Induced Protection. [Internet] [Thesis]. University of Maryland, Baltimore; 2012. [cited 2020 Feb 27]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=1512511.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gottlieb ER. Humoral Immune Responses to a Malaria Vaccine Candidate| Towards a Correlate of Vaccine-Induced Protection. [Thesis]. University of Maryland, Baltimore; 2012. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=1512511

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. DeRosa, Megan Sullivan. Golden Threads| Shared Themes in Holistic Health and Healing Modalities.

Degree: 2013, Prescott College

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=1530859

► There is growing popularity and widespread use of holistic health and healing modalities, which emphasize a mind-body-spirit approach to supporting or restoring well-being and… (more)

Subjects/Keywords: Health Sciences, Alternative Medicine; Spirituality

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APA (6^th Edition):

DeRosa, M. S. (2013). Golden Threads| Shared Themes in Holistic Health and Healing Modalities. (Thesis). Prescott College. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=1530859

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

DeRosa, Megan Sullivan. “Golden Threads| Shared Themes in Holistic Health and Healing Modalities.” 2013. Thesis, Prescott College. Accessed February 27, 2020. http://pqdtopen.proquest.com/#viewpdf?dispub=1530859.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

DeRosa, Megan Sullivan. “Golden Threads| Shared Themes in Holistic Health and Healing Modalities.” 2013. Web. 27 Feb 2020.

Vancouver:

DeRosa MS. Golden Threads| Shared Themes in Holistic Health and Healing Modalities. [Internet] [Thesis]. Prescott College; 2013. [cited 2020 Feb 27]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=1530859.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

DeRosa MS. Golden Threads| Shared Themes in Holistic Health and Healing Modalities. [Thesis]. Prescott College; 2013. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=1530859

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

5. Oliver, Brant J. Modifiable Factor Relationships with Biopsychosocial Disability in Multiple Sclerosis.

Degree: 2017, Dartmouth College

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=10184281

► Problem Statement: Multiple sclerosis (MS) is a chronic disease of the central nervous system and is among the most common neurological disorders in adults.… (more)

▼ Problem Statement: Multiple sclerosis (MS) is a chronic disease of the central nervous system and is among the most common neurological disorders in adults. MS causes significant disability and has no cure. Neurological disease severity is thought to contribute to disability but may not be the main determinant. Individual and environmental factors may modify the relationship between disease severity and disability or directly influence it. Research simultaneously relating these factors in MS has not yet been conducted. Methods: Participants completed an internet questionnaire and a telephone-administered cognitive recall performance task. Clinical data were extracted from a data registry maintained by the Multiple Sclerosis Center at Dartmouth-Hitchcock Medical Center (DHMC) in Lebanon, New Hampshire. Correlation and multiple regression analyses were conducted to determine the relationships between disease severity, individual factors, environmental factors and biopsychosocial disability (BPSD). Results: One hundred-eighty (180) adults with relapsing forms of MS participated in the study, representing approximately 15% of the total MS patient population followed by the database registry at DHMC. The study population was 76% female, had 14.6 years of education, a mean annual income of $35,000, was 75% relapsing-remitting MS (RRMS), had a mean EDSS of 2.4, and a mean ARR of 0.21. In multiple regression analyses, disease severity explained 3%, demographic variables 6%, individual factors 69%, and environmental factors 64% of the variance in BPSD, respectively. The final model incorporating disease severity, individual factors, and environmental factors explained 74% of the variance in BPSD. Depression and environmental status demonstrated the strongest associations with BPSD. Conclusions: Neuropsychiatric status, bowel and bladder function, self-efficacy, social support, and environmental status are key factors associated with BPSD. These factors are modifiable by medical, psychosocial, and/or case management interventions. This study has three major limitations: (1) inability to predict causality or directionality of associations; (2) susceptibility to self-report bias; and (3) susceptibility to temporal bias. This study provides a basis for continued research on biopsychosocial disability reduction and to related healthcare quality improvement, shared decision making, and health policy initiatives.

Subjects/Keywords: Medicine; Health sciences; Nursing

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APA (6^th Edition):

Oliver, B. J. (2017). Modifiable Factor Relationships with Biopsychosocial Disability in Multiple Sclerosis. (Thesis). Dartmouth College. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=10184281

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Oliver, Brant J. “Modifiable Factor Relationships with Biopsychosocial Disability in Multiple Sclerosis.” 2017. Thesis, Dartmouth College. Accessed February 27, 2020. http://pqdtopen.proquest.com/#viewpdf?dispub=10184281.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Oliver, Brant J. “Modifiable Factor Relationships with Biopsychosocial Disability in Multiple Sclerosis.” 2017. Web. 27 Feb 2020.

Vancouver:

Oliver BJ. Modifiable Factor Relationships with Biopsychosocial Disability in Multiple Sclerosis. [Internet] [Thesis]. Dartmouth College; 2017. [cited 2020 Feb 27]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10184281.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Oliver BJ. Modifiable Factor Relationships with Biopsychosocial Disability in Multiple Sclerosis. [Thesis]. Dartmouth College; 2017. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10184281

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Nyznyk, Julia. Decreasing Medication Errors Through the Reduction of Avoidable Interruptions.

Degree: MSN, 2014, University of San Francisco

URL: https://repository.usfca.edu/capstone/66

► In recent years, the media has been rife with stories of medical mistakes in hospitals or other health care settings that lead to patient… (more)

Subjects/Keywords: Medicine and Health Sciences

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APA (6^th Edition):

Nyznyk, J. (2014). Decreasing Medication Errors Through the Reduction of Avoidable Interruptions. (Thesis). University of San Francisco. Retrieved from https://repository.usfca.edu/capstone/66

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nyznyk, Julia. “Decreasing Medication Errors Through the Reduction of Avoidable Interruptions.” 2014. Thesis, University of San Francisco. Accessed February 27, 2020. https://repository.usfca.edu/capstone/66.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nyznyk, Julia. “Decreasing Medication Errors Through the Reduction of Avoidable Interruptions.” 2014. Web. 27 Feb 2020.

Vancouver:

Nyznyk J. Decreasing Medication Errors Through the Reduction of Avoidable Interruptions. [Internet] [Thesis]. University of San Francisco; 2014. [cited 2020 Feb 27]. Available from: https://repository.usfca.edu/capstone/66.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nyznyk J. Decreasing Medication Errors Through the Reduction of Avoidable Interruptions. [Thesis]. University of San Francisco; 2014. Available from: https://repository.usfca.edu/capstone/66

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

7. Singh, Gagandeep. Reduce the Rooming Time.

Degree: MSN, 2016, University of San Francisco

URL: https://repository.usfca.edu/capstone/285

► The aim of the project Reducing the Rooming Time by the Medical Assistant is to reduce the rooming time from thirteen minutes to ten… (more)

Subjects/Keywords: Medicine and Health Sciences

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APA (6^th Edition):

Singh, G. (2016). Reduce the Rooming Time. (Thesis). University of San Francisco. Retrieved from https://repository.usfca.edu/capstone/285

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Singh, Gagandeep. “Reduce the Rooming Time.” 2016. Thesis, University of San Francisco. Accessed February 27, 2020. https://repository.usfca.edu/capstone/285.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Singh, Gagandeep. “Reduce the Rooming Time.” 2016. Web. 27 Feb 2020.

Vancouver:

Singh G. Reduce the Rooming Time. [Internet] [Thesis]. University of San Francisco; 2016. [cited 2020 Feb 27]. Available from: https://repository.usfca.edu/capstone/285.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Singh G. Reduce the Rooming Time. [Thesis]. University of San Francisco; 2016. Available from: https://repository.usfca.edu/capstone/285

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Balzaretti, Carlee Y.S. Development of a Toolkit to Enhance Nursing Education of Veteran Health Concerns.

Degree: DNP, Nursing, 2016, University of San Francisco

URL: https://repository.usfca.edu/dnp/88

► <h1>Abstract</h1> U.S. Veterans are a vulnerable patient population, more prone to health disparities as compared to the general population. There are 21.8 million Veterans currently… (more)

Subjects/Keywords: Medicine and Health Sciences; Nursing

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APA (6^th Edition):

Balzaretti, C. Y. S. (2016). Development of a Toolkit to Enhance Nursing Education of Veteran Health Concerns. (Thesis). University of San Francisco. Retrieved from https://repository.usfca.edu/dnp/88

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Balzaretti, Carlee Y S. “Development of a Toolkit to Enhance Nursing Education of Veteran Health Concerns.” 2016. Thesis, University of San Francisco. Accessed February 27, 2020. https://repository.usfca.edu/dnp/88.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Balzaretti, Carlee Y S. “Development of a Toolkit to Enhance Nursing Education of Veteran Health Concerns.” 2016. Web. 27 Feb 2020.

Vancouver:

Balzaretti CYS. Development of a Toolkit to Enhance Nursing Education of Veteran Health Concerns. [Internet] [Thesis]. University of San Francisco; 2016. [cited 2020 Feb 27]. Available from: https://repository.usfca.edu/dnp/88.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Balzaretti CYS. Development of a Toolkit to Enhance Nursing Education of Veteran Health Concerns. [Thesis]. University of San Francisco; 2016. Available from: https://repository.usfca.edu/dnp/88

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

9. Saini, Ritu. Understanding and Prevention of Catheter Associated Urinary Tract Infections (CAUTIs).

Degree: MSN, 2018, University of San Francisco

URL: https://repository.usfca.edu/capstone/740

► Abstract The project goal is to reduce and eliminate CAUTI occurrences on the med-surgical unit by increasing staff knowledge on CAUTIs and applying the… (more)

▼ Abstract The project goal is to reduce and eliminate CAUTI occurrences on the med-surgical unit by increasing staff knowledge on CAUTIs and applying the ANA CAUTI prevention tool to improve patient outcomes. The project objectives are (1) enhanced staff knowledge about CAUTIs, (2) staff adherence to the implemented the ANA CAUTI prevention tool, and (3) maintained CAUTI rate below benchmark. The CNL role in the project is to function as an educator and outcomes manager, which serves as the foundation for the project. The department consists of a 34-bed med-surgical unit with the adult patient population mix of oncology, surgical, and cardiac patients. The unit currently utilizes the ANA CAUTI Prevention Tool; however, the rate of CAUTIs continues to increase. The current CAUTI rate for the medical-surgical unit is 1.52 for year 2017 which is above the national benchmark through National Healthcare Safety Network (NHSN). The project goal is to decrease or eliminate CAUTI rate on the unit by 54% for 2018 to bring the rate below the benchmark. The risk factors from root-case, stakeholders and SWOT analysis are categorized into four categories such as human factors, environmental factors, administrative factors and material factors. The project status is in progress. The evaluation plan includes data collection, data analysis, and data comparison. The CAUTI incidences will be measured and collected by infection control daily audit tool explicitly created to CAUTIs. The infection control nurse will be responsible for obtaining this information. Data analysis includes Catheter days, indications, and compliance with ANA tool will be measured through chart review by CAUTI task force and infection control daily audit. The risk analysis department will compare the data to evaluate the quarterly trend and address barriers. The data will help evaluate the reduction in CAUTI rate and staff compliance with ANA CAUTI prevention tool. The project will be sustained through (1) stakeholders’ support, (2) CAUTI task force involvement, (3) by using ANA CAUTI prevention tool appropriately, (4) providing continuous education support, (5) address barriers and challenges and (6) staff recognition. The frontline nursing staff can make the most difference through sound knowledge of CAUTIs, current practice guidelines, and ANA prevention tool.

Subjects/Keywords: Medicine and Health Sciences

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APA (6^th Edition):

Saini, R. (2018). Understanding and Prevention of Catheter Associated Urinary Tract Infections (CAUTIs). (Thesis). University of San Francisco. Retrieved from https://repository.usfca.edu/capstone/740

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Saini, Ritu. “Understanding and Prevention of Catheter Associated Urinary Tract Infections (CAUTIs).” 2018. Thesis, University of San Francisco. Accessed February 27, 2020. https://repository.usfca.edu/capstone/740.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Saini, Ritu. “Understanding and Prevention of Catheter Associated Urinary Tract Infections (CAUTIs).” 2018. Web. 27 Feb 2020.

Vancouver:

Saini R. Understanding and Prevention of Catheter Associated Urinary Tract Infections (CAUTIs). [Internet] [Thesis]. University of San Francisco; 2018. [cited 2020 Feb 27]. Available from: https://repository.usfca.edu/capstone/740.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Saini R. Understanding and Prevention of Catheter Associated Urinary Tract Infections (CAUTIs). [Thesis]. University of San Francisco; 2018. Available from: https://repository.usfca.edu/capstone/740

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas Medical Center

10. Khalili, Jahan. ROLES FOR BRAF KINASE ACTIVATING MUTATIONS IN MELANOMA: MICROENVIRONMENTAL IMMUNOSUPPRESSION.

Degree: PhD, 2011, Texas Medical Center

URL: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/213

► The BRAF oncogene demonstrates a characteristic mutation (V600E) in a significant fraction of cutaneous melanomas, leading to constitutive activation of the MAP kinase pathway.… (more)

Subjects/Keywords: Melanoma; Medicine and Health Sciences

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APA (6^th Edition):

Khalili, J. (2011). ROLES FOR BRAF KINASE ACTIVATING MUTATIONS IN MELANOMA: MICROENVIRONMENTAL IMMUNOSUPPRESSION. (Doctoral Dissertation). Texas Medical Center. Retrieved from http://digitalcommons.library.tmc.edu/utgsbs_dissertations/213

Chicago Manual of Style (16^th Edition):

Khalili, Jahan. “ROLES FOR BRAF KINASE ACTIVATING MUTATIONS IN MELANOMA: MICROENVIRONMENTAL IMMUNOSUPPRESSION.” 2011. Doctoral Dissertation, Texas Medical Center. Accessed February 27, 2020. http://digitalcommons.library.tmc.edu/utgsbs_dissertations/213.

MLA Handbook (7^th Edition):

Khalili, Jahan. “ROLES FOR BRAF KINASE ACTIVATING MUTATIONS IN MELANOMA: MICROENVIRONMENTAL IMMUNOSUPPRESSION.” 2011. Web. 27 Feb 2020.

Vancouver:

Khalili J. ROLES FOR BRAF KINASE ACTIVATING MUTATIONS IN MELANOMA: MICROENVIRONMENTAL IMMUNOSUPPRESSION. [Internet] [Doctoral dissertation]. Texas Medical Center; 2011. [cited 2020 Feb 27]. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/213.

Council of Science Editors:

Khalili J. ROLES FOR BRAF KINASE ACTIVATING MUTATIONS IN MELANOMA: MICROENVIRONMENTAL IMMUNOSUPPRESSION. [Doctoral Dissertation]. Texas Medical Center; 2011. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/213

Texas Medical Center

11. Rodriguez-Cruz, Tania G. THE CYTOPLASMIC TAIL OF MHC CLASS I MOLECULES PLAYS A CRITICAL ROLE IN DENDRITIC CELL-INDUCED T CELL IMMUNITY.

Degree: PhD, 2011, Texas Medical Center

URL: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/243

► The presentation of MHC class I (MHC-I)/peptide complexes by dendritic cells (DCs) is critical for the maintenance of central tolerance to self and for… (more)

▼ The presentation of MHC class I (MHC-I)/peptide complexes by dendritic cells (DCs) is critical for the maintenance of central tolerance to self and for the regulation of cytotoxic T lymphocytes (CTL)-mediated adaptive immune responses against pathogens and cancer cells. Interestingly, several findings have suggested that the cytoplasmic tail of MHC class I plays a functional role in the regulation of CTL immune responses. For example, our previous studies demonstrated that exon 7-deleted MHC-I molecules not only showed extended DC cell surface half-lives but also induced significantly increased CTL responses to viral challange invivo. Although exon 7-deleted variant of MHC-I does not occur naturally in humans, the animal studies prompted us to examine whether exon 7-deleted MHC-I molecules could generate augmented CTL responses in a therapeutic DC-based vaccine setting. To examine the stimulatory capacity of exon 7-deleted MHC-I molecules, we generated a lentivirus-mediated gene transfer system to induce the expression of different MHC-I cytoplasmic tail isoforms in both mouse and human DCs. These DCs were then used as vaccines in a melanoma mouse tumor model and in a human invitro co-culture system. In this thesis, we show that DCs expressing exon 7-deleted MHC-I molecules, stimulated remarkably higher levels of T-cell cytokine production and significantly increased the proliferation of meanoma-specific (Pmel-1) T cells compared with DCs expressing wild type MHC-I. We also demonstrate that, in combination with adoptive transfer of Pmel-1 T-cell, DCs expressing exon 7-deleted Db molecules induced greater anti-tumor responses against established B16 melanoma tumors, significantly extending mouse survival as compared to DCs expressing wild-type Db molecules. Moreover, we also observed that human DCs expressing exon 7-deleted HLA-A2 molecules showed similarly augmented CTL stimulatory ability. Mechanistic studies suggest that exon 7-deleted MHC-I molecules showed impaired lateral membrane movement and extended cell surface half-lives within the DC/T-cell interface, leading to increased spatial availability of MHC-I/peptide complexes for recognition by CD8+ T cells. Collectively, these results suggesr that targeting exon 7 within the cytoplasmic tail of MHC-I molecules in DC vaccines has the potential to enhance CD8+ T cell stimulatory capacity and improve clinical outcomes in patients with cancer or viral infections. Advisors/Committee Members: Gregory Lizee, Patrick Hwu, Stephanie Watowich.

Subjects/Keywords: Immunity; Medicine and Health Sciences

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APA (6^th Edition):

Rodriguez-Cruz, T. G. (2011). THE CYTOPLASMIC TAIL OF MHC CLASS I MOLECULES PLAYS A CRITICAL ROLE IN DENDRITIC CELL-INDUCED T CELL IMMUNITY. (Doctoral Dissertation). Texas Medical Center. Retrieved from http://digitalcommons.library.tmc.edu/utgsbs_dissertations/243

Chicago Manual of Style (16^th Edition):

Rodriguez-Cruz, Tania G. “THE CYTOPLASMIC TAIL OF MHC CLASS I MOLECULES PLAYS A CRITICAL ROLE IN DENDRITIC CELL-INDUCED T CELL IMMUNITY.” 2011. Doctoral Dissertation, Texas Medical Center. Accessed February 27, 2020. http://digitalcommons.library.tmc.edu/utgsbs_dissertations/243.

MLA Handbook (7^th Edition):

Rodriguez-Cruz, Tania G. “THE CYTOPLASMIC TAIL OF MHC CLASS I MOLECULES PLAYS A CRITICAL ROLE IN DENDRITIC CELL-INDUCED T CELL IMMUNITY.” 2011. Web. 27 Feb 2020.

Vancouver:

Rodriguez-Cruz TG. THE CYTOPLASMIC TAIL OF MHC CLASS I MOLECULES PLAYS A CRITICAL ROLE IN DENDRITIC CELL-INDUCED T CELL IMMUNITY. [Internet] [Doctoral dissertation]. Texas Medical Center; 2011. [cited 2020 Feb 27]. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/243.

Council of Science Editors:

Rodriguez-Cruz TG. THE CYTOPLASMIC TAIL OF MHC CLASS I MOLECULES PLAYS A CRITICAL ROLE IN DENDRITIC CELL-INDUCED T CELL IMMUNITY. [Doctoral Dissertation]. Texas Medical Center; 2011. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/243

Texas Medical Center

12. Zand, Behrouz. Altered ovarian cancer metabolism increases neuronal n-acetylaspartate to promote tumor growth.

Degree: MS, 2013, Texas Medical Center

URL: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/378

► Background: Altered metabolism is a well-established trait in many cancers, and is an emerging hallmark of cancer. Recent resurgence of cancer metabolism studies has… (more)

▼ Background: Altered metabolism is a well-established trait in many cancers, and is an emerging hallmark of cancer. Recent resurgence of cancer metabolism studies has identified dysregulated metabolic pathways that produce novel oncometabolites in various cancers. However, large scale studies of dysregualted high grade serous epithelial ovarian cancers (HGSOC) are unknown. Materials and Methods: Following IRB approval, metabolic profiling of 101 HGSOC patients and 15 normal ovaries were obtained using GC/LC mass spectrometry from 2 U.S. academic centers to identify highly up-regulated metabolites. Samples from a cohort of 135 and 208 patients from a single institution were evaluated for gene expression and protein expression of NAT8L, respectively. Gene expression of NAT8L and clinical outcomes were further investigated from publicly available databases from the cancer genomics atlas (TCGA) using www.cbioportal.org, and two previously published melanoma gene expression profiles. Reverse Phase Protein Array (RPPA) and gene expression array were evaluated in HeyA8 ovarian cancer cell lines to investigate the protein and gene expression changes associated with NAT8L siRNA. In vitro and in vivo v experiments of NAT8L siRNA were investigated to evaluate its effects on cancer proliferation, apoptosis, cell cycle, and invasion/migration. Results: A total of 313 metabolites were identified between these two groups, of which 172 were significantly altered (p HeyA8 and A2780 cell lines showed that NAT8L siRNA significantly increased total apoptosis compared to control (NT) siRNA by 38.53% (p Genomic analysis of HEYA8 cells transfected with NAT8L siRNA compared to NT siRNA showed 1961 significantly different gene expression data (p Conclusion: HGSOC metabolic profiling revealed highly altered metabolism compared to the normal ovary. NAA is one of the most up-regulated metabolites in HGSOC. High levels of NAA are associated with worse overall survival in HGSOC. Furthermore, high expression of its biosynthetic gene (NAT8L) is associated with vii worse overall survival in HGSOC, invasive breast, lung squamous, colon, uterine, melanoma and renal cell cancers. Inhibiting NAA production decreases tumor growth, and tilts the cancer cell to a more catabolic steady state. Therefore, our data indicate that targeting cancer’s NAA production maybe an effective therapeutic approach. Advisors/Committee Members: Dr. Anil Sood, Dr. Menashe Bar-ELi, Dr. Peiying Yang.

Subjects/Keywords: Medicine and Health Sciences

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APA (6^th Edition):

Zand, B. (2013). Altered ovarian cancer metabolism increases neuronal n-acetylaspartate to promote tumor growth. (Masters Thesis). Texas Medical Center. Retrieved from http://digitalcommons.library.tmc.edu/utgsbs_dissertations/378

Chicago Manual of Style (16^th Edition):

Zand, Behrouz. “Altered ovarian cancer metabolism increases neuronal n-acetylaspartate to promote tumor growth.” 2013. Masters Thesis, Texas Medical Center. Accessed February 27, 2020. http://digitalcommons.library.tmc.edu/utgsbs_dissertations/378.

MLA Handbook (7^th Edition):

Zand, Behrouz. “Altered ovarian cancer metabolism increases neuronal n-acetylaspartate to promote tumor growth.” 2013. Web. 27 Feb 2020.

Vancouver:

Zand B. Altered ovarian cancer metabolism increases neuronal n-acetylaspartate to promote tumor growth. [Internet] [Masters thesis]. Texas Medical Center; 2013. [cited 2020 Feb 27]. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/378.

Council of Science Editors:

Zand B. Altered ovarian cancer metabolism increases neuronal n-acetylaspartate to promote tumor growth. [Masters Thesis]. Texas Medical Center; 2013. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/378

Texas Medical Center

13. Smith, Tracey L. Ligand-Directed AAVP to Deliver a Therapeutic Transgene to Neuroendocrine Tumors of the Pancreas.

Degree: PhD, 2013, Texas Medical Center

URL: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/375

► Human pancreatic neuroendocrine tumors are rare tumors that form in the endocrine pancreas. Patients with these tumors have limited therapeutic options, and curative intervention… (more)

Subjects/Keywords: Medicine and Health Sciences

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APA (6^th Edition):

Smith, T. L. (2013). Ligand-Directed AAVP to Deliver a Therapeutic Transgene to Neuroendocrine Tumors of the Pancreas. (Doctoral Dissertation). Texas Medical Center. Retrieved from http://digitalcommons.library.tmc.edu/utgsbs_dissertations/375

Chicago Manual of Style (16^th Edition):

Smith, Tracey L. “Ligand-Directed AAVP to Deliver a Therapeutic Transgene to Neuroendocrine Tumors of the Pancreas.” 2013. Doctoral Dissertation, Texas Medical Center. Accessed February 27, 2020. http://digitalcommons.library.tmc.edu/utgsbs_dissertations/375.

MLA Handbook (7^th Edition):

Smith, Tracey L. “Ligand-Directed AAVP to Deliver a Therapeutic Transgene to Neuroendocrine Tumors of the Pancreas.” 2013. Web. 27 Feb 2020.

Vancouver:

Smith TL. Ligand-Directed AAVP to Deliver a Therapeutic Transgene to Neuroendocrine Tumors of the Pancreas. [Internet] [Doctoral dissertation]. Texas Medical Center; 2013. [cited 2020 Feb 27]. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/375.

Council of Science Editors:

Smith TL. Ligand-Directed AAVP to Deliver a Therapeutic Transgene to Neuroendocrine Tumors of the Pancreas. [Doctoral Dissertation]. Texas Medical Center; 2013. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/375

Texas Medical Center

14. Irwin, Jennifer Sierra. Characterization of the New Xoft Axxent Electronic Brachytherapy Source Using PRESAGE(TM).

Degree: MS, 2014, Texas Medical Center

URL: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/503

► With continuing advances in the burgeoning field of electronic brachytherapy, an accurate method of 3D dosimetry is needed to ensure understanding of dose distributions,… (more)

Subjects/Keywords: Medicine and Health Sciences

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APA (6^th Edition):

Irwin, J. S. (2014). Characterization of the New Xoft Axxent Electronic Brachytherapy Source Using PRESAGE(TM). (Masters Thesis). Texas Medical Center. Retrieved from http://digitalcommons.library.tmc.edu/utgsbs_dissertations/503

Chicago Manual of Style (16^th Edition):

Irwin, Jennifer Sierra. “Characterization of the New Xoft Axxent Electronic Brachytherapy Source Using PRESAGE(TM).” 2014. Masters Thesis, Texas Medical Center. Accessed February 27, 2020. http://digitalcommons.library.tmc.edu/utgsbs_dissertations/503.

MLA Handbook (7^th Edition):

Irwin, Jennifer Sierra. “Characterization of the New Xoft Axxent Electronic Brachytherapy Source Using PRESAGE(TM).” 2014. Web. 27 Feb 2020.

Vancouver:

Irwin JS. Characterization of the New Xoft Axxent Electronic Brachytherapy Source Using PRESAGE(TM). [Internet] [Masters thesis]. Texas Medical Center; 2014. [cited 2020 Feb 27]. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/503.

Council of Science Editors:

Irwin JS. Characterization of the New Xoft Axxent Electronic Brachytherapy Source Using PRESAGE(TM). [Masters Thesis]. Texas Medical Center; 2014. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/503

Texas Medical Center

15. Hsieh, Ming-Jung. Implementation of Upright Treatments for Lung and Head and Neck Cancers.

Degree: MS, 2014, Texas Medical Center

URL: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/517

► There are numerous benefits to treating patients in the upright position such as better patient comfort and increased total lung volume with reduced lung… (more)

▼ There are numerous benefits to treating patients in the upright position such as better patient comfort and increased total lung volume with reduced lung motion. The purpose of this study was to investigate the feasibility of implementing upright treatments for lung and H&N cancers. Several clinical aspects were examined, including radiation shielding for various fixed beams, collision avoidance, retrospective treatment planning, and an end-to-end test with an anthropomorphic lung phantom. Results from the shielding study indicated that the primary barrier required an additional 10-26 cm of shielding while the secondary barrier in the beam path required an additional 2-12 cm for the fixed-beam scenarios. Due to the conservative assumptions in the workloads and the NCRP computational methods, it was determined that additional shielding for a pre-existing treatment vault was not likely. However, physical measurements are required to ensure that regulatory limits are not exceeded. The collision software safely predicted all collisions for three tested cases. The differences between the computed results and the actual measurements were between 0.2-4.1 cm, which was compensated by the uncertainties incorporated into the results. The actual measured collisions were never in the area of the maps that was designated as safe. The treatment planning study resulted in clinically acceptable upright plans for five lung and five H&N patient cases. The upright lung plans produced acceptable and comparable results to those in the original plans. The dose coverage and normal tissue doses were less optimal in the upright H&N plans. However, with proper planning techniques, similar quality as the original plans is likely achievable. For the end-to-end test, the treatment plan passed the IMRT QA criteria of 0.95-1.05 for point dose and obtained a gamma index of 89.25%. Dosimetry verification demonstrated good agreement between the treatment plan doses and the delivered doses and obtained a point-dose dose difference of 2% and gamma analysis index of 100%, which were within the acceptability of IROC Houston criteria. The results of this research confirmed the feasibility of upright treatments for lung and H&N cancers and can aid the institution in future clinical studies with actual subjects. Advisors/Committee Members: Laurence E Court, Ph.D., Beth Beadle, M.D., Ph.D., Peter Balter, Ph.D..

Subjects/Keywords: Medicine and Health Sciences

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APA (6^th Edition):

Hsieh, M. (2014). Implementation of Upright Treatments for Lung and Head and Neck Cancers. (Masters Thesis). Texas Medical Center. Retrieved from http://digitalcommons.library.tmc.edu/utgsbs_dissertations/517

Chicago Manual of Style (16^th Edition):

Hsieh, Ming-Jung. “Implementation of Upright Treatments for Lung and Head and Neck Cancers.” 2014. Masters Thesis, Texas Medical Center. Accessed February 27, 2020. http://digitalcommons.library.tmc.edu/utgsbs_dissertations/517.

MLA Handbook (7^th Edition):

Hsieh, Ming-Jung. “Implementation of Upright Treatments for Lung and Head and Neck Cancers.” 2014. Web. 27 Feb 2020.

Vancouver:

Hsieh M. Implementation of Upright Treatments for Lung and Head and Neck Cancers. [Internet] [Masters thesis]. Texas Medical Center; 2014. [cited 2020 Feb 27]. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/517.

Council of Science Editors:

Hsieh M. Implementation of Upright Treatments for Lung and Head and Neck Cancers. [Masters Thesis]. Texas Medical Center; 2014. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/517

Texas Medical Center

16. Charles, Catherine T. PHENOTHIAZINES INDUCE ABORTIVE AUTOPHAGY LEADING TO CANCER CELL DEATH.

Degree: PhD, 2012, Texas Medical Center

URL: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/294

► Autophagy is an evolutionarily conserved process that functions to maintain homeostasis and provides energy during nutrient deprivation and environmental stresses for the survival of… (more)

▼ Autophagy is an evolutionarily conserved process that functions to maintain homeostasis and provides energy during nutrient deprivation and environmental stresses for the survival of cells by delivering cytoplasmic contents to the lysosomes for recycling and energy generation. Dysregulation of this process has been linked to human diseases including immune disorders, neurodegenerative muscular diseases and cancer. Autophagy is a double edged sword in that it has both pro-survival and pro-death roles in cancer cells. Its cancer suppressive roles include the clearance of damaged organelles, which could otherwise lead to inflammation and therefore promote tumorigenesis. In its pro-survival role, autophagy allows cancer cells to overcome cytotoxic stresses generated the cancer environment or cancer treatments such as chemotherapy and evade cell death. A better understanding of how drugs that perturb autophagy affect cancer cell signaling is of critical importance toimprove the cancer treatment arsenal. In order to gain insights in the relationship between autophagy and drug treatments, we conducted a high-throughput drug screen to identify autophagy modulators. Our high-throughput screen utilized image based fluorescent microscopy for single cell analysis to identify chemical perturbants of the autophagic process. Phenothiazines emerged as the largest family of drugs that alter the autophagic process by increasing LC3-II punctae levels in different cancer cell lines. In addition, we observed multiple biological effects in cancer cells treated with phenothiazines. Those antitumorigenic effects include decreased cell migration, cell viability, and ATP production along with abortive autophagy. Our studies highlight the potential role of phenothiazines as agents for combinational therapy with other chemotherapeutic agents in the treatment of different cancers. Advisors/Committee Members: Gordon B. Mills, M.D., Ph.D., Peter J. Davies, M.D., Ph.D., Honami Naora, Ph.D..

Subjects/Keywords: Medicine and Health Sciences

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APA (6^th Edition):

Charles, C. T. (2012). PHENOTHIAZINES INDUCE ABORTIVE AUTOPHAGY LEADING TO CANCER CELL DEATH. (Doctoral Dissertation). Texas Medical Center. Retrieved from http://digitalcommons.library.tmc.edu/utgsbs_dissertations/294

Chicago Manual of Style (16^th Edition):

Charles, Catherine T. “PHENOTHIAZINES INDUCE ABORTIVE AUTOPHAGY LEADING TO CANCER CELL DEATH.” 2012. Doctoral Dissertation, Texas Medical Center. Accessed February 27, 2020. http://digitalcommons.library.tmc.edu/utgsbs_dissertations/294.

MLA Handbook (7^th Edition):

Charles, Catherine T. “PHENOTHIAZINES INDUCE ABORTIVE AUTOPHAGY LEADING TO CANCER CELL DEATH.” 2012. Web. 27 Feb 2020.

Vancouver:

Charles CT. PHENOTHIAZINES INDUCE ABORTIVE AUTOPHAGY LEADING TO CANCER CELL DEATH. [Internet] [Doctoral dissertation]. Texas Medical Center; 2012. [cited 2020 Feb 27]. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/294.

Council of Science Editors:

Charles CT. PHENOTHIAZINES INDUCE ABORTIVE AUTOPHAGY LEADING TO CANCER CELL DEATH. [Doctoral Dissertation]. Texas Medical Center; 2012. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/294

Texas Medical Center

17. timsah, zahra. COMPETITION BETWEEN GRB2 AND PLCγ1 FOR BINDING TO FGFR2 REGULATES PHOSPHOLIPASE AND PTEN ACTIVITY, LEADING TO CELL INVASION AND PROLIFERATION.

Degree: PhD, 2014, Texas Medical Center

URL: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/422

► @font-face { font-family: "Arial"; }@font-face { font-family: "Calibri"; }p.MsoNormal, li.MsoNormal, div.MsoNormal { margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: Arial; }p.MsoNoSpacing, li.MsoNoSpacing, div.MsoNoSpacing {… (more)

Subjects/Keywords: Medicine and Health Sciences

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APA (6^th Edition):

timsah, z. (2014). COMPETITION BETWEEN GRB2 AND PLCγ1 FOR BINDING TO FGFR2 REGULATES PHOSPHOLIPASE AND PTEN ACTIVITY, LEADING TO CELL INVASION AND PROLIFERATION. (Doctoral Dissertation). Texas Medical Center. Retrieved from http://digitalcommons.library.tmc.edu/utgsbs_dissertations/422

Chicago Manual of Style (16^th Edition):

timsah, zahra. “COMPETITION BETWEEN GRB2 AND PLCγ1 FOR BINDING TO FGFR2 REGULATES PHOSPHOLIPASE AND PTEN ACTIVITY, LEADING TO CELL INVASION AND PROLIFERATION.” 2014. Doctoral Dissertation, Texas Medical Center. Accessed February 27, 2020. http://digitalcommons.library.tmc.edu/utgsbs_dissertations/422.

MLA Handbook (7^th Edition):

timsah, zahra. “COMPETITION BETWEEN GRB2 AND PLCγ1 FOR BINDING TO FGFR2 REGULATES PHOSPHOLIPASE AND PTEN ACTIVITY, LEADING TO CELL INVASION AND PROLIFERATION.” 2014. Web. 27 Feb 2020.

Vancouver:

timsah z. COMPETITION BETWEEN GRB2 AND PLCγ1 FOR BINDING TO FGFR2 REGULATES PHOSPHOLIPASE AND PTEN ACTIVITY, LEADING TO CELL INVASION AND PROLIFERATION. [Internet] [Doctoral dissertation]. Texas Medical Center; 2014. [cited 2020 Feb 27]. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/422.

Council of Science Editors:

timsah z. COMPETITION BETWEEN GRB2 AND PLCγ1 FOR BINDING TO FGFR2 REGULATES PHOSPHOLIPASE AND PTEN ACTIVITY, LEADING TO CELL INVASION AND PROLIFERATION. [Doctoral Dissertation]. Texas Medical Center; 2014. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/422

Texas Medical Center

18. Aslan, Burcu. DUAL ASSEMBLY NANOPARTICLES ACHIEVE SUSTAINED SILENCING OF ZNF304: A NOVEL TRANSCRIPTION FACTOR FOR Β1 INTEGRIN.

Degree: PhD, 2014, Texas Medical Center

URL: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/541

► Ovarian cancer (OC) is a highly metastatic disease, but no effective strategies to this process currently are known. Here, an integrated computational analysis of… (more)

Subjects/Keywords: Medicine and Health Sciences

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APA (6^th Edition):

Aslan, B. (2014). DUAL ASSEMBLY NANOPARTICLES ACHIEVE SUSTAINED SILENCING OF ZNF304: A NOVEL TRANSCRIPTION FACTOR FOR Β1 INTEGRIN. (Doctoral Dissertation). Texas Medical Center. Retrieved from http://digitalcommons.library.tmc.edu/utgsbs_dissertations/541

Chicago Manual of Style (16^th Edition):

Aslan, Burcu. “DUAL ASSEMBLY NANOPARTICLES ACHIEVE SUSTAINED SILENCING OF ZNF304: A NOVEL TRANSCRIPTION FACTOR FOR Β1 INTEGRIN.” 2014. Doctoral Dissertation, Texas Medical Center. Accessed February 27, 2020. http://digitalcommons.library.tmc.edu/utgsbs_dissertations/541.

MLA Handbook (7^th Edition):

Aslan, Burcu. “DUAL ASSEMBLY NANOPARTICLES ACHIEVE SUSTAINED SILENCING OF ZNF304: A NOVEL TRANSCRIPTION FACTOR FOR Β1 INTEGRIN.” 2014. Web. 27 Feb 2020.

Vancouver:

Aslan B. DUAL ASSEMBLY NANOPARTICLES ACHIEVE SUSTAINED SILENCING OF ZNF304: A NOVEL TRANSCRIPTION FACTOR FOR Β1 INTEGRIN. [Internet] [Doctoral dissertation]. Texas Medical Center; 2014. [cited 2020 Feb 27]. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/541.

Council of Science Editors:

Aslan B. DUAL ASSEMBLY NANOPARTICLES ACHIEVE SUSTAINED SILENCING OF ZNF304: A NOVEL TRANSCRIPTION FACTOR FOR Β1 INTEGRIN. [Doctoral Dissertation]. Texas Medical Center; 2014. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/541

Texas Medical Center

19. Goonatilake, Ruchitha. Determining Mechanisms of Response to Polo-like Kinase 1 Inhibition in Non-Small Cell Lung Cancer.

Degree: MS, 2016, Texas Medical Center

URL: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/700

► Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. The discovery of genetic alterations in some patients (~15%) has made… (more)

Subjects/Keywords: Medicine and Health Sciences

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APA (6^th Edition):

Goonatilake, R. (2016). Determining Mechanisms of Response to Polo-like Kinase 1 Inhibition in Non-Small Cell Lung Cancer. (Masters Thesis). Texas Medical Center. Retrieved from http://digitalcommons.library.tmc.edu/utgsbs_dissertations/700

Chicago Manual of Style (16^th Edition):

Goonatilake, Ruchitha. “Determining Mechanisms of Response to Polo-like Kinase 1 Inhibition in Non-Small Cell Lung Cancer.” 2016. Masters Thesis, Texas Medical Center. Accessed February 27, 2020. http://digitalcommons.library.tmc.edu/utgsbs_dissertations/700.

MLA Handbook (7^th Edition):

Goonatilake, Ruchitha. “Determining Mechanisms of Response to Polo-like Kinase 1 Inhibition in Non-Small Cell Lung Cancer.” 2016. Web. 27 Feb 2020.

Vancouver:

Goonatilake R. Determining Mechanisms of Response to Polo-like Kinase 1 Inhibition in Non-Small Cell Lung Cancer. [Internet] [Masters thesis]. Texas Medical Center; 2016. [cited 2020 Feb 27]. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/700.

Council of Science Editors:

Goonatilake R. Determining Mechanisms of Response to Polo-like Kinase 1 Inhibition in Non-Small Cell Lung Cancer. [Masters Thesis]. Texas Medical Center; 2016. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/700

Texas Medical Center

20. Fletcher, Eliot S. ORGAN SPECIFIC VASCULAR RESPONSE TO FIBROSIS AFFECTS BREAST CANCER METASTATIC ORGANOTROPISM.

Degree: PhD, 2016, Texas Medical Center

URL: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/723

► The solid tumor microenvironment, pre-metastatic niche, and fibrotic environment are known to have significant biochemical and biomechanical similarities to the fibrotic environment. All have… (more)

▼ The solid tumor microenvironment, pre-metastatic niche, and fibrotic environment are known to have significant biochemical and biomechanical similarities to the fibrotic environment. All have significantly increased levels of factors such as TGFβ, HIF1α, TNFα, PDGF, VEGF, FGF, interleukins and other growth factors that are known to be pro-tumorigenic. Clinical and basic science research has shown that fibrosis presents an environment that favors tumor growth, such as hepatocellular carcinoma being commonly preceded by liver cirrhosis, or bleomycin induced lung fibrosis enhancing pulmonary metastasis in mouse models of breast cancer. In addition to the evidence indicating that fibrosis enhances primary tumor growth and metastasis it is also well characterized that primary tumor metastasis has specific organotropism, for example breast cancer commonly spreads to the lungs, brain, bone, liver and lymph nodes. However, whether non-organtropic fibrosis can redirect metastasis to the damaged organ has not been investigated. To elucidate the fibrotic effect on tumor organotropism we induced fibrosis in the organotropic lungs and in the non-organotropic kidney of two mouse models of breast cancer, the 4T1 murine cancer cell line model and the genetic MMTV-Pymt model, both of which are known to metastasize. Using histopathology, microarrays, gene expression by polymerase chain reaction, ELISA, chemokine array, and in vitro experiments we demonstrate that despite the pro-tumorigenic environment, kidney fibrosis does not redirect metastasis to the non-organotropic damaged organ. However, mice with kidney fibrosis had increased metastasis to their lungs. Furthermore, we found that kidney fibrosis increases the circulating levels of the pro-angiogenic factor Angiopoietin 2 that increased vascular permeability of the lungs, but not the kidneys. In fact, while fibrotic lungs showed decreased expression of endothelial tight gap junction protein Claudin-5, the fibrotic kidneys had an elevated expression of Claudin-5. Our findings suggest that despite the similarities between fibrosis, the tumor microenvironment and the pre-metastatic niche, that while it can enhance tropic metastatic disease, it cannot redirect organotropism indicating that other factors must be involved in directing organotropism. Here we report that tumor organotropism may be a result of organ specific vascular responses to excess circulating factors and increased fibrotic factors. These findings indicate that organotropism is directly related to and as a result of organ specific vascular alterations. Advisors/Committee Members: Raghu Kalluri, Valerie LeBleu, Menasche Bar Eli.

Subjects/Keywords: Medicine and Health Sciences

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APA (6^th Edition):

Fletcher, E. S. (2016). ORGAN SPECIFIC VASCULAR RESPONSE TO FIBROSIS AFFECTS BREAST CANCER METASTATIC ORGANOTROPISM. (Doctoral Dissertation). Texas Medical Center. Retrieved from http://digitalcommons.library.tmc.edu/utgsbs_dissertations/723

Chicago Manual of Style (16^th Edition):

Fletcher, Eliot S. “ORGAN SPECIFIC VASCULAR RESPONSE TO FIBROSIS AFFECTS BREAST CANCER METASTATIC ORGANOTROPISM.” 2016. Doctoral Dissertation, Texas Medical Center. Accessed February 27, 2020. http://digitalcommons.library.tmc.edu/utgsbs_dissertations/723.

MLA Handbook (7^th Edition):

Fletcher, Eliot S. “ORGAN SPECIFIC VASCULAR RESPONSE TO FIBROSIS AFFECTS BREAST CANCER METASTATIC ORGANOTROPISM.” 2016. Web. 27 Feb 2020.

Vancouver:

Fletcher ES. ORGAN SPECIFIC VASCULAR RESPONSE TO FIBROSIS AFFECTS BREAST CANCER METASTATIC ORGANOTROPISM. [Internet] [Doctoral dissertation]. Texas Medical Center; 2016. [cited 2020 Feb 27]. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/723.

Council of Science Editors:

Fletcher ES. ORGAN SPECIFIC VASCULAR RESPONSE TO FIBROSIS AFFECTS BREAST CANCER METASTATIC ORGANOTROPISM. [Doctoral Dissertation]. Texas Medical Center; 2016. Available from: http://digitalcommons.library.tmc.edu/utgsbs_dissertations/723

Southern Cross University

21. Avila, Catharine. The effect of nutritional supplementation on premenstrual syndrome.

Degree: 2009, Southern Cross University

URL: http://epubs.scu.edu.au/theses/180

► Premenstrual syndrome (PMS) occurs during the luteal phase of ovulatory menstrual cycles characterized by disrupting psychological and physical symptoms, which are relieved during menstruation. Around… (more)

▼ Premenstrual syndrome (PMS) occurs during the luteal phase of ovulatory menstrual cycles characterized by disrupting psychological and physical symptoms, which are relieved during menstruation. Around 20% of women experience PMS across social, ethnic and cultural groups. The aim of this thesis was to investigate the therapeutic potential of nutritional supplements for mild to moderate PMS. The aetiology of PMS remains obscure; genetic and environmental vulnerabilities have been identified yet no specific pathophysiology has been established. Neurotransmitter systems with their reciprocal relationship to the hypothalamic-pituitary-gonadal axis, are implicated in PMS. The catecholamine, serotonergic and GABA systems each modulate aspects of the synthesis, release and inhibitory feedback mechanisms involved in the menstrual cycle. Progesterone, its metabolites and oestrogen also act as neurosteroids modulating neurotransmitter systems. A role for the serotonergic system in PMS is supported in a proportion of sufferers. A transitory dysfunction in homeostasis is thought to account for the on/off nature of PMS symptoms. One hypothesis suggests that a dysfunction in calcium metabolism involving a lack of sensitivity to parathyroid hormone and a transitory deficiency in extra and intracellular calcium ions, leads to disruptions in receptor site activity, giving rise to symptoms. This thesis supports elements of this theory. Micronutrient cofactors are intrinsic to neurotransmitter synthesis and receptor site function and adequate provision of micronutrients for these functions provides one rationale for their use in the treatment of PMS. A systematic review of methodologically sound clinical trials of nutritional interventions in PMS found evidence for the efficacy of calcium, tryptophan, magnesium, pyridoxine and a micronutrient formula. The effect of two complexes on symptoms of mild to moderate PMS were investigated. Methodological considerations specific to the study of PMS include appropriate assessment and interpretation of definitions. A mixed-methods study of three PMS assessment instruments informed the choice of instrument used in the trials. A double-blind clinical trial with parallel groups investigated a multivitamin complex compared to placebo. Healthy participants recorded symptoms for two menstrual cycles allowing confirmation of PMS prior to randomization and a four menstrual cycle intervention stage. Daily symptom recordings were maintained. A hierarchical regression model was fitted to the natural logarithm of the data. Women taking the micronutrient complex experienced a highly significant reduction in symptoms of PMS compared to placebo (p<0.000). A second trial with similar methodology had three arms; calcium complex alone, calcium complex with the multivitamin complex and a placebo arm. The groups taking the calcium alone and combined with the multivitamin experienced significant reduction in symptoms compared to placebo, p It was postulated a dysregulation of calcium metabolism might be reflected in…

Subjects/Keywords: Medicine and Health Sciences

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APA (6^th Edition):

Avila, C. (2009). The effect of nutritional supplementation on premenstrual syndrome. (Thesis). Southern Cross University. Retrieved from http://epubs.scu.edu.au/theses/180

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Avila, Catharine. “The effect of nutritional supplementation on premenstrual syndrome.” 2009. Thesis, Southern Cross University. Accessed February 27, 2020. http://epubs.scu.edu.au/theses/180.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Avila, Catharine. “The effect of nutritional supplementation on premenstrual syndrome.” 2009. Web. 27 Feb 2020.

Vancouver:

Avila C. The effect of nutritional supplementation on premenstrual syndrome. [Internet] [Thesis]. Southern Cross University; 2009. [cited 2020 Feb 27]. Available from: http://epubs.scu.edu.au/theses/180.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Avila C. The effect of nutritional supplementation on premenstrual syndrome. [Thesis]. Southern Cross University; 2009. Available from: http://epubs.scu.edu.au/theses/180

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Louisville

22. Hollis, Elizabeth Marie. Diffusion-weighted magnetic resonance imaging in diagnosing graft dysfunction : a non-invasive alternative to renal biopsy.

Degree: MS, 2017, University of Louisville

URL: 10.18297/etd/2661 ; https://ir.library.louisville.edu/etd/2661

► The thesis is divided into three parts. The first part focuses on background information including how the kidney functions, diseases, and available kidney disease… (more)

Subjects/Keywords: Medicine and Health Sciences

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APA (6^th Edition):

Hollis, E. M. (2017). Diffusion-weighted magnetic resonance imaging in diagnosing graft dysfunction : a non-invasive alternative to renal biopsy. (Masters Thesis). University of Louisville. Retrieved from 10.18297/etd/2661 ; https://ir.library.louisville.edu/etd/2661

Chicago Manual of Style (16^th Edition):

Hollis, Elizabeth Marie. “Diffusion-weighted magnetic resonance imaging in diagnosing graft dysfunction : a non-invasive alternative to renal biopsy.” 2017. Masters Thesis, University of Louisville. Accessed February 27, 2020. 10.18297/etd/2661 ; https://ir.library.louisville.edu/etd/2661.

MLA Handbook (7^th Edition):

Hollis, Elizabeth Marie. “Diffusion-weighted magnetic resonance imaging in diagnosing graft dysfunction : a non-invasive alternative to renal biopsy.” 2017. Web. 27 Feb 2020.

Vancouver:

Hollis EM. Diffusion-weighted magnetic resonance imaging in diagnosing graft dysfunction : a non-invasive alternative to renal biopsy. [Internet] [Masters thesis]. University of Louisville; 2017. [cited 2020 Feb 27]. Available from: 10.18297/etd/2661 ; https://ir.library.louisville.edu/etd/2661.

Council of Science Editors:

Hollis EM. Diffusion-weighted magnetic resonance imaging in diagnosing graft dysfunction : a non-invasive alternative to renal biopsy. [Masters Thesis]. University of Louisville; 2017. Available from: 10.18297/etd/2661 ; https://ir.library.louisville.edu/etd/2661

University of South Carolina

23. Wrigglesworth, Kathryn. Psychiatric Patients In the Emergency Department: An Evidence-Based Assessment tool For Inpatient Referral.

Degree: DNP, College of Nursing, 2009, University of South Carolina

URL: https://scholarcommons.sc.edu/etd/113

► Psychiatric patients who present to Emergency Departments (ED) are a growing population. These patients are challenging cases for ED healthcare providers who do not… (more)

Subjects/Keywords: Medicine and Health Sciences; Nursing

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APA (6^th Edition):

Wrigglesworth, K. (2009). Psychiatric Patients In the Emergency Department: An Evidence-Based Assessment tool For Inpatient Referral. (Thesis). University of South Carolina. Retrieved from https://scholarcommons.sc.edu/etd/113

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wrigglesworth, Kathryn. “Psychiatric Patients In the Emergency Department: An Evidence-Based Assessment tool For Inpatient Referral.” 2009. Thesis, University of South Carolina. Accessed February 27, 2020. https://scholarcommons.sc.edu/etd/113.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wrigglesworth, Kathryn. “Psychiatric Patients In the Emergency Department: An Evidence-Based Assessment tool For Inpatient Referral.” 2009. Web. 27 Feb 2020.

Vancouver:

Wrigglesworth K. Psychiatric Patients In the Emergency Department: An Evidence-Based Assessment tool For Inpatient Referral. [Internet] [Thesis]. University of South Carolina; 2009. [cited 2020 Feb 27]. Available from: https://scholarcommons.sc.edu/etd/113.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wrigglesworth K. Psychiatric Patients In the Emergency Department: An Evidence-Based Assessment tool For Inpatient Referral. [Thesis]. University of South Carolina; 2009. Available from: https://scholarcommons.sc.edu/etd/113

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of South Carolina

24. Clark, Amy Jeanette. A Best Practice Guideline for Screening and Treating Vitamin D Deficiency in a Primary Care Setting: Moving Beyond the Bones.

Degree: D.N.P., College of Nursing, 2010, University of South Carolina

URL: https://scholarcommons.sc.edu/etd/323

► The importance of vitamin D to bone health is well known, yet new research has linked vitamin D to numerous chronic diseases severely affecting… (more)

Subjects/Keywords: Medicine and Health Sciences; Nursing

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APA (6^th Edition):

Clark, A. J. (2010). A Best Practice Guideline for Screening and Treating Vitamin D Deficiency in a Primary Care Setting: Moving Beyond the Bones. (Doctoral Dissertation). University of South Carolina. Retrieved from https://scholarcommons.sc.edu/etd/323

Chicago Manual of Style (16^th Edition):

Clark, Amy Jeanette. “A Best Practice Guideline for Screening and Treating Vitamin D Deficiency in a Primary Care Setting: Moving Beyond the Bones.” 2010. Doctoral Dissertation, University of South Carolina. Accessed February 27, 2020. https://scholarcommons.sc.edu/etd/323.

MLA Handbook (7^th Edition):

Clark, Amy Jeanette. “A Best Practice Guideline for Screening and Treating Vitamin D Deficiency in a Primary Care Setting: Moving Beyond the Bones.” 2010. Web. 27 Feb 2020.

Vancouver:

Clark AJ. A Best Practice Guideline for Screening and Treating Vitamin D Deficiency in a Primary Care Setting: Moving Beyond the Bones. [Internet] [Doctoral dissertation]. University of South Carolina; 2010. [cited 2020 Feb 27]. Available from: https://scholarcommons.sc.edu/etd/323.

Council of Science Editors:

Clark AJ. A Best Practice Guideline for Screening and Treating Vitamin D Deficiency in a Primary Care Setting: Moving Beyond the Bones. [Doctoral Dissertation]. University of South Carolina; 2010. Available from: https://scholarcommons.sc.edu/etd/323

University of South Carolina

25. Shake, Eileene Elizabeth. Dedicated Education Units: Dothey Improve Student Satisfaction?.

Degree: D.N.P., College of Nursing, 2010, University of South Carolina

URL: https://scholarcommons.sc.edu/etd/404

► The nursing profession is facing today, and in the future, a severe shortage of registered nurses and nurse educators. Currently hospitals and universities are… (more)

Subjects/Keywords: Medicine and Health Sciences; Nursing

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APA (6^th Edition):

Shake, E. E. (2010). Dedicated Education Units: Dothey Improve Student Satisfaction?. (Doctoral Dissertation). University of South Carolina. Retrieved from https://scholarcommons.sc.edu/etd/404

Chicago Manual of Style (16^th Edition):

Shake, Eileene Elizabeth. “Dedicated Education Units: Dothey Improve Student Satisfaction?.” 2010. Doctoral Dissertation, University of South Carolina. Accessed February 27, 2020. https://scholarcommons.sc.edu/etd/404.

MLA Handbook (7^th Edition):

Shake, Eileene Elizabeth. “Dedicated Education Units: Dothey Improve Student Satisfaction?.” 2010. Web. 27 Feb 2020.

Vancouver:

Shake EE. Dedicated Education Units: Dothey Improve Student Satisfaction?. [Internet] [Doctoral dissertation]. University of South Carolina; 2010. [cited 2020 Feb 27]. Available from: https://scholarcommons.sc.edu/etd/404.

Council of Science Editors:

Shake EE. Dedicated Education Units: Dothey Improve Student Satisfaction?. [Doctoral Dissertation]. University of South Carolina; 2010. Available from: https://scholarcommons.sc.edu/etd/404

University of South Carolina

26. Blottner, Christina Pacileo. The Impact of the Patient Protection and Affordable Care Act of 2010 On the Evidence Based Practice of Distributive Justice Via Comfort Care In Elderly Burn Trauma Victims.

Degree: D.N.P., College of Nursing, 2011, University of South Carolina

URL: https://scholarcommons.sc.edu/etd/1675

► Burn injuries devastate lives. Mere survival demonstrates both the amazing recuperative capacity of the human body and the remarkable advance of modern healthcare. The… (more)

▼ Burn injuries devastate lives. Mere survival demonstrates both the amazing recuperative capacity of the human body and the remarkable advance of modern healthcare. The Patient Protection and Affordable Care Act of 2010 (PPACA) mandates the early identification of goals-of-care through shared decision-making. Survival, even for very large burns, is an expectation for every patient population with one notable exception, the elderly. The following clinical question is posed: 'Does the provision of curative care versus comfort care meet the ethical obligation of distributive justice in elderly patients who sustain greater than 60% total body surface area burns?' The elderly continue to see comparatively disproportionate mortality in these large burns regardless of care intensity and present unique challenges to the U.S. healthcare system. Ethical codes prescribe moral conduct and role responsibilities for healthcare professionals. The ethical principle of distributive justice, both theoretical and applied, is considered in light of the outcome evidence for this vulnerable population. In terms of both social economy and human burden distributive justice, the reflexive pursuit of futile curative care is inappropriate. A less expensive, more humane alternative to curative care exists,comfort care, that produces similar outcomes. A clinical algorithm for the care of elderly burn patients with very large body surface area burns is presented as supported by clinical evidence. In addition, an individualized patient decision aid (PtDA) is proposed as mandated by PPACA, that aims to engender compassion, dignity and relief of suffering during the difficult process of shared decision-making in the face of mortal burn trauma. In burn care, success is often measured by survival, functionality, and quality of life. When the historical measures of successful care cannot be applied, PPACA, professional ethics and human compassion can help to definitionally expand successful care to include the provision of a good death. Advisors/Committee Members: JoAnne Herman, Joan M Culley.

Subjects/Keywords: Medicine and Health Sciences; Nursing

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APA (6^th Edition):

Blottner, C. P. (2011). The Impact of the Patient Protection and Affordable Care Act of 2010 On the Evidence Based Practice of Distributive Justice Via Comfort Care In Elderly Burn Trauma Victims. (Doctoral Dissertation). University of South Carolina. Retrieved from https://scholarcommons.sc.edu/etd/1675

Chicago Manual of Style (16^th Edition):

Blottner, Christina Pacileo. “The Impact of the Patient Protection and Affordable Care Act of 2010 On the Evidence Based Practice of Distributive Justice Via Comfort Care In Elderly Burn Trauma Victims.” 2011. Doctoral Dissertation, University of South Carolina. Accessed February 27, 2020. https://scholarcommons.sc.edu/etd/1675.

MLA Handbook (7^th Edition):

Blottner, Christina Pacileo. “The Impact of the Patient Protection and Affordable Care Act of 2010 On the Evidence Based Practice of Distributive Justice Via Comfort Care In Elderly Burn Trauma Victims.” 2011. Web. 27 Feb 2020.

Vancouver:

Blottner CP. The Impact of the Patient Protection and Affordable Care Act of 2010 On the Evidence Based Practice of Distributive Justice Via Comfort Care In Elderly Burn Trauma Victims. [Internet] [Doctoral dissertation]. University of South Carolina; 2011. [cited 2020 Feb 27]. Available from: https://scholarcommons.sc.edu/etd/1675.

Council of Science Editors:

Blottner CP. The Impact of the Patient Protection and Affordable Care Act of 2010 On the Evidence Based Practice of Distributive Justice Via Comfort Care In Elderly Burn Trauma Victims. [Doctoral Dissertation]. University of South Carolina; 2011. Available from: https://scholarcommons.sc.edu/etd/1675

University of South Carolina

27. Belhaj, Marwa. Cellular and Biochemical Effects of Sparstolonin B on Endothelial Cells to Inhibit Angiogenesis.

Degree: MS, Biomedical Science, 2014, University of South Carolina

URL: https://scholarcommons.sc.edu/etd/2654

► Angiogenesis is the process of new blood vessel development by endothelial cells from pre-existing vasculature; however, abnormal angiogenesis contributes to the pathogenesis of many… (more)

Subjects/Keywords: Medicine and Health Sciences

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APA (6^th Edition):

Belhaj, M. (2014). Cellular and Biochemical Effects of Sparstolonin B on Endothelial Cells to Inhibit Angiogenesis. (Masters Thesis). University of South Carolina. Retrieved from https://scholarcommons.sc.edu/etd/2654

Chicago Manual of Style (16^th Edition):

Belhaj, Marwa. “Cellular and Biochemical Effects of Sparstolonin B on Endothelial Cells to Inhibit Angiogenesis.” 2014. Masters Thesis, University of South Carolina. Accessed February 27, 2020. https://scholarcommons.sc.edu/etd/2654.

MLA Handbook (7^th Edition):

Belhaj, Marwa. “Cellular and Biochemical Effects of Sparstolonin B on Endothelial Cells to Inhibit Angiogenesis.” 2014. Web. 27 Feb 2020.

Vancouver:

Belhaj M. Cellular and Biochemical Effects of Sparstolonin B on Endothelial Cells to Inhibit Angiogenesis. [Internet] [Masters thesis]. University of South Carolina; 2014. [cited 2020 Feb 27]. Available from: https://scholarcommons.sc.edu/etd/2654.

Council of Science Editors:

Belhaj M. Cellular and Biochemical Effects of Sparstolonin B on Endothelial Cells to Inhibit Angiogenesis. [Masters Thesis]. University of South Carolina; 2014. Available from: https://scholarcommons.sc.edu/etd/2654

28. Pion, Johan. The Flemish Sports Compass: from sports orientation to elite performance prediction.

Degree: 2015, Ghent University

URL: http://hdl.handle.net/1854/LU-6993997

► The road from beginner to sports champion is a long and unpredictable one. Therefore, choosing a sport that fits their individual characteristics is essential for… (more)

▼ The road from beginner to sports champion is a long and unpredictable one. Therefore, choosing a sport that fits their individual characteristics is essential for children to keep them involved in sports. The Flemish Sports Compass is a generic test battery designed to advise children in their sports choice. The test battery includes anthropometric, physical and motor performance measurements and it has the special quality that, in addition to talent detection and talent orientation, it also enhances various derivative test batteries for talent identification. The Flemish Sports Compass consists of field tests appliable in both elementary schools children and in Flemish elite sport schools. On the one hand it is possible to discriminate between different performance levels and on the other this test battery has te ability to detect sport-specific characteristics of an individual. First part of this doctoral dissertation consists of two introductory chapters. The first chapter provides an overview of definitions, theoretical talent models and practical talent systems. The second chapter explains the rationale and the design of the Flemish Sports Compass and displays the preliminary studies for designing the Flemish Sports Compass. In the second part of this dissertation, six original studies are reported. The first study highlights the potential of the Flemish Sports Compass for primary school children. In this study the differences between the sport specific profiles are less pronounced than in the second and the third study, which measured respectively the students of the Flemish elite sport schools and promising athletes of different sports federations. The first three studies indicated that the generic test battery can be deployed on beginners (talent detection) as well as elite athletes (talent identification). The fourth study, with increased specificity, indicates that the generic tests of the Flemish Sports Compass also are able to distinguish between medallists in international competitions and subelite volleyball players. The talent characteristics measured by the Flemish Sports Compass are not only good at predicting and identifying elite level, they also predict attrition in sport. In the fifth study, survival analysis was applied. Parallel to the methods used in medical science where examining the outcome of medication on the participants life expectations is the main goal, survival chances of athletes were calculated in our fifth study. The last study indicated the importance of predictive analytics of a generic test battery. It was shown that artificial neural networks reduce the risk of missing gifted athletes, when selecting the high potential athletes and how the cost of talent development can be reduced without losing talents. In the third part of this dissertation results are discussed and critical reflections and recommendations are given. The different studies provide opportunities to develop a specific talent system for a small country. Flanders’ disadvantage is, that it is hard to compete with… Advisors/Committee Members: Lenoir, Matthieu, Segers, Veerle.

Subjects/Keywords: Medicine and Health Sciences

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APA (6^th Edition):

Pion, J. (2015). The Flemish Sports Compass: from sports orientation to elite performance prediction. (Thesis). Ghent University. Retrieved from http://hdl.handle.net/1854/LU-6993997

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pion, Johan. “The Flemish Sports Compass: from sports orientation to elite performance prediction.” 2015. Thesis, Ghent University. Accessed February 27, 2020. http://hdl.handle.net/1854/LU-6993997.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pion, Johan. “The Flemish Sports Compass: from sports orientation to elite performance prediction.” 2015. Web. 27 Feb 2020.

Vancouver:

Pion J. The Flemish Sports Compass: from sports orientation to elite performance prediction. [Internet] [Thesis]. Ghent University; 2015. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/1854/LU-6993997.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pion J. The Flemish Sports Compass: from sports orientation to elite performance prediction. [Thesis]. Ghent University; 2015. Available from: http://hdl.handle.net/1854/LU-6993997

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. De Frène, Veerle. Psychological, perinatal, lifestyle and health-economic aspects of the polycystic ovary syndrome : what really matters for the patient, her family and the society.

Degree: 2015, Ghent University

URL: http://hdl.handle.net/1854/LU-6999103

► Study question: How are objective characteristics of the polycystic ovary syndrome (PCOS) and PCOS-related concerns associated with the sexual and relational satisfaction of PCOS women… (more)

▼ Study question: How are objective characteristics of the polycystic ovary syndrome (PCOS) and PCOS-related concerns associated with the sexual and relational satisfaction of PCOS women and their partners? Summary answer: Both objective PCOS characteristics (parity, women’s body mass index (BMI) and current unfulfilled wish to conceive) and PCOS-related concerns (women’s infertility-related and acne-related concerns) were associated with sexual and/or relational satisfaction, although some associations differed for PCOS women and their partners. What is known already: There is some evidence indicating an association between objective PCOS characteristics and sexual satisfaction of PCOS women, but this evidence is conflicting, scarce, and often no validated questionnaires are used to evaluate sexual satisfaction. No evidence is available about the association of (i) PCOS with relational satisfaction; (ii) PCOS-related concerns with sexual and relational satisfaction; and (iii) PCOS with sexual and relational satisfaction as experienced by partners of PCOS women. Study design, size, duration: We set up a cross sectional study from April 2007 till April 2009 including 31 overweight (BMI ≥ 25 kg/m²) women with PCOS at reproductive age as well as their partners with who they had a committed intimate relationship at the time of recruitment. Participants/materials, setting, methods: The study was performed at the fertility center of the Ghent University Hospital. Objective PCOS characteristics were registered and PCOS-related concerns were evaluated by the PCOS Questionnaire. Sexual (SS) and relational (RS) satisfaction were measured by the Maudsley Marital Questionnaire (MMQ). Dyadic statistical analyses were performed using linear mixed models (α < 0.05). Main results and the role of chance: A lower parity tended to be associated with higher levels of sexual and relational satisfaction, with a significantly stronger association in PCOS women than their partners (p(SS) = .015 and p(RS) = .009). A higher BMI tended to be associated with lower and higher satisfaction levels (sexual and relational) in PCOS women and their partners, respectively, with a significantly stronger association in the partners (p(SS) = .029 and p(RS) = .021). The presence of a current unfulfilled wish to conceive and a higher level of infertility-related concerns was significantly stronger associated with a higher level of PCOS women’s relational satisfaction than their partners’ (p(RS) = .021 and p(RS) = .011, respectively). And higher levels of acne-related concern were significantly associated with lower levels of sexual satisfaction in PCOS women (p(SS) = .025) and their partners (p(SS) = .002). Limitations, reasons for caution: The fact that this study was performed in a sample of PCOS women who were all overweight and the small sample size are important limitations. Data were partially missing in some couples but this limitation was dealt with by using linear mixed models. Wider implications of the findings: Our results suggest a differential… Advisors/Committee Members: De Sutter, Petra, Annemans, Lieven.

Subjects/Keywords: Medicine and Health Sciences

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APA (6^th Edition):

De Frène, V. (2015). Psychological, perinatal, lifestyle and health-economic aspects of the polycystic ovary syndrome : what really matters for the patient, her family and the society. (Thesis). Ghent University. Retrieved from http://hdl.handle.net/1854/LU-6999103

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

De Frène, Veerle. “Psychological, perinatal, lifestyle and health-economic aspects of the polycystic ovary syndrome : what really matters for the patient, her family and the society.” 2015. Thesis, Ghent University. Accessed February 27, 2020. http://hdl.handle.net/1854/LU-6999103.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

De Frène, Veerle. “Psychological, perinatal, lifestyle and health-economic aspects of the polycystic ovary syndrome : what really matters for the patient, her family and the society.” 2015. Web. 27 Feb 2020.

Vancouver:

De Frène V. Psychological, perinatal, lifestyle and health-economic aspects of the polycystic ovary syndrome : what really matters for the patient, her family and the society. [Internet] [Thesis]. Ghent University; 2015. [cited 2020 Feb 27]. Available from: http://hdl.handle.net/1854/LU-6999103.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

De Frène V. Psychological, perinatal, lifestyle and health-economic aspects of the polycystic ovary syndrome : what really matters for the patient, her family and the society. [Thesis]. Ghent University; 2015. Available from: http://hdl.handle.net/1854/LU-6999103

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Pennsylvania

30. Rech, Andrew J. Determinants Of Adaptive Immunity In Cancer.

Degree: 2017, University of Pennsylvania

URL: https://repository.upenn.edu/edissertations/2543

► Immune checkpoint blockade results in T cell antitumor responses but most patients fail to respond. This raises fundamental questions about mechanisms of tumor immune recognition… (more)

Subjects/Keywords: Medicine and Health Sciences

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APA (6^th Edition):

Rech, A. J. (2017). Determinants Of Adaptive Immunity In Cancer. (Thesis). University of Pennsylvania. Retrieved from https://repository.upenn.edu/edissertations/2543

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rech, Andrew J. “Determinants Of Adaptive Immunity In Cancer.” 2017. Thesis, University of Pennsylvania. Accessed February 27, 2020. https://repository.upenn.edu/edissertations/2543.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rech, Andrew J. “Determinants Of Adaptive Immunity In Cancer.” 2017. Web. 27 Feb 2020.

Vancouver:

Rech AJ. Determinants Of Adaptive Immunity In Cancer. [Internet] [Thesis]. University of Pennsylvania; 2017. [cited 2020 Feb 27]. Available from: https://repository.upenn.edu/edissertations/2543.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rech AJ. Determinants Of Adaptive Immunity In Cancer. [Thesis]. University of Pennsylvania; 2017. Available from: https://repository.upenn.edu/edissertations/2543

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations